Mikstard® 30 NM Penfill® Ogologo oge insulin mmadụ na-agwakọta na insulin na-adị obere oge

Hypoglycemic n'ụlọnga nke ọkara oge. Ọ na - emekọrịta otu onye na - anabata ihe n'ụsọ akpụkpọ ahụ ma mepụta ebe nnabata insulin dị. Site na ịgbalite biosynthesis nke cAMP na mkpụrụ ndụ abụba na mkpụrụ ndụ imeju ma ọ bụ abanye n'ime mkpụrụ ndụ akwara, ihe nnabata isulin na-akpali usoro intracellular, gụnyere njikọ nke ọtụtụ enzymes isi (hexokinase, pyruvate kinase, glycogen synthetase, wdg). Mbelata mgbanye nke glucose n'ọbara bụ n'ihi mmụba nke ụgbọ njem intracellular ya, gụnyere mmụba na uru anụ ahụ, mkpali nke glycogenesis, glycogenogenesis, protein protein, belata mmepụta glucose site na imeju, wdg.

Ogologo oge nke insulin eme ihe bụ n'ihi ọnụego mmiri, nke na-adabere na ọtụtụ ihe (gụnyere dose, usoro na ebe nchịkwa). Mmalite nke imechara mgbe sc nchịkwa dị na nkeji iri atọ, nsonaazụ kachasị na-ebilite na awa 2-8, oge a ga-eme ihe dị ka awa 24. Oge etinyere na ngwakọta insulin na-eme obere oge.

Nsonaazụ

Mmeghachi omume nfụkasị ahụ (urticaria, angioedema - fever, ure ume ọkụ, mbelata ọbara mgbali), gụnyere mpaghara (hyperemia, ọzịza, itching nke anụ ahụ na ntụtụ ebe), lipodystrophy na saịtị ịgba ntụtụ, hypoglycemia (pallor nke anụ ahụ, ịba ụba, ịsụsọ, palpitations, ịma jijiji, agụụ, oke iwe, nchekasị, paresthesia na ọnụ, isi ọwụwa, iro ụra. , nsogbu ehighị ụra, ụjọ, ọnọdụ obi erughị ala, oke mgbakasị ahụ, omume na-enweghị atụ, enweghị ntụkwasị obi nke mmegharị, isi okwu na ọhụhụ), coma hypoglycemic.

Na nmalite ọgwụgwọ - mgbakasị ahụ na mgbakasị ahụ (na-adị nwa oge ma na-apụ n'anya site na iji ọgwụgwọ na-aga n'ihu).

Ngwa na usoro onunu ogwu

S / c nọ na mpaghara apata ụkwụ (ebe a na-ewere nwayọ nwayọ na nke ị uniformụ ọgwụ ọ )ụ itụ), a na-ahapụkwa ya s / c iwere na ogwe aka dị n’afọ, buttock ma ọ bụ mpaghara mpaghara akwara dị n’ubu.

Ọ bụ dọkịta ga-ekpebi ọ̀tụ̀tụ̀ ọgwụ ahụ n’otu n’otu n’okwu ọ bụla dabere n’ọbara glucose n’ọbara. Ogologo ubochi ubochi sitere na 0,5 ruo 1 IU / kg body. A na-enye ọgwụ ahụ nkeji iri atọ tupu nri nwere carbohydrates. Okpomoku nke okpomoku okpomoku aghaghi ibu okpomoku ulo.

Perrụpụta ntụtụ n’akpụkpọ ahụ na-ebelata ohere ịbanye n’olu.

Okwesiri igbanwe ebe ogwu ngbanyere na mpaghara anatomical iji gbochie mmepe nke lipodystrophy.

A na-eji ọgwụ ahụ eme ihe dị ka monotherapy yana yana insulin na-adị mkpụmkpụ. Site na usoro ọgwụgwọ siri ike, a na-eji ọgwụ ahụ eme ihe dị ka insulin insulin 1-2 ugboro n'ụbọchị (mgbede na nlekọta ụtụtụ) yana insulin na-eme obere oge (nchịkwa tupu nri ehihie).

Na ụdị ọrịa shuga II nke ọrịa mellitus, a na-enye ọgwụ ahụ yana ọgwụ hypoglycemic nke ọnụ.

Ntụziaka pụrụ iche

Enweghị ike ịbanye ọgwụ ahụ na / na.

Na ntinye nke insulin kwesiri ileba anya mgbe odi nso glucose na obara.

Ọgwụ ahụ ekwesighi ma ọ bụrụ na, mgbe ọ malikịrị, nkwusioru ahụ anaghị acha ọcha ma yie ndị ojii. N'ihi iwebata ọgwụ adịghị atụ aro iji nfuli insulin.

Enwere ike wepu hypoglycemia site na ịnweta shuga ozugbo ma ọ bụ ụfọdụ ngwaahịa nwere shuga (onye ọrịa ahụ ga-enwerịrị iberibe shuga, swiiti, kuki ma ọ bụ ihe ọ fruitụ fruitụ mkpụrụ osisi mgbe niile).

Gwa ndị ikwu, ndị enyi na ndị ọrụ ibe gị ozugbo banyere ọrịa shuga, kọwaa iwu maka enyemaka mbụ ọ bụrụ na nnukwu ọrịa hypoglycemia.

Site na ntinye nke obere insulin karịa ka ọ dị mkpa, ịrị elu insulin ịba ụba, enweghị nri, yana nchịkwa insulin, hyperglycemia na ketoacidosis na-arịa ọrịa shuga nwere ike ịmalite (polyuria, pollakiuria, akpịrị ịkpọ nkụ, agụụ, agụụ, ọgbụgbọ, vomiting, ụra, adịghị ike, hyperemia, na akpukpo aru, akpukpo nku na isi nke acetone n’enye ikuku). Mgbe ihe ịrịba ama mbụ nke hyperglycemia pụtara, a ga-enye insulin ozugbo.

Na ọrịa concomitant (gụnyere imebi gland thyroid, imeju, akụrụ, ọrịa Addison, hypopituitarism) na ndị agadi (ihe karịrị afọ 65), enwere ike ịchọ mgbanwe mgbanwe insulin. Ọrịa ọnya na-efe efe na ọnya, ịba ụba na mmega ahụ, mgbanwe na nri iri nri na-abawanye mkpa ịchọrọ insulin.

Ntinye nri Ethanol (gụnyere biya, mmanya) nwere ike ibute hypoglycemia. Ejila ethanol na akwa efu.

Mgbe ị na-agbanye insulin nke mmadụ, ekwesịrị iburu n'uche na mmalite nke mgbaàmà nke ndị na-abingụ hypoglycemia nwere ike ghara ịdị na-ekwusi ike karịa ka ha na-eme mgbe ị na-eji ọgwụ ị na-a .ụ. Ọdịdị na ịdị ukwuu nke mgbaàmà ndị a nwere ike gbanwee n'oge oge ụgwọ kwụrụ ụgwọ maka metabolism metabolism (gụnyere n'oge ọgwụgwọ insulin siri ike).

N’ime ime na n’oge a na-enye nwa ara, a na-atụ aro idozi ọnya iji dozie ụgwọ maka ọrịa shuga.

N'oge usoro ọgwụgwọ, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike ịdị ize ndụ chọrọ mmụba nke nlebara anya na ọsọ nke mmeghachi omume psychomotor (n'oge hypoglycemia, ha nwere ike ibelata).

Mmekorita

N ’ogwu ọgwụ ekwekọghị na ọgwụ nke ọgwụ ndị ọzọ.

A na - eme ka mmetụta hypoglycemic dị na sulfonamides (gụnyere ọgwụ hypoglycemic ọgwụ, sulfonamides), MAO inhibitors (gụnyere furazolidone, procarbazine, selegiline), ndị na-egbochi carbon anhydrase inhibitors, ndị na-egbochi ACE, ndị na-egbochi NSAIDs (gụnyere salicylates), anabolic (gụnyere stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, phenfluramine, Li +, pyridoxine, quinidine, quinine, chloroquin.

Hypoglycemic mmetụta nke isi glucagon, ibu hormone, corticosteroids, onu gbochie afọ, estrogens, thiazide na loop diuretics, BCCI, thyroid homonụ, heparin, sulfinpyrazone, sympathomimetics, danazol, tricyclics, clonidine, calcium na-akụ ọkpọ, diazoxide, morphine, wii wii, nicotine, phenytoin, epinephrine, H1-histamine na-anabata ihe mgbochi.

Beta-egbochi, reserpine, octreotide, pentamidine nwere ike ịkwalite ma mee ka ike gwụ hypoglycemic mmetụta nke insulin.

Diabetologist: "Ka imezi ọkwa shuga dị n'ọbara."

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

S / c nọ na mpaghara apata ụkwụ (ebe a na-ewere nwayọ nwayọ na nke ị uniformụ ọgwụ ọ )ụ itụ), a na-ahapụkwa ya s / c iwere na ogwe aka dị n’afọ, buttock ma ọ bụ mpaghara mpaghara akwara dị n’ubu.

Ọ bụ dọkịta ga-ekpebi ọ̀tụ̀tụ̀ ọgwụ ahụ n’otu n’otu n’okwu ọ bụla dabere n’ọbara glucose n’ọbara. Ogologo ubochi ubochi sitere na 0,5 ruo 1 IU / kg body. A na-enye ọgwụ ahụ nkeji iri atọ tupu nri nwere carbohydrates. Okpomoku nke okpomoku okpomoku aghaghi ibu okpomoku ulo.

Perrụpụta ntụtụ n’akpụkpọ ahụ na-ebelata ohere ịbanye n’olu.

Okwesiri igbanwe ebe ogwu ngbanyere na mpaghara anatomical iji gbochie mmepe nke lipodystrophy.

A na-eji ọgwụ ahụ eme ihe dị ka monotherapy yana yana insulin na-adị mkpụmkpụ. Site na usoro ọgwụgwọ siri ike, a na-eji ọgwụ ahụ eme ihe dị ka insulin insulin 1-2 ugboro n'ụbọchị (mgbede na nlekọta ụtụtụ) yana insulin na-eme obere oge (nchịkwa tupu nri ehihie).

Na ụdị ọrịa shuga II nke ọrịa mellitus, a na-enye ọgwụ ahụ yana ọgwụ hypoglycemic nke ọnụ.

Mpempe usoro onunu ogwu

Nkwụsịtụ maka nchịkwa subcutaneous, 100 IU / ml

1 ml nke ọgwụ nwere

ike - mkpụrụ ndụ ihe nketa insulin mmadụ 3.50 mg (100 IU) 1,

ndị na-ebu ụzọ: zinc (n'ụdị nke zinc chloride), glycerin, phenol, metacresol, sodium hydrogen phosphate dihydrate, sulfate protamine, hydrochloric acid 2 M, sodium hydroxide 2 M ngwọta nke pH 7.3, mmiri maka injection.

1 Ọgwụ ahụ nwere insulin mmadụ na-eme 30% na 70% isofan-insulin

Nkwụghachi ọcha ahụ, mgbe ọ na-eguzo ọtọ, na-agbanwe ka ọ bụrụ onye na-enweghị atụ, enweghị agba ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke enweghị agba na ọkwa ọcha. A na - eji nwayọ nwayọ were weghachite ihe omume.

Ngwongwo ogwu

Mlọ ọgwụ

Ogologo oge nke ihe insulin na-eme bụ n'ihi nzere, nke dabere na ọtụtụ ihe (dịka ọmụmaatụ, na insulin insulin, usoro na ebe nlekọta, ọkpụrụkpụ nke subcutaneous abụba oyi akwa na ụdị ọrịa shuga mellitus). Yabụ, ọgwụ ọgwụ insulin nke gọọmentị na-enwe mgbanwe dị iche iche na-emetụta mmadụ.

A na - enweta insulin na plasma nke kachasị (Cmax) n'ime awa 1.5 ruo 2.5 mgbe nchịkwa subcutaneous gasịrị.

O nweghị ihe akpọrọ ihe na-egbochi protein amasara ahụ, ewezuga ọgwụ mgbochi insulin (ọ bụrụ na ọ dị).

A na-ewepụ insulin mmadụ site na ọrụ nke insulin protease ma ọ bụ enzymes na-eme ka insulin na-ehichapụ ya, na ikekwe sitekwa n'ọrụ protein disulfide isomerase. Echere na na molekul nke insulin mmadu nwere otutu saịtị nke cleavage (hydrolysis), agbanyeghị, ọ nweghị nke metabolites guzobere n'ihi nsachapụ adịghị arụ ọrụ.

Ndụ ọkara (T½) kpebisiri ike ịnwe nzere site na anụ ahụ dị n'okpuru ala. Ya mere, T½ bu ihe ozo banyere nnabata, karie ihe ozo banyere iwepu insulin na plasma (T½ nke insulin n’aru obara bu obere oge). Mmụta emere gosiri na T½ bụ ihe dịka awa 5-10.

Mlọ ọgwụ

Mikstard® 30 NM Penfill® bụ insulin nke na-arụ ọrụ ugboro abụọ site na usoro ihe omimi nke ihe omimi nke DNA na-eji Saccharomyces cerevisiae eme ihe. Ọ na - emekọrịta otu onye na - anabata ihe n'ụsọ akpụkpọ ahụ cytoplasmic nke mkpụrụ ndụ ma mepụta ogige nnabata insulin. Site na mmezi nke biosynthesis cAMP (na sel na abụba) ma ọ bụ, na-abanye n'ime sel (akwara), insulin-receptor complex na-akpali usoro intracellular, gụnyere njikọ nke ọtụtụ enzymes isi (hexokinase, pyruvate kinase, glycogen synthetase, wdg). A na-eme ka mbelata ọbara glucose ọbara site n’ịbawanye na ebufe ọbara n’ime akwara, ịba ụba na nnabata nke anụ ahụ, mkpali nke lipogenesis, glycogenogenesis, njikọ protein, mbelata ọnụego glucose mepụtara site na imeju, wdg.

Mmetụta nke ọgwụ Mikstard® 30 NM Penfill® na-amalite n'ime ọkara otu elekere mgbe nchịkwa gasịrị, a na-egosipụta mmetụta kachasị n'ime awa 2-8, ebe ngụkọta oge nke ime ihe dị ka awa 24.

Usoro onunu ogwu na nhazi

A na-enyekarị insulin ọgwụ jikọtara ọnụ otu ugboro ma ọ bụ ugboro abụọ n'ụbọchị ma ọ bụrụ na achọrọ ngwakọta nke nsonaazụ ngwa ngwa na ogologo oge.

A na-ahọrọ ọ̀gwụ nke ọgwụ n’otu n’otu, na-eburu n'uche mkpa ndị ọrịa. Dị ka ọ dị, chọrọ insulin dị n'etiti 0.3 na 1 IU / kg / ụbọchị. Needchọrọ insulin kwa ụbọchị nwere ike ịdị elu karịa na ndị ọrịa nwere nguzogide insulin (dịka ọmụmaatụ, n'oge oge uto, yana na ndị ọrịa na-ebu oke ibu), na-agbadata na ndị ọrịa nwere ọgwụ insulin na-apụtakarị ihe.

Ọ bụrụ na ndị ọrịa na-arịa ọrịa shuga na-enweta njikwa glycemic kachasị mma, mgbe ahụ nsogbu nke ọrịa shuga na ha, dịka iwu, ga-apụta ma emesịa. N'akụkụ a, mmadụ kwesịrị ịgbalịsi ike ịkwalite njikwa metabolic, karịchaa, ha na-elezi anya nke ọma glucose dị n'ọbara.

A na-enye ọgwụ ahụ nkeji iri atọ tupu nri ma ọ bụ nri nwere carbohydrates.

Maka nhazi dị n'okpuru ala. N'ọnọdụ ọ bụla, ekwesịrị iji ọgwụ insulin kwụsịtụrụ. Mikstard® 30 NM Penfill® na-abụkarị nkebi subcutaneously na mpaghara nke mgbidi akụkụ ihu. Ọ bụrụ na nke a dabara adaba, mgbe ahụ injections nwekwara ike ịme n’apata ụkwụ, mpaghara gluteal ma ọ bụ mpaghara mpaghara akwara dị n’ubu (subcutaneously). Site na ntinye ọgwụ a na mpaghara mpaghara mgbidi afọ, a na-enweta mmịpụ ngwa ngwa karịa iwebata ya na mpaghara ndị ọzọ. Perrụpụta ntụtụ n’akpụkpọ ahụ na-ebelata ohere ịbanye n’olu. Okwesiri igbanwe ebe igba ogwu n’etiti mpaghara anatomical iji belata nsogbu nke lipodystrophy.

Ntuziaka maka iji Mikstard® 30 NM Penfill® ka enyee onye ọrịa ahụ.

Tupu ị Mikụ ọgwụ Mikstard® 30 NMPenfill®dị mkpa:

Lelee nkwakọ ngwaahịa iji jide n'aka na ahọrọ ụdị insulin dị mma.

Lelee katriiki mgbe niile, tinyere piston roba. Ọ bụrụ na achọpụtara ihe ọ bụla mebiri emebi, ma ọ bụ ọ bụrụ na achọtara n'etiti piston roba na akara teepu akara, akara ya enweghị ike iji ya. Maka ntuziaka ndị ọzọ, lee ntuziaka maka iji sistemụ insulin na-arụ ọrụ.

Jiri ogwu ojoo obula oge obula iji gbochie oria.

Wepu akwa akpụkpọ rọba na swab owu.

Ọgwụ Mikstard®30 nmPenfill®enweghị ike iji ya mee ihe ndị a:

Na insulin nfuli (nfuli)

Ọ bụrụ na katriiki ma ọ bụ ngwaọrụ itinye ya na-agbapụta, ma ọ bụ mebie ma ọ bụ mebisie, dị ka enwere ọghọm nke ịtọpụ insulin

Ọ bụrụ hypoglycemia amalite (shuga dị ala).

Ọ bụrụ na echeghị insulin n'ụzọ ziri ezi, ma ọ bụ kpụọ ya oyi

Ọ bụrụ na ọ chaghị ọcha otu ocha ma nwee urukpuru mgbe ịlaghachi azụ.

Tupu iji Mikstard® 30 NM Penfill®:

Lelee akara ahụ iji jide n'aka na ị na-eji ụdị insulin dị mma.

Wepu okpu nchebe.

Ọ bụ na Mikstard® 30 NM Penfill® bụ naanị makaonwe ya.

Etu ị ga-esi jiri ọgwụ ọjọọ Mikstard® 30 NM Penfill®

Ọgwụ Mikstard® 30 NM Penfill® bụ nke ezubere maka ọchịchị subcutaneous. Ya adịkwala mgbe ị ga-eji insulin emechi ma ọ bụ intramuscularly. Gbanwee oge ntanetị niile na mpaghara anwansi iji belata ihe mgbaze na ọnya na saịtị ahụ. Ebe kachasị mma maka injers bụ: aka, ikpere ma ọ bụ ubu.

Ntụziaka maka onye ọrịa ahụ ka esi etinye insulin

Tupu ị wụnye pọọdụ Penfill® dị na sistem insulin, bulie ma wedata katrijị ahụ opekata mpe ugboro iri wee gbadata n'etiti ọge na b, dị ka egosipụtara na ọnụ ọgụgụ a, nke mere na bọọlụ dị n'ime kadi ahụ na-aga site na nsọtụ nke katriki ahụ ruo na nke ọzọ opekata mpe 20. Tupu ntụtụ ọ bụla, ọ dịkarịa ala ụdị mmegharị ahụ 10 kwesịrị ịme. E kwesịrị imeghari ihe ndị a ruo mgbe mmiri mmiri na-acha ọcha na urukpuru. Gbanye ozugbo.