Gabapentin - ntuziaka maka ojiji na nyocha

Nkọwa nke metụtara 04.02.2015

• Aha Latin: Gabapentin
• Koodu ATX: N03AX12
• Arụ Ọrụ: Gabapentin
• Emeputa: PIK-PHARMA, Canonfarm Production CJSC (Russia), Aurobindo Pharma (India), Erregierre S.p.A. ()Tali)

Na capsu 1 gabapentin 300 mg

Calcium hydrogen phosphate, stachi nduku, macrogol, magnesium stearate - dị ka ndị nke ochie.

Ihe ngosi maka ojiji

• monotherapy ihe ọdịdọ na Akwụkwụ na-adọ n'ime ndị okenye na ụmụaka site na afọ 12,
• ọgwụgwọ ọzọ ihe ọdịdọ Akwụkwụ na-adọ ndị okenye,
• ọgwụgwọ ọzọ Akwụkwụ na-eguzogide ọgwụ n'ime ụmụaka gbara afọ 3,
• migraine,
• ihe mgbu neuropathic (neuralgia postherpetic, ọrịa shuga, trigeminal, ihe metụtara nje HIV, onye aholicụrụma, yana spine stenosis),
• mbelata na ike nke ebili mmiri n’oge menopause.

Ihe ngbanwe

• nkọ ọria aru,
• hypersensitivity na ọgwụ,
• galactose anagide ma ọ bụ anabataghị glucose na galactose,
• afọ ruo afọ atọ na ọdụ ọdịdọ
• afọ ruru afọ iri na abụọ site na postherpetic neuralgia,
• tụụrụ ime.

Nsonaazụ

• abawanye EGO, tachycardia,
• dyspepsia, ọgbụgbọ, afọ mgbu, akpọnwụ akpịrị, anorexia, afọ ntachi ma obu afọ ọsịsa, ọria aru, flatulence, gingivitis,
• myalgiaazu mgbu
• iro ụra, anya ntughari, nystagmusmụbara ike ọgwụgwụna excitability, dysarthria, gtin mgbu, obi utondaba hyperkinesia,ụjọ, ehighị ụra,
• rhinitis, ọrịa ụkwara nta, ụkwara,
• urinary incontinence, enweghi ike,
• nkwarụ anya, tinnitus,
• anụ ahụ ihe nwumgbanye erythema,
• Igha ibu, Ihu iru, ọzịza.

Mmekorita

Anabatachara ka iji ọgwụ ọgwụ ndị ọzọ emeghakwa oge (Phenobarbital, Carbamazepine, Phenytoin, Acproic Acid) na ọgwụ mgbochi ọnụ. N'okwu a, ọgwụ ọgwụ nke gabapentin adịghị agbanwe.

Antacids na-ebelata ọgwụ bioavailability nke ọgwụ ahụ, yabụ ị theụ ọgwụ ọjọọ na ọgwụ antacids na-agbasa oge.

Ọgwụ Myelotoxic na-abawanye hematotoxicity nke gabapentin.

Na njikọta ya morphine ọgwụ ọgwụ morphine agbanwebeghị. Agbanyeghị, enwere ike nyochaa mmeghachi omume na-adịghị mma site na sistemụ akwara nke etiti.

Alcoholụ mmanya na-egbu egbu nwere ike ịbawanye mmeghachi omume ọjọọ site na sistemụ akwara nke etiti (ataxia, nzuzu).

Ntụziaka pụrụ iche

Ọ bụrụ na ọ dị mkpa ịkagbu ọgwụ ahụ, a ga-ebu ụzọ belata mbelata nke mkpụrụ ọgwụ (n’ime izu 1-2), ebe ọ bụ na ịkwụsị ịgwọ ọrịa ahụ nwere ike ịkpalite epistatus. N'oge afọ ime, o nwere ike iji ya dabere n'ihe ngosipụta siri ike, mgbe uru nne baara karịa nwa ebu n’afọ.

Ọ bụrụ na ataxia, dizzness, bodyribness, ihi ụra na-egosi na ndị okenye, na iro ụra na iro nke ụmụaka, ekwesịrị ịkwụsị ya. N'oge ọgwụgwọ, ịkwesịrị ịkwọ ụgbọala.

Mwepụta wepụtara ya na ọgwụ mejupụtara

Gabapentin dị n'ụdị capsule maka nchịkwa ọnụ. A na-etinye ọgwụ ahụ na Mkpọ 50 na mbadamba 100 ma ọ bụ na blisters nke 10 -15 iberibe na igbe kaadi.

Capsule nke ọ bụla nwere ihe na - arụ ọrụ - gabapentin 300 mg, yana ọtụtụ ihe inyeaka: calcium stearate, gelatin, titanium dioxide, microcrystalline cellulose.

Jiri na usoro ahụike

Emepụtara Gabapentin na Parke-Davis ma buru ụzọ kọwaa ya na 1975. N'okpuru akara ngosi Neurontin, ekwesiri ibu ụzọ mee ya na Mee 1993 maka ịgwọ ọrịa akwụkwụ na UK ma ree ya na United States na 1994. Mgbe nke a gasịrị, akwadoro n'ihupentin na United States maka ịgwọ ọrịa neuralgia postherpetic na May 2002. N’ọnwa Jenụwarị afọ 2011, United States kwadobere ụdị nnabata gaba n’ihu maka ọgwụ nchịkwa otu ugboro ka aha ya bụ Gralise. Gabantine anacarbil n'okpuru ụdị aha Horizant, nke nwere bioavailability dị elu, ka ewebata ya na United States maka ịgwọ ọrịa ụkwụ na-enweghị nsogbu na Eprel 2011 wee kwado ya maka ọgwụgwọ nke postelpetic neuralgia na June 2012.

Jiri na usoro ahụike

A na-ejikarị Gabapentin iji gwọọ ọdụdọ na obi mgbu. Ọ bụ ọnụ ka a na-ahụ maka ya, yana nyocha gosiri na "nchịkwa nchịkwa anaghị enye afọ ojuju." Ọ bụkwa iwu ka edere maka ọtụtụ ngwa ndị a na-edeghị aha, dịka ọgwụgwọ nke nsogbu ụjọ, nsogbu ehighị ụra na ọrịa uche. Agbanyeghị, enwere nchegbu banyere ịdị mma nke nnwale ndị a mere na ihe akaebe maka ụfọdụ ngwa ndị a, ọkachasị mgbe ejiri ya dịka ọnọdụ ihe na-agbanwe ọnọdụ ọgbaghara.

Ngwá ọgwụ ọgwụ

Gabapentin bụ ọgwụ nwere ọgwụ anticonvulsant akpọsa. N'okpuru mmetụta nke ọgwụ ahụ na ndị ọrịa nwere àkwụkwụ na-adọ, ọ na-ebelata ihe ize ndụ nke ịmalite ọgụ ugboro ugboro.

A na-eji ọgwụ a agwọ ndị okenye na ụmụaka maka ọgwụgwọ nke akwụkwụ na ihe mgbu neuropathic megide ndabere nke shingles.

Mlọ ọgwụ

Na nhazi, gabaptiin yiri GABA neurotransmitter (gamma-aminobutyric acid), mana usoro ya si dị iche na ọgwụ ndị ọzọ na-emekọrịta ndị na-anabata GABA (valproic acid, barbiturates, benzodiazepines, GABA transtake inhibitors, GABA transaminase inhibitors, and agonists of agonists of GABAamin) Gdị GABA).

Gabapentin enweghị GABAergic Njirimara ma ọ naghị emetụta mmelite na metabolism nke GABA. Dabere na nyocha nke mbido, ihe a na-ejikọ ọnụ α₂-δ-subunit nke ọdụdụ calcium na-agbanye ike ma belata njupụta nke ciumdị calcium, nke na-arụ ọrụ dị mkpa na mmepe nke ihe mgbu neuropathic.

Usoro ndị ọzọ maka ime ihe na - egbu mgbu:

• mụbaa GABA,
• mbelata na ọnwụ na-adabere n'ihe ọgbụgbọ na akwara,
• mgbochi nke mwepụta nke neurotransmitters nke monoamine otu.

N’ime oganihu putara ihe nke ulo ogwu nke ndi ozo nke ndi ozo n’eji ogwu ma obu ndi n’ile ya anya._NaGABA_A, glycine, glutamate, N-methyl-D-aspartate, ma ọ bụ ndị na-anabata benzodiazepine, anaghị ejikọ.

Gabapentin, n'adịghị ka carbamazepine na phenytoin, anaghị emekọrịta na ọwara sodium na vitro. N'oge ọgwụgwọ vitro, ụfọdụ nyocha nke vitro na-egosi nyocha nke akụkụ nke mmetụta glutamate receptor agonist N-methyl-D-aspartate, mana ọ bụ naanị na ịta>> 100 μmol, nke a na-enweta na vivo. Gabapentin dị ntakịrị belata mwepụta nke neurotransmitters monoamine.

Mlọ ọgwụ

Nkpukpo ndu nke nmechu abughi ihe dabere na okike n’enweghi nsogbu na-abawanye. C_max kachasi itinye uche n'ihe ahuruaja n'ihu na plasma ka ejirichara onu ghaa aka mee ihe n’awa 2-3. Ezigbo bioavailability dị ihe dịka 60%. Nri, gụnyere ịnwe oke abụba, anaghị emetụta oke ọgwụ ọgwụ ọgwụ.

A na-akọwa ikpochapụ ihe ndị dị na plasma site na iji usoro kwụ ọtọ. Ndi_1/2 (iwepụ ọkara ndụ) sitere na plasma nkezi nke awa 5-7 ma ọ dabereghị na dose ahụ. Site n'iji ya ugboro ugboro, ọgwụ pharmokokinetic adịghị agbanwe. Enwere ike ịkọ uru ogo ndọta plasma na-adabere na nsonaazụ nke otu ọgwụ ọgwụ.

Gabapentin fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein (80 - 900-2400 mg) kwa ụbọchị,