Ọgwụ Zanocin: ntuziaka maka ojiji > Ọgwụgwọ na mgbochi

Zanocin dị n'ụdị usoro ị na-a followingụ:

Ngwọta maka infusion (100 ml na karama, karama 1 n'ime igbe kaadiboodu),
Mbadamba ụrọ, ihe mkpuchi ma ọ bụ ihe nkiri (pcs 10. Na blister, 1 ọnya na paịlị).

Ngwakọta nke 1 mbadamba 1 na 100 ml nke infusion solution gụnyere ihe dị n’ọrụ: ofloxacin - 200 mg.

Mlọ ọgwụ

Ofloxacin, ihe na-arụ ọrụ nke ọgwụ ahụ, bụ ọgwụ buru ibu nke na - ahụ maka otu akụkụ fluoroquinolone. Ọ na-arụ ọrụ na nje nje enzyme DNA, nke bụ maka ịkapụta, na, n'ihi ya, na-agbanwe nkwụsi ike nke DNA nke microorganisms (ibibi ụdọ DNA na-akpata ọnwụ ha). Nri ahụ nwekwara mmetụta nje.

Ofloxacin na-eguzogide ọgwụ dị ka microorganisms ndị a:

Anaerobes: Clostridium na-esi ísì ụtọ
Gram-negative aerobes: Serratia marcescens, Acinetobacter calcoaceticus, Pseudomonas aeruginosa (ngwa ngwa bụrụ nke na-eguzogide), Bordetella pertussis, Providencia stuartii, Providencia rettgeri, Citrobacter koseri, Citrobacter freundii, Proteus vulgareroeroerobibibieroero Klebsiella pneumoniae, Klebsiella oxytoca, Haemophilus influenzae, Haemophilus ducreyi, Morganella morganii, Moraxella catarrhalis,
aerobes gram-nke oma: Streptococcus pyogenes, prọdia ume nke Phoptococcus (ụbụrụ penicillin), staphylococcus saprophyticus, staphylococcus epidermidis (methicillin-sensins strains), staphylococcus aureus (mensicillin-sensinsinsins),
ndị ọzọ: Ureaplasma urealyticum, Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, Legionella pneumophila, Gardnerella vaginalis.

N'ọtụtụ oge, a na-egosipụta nguzogide nke andloxacin site na Treponema pallidum, Nocardia asteroides, ọtụtụ nsogbu nke Streptococcus spp., Enterococcus spp., Nje nje Anaerobic (gụnyere Clostridium difficile, Bacteroides spp., Fusobacterium spp., Peptococcus spppppp. .

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, a na-etinye ofloxacin ngwa ngwa na ọ fọrọ nke nta ka ọ bụrụ ihe niile (ihe dị ka 95%). Bioavailability karịrị 96%, ogo nke jikọtara na protein plasma bụ 25%. Mgbe etinyere, a na-enweta ntinye uche kachasị nke ihe ahụ mgbe awa 1-2 gachara ma mgbe nchịkwa na usoro nke 200 mg, 400 mg na 600 mg bụ nha 2.5 μg / ml, 5 μg / ml na 6.9 μg / ml, otu.

Iri nri nwere ike belata mmata nke ihe a na-aru aru nke Zanocin, mana o nwechaghi emetuta bioavailability ya.

Mgbe otu mkpụrụ ọgwụ intravenous nke 200 mg ofloxacin, nke ga-ewe nkeji 60, ogo plasma kachasị nke ihe ahụ bụ 2.7 μg / ml. Mgbe awa iri na abụọ gasịchara nchịkwa, uru ya gbadara na 0.3 μg / ml. A na-enweta nkwekorita nke ziri ezi naanị mgbe iwebata opekata mpe 4 nke Zanocin. A na-enweta nkezi nke opekempe na ọnụ ọgụgụ kachasị elu mgbe nchịkwa akwara nke ofloxacin kwa awa 12 maka ụbọchị 7 wee bụrụ 0,5 na 2.9 /g / ml.

Ogo o doro anya na nkesa ruru 100 lita. Ofloxacin na - ekesasịkwa akụkụ ahụ na akwara nke anụ ahụ, na - abanye na nzuzo nke prostate gland, sel (alveolar macrophages, leukocytes), bile, osisa, mmamịrị, anụ ahụ, sistemụ iku ume, ọkpụkpụ, anụ ahụ dị nro, akụkụ ahụ na afọ. Ihe ahụ na - emeri ụbụrụ ọbara na ihe mgbochi placental, a na - apịpụ ya mmiri ara ara ma ekpebie ya na mmiri ara (14-60% nke nchịkwa).

Ofloxacin metabolism a na-eme na imeju (ihe ruru 5% nke ọgwụ na-enyocha biotransformation), ihe bụkwa metabolites bụ demethylofloxacin na ofloxacin-N-oxide. Iwepu ọkara ndụ dị iche na awa 4,5 ruo awa 7 na-adabereghị n ’ụzọ ọ bụla. Akpụkpọọala ahụ dị na mmamịrị ahụ - ihe ruru 75-90% agbanweghị, ihe dị ka 4% ofloxacin ka ọpụrụ na bile. Mkpochapụ extrarenal anaghị agafe 20%. Mgbe ịgba ọgwụ otu ọgwụ gbadara 200 mg, a na-ekpebi ofloxacin na mmamịrị ahụ ruo awa iri abụọ na abụọ.

N'ime ndị ọrịa nwere ọrịa ịba ọcha n'anya ma ọ bụ akụrụ, ọnụego nke mkpochasị nke ofloxacin nwere ike kwụsịlata. Nchikota nke ihe di n’ime ahu adighi. N'oge usoro akwara ụkwụ, ihe ruru 10-30% nke ihe na-arụ ọrụ bụ Zanocin.

Ihe ngosi maka ojiji

Ọrịa: urinary tract, gynecological (gụnyere gonorrhea, chlamydia), akụkụ akụkụ ENT, akụkụ iku ume, akụkụ nke ọhụụ, anụ ahụ dị nro na anụ ahụ, eriri afọ,
Endocarditis
Tubkwara nta (dị ka akụkụ nke ọgwụgwọ njikọta dị ka ọgwụ nke abụọ),
Bacteremia.

Ntụziaka maka iji Zanocin: usoro na usoro onunu ogwu

A họrọ nke Zanocin n’otu n’otu.

A na-ewere ọnụ na ọgwụ dị n'ụdị mbadamba. Ngosiputa nke ihe omuma a sitere na ihe ngosi ndi a:

Ọrịa intanetinal na ọrịa urinary na-enweghị nsogbu: ugboro 2 n'ụbọchị, 200 mg nke ọ bụla,
Ọrịa etiologies dị iche iche: ugboro abụọ kwa ụbọchị, 200-400 mg,
Chlamydia: ugboro 2 kwa ụbọchị, 300-400 mg maka ụbọchị 7-10,
Prostatitis kpatara E. coli: ugboro abụọ n ’ụbọchị, 300 mg nke ọ bụla (izu isii).
Ọkpụkpụ na-agbakọghị agbakwụnye: ugboro 400 mg.

A na-eji Zanocin n'ụdị ihe ngwọta maka infusion mee intravenously, ntapu, infusion. A na-enyekarị ọgwụ ọgwụ a:

Ọrịa ọnya na-efe efe: ugboro 2 kwa ụbọchị, 200 mg nke ọ bụla,
Ọrịa intraabdominal, ọrịa nke anụ ahụ dị nro, anụ ahụ, akụkụ okuku ume: 2 ugboro n'ụbọchị, 200-400 mg.

Nsonaazụ

N'oge usoro ọgwụgwọ, mmetụta ndị ọzọ na-esote nwere ike ịmalite:

Sistemụ akwara Central: adịghị ike, anya isi, nchekasị ihi ụra, isi ọwụwa, photophobia,
Usoro nri: enweghi afọ iri, afọ mgbu, afọ ọsịsa, vomiting, anorexia,
Mmeghachi omume nfụkasị: ahụ ọkụ, ahụ ọkụ, ọzịza, itching.

Dodoụbiga ya ókè

Ihe mgbaàmà nke ịdoụbiga ókè nke Zanocin bụ: ịgbatị oge nke oge QT, akpịrị ịkpọ nkụ, ụra, ọgba aghara, iju, ọgba aghara, ọgbụgbọ. N'okwu a, a na-atụ aro lavage gastric na ọgwụgwọ symptomatic. Site na iji ogologo oge gafere oge QT, ịdị na-elele ECG anya mgbe niile.

Mkparịta ụka ọgwụ ọjọọ

Nsonaazụ ojiji nke Zanocin belata antacids (inhibit absorption).

N'ọnọdụ ụfọdụ, Zanocin nwere ike iwelie ọkwa theophylline na plasma.

Analogues nke Zanocin bụ: Dancil, Zoflox, Tarivid, Ofloxacin, Ofloxacin Zentiva, Ofloxacin-Teva, Ofloxacin Protekh, Ofloxin, Uniflox, Phloxal.

Nyocha banyere Zanocin

Dabere na nyocha, a na-enyekarị ndị ọrịa Zanocin ọgwụ dịka akụkụ nke ọgwụgwọ ọrịa metroendometritis, perimetritis na salpingoophoritis, yana ọrịa urological na ọrịa gynecological ndị ọzọ. Dị ka ndị ọkachamara si kwuo, ọgwụgwọ a bịara dị oke mma ma nwee ezi uche, ebe ọ bụ na ofloxacin na-eme nke ọma na ndị na - akpata ọrịa ndị a. Imirikiti ndị ọrịa nabatara ọgwụgwọ nke ọma, naanị obere akụkụ n'ime ha nwere mmeghachi omume ọjọọ n'ụdị afọ ọsịsa, ọgbụgbọ na anorexia, yana ngosipụta nke njigide oge mgbe a na-agwọ Zanocin n'oge oge oyi.

Ofloxacin na-ezobe site na akụrụ, nke na-enye gị ohere ịgwọ usoro mkpali na-eso ọrịa ọrịa uro n'ụzọ gara nke ọma. Thebọchị nke ise site na mmalite nke ọgwụgwọ, nje bacteria na-apụ n'anya na ọdịmma nke ndị ọrịa niile na-adị mma. Nsonaazụ ndị dị ụkọ adịkarịghị ala

A nwekwara ike iji Zanocin gwọọ ọrịa na-akpata mkpali nke Escherichia coli na pseudomonas kpatara. Ọzọkwa, ọ nwere mmetụta immunomodulating. Ya mere, ndị dọkịta na-edepụtakarị ya maka ịgwọ ọrịa AIDS na cancer, ebe ọ bụ na e ji ọnọdụ dị otú ahụ mara mbelata ikike.

Ngwá ọgwụ ọgwụ nke Zanocin

Mlọ ọgwụ Ofloxacin ((±) -9-fluoro-2,3-dihydro-3-methyl-10- (4-methyl-1-piperazinyl) -7-oxo-7H-pyrido1,2,3-de-1,4- benzoxazine-6-carboxylic acid) bụ onye na - akwado ọgwụ mgbochi nke fluoroquinolone otu. Mmetụta nje na-egbu egbu nke ofloxacin, dị ka quinolones ndị ọzọ fluorinated, bụ n'ihi ikike ya igbochi nje enzyme DNA nje.
Ọgwụ nje nke ọgwụ ọjọọ na-ekpuchi microorganisms na-eguzogide penisiliniins, aminoglycosides, cephalosporins, yana microorganisms nwere ọtụtụ nguzogide.
Zanocin OD - ọgwụ na-ewepụta ogologo oge nke ihe arụ ọrụ - ofloxacin. A na-a drugụ ọgwụ ahụ oge 1 kwa ụbọchị. 1 mbadamba Zanocin OD 400 ma ọ bụ 800 mg, nke a na-ewere otu ugboro kwa ụbọchị, na-enye nsonaazụ ọgwụgwọ nke ya na ị tabletsụ mbadamba ọgwụ abụọ nke ofloxacin 200 na 400, n'otu n'otu, na-ewere ya ugboro 2 n'ụbọchị.
Zanocin n'ụdị mbadamba ọrụ na-arụ ọrụ megide ọtụtụ nje bacteria.
Aerobic gram-na-adịghị mma nje: E. coli, Klebsiella spp., Salmonella spp., Proteus spp., Shigella spp., Yersinia spp., Enterobacter spp., Morganella morganii, Providencia spp., Vibrio spp., Citrobacter spp., Serratia spp., Campylobacter spp. , Pseudomonas aeruginosa, P. cepacia, Neisseria gonorrhoeae, N. meningitidis, Haemophilus influenzae, H. ducreyi, Acinetobacter spp., Moraxella catarrhalis, Gardnerella vaginalis, Pasteurella multocida, Helicobacter pyl. Thedọ nwere mmetụta dị iche iche maka ọgwụ. Brucella melitensis.
Aerobic gram-positive bacteria: staphylococci, gụnyere penisiliniin na-emepụta nsogbu, na ụdị methicillin na-eguzogide ọgwụ, streptococci (ọkachasị Ahụ ike na-efe efe), Listeria monocytogenes, Corynebacterium spp.
Ofloxacin na-arụ ọrụ karịa ciprofloxacin na mmekọrita ya Chlamydia trachomatis. Nwekwara ike megide Mycobacterium leprae na Mycobacterium ụkwara nta na ụfọdụ ụdị ndị ọzọ Mycobacterium. Enwere akụkọ banyere mmekọrịta nke ofloxacin na rifabutin n'ihe metụtara M. leprae.
Treponema pallidum, nje, fungi na protozoa abaghị uru nke ofloxacin.
Mlọ ọgwụ Ogwu enenwaan̄ ya onanan̄a me lek kan̄. Ezigbo bioavailability nke ofloxacin bụ 96% mgbe nchịkwa ọnụ. Concentta ụta na plasma ọbara dị 3-4 awa 1-2 mlg / ml 1-2 awa mgbe nchịkwa dị iruru ọgwụ 400 mg. Iri nri anaghị ibelata mmịpụta nke ofloxacin, mana ọ nwere ike belata nwayọ nwayọ maka mmịpụta. Nkeji ọkara ndụ nke ọgwụ ahụ bụ awa 5.8 N'ihi akọnyụ nke akụrụ na-ewepụtakarị akụrụngwa ya, ọgwụ ya na-agbanwe nke ukwuu na ndị ọrịa nwere ọrụ mkpo ya na-arụ ọrụ (mwepụ nke ≤50 ml / min) n'ihi ya, ha chọrọ ndozi nke dose.
Ọrịa metụtara akụrụngwa na-ebelata ịta nke ofloxacin na plasma ọbara. Ofloxacin na-ekesasịkarị na akwara na ahụ mmadụ, gụnyere CSF, olu nke nkesa sitere na 1 ruo 2.5 l / n'arọ. Ihe dị ka 25% nke ọgwụ ahụ na-egbochi protein ndị dị na plasma. Ofloxacin na-agafe Plasenta ma banye na mmiri ara. Ọ ruru n'ọtụtụ akwara na akụkụ ahụ, gụnyere ascites, bile, mmiri, ọgbụgbọ, ọnya afọ, akpa ume, prostate gland, anụ ahụ.
Ofloxacin nwere mgbanaka pyridobenzoxazine, nke na -ebelata metabolic ọnụego nke nne na nna. Ọgwụ kachasị na mmamịrị agbanweghi, yana 65-80% n'ime awa 24 ruo 48. Ihe na-erughị 5% nke dose ahụ na-adị na mmamịrị n'ụdị dimethyl ma ọ bụ N-oxide metabolites. 4-8% nke ọgwụ a isụrụ emeghewo na feces. Obere ego nke ofloxacin na-adị na bile.
Enweghị ọdịiche na oke nkesa ọgwụ yana ndị agadi, ọgwụ ahụ na-apụtakarị site na akụrụ n'ụdị agbanweghị agbanwe, n'agbanyeghị na ọ dị ntakịrị. Ebe ọ bụ na ofloxacin na-ezokarị site akụrụ, yana na ndị ọrịa nwere ọrịa, ana-ahụkarị ọrụ akụrụ gbasara, a na-ahụkarị dose nke ọgwụ maka ọrụ ezumike ezumike, ka akwadoro maka ndị ọrịa niile.
Pharmacokinetics nke Zanocin OD na-enye aka na sistemụ arụmọrụ ya. Nri anaghị emetụta ogo nnabata nke ọgwụ. Mbadamba ọgwụ ọgwụ ofloxacin dị ogologo oge na-agbakarị ọsọ ọsọ ma nwekwa ọkwa dị elu karịa ka e jiri ya na mbadamba ọgwụ ofloxacin ndị a na-ewere ugboro abụọ kwa ụbọchị. Mgbe nchịkwa ọnụ nke Zanocin OD 400 mg, ịba ụba nke ofloxacin na plasma ọbara ruru ka awa 6.778 ± 3.154 wee bụrụ 1.9088 μg / ml ± 0.46588 μg / ml. AUC0-1 bụ 21.9907 ± 4.60537 μg • g / ml. Mgbe nchịkwa ọnụ nke Zanocin OD na ọnụọgụ 800 mg, ọgwụ ịba ụba na ọgwụ na plasma ruru ka ọ bụrụ 7.792 ± 3.0357 h ma ọ bụ 5.22 ± 1.24 μg / ml. Ogo nke AUC0-t bụ 55.64 ± 11.72 μg • g / ml. Na vitro ọgwụ ahụ na - ejikọ protein protein n'ime plasma ihe dị ka 32%.
Egota ịha nhatanha nke ogwu na plasma obara ka emere ihe ochichi nke okpukpu anọ, ma AUC di ihe dika 40% karie na otu mgbe emere ya.
Nwepu nke ofloxacin site n’ahu aru aru. Site na nchịkwa ọnụ a na-eme ugboro ugboro, ọkara ndụ nke ọgwụ ahụ bụ ihe dị ka awa 4-5 na awa 20-25. Ihe ngosipụta nke mkpochapu na olu nkesa zuru oke yiri otu.

Ojiji ọgwụ Zanocin

Zanocin: ọ̀gwụ ahụ dabere n'ụdị microorganism yana ogo nke ọrịa ahụ, afọ, oke ahụ na ọrụ akụrụ nke onye ọrịa. N'ọtụtụ oge, usoro ọgwụgwọ ahụ bụ ụbọchị 7-10, ekwesịrị ịga n'ihu maka ụbọchị 2-3 ọzọ mgbe ekpochapụrụ ihe mgbaàmà nke ọrịa. N'ime ọrịa dị egwu na mgbagwoju anya, enwere ike ịgbatị ọgwụgwọ. Ọgwụ nke ọgwụ ahụ bụ 200-400 mg / ụbọchị na usoro abụọ kewara. Enwere ike ị doseụ ọgwụ nke 400 mg (mbadamba abụọ) n'otu oge, ọkacha mma n'ụtụtụ. Enwere ike ịkwado otu ọgwụ nke 400 mg maka nnukwu ọrịa akụrụngwa na-enweghị nsogbu. Mpempe ọgwụ nke 400 mg na-atụ aro maka ọgwụgwọ nke ekpenta.
A na-a driụ mmiri mgbochi intravenous na dose nke 200 mg (100 ml) na ọnụego nke 400 mg / h na 200-400 mg 2 ugboro n'ụbọchị.
Bụrụ na nke arụ ọrụ ezumike ọrụ ọnụnọ ọgwụ ahụ ehiwere na-eburu n'uche ogo ịdị njọ akụrụ na idozi ya. Usoro akwadoro ọgwụ mbụ akwadoro ma ọ bụrụ na ọ nwere nsogbu akụrụngwa ezughi oke bụ 200 mg, mgbe ahụ, a na-agbazi dose ahụ na-eburu na mwepụ nke creatinine: na ngosipụta nke 50-20 ml / min - na ụdị ọ bụla kwa awa 24, na-erughị 20 ml / min - 100 mg (1/2 t) nwee ike) kwa awa 24
A naghị atụ aro ka ọ gaa n’ihu ị treatmentụ ọgwụ a ihe karịrị ọnwa 2.
Zanocin OD were 1 otu oge n’ụbọchị n’otu oge dịka iri nri. Edebere usoro ubochi niile dịka tebụl (lee n'okpuru). Ndụmọdụ ndị a metụtara ndị ọrịa nwere ọrụ ezumike nkịtị (mwepụ nke creatinine 50 ml / min). All mbadamba nkume ndị ahụ.

Kwa ụbọchị mg

Anwụ nke bronchitis na-adịghị ala ala

Ọrịa na-adịghị efe efe nke anụahụ na anụ ahụ dị n'okpuru ala

Ọrịa urethral na-agbagọ agbagha na akwara

Ọrịa cervicitis na-abụghị nke neococcal nke C. trachomatis kpatara

Ngwakọta dị iche iche nke urethra na cervix kpatara Chlamidia trachomatis na / ma ọ bụ Neisseria gonorrhoeae

Nnukwu ọrịa nke akụkụ ahụ nke akụkụ pelvic

Ọrịa cystitis na-agbadighi Escherichia coli ma obu Klebsiella ka oyi baa

Ọrịa nje na-enweghị nsogbu nke nje ndị ọzọ kpatara

1A na - eme ka ọnụnọ nke ọrịa na - ebute ọrịa.

Bụrụ na nke arụ ọrụ ezumike ọrụ a na-agbazi ọgwụ a na-eme mgbe mgbochi nke creatinine bụ ml50 ml / min. Mgbe usoro izizi a na-adịkarị, mgbe ị na-etinye Zanocin OD 400 mg, a na-agbazi dose ahụ dịka ndị a:

Usoro mmezi na ugboro ole nchịkwa

Maka ọrịa na-efe efe nke anụ ahụ na anụ ahụ dị nro, oyi baa ma ọ bụ na-akpata nrịanrịa, ọrịa na-efe efe nke akụkụ ahụ, a na-atụ aro ị takeụ Zanocin OD 400 mg kwa awa 24. Ruo ugbu a, enweghị data a pụrụ ịdabere na ya banyere mgbanwe na usoro onunu ogwu a tụrụ aro ya.

Ka ọ dị ugbu a, data ezughi oke maka mgbanwe na usoro onunu ogwu akwadoro maka ndị ọrịa nwere nhichapụ ≤20 ml / min.

Mgbe ị na-etinye Zanocin OD 800 mg ruo taa, enwere data ezughi oke gbasara mgbanwe na usoro onyonyo akwadoro maka ndị ọrịa nwere ikike creat50 ml / min. Y’oburu na itinye uche nke creatinine n’ime plasma obara mara, enwere ike kpebie idozi okike nke creatinine:

72 (plasma creatinine (mg / dl))

maka ụmụ nwanyị: nwechapụ creatinine (ml / min) = 0.85 ụmụ nwoke mepụtara.

A na-eleba anya n'ihe gbasara creatinine na plasma ọbara iji chọpụta ọnọdụ ọrụ akụrụ.
Ọrụ imeju na - arụ ọrụ.
Ofloxacin excretion nwere ike belata na oke ịba ọcha n'anya (cirrhosis na / na-enweghị ascites), yabụ, oke dose nke ofloxacin ekwesịghị gafere - 400 mg kwa ụbọchị.
Na ndị ọrịa agadi ọ dịghị mkpa ịhazigharị ọnụọgụ, belụsọ mgbe enwere nsogbu gbasara akụrụngwa ma ọ bụ ọrụ hepatic.

Isiokwu ndị ọkachamara banyere ahụ ike

Otu ọgwụ nje na-ebu ọtụtụ ihe - Zanocin - nke ụlọ ọrụ Indian Corporation Ranbaxi Laboratories Ltd mepụtara. Ihe mejupụtara ọgwụ nke ofloxacin (ofloxacinum) na-emetụta nnọọ ihe dị na DNA nke sel nke microorganisms, na-egbochi ikike ịmụpụta onwe ha.

Ofufe Ọrịa Okwu a batara na ndụ anyị nke na ọ kwụsịrị ịkpa anyị. Ọtụtụ mmadụ na-eche, “Enwere m ọrịa, aụọ ọgwụ ọ ,ụ ,ụ, ihe niile wee pụọ.” Nke a bụ ihe dị oke njọ. Pathogenic microflora nwere ike ibibi ahụ anyị site na n'ime, ọ bụla ruo ọnwụ. Nke a nwekwara ike ime ma ọ bụrụ na ewereghị usoro n'oge. Otu ìgwè nke ndị dọkịta na ndị na-ahụ maka ọgwụ mepụtara Zanocin dị irè iji gbochie mkpụrụ ndụ DNA nke mkpụrụ ndụ pathogenic, na-ebibi ya. Site n'iwepụta onye ọrịa ihe kpatara mmeri ya.Ọgwụ Zanocin ga-eme ka o kwe omume ichefu maka ụdị agbataobi a na-adịghị mma na nke dị ize ndụ dịka ọrịa na-efe efe nke usoro ọmụmụ dị iche iche.

Emee ọgwụ nke Zanocin

Ọgwụ dị egwu nke na-alụ ọgụ megide ụmụ nje dị iche iche na ahụ mmadụ. Ọ nwere mmetụta ọfụma na nje biozyma DNA, nke na-eme ka nkwụsi ike nke DNA nje na-akpata. Na mgbakwunye, ntuziaka maka Zanocin na-egosi na ọgwụ a na-ebute nsonaazụ nje. Na-arụ ọrụ megide microorganisms nke na-emepụta beta-lactamases, yana megide mycobacteria na-ekpo ọkụ ngwa ngwa.

Sing na-agbaso usoro Zanocin na usoro onunu ogwu

Edebere nchịkwa n’ime ọbara nke Zanocin ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa urinary tract (100 mg), akụrụ na ọnya (100-200 mg), akụkụ akụkụ ENT na akụkụ iku ume, ọkpụkpụ na nkwonkwo, ọrịa nke anụ ahụ, akwara afọ, anụ ahụ dị nro. Na mgbakwunye, dị ka nyocha si kwuo, Zanocin na-enyere aka nke ọma na nje bacteria na ọnya ọrịa septik (200 mg). A na-a drugụ ọgwụ ahụ ugboro abụọ n'ụbọchị. Enwere ike ịbawanye elu ma ọ bụ wedata ya site na ogo ọrịa ahụ, ọrụ nke imeju na akụrụ, yana mmetụta akụkụ nke ọgwụ ahụ.

Ọ bụrụ na onye ọrịa nwere ihe ngosi doro anya nke mbelata ihe mgbochi, maka ebumnuche prophylactic, a na-enye ya ọgwụ 400-600 mg maka awa 24.

Mgbe ụfọdụ, a na-eji Zanocin na-atụda ya na 200 mg (ihe kwesịrị ịdị ọhụrụ). Ogologo oge nke usoro a bụ nkeji 30.

Ntụziaka maka Zanocin na-egosi na edekwara ọgwụ a ọnụ. Maka ndị okenye, ọgwụ kachasị kwa ụbọchị bụ 800 mg. Ogologo oge ọgwụgwọ bụ izu 1-1.5.

Ndị ọrịa nwere akụrụ na-adịghị mma kwesịrị ịnwale nyocha ọzọ ma nweta ndụmọdụ ọkachamara. Ọtụtụ mgbe, ndị ọrịa dị otú a ka a na-edenye ọkara otu ụbọchị (100 mg). N'ụfọdụ oge, a na-enye ọgwụ mg 200 maka oge izizi, mgbe nke ahụ gasịrị, a na-eji ọgwụ were ọgwụ nke 100 mg gaa n’ihu.

N'ihe banyere ọrịa imeju, usoro ubochi bụ 100 mg (uru kachasị na nke a ekwesịghị ịfe 400 mg).

A naghị ata ata Zanocin OD 400, were obere mmiri downụọ ya tupu nri ma ọ bụ tupu nri. Usoro ọgwụgwọ niile na-adabere na ọnọdụ onye ọrịa yana oge ọrịa ahụ.

Ihe ngbanwe

Edeghị Zanocin maka ndị ọrịa nwere mmetụta na-emetụta akụkụ nke ọgwụ ahụ, yana ọkwụkwụ, mgbe ọ nwesịrị isi, yana usoro mkpali nke usoro akwara na-emetụta ụbụrụ. Amachibidoro ya iwu iji ọgwụ eme ihe maka ụmụaka na-erubeghị afọ 18, ụmụ nwanyị dị ime, yana n'oge a na-enye nwa ara.

Achọrọ ndị ọzọ nyocha maka ndị ọrịa na-arịa ụbụrụ arteriosclerosis, ọnya ụjọ akwara na ọnya ụbụrụ.

Usoro onunu ogwu na nhazi

N'ime ụdị edozi, a na-edozi Zanocin n'ọbara. Usoro onunu ogwu na usoro nke okpukpo a dabere na udiri oria a na ebe oria di, oria a di oria, oria onye oria, oru ya na akuru ya na nnabata nke umu ihe.

A na-enyekarị ndị okenye okenye 200 mg otu ugboro ma ọ bụ ugboro abụọ n'ụbọchị. N'ime ọrịa siri ike ma ọ bụ gbagwojuru anya, enwere ike ịbawanye ọgwụ ruo 400 mg ugboro abụọ n'ụbọchị. Ihe kacha anabata ị ga-anabata kwa ụbọchị bụ 800 mg. Ogologo oge nke infusion bụ nkeji 30-60. Tupu nchịkwa, a na-eji ọgwụ dextrose 5% dil Zanocin. Ozugbo ọnọdụ onye ọrịa ahụ dị mma, a na-ebugharị ya na nchịkwa ọnụ nke ọgwụ n'ụdị mbadamba ihe.

N'ime, a na-ewere Zanocin 200-400 mg kwa ụbọchị. Ọ bụrụ na usoro ị ga-eme kwa ụbọchị karịrị 400 mg, a na-atụ aro ka ị were ya oge, ọkacha mma n'ụtụtụ. A na-ekewa usoro ọgwụgwọ dị elu ka usoro abụọ. Ọ dị mkpa iji ọgwụ tupu nri ma ọ bụ n'oge nri.

Site na gonorrhoea, dịka iwu, otu ọgwụ 400 mg ofloxacin zuru ezu. Site na prostatitis, a na-enyekarị 300 mg ọgwụ kwa ụbọchị.

Ọ bụrụ na arụ ọrụ ezughi oke ọrụ, a na-ebelata dose nke Zanocin:

Ọ bụrụ na KK bụ 50-20 ml / min - 100-200 mg kwa ụbọchị,
Ọ bụrụ na CC dị n'okpuru 20 ml / nkeji - 100 mg / ụbọchị.

A na-enye ndị ọrịa ịba amị amị ihe 100 mg otu ugboro n’ụbọchị.

Site na nkwarụ imeju na imeju, usoro ubochi ekwesịghị ịkarị 400 mg.

Ogologo oge ọgwụgwọ Zanocin na-adabere na uche nke pathogen ka ofloxacin na foto izugbe. Dịka iwu, usoro ọgwụgwọ dịruru:

Ọrịa nke anụ ahụ na sistem - ụbọchị iri,
Site na ọrịa na-efe efe nke akụkụ ahụ pelvic - 10-14 ụbọchị,
Na ọrịa urinary tract - 3-10 ụbọchị,
Na prostatitis - ruo izu isii.

Mgbe asachapụla ihe mgbaàmà niile nke ọrịa ahụ, ị takingụ ọgwụ ahụ ka akwadoro ka ọ dịkarịa ala ụbọchị abụọ ọzọ.

A na-enyekarị Zanocin OD mbadamba ọrụ ogologo oge:

Site na oria urinary na oria nke oria a na-ebute oria - 400 mg / ubochi rue ubochi 3-7, ya na oria di otutu
Na prostatitis - 400 mg kwa ụbọchị maka izu isii,
Maka ọrịa nke anụ ahụ na anụ ahụ dị nro, ọrịa akụkụ iku ume - 800 mg / ụbọchị. n'ihi na 10 ụbọchị.

Ntụziaka pụrụ iche

Oge ọgwụgwọ niile dị mkpa:

Gbalịsie ike na ịrationụ ahụ nke ọma,
Na-enyocha glucose ọbara gị kwa oge
Zere ikpughe UV,
Jiri nlezianya na-anya mgbe ị na-anya ụgbọ ala na-arụ ọrụ nwere ike ịdị njọ nke chọrọ oke mmeghachi omume dị elu.

Ọ bụrụ na ịchọrọ iji Zanocin ogologo oge, ịkwesịrị ịchịkwa foto nke ọbara mgbatị, akụrụ na ọrụ imeju.

A na-ahụta mbelata nke ofloxacin site na ojiji nke oge:

antacids nwere magnesium, calcium na / ma ọ bụ aluminom,
ihe na-agbanwe
nkwadebe nwere ilu di iche iche,
multivitamins, nke gụnyere zinc.

Maka nke a, ọ dịkarịa ala, elele anya ka elekere awa abụọ n'etiti usoro ọgwụ ndị a.

NSAIDs tinyere oflaxacin na-abawanye ohere nke ịkwalite mmetụta na-akpali akpali na sistemụ akwara na mmepe nke ihe ọdịdọ.

Egosiputara nkwalite mmekọrịta n'etiti mmadu na ijikọ ọnụ nke Zanocin yana aminoglycosides, ọgwụ mgbochi beta-lactam na metronidazole.

Ofloxacin na-agbatị ikuku uche, ihe na-eduga n'ịba ụba na ntinye ya na mmepe nke mmetụta mmetụta ndị ọzọ.

Ashof, Zoflox, Geoflox, Oflo, Oflox, Ofloxacin, Ofloxabol, Oflomak, Oflotid, Ofloxin, Tarivid, Taritsin, Tariferid.

Nsonaazụ nke ọgwụ Zanocin

N’ihi nsonaazụ ọmụmụ banyere iji ọgwụ ofloxacin ugboro ugboro, a na-ahụkarị ihe ndị a: ọgbụgba (3%), isi ọwụwa (1%), afọ ọsịsa (1%), vomiting (1%), ihe nfụkasị (1%), itching akpụkpọ ahụ (1%), itching nke akụkụ mpụga anụ ahụ n’ime ụmụ nwanyị (1%), vaginitis (1%), dysgeusia (1%).
N ’ule ụlọ ọgwụ, ihe ndị ọ na-esokarị na-akpata ọ bụla n’agbanyeghi oge ọgwụ a bụ ọgbụgba (10%), isi ọwụwa (9%), dysomnia (7%), itching nke akụkụ ahụ dị na mpụga ụmụ nwanyị (6%), dizziness (5 %), vaginitis (5%), afọ ọsịsa (4%), vomiting (4%).
N'ime ule ụlọ ọgwụ, mmetụta ndị kachasị emetụta ya mere n'agbanyeghị oge oge ọgwụ ahụ ma bụrụ nke a hụrụ na 1-3% nke ndị ọrịa bụ afọ mgbu na colic, mgbu obi, agụụ nri, egbugbere ọnụ akọrọ, dysgeusia, ike ọgwụgwụ, flatulence, nsogbu nke Ọkpụkpụ akwara afọ, obi ọgbụgba, pharyngitis, pruritus, ahụ ọkụ, ihe ọkụ ọkụ, ọnyụnyụ, ụra, ahụ mgbu, mpụga ahụ nke nwanyị, nhụjuanya anya, afọ ntachi.
Nsonaazụ ndị edepụtara na ọmụmụ nyocha ahụike na erughi 1% nke ọnọdụ, n'agbanyeghị oge ọgwụ a:
izugbe nsogbu: asthenia, itu ura, oria, mgbu n’ukwu, imi,
site na obi: obi njide, edema, ọbara mgbali elu, hypotension arterial, sensation of heartbeat pressure, vasodilation,
site na eriri afọ: dyspepsia
sitere na usoro mkpụrụ ndụ: mmetụta nke okpomoku, oke iwe, mgbu na ihe ọkụkụ na akụkụ akụkụ nke ụmụ nwanyị, dysmenorrhea, metrorrhagia,
site na usoro akwara: arthralgia, myalgia,
si sistem n ’etiti: ihe mgbu, nchekasị, enweghi ike ime ihe ọ bụla, ịda mba, nrọ na-adịghị mma, obi ụtọ, ihe ịma mma, nchekasị, ịma mmụọ, vertigo, ịma jijiji,
site n'akụkụ nke metabolism: akpịrị ịkpọ nkụ, ịta ahụhụ,
site na okuku ume: njide iku ume, ụkwara, rhinorrhea,
nfụkasị ahụ na mmeghachi omume anụ ahụ: angioedema, hyperhidrosis, urticaria, ihe onwu, vasculitis,
site na anụ ahụ anụ ahụ: ntị ụfụ, tinnitus, fotophobia,
si urinary system: dysuria, urination ugboro ugboro, njigide urinary.
Achọpụtara mgbanwe na plọg lab na ≥1% nke ndị ọrịa nwere ojiji ofloxacin ugboro ugboro. Mgbanwe ndị a bụ ma ị takingụ ọgwụ na ọrịa na-akpata ya:
site n'ọbara ọbara: anaemia, leukopenia, leukocytosis, neutropenia, neutrophilia, stab neutrophilia, lymphocytopenia, eosinophilia, lymphocytosis, thrombocytopenia, thrombocytosis, ESR mụbara,
site na sistemu nke hepatobiliary: mmụba nke alkaline foseti, asat, alat,
paradaịs nke ụlọ nyocha: hyperglycemia, hypoglycemia, hypercreatininemia, ụba urea, glucosuria, proteinuria, alkalinuria, hypostenuria, hematuria, pyuria.
Ahụmịhe azụmaahịa
Nsonaazụ ndị ọzọ mere na-agbanyeghị oge were iji ọgwụ ahụ ka etinyere nsonaazụ ahịa nyocha nke quinolones, gụnyere ofloxacin.
Si usoro obi: thrombosis nke ụbụrụ, akụkụ akwara akụkụ, tachycardia, hypotension arterial / ujo, nkụda mmụọ, achricular tachycardia dịka pirouette.
Site na usoro endocrine na metabolism: hyper - ma ọ bụ hypoglycemia, karịsịa na ndị ọrịa nwere ọrịa shuga na-eji ọgwụ insulin ma ọ bụ ọgwụ hypoglycemic ọgwụ.
Site na eriri afọ: ịba ọcha n'anya, jaundice (cholestatic ma ọ bụ hepatocellular), ịba ọcha n'anya, akụkụ nke eriri afọ, ọdịda imeju (gụnyere ọrịa na-egbu egbu), ọrịa pseudomembranous colitis (ọrịa nke pseudomembranous colitis nwere ike ime ma n'oge ọgwụgwọ ma ọ bụ ọgwụ nje), na-agba ọbara site na eriri afọ, hiccups, mucous soreness shei nke onu ura, okpukpo obi.
Site na usoro mkpụrụ ndụ: ọria candidiasis.
Site n'ọbara ọbara: anaemia (gụnyere hemolytic na aplastic), ọbara ọgbụgba, pancytopenia, agranulocytosis, leukopenia, mgbochi nke ọrụ ụmị ọkpụkpụ, thrombocytopenia, thrombocytopenic purpura, petechiae, ọbara ọgbụgba / ọnya ọgbụgba.
Site na usoro mọzụlụ: akwara mkpụrụ obi, akwara ike ọgwụgwụ, adịghị ike, akwara ọkpụkpụ akwara ozi.
Site n'akụkụ nke usoro ụjọ ahụ: ụra abalị, echiche igbu onwe ya ma ọ bụ omume, disoriration, psychotic reaction, paranoia, phobia, iwe, nchekasị, oke iwe / iro, nkụchi obi, obi ọgbụgba, neuropathy echiche, ataxia, nhazi nke adịghị mma, mkpocha omume ga - ekwe omume. myasthenia gravis na extrapyramidal ọrịa, dysphasia, dizziness.
Site na usoro iku ume: dyspnea, bronchospasm, pneumonitis nfụkasị, wheezing.
Allergic na mmeghachi omume anụ ahụ: mmeghachi omume anaphylactic / anafilactoid / ujo, purpura, ọrịa serum, multimorphic erythema / Stevens-Johnson syndrome, erythema nodosum, exfoliative dermatitis, hyperpigmentation, toxic epidermal necrolysis, conjunctivitis, photoensitivity / phototoxicity reaction, vesiculobulosis.
Si uche: diplopia, nystagmus, ọhụhụ ọhụhụ, dysgeusia, isi isi, ntị na nguzozi, nke, dịka iwu, gafere mgbe ịkwụsị ọgwụ ahụ.
Site na urinary system: ọrịa anauria, polyuria, akụrụ ke akụrụ, ọdịda akwara, interstitial nephritis, hematuria.
Nnyocha ụlọ nyocha: ịgbatị oge prothrombin, acidosis, hypertriglyceridemia, cholesterol mụbara, potassium, ntụrụ ọrụ ọrụ, gụnyere gamma-glutamyltranspeptidase, LDH, bilirubin, albuminuria, candiduria.
N'ime ule nke ụlọ ọgwụ iji ojiji nke quinolones ugboro ugboro, achọpụtara nkwarụ ophthalmic, gụnyere cataract na pinpoint opacification nke lens. Emebeghị njikọ dị n'etiti ị theụ ọgwụ na nrịanrịa ndị a.
Egosipụta ihe mere kristalia na cylindruria site na iji quinolones ndị ọzọ.

Mkpakọrịta ọgwụ ọgwụ Zanocin

Ihe antacids, sucralfate, igbe igwe, multivitamins. Quinolones na-etolite mmiri ọgwụ na ndị na-enwe alkaline na ndị na-ebu ọla. Ojiji nke quinolones na nkwonkwo antacid nwere calcium, magnesium ma ọ bụ aluminom, sucralfate, divalent ma ọ bụ trivalent cations (iron), nhazi multivitamin nwere zinc, didanosine nwere ike belata nnabata nke quinolones, si otú a belata itinye uche ha na usoro. A na-a drugsụ ọgwụ ndị dị n’elu awa 2 tupu ma ọ bụ mgbe ewere ofloxacin.
Ahịhịa Enweghị mmekọrịta ọ bụla achọpụtara.
Ihe nkiri cyclosporins. Enweghị mkpesa banyere mmụba nke ọkwa cyclosporine na plasma ọbara mgbe ejikọtara ya na quinolones. Emebeghị ka omumu ntughari n'etiti quinolones na cyclosporins guta.
Cimetidine mere mmebi nke mkpochapu ụfọdụ quinolones, ya bụ na o butere mmụba na ọkara ndụ ọgwụ na AUC. Agụbeghị mmekọrịta dị n'etiti ofloxacin na cimetidine.
Ọgwụ nke mejupụtara cytochrome P450 enzymes. Ọtụtụ nhazi quinolone na-egbochi ọrụ enzymatic nke cytochrome P450. Nke a nwere ike iduga ogologo oge nke ọkara ọgwụ nke otu sistemụ mejupụtara (cyclosporine, theophylline / methylxanthines, warfarin) mgbe ejikọtara ya na quinolones.
Ndị NSAID. Ihe NSAIDs na quinolones jikọtara ọnụ, gụnyere ofloxacin, nwere ike ibute ihe egwu nke nsonaazụ na-akpali akwara na usoro akwara ozi.
Probenecid. Ihe probenecid na quinolones jikọtara ọnụ nwere ike ịmetụta mkpịsị akwara gbasara akwara. Amụrụ ihe gbasara probenecid na exclotion nke ofloxacin.
Theophylline. Nkwa Plasma theophylline nwere ike ịbawanye mgbe ejiri ya na ofloxacin. Dị ka quinolones ndị ọzọ, ofloxacin nwere ike ịgbatị ndụ ọkara nke theophylline, mee ka ọkwa plasma nke theophylline dịkwuo elu yana ihe egwu nke mmetụta theophylline. Ọ dị mkpa ikpebi ọkwa nke theophylline na plasma ọbara na-ahazi ma mezie ọnụọgụ ahụ mgbe a na-ejikwa ya na ofloxacin. Nsonaazụ (gụnyere ihe ọdịdọ) nwere ike ịpụta na / enweghị ịrị elu na ọkwa theophylline na plasma ọbara.
Warfarin. Qufọdụ quinolones nwere ike ịkwalite nsonaazụ nchịkwa ọnụ nke warfarin ma ọ bụ nke ya. Ya mere, n'iji jikọtara quinolones na warfarin ma ọ bụ usoro ya, a na-enyocha oge prothrombin yana ndị ọzọ na-egosi coagulation ọbara.
Ndị ọrụ Antidiabetic (insulin, glyburide / glibenclamide). A kọrọ na ọ gbanwere glucose ọbara, gụnyere hyper- na hypoglycemia, mgbe ị na-a drugsụ ọgwụ quinolone na ọgwụ antidiabetic, yabụ ị kwesịrị ị na-enyocha glycemia mgbe niile na ojiji nke ọgwụ ndị dị n'elu.
Ọgwụ ọjọọ na-emetụta ihe ngosi mkpụrụ ndụ akwara tubular excretion (furosemide, methotrexate). Site na nhazi nke quinolones na ọgwụ na-emetụta oge mpụ akwara, enwere ike imebi excretion na ịba ụba nke quinolones na plasma ọbara.
Mmetụta na nnwale ụlọ nyocha ma ọ bụ nyocha. Qufọdụ quinolones, gụnyere ofloxacin, nwere ike ịnye nsonaazụ ụgha maka mkpebi nke opiates na mmamịrị na nchịkwa ọnụ nke ndị na - ahụ maka ọgwụ immunological.
Na enweghị data na ndakọrịta nke azịza ya na ngwakọta infusion ndị ọzọ ma ọ bụ nkwado Zanocin n'ụdị ihe ngwọta maka infusion, a ga-eji ya iche. Ọgwụ a kwekọrọ na isotonic sodium chloride solution, nkwụchi nke Ringer, glucose 5% ma ọ bụ fructose.