Torvacard - ntuziaka maka ojiji, nyocha, ụdị analogues na ụdị mwepụta (10 mg, 20 mg na mbadamba 40 mg) nke ọgwụ statin iji belata cholesterol ma gbochie ọrịa obi na okenye, ụmụaka na afọ ime.

N'isiokwu a, ị nwere ike gụọ ntuziaka maka iji ọgwụ Thorvacard. Ntugharị nke ndị ọbịa na saịtị - ndị na - eri ọgwụ a, yana echiche ndị ọkachamara n'ịgwọ ọrịa gbasara iji Torvacard statin na omume ha. Arịrịọ dị ukwuu bụ ịgbakwunye nyocha gị gbasara ọgwụ ahụ: ọgwụ ahụ nyeere aka ma ọ bụ enyereghị aka iwepụ ọrịa ahụ, ihe nsogbu na nsonaazụ ndị a hụrụ, ikekwe ọ bụ ọkwa onye nrụpụta na nkọwapụta. Analogs nke Torvacard n'ihu ọnụnọ analogues dị n'ụdị dịnụ. Jiri iji cholesterol belata ma gbochie ọrịa obi na okenye, ụmụaka, yana n’oge afọ ime na n’ara.

Thorvacard - egbugbere egbugbere ọnụ nke sitere na otu nke statins. Nhọrọ asọmpi ahọpụtara nke HMG-CoA reductase, enzyme nke na - agbanwe 3-hydroxy-3-methylglutaryl-coenzyme A na mevalonic acid, nke bụ ihe ga - ebido steroid, gụnyere cholesterol. N'ime imeju, a na-etinye triglycerides na cholesterol na VLDL, banye na plasma ọbara ma bufee ya na akwara anụ ahụ. Site na VLDL, a na-eke LDL n'oge mmekorita ya na ndị na-anabata LDL. Atorvastatin (ihe na-arụ ọrụ nke ọgwụ Torvard) na-ebelata plasma cholesterol (Ch) na lipoproteins site na igbochi HMG-CoA mbelata, ịgbakọ cholesterol na imeju na ịba ụba nke ndị na-anabata LDL na imeju na elu cell, nke na-eduga n'ịba ụba na catabolism nke LDL .

Atorvastatin na-ebelata nguzobe nke LDL, na-eme ka mmụba na nkwụsi ike na-anabata ndị na-anabata LDL. Torvacard na-agbadata ọkwa LDL na ndị ọrịa nwere hypercholesterolemia homozygous familial, nke na-adịkarịghị ọgwụgwọ.

Ọ na-ebelata ọkwa nke cholesterol zuru ezu site na 30-46%, LDL - site na 41-61%, apolipoprotein B - site na 34-50% na triglycerides - site na 14-33%, na-akpata mmụba nke nsonaazụ nke HDL-C na apolipoprotein A. Dose-dabere na-ebelata ọkwa nke LDL na ndị ọrịa nwere hypercholesterolemia homozygous na-eguzogide ọgwụ na ndị ọrụ hypolipPs.

Ngwakọta

Calcium + Atorvastatin.

Mlọ ọgwụ

Idopu ihe n’ulo di elu. Nri jiri nwayọ belata ngwa-ngwa na oge iwere ọgwụ (site na 25% na 9%, otu), mana mbelata nke LDL cholesterol yiri nke ahụ na iji atorvastatin na-enweghị nri. Ntinye uche nke atorvastatin mgbe etinyere ya na mgbede dị ala karịa n'ụtụtụ (ihe dịka 30%). E gosipụtara mmekọrịta kwụụrụ n’etiti ogosi nke itinye uche na ogo nke ọgwụ ahụ. Ọ bụ metabolized bụ na imeju. A na - apịpụta ya site na eriri afọ mgbe hepatic na / ma ọ bụ extrahepatic metabolism (ọ naghị eme ka a na-aghọrọghachi enterohepatic). Ọrụ inhibitory megide HMG-CoA reductase na-adịgide ruo ihe dị ka awa 20-30 n'ihi ọnụnọ nke metabolites na-arụ ọrụ. Ihe na-erughị 2% nke ọgwụ a na-ekpebi n’ime mmamịrị. Achọghị ya ka ọ dịrị n'oge ịba ọcha n'anya.

Ihe na-egosi

na nri iji belata ogo di elu nke cholesterol, cholesterol-LDL, apolipoprotein B na triglycerides ma nwekwuo cholesterol-HDL na ndị ọrịa nwere isi hypercholesterolemia, heterozygous ezinụlọ na hypercholesterolemia na-adịghị agakọ (jikọtara) hyperlipidemia (ụdị 2a na 2a) ,
tinyere nri iji gwọọ ndị ọrịa nwere ọrịa triglycerides dị elu (ụdị 4 dịka Fredrickson) yana ndị ọrịa nwere dysbetalipoproteinemia (ụdị 3 dịka Fredrickson), ebe ọgwụgwọ nri anaghị enye mmetụta zuru oke,
iji belata ọkwa nke cholesterol mkpokọta na LDL-C n'ime ndị ọrịa nwere hypercholesterolemia homozygous familial, mgbe usoro nri na usoro ọgwụgwọ ndị ọzọ anaghị agwọ ọrịa anaghị arụ ọrụ nke ọma (dị ka mgbakwunye na usoro ọgwụgwọ Lipid, gụnyere autohemotransfusion nke ọbara ọcha nke LDL),
ọrịa nke akwara obi (na ndị ọrịa nwere ike ibute ọrịa obi n'ihi akwara obi - ndị agadi karịrị afọ 55, na-a ,ụ sịga, ọbara ọgbụgba, ọrịa shuga, ọrịa vaskụla okirikiri, ọnya afọ, hypertrophy ekpe, protein / albuminuria, ọrịa akwara akwara na nso ndị ikwu. ), gụnyere megide ihe ndabere nke ọrịa dyslipidemia - prophylaxis nke abụọ na ebumnuche iji belata mkpokọta ọnwụ, myocardial infarction, ọrịa strok, ịmaliteghachi n'ụlọ ọgwụ maka angina pectoris na mkpa maka usoro mmughari.

Dị Mwepụta

10 mg, 20 mg na mbadamba ihe nkiri 40 mg.

Ntuziaka maka ojiji na usoro

Tupu nhọpụta nke Torvacard, onye ọrịa ahụ kwesịrị ikwu usoro nri nwere ike ịmịnye mmadụ azụ, nke ọ ga-agharịrị ịgbaso oge ọgwụgwọ.

Ọgwụ nke mbụ bụ nkezi nke 10 mg otu ugboro kwa ụbọchị. Ọgwụ dịgasị iche site na 10 ruo 80 mg otu ugboro n'ụbọchị. Enwere ike ị drugụ ọgwụ ahụ n'oge ọ bụla n'ụbọchị, n'agbanyeghị oge nri. A họrọ ọgwụ ahụ na-eburu n'uche usoro mbụ nke LDL-C, ebumnuche ọgwụgwọ na mmetụta nke onye ọ bụla. Na mbido ọgwụgwọ na / ma ọ bụ n'oge mmụba nke dose nke Torvacard, ọ dị mkpa iji nyochaa ọkwa nke plasma lipid kwa izu 2-4 ma degharịa ya otu a. Ogo kachasị kwa ụbọchị bụ 80 mg na 1 dose.

Na hypercholesterolemia bụ isi na hyperlipidemia agwakọtara, n'ọtụtụ oge, dose 10G nke Torvacard otu ugboro n'ụbọchị ezuola. A na-ahụkarị ọgwụgwọ ọgwụgwọ dị ukwuu ka izu abụọ gachara, dịka iwu, a na-ahụkarịkarị ọgwụgwọ ọgwụgwọ ka izu anọ gachara. Site n'ọgwụgwọ ruo ogologo oge, mmetụta a na-adịgide.

Mmetụta akụkụ

isi ọwụwa
asthenia
ehighi ura
anya ntughari
iro ụra
n’abali
amnesia
ịda mba
nsogbu neuropathy akụkụ
ataxia
paresthesia
ọgbụgbọ, vomiting,
afọ ntachi ma ọ bụ afọ ọsịsa
flatulence
mgbu afọ
nri na-elu nri,
myalgia
arthralgia,
myopathy
myositis
azu mgbu
cramps ụkwụ
akpụkpọ anụ?
ihe nwu
urticaria
angioedema,
nsogbu anaphylactic,
rashị rashes,
polymorphic exudative erythema, gụnyere Stevens-Johnson ọrịa
necrolysis na-egbu egbu (Lyell syndrome),
hyperglycemia
hypoglycemia,
obi mgbu
mgbago ọgụgharị,
enweghi ike
alopecia
tinnitus
I nweta ibu
malaise
adịghị ike
thrombocytopenia
nke abụọ gbasara akụrụngwa ọdịda.

Ihe ngbanwe

ọrịa ọrịa imeju na-arụ ọrụ ma ọ bụ mmụba na ọrụ nke transaminases n'ọbara ọbara (karịa ugboro atọ ma e jiri ya tụnyere VGN) sitere na mmalite amabeghị
mmebi imeju (ogo A na B n'ihe omumu Childmụaka),
ọrịa ndị na-eketa eketa, dịka ọrịa lactose, enweghị ụkọ lactase ma ọ bụ glucose-galactose malabsorption (n'ihi ọnụnọ nke lactose na ihe mejupụtara),
tụụrụ ime
lactation
womenmụ nwanyị dị afọ imu na-adịghị eji ụzọ zuru oke nke igbochi afọ ime,
andmụaka na ndị nọ n’agbata afọ iri na asatọ (anaghị adịzicha ike na nchekwa)
hypersensitivity na mmiri ọgwụ.

Ime na lactation

Torvacard bụ contraindicated na ime na lactation (inye ara).

Ebe obu na cholesterol na ihe ndi choputara n’ime cholesterol di nkpa maka mmepe nwa ebu n’afọ, ihe ọghọm nke igbochi HMG-CoA mbelata ga-erite uru nke iji ọgwụ n’oge afọ ime. Mgbe ị na-eji lovastatin (ihe na-egbochi HMG-CoA reductase) na dextroamphetamine na ọnwa atọ mbụ nke afọ ime, ọmụmụ nke ụmụaka nwere nrụrụ ọkpụkpụ, tracheo-esophageal fistula, na anus atresia. Ọ bụrụ n’ịchọpụta afọ ime n’oge ọgwụgwọ na Torvacard, ekwesịrị ịkwụsị ọgwụ a ozugbo, e kwesịrị ịdọ ndị ọrịa aka na ntị gbasara ihe nwere ike ibute nwa ebu n’afọ.

Ọ bụrụ na ọ dị mkpa iji ọgwụ mee ihe n'oge a na-enye nwa ara, nyere ohere nke ihe omume ọjọọ na ụmụ ọhụrụ, a ga-eleba anya n'okwu banyere ịkwụsị inye ụmụ ara.

Ojiji ndị ụmụ nwanyị topụtara ịmụ nwa ga-ekwe omume naanị ma ọ bụrụ na ejiri ụzọ mgbochi ogwu a pụrụ ịdabere na ya mee ihe. E kwesịrị ịgwa onye ọrịa ọrịa ahụ ihe o nwere ike ime ma nwa ebu n’afọ nweta ya.

Jiri na umuaka

A machibidoro ọgwụ a n'ime ụmụaka yana ụmụaka nọ n'afọ iri na asatọ (akwụbeghị ike na nchekwa).

Ntụziaka pụrụ iche

Tupu ịmalite usoro ọgwụgwọ Torvacard, ọ dị mkpa ịnwale iji nweta hypercholesterolemia site na usoro nri zuru oke, imega ahụ ike, ibu ibu na ndị ọrịa na oke ibu na ọgwụgwọ nke ọnọdụ ndị ọzọ.

Ojiji nke HMG-CoA reductase inhibitors iji belata egbugbere ọnụ ọbara nwere ike iduga mgbanwe na usoro biochemical nke na-egosipụta ọrụ imeju. Ekwesịrị ilebara ọrụ imeju anya tupu ịmalite ọgwụgwọ, izu isii, izu iri na abụọ mgbe ịmalitere Torvacard na mgbe ọ bụla na-abawanye, na kwa oge (dịka ọmụmaatụ, ọnwa 6). Enwere ike ịhụ mmụba na ọrụ nke enzymes hepatic na ọbara ọbara n'oge ọgwụgwọ na Torvacard (ọ na-abụkarị ọnwa atọ mbụ). Ekwesịrị inyocha ndị ọrịa nwere mmụba na ọkwa transaminase ruo mgbe ọkwa enzyme ga-alaghachi na nkịtị. N'ọnọdụ nke ụkpụrụ ALT ma ọ bụ AST karịrị VGN ugboro atọ karịa VGN, a na-atụ aro ka ibelata dose nke Torvacard ma ọ bụ kwụsị ọgwụgwọ.

Treatmentgwọ Torvacard nwere ike ibute myopathy (mgbu na adịghị ike, jikọtara ya na mmụba nke ọrụ CPK site na ihe karịrị ugboro 10 ma e jiri ya tụnyere VGN). Torvacard nwere ike ibute mmụba na CPK serum, nke ekwesiri iburu n'uche na nchọpụta ọdịiche nke mgbu obi. E kwesịrị ịdọ ndị ọrịa ọdụ na ha kwesịrị ịgakwuru dọkịta ozugbo ma ọ bụrụ na mgbu na-enweghị nkọwa ma ọ bụ adịghị ike nwere ahụ, ọ bụrụ na ọnya ma ọ bụ ahụ ọkụ na-eso ya. A ga-akwụsị ịgwọ ọrịa Torvard nwa oge ma ọ bụ kwụsị kpam kpam ma ọ bụrụ na enwere ihe mgbaàmà nke myopathy enwere ike ma ọ bụ ihe dị oke egwu maka ịmalite itolite akwara n'ihi rhabdomyolysis (dịka ọmụmaatụ, ọrịa siri ike, hypotension, nnukwu ịwa ahụ, trauma, metabolic siri ike, endocrine na electrolyte ọgba aghara na njikwa enweghị nchịkwa. )

Mmetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ

Achọghị mmetụta ọjọọ nke Torvacard n'ikike ịnya ugbo ala na itinye aka na ihe ndi ozo choro itinye uche na ngwa ngwa mmeghachi omume psychomotor.

Mkparịta ụka ọgwụ ọjọọ

Site na iji cyclosporine, fibrates, erythromycin, clarithromycin, ọgwụ immunosuppressive na antifungal nke otu azole, nicotinic acid na nicotinamide, ọgwụ ndị na-egbochi metabolism nke CYP450 isoenzyme 3A4, na / ma ọ bụ na ebugo ya adahade. Mgbe ị na-edepụta ọgwụ ndị a, a ga-eji nlezianya na-elele uru na ihe ize ndụ nke ọgwụgwọ anya, a ga-elebara ndị ọrịa anya mgbe niile iji chọpụta mgbu olu ma ọ bụ adịghị ike, ọkachasị n'oge ọnwa mbụ nke ọgwụgwọ yana oge ịba ụba ọgwụ ọ bụla, na-ekpebi ọrụ KFK kwa oge, n'agbanyeghị na njikwa a anaghị ekwe gbochie mmepe nke myopathy siri ike. A ga-akwụsị ịgwọ ọrịa Torvard ma ọ bụrụ na enwee mmụba dị ukwuu na ọrụ CPK ma ọ bụ ọ bụrụ na ekwenyela ma ọ bụ na-eche na myopathy.

Torvacard enweghị mmetụta ọfụma n'ụlọ ọgwụ na nsonaazụ nke terfenadine na plasma ọbara, bụ nke metabolized kachasị site na 3A4 CYP450 isoenzyme, yabụ o yighị ka atorvastatin nwere ike imetụta pịpatị pharmacokinetic nke mkpụrụ ndị ọzọ nke 3A4 CYP450 isoenzyme. N'iji oge nke atorvastatin (10 mg otu ugboro n'ụbọchị) na azithromycin (500 mg otu ugboro kwa ụbọchị), itinye uche nke atorvastatin na plasma ọbara anaghị agbanwe.

Site na ntinye nke atorvastatin na oge nke nwere magnesium na aluminom hydroxides, ntinye nke atorvastatin na plasma ọbara belatara ihe dika 35%, agbanyeghị, ogo mbelata ogo LDL-C agbanwebeghị.

Site na iji colestipol na-emekọ ihe ọnụ, plasma nke atorvastatin belatara ihe dị ka 25%. Agbanyeghị, mmetụta dị ala nke njikọta nke atorvastatin na colestipol karịrị nke ọgwụ ọ bụla n’otu n’otu.

Site na iji Torvacard n'otu oge emetụtaghị ọgwụ ọgwụ nke phenazone, yabụ, mmekọrịta na ọgwụ ndị ọzọ metabolized site na otu CYP450 isoenzymes anaghị atụ anya.

Mgbe ị na-amụ mmekọrịta nke atorvastatin na warfarin, cimetidine, phenazone, enweghị akara nke mmekọrịta mmekọrịta dị egwu.

Ojiji nke oge ọgwụ na -ebelata mkpokọta homonụ steroid endogenous (gụnyere cimetidine, ketoconazole, spironolactone) na-abawanye ohere nke belata homonụ steroid endogenous (ịkpachara anya kwesịrị ịkpachara anya).

Enweghị mmekọrịta dị omimi nke atorvastatin na ọgwụ antihypertensive, yana ndị estrogens.

Site na iji Torvacard na-eme n'otu oge na 80 mg kwa ụbọchị yana ọgwụ mgbochi nwere norethindrone na ethinyl estradiol, ọnụọgụ dị elu nke northindrone na ethinyl estradiol hụrụ ihe dịka 30% na 20%, n'otu n'otu. E kwesịrị ịtụle mmetụta a mgbe ị na-ahọrọ ọgwụ mgbochi ọgwụ maka ụmụ nwanyị na-anata Torvacard.

Site n’otu oge eji atorvastatin na dose nke 80 mg na amlodipine na ọgwụ nke 10 mg, ọgwụ ọgwụ nke atorvastatin na steeti ohi ahụ agbanweghị.

Site na nchịkwa digoxin na atorvastatin ugboro ugboro na 10 mg, ikike itinye digoxin na plasma ọbara agbanweghị. Agbanyeghị, mgbe ejiri digoxin na atorvastatin na ọgwụ nke 80 mg kwa ụbọchị, ịba ụba nke digoxin mụbara ihe dịka 20%. Ndị ọrịa na-anata digoxin yana atorvastatin chọrọ nlebara anya.

Emebeghị nnyocha banyere mmekọrịta n'etiti ọgwụ ndị ọzọ.

Analogs nke ọgwụ Torvacard

Anakpụrụ nke analogues nke na-arụ ọrụ:

Anvistat
Atocord
Atomax
Atorvastatin
Atorvox
Atoris
Vazator
Lipona
Lipoford
Liprimar
Liptonorm,
Torvazin
Ihe eji agwu Tulip.

Analogs na otu ọgwụ ọgwụ (statins):

Akorta,
Na-eme ihe
Anvistat
Apextatin,
Atherostat
Atocord
Atomax
Atorvastatin
Atorvox
Atoris
Vazator
Vasilip
Zokor
Zokor Forte
Zorstat
Cardiostatin
Crestor
Lekol,
Leskol forte
Lipobay,
Lipona
Lipostat
Lipoford
Liprimar
Liptonorm,
Lovacor
Lovastatin
Lovasterol
Mevacor
Medostatin,
Mertenil
Aries
Pravastatin,
Rovacor
Rosuvastatin,
Rosucard,
Rosulip,
Roxer
SimvaHexal,
Simvakard,
Simvacol
Simvalimite
Simvastatin
Simvastol
Simvor
Simgal
Simlo
Igha iyi
Tevastor
Torvazin
Ihe eji agwu Tulip
Holvasim
Holetar.

Ihe ngosi maka ojiji

Torvacard 10 mg

Edere mbadamba dị ka akụkụ nke ọgwụgwọ zuru oke.Gịnị ka eji Torvacard mee? Edere ọgwụ ahụ maka ndị ọrịa na-arịa oria ndị a:

N'ihe banyere hypercholesterolemia nke mbụ, hyperlipidemia (ihe nketa, nke na-abụghị ihe nketa ma jikọtara ọnụ), a na-enye usoro nri n'oge ọgwụgwọ na-ebelata cholesterol na triglycerides (ọ bụrụ na, dị ka nsonaazụ nke nyocha ahụ si gosi, ihe ndị a na-abawanye ụba),
Site na mmụba n'ọbara nke triglycerides (ụdị 4 hypertriglyceremia dịka Frederickson) siri cholesterol na lipoprotein metabolism (abetalipoproteinemia na hypobetalipoproteinemia - ezinụlọ dsetalipoproteinemia),
Site na cholesterol zuru oke na mmụba nke mkpokọta lipoproteins dị ala na njikọta hypercholesterolemia homozygous.
Dysfunction of the cardiovascular system (ischemia, diabetes mellitus, ọbara mgbali, obterating atherosclerosis, syndrome diabetes ụkwụ, thrombosis peripheral),
Ihe mgbochi nke abuo nke nsogbu sitere na infarction myocardial, ọrịa strok, angina pectoris.

Ọzọkwa, a na-enye ndị ọrịa nwere ihe dị oke egwu maka mmepe nke ọrịa obi obi (ị ,ụ sịga, ọrịa shuga, ogo agadi).

Ntụziaka maka iji Torvacard na usoro onunu ogwu

N'oge ọgwụgwọ, onye ọrịa ahụ kwesịrị ịrapara na hypocholesterolemic nri (mgbochi nke nnu, eghe, nri abụba, iji ọka, akwụkwọ nri, mmiri).

Dịka ntuziaka maka iji Torvacard, a na-ewere mbadamba kpamkpam (n'ime), n'agbanyeghị nri na oge ụbọchị. A na-eme ọgwụgwọ dịka atụmatụ ahụ si dị. Usoro ọgwụgwọ mbụ bụ mgomenti iri (otu ugboro kwa ụbọchị). Mgbe ahụ ọnụego ọgwụ a na-abawanye na, dabere na nchọpụta dị nro, ọgwụ a na-enweta kwa ụbọchị bụ site na iri ruo iri asatọ mg.

N'oge usoro ọgwụgwọ, a na-enyocha onya dị n'ọbara kwa izu abụọ. Nke a na-enye ohere maka idozi usoro ọgwụgwọ oge.

Njirimara nke ngwa Torvacard:

- Site na hypercholesterolemia nke homozygous, usoro a na-atụ aro kwa ụbọchị bụ 80 mg,
-Aghazi usoro onunu ogwu ya n’ujo imeju ya na akuru aru oru,
- Ahụmịhe nke ịkọwa na omume ụmụaka adịghị obere, yabụ, ụmụaka nọ n'okpuru ụlọ ọgwụ n'oge ọgwụgwọ (iji zere mmeghachi omume a na-atụghị anya ya na ọgwụ ahụ),
- Ndị okenye na-anabata mbadamba mbadamba nke ọma, yabụ na-achọghị ndozi nke dose.

A na-atụ aro ndị ọrịa na-eji ọgwụ anticoagulant ma ọ bụ ọgwụ coumarin, tupu oge nke Torvacard, mee nyocha maka PV (oge prothrombin). Ekwesịrị ilezi anya mgbe ejikọtara ya na ndị na-egbochi HMG-CoA reductase inhibitors na fibrates.

Contraindications na ịdoụbiga mmanya ókè

Mbadamba nwere ọtụtụ contraindications, yabụ, nke dọkịta depụtara ka nyochachara nke onye ọrịa ahụ. A naghị akwado iji ọgwụgwọ ọrịa Torvacard:

Hypersensitivity na isi ihe dị n'ọrụ ma ọ bụ ihe ndị ọzọ (magnesium oxide, microcrystalline cellulose, lactose monohydrate, magnesium stearate),
Ọrịa imeju na-arịa ya
Enzymes imeju na-agbasa nke etiology na-amaghị,
Undermụaka na-erubeghị afọ 18 (nchekwa, ịdị irè na ịnagide ọgwụ ahụ edobebeghị ọgwụ), ewezuga ọgwụgwọ heterozygous familial hypercholesterolemia,
Nlekọta oge nke ndị na-egbochi nchebe (n'ịgwọ nje HIV).

Edeghị ọgwụ a ka ụmụ nwanyị nye ya ọgwụ. Ebe ọ bụ na atorvastatin na-abanye n’a breastụ ara, egosighi ya n’oge a na-ehi ụra.

site na akwara dị n’etiti - nsogbu ọgbụgba, migraine, dizzness, mmetụta uche, ike ọgwụgwụ,
site na ngwara nri - ọgbụgbọ, ọgbụgbọ, ọgbụgba, ọnya afọ, mgbu nke imeju, umeji akwara.
n’akụkụ akwara uru - akwara na nkwonkwo, ihe na-eme n’ọkpụkpụ akwara ike (rue mbibi akwara akwara).

Ọ ga - ekwe omume mmepe nke mmeghachi omume nfụkasị - nchapu nke anụ ahụ, ọdịdị nke obere ihe ọkụ ọkụ, itching, adịkarịghị - urticaria.
Dodoụbiga mmanya ókè na-apụta n'ihi ọgwụgwọ na-aga n'ihu ogologo oge ma ọ bụ na-emegide nzụlite otu oke ị doụ ọgwụ. N'okwu a, a na-anabata onye ọrịa n'ụlọ ọgwụ, a na-enye ọgwụ ọgwụgwọ Symptomatic. Usoro ọgwụgwọ adịghị irè.

Torvakard analogues, ndepụta

Torvacard, dịka ọgwụ ndị ọzọ na atorvastatin, na-enye ya n'ụlọ ahịa ọgwụ na-enweghị ndenye ọgwụ. Mana nke a apụtaghị na onye ọrịa nwere ike jiri aka ya họrọ ọgwụ ọzọ, nke onye na-ere ọgwụ nwere ike dị ọnụ ala ma ọ bụ kwụọ ya.

Ọ bụrụ na mbadamba Torvard adịghị mma maka onye ọrịa ahụ, dọkịta ahụ nwere ike ịkọ ọgwụ analogues:

Ihe dị mkpa - ntuziaka maka iji Torvacard, ọnụahịa na nyocha anaghị emetụta analogues, enweghị ike iji ya dịka nduzi maka ojiji nke ọgwụ nke mejupụtara ma ọ bụ omume. Oge ọ bụla dọkịta ga-eme ọgwụgwọ, kwesịrị inwe dọkịta. Mgbe ị na-eji dochie dochie Torvacard, ọ dị mkpa ịnweta ndụmọdụ ọkachamara, ị nwere ike ịgbanwe usoro ọgwụgwọ, usoro ọgwụgwọ, wdg Emekwala ọgwụ onwe gị!

A na-enye ọgwụ ọgwụ niile ka ọ belata kọlestrọl, obere lipoproteins dị ala na triglycerides na isi ma ọ bụ hypercholesterolemia. Akara analogs nke Torvacard nwekwara otutu contraindications, yabụ a na-enyocha onye ọrịa maka ihe mgbochi anụ ahụ tupu, mgbe yana mgbe ọgwụgwọ gasịrị. Nyocha ndị dọkịta na-ekwu banyere ọgwụ dị mma: ọgwụ ahụ, dị ka a na-achị, na-anabata nke ọma - nsonaazụ ya na-etolite na-adịghị ahụkebe, na usoro ọgwụgwọ ahụ dị nnọọ mfe ikpebi.

Omume ọgwụ

Na-ezo aka na otu akpụ ma zighaa ya Mmetụta egbugbere ọnụ. Na-egbochi oke ma ọfụma na enzyme dị na njikọ ahụ cholesterol.

Triglycerides cholesterol na - eme ihe mejupụtara atherogenic lipoprotein n'ime imeju, a na-ebugharị ọbara n'ọkwa. Site na iso ndi nnabata lipoproteinsha buru ibu ha na-agbanye n'ime lipoproteins ndị a.

Site na igbochi HMG-CoA reductase, a na-ebelata lipoproteins na cholesterol n’ime ọbara. Ndalata LDL njikọ na ụba ọrụ nke ndị na-anabata ha.

Ọgwụ nwere ike belata ego nke LDL na homozygous hypercholesterolemia ihe nketa, mgbe ọgwụ ndị ọzọ enweghị mmetụta.

Ọgwụ na-ebelata cholesterol site na 30-46%, atherogenic lipoproteins site na 41-61%, triglycerides na 14-33% ma na-abawanye ọdịnaya nke lipoproteins na antiatherogenic Njirimara.

Pharmacodynamics na pharmacokinetics

N'ime ọbara, oke ọgwụ dị n'obara na-apụta n'ime nkeji 60-120. Nri na-ebelata mmata, ma wedata cholesterol yiri nke na-enweghị nri. N'ihe banyere itinye mgbede, ịka ọgwụ dị obere karịa mgbe ewere ya n'ụtụtụ.

Site na protein protein na - ejikọ aka na 98%. Ọ bụ metabolized na imeju na nguzobe nke metabolites nọ n'ọrụ.

Apụrụ ya na bile, ọkara ndụ ahụ bụ awa 14. A na-ejikwa ịdị irè nke ọgwụ ahụ n'ihi metabolites na-arụ ọrụ ruo awa iri atọ. Site na iji okpokoro akwara adighi egosiputa.

Ihe ngosi Torvakard

Mbadamba Torvacard - gịnị ka ha sitere?

Ejiri ọgwụ a jikọta ya na nri maka:

mbelata larịị cholesterolatherogenic lipoproteins, triglycerides, apolipoprotein B na mmụba na HDL na hypercholesterolemia, heterozygous na mgbakwunye hypercholesterolemia (ụdị Fredrickson IIa na IIb),
ọgwụgwọ nke ndị ọrịa n’ime ha ihe ha na abawanye triglycerides n'ọbara (ụdị nke IV dịka Fredrickson) na ụdị III dịka Fredrickson (dysbetalipoproteinemia) si bụrụ na nri anaghị eweta nsonaazụ.
belata cholesterol na LDL na homozygous ụdị ezinụlọ hypercholesterolemia,
ọgwụgwọ nke obi na ọrịa vaskụla ọnụnọ nke ihe dị elu maka ihe na - akpata ọrịa obi.ọbara mgbali ikendị ọrịa karịa afọ 55 ọria aru na anamnesis, albuminuriaọbara mgbali ume aka ekpe ventricle, ise anwụrụ, ọrịa vaskụla akụkụ,Ọrịa ọrịa obi Ischemic n’ezinụlọ ọrịa shuga mellitus).

Ihe kacha egosi Torvacard bụ ịdọ aka na ntị nke abụọ infarction myocardialọnwụ mmughariọrịa strok na ndabere dyslipidemia.

Ihe ngbanwe

nnukwu mmebi imeju,
ọkwa di elu transaminase n’ime ọbara
ihe nkwekọ maka ihe glucose na lactose, ụkọ lactase,
womenmụ nwanyị nọ n'afọ ọmụmụ adịghị eji ya ogwu mgbochinwa,
tụụrụ ime na inye ara,
ụmụaka na-erubeghị afọ 18
mmadu anabataghi ya.

Jiri nwayọ maka ọrịa metabolic na metabolic, ọbara mgbali ike, a .ụrụmabufee ọrịa imeju sepsis, mgbanwe na mmiri-electrolyte iyuzu oke, na ọrịa shuga, Akwụkwụ na-adọ, mmerụ ahụ na nnukwu ịwa ahụ.

Nsonaazụ

Akụkụ Alimentary: afọ mgbu, dyspepsiaọgbụgbọ na ọgbụgbọ, ọgbụgba na -akpata, mgbanwe na agụụ, ọria aru na ịba ọcha n'anya, jaundice.

Usoro akwara: mgbu na nkwonkwo na akwara, na azụ, cramps na olu nke ụkwụ, myositis.

Abughi ndi ime ụlọ nyocha: mgbanwe nke ọkwa glucosemmụba ọrụ enzymes imeju na phosphokinase creatine n’ime ọbara.

Ngosiputa ndi ozo puru ibu mpaghara oria, obi mgbu, tinnitus, isi, ike adighi aru, enweghi ike, ọdịda akụrụngwa nke ọdịdị nke abụọ, mbelata ọnụ ọgụgụ platelet.

Erere cholesterol n'ọnọdụ ụfọdụ dugara na ya ịda mba, imebi arụmọrụ mmekọahụ, obere ihe nke mebiri ngụgụ nke ngụgụ, ọrịa shuga (mmepe na-esite n’ihe ndị dị ize ndụ - glucose na-ebu ọnụ, ọbara mgbali elu, akwara uka, hypertriglyceridemia).

Ntụziaka maka iji Torvacard (Usoro na usoro onunu ogwu)

N'oge ọgwụgwọ, onye ọrịa ahụ ga-ekwenyere nri ivu.

Usoro ọgwụgwọ na-amalite site na 10 mg kwa ụbọchị, emesịa mụbaa na 20 mg. Usoro ọgwụgwọ kwa ụbọchị bụ site na 10 ruo 80 mg. A hotara dose ahụ na-elebanye anya na usoro nyocha ụlọ nyocha na njirimara mmadụ.

A na-ewere ọgwụ ahụ n'agbanyeghị nri.

Tupu iwere na, ọ bụrụ na ọ dị mkpa, na-edozigharị ọnya, a na-eme nyocha ụlọ nyocha nke ogo nke ara.

Mmetụta nke ngwa a na-apụta mgbe ụbọchị iri na anọ gachara.

Maka ọgwụgwọ ndị ọrịa na-ahụ maka homozygous hypercholesterolemia otu n'ime ọgwụ ole na ole na-enye ihe na-akpata bụ Torvacard, ntuziaka maka iji kọwaa nke ọma kwa ụbọchị, nke bụ 80 mg.

Mmekorita

Iji ọgwụ ndị na-egbochi metabolism nke enzyme CYP450, erythromycinantifungal na immunosuppressive ọgwụ, fibrates, cyclosporine, clarithromycin, nicotinamide, nicotinic acid ịta Torvacard n'ọbara na-abawanye. N'otu oge ahụ, a na-amụba ike myopathy, ya mere ọ dị mkpa ịchịkwa ọkwa nke CPK n'ọbara.

Nkwonkwo nnabata ego na aluminom hydroxide ma obu magnesium na-ebelata ịta Torvacard, mana nke a anaghị emetụta arụmọrụ ya.

Njikọ na colestipol na-ebelata ịta atorvastatinmana nkwonkwo ha Mmetụta egbugbere ọnụ karịrị nke ọ bụla.

N'ikuku ogwu gboro ya na kwa ụbọchị nke Torvacard 80 mg na-abawanye ọdịnaya ahụ ethinyl estradiol n’ime ọbara.

Jiri na yana digoxin na-ebelata ịta nke ikpeazụ site na 20%.

Ntụziaka pụrụ iche

Tupu ọgwụgwọ, ịkwesịrị ịgbalị iji belata cholesterol na nri, ọgwụgwọ oke ibu na ọrịa na-efe efe, na-emega ahụ.

N'oge ọgwụgwọ, ọ dị mkpa ịchịkwa ọkwa nke AST na ALT. Maka oge izizi, a na-ebu njikwa n’ihu, ka izu isii na ọnwa atọ gachara ọgwụ, yana ịhazigharị otu ugboro kwa ọnwa isii. Ọ bụrụ na ọkwa nke enzymes na-ebili karịa ugboro atọ, ịkagbu ọgwụ ahụ.

Tornweta Torvacard nwere ike ime ka ike gwụ akwara na mgbu (myopathies) na mmụba na CPK n'ime ọbara. Ọ bụrụ na inwee mgbu mgbu ma ọ bụ adịghị ike na njikọta ahụ, ị kwesịrị ịkpọtụrụ dọkịta.

A na-akagbu ọgwụ ahụ ka ọghọm nke akụrụ gbasara arụrụala n'ihi rhabdomyolysis. Ọ nwere ike bụrụ trauma, arụmọrụ buru ibu, metabolic na elektrik, hypotension akwaraọrịa siri ikeogwe.

Nri Torvacard nwere ike iduga mmepe ọrịa shuga mellitus n'ime ndị ọrịa nwere nnukwu ihe egwu. Mana ekwesiri icheta na uru ị na-ewere statins dị elu karịa ihe ọ bụla na-arịa ọrịa shuga, yabụ na ọ dịghị mkpa ịkagbu ọgwụ ahụ, ndị ọrịa nọ n'ihe ize ndụ kwesịrị ịdị n'okpuru nlekọta dọkịta.

Nyocha na Torvakard

Nyocha ndị ahụ nke Torvacard dị na nzukọ a na-enye anyị ohere ikwubi na ọgwụ ahụ zuru oke. Ndi dibia bekee edeputara ya n’ebe di ala. cholesterol na ichekwa ndi oria site na ọrịa strok na obi ọgụ. Ka ọnwa 1-2 gachara, a na-ahụta mbelata nke kọlestrọl. Womenfọdụ ụmụ nwanyị na-egosi mmetụta dị mma - oke ibu.

N'ime adịghị ike enwere ike ịkpọ eziokwu bụ na ọgwụ cholesterol nwere ike ịkpata ehighi ura na itchy anụ ahụ ọkụ.

Ngwakọta, ụdị ọgwụ na ọnụahịa

Na mbadamba ihe convex, kpuchie ya na fim, nwere nnu calcium atorvastatin na ọnụọgụ 10, 20 ma ọ bụ 40 g. Kwado isi ihe:

Microcrystalline na hydroxypropyl cellulose,
Magnesium oxide na stearate,
Croscarmellose sodium
Lactose n'efu
Hypromellose,
Silica
Titanium dioxide
Macrogol 6000,
ntụ ntụ talcum.

Ọgwụ ọgwụ. Maka Torvacard, ọnụahịa dị n'usoro ụlọ ahịa ọgwụ dabere na usoro ha si nwee na njupụta dị na igbe, dịka ọmụmaatụ, Torvacard 20 mg, ọnụahịa ahụ bụ mbadamba 90. –1066 ite.

10 mg, 30 pcs. - 279 rubles,
10 mg, 90 pcs. - 730 rubles,
20 mg, 30 pcs. - 426 rub,
40 mg, 30 PC. - 584 rubles,
40 mg, 90 PC. –1430 rub.

Ogwu ahu dabara adaba maka oge 4, onaghi acho onodu puru iche maka nchekwa ya.

Mlọ ọgwụ

Torvacard ọgwụ na-eme ihe na-egbochi mgbochi HMG-CoA, na-egbochi ọnụego cholesterol. Cholesterol, triglycerides, lipoproteins nọ na sistem okirikiri na ebe ahụ.

Ọdịnaya dị elu nke cholesterol mkpokọta (OH), LDL na apolipoprotein B bụ ihe dị ize ndụ maka atherosclerosis na nsogbu ya, ọkwa HDL zuru ezu na-ebelata, na ntụle, ndị na-egosi ndị a.

Na nyocha anụmanụ, achọpụtara na statin na -ebelata mkpokọ cholesterol na LP, na-egbochi HC-CoA reductase ma na -emepụta kọlestrọl. Onu ogugu ndi cholesterol choro cho kariri na abawanye, na - eme ka nnabata nke udiri mmanu a diwanye nma. Na-ebelata nsụkọta atorvastine na LDL.

Torvacard na-enyere aka belata ọnụ ọgụgụ ụlọ oriri na nkwari akụ na OS, VLDL, TG, LDL, ọbụlagodi ndị ọrịa nwere hypercholesterolemia na-abụghị nke ezinụlọ na dyslipidemia, na-adịkarị azaghachi ọgwụ ndị ọzọ.

Enwere ihe akaebe nke mmekọrịta dị n'etiti ọnwụ dị na pathologies nke obi na akwara ọbara na ọdịnaya nke LDL na OH yana nke na-enweghị atụ maka HDL.

Torvacard na metabolites ya na-arụ ọrụ nke ọgwụ ahụ maka ahụ mmadụ. Isi ebe ha bu n’uju bu imeju, bu nke n’aru oru nke cholesterol na ikpochapu LDL. E jiri ya tụnyere usoro nke ọgwụ a, usoro onyonyo nke Torvacard na-agbakwụnye ịdị uchu karịa na mbelata ọkwa LDL.

A na-ahọrọ otu onye dabere na nsonaazụ nke mmeghachi omume ọgwụgwọ.

Mlọ ọgwụ

Egwu. Ọgwụ ahụ na-etinye obi gị dum na eriri afọ mgbe ejiri ya rụọ ọrụ, na-eru ntinye uche kachasị n'ime otu awa. Ọkwa nke Torvacard na-abawanye ụba. Ya bioavailability dị na 14%, ọkwa nke ọrụ inhibitory megide HMG-CoA reductase bụ 30%. A na-akọwapụta ngosipụta nke bioavailability dị ala site na nhichapụ usoro nhazi nke eriri afọ na usoro biotransformation na imeju. Nri na-echekwa etu esi a drugụ ọgwụ, mana nri dị iche ma ọ bụ jikọọ ọgwụ na ọgwụ anaghị emetụta mbelata nke cholesterol “ọjọọ”. Ọ bụrụ na ijiri statin na mgbede, a na-ebelata nsonaazụ ya na 30%, mana ọdịda a anaghị emetụta mbelata ogo cholesterol.
Nkesa. Ihe karịrị 98% nke ihe arụ ọrụ na-egbochi protein protein. Nnwale na oke gosiri na ọgwụ nwere ike ịbanye na mmiri ara ara.
Metabolism. Ọgwụ a bụ metabolized nke ukwuu. Ihe dị ka 70% nke ọrụ inhibitory ya na-emegide HMG-CoA reductase bụ nke ndị metabolites na-enye.
Ojiji. A na-ewepụ ọtụtụ n’ime atorvastine na ihe ndị dị na ya na bele mgbe ọ nwesịrị imeju. Ndụ ndụ ndụ nke statin ga-abụ awa elekere iri na anọ. Mgbe ị aụsịrị ọgwụ, ọ bụghị ihe karịrị 2% ọgwụ na-abanye na mmamịrị.
Mmekọahụ na atụmatụ afọ. N'ebe ndị tozuru etozu tozuru oke, pasent nke statin ọdịnaya dị elu karịa na ndị na-eto eto, ya mere, ogo mbelata ọkwa LDL dị ukwuu. N'ime ụmụ nwanyị, ọdịnaya Torvacard dị n'ọbara dị elu, mana ihe a anaghị emetụta ọnụego mbelata na LDL. Enweghị ihe akaebe banyere mmeghachi omume ụmụaka na Torvacard.
Ọrịa ọgbụgba. Mbelata mmerụ ahụ emetụtaghị ọkwa statin ma ọ chọghị ime mgbanwe ọ̀gaghị. Nwepụ ọgwụ ọ ga - eme ka ọ ghara ịkwalite nhụcha ọbara, ebe ọ bụ na ọgwụ atorvastine na-ejikọ nke ọma na protein.
Ọrịa ịba ọcha n'anya. Ọrịa imeju metụtara ị alcoholụbiga mmanya ókè nwere mmetụta na ọkwa nke ọgwụ n'ọbara: ọdịnaya ya na-abawanye nke ukwuu.

Ndakọrịta Torvacard na ọgwụ ndị ọzọ

Ihe omuma a gosiputara dika mgbanwe otutu oge bu nha nke ikpe nke oge ogwu na Torvacard naanị.

Ozi a gosipụtara na nha pasent bụ ọdịiche dị na data gbasara iji Torvacard iche. AUC - mpaghara dị n'okpuru usoro na-egosi ọkwa nke atorvastatin ruo oge ụfọdụ. C max - ọdịnaya kachasị elu nke ihe oriri n'ime ọbara.

Ọgwụ maka ojiji ya na usoro onunu ogwu

DoseMgbanwe nke AUCNgbanwe C _max Cyclosporin 520 mg / 2r. / ụbọchị, mgbe niile.10 mg 1 p./day ke usen 288.7 p.10,7 r Saquinavir 400 mg 2 p./day / Ritonavir 400 mg 2 p./day, 15 ụbọchị40 mg 1 p./day maka 4 ụbọchị3,9 p.4,3 p. Telaprevir 750 mg mgbe awa 8, 10 gasịrị.20 mg RD7,8 p.10,6 p. Itraconazole 200 mg 1 p. / ụbọchị, ụbọchị 4.40 mg RD.3,3 p.20% Clarithromycin 500g 2 r./day, 9 ụbọchị.80 mg 1 p./day Maka ụbọchị 84,4 r5,4 p. Fosamprenavir 1400 mg 2 p./day, 14.10 mg otu ugboro kwa ụbọchị maka ụbọchị 4.2,3 p.. 4.04 p. Ihe ọ juiceụpeụ mkpụrụ osisi grape, 250 ml 1 r / ụbọchị.40 mg 1 p./day n37%16% Nelfinavir 1250 mg 2 p./day, 1410 mg 1 p./day na 28 d74%2,2 p. Erythromycin 0.5g 4 r./day, 7 ụbọchị.40 mg 1 p./day51%Enweghị mgbanwe Diltiazem 240 mg 1 p./day, 28.80 mg 1 p./day15%12% Amlodipine 10 mg, otu ọgwụ10 mg 1 p./day33%38% Colestipol 10 mg 2 p / ụbọchị, izu 28.40 mg 1 p./day maka izu 28amaghi26% Cimetidine 300 mg 1 r./day, izu anọ.10 mg 1 p./day maka izu abụọihe ruru 1%11% Efavirenz 600 mg 1 r./day, 14.10 mg maka 3 ụbọchị.41%1% Maalox TC ® 30 ml 1 r./day, ụbọchị 17.10 mg 1 p./day n'ihi na 15 ụbọchị33%34% Rifampin 600 mg 1 p./day, 5 ụbọchị.40 mg 1 p./day80%40% Fenofibrate 160 mg 1 p./day, 7 ụbọchị.40 mg 1 p./day3%2% Gemfibrozil 0.6 g 2R./day., 7 ụbọchị.40 mg 1 p./day35%ihe ruru 1% Boceprevir 0.8g 3 r./day, 7 ụbọchị.40 mg 1 p./day2,30 p.2,66 p.

Ihe ize ndụ nke ọrịa akwara ọkpụkpụ (rhabdomyolysis) dị mgbe Torvacard batara na ọgwụ na-abawanye ọkwa ya. Ọ dị ize ndụ ijikọta ya na cyclosporine, styripentol, telithromycin, clarithromycin, delavirdine, ketoconazole, voriconazole, posaconazole, itraconazole na HIV inhibitors.

Ọtụtụ mgbe, a na-ahọrọ analogues na-adịghị emekọrịta na Torvacard. Ọ bụrụ n’agbanyeghi mkpebi emere iji jikọta ha, ha na-agbakọ ọghọm na uru ọgwụgwọ dị otú ahụ.

Statins na fusidic acid ekwekọghị: a kagbuo atorvastatin maka usoro ọgwụgwọ acid.

Ọ bụrụ na onye ọrịa ahụ na-a drugsụ ọgwụ nke na-abawanye ọkwa statin na ọbara, a na-enye obere ọgwụ Torvacard opekempe. Achọrọ nlekọta zuru oke nke ndị ọrịa dị otú a.

Studiesfọdụ ọmụmụ na-ekwu na statins nwere ike dịkwuo sugar sugar. Ndị ọrịa na-arịa ọrịa shuga nwere ike ịchọ ọgwụgwọ antidiabetic. Ma ọ bụrụ na i jiri ihe egwu a tụnyere ihe nwere ike imebi akwara, yabụ ojiji iji statins ga-abụ ihe ziri ezi.

Ndị nnọchi anya ndị otu nọ n'ihe ize ndụ (shuga agụụ ruo 6.9 mmol / l, BMI> 30 n'arọ / m2, oke nke triglycerol, ọbara mgbali elu) na-enyocha usoro biochemical na ọnọdụ ọnọdụ ahụ.

Componentsfọdụ akụrụngwa inyeaka nwekwara ike bute nsonaazụ na-achọghị. Iji maa atụ, lactose adabaghị maka ịkpa ókè galactose ma ọ bụ enweghị ụkọ lactase.

Ndị ọrịa nwere ọrịa obi na ọrịa obi na ọrịa nwere ọrịa angina pectoris Torvacard edepụtara na usoro nri.

Torvacard: ihe ngosi na contraindications maka ojiji

Ndi okenye n’enweghi ihe iriba ama na oria obi, ma ihe nwere ike ime ka oria ya puta (oke obia, anwuru anwu, onyunyo ala, HDL, ihe osiso n’enwe oria oria obi), ka enyere ogwu maka igbochi oria, myocardial infarction, na mbelata ihe ize ndu site na usoro itughari.

Didị ndị ọrịa shuga na-enweghị ihe mgbaàmà nke ọrịa obi, ma enwere ihe ndị dị ize ndụ dịka ọrịa retinopathy, albuminuria (protein na mmamịrị na-egosi ọrịa akụrụ), ise anwụrụ ma ọ bụ ọbara mgbali, statin ka enyere iwu maka igbochi nkụchi obi na ọrịa strok.

Site na ọrịa obi na-arịa oke akwara, a na-enye atorvastatin maka igbochi ọrịa obi ọgụ na ọrịa obi na-egbu egbu, iji mee ka usoro ịmụgharị dịghachi, na iji belata ihe ọghọm n'ụlọ ọgwụ maka ihe omume obi mkpọchi.

Na hyperlipidemia, e gosipụtara ọgwụ Tovakard na nri na-ebelata ihe ngosi nke cholesterol "ọjọọ" na triglycerol ma melite HDL.

Edebela Torvacard maka ọrịa ọrịa imeju na ọkwa arụmọrụ yana mmụba n'ihe omume nke atorvastatin.

Thorvacard n'oge ime

Ime, yana ụmụ nwanyị ndị ahụ nwere ike ime, anaghị eji Torvacard eme ihe, ebe ọ bụ na akpụkpo ahụ dị ize ndụ nye nwa ebu n’afọ. Ndị ọrịa oge ịmụ nwa kwesịrị ịbụ oke ọrụ n'ịhọrọ ọgwụ mgbochi.

N'agbanyeghị na ị dị ime, pasent nke kọlestrọl na triglycerol dị elu karịa nke ọma. Ọgwụ hypoliplera dị na nke a abaghị uru, n'ihi na cholesterol na ihe ndị dị na ya dị mkpa maka ịmalite ọmụmụ nwa zuru oke.

Atherosclerosis bụ ọrịa na-adịghị ala ala ma ọ na-etolite ruo ọtụtụ iri afọ, yabụ, mkpokọ mkpụmkpụ mkpụmkpụ mkpụmkpụ agaghị emetụta usoro hypercholesterolemia.

Maka Torvakard, omumu ihe banyere ọgwụ a a di na nwa a na-enye ya ara. Mana n'ozuzu, statins na-enwe ike ịbanye na mmiri ara ara, na-akpata mmetụta na-adịghị mma na ụmụ ọhụrụ. Ya mere, ọ bụ ihe amamihe dị na ụmụ nwanyị na-ewere Torvacard nyefee nwa ahụ nri na-edozi ahụ.

Usoro onunu ogwu na nhazi

Na hyperlipidemia na dyslipidemia, usoro mbụ nke ọgwụ Tovakard ọgwụ na-atụ aro n'ime 10-20 mg / ụbọchị. Ọ bụrụ na cholesterol ga - ebelata 45% ma ọ bụ karịa belata, ị nwere ike ịmalite na 49 mg / ụbọchị. Oke izugbe nke usoro onunu ogwu di 10-80 mg / day.

10mụaka 10-17 gbara afọ na heterozygous hypercholesterolemia na-amalite usoro ahụ na 10 mg / ụbọchị. Maximumkpụrụ kachasị nke Tovacar ruru 20 mg / ụbọchị. Onweghi data banyere mmeghachi omume ụmụaka na usoro ọgwụgwọ dị oke njọ. Gbazie ọnụego ahụ kwa izu anọ ma ọ bụ karịa.

Ọ bụrụ na akụkọ banyere hyzycholesterolemia nke homozygous hypercholesterolemia, usoro onunu ogwu nke Torvacard bụ 10-80 mg / ụbọchị. A na-eji Statin mee ihe na ọgwụ ndị na-eme ka mmiri ghara ịdị ala, yana mgbe ọgwụgwọ dị otú ahụ adịghị.

Achọpụtaghị nkọwapụta usoro ọgwụgwọ maka ndị ọrịa nwere ọdịda akụrụ, ebe ọrịa ndị dị otú a anaghị emetụta arụmọrụ nke atorvastatin.

Ntụziaka ahụ akọwaghị ndị ọrịa na-eji nje HIV na ọrịa ịba ọcha n'anya C, yana cyclosporine ịkọwa Torvacard.

Nyere aka ịdoụbiga mmanya ókè

Enweghị ọgwụgwọ pụrụ iche maka iji Torvacard riri oke. A na-ahọpụta usoro dabere na nrịanrịa, ejiri usoro nkwado kwado ya. N'ihi nnabata ngwa ngwa nke ihe na - akpata ọbara, mmadụ ekwesịghị ịtụ anya ka abawanye na nhichapu ya site n'ọbara.

Maka Thoracard, enwere ike ịchọta ntuziaka maka iji ya rụọ ebe a.

Nsonaazụ

Achọpụtara nsogbu dị njọ nke ọrịa na 2% nke ndị ọrịa na-asesụ usoro Torvacard dị iche iche, n'agbanyeghị ihe kpatara ya, ka edo edoro na tebụl.

Nsonaazụ	Ọ bụla dose	10 mg	20 mg	40 mg	80 mg	Ebe
Nasopharyngitis	8,3	12,9	5,3	7	4,2	8,2
Arthralgia	6,9	8,9	11,7	10,6	4,3	6,5
Ọgba aghara	6,8	7,3	6,4	14,1	5,2	6,3
Ahụ mgbu	6	8,5	3,7	9,3	3,1	5,9
Ọrịa ọnya afọ	5,7	6,9	6,4	8	4,1	5,6
Ọrịa Dyspeptik	4,7	5,9	3,2	6	3,3	4,3
Ahụ erughị ala	4	3,7	3,7	7,1	3,8	3,5
Akwara mgbu	3,8	5,2	3,2	5,1	2,3	3,6
Akwara ahu	3,6	4,6	4,8	5,1	2,4	3
Myalgia	3,5	3,6	5,9	8,4	2,7	3,1
Nsogbu ihi ụra	3	2,8	1,1	5,3	2,8	2,9
Ihe mgbu Pharyngolaryngeal	2,3	3,9	1,6	2,8	0,7	2,1

Atorvastatin anaghị emetụta oke nlebara anya na mmeghachi omume mgbe eji usoro ma ọ bụ njikwa ụgbọ njem arụ ọrụ.

Torvacard - analogues

Ọgwụ nwere ngwongwo ya nwere ike ịgụnye atorvastatin ma ọ bụ nwee ọrụ ndị yiri ya na-emetụta ahụ. Tupu ị na-ekpebi ma ị ga-agbanwe gaa na usoro ọgwụgwọ ọzọ, ị kwesịrị ịkpọtụrụ dọkịta gị mgbe niile.

Maka akụrụngwa nọ n'ọrụ, ị nwere ike ịhọrọ maka Torvakard analogues dị ọnụ ma dị ọnụ ala karịa: