Ofloxin 200 (Ofloxin® 200)

Nkọwa nke metụtara 21.04.2016

• Aha Latin: Ofloxacin
• Koodu ATX: J01MA01
• Arụ Ọrụ: Ofloxacin (Ofloxacin)
• Emeputa: Pharmstandard-Leksredstva, Synthesis Kurgan Joint-Stock Company of Medicines na Ngwa OJSC, talọ ọgwụ Valenta, Skopinsky Pharmaceutical Plant, MAKIZ-PHARMA, Obolenskoye - ụlọ ọrụ ọgwụ, Rafarma ZAO, Ozon LLC, Krasfarma Russia, Biosynthesis OPC

• Na 1 Erere - 200 na 400 mg ofloxacin. Nnukwu ọka, MCC, talc, magnesium stearate, polyvinylpyrrolidoneAerosil dị ka ihe inyeaka.
• Na 100 ml usọbọ - 200 mg nke ihe eji arụ ọrụ. Sodium chloride na mmiri, dị ka ihe inyeaka.
• Na 1 g otite - 0.3 g nke ihe eji arụ ọrụ. Nipagin, mmanụ jelii, nke dị ka ihe dị ka ihe inyeaka.

Mlọ ọgwụ

Ofloxacin ọ bụ ọgwụ nje ma ọ bụ na ọ bụghị? Nke a abụghị ọgwụ nje, na onye na-ahụ maka ọgwụ nje site na otu ahụ floroinated quinolonesnke ahụ abụghị otu ihe ahụ. Ihe dị iche site na ọgwụ mgbochi na usoro na mbido ya. Fluoroquinolones enweghi usoro analog, ọdịdị ọgwụ nje bụ ihe esi pụta ụwa.

Mmetụta nke nje ahụ na-egbochi njikọ nke DNA gyrase, nke gụnyere imebi njikọ DNA na nkewa sel, mgbanwe na mgbidi sel, cytoplasm na ọnwụ sel. Ntinye nke a fluorine atọm n’ime mointinine nke quinoline gbanwere ụdị ihe dị na antibacterial - ọ gbasawanyere nke ọma ma tinyekwa microorganisms na-eguzogide ọgwụ nje na ụdị na-emepụta beta-lactamases.

Gram-positive na gram-na-adịghị mma microorganisms nwere mmetụta na ọgwụ ahụ, yana chlamydia, ureaplasmas, mycoplasmas, igbonerella. Na-egbochi uto nke mycobacteria ụkwara nta. Ọ naghị emetụta ya Treponema pallidum. Microflora iguzogide ji nwayọọ nwayọọ. Mmetụta ọgwụ nje na - esote bụ ihe njiri.

Mlọ ọgwụ

Abshapụ izu oke mgbe ingestion dị mma. Bioavailability 96%. Akụkụ dị ntakịrị nke ọgwụ ahụ nwere ihe jikọrọ ya na protein. A na-ekpebi itinye uche kachasị mgbe elekere 1. A na-ekesa ya nke ọma na anụ ahụ, akwara na mmiri, na-abanye n’ime sel. A na-ahụta ihe dị mkpa na azịza, sputum, nkuume, myocardium, mucosa eriri afọ, ọkpụkpụ, anụ ahụ prostate, akụkụ ahụ nke nwanyi, anụ ahụ na eriri.

Ọ na-abanye nke ọma n’ime mgbochi niile yana mmiri mmiri akụkụ eriri akpa. Ihe dịka 5% nke dose bụ biotransformed imeju. Nkera ọkara bụ awa 6-7. Site na nchịkwa ugboro ugboro, egosighi cumu. Ọ bụ ya mere akụrụ (80-90% nke dose) yana obere akụkụ ya na bile. Na ọdịda akụrụngwa, T1 / 2 na-abawanye. Site na ọrịa imeju, ịmịpụ pụrụ ịdị nwayọ.

Ihe ngosi maka ojiji

• ọla kọpa, oyi baa,
• ENT ọrịa nke akụkụ (pharyngitis, sinusitis, otitis media, laryngitis),
• akụrụ na urinary tract ọrịa (pyelonephritis, urethritis, ahu otutu),
• ọrịa akpụkpọ, anụ ahụ dị nro, ọkpụkpụ,
• endometritis, salpingitis, parametritis, oophoritis, cervicitis, colpitis, prostatitis, epididymitis, orchitis,
• ọgbụgba, chlamydia,
• ọnya isi ịba ọcha n'anya, conjunctivitis, keratitis, bali, ọnya chlamydial nke anya, mgbochi nke ibute ọrịa mgbe mmerụ ahụ na arụ ọrụ (maka ude).

Ihe ngbanwe

• afọ ruo afọ 18
• hypersensitivity
• tụụrụ ime,
• inye ara,
• Akwụkwụ na-adọ ma ọ bụ ịdị njikere nke ukwuu mgbe emerụsịrị ụbụrụ ụbụrụ, ihe mberede ụbụrụ na ọrịa ndị ọzọ nke sistemụ akwara ozi,
• ekwuputala na mbibi akwara na-aga n'ihu mgbe nchịkwa gasịrị fluoroquinolones,
• nsogbu neuropathy akụkụ,
• anabataghi lactose,
• afọ rue otu afọ (maka ude).

Ejiri nlezianya nye ọrịa nke ụbụrụ. myasthenia gravisimebi oke nke imeju na akụrụ, ịba ọcha n'anya, obi obara, ọrịa shuga, infarction myocardialparoxysmal ventricular tachycardia, bradycardiana nká.

Nsonaazụ

Mmeghachi azụ na-esokarị:

Mmeghachi ike na-adịghị ahụkebe:

• mmụba ọrụ transaminase, jalestice cholestatic,
• ịba ọcha n'anya, ọbara ọgbụgba, pseudomembranous colitis,
• isi ọwụwa, anya ntughari,
• nchekasị, oke iwe,
• ehighi uraoké nrọ
• ụjọ, phobias,
• ịda mba,
• ịma jijijiogwe
• paresthesia nke akansogbu neuropathy ebe,
• conjunctivitis,
• tinnitus ntị anụrị,
• imebi nghọta nke agba, ọhụhụ abụọ
• uto nsogbu
• tendonitis, myalgia, arthralgiamgbu na aka
• mgbaji anụ ahụ
• palpitations arrhythmia ventricular, ọbara mgbali elu,
• akọrọ ụkwara, mkpụkpu ume, bronchospasm,
• petechiae,
• leukopenia, anaemia, thrombocytopenia,
• ọrụ ezughi oke, dysuria, njigide urinary,
• ọnya, itching nke anụ ahụ, urticaria,
• eriri afọ dysbiosis.

Dodoụbiga ya ókè

Eweputara anya ntughari, igba azu, iro ụra, ndaba, uche ya, mmasi, vomiting. Ọgwụgwọ mejupụtara lavage gastric, diureis na ọgwụgwọ Symptomatic. Ọ na-eji ọrịa nkwarụ egwu Diazepam.

Mmekorita

Mgbe atọrọ Suṣirefata, antacids na nkwadebe nwere alumini, zinc, magnesium ma obu iron, ibelata mmamiri ofloxacin. Enwere mmụba na arụmọrụ anticoagulants na-apụtachaghị ìhè mgbe ị takenụ ọgwụ a. Usoro coagulation chọrọ.

Ihe ọghọm nke mmetụta neurotoxic na ọrụ nkwenye na-abawanye site na nchịkwa oge nke NSAIDs, usoro ọmụmụ. nitroimidazole na methylxanthines.

Mgbe etinyere ya na Theophylline nhwepu ya na-ebelata ma iwepu ọkara ndụ na-abawanye.

Ojiji nke ihe ndị na - eme hypoglycemic nwere ike ibute ọnọdụ hypoglycemic.

Mgbe etinyere ya na Okirikiri ọnụọgụ dị n'ọbara ya na ọkara ndụ.

Ikekwe mbelata nke ọbara mgbali elu mgbe etinyere ya mgbochi ego na ọgwụ antihypertensive.

Mgbe etinyere ya na glucocorticosteroids enwere ihe ọghọm nke ịdọ aka na ntị.

Enwere ike ịgbatị oge nke oge QT na iji ọgwụ antipsychotic, ọgwụ antiarrhythmic, ọgwụ tricyclic antioxide, macrolides, ihe ndị na-egosi imidazole, astemizole, terfenadine, ebastina.

Ojiji nke carbon anhydrase inhibitors, sodium bicarbonate na citrates, nke na-edozuga mmamiri, na-abawanye ohere nke kristalia na nephrotoxicity.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime, n'ime / n'ime. A họrọ doses nke Ofloxin 200 n'otu oge dabere na ọnọdụ, ogo nke ọrịa ahụ, mmetụta nke microorganisms, yana ọnọdụ izugbe nke onye ọrịa na ọrụ nke imeju na akụrụ.

Na / na ntinye okwu ga-amalite n ’otu ọgwụ nke 200 mg, nke a na-eleda anya, jiri nwayọ karịa nkeji 30-60. Mgbe ọnọdụ onye ọrịa ahụ dị mma, a na-ebuga ya na nchịkwa ọnụ nke ọgwụ ahụ n'otu ọgwụ kwa ụbọchị.

N'ime / n'ime: ọrịa urinary tract - 100 mg 1-2 ugboro kwa ụbọchị, akụrụ na ọrịa anụ ahụ - site na 100 mg ugboro abụọ kwa ụbọchị ruo 200 mg ugboro abụọ kwa ụbọchị, ọrịa akụkụ iku ume yana akụkụ akụkụ ENT, ọrịa anụahụ. na anụ ahụ dị nro, ọrịa nke ọkpụkpụ na nkwonkwo, ọrịa nke eriri afọ, ọnya nje, ọrịa septikiti - 200 mg ugboro abụọ kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, mee ka ọgwụ ahụ gaa na mg mg 400 ugboro 2 n'ụbọchị.

Maka mgbochi nke ibute ọrịa na ndị ọrịa nwere ọnụọgụ ọgwụ mgbochi - 400-600 mg / ụbọchị.

Ọ bụrụ na ọ dị mkpa, iv drip - 200 mg na 5% dextrose solution. Ogologo oge nke infusion 30 nkeji. Jiri naanị edozi edozi edozi.

N'ime: ndị okenye - 200-800 mg / ụbọchị, usoro ọgwụgwọ - ụbọchị 7-10, ugboro ole ojiji - ugboro abụọ kwa ụbọchị. Enwere ike ịkọ ọgwụ ruru ihe dịka 400 mg / ụbọchị na 1 dose, ọkacha mma n'ụtụtụ. Ya na gonorrhea - mg mg otu ugboro.

N'ime ndị ọrịa nwere ọrụ mgbazinye nsogbu (ya na CC 50-20 ml / min), otu mmachi kwesịrị ịbụ 50% nke nkezi iji otu ugboro nke nchịkwa ugboro abụọ kwa ụbọchị ma ọ bụ na-enye otu ọgwụ zuru ezu otu oge kwa ụbọchị. Na CC na-erughị 20 ml / min, otu ọgwụ bụ 200 mg, mgbe ahụ 100 mg / ụbọchị kwa ụbọchị.

Na hemodialysis na peritoneal dialysis, 100 mg kwa awa 24. Oke kachasị kwa ụbọchị maka ọdịda imeju bụ 400 mg / ụbọchị.

Mbadamba mbadamba, na mmiri, tupu ma ọ bụ n'oge nri. A na-ekpebi oge ọgwụgwọ ga-enwe site na nghọta nke pathogen na foto ụlọ ọgwụ, a ga-aga n'ihu maka ọgwụgwọ ọ dịkarịa ala ụbọchị 3 ka mgbama nke mgbaàmà ọrịa ahụ na ịdị ọcha zuru oke nke ahụ. Na usoro salmonella, usoro ọgwụgwọ bụ ụbọchị 7-8, yana ọrịa ndị na - enweghị nsogbu nke obere akpa urinary, usoro ọgwụgwọ bụ ụbọchị 3-5.

Omume ọgwụ

Onye na - ahụ maka ọgwụ nje na - efe efe nke ukwuu site na otu nke fluoroquinolones na - arụ ọrụ na nje nje enzyme DNA, nke na - enye njikwa mkpuchi, wdg. nkwụsi ike nke nje nje DNA (ibibi ụdọ DNA na-eduga n'ọnwụ ha). Ọ nwere mmetụta nje na-akpata.

Na-arụ ọrụ megide microorganisms na-emepụta beta-lactamases na mycobacteria na-eto ngwa ngwa. Nnukwu mmetụta: Staphylococcus aureus, epiramidis Staphylococcus, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter, Klebsiella spp. (gụnyere Klebsiella ka oyi baa), Enterobacter spp., Hafnia, Proteus spp. (gụnyere Proteus mirabilis, Proteus vulgaris - indole nke oma na indole na-adịghị mma), Salmonella spp., Shigella spp. (Gụnyere Shigella sonnei), Yersinia enterocolitica, Campylobacter jejuni, Aeromonas hydrophila, Plesiomonas aeruginosa, Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydia spp., Legionella spp., Serratia spp., Providencia spp., Haemophilus ducreyi, Bordetella parapertussis, Bordetella pertussis, Moraxella catarrhalis, ọria propionibacterium, Brucella spp.

Uche dị iche iche banyere ọgwụ ahụ nwere: Enterococcus faecalis, pyogenes Streptococcus, pneumoniae na ụmụ agbọghọ, Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter, Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacteriumium tubuli monocytogenes, Gardnerella vaginalis.

N'ọtụtụ oge, enweghi obi abụọ: Nocardia asteroides, nje nje anaerobic (dịka ọmụmaatụ Bacteroides spp., Peptococcus spp., Peptostreptococcus spp., Eubacter spp., Fusobacterium spp., Clostridium difficile). Odighi uru maka treponema pallidum.

Ntụziaka pụrụ iche

Ọ bụghị ọgwụ ịhọrọ maka oyi oyi nke pneumococci kpatara. Egosiputaghi ya maka ọgwụgwọ nke oria ojoo.

A naghị atụ aro ka ejiri karịa ọnwa 2, kpughere ya maka ìhè anyanwụ, ụzarị ọkụ ụzarị UV (oriọna Mercury-quartz, solarium).

Ọ bụrụ na nsonaazụ ndị sitere na sistemụ akwara etiti, mmeghachi ahụ nfụkasị, pịudomembranous colitis, iwepụ ọgwụ dị mkpa. Site na paiudomembranous colitis, colonoscopically na / ma ọ bụ n'akụkọ ihe mere eme, egosipụtara nchịkwa ọnụ nke vancomycin na metronidazole.

Ugbo ala ugboro ugboro nwere ike ibute ọgbụgba akwara (ọkachasị akwara Achilles), ọkachasị ndị agadi. N'ihe banyere ihe nrịba ama nke akwara, ọ dị mkpa ịkwụsị ọgwụgwọ ozugbo, kwụsịlata akwara Achilles ma kpọtụrụ onye na-arịa orthopedist.

N'oge ọgwụgwọ, ekwesighi ị beụ mmiri ethanol.

Mgbe ị na-a theụ ọgwụ ahụ, a naghị atụ aro ụmụ nwanyị ka ha jiri tampons ọcha n'ihi oke egwu nke ahịhịa.

Na-emegide usoro ọgwụgwọ, ịbawanye njọ nke myasthenia gravis, mmụba nke ọgụ porphyria na ndị ọrịa nwere ike.

Nwere ike ibute nsonaazụ ụgha na nje bacteria na-achọpụta ọrịa ụkwara nta (na-egbochi mpụta ụkwara nta Mycobacterium).

N'ime ndị ọrịa nwere ọria imeju ma ọ bụ ọrụ akụrụ, nyocha nke plasma nke ofloxacin dị mkpa. Na oke akụrụ na oke ịba ọcha n'anya, ohere nke mmetụta mmụba na-abawanye (a na -ebelata nhazi ndozi).

N'ime ụmụaka, a na-eji ya naanị n'ihe banyere ndụ egwu, na-eburu n'uche ebubo arụmọrụ ụlọ ọgwụ yana ọghọm nke nsonaazụ ọ bụla, mgbe ọ gaghị ekwe omume iji ọgwụ ndị ọzọ na-egbu egbu. Nkezi onwa kwa ubochi n’onodu a bu 7.5 mg / kg, ihe kachasi bu 15 mg / kg.

N'oge ọgwụgwọ nke Ofloxin 200, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike ịdị ize ndụ chọrọ mmụba nlebara anya na ọsọ nke mmeghachi omume psychomotor.

Mpempe usoro onunu ogwu

Mbadamba ihe nkiri 200 mg.

Otu mbadamba ihe

ike - ofloxacin 200.00 mg

ndị na-ebu ụzọ: lactose monohydrate 95.20 mg, ọka ọka 47.60 mg, povidone 25 - 12.00 mg, crospovidone 20.00 mg, poloxamer 0.20 mg, magnesium stearate 8.00 mg, talc 4.00 mg

ihe nkiri ihe nkiri: hypromellose 2910/5 - 9.42 mg, polyethylene glycol 6000 - 0,53 mg, talc 0.70 mg, titanium dioxide (E171) - 2.35 mg

Mbadamba ụrọ ndị gbara okirikiri, biconvex, ihe nkiri nwere, nke na-acha ọcha ma ọ bụ nke fọrọ nke nta ka ọ bụrụ nke na-acha ọcha, na-enwe ihe ize ndụ maka ịgbarị n’akụkụ otu mbadamba na akara "200" n’akụkụ nke ọzọ.

Ngwongwo ogwu

Mwepu ya mgbe ịbatara dị ngwa ngwa zuru oke. A na-enweta ntinye uche kachasị na plasma ọbara n'ime awa 1-3 ka otu ọgwụ were kwa 200 mg. Oge iwepu ọkara ndụ bụ awa 4-6 (n'agbanyeghị agbanyeghị).

Na ọdịda akụrụngwa, e kwesịrị ibelata dose ahụ.

O nweghi mmekọrịta dị mma na nri ahụghị.

Mlọ ọgwụ

Ofloxacin bụ ọgwụ antibacterial nke ndị otu quinolone, nke nwere mmetụta nje na-akpata. Mainzọ kachasị arụmọrụ bụ mgbochi nke nje enzyme nke nje bacteria. Ihe nhicha nke enwetara na DNA na - etinye aka na nnomi DNA, ntụgharị, ndozi, na ntughari. Inhibido ihe enzyme nke DNA na-eduga n'inweta ma mebie DNA nje na-akpata ma na-akpata ọnwụ nke mkpụrụ ndụ nje.

Antibacterial ụdịdị dị iche iche nke microorganisms ka ofloxacin.

Microorganisms nwere mmetụta nke ofloxacin: Staphylococcusaureus(gụnyere methicillin na-eguzogide ọgwụ)Staphylococci),Staphylococcusepidermidis,Neisseriaumu,Esherichiacoli,Citrobmanacter,Klebsiella,Enterobacter,Hafnia,Ihe nchebe(gụnyere indole-nke oma na nke adịghị mma),,Haemophilusinfluenza,Chlamydie,Legionella,Ugbaala.

Microorganisms nwere ezi uche dị na toloxacin: Ike,Serratiamarcescens,PseudomonasaeruginosanaMycoplasmas.

Microorganisms na-eguzogide (enweghi mmetụta) na ofloxacin: ọmụmaatụ Bacteroidesumu,Eubacteriumumu,Fusobacteriumumu,Peptococci,Peptostreptococci.

Usoro onunu ogwu na nhazi

N'ime, nkeji 30-60 tupu nri, were obere mmiri mmiri sachaa ya, maka ndi okenye - 200-400 mg ugboro abụọ n'ụbọchị, ma ọ bụ 400-800 mg 1 oge kwa ụbọchị, N'ezie - 7-10 ụbọchị. Thebọchị kwa ụbọchị bụ 200-800 mg. N'ihe banyere ọrụ imeju na - arụ ọrụ - ọ bụghị karịa 400 mg, dose ahụ na-adabere na Cl creatinine: ya na Cl 20-50 ml / min, ọgwụ mbụ bụ 200 mg, mgbe ahụ 100 mg kwa awa 24, na Cl erughị 20 ml / min nke mbụ bụ 200 mg, mgbe ahụ 100 mg kwa awa 48

Maka ụmụaka (n'ihe mberede), ngụkọta ụbọchị kwa ụbọchị bụ 7.5 mg / n'arọ ahụ (ọ karịghị 15 mg / n'arọ).

Nchedo nchekwa

Ekwesịrị ịtụle maka mbelata nke mmeghachi omume (ejiri nlezianya debe ya mgbe ọ na-anya ụgbọala). N'ime ụmụaka, ojiji ga-ekwe omume naanị n'ọnọdụ dị oke njọ (mgbe mmetụta ọgwụgwọ na-atụ anya gafere karịa ihe egwu nke nsonaazụ).

Ekwesịrị itinye ọgwụ maka atherosclerosis nke arịa ụbụrụ, ihe ọghọm ụbụrụ, ọrụ akwara nwere nsogbu.

Ndị na-ahụ maka ọgwụ

Ndị na-ahụ maka ọgwụ mgbochi maka iji usoro. Fluoroquinolones. PBX koodu J01M A01.

• Ọrịa azụ na elu nke ukwu
• akụkụ okuku ume na-efe efe
• ọrịa akpụkpọ ahụ na anụ ahụ dị nro,
• ọgbụgba na-agbadighi agbatị nke urethra na ọwara cervical,
• ọrịa ọnya na-abụghị gonococcal na cervicitis.

Mmeghachi omume ọjọọ

N’akụkụ nke anụ ahụ na ọnya subcutaneous: itching, ọnya, urticaria, blisters, flushing, hyperhidrosis, pustular rashes, erythema multiforme, vaskụla purpura, Stevens-Johnson syndrome, Lyell’s syndrome, nnukwu site na exanthematous pustulosis, photoensitivity, hypersensitivity ịkpụcha akpụkpọ ahụ ma ọ bụ ikpochapụ mbọ.

N’akụkụ nke usoro ahụ ji alụso ọrịa ọgụ: mmeghachi omume hypersensitivity, gụnyere mmeghachi omume anaphylactic / anaphylactoid, angioedema (gụnyere ọrịrị nke ire, ogwooro, pharynx, ọria / ọkụ nke ihu), ure anaphylactic / anaphylactoid. Mmeghachi omume anaphylactic / anaphylactoid nwere ike ịmalite ozugbo mgbe nchịkwa nke ofloxacin, gụnyere ihe mgbaàmà anaphylaxis, tachycardia, ahụ ọkụ, mkpụmkpụ ume, ujo, angioedema, vasculitis, nke n'ọnọdụ ndị pụrụ iche nwere ike ibute necrosis, eosinophilia. N'okwu a, ekwesịrị ịkwụsị ọgwụ nke ọgwụ ahụ ma ịmalite ọgwụgwọ ọzọ.

N'akụkụ nke usoro akwara obi: tachycardia, hypotension art-igba mkpumkpu, ndọkata (ma ọ bụrụ na ọrịa hypotension siri ike, ọgwụgwọ kwesịrị ịkwụsị) ventricular arrhythmia, fibrillation flutter-ventricular (nke a hụrụ tumadi na ndị ọrịa nwere ihe ọghọm maka ịgbatị oge QT) na ECG, ịgbatị oge QT. .

Site na sistemụ ụjọ: isi ọwụwa, ọgbụgbọ, nkụda mmụọ, nsogbu ịrahụ ụra, ehighị ụra nke ọma, ụra, nchekasị, nchekasị, nkwarụ, ọgba aghara, nsụhọ, ụra abalị, na - agbadata mmeghachi omume mgbali, mgbali intracranial, paresthesia, sensor ma ọ bụ sensorimotor neuropathy, shoor na ihe omimi ndi ozo, njikwa ike nke aru (adighi nma, ihe anapughi ekwesi), ihe omume uche, echiche igbu onwe / omume, ihe iju anya.

Site na ngwe nri: anorexia, ọgbụgbọ, vomiting, gastralgia, mgbu nke afọ ma ọ bụ ihe mgbu, afọ ọsịsa, enterocolitis, mgbe ụfọdụ hemorrhagic enterocolitis, flatulence dysbiosis, pseudomembranous colitis.

Usoro hepatobiliary: ubara ọkwa nke enzymes imeju na ọkwa bilirubin, cholestatic jaundice, ịba ọcha n'anya.

Site na sistemụ urinary: ọdịda akụrụ ya na mmụba nke urea, nnukwu akụrụngwa nnukwu ọrịa akụrụngwa, nnukwu ịba uru nephritis.

Site na usoro akwara: akwara, ihe nhịahụ, myalgia, ọrịa ogbu na nkwonkwo, ụsọ anụ ahụ, mgbatị anụ ahụ (gụnyere akwara Achilles), nke nwere ike ibilite awa iri anọ na asatọ mgbe ebido iji ofloxacin ma nwee ike ịbụ ọgbụgba, rhabdomyolysis na / ma ọ bụ myopathy ike adighi ike.

N'akụkụ ọbara na sistem lymphatic: neutropenia, leukopenia, anaemia, hemolytic anaemia, eosinophilia, thrombocytopenia, pancytopenia agranulocytosis, mgbochi nke ụmị ọkpụkpụ.

Site na akwara anụ ahụ: mgbakasị anya, vertigo, ọhụhụ ụzọ, ụtọ, isi, fotophobia, tinnitus, mfu ịnụ ntị.

Site na usoro iku ume: ụkwara, nasopharyngitis, mkpụmkpụ ume, bronchospasm, ahu na-efe efe, oke ume.

Ọrịa metabolism: hypoglycemia ma ọ bụ hyperglycemia (n'ime ndị ọrịa nwere ọrịa mellitus).

Ọrịa: ọrịa fungal, candidiasis, iguzogide microorganisms pathogenic.

Ndị ọzọ: mwakpo kpụ ọkụ n'ọnụ nke porphyria na ndị ọrịa na-arịa ọrịa porphyria, ọrịa, ike ọgwụgwụ.

Jiri n’oge ime ma ọ bụ n’ịra

Ofloxacin bụ contraindicated n'ime ụmụ nwanyị n'oge afọ ime na lactation n'ihi enweghị ahụmị ọgwụ ọ theụ. Ofrexacin excretion n'ime mmiri ara ara.

Ọ bụrụ na ọ dị mkpa iji ọgwụ ahụ, a ga-akwụsị inye ya ara maka oge ọgwụgwọ.

A na - enye ogwu ogwu n’etiti umuaka na umuaka.

Njirimara ngwa

Tupu ịmalite ọgwụgwọ, ọ dị mkpa iji duzie ule: ọdịbendị na microflora na mkpebi siri ike nke ofloxacin.

Mgbe ị na-eji ofloxacin, ọ dị mkpa iji nwee mmiri zuru oke. N'ime ndị ọrịa nwere akụrụ akwara na arụ ọrụ ọria, a ga-eji ọgwụ kpachara anya ma kpachara anya nyocha nke imeju na akụrụ. Maka ndị ọrịa nwere nsogbu gbasara akụrụngwa nsogbu, o kwesịrị idozigharị ọgwụ ofloxacin nke enyere ya, nye ya oge ewepụrụ.

Ọ bụrụ na arụ ọrụ imeju adịghị arụ ọrụ, a na-eji ofloxacin eme ihe nke ọma n'ihi ohere ọrụ ọrụ imeju na-arụ. Maka fluoroquinolones, akọọla banyere ọrịa ịba ọcha n'anya zuru oke, nwere ike ibute imeju (tupu ọnwụ). Kwụsị ọgwụgwọ ma gakwuru dọkịta ma ọ bụrụ na ihe ịrịba ama na ihe mgbaàmà nke ọrịa imeju dị ka anorexia, jaundice, mmamịrị gbara ọchịchịrị, itching, na afo nwere mmetụta.

Ọrịa kpatara Clostridium difficile. Ọrịa shuga, karịsịa siri ike, na-adịgide, ma ọ bụ gwakọtara ya na ọbara, n'oge ma ọ bụ mgbe ọgwụgwọ nke ofloxacin nwere ike ịbụ mgbaàmà pseudomembranous colitis. Ọ bụrụ na-enyo enyo pịudomembranous colitis, ekwesịrị ịwepụ ofloxacin ozugbo ma kwesịrị ịmalite usoro ọgwụgwọ ọrịa Symptomatic n'echeghị ya (dịka ọmụmaatụ, vancomycin, teicoplanin ma ọ bụ metronidazole). N'ọnọdụ a, ọgwụ ndị na-egbochi motali eriri afọ.

A kọwo na hypersensitivity na mmeghachi omume nfụkasị na fluoroquinolones mgbe ojiji mbụ. Mmeghachi omume anaphylactic na mmeghachi omume anaphylactoid nwere ike ịbanye n'oké ihe egwu, bụ ihe egwu ndụ, ọbụlagodi mgbe ojiji nke mbụ. N'okwu a, a ga-akwụsị ikwesịrị nnabata ma ọgwụgwọ kwesịrị ekwesị amalite.

Ndị ọrịa na - a ofụ ọgwụ ofloxacin kwesịrị izere ikpughe anwụ na ụzarị UV (akwa ndina) n'ihi ohere enwere ike. Ọ bụrụ na mmeghachi omume fotoensitivity (dịka ọmụmaatụ, nke yiri anwụ ọkụ anwụ anwụ) mere, a ga-akwụsị ịhapụ ọgwụ nke ofloxacin.

A kọwo na ọnọdụ nke sensory ma ọ bụ sensọimotor peripheral neuropathy na ndị ọrịa na-ewere fluoroquinolones, gụnyere ofloxacin. Site na mmepe nke neuropathy, ekwesịrị ịkwụsị nke ofloxacin.

N'ọnọdụ ụkwara ume ọkụ dị egwu, a ga-akwụsị ị useụ ọgwụ.

Oge etiti QT na-agbatị. Mgbe ị na-ewere fluoroquinolones, a kọtụrụla ikpe ikpe gbasara ịgbatị oge nke QT. Ekwesịrị ịkpachara anya mgbe ị na-ewere fluoroquinolones, gụnyere ofloxacin, n'ime ndị ọrịa nwere ihe ndị a maara nke ọma maka ịgbatị oge QT, ndị ọrịa agadi, nwere ahaghị nrịba ahụ (hypokalemia, hypomagnesemia), congenital ma ọ bụ enwetara ogologo oge nke oge QT, ọrịa obi (nkụda obi, nkụda mmụọ myocardial, bradycardia).

Ọrịa Tendonitis. N'ọnọdụ ndị a na-adịghị ahụkebe, ọgwụgwọ na quinolones nwere ike ibute tendonitis, nke nwere ike ibute mgbapu nke akwara, gụnyere akwara Achilles. Ndị ọrịa oge ọkọchị kachasị nwee ike ịrịa ọrịa tendonitis. A na - eme ka ihe na - eme ka mkpụrụ akụ aka ike site na iji ọgwụ corticosteroids. Ọ bụrụ na echee na tendinitis ma ọ bụ ihe mgbaàmà mbụ nke ihe mgbu ma ọ bụ mbufụt pụtara, a ga-akwụsị ọgwụgwọ nke toloxacin ozugbo yana usoro kwesịrị ekwesị (dịka ọmụmaatụ, iji hụ na enweghi ike ịkwụsị ọrịa).

A ga-akpachara ndị ọrịa nwere nsogbu akwara etiti akụkụ ahụ, yana ọrịa akwara arteriosclerosis, nwere ọrịa uche ma ọ bụ akụkọ banyere ofloxacin.

N'ime ndị ọrịa nwere ọrịa shuga, ofloxacin nwere ike ibute mmetụta nke hypoglycemic nke insulin, ọgwụ mgbochi antidiabetic (gụnyere glibenclamide). Ndị ọrịa a kwesịrị ịchịkwa shuga ọbara ha.

Site na ọgwụgwọ ogologo oge ma ọ bụ ugboro ugboro, ọrịa ndị nwere ohere na uto nke microorganisms na-eguzogide ọgwụ ga-ekwe omume. Site na mmepe nke ọrịa nke abụọ, a ga-emerịrị ihe kwesịrị ekwesị.

N'oge ọgwụgwọ nke ofloxacin, dị ka ọgwụ ọjọọ ndị ọzọ nke otu a, iguzogide ụfọdụ ụdị nke Pseudomonas aeruginosa nwere ike ịmalite ngwa ngwa.

Ofloxacin abụghị ọgwụ ịhọrọ maka ọgwụgwọ nke oyi baa n'ahụ nke pneumococci ma ọ bụ mycoplasmas, ma ọ bụ ọrịa tonsillitis nke β-hemolytic streptococci kpatara.

N'oge ọgwụgwọ ekwesịghị ị shouldụ ihe ọholicụ alcoụ na-aba n'anya.

Eji nlezianya nye ndị ọrịa nwere akụkọ banyere myasthenia gravis.

Ndị ọrịa na-a antụ ọgwụ vitamin K kwesịrị inyocha coagulation ọbara mgbe ha na-ewere ofloxacin na vitamin K antagonists (warfarin) site na ihe ọghọm nke ọbara coagulation (prothrombin oge) na / ma ọ bụ ọbara ọgbụgba.

Ọgwụ a nwere lactose, yabụ, ndị ọrịa nwere ụdị ọrịa hectate na-enweghị ụyọkọ galactose, ụkọ lactase ma ọ bụ ọrịa glucose-galactose malabsorption syndrome ekwesịghị iji ọgwụ ahụ.

Ikike iji metụta ọnụego mmeghachi omume mgbe ị na-anya ụgbọala ma ọ bụ usoro ndị ọzọ

N'ọnọdụ mmeghachi omume na-adịghị mma site na sistemụ akwara, akụkụ nke ọhụụ, a na-atụ aro izere ịnya ụgbọ ala ma ọ bụ jiri usoro.

Mmekọrịta na ọgwụ ndị ọzọ na ụdị mmekọrịta ndị ọzọ.

Site na oge nchịkwa ofloxacin na ndị na - egbochi ọgwụ mgbochi, mbelata ọbara mgbali elu ga-ekwe omume. N'ọnọdụ ndị dị otú a, ma ọ bụ ọ bụrụ na ejiri ofloxacin mee ihe maka izizi ya na mgbochi ọrịa, ọ dị mkpa iji nyochaa ọrụ nke sistem obi.

A machibidoro ya iji ofloxacin n'otu oge yana ọgwụ ndị na-agbatị oge etiti QT (ọgwụ klas antiarrhythmic klas - quinine, procainamide na klas III - amiodarone, sotalol, tricyclic antidepressants, macrolides).

Ojiji nke ofloxacin na ọgwụ mgbochi na - abụghị steroidal na - egbochi mkpali (gụnyere usoro nke propionic acid), usoro nitroimidazole na methylxanthines na - ebute nsogbu nke nephrotoxic, belata mbido ihe ọdịdọ, nke nwere ike ibute mmepe mmepe nke ihe ọdịdọ.

Nlekọta nke ofloxacin n’otu oge na nnukwu onunu ogwu yana ọgwụ nke tubular na-ewepụta nwere ike ibute ndọta Plasma n’ihi mbelata nke arụpụta ha.

Ebe ọ bụ na n'otu oge iji ọtụtụ quinolones, gụnyere ofloxacin, na-egbochi ọrụ enzymatic nke cytochrome P450, ọgwụ nke ofloxacin nwere ọgwụ nke usoro a (cyclosporine, theophylline, methylxanthine, kafiin, warfarin) gbatịpụrụ ndụ ọgwụ ndị a.

Site na nhazi nke ofloxacin na vitamin K antagonists, ọ dị mkpa iji nyochaa usoro coagulation ọbara oge niile.

Ojiji nke ọgwụ ahụ n’otu mgbe na antacids nke nwere calcium, magnesium ma ọ bụ nke aluminom, yana ihe na-aganị, ya na iron ma ọ bụ ferric, nke nwere protein nke nwere zinc, na-ebelata nnabata nke ofloxacin. Ya mere, etiti dị n'etiti ị theseụ ọgwụ ndị a kwesịrị ịbụ ma ọ dịkarịa ala elekere 2:00.

Site na ojiji nke ofloxacin na onodu hypoglycemic na-elekọta mmadụ na insulin, hypoglycemia ma ọ bụ hyperglycemia ga-ekwe omume. Ya mere, odi nkpa ileba anya nha maka ikwughachi ha. Iji otu oge eji glibenclamide, mmụba nke ọkwa glibenclamide na plasma ọbara ga-ekwe omume.

Mgbe ejiri ọgwụ na-egbochi mmamịrị (carbonic anhydrase inhibitors, citrates, sodium bicarbonate), ihe egwu nke kristalia na mmetụta nephrotic na-abawanye.

Ojiji nke ofloxacin na probenecid, cimetidine, furosemide, methotrexate na-eduga n'ịbawanye ụba nke ofloxacin na plasma ọbara.

N'oge nyocha ụlọ nyocha. N'oge ọgwụgwọ nke ofloxacin, enwere ike ịhụ nsonaazụ ụgha na-ekpebi opiates ma ọ bụ porphyrins na mmamịrị. Ya mere, ọ dị mkpa iji usoro ndị akọwapụtara akọwapụtara.

Ofloxacin nwere ike igbochi uto nke ụkwara nta Mycobacterium ma gosi nsonaazụ ụgha na ọmụmụ ihe banyere nje na-achọpụta ụkwara nta.