Glidiab: ọrịa shuga, contraindications na mmeghachi omume ọjọọ

Mmetụta ọgwụgwọ a na-enweta mgbe ewere Glidiab bụ n'ihi ọrụ nke glycoslide gụnyere na ihe mejupụtara ya, nke bụ usoro nke abụọ sitere na usoro sulfonylurea. N'adịghị ka ọgwụ nke ọgbọ mbụ, a na-eji ike dị ukwuu na nsí ala ya mara ya, na-ekpebi ihe na-ewetara shuga na-ekpebi site n'eziokwu ahụ n'okpuru ike nke gliclazide:

• Enwere mmụba na insulin insulin site na mkpụrụ ndụ beta dị na ntụpọ nke mmadụ, nke, site na iji protein ndị na-anabata ihe, na-eduzi glucose n'ime sel nke anụ ahụ, na-akwalite ịgbalite njikọta nke glycogen na imeju, akwara na igbochi gluconeogenesis,
• A na - egbochi mgbochi nke glucose site na anụ ahụ adipose n'ime imeju.
• A na - eme ka insulin na - agagharị n'ọbara.
• Akpali glucose emeju site na akwara ọkpụkpụ na akwara
• A na - egbochi usoro nke hydrolytic ida nke abụba (lipolysis) na anụ ahụ adipose.

Nyocha nke Glidiab, nke ndị dọkịta na ndị ọrịa chịkọtara, na-egosi na mgbe ị na-a theụ ọgwụ ahụ, a na-eme ka mmetụta nke akwara ahụ dị na insulin na-abawanye, ọrụ nke enzymes intracellular (gụnyere glycogen synthetase ugbu a na akwara akwara) na-akpali, yana oge n'etiti nri ma na-ebelata nke ukwuu. mmalite nke nzuzo site na gland nke secretion nke insulin (yabụ, site na mmụba nke insulin). Ọzọkwa, n'adịghị ka ọgwụ ndị ọzọ bụ sọlfọlu (ma glibenclamide na chlorpropamide) ma nwee mmetụta tumadi n'oge ọkwa nke abụọ nke mmụba, Glidiab na-enyere aka weghachite mbido mbụ nke insulin ma belata ogo glucose n'ọbara.

Na mgbakwunye na emetụta metabolism metabolism, ọgwụ ahụ na-eme ka microcirculation ọbara dịkwuo ala, na-ebelata nrapado platelet na nchịkọta, na-ebelata mmepe nke thrombi parietal.

Na mgbakwunye, dịka ntuziaka ahụ si dị, Glidiab:

• Na-ebelata ihe ndị na-egosi na-emebi emebi vaskụla permeability,
• Ọ na - egbochi mmepe nke microthrombosis,
• Na-ebelata akwara vaskụla na adrenaline,
• Ọ na - eme ka usoro mmebi nke fibrinolysis nke akụkụ ahụ (nke na - egbochi mkpụkọ nke ọbara na ọbara),
• Ọ na-ebelata mkpokọta cholesterol n'ime ọbara, wee si otú a na - ebelata mmepe nke atherosclerosis ma na - akpali mkpali (ya bụ, ọ nwere mmetụta anti-atherogenic),
• Ọ na-egbochi mmepe nke ọrịa mamịrị retinopathy na-abụghị protinerative ogbo.

Nyocha nke Glidiab gosipụtara eziokwu ahụ na ojiji ọ nọ ogologo oge na nephropathy mamịrị nwere ike belata ọdịnaya protein na nyocha mmamịrị.

Ọgwụ a anaghị akpalite mmụba na oke ahụ mmadụ, ebe ọ bụ na ọ na-emetụta mmalite mbụ nke mmepụta insulin site na gland endocrine ma ghara ibute hyperinsulinemia. Glidiab buru ndi oria buru ibu, site na iche, na nri pụrụ iche nwere ike wepu mgbakwunye pound.

Glidiab Pharmacokinetics

Site na nchịkwa ọnụ nke mbadamba Glidiab, ihe dị n'ime ha na-etinye obi gị dum na eriri afọ. Mgbe i aụchara otu ọgwụ ruru 80 mg, a na-ahụta mkpokọta gliclazide dị na plasma ọbara mgbe ihe dị ka awa anọ gachara. Usoro biotransformation na-ewere ọnọdụ na imeju, ebe etolite metabolites asatọ site na ọxọrọ, hydroxylation na glucuronidation na-enweghị ike belata ọkwa glucose, ebe otu n'ime metabolites na-esite na-emetụta microcirculation.

70% nke metabolites na-abụkarị site na akụrụ ya na mmamịrị, ọzọ 12% - yana ihe ndị dị na eriri afọ n’oge mmegharị afọ. Na-agbanweghi site na akụrụ, 1% nke gliclazide na-adị. Iwepu ọkara ndụ na - eme site na awa 8 ruo 11.

Ihe ngosi maka ojiji

Ntuziaka nke Glidiab na-egosi na a na-atụ aro ọgwụ ahụ maka ndị ọrịa na-arịa ụdị ọrịa shuga 2 nke ọrịa obi abụọ na-agafe agafe, yana ụdị microangiopathy na-arịa ọrịa shuga. N'otu oge ahụ, a na-anabata ya ka ọ bụrụ onye na - ahụ maka ọgwụ monotherapeut, yana dịka akụkụ nke usoro ọgwụgwọ siri ike, na - egosi iji ọgwụ ndị ọzọ nwere mmetụta hypoglycemic.

Enwekwara ike inye mbadamba ihe ndị Glidiab na ọgwụ hypoglycemic ndị ọzọ dị ka ọgwụ maka ọrịa dịgasị iche iche nke ọrịa rheology.

Ihe ngbanwe

Ọgwụ nwere contraindications dị iche iche. Yabụ, amachibidoro ịkọwa Glidiab:

• Patientsdị ndị ọrịa shuga 1
• Na ketoacidosis na-arịa ọrịa shuga,
• Site na precca mamịrị shuga
• Ọrịa enweghi nsogbu,
• Ndị mmadụ nwere nnukwu nsogbu gbasara akụrụ na ọrịa ịba ọcha n'anya,
• Na ụdị microangiopathy siri ike,
• Maka ọrịa na-efe efe
• Mmerụ ahụ yana nnukwu ịwa ahụ
• Ndị nwere hyperensitivity si na usoro sulfonylurea na nhazi sulfonamide,
• Womenmụ nwanyị n'oge ime na lact.

Usoro onunu ogwu na nhazi

Maka onye ọrịa ọ bụla, ihe kacha mma kwa ụbọchị nke Glidiab bụ nke ndị dibia na-eleta na-ekpebi ihe dị iche iche dabere na steeti ahụ ya, afọ na ụdị ọrịa ahụ. Karịsịa, ha na-a attentiona ntị na adakarị foto banyere ọrịa na ndị na-egosi ọrịa glycemia, nke a na-ahụ n'ụtụtụ na afọ na-enweghị isi na awa abụọ mgbe nri gasịrị.

Initialzọ mbụ kwa ụbọchị nke Glidiab na-abụkarị 80 mg, nkezi ị na-eme kwa ụbọchị bụ 160 mg, yana kacha bụ 320 mg. Otutu nnabata bu 2. A na-atụ aro mbadamba ị tabletsụ mmanya n'ụtụtụ na n'anyasị ọkara elekere tupu nri.

Nsonaazụ

Nyocha banyere Glidiab bụ ihe akaebe na, n'ọnọdụ ụfọdụ, ị takingụ ọgwụ ahụ nwere ike iso mmeghachi omume ọjọọ.

Patientsfọdụ ndị ọrịa nwere ihe nfụkasị, anorexia, ọgbụgbọ, ọgbụgbọ, mmetụta nke ike na mgbu na mpaghara epigastric. A ga-ahụta Thrombocytopenia, leukopenia, agranulocytosis ma ọ bụ anaemia mgbe ụfọdụ (dịka iwu, ihe ịtụnanya ndị a niile na - atụgharị).

Ngwongwo ogwu

Isi ihe dị na ọgwụ ahụ bụ otu nke ndị ọrịa hypoglycemic, nke ọrụ ya bụ n'ihi nsonaazụ sel nke pancreas. Glidiab na-enye mmetụta dị egwu nke ahụ, dịka:

1. A na-akpali mkpụrụ ndụ nke a na-akpọ pancreatic site na insulin nzuzo.
2. Na-eme ka ọgụgụ anụ dị na insulin, na-enye ohere iji nweta nsonaazụ dị mma mgbe ị useụ ọgwụ mbụ.
3. N’ebelata ogologo oge site n’oge nri batara n’arụ ahụ ruo mgbe akwara na-eme insulin, na-agbari mgbaze n’ihu.
4. Na -ebelata nrapado platelet na nchịkọta, nke na - enyere aka igbochi mmepe nke ọrịa nke akwara obi metụtara njikọ nke ọbara ọgbụgba.
5. Na-ebelata uche nke ndị na-anabata vaskụla na mmetụta nke adrenaline.
6. Na-akpali mbelata proteinuria n'ihu ọnụnọ nephrotic siri ike.

Otu uru dị ukwuu nke ọgwụ ahụ bụ eziokwu bụ na iji ogologo oge were ya, mmụba nke ọrịa na-abawanye n'ahụ ahụ, nke a na-ahụkarị ọnụnọ nke ọrịa shuga mellitus. N’okpuru nri a na-atụ aro, Glidiab na-enyere aka ime ka ahụ sie ike.

Kedu ihe glidiab dị?

Mmepe nke retinopathy na-eji nwayọ nwayọ, nke na-enye onye ọrịa ohere ịnwe ọhụụ. Na-emegide usoro ojiji ogologo oge, microcirculation nke akụkụ ya na-adịwanye mma, nke na-enyere aka belata ngosipụta nke polyneuropathy. N'izi usoro ogwu nri, a gha ebelata ihe oria ya bu oria.

Mgbe ha bukwasịrị mbadamba nkume ndị ahụ n’ime ha, a na-adọpụ ha na ngịga nri, na-abanye n’ọbara ọbara. Mmụba na ịba ụba nke ọgwụ na-eme nwayọ, nke na-ewepụ mmepe nke mmeghachi omume na-adịghị mma site na sistem obi (ọgbụgbọ, dizziness, wdg).

A na-enweta ntinye kachasị ka awa 6-12 ka ewerechara mbadamba. Iri nri anaghị emetụta nnabata na nkesa nke ọgwụ ike.

Ọkara ọkara bụ ihe dịka awa iri na isii. Nke a ga - enyere gị aka ị theụ ọgwụ otu ugboro n'ụbọchị, ịdị ukwuu ya na-adịgide kwa ụbọchị.

Ihe na-arụ ọrụ nke ọgwụ ahụ bụ gliclazide, nke dị na mbadamba ụrọ nwere 30 mg. Ngwa inyeaka:

• microcrystalline cellulose,
• hypromellose,
• silica
• stereta magnesium.

Mbadamba ahụ nwere cylindrical dị larịị nwere chamfer n'etiti. Iri n'ụdị mkpụrụ ndụ 10.

Ihe ngosi maka oge atọrọ

Edere ọgwụ ahụ maka ọnụnọ nke ọrịa shuga 2, yana iwepụ ihe ngosi ndị na-esote:

• ọbara mgbali ike
• Ọrịa obi
• nephrotic syndrome.

Tupu ị theụ ọgwụ ahụ, a na-atụ aro ịgakwuru ọkachamara.

Applicationzọ ntinye

Enwere ụdị Glidiab abụọ: nke mgbe niile na Glidiab MV. Ihe dị iche na nkwadebe bụ naanị na usoro ọgwụgwọ na njiri mara nke nchịkwa.

Ọgwụ mbụ kwa ụbọchị maka ụdị shuga na-aga n’ihu bụ 80 mg kwa ụbọchị. Enwere ike ịbawanye nwayọ na enweghị ọrịa ọgwụgwọ. Oke kachasị kwa ụbọchị nke ọgwụ bụ 320 mg. A na-ekewa ya n'ọtụtụ usoro oge niile, nke na-enye gị ohere ịdobe ọkwa shuga ọbara n'ọkwa ụfọdụ ọbụlagodi mgbe ị carbohydụsịrị carbohydrates.

A na-atụ aro ị takeụ Gladiab ozugbo ị tetara n'ụra jiri ntakịrị mmiri. Na ọnụnọ akụrụ ọrịa akwara, a chọghị imezi usoro onunu ogwu.

Glidiab MV

Ogwu ahu nwere uto uto, ya mere, n’eji otu mbadamba ubochi obula n’otu uzo onodu 30 mg. N’ebe enweghị mmetụta ọgwụgwọ, enwere ike ịkwalite mmụba nke ihe ruru 120 mg kwa ụbọchị. A na-eme usoro a nwayọ, na-agbakwunye ọkara mbadamba ụbọchị kwa izu.

Glidiab MV nwere ogologo ọrụ

A na-atụ aro ịillsụ ọgwụ n’ụtụtụ mgbe nri ụtụtụ ma ọ bụ n’oge nri. Maka enweghị ike, ọ dị mkpa ka ịkpọtụrụ dọkịta banyere ekwe omume idozi usoro usoro onunu ogwu.

Isi uru nke ọgwụ ahụ bụ na enwere ike iji ya na ndị ọzọ hypoglycemic, nke na-adịghị emerụ ahụ ike.

Dodoụbiga ya ókè

N'ihe banyere ịdoụbiga ọgwụ ókè, a na-achọpụta ọnọdụ abụọ dị oke mkpa: hypoglycemia na pancytopenia. N’okwu nke mbụ, shuga dị n’ọbara na-agbadata n’ogo dị ala. N’okwu nke abụọ, ụmị ọkpụkpụ na - agbatị ọsọ ọsọ, nke na - egbochi usoro metabolic niile. N'ịkakọ ọnụ, nke a nwere ike ịkpalite mmepe nke akpịrị na-arịa ọrịa shuga, yana nsonaazụ na-egbu egbu.

Ọ bụrụ na onye ọrịa maara, a na-enye ya nri nwere shuga iji mee ka ọkwa glucose dị n'ọbara. Ọnọdụ amaghị ihe ọ bụla chọrọ ịmịkọrọ glukos na ilele ya mgbe niile nke mmiri ọgwụ nje.

Mmekọrịta na ọgwụ ndị ọzọ

Glibiad MV jikọtara nke ọma na ọgwụ ndị ọzọ nwere akụrụngwa hypoglycemic, mana na ọgwụgwọ dị mgbagwoju anya ọ dị mkpa iburu n'uche ọnụọgụ ọgwụ niile ka ị ghara ịkpasu mmepe nke nnukwu ọbara shuga dị ala.

Site n'iji ọgwụ NSAID mee ihe n'otu oge, enwere hyperemia nke anụ ahụ, pallor na akara ndị ọzọ nke anaemia, gụnyere ọgbụgbọ na enweghị agụụ.

Sulfanilamides na Glibiad na-akpalite ọrịa shuga dị ala, nke na-eme ka ihe ize ndụ nke ibute ọrịa shuga hypoglycemic.

N'iji fibrates mee ihe n'otu oge, akụrụngwa hypoglycemic nke ọgwụ na-abawanye ọtụtụ oge.

Na akpachapụ anya, a na-ejikọta ọgwụ ahụ na glucocorticosteroids, ebe nke ikpeazụ nwere ike ịkpalite mmepe nke ọrịa shuga steroid.

A na-ahọrọ ọgwụ homonụ nke edepụtara iji dozie ọnọdụ nke ọrịa endocrine na ntakịrị usoro, ebe ọ bụ na mgbe gị na Glidiab na-emekọrịta, usoro ọgwụgwọ nke ikpeazụ ahụ na-ebelata ọtụtụ oge.

Theophylline na ihe ndị a na-enweta salicylic acid ọtụtụ oge na-eme ka ọgwụ dịkwuo mma, nke nwere ike ịkpalite mmepe nke hypoglycemia.

Amachibidoro ya kpamkpam ijikọ Miconazole na ọgwụ antifungal ndị ọzọ na Glidiab

A machibidoro iwu ijikọ Miconazole na ọgwụ mgbochi antifungal ndị ọzọ na Glidiab, nke gụnyere mmepe nke coma mamịrị na nsonaazụ na-akpata ọnwụ.

Ọzọkwa, ejila ọgwụ na tinctures maka mmanya, dị ka ụmụ irighiri ethanol na-akpalite imebi akụrụngwa nke ahụ, na-emetụta ọria.

Ndị na-egbochi Adrenergic na kọntaktị na Glidiab na-enwe ike ikpuchi ihe ịrịba ama nke hypoglycemia, nke na-abawanye ihe ize ndụ nke ịmalite ọnọdụ ọnọdụ mberede.

Barbiturates fọrọ nke nta ka ọ gbochie ọrụ Glidiab MV nke ọgwụ, ya mere, ejikọghị ha ọnụ n'ihi enweghị ọgwụgwọ ọgwụgwọ nke ikpeazụ ahụ.

N'okpuru ndụmọdụ niile nke ọkachamara, Glidiab mbadamba nwere ike inye aka belata ọkwa shuga dị elu, yana belata ngosipụta nke ọrịa shuga. Ekwesịrị ịwepụ onwe gị ọgwụ, ebe enwere nnukwu ihe ize ndụ nke ịmalite mmeghachi omume ọjọọ.