Ọgwụ Glemaz: ntuziaka maka ojiji > Ọgwụgwọ na mgbochi

Mpempe usoro onodu ogwu - mbadamba: akuku anọ, nke dị larịị, na-acha akwụkwọ ndụ akwụkwọ ndụ na agba, jiri akara atọ yiri ibe ha etinyere obosara nke mbadamba ya na akụkụ abụọ ma kewaa ya n'ime akụkụ anọ nha (5 ma ọ bụ 10 na blisters, na mkpọ nke kaadi 3 ma ọ bụ 6 blisters )

Ngwakọta ọrụ: glimepiride, na mbadamba 1 - 4 mg.

Ihe ndi ozo: microcrystalline cellulose, magnesium stearate, cellulose, croscarmellose sodium, acha anụnụ anụnụ na-acha anụnụ anụnụ, ntutu quinoline.

Ihe ngbanwe

Ọrịa shuga 1dị 1
Leukopenia
Nnukwu akwara gbasara akwara (gụnyere contraindicated maka ndị ọrịa na hemodialysis),
Ọrịa imeju siri ike,
Ọrịa mamịrị precca na coma, mamịrị ketoacidosis,
Ọnọdụ tinyere malabsorption nri na mmepe nke hypoglycemia (gụnyere ọrịa na-efe efe),
N’agbata afọ 18
Ime na lactation
Hypersensitivity na mmiri nke ọgwụ ma ọ bụ ihe ndị ọzọ na-eme ka sulfonylurea na ọgwụ sulfonamide.

Ekwesịrị iji Glemaz mee ihe na nlezianya na ọnọdụ chọrọ nnyefe onye ọrịa na ọgwụgwọ insulin, dị ka malabsorption nri na ọgwụ na eriri afọ (gụnyere gastres paresis na mgbochi eriri afọ), nnukwu ịwa ahụ ịwa ahụ, nnukwu mmerụ ahụ, nnukwu mmerụ ahụ.

Usoro onunu ogwu na nhazi

Glemaz ji ọnụ kwuo okwu. Ekwesịrị ị doseụ ya kwa ụbọchị n’otu ọgwụ tupu ma ọ bụ n’oge nri ụtụtụ ma ọ bụ nri mbụ. A ga-elo mbadamba ndị ahụ n'ejighi ata, jiri mmiri mmiri hichaa ya (ihe dị ka iko ½). Mgbe ị takingụ ọgwụ ahụ, a naghị atụ aro ya ka ọ malite nri.

A na-ekpebi oge a ga -echekwa usoro ọgwụgwọ na nrụzi n’otu n’otu dabere na nsonaazụ nke mkpebi siri ike nke ịba uru glucose na ọbara.

Na mmalite ọgwụgwọ, a na-enyekarị 1 mg nke glimepiride (1 /₄ mbadamba) 1 oge kwa ụbọchị. Ọ bụrụ na ọ ga - ekwe omume ị nweta nsonaazụ kachasị mma, a ka ga - ewere ọgwụ ahụ na otu ọgwụ (dika usoro mmezi).

Na enweghị nchịkwa glycemic, a na-eji nwayọọ nwayọọ na-abawanye kwa ụbọchị, na-eleba anya na ịba ụba nke glucose n'ọbara: kwa izu 1-2, nke mbụ ruo 2 mg, mgbe ahụ ruo 3 mg, mgbe ahụ ruo 4 mg (ọgwụ karịrị 4 mg dị irè naanị n'ọnọdụ ndịiche ) Ogo ị na-anabata kwa ụbọchị bụ 8 mg.

Ọ bụ dọkịta ga-ekpebi oge na ugboro ole ị drugụ ọgwụ ahụ dabere na ndụ onye ọrịa. Ọgwụgwọ ahụ dị ogologo, glucose ọbara na-achịkwa.

Jiri na metformin mee ihe

Ọ bụrụ na enweghị ike ịnweta njikwa glycemic na ndị ọrịa na-ewere metformin, enwere ike ịdere ọgwụ njikọta na Glemaz. N'okwu a, a na-edozi dose nke metformin n'otu ọkwa ahụ, a na-edozikwa glimepiride na obere opekempe, emesịa ọ na-eji nwayọọ nwayọọ ruo ogo kachasị elu kwa ụbọchị (dabere na glucose n'ọbara). A na-eme ọgwụgwọ njikọta n'okpuru nlekọta nlekọta ahụike.

Jiri yana insulin

Ọ bụrụ na ndị ọrịa na-anata Glemaz na ọnụọgụ kachasị dị ka otu ọgwụ ma ọ bụ jikọtara ya na oke nke metformin enweghị ike ịnweta njikwa glycemic, enwere ike ịde ọgwụ ọgwụgwọ insulin. N'ọnọdụ a, a na-ahapụ ọgwụ ikpeazụ glimepiride edeghị, a na-atụkwa insulin na obere opekata mpe, ọ bụrụ na ọ dị mkpa, jiri nwayọ mee ka ọ dị n’okpuru nchịkwa nke glucose na ọbara. A na-eme ọgwụgwọ agbakọtara n'okpuru nlekọta ahụike dị nso.

Nyefee onye ọrịa na Glemaz site na ọgwụ ọgwụ hypoglycemic ọzọ

Mgbe ị na-ebufe onye ọrịa site na ọgwụ nje hypoglycemic ọzọ, ọgwụ mbu nke glimepiride kwesịrị ịbụ 1 mg, ọ bụrụgodị na a drugụrụ ọgwụ ọzọ na oke kachasị. Ọ bụrụ na ọ dị mkpa, n'ọdịniihu, ịba ụba nke Glemaz ka ọ na-erukwu elu site na ntuziaka ndị akọwapụtara n’elu ma na-eburu na ịdị irè, dose na oge nke usoro ọgwụ hypoglycemic etinyere. N'ọnọdụ ụfọdụ, ọkachasị mgbe ị na - eji hypoglycemic na - elekọta mmadụ na ndụ ogologo ndụ, ọ nwere ike ịdị mkpa ịkwụsị ọgwụ ruo nwa oge (maka ọtụtụ ụbọchị) iji zere mmetụ ahụ na - eme ka ọ bụrụ ọrịa hypoglycemia.

Nyefee onye ọrịa site na insulin gaa glimepiride

N'ọnọdụ ndị pụrụ iche, mgbe ị na-eme ọgwụ insulin na ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa shuga, ebe ha na-akwụ ụgwọ maka ọrịa ahụ na ọrụ echekwara nke mkpụrụ ndụ reat-pancreatic, a ga-eji ọgwụ glimepiride dochie insulin. Ceptionmata Glemaz na-amalite site na opekempe nke 1 mg, a na-ebufe nnyefe ahụ n'okpuru nlekọta ahụike dị nso.

Nsonaazụ

Metabolism: mmeghachi omume hypoglycemic nke na-erukwa obere oge ka ị takingụsịrị ọgwụ ahụ (ha nwere ike inwe ụdị siri ike na N'ezie, ha enweghị ike ịkwụsị ya ngwa ngwa mgbe niile),
Usoro nri: afọ mgbu, mmetụta nke ibu ma ọ bụ ahụ erughị ala na epigastrium, ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, jaundice, cholestasis, mụbara ọrụ nke transpeases hepatic, ọrịa ịba ọcha n'anya (ruo ọrịa imeju).
Hemopoietic sistem: aplastic or hemolytic anaemia, erythrocytopenia, leukopenia, granulocytopenia, pancytopenia, agranulocytosis, thrombocytopenia (modulas to hete),
Ahụ nke ọhụụ: ọtụtụ mgbe na mmalite nke ọgwụgwọ - nkwarụ anya adịghị ala,
Mmeghachi omume nfụkasị: urticaria, ọnya ọnya, itching (ọ na-adịkarị nwayọọ, mana enwere ike ịbawanye mma, tinyere mkpirisi iku ume na iweda ọbara mgbali elu, na-eduga n'ọrịa anaphylactic), nfụkasị na-egbu egbu na sulfonamides na ụdị sulfonylureas ndị ọzọ ma ọ bụ ihe ndị yiri ya, vasculitis nfụkasị,
Ndị ọzọ: n'ọnọdụ ụfọdụ - hyponatremia, asthenia, photosensitivity, isi ọwụwa, mbubreyo akpụkpọ porphria.

Ntụziaka pụrụ iche

Ekwesịrị ịgwọta Glemaz kpam kpam na ndụmọdụ dọkịta. Njehie nke ịnabata usoro (dịka ọmụmaatụ, ịwụfe oge ọzọ) agaghị enwe ike iwepụ ya site na usoro ọzọ dị elu. Onye ọrịa ahụ kwesịrị ka ya na dọkịta kwụọ ụzọ ihe ndị aga-eme ma ọ bụrụ na ụdị njehie ndị ahụ ma ọ bụ n'ọnọdụ mgbe ọgwụ ọzọ ga-agaghị ekwe omume n'oge a kara aka. Onye ọrịa ahụ kwesịrị ịgwa dọkịta ozugbo ozugbo ma ọ aụọla nnukwu ọgwụ.

Mmepe nke hypoglycemia mgbe ewere Glemaz kwa ụbọchị nke 1 mg pụtara na enwere ike ịchịkwa glycemia naanị site na nri.

Ozugbo emere ihe nkwụghachi ụgwọ maka ụdị shuga nke 2, uche insulin na-abawanye, yabụ enwere ike ịchọ mbelata glimepiride. Iji gbochie mmepe nke hypoglycemia, ịkwesịrị ibelata dose ahụ ruo nwa oge ma ọ bụ kagbuo Glemaz kpamkpam. E kwesịrị ime mgbanwe ntụgharị uche na mgbanwe nha ahụ onye ọrịa, ụzọ ndụ ya, ma ọ bụ ihe ndị ọzọ nwere ike iduga mmepe nke hypo- or hyperglycemia.

Kachasị nlezianya nyochaa onye ọrịa dị mkpa na izu mbụ nke ọgwụgwọ, n'ihi Ọ bụ n'oge a ka ihe ize ndụ nke ịmalite ịrịa hypoglycemia na-abawanye. Ọnọdụ yiri nke ahụ na-apụta mgbe ị na-ahapụ nri ma ọ bụ na-eri nri mgbe niile.

Okwesiri iburu n’uche na enwere ike imeghari oria hypoglycemia ma obu ghara idi na ndi agadi, ndi oria nwere oria akwara na ndi ọrịa na anata beta-blockers, reserpine, clonidine, guanethidine. Ọgwụ hypoglycemia fọrọ nke nta ka ọ bụrụ na enwere ike ịkwụsị ngwa ngwa site na nri nke carbohydrates ozugbo (shuga ma ọ bụ glucose, dịka ọmụmaatụ, n'ụdị mpempe shuga, tii dị ụtọ ma ọ bụ mmiri mkpụrụ osisi). Maka nke a, a na-atụ aro ka ndị ọrịa na-enwekarị glucose 20 g glu (4 iberibe shuga a nụchara anụcha). Ndị na-atọ ụtọ ụtọ na ọgwụgwọ nke hypoglycemia anaghị arụ ọrụ.

Oge ọgwụgwọ niile ya na Glemaz, ọ dị mkpa ileba anya mgbe niile gbasara mkpokọta glucose na ọbara, ọkwa nke glycosylated haemoglobin, ọrụ imeju, onyoonyo nke ọbara mgbago (ọkachasị ọnụ ọgụgụ platelet na sel ọbara ọcha).

N'ọnọdụ nrụgide (dịka ọmụmaatụ, yana ọrịa na-efe efe na ahụ ọkụ, ịwa ahụ ma ọ bụ trauma), ị nwere ike ịchọ onye ọrịa ruo oge ụfọdụ na insulin.

N'oge ọgwụgwọ, ekwesịrị ịkpachara anya mgbe ị na-eme ihe egwu nwere ike ime, mmejuputa iwu nke chọrọ nhazigharị mmeghachi omume na ịbawanye ụba (gụnyere mgbe ị na-anya ụgbọala).

Mkparịta ụka ọgwụ ọjọọ

Site n'otu oge iji Glemaz na ọgwụ ndị ọzọ, mgbanwe omume ya ga - ekwe omume - iwusi ike ma ọ bụ na - adịghị ike. Yabụ, ịnwe ọgwụ ọ bụla ọzọ ka dọkịta gị ga-ekwenye.

Ngkwusi ike nke hypoglycemic nke Glemaz na, n'ihi nke a, mmepe nke hypoglycemia nwere ike ime ka nkwonkwo na ọgwụ ndị na-esote: insulin, metformin, ọgwụ ọgwụ hypoglycemic ndị ọzọ, angiotensin na-agbanwe enzyme inhibitors, steroid anabolic na nwoke mmekọahụ homonụ, monoamine oxidase inhibitors acid), ndị na - egbochi ọgwụ - ọgwụ quinolone, tetracyclines, sympatholytics (gụnyere guanethidine), ụfọdụ ndị na - arụ ọrụ ogologo oge, wdg. coumarin nkwekọrịta, fibrates, allopurinol, trofosfamide, fenfluramine, ifosfamide, fluoxetine, miconazole, cyclophosphamide, chloramphenicol, oxyphenbutazone, tritokvalin, azapropazone, fluconazole, sulfinpyrazone, phenylbutazone, pentoxifylline (ndinọ parenterally na elu doses).

Imebi ike nke hypoglycemic nke Glemaz na, n'ihi nke a, mmụba na mkpokọta nke glucose n'ọbara, nwere ike ime ka njikwa nkwonkwo na ọgwụ ndị na-esote: glucocorticosteroids, thiazide diuretics, laxatives (ya na iji ogologo oge), estrogens na progestogens, barbiturates, epinephrine na ndị ọzọ na-ekwu, salim, na ndị ọzọ nicotinic acid (na nnukwu usoro) na usoro ya, glucagon, diazoxide, acetazolamide, ọgwụ phenothiazine, gụnyere chlorpromazine, rifampicin, phenytoin, nnu nke lithium, homonụ thyroid.

Reserpine, clonidine, histamine H mgbochi₂ndị na-anabata ya nwere ike mebie ma belata ike hypoglycemic nke glimepiride. N'okpuru mmetụta nke ọgwụ ndị a na guanethidine, enweghị adịghị ike ma ọ bụ izu ezu nke akara ngosipụta hypoglycemia ga-ekwe omume.

Glimepiride nwere ike ịkụda ma ọ bụ kwalite mmetụta nke usoro coumarin.

N'ihe banyere otu oge iji ọgwụ eme ihe na-egbochi ụmị ọkpụkpụ, ihe ọghọm nke imepụta myelosuppression na-abawanye.

Otu mmanya ma ọ bụ nke na-adịghị ala ala nke ịveraụ mmanya na-aba n'anya nwere ike ịkwalite ma mee ka ike gwụ hypoglycemic mmetụta nke Glemaz.

Ihe analogues nke ogwu Glemaz bu: Amaryl, Glimepiride, Glimepiride Canon, diamerid.

Ntụziaka maka iji Glemaz (usoro na usoro onunu ogwu)

A na-ewere ọnụ Glemaz ọnụ na otu ọgwụ ozugbo tupu ma ọ bụ n'oge nri ụtụtụ na-egbu mmụọ, ma ọ bụ nri nri mbụ. Were mbadamba ihe nile, a ,ụla, drinkụọ ọtụtụ mmiri (ihe dị ka iko 0,5). A na-eme usoro ahụ iche iche dabere na nyocha nke nlele glucose ọbara ugboro ugboro.

Usoro izizi: 1 mg 1 oge kwa ụbọchị. Mgbe ị na-enweta nsonaazụ ọgwụgwọ kachasị mma, a na-atụ aro ị thisụ ọgwụ a dịka ọgwụ mmezi.

Ọ bụrụ na enweghị nchịkwa glycemic, mmụba nwayọ na-abawanye kwa ụbọchị ga-ekwe omume (site na ị na-enyochakarị glucose ọbara n'ọtụtụ izu 1 ruo 2) ruo 2 mg, 3 mg ma ọ bụ 4 mg kwa ụbọchị. A pụrụ ịụ doses karịa 4 mg kwa ụbọchị naanị n'ọnọdụ ndịiche.

Ikike dị ukwuu a na-atụ aro kwa ụbọchị: 8 mg.

Agụmakwụkwọ ọgwụgwọ: ogologo oge, n'okpuru nchịkwa nke glucose ọbara.

Jiri na metformin mee ihe

Enweghị njikwa glycemic na ndị ọrịa na-ewere metformin, ọgwụgwọ concomitant na glimepiride ga-ekwe omume.

Ọ bụ ezie na ị na-echekwa usoro nke metformin na otu ọkwa, ọgwụgwọ glimepiride na-amalite site na obere opekempe, mgbe nke ahụ, dose ahụ na-eji nwayọọ nwayọọ na-abawanye dabere na glucose chọrọ n'ọbara, ruo n'ọtụtụ kachasị elu kwa ụbọchị.

Ekwesịrị ịmalite ọgwụgwọ njikọta n'okpuru nlekọta ahụike.

Jiri yana insulin

N'ọnọdụ ụfọdụ, monotherapy na Glemaz, yana njikọ yana metformin, anaghị enye nsonaazụ achọrọ: enweghị ike ịnweta njikwa glycemic. N'ọnọdụ dị otú ahụ, ngwakọta glimepiride na insulin ga-ekwe omume. N'okwu a, ọgwụ ikpeazụ glimepiride nke enyere onye ọrịa ahụ agbanwebeghị, ọgwụgwọ insulin na-amalite site na obere opekata mpe, na enwere ike ịbawanye nwayọ na-esote ya mgbe ọ na-achịkwa nchịkwa glucose ọbara.

Ijikọtara ọgwụgwọ chọrọ nlekọta nlekọta ahụike.

Nyefee site na ọgwụ ọgwụ hypoglycemic ọzọ gaa glimepiride

Usoro ọgwụgwọ kwa ụbọchị: 1 mg (ọbụlagodi na a na-ebugharị onye ọrịa ahụ na glimepiride na oke ọgwụ ọgwụ hypoglycemic ọzọ).

Mmụba ọ bụla na dose Glemaz kwesịrị ka eme ya na nkebi, dabere na ọgwụgwọ ahụ, usoro na oge nke ihe nnọchi anya hypoglycemic ji.

N'ọnọdụ ụfọdụ, ọkachasị mgbe ị na - eji ọgwụ hypoglycemic mee ogologo ndụ ọkara, ọ nwere ike ịdị mkpa ka ịhapụ nwa oge (n'ime ụbọchị ole na ole) ịkwụsị ọgwụ iji zere mmetụta mmụba na-abawanye ohere ịba ụba hypoglycemia.

Ntughari site na insulin rue glimepiride

N'ọnọdụ ndị pụrụ iche, mgbe ị na-eme ọgwụ insulin na ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa shuga, ebe ha na-akwụ ụgwọ maka ọrịa ahụ ma na-ejigide ọrụ nzuzo nke mkpụrụ ndụ reat-pancreatic, enwere ike iji glimepiride dochie insulin.

A na-eme ntụgharị ahụ n'okpuru nlekọta nke dọkịta.

Usoro izizi: 1 mg kwa ụbọchị.

Nsonaazụ

Ojiji nke ogwu ahu nwere ike ibute nsogbu ndi a:

Metabolism: obere oge ị takingụ ọgwụ ahụ, ọdịdị nke mmeghachi omume hypoglycemic ga-ekwe omume, nke nwere ike ịnwe usoro na ụdị siri ike ma ọ nweghị ike ịkwụsị ya ngwa ngwa.
Okwu banyere ọhụụ: n'oge ọgwụgwọ (ọkachasị na mbido ya), enwere ike ịhụ nsogbu anya gafere oge metụtara mgbanwe nke glucose ọbara.
Sistem hematopoietic: leukopenia, aplastic ma ọ bụ hemolytic anaemia, ọkara na thrombocytopenia, pancytopenia, agranulocytosis, erythrocytopenia na granulocytopenia.
Usoro nri: ọgụ nke ọgbụgbọ, ọgbụgbọ, mgbu nke afọ, ahụ erughị ala ma ọ bụ oke ibu na epigastrium, afọ ọsịsa, ọrụ mụbara enzymes imeju, jaundice, cholestasis, ịba ọcha n'anya (gụnyere mmepe nke imeju imeju).
Ngosiputa ekpughere: aru aru, itching, urticaria nwere ike ime. Dị ka ọ na-adị, mmeghachi omume ndị ahụ na-adị nwayọọ, mana enwere ike ịga n'ihu mgbe ụfọdụ, tinyere ume mkpụmkpụ (ruo na mmepe nke ụfụ anaphylactic), mbelata ọbara mgbali elu. Mmeghachi omume nfụkasị na-esite na usoro ndị ọzọ nke sulfonylurea, sulfonamides ma ọ bụ sulfonamides kwere omume, yana mmepe nke vasculitis nfụkasị.
Ndị ọzọ: n'ọnọdụ ụfọdụ, mmepe nke mbubreyo nke ure mbubreyo nke afọ, fotoensitivity, hyponatremia, asthenia, na isi ọwụwa.

Omume ọgwụ

Glemaz bụ ọgwụ hypoglycemic nke ọgwụ. Ngwakọta dị ukwuu nke ọgwụ ahụ bụ glimepiride, nke na-akpali secretion na ntọhapụ nke insulin site na mkpụrụ ndụ pancreatic (-akpata (ọ na-eme ka ọ bụrụ ihe dị mma), na-eme ka amamịghe anụ ahụ dị (akwara na abụba) rụọ ọrụ insulin nke ya (nsonaazụ nke pancreatic).

N’ime otu ingestion, akụrụ na-ewepụ ihe dịka 60% nke ọgwụ were, 40% fọdụrụ n’ime gafere eriri afọ. Achọpụtaghị ihe dị n’ime mmamịrị. Ndi_1/2 n'ọbara plasma nke ọgwụ dị n'ọbara nke kwekọrọ na usoro usoro onunu ogwu, bụ elekere ise ruo nke asatọ._1/2 mgbe ị theụsịrị ọgwụ ahụ na nnukwu doses.

Dodoụbiga ya ókè

Dika nyocha nke Glemaz, mgbe ị sesụsịrị ọgwụ ọ highụ highụ ukwuu, hypoglycemia nwere ike ịmalite, na-adịgide awa 12-72, nke enwere ike ikwugharị ọzọ mgbe mweghachi nke ọkwa glucose ọbara nkịtị.

A na-egosipụta hypoglycemia site na: ịsụsọ ịba ụba, tachycardia, nchekasị, ahụ ike, mmụba ọbara na agụụ, obi mgbu, isi ọwụwa, arrhythmia, dizzness, iro ụra, ọgbụgbọ, ọgbụgbọ, nchekasị, enweghị ọmịiko, oke iwe, ịtalata mgbada, ọgba aghara, , paresis, ịma jijiji, nkwarụ, inwe mmetụta uche, coma.

Iji na-emeso ịdoụbiga mmanya ókè, ọ dị mkpa iji mee ka onye ọrịa ghara ịna-agbọ agbọ. Ekwenyekwa nnukwu mmanya na sodium picosulfate na unyi na-arụ ọrụ.

Ọ bụrụ na ejiri ọgwụ dị elu mee ihe, mgbe ahụ, a na-eme lavage gastric, mgbe ahụ, a ga-ewebata sodium picosulfate na unyi arụ ọrụ, mgbe emesịrị iwepụta dextrose. Ọgwụgwọ na-abụ Symptomatic.

Mmekọrịta na ọgwụ ndị ọzọ

N'iji oge nke ọgwụ iji:

Metformin, insulin, ndị ọzọ ọnụ na hypoglycemic mmadụ, allopurinol, Ace inhibitors, nwoke mmekọahụ homonụ, anabolic Steroid, chloramphenicol, cyclophosphamide, coumarin nkwekọrịta, ifosfamide, trofosfamide, fibrates, fenfluramine, sympatholytic, fluoxetine, Mao inhibitors, pentoxifylline, miconazole, probenecid, phenylbutazone , oxygenphenbutazone, azapropazone, salicylates, ihe ndị quinolone, tetracyclines, sulfinpyrazone, fluconazole, tritokvalin - na-apụta na ike nke hypoglycemic mmetụta,
Acetazolamide, diazoxide, barbiturates, saluretics, glucocorticosteroids, thiazide diuretics, epinephrine, glucagon, nicotinic acid na ihe ndị dị na ya, ọgwụ phenothiazine, estrogens na progestogens, homonụ thyroid - mmetụta hypoglycemic ya,
Histamine H Blockers₂-ịkara, clonidine, mmanya - nwere ike imebi ma welie mmetụta hypoglycemic,
Site na ogwu nke na egbochi oria hematopoiesis, onodu myelosuppression abawanye.