Etu esi eji ọgwụ ọgwụ Neyrolipon?

Parenteral, n'ime 300 na 600 mg: mamịrị na polyneuropathy na-arịa ọrịa shuga.

N'ime 12 na 25 mg: imeju na-egbu egbu, cirrhosis, ịba ọcha n'anya, ịba ọcha n'anya A, mmịpụta (gụnyere nnu nke ọla ndị dị arọ), na-egbu egbu na toadstool, hyperlipidemia (gụnyere ya na mmepe nke akwara na atherosclerosis - ọgwụgwọ na mgbochi )

Nsonaazụ

Site na ngwe nri: mgbe ejiri ọnụ mee ya - ọgbụgbọ, ọgbụgbọ, mgbu nke afọ, afọ ọsịsa.

Mmeghachi omume nfụkasị ahụ: ọnya anụ ahụ, itching, urticaria, ujo ọgwụ.

Ndị ọzọ: isi ọwụwa, metabolism glucose (hypoglycemia), na nchịkwa iv ngwa ngwa - igbu oge ma ọ bụ iku ume siri ike, ịba ụba intracranial, nkwarụ, diplopia, ọnya ọbara dị na akpụkpọ ahụ na mucous membranes na ọchịchọ ọbara ọgbụgba (n'ihi ọrụ platelet na-arụ ọrụ nke ukwuu. )

Capsule Neurolipon (Neurolipon)

Ntuziaka maka ọgwụ eji ọgwụ eme ihe

• Ihe ngosi maka ojiji
• Mpempe mwepụta
• Pharmacodynamics nke ọgwụ
• Pharmacokinetics nke ọgwụ
• Jiri n’oge ime
• Ihe ngbanwe
• Nsonaazụ
• Usoro onunu ogwu na nhazi
• Dodoụbiga ya ókè
• Mmekọrịta na ọgwụ ndị ọzọ
• Kpachara anya maka iji ya
• Ọnọdụ nchekwa
• Exbọchị mmebi

Nhazi ọkwa nosological (ICD-10)

Usoro onunu ogwu na nhazi

Na / n'ime. Ndị okenye na dose 600 mg / ụbọchị. Tinye nwayọ - karịa 50 mg / min nke thioctic acid (1.7 ml nke ihe ngwọta maka infusion).

Ekwesịrị iji ọgwụ mee ihe site na infusion na 0.9% sodium chloride solution otu ugboro n'ụbọchị (a na-agwakọta 600 mg nke ọgwụ ahụ na 50-250 ml nke 0.9% sodium chloride solution). N'okwu ndị siri ike, enwere ike inye 1200 mg. Ekwesịrị ka echedo ihe dị n’etiti infusion site n’ite ọkụ site na iji ọta na-ekpuchi ha.

Usoro ọgwụgwọ sitere na izu abụọ ruo izu anọ. Mgbe nke ahụ gasịrị, ha na-atụgharị na ọgwụgwọ mmezi ya na usoro onunu ogwu nke thioctic acid maka nchịkwa ọnụ na 300-600 mg / ụbọchị maka ọnwa 1-3. Iji mee ka mmetụta ọgwụgwọ dịkwuo mma, a na-atụ aro ka a rụọ ọrụ ọgwụgwọ ya na ọgwụ ọgwụ Neyrolipon ugboro abụọ n'afọ.

E guzobeghị ịdị irè na nchekwa nke ọgwụ ahụ na ụmụaka.

Mpempe mwepụta

Na-echebara echiche maka ngwọta maka infusion, 30 mg / ml. Na ampoules iko agba aja aja, na mgbanaka ezumike ma ọ bụ nkwụsịtụ, 10 ma ọ bụ 20 ml.

5 ma ọ bụ 10 nkwu. ya na akpa oyuyo oyuyo imebisi ma obu n’enweghi ya na ngwugwu nke nwere ndi ichie.

5 am. na ọnya ọnya na-ahụ maka ihe nkiri PVC. 1 ma ọ bụ 2 bl. ya na ampoules tinyere akpa nke ihe nkiri ojii PE ma ọ bụ na-enweghị ya na ngwugwu kaadiboodu.

Emeputa

PJSC "Farmak". 04080, Ukraine, Kiev, abụrụ. Frun, 63.

Tel./fax: (8-10-38-044) 417-10-55, 417-60-49.

Nzukọ a na-anabata nkwupụta sitere n'aka ndị na-ere ahịa: ụlọ ọrụ nnọchite anya Farmak JSC ọha na Russia: 121357, Moscow, ul. Kutuzovsky Prospect, 65.

Tẹ.: (495) 440-07-58, (495) 440-34-45.

Ihe ngbanwe

Ọgwụ na ọgwụ ndị mejupụtara ọgwụ ahụ.

Oge ime, oge ị breastụ nwa (ahụghị ọgwụ ahụ ezughi ezu).

Undermụaka na-erubeghị afọ 18 (etinyere ike na nchekwa nke iji).

Mgbakwunye ọzọ maka iji Neurolipon n'ụdị capsules bụ enweghị nkwekọrịta galactose, ụkọ lactase ma ọ bụ malabsorption glucose-galactose.

Mlọ ọgwụ

Arụ ọrụ nke Neyrolipon - thioctic acid - bụ nke a na - ekekọta ozugbo ahụ ahụ ma rụọ ọrụ dịka coenzyme na decarboxylation oxidative decarboxylation nke α-ketonic acid. Ọrụ dị mkpa na-arụ site na thioctic acid na metabolism nke ike nke mkpụrụ ndụ. Na ụdị nke lipoamide, acid na-arụ ọrụ dị ka ihe dị mkpa maka ogige nke ọtụtụ enzyme, nke bụ ihe na-enye aka maka decarboxylation nke α-keto acid nke usoro Krebs.

Neyrolipon nwere ihe antitoxic na antioxidant, na mgbakwunye, thioctic acid nwere ike iweghachi antioxidants ndị ọzọ, dịka ọmụmaatụ, na ọrịa shuga mellitus, na-ebelata insulin iguzogide ma na-ebelata mmepe nke neuropathy mpaghara.

Thioctic acid na-enyere aka belata glucose plasma ma na-akpakọ glycogen na imeju. Ọ na - emetụta metabolism cholesterol, na - ekere òkè na nhazi nke metabolism nke abụba na carbohydrates, na - eme ka ọrụ imeju dị na ya site na hepatoprotective, antioxidant and detoxification ውጤታማ.

Mlọ ọgwụ

Omume Pharmacokinetic dabere na usoro nke ngwa:

• nchịkwa ọnụ: nnabata na-apụta na eriri afọ (eriri afọ) ngwa ngwa na kpamkpam, ebe oriri nke Neurolipon nwere nri, a na-ebelata mmịcha. Bioavailability sitere na 30 ruo 60%, ihe mejupụtara ya bụ metabolized tupu ọ banye na usoro sistemụ mgbe ọ na-agafe mgbidi nke eriri afọ na imeju (nsonaazụ nke mbụ). Oge ị ga-eji nweta ntinye kachasị (T_max) hà 4 μg / ml dị ihe dị ka nkeji iri atọ. Metabolism n'ime imeju na-aputa ihe site na nsị nke ụdọ na conjugation n'akụkụ. A na - ekepụta Thioctic acid na mmamịrị site na akụrụ: n'ụdị metabolites - 80-90%, agbanweghị - obere ego. Ndi_1/2 (ọkara ndụ) bụ minit 25,
• nchịkwa parenteral: bioavailability bụ

30%, metabolism na-aputa n'ime imeju site na iji ihe ndozi nke eriri ala na conjugation. Ndi_1/2 - Nkeji 20-50, mkpochapu zuru ezu

694 ml / min, olu nke nkesa bụ lita 12,7. Mgbe otu mkpụrụ ọgwụ nke thioctic acid gbara ya gburugburu, akụkụ akụrụ ya nke mbụ ruo awa atọ bụ ihe dịka 93-97% n'ụdị ihe ma ọ bụ ihe ndị agbanweghi agbanwe.

Ntụziaka maka iji Neyrolipon: usoro na usoro onunu ogwu

A na -ekwu ya akpukpo isi neuroleipone na afo efu (ọkara awa tupu nri), na -ejighị ntakịrị mmiri ma ọ bụ mmiri mmiri na-anọpụ iche.

Usoro ọgwụgwọ akwadoro: 300-600 mg otu ugboro n'ụbọchị. Maka ọgwụgwọ nke polyneuropathy mamịrị na-arịa ọrịa shuga na mbido, nchịkwa parenteral nke thioctic acid dị mma.

Dọkịta na-ekpebi oge ọ ga-anọ n'ụlọ ọgwụ.

Na-echebara echiche maka ngwọta maka infusion

A na-eji ihe ndozi kwadebere site na Neyrolipon na-etinye ume na ntinye ngwa ngwa (≤ 50 mg thioctic acid kwa nkeji).

Usoro ọgwụgwọ akwadoro: mg mg otu ugboro kwa ụbọchị, n'ọnọdụ ndị siri ike, ka akwadoro ihe ruru 1200 mg.

Iji kwadebe ngwakọta infusion, a na-eji 0.9% NaCl ngwọta mee ihe na 50-250 ml kwa 600 mg nke thioctic acid.

Ogologo oge ọ na - agwọ ọrịa bụ izu izu 2-4, mgbe nke a gasịrị, ha na - agbanye na ọgwụgwọ mmezi na thioctic acid n'ụdị nkwadebe ọnụ (dose nke 300-600 mg kwa ụbọchị) maka ọnwa 1-3.

Iji mee ka mmetụta nke Neyrolipona guzosie ike, a na-atụ aro ka a na-eduzi ọmụmụ ihe ugboro ugboro ugboro abụọ kwa afọ.

Dodoụbiga ya ókè

Mgbaàmà nke ịdoụ mmiri nke thioctic acid mgbe a na -ewere ya ọnụ nwere ike isi ọwụwa, ọgbụgbọ, vomiting, nkwarụ amamịghe, nnukwu nsogbu na acid-base balance with lactic acidosis, hypoglycemic coma, ọbara coagulation siri ike ruo ọnwụ.

Iji lebara ọnọdụ ahụ, ị ​​kwesịrị ịkwụsị ị takingụ ọgwụ ahụ ozugbo, sachaa afọ ahụ, wee nwee unyi na-arụ ọrụ ma rụọ ọrụ mmezi.

Mgbaàmà nke ịptomsụ ọgwụ thioctic acid nke nwere nchịkwa parenteral amaghị.

Ọ bụrụ n ’ị na-enyo n’ ịdoụbiga ihe ókè ma ọ bụ ihe na - emetụta ọghọm ndị ọzọ, ị ga - akwụsịtụ infusion, mgbe ahụ, na - ewepụghị agịga irighiri mmiri, were nwayọ wepụta 0.9% isotonic NaCl ngwọta site na sistemụ. Ọgwụ enweghị ọgwụ mgbochi akọwapụtara; a na-atụ aro ọgwụgwọ symptomatic.

Ntụziaka pụrụ iche

A ga-echedokwa ihe dị n'ime ala nke nwere thioctic acid site n'ìhè site na ikpuchi arịa ndị nwere ọta.

Na ọgwụgwọ ndị ọrịa na-arịa ọrịa shuga, ọ dị mkpa ileba anya n'ọkwa glucose ọbara ugboro ugboro, n'ọnọdụ ụfọdụ, ọ bụrụ na ọ dị mkpa, ịhazigharị ọgwụ nke ndị ọrụ hypoglycemic iji gbochie mmepe nke hypoglycemia.

N'oge ọgwụgwọ Neurolipone, mmadụ kwesịrị izere ị drinkingụ ihe ọ containingụ containingụ nwere mmanya, ebe ọ bụ na ethanol na-egbochi ọrụ ọgwụgwọ ya.

Mkparịta ụka ọgwụ ọjọọ

• glucocorticosteroids: thioctic acid na-eme ka arụ ọrụ mgbochi mkpali ha dịkwuo mma,
• Cisplatin: mbelata na ọgwụgwọ ọgwụgwọ ya,
• ọgwụ nwere ọla (ígwè, magnesium, nhazi nke calcium): thioctic acid na-ejikọ ọla, yabụ, a ga-ezere nchịkwa ha nke imekotaotu onwe ya, ọ dị mkpa iji dozie oge dị n'etiti elekere nke opekata mpe,
• insulin ma ọ bụ onodu hypoglycemic aṣoju: thioctic acid nwere ike mee ka mmetụta ha pụta,
• ethanol na metabolites ya: gbochie ihe thioctic acid.

Ngwakọta ọgwụ nke nitrolipon n'ụdị siri ike sols na -akọrọ mmiri na sugars, ya mere, ọ dakọtara na ngwọta nke Ringer, glucose na fructose. Ọ dakọtara na agbanwe agbanwe nke ogige na-emeghachi na ndị SH-ma ọ bụ mebie àkwà mmiri na nkwadebe nwere ethanol.

Nyocha banyere neuroleepone

Nyocha banyere neuroleepone bụ ihe na-arụ ụka nke ukwuu. Maka ụfọdụ ndị ọrịa, ọgwụ ahụ adabaghị adaba, a na-akpọ ya dị ka ọgwụgwọ na-adịghị ike nke na-ebelata mgbaàmà nke ọrịa ahụ ma na-akpata mmeghachi omume ọjọọ.

N'ọtụtụ nyocha ndị ọzọ, a na-ahụ neurolypone dị ka ọgwụ ịhọrọ n'ihi enweghị mmeghachi omume na arụmọrụ dị elu.

Pricegwọ ọnụ nke Neyrolipon n'ụlọ ọgwụ

Atụmatụ maka atụmatụ maka NeroLipone:

• itinye uche na nkwadebe maka ihe ngwọta maka infusion (ampoules 5 na otu kaadiboodu): na ampoules nke 10 ml - 170 rubles, na ampoules nke 20 ml - 360 rubles,
• capsules (pcs 10 n'ime blisters, 3 blisters na otu kaadiboodu) - 250 rubles.

Mmụta: Universitylọ akwụkwọ Mahadum Medical Ahụike Moscow nke mbụ aha ya bụ I.M. Sechenov, ọpụrụiche "General Medicine".

A na-emejupụta ozi gbasara ọgwụ a, enyere ya aka maka ihe ọmuma ma ọ doghị ntuziaka ndị isi. Medication medicationụ onwe gị ọgwụ dị ize ndụ nye ahụ ike!

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

A na-emezi ihe ngwọta maka infusion ka ndị okenye na 600 mg kwa ụbọchị. A na-achịkwa ya nwayọ nwayọ - ihe kariri 50 mg nke thioctic acid (1.7 ml nke ngwọta maka infusion) kwa nkeji.

Ekwesịrị iji ọgwụ mee ihe site na infusion na 0.9% sodium chloride solution 1 oge kwa ụbọchị (a na-agwakọta 600 mg nke ọgwụ ahụ na 50-250 ml nke 0.9% sodium chloride solution). N'okwu ndị siri ike, enwere ike inye 1200 mg. Ekwesịrị ka echedo ihe dị n’etiti infusion site n’ite ọkụ site na iji ọta na-ekpuchi ha.

Usoro ọgwụgwọ ahụ na-ewe site n'izu abụọ ruo izu anọ. Mgbe nke ahụ gasịrị, ha na-atụgharị na usoro nlekọta mmezi ya na Neyrolipon maka nchịkwa ọnụ (capsules) na ntụtụ 300-600 mg kwa ụbọchị maka ọnwa 1-3. A na -ezupupu Capsules n'ọnụ ma na-ata ata, jiri obere mmiri hichaa ya, nkeji 30 tupu nri (na afọ efu). Iji mee ka mmetụta ọgwụgwọ dịkwuo mma, a na-atụ aro usoro ọgwụgwọ ugboro abụọ n'afọ.

Ọ bụ dọkịta ga-ekpebi oge ọgwụgwọ ọ bụla.

E guzobeghị ịdị irè na nchekwa nke ọgwụ ahụ na ụmụaka.

Omume ọgwụ

A na-agwakọta Thioctic acid, nke bụ akụkụ nke Neuro Lipon n'ime ahụ ma na-eme dị ka coenzyme na oxidative decarboxylation nke alpha-keto acid, ma na-arụ ọrụ dị mkpa na metabolism ike nke sel. Na ụdị amide (lipoamide), ọ bụ ihe dị mkpa maka ọtụtụ enzyme nke na-ejikọ decarboxylation nke Krebs alpha-keto acid. Thioctic acid nwere ọgwụ antitoxic na mmetụta antioxidant, ọ na-enwe ike iweghachi antioxidants ndị ọzọ, dị ka ọrịa shuga. N'ime ndị ọrịa nwere ọrịa shuga, thioctic acid na-ebelata insulin na-egbochi ma gbochie mmepe nke neuropathy mpaghara.

Ọ na - enyere aka belata mkpụkọ glucose na plasma ọbara na mkpokọta nke glycogen na imeju. Acid Thioctic na-emetụta metabolism nke cholesterol, na-ekere òkè na nhazi nke lipid na carbohydrate metabolism, na-eme ka ọrụ imeju dịkwuo mma (n'ihi usoro ịba ọcha n'anya, antioxidant, mmetụta detoxification).

Mmekorita

Na - eme ka ọgwụ mgbochi mkpịsị ọgwụ glucocorticosteroid rụpụta ihe mgbochi.

Site na nchịkwa oge nke thioctic acid na cisplatin, a na-achọpụta mbelata nke arụmọrụ nke cisplatin.

Thioctic acid na-ejikọ ọla, yabụ, ekwesighi ịkọ ya n'otu oge na ọgwụ ndị nwere ọla (dịka ọmụmaatụ, iron, magnesium, calcium) - oge dị n'etiti doses kwesịrị dịkarịa ala 2 awa.

Site na oge nke thioctic acid na insulin ma ọ bụ ọgwụ hypoglycemic ọgwụ, enwere ike ịbawanye nsonaazụ ha.

Mmanya na metabolites ya na-ebelata ike nke neuroleipone.