Nativa® (Nativa)

Aha ahia: Nativa
Aha International nonproprietary: Desmopressin
Aha kemịkal: 3-sulfanylpropanoyl-L-tyrosyl-L-phenylalanyl-L-lutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-D-arginylglycinamide cyclic 1-6 disulfide
Usoro onunu ogwu: ọgwụ

Nchikota kwa mbadamba
Ihe eji arụ ọrụ 0.1 mg 0.2 mg
Desmopressin Acetate 0.1 mg 0.2 mg
n'ihe banyere desmopressin 0.089 mg 0.178 mg
Ndị pụrụ iche
Lactose Monohydrate 10 mg 10 mg
Crospovidone XL 5 mg 5 mg
Magnesium stearate 2 mg 2 mg
Ludipress ruo 200 mg ruo 200 mg
na usoro nke akụrụngwa:
Lactose Monohydrate 170.1 mg 170.0 mg
Crospovidone 6.4 mg 6.4 mg
Povidone 6.4 mg 6.4 mg

Nkọwa
Usoro onunu ogwu 0.1 mg: ọcha mbadamba mbadamba ọcha nke nwere okpokoro na ihe ize ndụ n’otu akụkụ
Usoro onunu ogwu 0.2 mg: ọcha mbadamba mbadamba ọcha nke nwere okpokoro na ihe ize ndụ n’otu akụkụ

Otu na-ere ọgwụ: Ọrịa mamịrị mellitus ọgwụgwọ
Koodu ATX: H01VA02

Ngwongwo ogwu

Mlọ ọgwụ
Desmopressin bụ analog nke usoro eke alginine-vasopressin nke eke, na-enwe mmetụta antidiuretic. Enwetara Desmopressin n'ihi mgbanwe nke usoro nke vasopressin molecule - mbelata L-cysteine ​​na dochie nke 8-L-arginine maka 8-D-arginine.
Desmopressin na - abawanye ngwụcha nke epithelium nke ọdụm na - agbakọta nke nephron na mmiri ma na - abawanye njigide ya. Mgbanwe ndị a na-ejikọ ya na ikike iji ọgwụ mgbochi agbalite nke ukwuu na-eduga n'ịbelata mmetụta nke desmopressin n'arụ ahụ dị mma nke akwara ọbara na akụkụ ahụ dị iche iche ma e jiri ya tụnyere vasopressin, nke na-eduga na enweghị enweghị mmetụta spastic n'akụkụ. N'adịghị ka vasopressin, ọ na-eme ogologo oge ma ọ dịghị ebute mmụba ọbara mgbali (BP).
Ojiji nke desmopressin maka insipidus ọrịa shuga nke mkpụrụ ndụ ihe nketa na-eduga na mbelata oke mmamịrị ya na mmụba mmamịrị na mbelata oge plasma ọbara. Nke a na - eduga n'ịbelata oge mmesịrị ahụ yana Mbelata polyuria nocturnal.
Mmetụta antidiuretic kachasị mgbe ejiri ọnụ mee ya bụ n'ime awa anọ ruo awa asaa. Mmetụta antidiuretic mgbe ejiri ọnụ mee ihe na 0.1 - 0.2 mg - ruo awa 8, na nha 0.4 mg - ruo awa 12.
Mlọ ọgwụ
Egwu
Mgbe ejiri ya mee ihe, a na-enweta mkpokọta plasma kachasị (Cmax) n'ime awa 0.9. Iri nri otu oge nwere ike belata ogo nke absorption site na eriri afọ (GIT) na 40%.
Nkesa
Olu nke nkesa (Vd) bụ 0.2 - 0.3 l / n'arọ. Ntinye onu - 5%. Desmopressin adịghị agafe ihe mgbochi ọbara-ụbụrụ.
Ojiji
Ọ bụ ya mere akụrụ. Oge ndụ ọkara (T1 / 2) mgbe ejiri ọnụ kwuo ya bụ awa 1.5 ruo 2.5.

Ihe ngosi maka ojiji

• insipidus nke ọrịa shuga malitere
• Oge ihe dị na nwata na-eme ụmụaka gafere afọ ise
• Nocturnal polyuria n'ime ndị okenye (dịka usoro ọgwụgwọ Symptomatic).

Ihe mgbochi iji ya
Ọ bụrụ na ị nwere otu n’ime ọrịa ndị a, dị njikere ịkpọtụrụ dọkịta gị tupu ị takingụ ọgwụ ahụ.
• Hypersensitivity na desmopressin ma ọ bụ ihe ndị ọzọ nke ọgwụ ahụ
• polydipsia Habitual ma ọ bụ psychogenic
• nkụda obi na ọnọdụ ndị ọzọ chọrọ nchịkwa akwara
• Hyponatremia, gụnyere akụkọ banyere (ịta nke sodium ion na plasma ọbara n'okpuru 135 mmol / l)
• Udiri akwara na-agbake ma na-agbake (mwepụta creatinine n'okpuru 50 ml / min)
• mụaka na-erubeghị afọ anọ (maka ọgwụgwọ ọrịa shuga na-arịa ọrịa shuga) na afọ 5 (maka ọgwụgwọ nke isi ụtụtụ okirikiri)
• Ọrịa nke enweghị mmepụta homonụ antidiuretic ezughị ezu
• ụkọ Lactase, ekweghị na lactose, glucose-galactose malabsorption.

Jiri nlezianya

jiri ọgwụ maka ọdịda akụrụ, fibrosis eriri afọ, maka imebi ihe mmiri-electrolyte nguzogide, ihe ọghọm nke ịbawanye mgbali intracranial, n’oge ime.
Na oke ịkpachapụ anya jiri ọgwụ ahụ mee ihe na ndị ọrịa agadi (ihe karịrị afọ 65) n'ihi oke ihe ọghọm ndị ọ na-akpata (njigide mmiri, hyponatremia). Mgbe ị na-edepụta ọgwụgwọ na Nativa, ụbọchị 3 mgbe mmalite nke nchịkwa yana mmụba ọ bụla, a ga-ekpebi itinye uche nke sodium na plasma ọbara na nyochaa ọnọdụ onye ọrịa.

Jiri n’oge ime na n’oge a na-enye nwa ara

Dabere na data anyị maara, mgbe ị na-eji desmopressin n'ime ụmụ nwanyị dị ime nwere ọrịa insipidus, enweghị mmetụta ọ bụla na oge ime, na ọnọdụ ahụike nke nwanyị dị ime, nwa ebu n’afọ, na nwa amụrụ ọhụrụ.
Agbanyeghị, uru eburu n'uche nne ya na ihe nwere ike ibute nwa ebu n’afọ kwesịrị ijikọ.
Nnyocha e mere egosiwo na ọnụọgụ desmopressin na-abanye n'ime ahụ nwa amụrụ ọhụrụ nke mmiri ara nke nwanyị na-a doụ nnukwu desmopressin dị obere karịa nke ahụ nwere ike imetụta diuresis.

Usoro usoro, usoro nke ntinye, oge ọgwụgwọ

N'ime. A na-ahọrọ ọgwụ kachasị mma nke otu ọgwụ n'otu n'otu.
Ekwesịrị ị Theụ ọgwụ ahụ oge ụfọdụ mgbe erichara nri, ebe ọ bụ na iri nri nwere ike imetụta mmịpụta nke ọgwụ ahụ yana arụmọrụ ya.
Central insipidus ọrịa shuga: Usoro akwadoro ibido maka ụmụaka gbara afọ 4 na ndị okenye bụ 0.1 mg 1-3 ugboro kwa ụbọchị. Mgbe nke a gasịrị, a na-ahọrọ ọ̀tọ ahụ dabere na nzaghachi nye ọgwụgwọ. Dị ka ọ na-adịkarị, ọgwụ kwa ụbọchị sitere na 0.2 ruo 1.2 mg. Maka ọtụtụ ndị ọrịa, ezigbo mmezi bụ 0.1 - 0.2 mg 1-3 ugboro n'ụbọchị.
Primary ehihie na enuresis: Usoro akwadoro ịmalite maka ụmụaka gbara afọ 5 na ndị okenye bụ 0.2 mg n'abalị. Na enweghị mmetụta, enwere ike ịbawanye dose ahụ ruo 0.4 mg. Usoro a tụrụ aro maka ọgwụgwọ ga - aga n'ihu bụ ọnwa 3. A ga-eme mkpebi iji gaa n'ihu ọgwụgwọ dabere na data nyocha nke ụlọ ọgwụ a ga-ahụ mgbe ịkwụsịsịrị ọgwụ ahụ n'ime izu 1. Ọ dị mkpa iji nyochaa nrube isi na mmachi mmiri riri na mgbede.
Ndị okenye polyuria n'abalị: Usoro akwadoro ịmalite bụ 0.1 mg n'abalị. Ọ bụrụ na enweghị mmetụta n’ime ụbọchị asaa, ọnụọgụ ahụ na-abawanye ruo 0.2 mg ma mesịa ruo 0.4 mg yana mmụba na dose na ọnụọgụ nke na-akaghị karịa 1 oge kwa izu. Buru n'uche ihe egwu dị na njigide mmiri n’ahụ. Ọ bụrụ na mgbe izu 4 nke ọgwụgwọ na ntụgharị ọgwụ nke mmetụta a zuru oke na-adakarị ahụghị ọgwụ, na-akwadoghị ị theụ ọgwụ ahụ.

Ihe onyonyo 3D

Usoro onunu ogwu na nhazi

N'ime. A na-ahọrọ ọgwụ kachasị mma nke otu ọgwụ n'otu n'otu.

Ekwesịrị ị Theụ ọgwụ ahụ oge ụfọdụ mgbe erichara nri, ebe ọ bụ na iri nri nwere ike imetụta mmịpụta nke ọgwụ ahụ yana arụmọrụ ya.

Central insipidus ọrịa shuga: Usoro akwadoro ibido maka ụmụaka gbara afọ 4 na ndị okenye bụ 0.1 mg 1-3 ugboro kwa ụbọchị. Mgbe nke a gasịrị, a na-ahọrọ ọ̀tọ ahụ dabere na nzaghachi nye ọgwụgwọ. Dị ka ọ na-adịkarị, ọgwụ kwa ụbọchị sitere na 0.2 ruo 1.2 mg. Maka ọtụtụ ndị ọrịa, usoro nlekọta ahụ kachasị mma bụ 0.1-0.2 mg 1-3 ugboro n'ụbọchị.

Primary ehihie na enuresis: Usoro akwadoro ịmalite maka ụmụaka gbara afọ 5 na ndị okenye bụ 0.2 mg n'abalị. Na enweghị mmetụta, enwere ike ịbawanye dose ahụ ruo 0.4 mg. Usoro a tụrụ aro maka ọgwụgwọ ga - aga n'ihu bụ ọnwa 3. A ga-eme mkpebi iji gaa n'ihu ọgwụgwọ dabere na data ụlọ ọgwụ a ga-ahụ mgbe ịkwụsịsịrị ọgwụ ahụ ruo otu izu. Ọ dị mkpa iji nyochaa nrube isi na mmachi mmiri riri na mgbede.

Nocturnal polyuria n'ime ndị okenye: Usoro akwadoro ịmalite bụ 0.1 mg n'abalị. Ọ bụrụ na enweghị nsonaazụ n'ime ụbọchị 7, ọnụọgụ ahụ na-abawanye 0.2 mg ma mesịa ruo 0.4 mg (ugboro ugboro nke ịba ụba dose ahụ adịghị karịa 1 oge kwa izu). Buru n'uche ihe egwu dị na njigide mmiri n’ahụ. Ọ bụrụ na mgbe izu 4 nke ọgwụgwọ na ntụgharị ọgwụ nke mmetụta a zuru oke na-adakarị ahụghị ọgwụ, na-akwadoghị ị theụ ọgwụ ahụ.

Emeputa

Nativa LLC, Russia.

Adreesị iwu: 143402, Russia, Moscow Region, Krasnogorsk district, Krasnogorsk, st. Ọktoba 13.

Tẹ.: 8 (495) 502-16-43, 8 (495) 644-00-59.

e-mail: [email protected], www.nativa.pro

Adreesị saịtị ndị a na-emepụta: 143422, Ógbè Moscow, district Krasnogorsk, s. Petrovo-Dalnee, Russian Federation, 142279, Ógbè Moscow, ógbè Serpukhov, Obolensk, ụlọ 7–8 ma ọ bụ 143952, Ógbè Moscow, Balashikha, microdistrict. Dzerzhinsky, 40.

Ihe ngbanwe

- Hypersensitivity na desmopressin ma ọ bụ ihe ndị ọzọ nke ọgwụ ahụ,

- polydipsia nkịtị ma ọ bụ psychogenic,

- nkụda obi na ọnọdụ ndị ọzọ achọrọ maka nchịkwa akwara,

- hyponatremia, tinyere akụkọ banyere (ịta nke sodium ion na plasma ọbara n'okpuru 135 mmol / l),

- agafeghị oke nnukwu ọdịda akụrụngwa (mwepụta creatinine n'okpuru 50 ml / min),

- gbagoro afọ ụmụaka rue afọ anọ (maka ọgwụgwọ ọrịa shuga na-arịa ọrịa shuga) na afọ 5 (maka ọgwụgwọ nke isi ụtụtụ noctis),

- ọrịa nke ezughi oke homonụ antidiuretic,

- ụkọ Lactase, nnagide nri nke lactose, glucose-galactose malabsorption.

A na-eji nwa amaala anya ịkpachapụ anya gbasara akụrụ, fibrosis nke imebi ihe, mmiri elektrọnte anya mmiri, na ihe nwere ike ibute mgbali intracranial n'oge ịtụrụ ime.

Ekwesịrị ilebara anya nke ọma mgbe ị na-eji ọgwụ ahụ eme ihe na ndị ọrịa agadi (karịa afọ 65) n'ihi oke ihe egwu nke nsonaazụ (njigide mmiri, hyponatremia). Mgbe ị na-edepụta ọgwụgwọ na Nativa, ụbọchị 3 mgbe mmalite nke nchịkwa yana mmụba ọ bụla, a ga-ekpebi itinye uche nke sodium na plasma ọbara na nyochaa ọnọdụ onye ọrịa.

Mwepụta wepụtara ya na ihe mejupụtara

Ndị usoro Nativa bụ 0.1 / 0.2 mg mg mbadamba: gburugburu, ewepụghị, na-acha ọcha, nwere chamfer na ihe ize ndụ n'otu akụkụ (iberibe iri atọ na karama rọba, otu karama n'ime igbe kaadi).

Ngwakọta 1 mbadamba 0.1 / 0.2 mg:

• ihe na-arụ ọrụ: desmopressin acetate - 0.1 / 0.2 mg, na usoro nke desmopressin - 0.089 / 0.178 mg,
• ihe inyeaka: lactose monohydrate, crospovidone XL, magnesium stearate, ludipress (lactose monohydrate, crospovidone, povidone).

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime, a na-ahọrọ usoro ọgwụ ahụ n'otu n'otu.

Ekwesịrị ị Theụ ọgwụ ahụ oge ụfọdụ mgbe erichara nri, ebe ọ bụ na iri nri nwere ike imetụta mmịpụta nke ọgwụ ahụ yana arụmọrụ ya.

Central insipidus ọrịa shuga: usoro akwadoro ịmalite maka ụmụaka gbara afọ 4 na ndị okenye bụ 0.1 mg 1-3 ugboro n'ụbọchị. Mgbe nke a gasịrị, a na-ahọrọ ọ̀tọ ahụ dabere na nzaghachi nye ọgwụgwọ. Dị ka ọ na-adịkarị, ọgwụ kwa ụbọchị sitere na 0.2 ruo 1.2 mg. Maka ọtụtụ ndị ọrịa, usoro nlekọta ahụ kachasị mma bụ 0.1-0.2 mg 1-3 ugboro n'ụbọchị.

Primary nocturnal enuresis: usoro akwadoro ibido maka ụmụaka gbara afọ 5 na ndị okenye bụ 0.2 mg n'abalị. Na enweghị mmetụta, enwere ike ịbawanye dose ahụ ruo 0.4 mg. Usoro a tụrụ aro maka ọgwụgwọ ga - aga n'ihu bụ ọnwa 3. A ga-eme mkpebi iji gaa n'ihu ọgwụgwọ dabere na data nyocha nke ụlọ ọgwụ a ga-ahụ mgbe ịkwụsịsịrị ọgwụ ahụ n'ime izu 1. Ọ dị mkpa iji nyochaa nrube isi na mmachi mmiri riri na mgbede.

Ndị okenye polyuria n'abalị: Usoro akwadoro ịmalite bụ 0.1 mg n'abalị. Ọ bụrụ na enweghị mmetụta n’ime ụbọchị asaa, ọnụọgụ ahụ na-abawanye ruo 0.2 mg ma mesịa ruo 0.4 mg yana mmụba na dose na ọnụọgụ nke na-akaghị karịa 1 oge kwa izu. Buru n'uche ihe egwu dị na njigide mmiri n’ahụ.

Ọ bụrụ na mgbe izu 4 nke ọgwụgwọ na ntụgharị ọgwụ nke mmetụta a zuru oke na-adakarị ahụghị ọgwụ, na-akwadoghị ị theụ ọgwụ ahụ.

Mlọ ọgwụ

Desmopressin bụ analog nke usoro ihe omumu nke hormone arginine-vasopressin ma nwee mmetụta antidiuretic. Enwetara ya ka enwere mgbanwe n’usoro ihe omimi nke vasopressin.

Ihe nke Nativa bụ n'ihi ikike ya ịbawanye permeability nke epithelium nke akụkụ dị anya nke ọdụm na-emegharị nke nephron ka mmiri, na-abawanye njighachi ya. Enweghị mmetụta ndị dị na spastic n'ihi nsonaazụ akpọlata nkụ nke desmopressin na uru ahụ dị mma nke akwara ọbara na akụkụ ahụ dị n'ime ha ma e jiri ya tụnyere vasopressin. Ọgwụ a na-arụ ọrụ ogologo oge ma ọ naghị eme ka ọbara mgbali elu.

Mgbe a na-emeso desmopressin na ọrịa shuga nke insipidus nke sitere na isi, olu nke mmamịrị na-ebelata, osmolarity ya na-abawanye, na osmolarity nke plasma ọbara na-ebelata, nke na-eduga n'ịbelata ugboro ugboro nke urination na mbelata polyuria abalị. Nsonaazụ nke ọgwụ rutere ya oke mgbe awa 4-7 gachara wee rue awa 8-12, dabere na Nativa ewere ya.

Mlọ ọgwụ

Oke ruru ịta desmopressin erutela ma elekere 0.9. Nri na --ebe mmata nke ihe ahu site na 40%. Olu nke nkesa bụ 0.2-0.3 l / n'arọ. Ihe ahụ enweghị ike ịgafe ihe mgbochi ụbụrụ. Iwepu ọkara ndụ na-eme 1,5-2,5 awa. Akụrụ Desmopressin bụ akụrụ.

Ntụziaka maka iji Nativa: usoro na usoro onunu ogwu

Mpempe Nativa ka a na -ewere ọnụ tupu oge oriri. A na-ahọrọ ọ̀gwụ nke ọgwụ n’okwu nke ọ bụla.

• Central insipidus ọrịa shuga: usoro akwadoro nke mbụ bụ 0.1 mg, ugboro 1-3 kwa ụbọchị, mgbe ahụ, a na-abawanye dose ahụ dabere na mmeghachi omume nke onye ọrịa,
• isi nocturnal enuresis: usoro ọgwụgwọ akwadoro nke mbụ bụ 0.2-0.4 mg n'oge ụra. Ogologo oge ọgwụgwọ ahụ kwesịrị ihe dị ka ọnwa 3. A na-eme mkpebi na ohere nke ọgwụgwọ ọzọ na-adabere na data nyocha nke ụlọ ọgwụ nwetara n'ime ụbọchị 7 mgbe ịkwụsị ọgwụ ahụ. N'oge usoro ọgwụgwọ, a na-atụ aro Nativa ịgbaso usoro nchịkwa nke obere mmiri mgbede na mgbede,
• nocturnal polyuria n'ime ndị okenye: ọgwụ a na-atụ aro mbụ bụ 0.1 mg n'oge ụra. Na enweghị mmetụta mgbe ụbọchị asaa ị daysụ ọgwụ ahụ gasịrị, ọ ga-ekwe omume ịbawanye ọgwụ ahụ na 0.2, ma emesịa 0.4 mg / ụbọchị, yana otu izu. Ọ bụrụ na enweghị ọgwụgwọ ọgwụgwọ n'ime izu anọ 4 iwere Nativa, iji ya mee ihe na-adịghị mma.

Nsonaazụ

• sistemu ụjọ: isi ọwụwa, ọgbụgbọ, ihe na-enye ya nsogbu,
• Usoro nri: ọgbụgbọ, ọgbụgbọ, ọnụ na -akwụghị,
• sisitemu obi: akwara tachyarrhythmia, nwa oge,
• ahu nke anya: conjunctivitis,

Na mgbakwunye, ihe na-eme ụbụrụ akụkụ, yana mmụba n’arụ ahụ.

Nnweta Nativa na-enweghị mgbochi na ịnweta mmiri nwere ike ibute njigide mmiri na ahụ na hyponatremia.

Dodoụbiga ya ókè

Njuju nke Nativa nwere ike ibute njigide mmiri na hyponatremia site na itinye uche nke sodium ion na plasma ọbara n'okpuru 135 mmol / L.

Usoro ọgwụgwọ akwadoro: kwụsị ị takingụ ọgwụ ahụ ozugbo, kagbuo usoro mmachi mmiri nwere oke, ọ bụrụ na ọ dị mkpa, nye 0.9% ma ọ bụ hypertonic sodium chloride solution. N'ihe banyere ihe mgbaàmà nke njigide mmiri dị oke njọ (nkwusi, enweghị mwepụ), a na-edenye furosemide.

Ntụziaka pụrụ iche

Ọ dị mkpa amachibido ị fluidụ mmiri na elekere 1 tupu mgbe ọ bụla yana awa asatọ 8 gachara Nativa, iji zere ihe ọ bụla na-adịghị mma.

Dịka ntuziaka ahụ si dị, Nativa bụ contraindicated na ndị ọrịa n'ọnọdụ nke na-eduga njigide mmiri na ọgba aghara electrolyte.

Iji gbochie mmepe nke hyponatremia, a na-atụ aro ya ịchịkwa mkpokọta sodium na plasma ọbara.

N'ime ndị ọrịa nwere nnukwu urinary incontinence, nocturia, dysuria, ọrịa urinary tract, polydipsia, decompensated diabetes mellitus, yana ọ bụrụ na echere ma ọria mamiri ma ọ bụ prostate, ọ bụ ihe amamihe ịgwọ ma chọpụta ọrịa ndị a tupu ị were Nativa.

Ọ na-atụ aro ịkwụsị Nativa n'agbanyeghị ọrịa system, gastroenteritis na ahụ ọkụ.

Ime na lactation

Onweghi data banyere nsogbu ọjọọ nke desmopressin na-atụrụ ime, ọnọdụ nwa ebu n’afọ, na nwa amụrụ, na nne, mana tupu i jiri Nativa, uru ahụ / nzere kwesịrị ka ejiri nlezianya tụọ.

Ego ole ọgwụ a excụrụ na mmiri ara nne mgbe ị na-ewere Nativa na oke doses adịghị mkpa iji metụta diuresis nke nwa ahụ.

Mkparịta ụka ọgwụ ọjọọ

• ọgwụ na-ebelata ọbara: ihe ọghọm nke ịkwalite mmetụta ha,
• buformin, tetracycline, norepinephrine, nkwadebe nke lithium: belata mmetụta antidiuretic nke desmopressin,
• ọgwụ mgbochi-anaghị egbochi steroidal (NSAIDs): ihe ọghọm nke mmetụta ndị ọzọ na-abawanye;
• indomethacin: na - akwalite mmetụta nke desmopressin na-enweghị abawanye oge ọ na-eme,
• ọgwụ tricyclic antidepressants, nhọrọ serotonin reuptake inhibitors, narcotic analgesics, carbamazepine, chlorpromazine, lamotrigine, NSAIDs: nwere ike ịkwalite mmetụta antidiuretic nke Nativa, na-amụba ohere nke njigide mmiri na hyponatremia,
• loperamide na, ikekwe, ọgwụ ndị ọzọ na - agbada peristalsis: nwere ike ibute mmụba okpukpu atọ na mkpokọ desmopressin na plasma, na - amụba nnukwu ohere nke njigide mmiri na hyponatremia,
• dimethicone: enwere ike belata absorptionin desmopressin.

Analogs nke Nativa bụ Vasomirin, Desmopressin, Minirin, Nourem, Presineks.

Ọnụ ego Nativa na ụlọ ahịa ọgwụ

Ọnụ ego echere na Nativa bụ 1330 r maka ngwugwu nwere mbadamba 30 nke 0.1 mg.

Mmụta: Mahadum Ahụike Rostov State, ọpụrụiche "General Medicine".

A na - emejupụta ozi gbasara ọgwụ ahụ, enyere ya aka ka ọ nweta ihe ọ bụla, ọ naghị edochi ntuziaka gọọmentị. Medication medicationụ onwe gị ọgwụ dị ize ndụ nye ahụ ike!

Dabere na ọtụtụ ndị ọkà mmụta sayensị, usoro ihe ọmụmụ vitamin abaghị uru ụmụ mmadụ.

N’inye nlele mgbe niile n’elu akwa anụ ahụ, ohere i nwere ibute ọrịa anụ ahụ na-abawanye site na 60%.

Na UK, enwere iwu dịka onye dọkịta na-awa ahụ nwere ike jụ ịrụ onye ọrịa ahụ ma ọ heụọ anwụrụ ma ọ bụ buru oke ibu. Mmadụ kwesịrị ịhapụ omume ọjọọ, mgbe ahụ, ikekwe, ọgwụgwọ ịwa ahụ agaghị achọ ya.

Ọkpụkpụ mmadụ siri ike karịa okpukpu anọ.

Nwa nwoke onye Australia dị afọ 74, James Harrison ghọrọ onye na-enye ọbara n'ihe dị ka 1,000 ugboro. O nwere ụdị ọbara dị ụkọ, ọgwụ mgbochi nke enyere ụmụ amụrụ ọhụrụ aka na-arịa oke anaemia. N'ihi ya, onye Australia chebere ihe ruru ụmụaka nde abụọ.

Ọbara mmadụ "na-agabiga" n'ime arịa ndị nọ n'okpuru nrụgide dị ukwuu, ọ bụrụ na e mebiri iguzosi ike n'ezi ihe ya, ọ nwere ike gbaa 10 mita.

Ọ na-emebu ikuku ahụ na-eme ka ahụ nwee ikuku oxygen. Agbanyeghị, echiche a kagburu. Ndị sayensị achọpụtala na mgbagharị, mmadụ na-eme ka ụbụrụ dị jụụ ma na-eme ka arụmọrụ ya ka mma.

Ọ bụrụ na ị na-amụmụ ọnụ ọchị naanị ugboro abụọ n'ụbọchị, ịnwere ike belata ọbara mgbali ma belata ihe egwu nkụchi na ọnya afọ.

N'oge ịsụgharị, ahụ anyị na-akwụsị ịrụ ọrụ kpamkpam. Ọbụna obi na-akwụsị.

Dabere na nyocha nke WHO, mkparịta ụka kwa ụbọchị na ekwentị na-eme ka ohere nke ịmalite ụbụrụ dị 40% nwee ohere.

Ibu ahụ ụbụrụ mmadụ dị ihe dịka 2% nke mkpokọta ahụ, mana ọ na - eri ihe dị ka 20% nke oxygen na - abanye n'ọbara. Eziokwu a na-eme ka ụbụrụ mmadụ nwee ike ịkwụsi ike maka mmebi nke enweghị oxygen.

Akụrụ anyị nwere ike sachapụ lita atọ nke ọbara n'otu nkeji.

Imeju bụ akwara kacha anyị n’ahụ. Ogo ya di 1.5 n'arọ.

Ndị ọkà mmụta sayensị America mere nyocha na ụmụ oke wee kwubie na mmiri mmiri mmiri na-egbochi mmepe nke atherosclerosis nke arịa ọbara. Otu ìgwè na -a mụ mmiri dị ọcha, nke abụọ abụrụ mmiri ọ aụ juiceụ. N'ihi nke a, arịa nke ndị otu nke abụọ enwere nnukwu palesterol.

Ọtụtụ nde nje na-amụ, na-ebi ma na-anwụ na anyị gootu. Enwere ike ịhụ ha naanị na nnukwu ịdị elu, ma ọ bụrụ na ha gbakọtara ọnụ, ha ga-adaba na iko kọfị mgbe niile.

Oge izizi nke okooko osisi na-abịa na njedebe, mana ahịhịa ga-anọchi ahịhịa site na mbido June, nke ga-akpaghasị ndị na-arịa ya.

Omume ọgwụ

Nriva nọ n'ọrụ bụ desmopressin, analog nke ana - eme ka ihe anakpo hormone arginine-vasopressin nwee mmetụta antidiuretic. Desmopressin na - abawanye ngwụcha nke epithelium nke ọdụm na - agbakọta nke nephron na mmiri ma na - abawanye njigide ya. Mgbanwe ndị a na-ejikọ ya na ikike iji ọgwụ mgbochi agbalite nke ukwuu na-eduga n'ịbelata mmetụta nke desmopressin n'arụ ahụ dị mma nke akwara ọbara na akụkụ ahụ dị iche iche ma e jiri ya tụnyere vasopressin, nke na-eduga na enweghị enweghị mmetụta spastic n'akụkụ. N'adịghị ka vasopressin, ọ na-eme ogologo oge ma ọ dịghị ebute mmụba ọbara mgbali (BP).

Ojiji nke desmopressin maka insipidus ọrịa shuga nke mkpụrụ ndụ ihe nketa na-eduga na mbelata oke mmamịrị ya na mmụba mmamịrị na mbelata oge plasma ọbara. Nke a na - eduga n'ịbelata oge mmesịrị ahụ yana Mbelata polyuria nocturnal.

Mmetụta antidiuretic kachasị mgbe ejiri ọnụ mee ya na 4-7 awa. Mmetụta antidiuretic ahụ mgbe a na-eji ọnụ gị mee ihe na 0.1-0.2 mg dị ihe ruru awa 8, na nha 0.4 mg - ruo awa 12.