Telmista 80 mg - ntuziaka maka ojiji

Telmista 80 mg - ọgwụ antihypertensive, onye na - emegide ụzọ nnabata angiotensin II (ụdị AT1).

1 mbadamba 80 mg:

Ngwakọta ọrụ: Telmisartan 80.00 mg

Ndị pụrụ iche: meglumine, sodium hydroxide, povidone-KZO, lactose monohydrate, sorbitol (E420), magnesium stearate.

Mbadamba 80 mg: Mpekere-acha uhie uhie, mbadamba biconvex nke acha ọcha ma ọ bụ ụcha ọcha.

Mlọ ọgwụ

Telmisartan bụ onye antagonistin nke abụọ na-anabata ihe nnweta (ARA II) (ụdị AT1), dị irè mgbe a na-ewere ya ọnụ. Ọ nwere oke mmekọrịta dị mma maka AT1 subtype nke ndị na-anabata angiotensin II, site na nke a na-ahụ ihe omume nke angiotensin II. Na-egosiputa angiotensin nke II site na njikọ ya na onye na-anabata ihe, na-ejighi ihe onye na-atụgharị uche na nnabata a. Telmisartan na ejikọ naanị AT1 ụdị nke ndị nnabata angiotensin II. Njikọ ahụ na-aga n'ihu. O nweghi nmekorita ya nye ndi nnabata ozo, tinyere ndi nnabata AT2 na ndi nnabata angiotensin di obere. Ọdịghị uru ọrụ nnabata ndị a bara, yana nsonazụ ha nwere ike ime nke ọma na angiotensin nke abụọ, amụbeghị nke ọ na-abawanye na iji telmisartan. Ọ na-ebelata mkpụkọ nke aldosterone na plasma ọbara, anaghị egbochi mmiri renin na plasma ọbara na ns mgbochi ion. Telmisartan anaghị egbochi angiotensin ntụgharị enzyme (ACE) (kininase II) (enzyme nke na-akụda bradykinin). Yabụ, atụghị anya mmụba nke mmetụta n'akụkụ bradykinin kpatara.

N'ime ndị ọrịa, telmisartan na ọgwụ nke 80 mg kpamkpam egbochi mmetụta ọbara mgbali nke angiotensin II. A na-ahụ mmalite mmalite nke ọgụ ọgwụ mgbochi n'ime awa 3 mgbe nchịkwa izizi nke telmisartan. Mmetụta ọgwụ ahụ na-adịgide ruo awa 24 ma na-adịgide ruo 48 awa. A na - enwekarị mmetụta antihypertensive na - amalitekarị mgbe izu 4-8 gachara nke sistemụ telmisartan.

N'ime ndị ọrịa nwere ọbara mgbali elu, telmisartan lowers systolic na ọbara mgbali ọbara (BP) na-enweghị emetụta mmetụ obi (HR).

N'ihe banyere kagbuo telmisartan na mberede, ọbara mgbali jiri nwayọ laghachi ọkwa mbụ ya na enweghị mmepe nke ọrịa "ndọrọpụ".

Mlọ ọgwụ

Mgbe a na -ewere ya n’ọnụ, ọ na-ewe iwe ngwa ngwa site na eriri afọ (GIT). Bioavailability bụ 50%. Mbelata nke AUC (mpaghara n'okpuru oge ịta ahụhụ) na ojiji nke telemisartan na nri sitere na 6% (na dose 40 mg) ruo 19% (na dose 160 mg). 3 awa mgbe ịbatara, ịta na plasma ọbara na-abụ nke ọma, n'agbanyeghị oge iri nri. Enwere ọdịiche na mkpokọta plasma na ụmụ nwoke na ụmụ nwanyị. Ntinye uche kachasị (Cmax) na plasma ọbara na AUC n'ime ụmụ nwanyị jiri ihe dịka ụmụ nwoke ruru ihe dịka ugboro atọ na ugboro abụọ, otu (na-enweghị nnukwu mmetụta na arụmọrụ).

Nkwukọrịta na protein protein plasma - 99.5%, tumadi na albumin na alfa-1 glycoprotein.

Ogo nke ogo ihe pụtara ìhè n’inweta nha anya bụ lita 500. A na-agagharị ya site na conjugation na glucuronic acid. Metabolites anaghị arụ ọrụ ọgwụ. Ọkara ndụ (T1 / 2) karịrị awa 20. Ọ bụpịrị ya site na eriri afọ n'ụdị agbanweghị ya na akụrụ ya - na-erughị 2% nke ọgwụ a .ụrụ. Mkpokọta plasma zuru oke (900 ml / min), mana e jiri ya tụnyere ọbara ọria “hepatic” (ihe dị ka 1500 ml / min).

Ihe ngbanwe

Ihe ndị a na-egbochi ndị a na-akpọ ọgwụ Telmista:

• Ejikọtara mmụọ na-arụ ọrụ ma ọ bụ ndị nwe ọgwụ ahụ.
• Ime
• Oge ịfeụ ara.
• Ọrịa na-egbochi ọnya biliary.
• Ọrịa hepatic siri ike (-mụaka-Pugh klas C).
• Ekwekọrịta na aliskiren n'ime ndị ọrịa nwere ọrịa mellitus ma ọ bụ agafeghị oke oke akụrụ gbasara ọdịda (ọnụego mkpokọta ụwa (GFR))

Nsonaazụ

Ọnọdụ ndị a chọpụtara na nsonaazụ ndị ọzọ emetụtaghị na okike, afọ ma ọ bụ agbụrụ ndị ọrịa.

• Ọrịa na-efe efe na ọrịa nje: sepsis, gụnyere sepsis na-egbu egbu, ọrịa urinary tract (gụnyere cystitis), ọrịa akụkụ akụkụ okuku ume na elu.
• Ọrịa sitere na ọbara na sistem lymphatic: anaemia, eosinophilia, thrombocytopenia.
• Ọrịa sitere na usoro ahụ ji alụso ọrịa ọgụ: mmeghachi omume anaphylactic, hypersensitivity (erythema, urticaria, angioedema), eczema, itching, ọnya anụ ahụ (gụnyere ọgwụ), angioedema (yana ihe na-egbu egbu), hyperhidrosis, friji akpụkpọ ahụ na-egbu egbu.
• Mmebi nke usoro ụjọ ahụ: nchekasị, ehighị ụra nke ọma, ịda mba, nkụda mmụọ, vertigo.
• Ọkpụkpụ nke akụkụ nke ọhụhụ: ọgba aghara.
• Mmebi nke obi: bradycardia, tachycardia.
• Mmebi nke arịa ọbara: mbelata nke ọbara mgbali elu, orthostatic hypotension.
• Ọrịa dị iche iche nke akụkụ iku ume, akụkụ ahụ na ọba: mkpirisi iku ume, ụkwara, ọrịa ngụgụ * (* n'oge azụ ahịa iji kọwaa ọrịa gbasara ọrịa ngụgụ, yana njikọta oge na telmisartan.Ta agbanyeghị, enweghị mmekọrịta na-esite na iji telmisartan etinyela).
• Ọrịa digestive: mgbu afọ, afọ ọsịsa, mucosa a na-ede ede, dyspepsia, flatulence, erughi ala, vomiting, perversion (dysgeusia), ọrụ imeju na-egbu / ọrịa imeju * (* dị ka nsonaazụ nke nlele mgbere ahia ka otutu Achọpụtala ọrịa gbasara ọrịa imeju na-arịa mmadụ / ọrịa imeju ka ndị Japan.
• Ọrịa sitere na akwara na uru ahụ: arthralgia, azụ mgbu, akwara nke (nchikota akwara nke nwa ehi), ihe mgbu na nsọtụ nke ala, myalgia, mgbu akaị (mgbaàmà ndị yiri nke gosipụtara akwara).
• Nsogbu sitere na akụrụ na akwara: arụrụ ọrụ gbasara akụrụ, gụnyere nnukwu akụrụ gbasara akwara.
• Ọrịa na nkwarụ izugbe na ntanetị: mgbu obi, nrịanrịa dịka ọrịa, adịghị ike izugbe.
• Data laabu na akụrụngwa: mbelata hemoglobin, mmụba nke mkpo uric acid, creatinine na plasma ọbara, mmụba na ọrụ nke "imeju" enzymes, creatine phosphokinase (CPK) na plasma ọbara, hyperkalemia, hypoglycemia (na ndị ọrịa nwere ọrịa mellitus).

Mmekọrịta na ọgwụ ndị ọzọ

Telmisartan nwere ike iwelie mmetụta antihypertensive nke ọgwụ ọgwụ antihypertensive ndị ọzọ. Achọpụtaghị ụdị mmekọrịta ndị ọzọ dị mkpa nke ụlọ ọgwụ.

Ojiji ichoro ya na digoxin, warfarin, hydrochlorothiazide, glibenclamide, ibuprofen, paracetamol, simvastatin na amlodipine adighi eduga na mmekorita di egwu banyere ogwu. Mmụba dị ịrịba ama na nkezi nke digoxin na plasma ọbara site na nkezi 20% (n'otu oge, pasent 39%). N'iji telmisartan na digoxin, n'otu oge, ọ ga-adị mma ka ị chọpụta oge digoxin na plasma ọbara.

Dịka ọgwụ ndị ọzọ na-arụ ọrụ na sistemụ renin-angiotensin-aldosterone (RAAS), ojiji nke telmisartan nwere ike ịkpata hyperkalemia (lee akụkụ "ntuziaka pụrụ iche"). Ihe ize ndụ ahụ nwere ike ịbawanye elu ma a na-eji ọgwụ ndị ọzọ n'otu oge, nke nwekwara ike ịkpasu mmepe nke hyperkalemia (nnọchi nnu nke nwere potassium, ọgwụ na-egbochi ọgwụ, ndị na-egbochi ACE, ọgwụ ARA II, NSAIDs na-abụghị steroidal anti-inflammatory ọgwụ), gụnyere cyclooxygenase-2 | TsOGG-2 | immunosuppressants cyclosporine ma ọ bụ tacrolimus na trimethoprim.

Mmepe nke hyperkalemia dabere n'ihe ndị dị ize ndụ. A na - amụba ihe ize ndụ ahụ maka iji otu oge ejikọtara ọnụ ndị dị n'elu. Karịsịa, ihe ize ndụ ahụ dị elu karịa mgbe ejiri ya na ọgwụ ndị na-enye potassium, yana ndị na-eji nnu ndị nwere nnu. Dịka ọmụmaatụ, iji ya na ACE inhibitors ma ọ bụ NSAIDs nwere obere nsogbu ma ọ bụrụ na-akpachara anya. ARA II, dika telmisartan, na-ebelata oke ahihia na - egbu oge a na - eme ya ihe diuretic. Iji ọgwụ ndị na-eme ka potassium na-eme ka ihe atụ dịkwuo, spironolactone, eplerenone, triamteren ma ọ bụ amiloride, ihe ndị nwere potassium ma ọ bụ ndị nwere nnu nnu nwere ike ime ka mmụba dị ukwuu na potassium. Aga-eji otu oge, nke ejiri ọgwụ hypokalemia edekọ na-akpachara anya ma jiri nlezianya nyochaa potassium na plasma ọbara. Site na iji telmisartan na ramipril na-eme n'otu oge, a hụrụ mmụba nke okpukpu abụọ na AUC0-24 na Cmax nke ramipril na ramipril. Egosipụtaghi mkpa ogwu di egwu a. N'iji oge nke ACE inhibitors na nkwadebe lithium, a hụrụ mmụba na-agbanwe agbanwe na ọdịnaya plasma lithium, yana nsonaazụ ndị na-eso ya. N'ọnọdụ ndị a na-adịghị ahụkebe, a kọọrọ mgbanwe ndị dị otú ahụ na nkwadebe ARA II na lithium. N'iji oge nke lithium na ARA II, a na-atụ aro iji chọpụta ọdịnaya lithium dị na plasma ọbara. Ofgwọ NSAIDs, gụnyere acetylsalicylic acid, COX-2, na NSAIDs na-adịghị ahọrọ, nwere ike ibute nnukwu ọrịa gbasara ọrịa na-arịa ọrịa ọrịa akpịrị. Ọgwụ na-eme ọgwụ na RAAS nwere ike ịnwe mmetụta synergistic. N'ime ndị ọrịa na-anata NSAIDs na telmisartan, bcc ga-akwụghachi ụgwọ na mbido ọgwụgwọ na ọrụ gbasara akụrụ. Ekwekọrịta na aliskiren n'ime ndị ọrịa nwere ọrịa mellitus ma ọ bụ agafeghị oke oke akụrụ ọdịda (ọnụ ahịa mkpokọ nke GFR