Insulin Apidra Solostar: ntuziaka maka ojiji

Ihe na - arụ ọrụ: insulin glulisin - 100 PIECES (3.49 mg),
ndị mbụ: metacresol (m-cresol) 3.15 mg, trometamol (tromethamine) 6.0 mg, sodium chloride 5.0 mg, polysorbate 20 0.01 mg, sodium hydroxide ka pH 7.3, hydrochloric acid ka pH 7 3, mmiri maka ịgba ntụtụ ruo 1.0 ml.

Nkọwa Pipe mmiri na-enweghị ntụ.

Ngwá ọgwụ ọgwụ:

Mlọ ọgwụ Insulin glulisin bụ ọgwụ ana-eme ka mmadụ nwee, nke ya na ike insulin.
Ihe kachasị mkpa nke insulin na analogues insulin, gụnyere insulin glulisin, bụ usoro nke usoro glucose. Insulin na -ebelata nnabata nke glucose n’ime ọbara, na-akpali nnabata nke glucose site n’akwara anụ ahụ, ọkachasị akwara na akwara adi adi, na-egbochikwa glucose n’imeju. Insulin na - egbochi arapu lipolysis na adipocytes, na - egbochi proteolysis ma na - abawanye njikọ protein. Mmụta dị na ndị ọrụ afọ ofufo nwere ahụike na ndị ọrịa nwere ọrịa mellitus gosipụtara na site na nchịkwa insulin na-adị ala nke insulin, glulisin na-amalite ime ngwa ngwa ma na-enwe oge dị mkpirikpi karịa insulin na-arịa mmadụ. Site na nchịkwa subcutaneous, mmetụta nke insulin glulisin, nke na-ebelata oke glucose na ọbara, na-amalite mgbe nkeji 10-20 gachara. Mgbe a na-achịkwa ya n'ime intraven, mmetụta nke iwetulata mgbanye glucose na ọbara nke insulin glulisin na insulin mmadụ na -akpọ nhatanha na ike. Otu sel insulin glulisin nwere otu ọrụ hypoglycemic dị ka otu akụkụ insulin na -akpata mmadụ.
N’oge m na-adakarị ụlọ ọgwụ na ndị ọrịa nwere ụdị ọrịa shuga 1 nke ọrịa shuga, hypoglycemic profaịlụ nke insulin glulisin na insulin mmadụ na-agbanye n’otu n’arụghị ọgwụ were were ọkara 0.15 U / n'arọ n’oge dị iche iche n’ihe metụtara nri nkeji iri na ise. Nsonaazụ nke ọmụmụ gosiri na glulisin insulin, nke a na-ahụ maka nkeji 2 tupu nri, na-ewepụta otu glycemic njikwa mgbe nri dị ka insulin mmadụ na-ara, na-achịkwa nkeji iri atọ tupu nri. Mgbe a na-enye ya nkeji iri abụọ tupu nri, insulin glulisin na-ahụ maka njikwa glycemic ka mma mgbe nri gasịrị karịa insulin na -anụ mmadụ na-achịkwa nkeji 2 tupu nri. Gululisin insulin, nke enyere 15 nkeji mgbe nri bido, nyekwara otu glycemic njikwa mgbe nri dị ka insulin mmadụ nwere ike isi, na-ahụ maka nkeji 2 tupu nri.
Uzo omumu ihe omumu, mu na insulin glulisin, insulin lispro na insulin mmadu na-aru n’otu n’ime ndi ọrịa nwere oria mellitus na oke ibu gosiputara na n’ime ndi oria insulin glulisin nwere njiri mara ngwa-ngwa. N'ime ọmụmụ ihe a, oge iru 20% nke mkpokọta AUC (mpaghara n'okpuru oge nlebara anya) bụ nkeji 114 maka insulin glulisin, nkeji 121 maka insulin lispro na nkeji 150 maka insulin na -akpata mmadụ, yana AUC (awa 0-2), na-egosipụta ọzọ n'oge hypoglycemic ọrụ, otu, bụ 427 mg / kg maka insulin glulisin, 354 mg / kg maka insulin lispro, na 197 mg / n'arọ maka insulin mmadụ na -akpata.
Ọmụmụ nyocha ahụike nke ụdị 1.
N'ime ule izu 26 nke oge III, nke jiri insulin glulisin na insulin lispro, na-achịkwa subcutaneously obere oge tupu nri (nkeji 0¬15), ndị ọrịa nwere ụdị ọrịa shuga 1 nke mellitus na-eji insulin glargine dị ka basal, insulin glulisin bụ jiri ya tụnyere insulin lispro n'ihe banyere njikwa glycemic, nke ntụle nyocha gbanwere na mkpokọta gemocosylated haemoglobin (Lb1c) n'oge echiche ọmụmụ ma e jiri ya tụnyere nke mbụ. A hụrụ ọkwa glucose ọbara dị iche iche, nyocha onwe ya. Site na nchịkwa nke glulisin insulin, n'ụzọ dị iche na ọgwụgwọ insulin, lyspro achọghị mmụba n'ọtụtụ insulin basal.
Nnwale izu 12 a na-enyocha ụlọ ọgwụ III mere na ndị ọrịa nwere ụdị ọrịa shuga 1 nke natara insulin glargine dị ka ọgwụgwọ basal gosiri na ịdị irè nke nchịkwa insulin glulisin ozugbo nri riri ka nke insulin glulisin insulin ozugbo tupu nri (maka Nkeji 0-15) ma ọ bụ insulin na-arịa mmadụ (nkeji 30-45 tupu nri).
N'ime ọnụ ọgụgụ ndị ọrịa mezuru usoro ọmụmụ ihe ọmụmụ, n'ime ìgwè ndị ọrịa natara insulin glulisin tupu nri, a hụrụ nnukwu Mbelata nke HL1C ma e jiri ya tụnyere ìgwè ndị ọrịa natara insulin nke mmadụ.

Ọrịa shuga 2dị 2
A na-eme nyocha izu nke 26 nke izu III na-esochi ọmụmụ ihe nchebe izu 26 iji tụnyere insulin glulisin (minit 0-15 tupu nri) na insulin mmadụ na-ata mmiri (nkeji 30-45 tupu nri), nke E hiwere subcutaneously na ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa mellitus, na mgbakwunye na iji insulin-isofan dị ka insulin basal. Gburugburu ọnụ ọgụgụ ndị ọrịa na-arịa ọrịa dị 34.55 kg / m2 Insulin glulisin gosipụtara na ya dị ka insulin mmadụ na-arịa ya na mgbanwe maka mgbanwe nke HL1C mgbe ọnwa 6 nke ọgwụgwọ gasịrị ma e jiri ya tụnyere uru mbụ (-0.46% maka insulin glulisin na -0.30% maka insulin na -akpụ mmadụ, p = 0.0029) na mgbe ọnwa ọgwụgwọ 12 gasịrị ma e jiri ya tụnyere uru mbụ (-0.23% maka insulin glulisin na -0.13% maka insulin mmadụ na-arịa, ọdịiche ahụ abụghị ihe dị mkpa). N'ime ọmụmụ ihe a, ọtụtụ ndị ọrịa (79%) gwakọtara insulin na-adịghị adị obere na insulin-isophan ozugbo tupu ịgba ntụtụ. Ndị ọrịa 58 n'oge usoro nyocha jiri ọgwụ hypoglycemic ọnụ wee nata ndị ozi ma nata ntụziaka iji gaa n'ihu na-ewere ha otu usoro (agbanweghị).

Ọsọ na okike
N'ime nnwale ụlọ ọgwụ a na-achịkwa na ndị okenye, e gosipụtaghị ọdịiche dị na nchekwa na arụmọrụ nke glulisin insulin na nyocha nke ìgwè dị iche iche site na agbụrụ na okike.

Mlọ ọgwụ Na insulin glulisin, nnọchi nke amino acid asparagine nke insulin na-elekọta mmadụ na ọnọdụ B3 na lysine na lysine n'ọnọdụ B29 nwere glutamic acid na-akwalite mmịpụta ngwa ngwa.

Absorption na Bioavailability
Oge ntinye uche nke Pharmacokinetic na ndị ọrụ afọ ofufo nwere ahụike na ndị ọrịa nwere ụdị 1 na ụdị ọrịa shuga mellitus nke abụọ gosipụtara na nnabata insulin glulisin tụnyere insulin na -akpata mmadụ dị ihe dị ka ugboro abụọ ngwa ngwa, ihe kachasị plasma ịta ahụ (Stax) bụ ihe dịka 2 ugboro karịa.
N'ime ọmụmụ emere na ndị ọrịa nwere ụdị ọrịa shuga 1 nke mellitus, mgbe nchịkwa subcutaneous nke insulin glulisin na dose nke 0.15 U / kg, Tmax (oge mmalite nke ịta ọkwa plasma kachasị) bụ nkeji 55, na Stm bụ 82 ± 1.3 mcU / ml E jiri ya tụnyere Tmax nke nkeji 82 na Cmax nke 46 ± 1.3 μU / ml maka insulin mmadụ na -agabiga. Oge inyefe na sistemụ insulin glulisin dị mkpụmkpụ (nkeji 98) karịa ka insulin na -akpata mmadụ (nkeji 161).
N'ime omumu n'ime ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa shuga mgbe subcutaneous nchịkwa nke insulin glulisin na dose nke 0.2 U / n'arọ, Stax bụ 91 mkU / ml nwere etiti dị n'etiti 78 ruo 104 mkU / ml.
Site na nchịkwa subulinaneous insulin glulisin na mpaghara mpaghara mgbidi, apata ụkwụ, ma ọ bụ ubu (mpaghara mpaghara akwara), iwere ngwa ngwa mgbe ewebata mpaghara mpaghara oghere ihu dị ka ọ dị ma e jiri ya tụnyere nchịkwa ọgwụ na mpaghara nke apata ụkwụ. Ọnụego nnabata site na mpaghara deltoid dị n'etiti.
Nnukwu bioavailability insulin glulisin nwere mgbe nchịkwa subcutaneous dị ihe dịka 70% (73% site na mgbidi dị n’afọ, 71 site na uru akwara na 68% site na mpaghara feminin) ma nwee obere mgbanwe na ndị ọrịa dị iche iche.

Nkesa
Nkesa na mwepu nke insulin glulisin na insulin nke mmadụ nwere mgbe nchịkwa intravenị yitere, ọnụego nkesa 13 na lita 21 na ọkara ndụ nke nkeji iri na atọ na iri na asaa.

Ojiji
Mgbe nchịkwa insulin subcutaneous gasịrị, glulisin na-agbapụta ngwa ngwa karịa insulin na -akpata mmadụ, na-enwe ndụ ọkara elekere nke nkeji iri anọ na isii, ma e jiri ya tụnyere ọkara ndụ nke insulin mmadụ na-enwe nke nkeji 86. Na nyocha nke ngalaba insulin glulisin na ahụ ike mmadụ yana ndị nwere ụdị 1 na ụdị 2 nke ọrịa shuga, ihe dị ka ọkara ọkara sitere na nkeji iri atọ na asaa ruo iri asaa na ise.

Otu Ndị Ọrịa Pụrụ Iche Pụrụ Iche

Ọrịa enweghị akụrụ
N'ime omumu ihe omumu nke emere na mmadu n’enweghi otutu ihe di ya n’aru ya (imeputa ihe (CC)) 80 ml / min, 30¬50 ml / min, 1/10, ndi ozo:> 1/100, 1/1000, 1 / 10000, Na ngbakọta na ụdị ntọhapụ

Yabụ, Apidra bụ insulin na-adị mkpụmkpụ. Site n ’echiche banyere ọnọdụ nchịkọta - nke a bụ ihe edozi. Emebere ya naanị maka ịbanye subcutaneous ma doo anya kpamkpam, yana enweghị agba (na ụfọdụ, ụfọdụ ntakịrị ndò ka dị ugbu a).

Akụkụ mejupụtara ya, nke dị ugbu a na ntakịrị ihe, ka ekwesịrị ịtụle insulin akpọrọ glyzulin, nke eji mara ngwa ngwa ya na mmetụta na-adịte aka. Ndị pụrụ iche bụ:

cresol
trometamol,
chloride sodium
polysorbate na ọtụtụ ndị ọzọ, dịkwa na.

Ha niile jikọtara ọnụ n’enweghị obi abụọ ọ bụla ọgwụ pụrụ ịrịa ụdị ọrịa shuga ọ bụla: ma nke mbụ ma nke abụọ. A na-emepụta insulin insidra n'ụdị katridges pụrụ iche nke iko na-enweghị agba.

Banyere mmetụta ọgwụ ọgwụ

Kedu ka Apidra si emetụta glucose?

Insulin glulin bụ ọgwụ ana-emegharị mmadụ. Dị ka ị maara, enwere ike iji ya tụnyere ike ị nweta insulin nke mmadụ, mana ọ bụ ihe e ji amata na ọ na - amalite “ịrụ ọrụ” ọsọsọ ma nwee oge mkpughe. nke a bara ezigbo uru.

Mmetụta kachasị mkpa ma dị mkpa ọ bụghị naanị na insulin, kamakwa na analogues ya, ka a ga-atụle dịka iwu mgbe niile n'ihe banyere glucose na-ebufe. Homonụ ahụ a gosipụtara na-ebelata nnabata shuga n’ọbara, nke na-akpali iji glucose site n’enyemaka nke akwara akụkụ, dị ka ọ dị. Nke a bụ eziokwu kachasị maka akwara ọkpụkpụ na akwara adipose. Insulin Apidra na - egbochikwa glucose na imeju. Na mgbakwunye, ọ na-ewepụ usoro niile metụtara lipolysis na adipocytes, proteolysis ma na-eme ka mmekọrịta protein dịkwuo elu.

Dabere na nsonaazụ nke ọtụtụ ọmụmụ, e gosipụtara na glulisin, ịbụ isi akụrụngwa ma bụrụ onye a na-ewebata ya nkeji abụọ tupu iri nri, nwere ike inye otu njikwa glucose ahụ mgbe ị risịrị insulin ụdị mmadụ dị mma maka mmụba. Agbanyeghị, ekwesịrị inye ya minit 30 tupu nri.

Banyere usoro onunu ogwu

Ihe kachasị mkpa na usoro ị ofụ ọgwụ ọ bụla, gụnyere ọgwụ insulin, kwesịrị ịtụle iji usoro ọgwụgwọ ọ bụla. A na-atụ aro ka apidra webata obere oge (maka opekempe nke efu na nke kachasi nke minit 15) tupu ma ọ bụ ozugbo nri.

Enwere ike iji ọgwụ a jikọta ya na ndị nnọchite hypoglycemic ụfọdụ.

Etu ịhọrọ otu ọgwụ Apidra?

Ekwesịrị ịhọrọ Apulin insulin dosing algorithm n'otu n'otu n'otu oge. N'ọnọdụ nke emere na ịchọpụtara ọdịda akụrụ, mbelata mkpa nke homonụ a ga-ekwe omume.

N'ime ndị ọrịa mamịrị arụ ọrụ nke akụkụ ahụ dịka imeju, mkpa ọ dị maka mmepụta insulin na-eyikarị ka ọ ga-agbada. Nke a bụ n'ihi mbelata nke glucose neogenesis yana mbelata metabolism n'ihe gbasara insulin. Ihe ndị a niile na-akọwapụta nke ọma ma, na -adịghị mkpa, na-agbaso usoro egosipụtara, dị oke mkpa na ọgwụgwọ ọrịa shuga.

Banyere ogwu ogwu

Ekwesịrị iji ọgwụ ntụtụ eme ihe, yana infusion na-aga n'ihu. A na-atụ aro ka eme nke a naanị na obere ihe dị n'okpuru ala ma nwee abụba site na iji sistemụ mmemme pụrụ iche.

Ekwesịrị iji ụzọ ntụtụ dị n'okpuru:

Mmeghe nke insidra insidini site na iji ọgwụ na-aga n'ihu n'ime anụ ahụ ma ọ bụ abụba abụba kwesịrị ịdị na afọ. Mpaghara nke ọ bụghị naanị injections, kamakwa infusus na mpaghara ndị akọwapụtara na mbụ, ndị ọkachamara na-atụ aro ịgbakwunye ibe ha maka mmejuputa ọhụụ ọ bụla. Ihe ndị dị ka mpaghara mkpịsị ahụ, mmega ahụ, yana ọnọdụ ndị ọzọ “na-ese n’elu mmiri” nwere ike inwe mmetuta n'ọsọ nke nnabata, yana nsonaazụ a, mmalite na oke mmetụta ahụ.

Etu esi enye ntinye ara?

Lantkụnye akụkụ ahụ n'ahụ mgbidi nke mpaghara abdominal na-abụrụ ihe nkwenye nke nnabata ngwa ngwa karịa ịbanye n'akụkụ ndị ọzọ nke ahụ mmadụ. Gbalia ihu na iwu banyere ịkpachapụ anya iji ọgwụ wee banye n 'ụdị arịa ọbara.

Mgbe iwebata insulin "Apidra" a machibidoro ịhịa aka na saịtị ịgba ọgwụ. Ekwesịrị ịkụziri ndị ọrịa mamịrị n'ụzọ ziri ezi isi usoro ntụtụ. Nke a ga - abụ mkpịsị ugodi maka ọgwụgwọ dị mma 100%.

Banyere ọnọdụ nchekwa na usoro

Maka nsonaazụ kachasị na usoro iji akụkụ akụrụngwa ọ bụla, mmadụ kwesịrị icheta ọnọdụ na ndụ nchekwa. N'ihi ya, a gha echekwara katridges na sistem di iche iche n’ebe umu anaghi anabatacha, nke a bukwara ka aputa ya n’uche site na ìhè.

N'okwu a, a ga-ahụrịrị usoro nchekwa ọkụ, nke kwesịrị ịdị site na ogo abụọ ruo asatọ.

Ihe akụrụngwa ahụ agaghị ajụ oyi.

Mgbe ejiri ngwa ahia na katriiki ebido, ekwesiri ka edobe ha n’ebe umuaka anaghi anabataghi ya, ma obughi site n’azu oku, kamakwa n’anwu. N'otu oge ahụ, ihe ndị na-egosi ọnọdụ okpomọkụ ekwesịghị ịdị ihe karịrị ogo 25 nke okpomoku, ma ọ bụghị na nke a nwere ike ịkọwa maka ogo nke insidra insidra.

Maka nchebe kachasị ntụkwasị obi site na mmetụta nke ìhè, ọ dị mkpa ịchekwa ọ bụghị naanị katrized, mana ndị ọkachamara na-atụ aro ka usoro ndị dị otú a na ngwugwu nke ha, nke ejiri kaadiboodu pụrụ iche mee. Ndụ nchekwa nke akụkụ ahụ akọwara bụ afọ abụọ.

Ihe niile gbasara oge mmebi

Ndụ nchekwa nke ọgwụ dị na katriiki ma ọ bụ usoro a mgbe ejiri mmalite ya bụ izu anọ. Ọ dị mma icheta na akara nke etinyere insulin izizi dị na ngwugwu ahụ. Nke a ga - abụ nkwa ọzọ maka ọgwụgwọ maka ụdị ọrịa shuga ọ bụla.

Banyere mmetụta ndị ọzọ

Ekwesịrị ịkọpụta nsonaazụ ndị a na-eji amata insulin insulin iche iche. Nke mbu, anyi na ekwu maka ihe di otua hypoglycemia. Emebere ya n'ihi ị ofụ ọgwụ insulin bara ụba nke ukwuu, ya bụ, ndị na - agbanwe ihe karịrị ezigbo mkpa maka ya.

N'akụkụ nke ahụ ihe dị ka metabolism, hypoglycemia na-akpụ nke ukwuu. Ihe ịrịba ama nile nke okike ya ka ejiri mara na mberede: ọsụsọ na-acha oyi, mkpọtụ na ọtụtụ ihe ndị ọzọ. Ihe egwu dị na nke a bụ hypoglycemia ga-abawanye, nke a nwere ike ibute ọnwụ nke mmadụ.

Mmeghachi omume mpaghara na-ekwe omume, nke bụ:

hyperemia,
afụli,
isi itching (na ntụtụ).

Eleghị anya, na mgbakwunye na nke a, mmepe nke mmeghachi omume nfụkasị oge nke onwe, n'ọnọdụ ụfọdụ anyị na-ekwu maka urticaria ma ọ bụ ụkwara ume ọkụ. Agbanyeghị, mgbe ụfọdụ nke a adịghị eso nsogbu akpụkpọ ahụ, mana naanị ị asụ mmiri ma ọ bụ mgbaàmà anụ ahụ ndị ọzọ. N'ọnọdụ ọ bụla, obi abụọ adịghị ya na ị ga - agbanarị nsonaazụ niile ndị a gosipụtara site na isoro ntuziaka na icheta ojiji insulin dị mma dịka Apidra.

Banyere contraindications

Ekwesịrị itinye nlebara anya dị na ọgwụ ọ bụla maka ọgwụ ọ bụla. Nke a ga - abụ isi ihe ga - eme ka eziokwu ahụ dị na insulin ga - arụ ọrụ na 100%, bụrụ ezigbo ụzọ dị mma iji weghachi ma chekwa ahụ. Yabụ, contraindications na-egbochi iji "Apidra" kwesịrị ịgụnye hypoglycemia kwụsiri ike na mmụba nke uche nke insulin, gluzilin, yana akụkụ ndị ọzọ nke ọgwụ.

Womenmụ nwanyị dị ime nwere ike iji Apidra?

Site na nlekọta pụrụ iche, iji ngwa ọrụ a dị mkpa maka ụmụ nwanyị ahụ nọ n'oge ọ bụla nke ime ma ọ bụ na-enye nwa ara. Ebe ọ bụ na ụdị insulin a gosipụtara bụ ọgwụ siri ike, ọ nwere ike ibute nsogbu ọ bụghị naanị nwanyị, kamakwa nwa ebu n’afọ. Agbanyeghị, nke a dị anya site na ọnọdụ niile metụtara shuga. Na njikọ a, a na-atụ aro ka ị buru ụzọ gakwuru onye ọkachamara nke ga-egosi ike iwere ojiji nke insulin “Apidra” ma dezie usoro ịchọrọ.

Banyere ihe ngosi pụrụ iche

Na usoro iji ọgwụ ọ bụla, ọ dị mkpa ịtụle ọnụọgụ dị iche iche nke nuances dị iche iche. Iji maa atụ, eziokwu a ga-ebugharị na ntughari onye ọrịa mamịrị na ụdị insulin ọhụụ ma ọ bụ ihe ọzọ site na ihe ọzọ na-emetụta ya. Nke a bụ n'ihi eziokwu ahụ nwere ike ịdị mkpa ngwa ngwa maka nhazi nke usoro ọgwụgwọ ahụ dum.

Ojiji nke onunu ogwu nke ezughi oke nke akwara ma obu nke ikwusi ya ike, okachasi ndi mmadu nwere oria oria 1 nke obi uto, nwere ike iduba n’inwe obughi hyperglycemia, kamakwa ketoacidosis. Ndị a bụ ọnọdụ dị oke egwu dị ndụ na ndụ mmadụ.

Imeghari usoro ọgwụ insulin nwere ike ịdị mkpa ma ọ bụrụ na mgbanwe na mmegharị algorithm dị na atụmatụ moto ma ọ bụ mgbe ị na-eri nri.

Isiokwu ahụ nyere aka nke ukwuu. Echere m na ọtụtụ ndị na-arịa ọrịa a ga-enyere aka. Daalụ maka ịkọwa etu esi echekwa ọgwụ a. Dọkịta n'onwe ya dekwara ya. Edere edemede ahụ ọtụtụ nke ọma, enwere m olileanya na ọ ga-enyere m aka!

Akụkụ na-arụ ọrụ nke Apidra bụ insulin glulisin. Ọ bụ analogue nke insulin, nke a na-emepụta n’ime ahụ mmadụ, mana mkpụrụ ndụ na-agbanwe site na imegharị ahụ. Ike nke ime ihe dị n ’insulin nke mmadụ (soluble), mana, n’adịghị ka nke ikpeazụ, ihe a na - eme ngwa ngwa, oge mmetụta nke glulisin insulin dị mkpụmkpụ.

Ihe na-arụ ọrụ na-edozi mgbanwe nke ụmụ irighiri glucose, belata itinye uche ha n’arụ ọbara, na-eme ka nnabata glucose ụmụ irighiri ihe si n’akpukpu ndị dị na ngụkọta (karịakwa akwara akwara, akwara abụba). Insulin glulisin na-egbochi imepụta glucose n'imeju. Apidra na-egbochi usoro nke lipolysis n'ime sel anụ ahụ na-adị na adipose, na-akwụsị mbibi nke protein protein, na-emekwa ka usoro protein pụta.

Mgbe etinyere subcutaneously, a na-achọpụta mbelata ogo glucose na elekere 1 / 6-1 / 3 gachara. N'okpuru ọnọdụ nchịkwa intraven, ike insulin glulisin nwere ike na insulin nke mmadụ. Otu 1 nke insulin glulisin dị nha 1 ọgwụ insulin na mmadụ.

N'oge nnwale ụlọ ọgwụ, achọpụtara na nchịkwa nke Apidra 120 sekọnd tupu nri ga-enye gị ohere ịchịkwa glucose ọdịnaya ọbara n'ọgwụgwụ mgbe nri gachara. Ihe ị thisụ ọgwụ a ga - enyere gị aka ijikwa ọkwa glucose dị mma karịa iwebata insulin mmadụ ruo elekere tupu iri nri. Omume mgbe nchịkwa Apidra gafere mgbe nri bidoro dabara na insulin nke mmadụ, ewebata n’ime ahụ otu sekọnd iri abụọ tupu nri.

Na ọgwụgwọ nke oke ibu, ọmụmụ nke ihe Apidra gosipụtara na oge mmepe nke mmetụta na mpaghara ahụ nọ n'ọrụ na-ewe nkeji 114. AUC nke 0-2 awa bụ 427 mg × n'arọ.

Ofzọ nke ngwa

Ewebata ewebata Apidra ozugbo nri ma ọ bụ ihe ruru nkeji iri na ise tupu ya. A na-eji ọgwụ ahụ eme ihe n'ụkpụrụ ọgwụgwọ nke nweburu nkwadebe insulin nwere ogologo oge nke ime ihe ma ọ bụ analogues nke ọgwụ insulin na-arụ ọrụ ogologo oge. Enwere ike ijikọ Apidra na usoro ọgwụgwọ na ọgwụ hypoglycemic maka nchịkwa ọnụ. A họrọ usoro ị drugụ ọgwụ ahụ n'ọnọdụ ọ bụla n'otu n'otu.

Ọ dị mkpa iwepu dịka o kwere omume ọgwụ ga-abanye na akwa akwara. Ọzọkwa, ịnweghị ike ịhịa aka ebe a gbanyere ọgwụ ahụ. Mmanụ a .ụ ndị ọrụ ga-akuzi onye ọrịa ahụ ka esi eji ọgwụ ahụ.

Anabataghị ịgwakọta Apidra na ndị ọzọ na-agwọ ọrịa (ma e wezụga isofan-insulin mmadụ). Mgbe ị na-eji ọgwụ Apidra, nke a na-eweta ya na ngwaọrụ mgbapụta, ọ bụ ihe a na-anabataghị ịgwakọta ihe ngwọta na ọgwụ ọ bụla.

Iwu maka iji ogwu

Egbughachila azịza ya.
Ọ bụrụ na ọ dị mkpa ịgwakọta Apidra na insulin isofan-mmadụ, mgbe ahụ, a ga-ebu ụzọ ghee insulin glulisin n'ime sirinji. Echekwala ngwakọta agwakọtara ya.

Cartridges na ngwọta dị mma maka mkpịsị mkpụrụ sirinji OptiPen Pro 1.
Tupu iji ya, ịkwesịrị ịtụle ihe ngwọta dị na katalọgụ maka agba (kwesịrị kapụta ya), maka enweghị ụrọ.
Hapụ katalọl ahụ n'ime ụlọ maka minit 60-120 tupu itinye ya na mkpịsị ọsịị ede ede.
Wepu ụyọkọ ikuku na kateeti.
A naghị erepịcha chakị.
Ejila mkpịsị eji sirinji mebiri emebi.
Enwere ike iji sirinji plastik mee ihe maka inye ọgwụ ahụ. Maka nke a, a na-ewepu ihe a na-etinye na katriji jiri sirinji. A ga-akpọ syringe maka insulin 100 IU / ml.
Enwere ike iji mkpịsị ọsịsị eji ọgwụ eme ihe n'ịgwọ ọgwụ naanị n'otu onye ọrịa.

Iji katalọgụ nke usoro OptiClick (nke a bụ katọn nke nwere milimita 3 nke ihe ngwọta nke Apidra, nke etinyere n'ime akpa plastik nwere piston):

Ekwesịrị iji mkpịsị ugodi oplipe OptiClick nweta ya na akpa na pistin.
Ntụziaka maka iji mkpịpị mkpịpị OptiClick ka enyere na nkọwapụta nke ngwaọrụ a.
Bụrụ na nke enweghị mkpịsị edemede nke sirinji, enweghị ike iji ya.
Lelee sisitekwa ọkpọ tupu itinye ihe ngwọta. Enweghi ugbaya n’agha n’ime nkwadebe, ihe kwesiri idozi ya kwesiri ibu uzo n’enweghi ocha.
Wepu egosipụta na katalọgụ tupu ị na -ezi ihe ngwọta.
You gaghị enwe ike iji kadi kadi karịa jupụta.
Site na katriiki, ị nwere ike ịdọrọ ihe nrịba ahụ na sirinji rọba wee were ọgwụ ahụ.
Iji gbochie ọrịa, ọ bụ ihe a na-anabataghị iji mkpụrụ sirinji nye ọtụtụ ndị ọrịa.

Ewebata ọgwụ a site na ịchekwa obere ọgwụ dị n'okpuru ala. Nwere ike mepụta azịza Apidra n'ụdị infusion na-aga n’ihu site na iji usoro mgbapụta. A na-ewebata mmeghe ahụ na anụ arụ na - arụ ọrụ n'okpuru anụahụ.

Ebe kachasị mma maka ịgba ntụtụ bụ afọ, mpaghara, na apata ụkwụ. Ọ bụrụ na ọ dị mkpa, infusion na-aga n’ihu bụ iwebata anụ ahụ adipose n’okpuru anụ ahụ n’ime afọ. Ekwesiri imeghari ọhụụ nke Apidra ga-eme ebe ọhụrụ.

Ntinye uche nke ihe ndi n’adighi ike nwere ike idi iche site na ebe igba ogwu ahu, ihe omume ndi ahu, na onodu ndi ozo. A na-achọpụta mmịpụta ngwa ngwa nke ihe na-arụ ọrụ mgbe ọ dị ntụtụ n'ime mgbidi abdominal.

Nsonaazụ

Hypoglycemia - mmetụta kachasị achọkarị ọgwụ insulin, nke nwere ike ime ma ọ bụrụ na ejiri insulin dị ukwuu mee ihe, karịa ịchọrọ ya.

Ejiri mmeghachi omume ojoo na nyocha ụlọ ọgwụ metụtara njikwa ọgwụ ahụ edepụtara n'okpuru usoro usoro yana iji belata ihe omume. N'ịkọwa ugboro ole ihe a na-eme, a na-eji njirisi ndị a: ọtụtụ mgbe (> 10%), ọtụtụ mgbe (> 1% na 0.1% na 0.01% na

Ime na lactation

Enweghi ihe omuma zuru ezu banyere ojiji insulin glulisin n’ime ndi nwanyi di ime.

Ọmụmụ ọmụmụ preclinical ekpughere ọdịiche dị n’etiti insulin glulisin na insulin nke mmadụ na nsonaazụ ha dị n’afọ ime, n’afọ nwa ebu n’afọ, na ịmụ nwa na mmepe n’ime oge amụ nwa (lee nyocha nke Preclinical Safety T ule).

Mgbe ị na-edenye ndị inyom dị ime ọgwụ ahụ, ha kwesịrị ịkpachara anya. Ọ dị mkpa iji nlezianya nyochaa glucose.

N'oge afọ ime, ọ dị mkpa iji nwee ọnọdụ nke ịhazigharị metabolic na ndị ọrịa nwere ọrịa preexisting ma ọ bụ ọrịa afọ ime. Mkpa insulin n'ime oge nke atọ nke ime nwere ike belata, ọ na-abawanye na oge nke abụọ na nke atọ. Ozugbo amụrụ nwa, ọgwụ insulin na-agbada ngwa ngwa.

Amaghị ma insulin glulisin na-abanye na mmiri ara ara, agbanyeghị, insulin anaghị abanyekarị n'ime mmiri ara, a naghị etinye ya mmụọ mgbe nchịkwa ọnụ gasịrị.

Mụ nwanyị ndị na-enye nwa ara nwere ike ịgbanwe nhazi nke insulin na nri.

Mmetụta akụkụ

Hypoglycemia, mmeghachi omume kachasị emetụta ọgwụgwọ insulin, nwere ike ịmalite ma ọ bụrụ na ọgwụ insulin dị elu ma e jiri ya tụnyere mkpa insulin.

Mmeghachi omume ndị a na-esote iji ọgwụ ahụ, nke a hụrụ n'oge ule ụlọ ọgwụ, ka e gosipụtara n'okpuru usoro klaasị nke akụkụ ahụ na ibelata ihe omume ha (nke ukwuu:> 1/10, ugboro> 1/100, 1/1000, 1/10000,

Dodoụbiga ya ókè

Ikekwe mmepe nke hypoglycemia n'ihi nsonaazụ insulin n'ihe metụtara oriri na ọnụ ahịa ike nke onye ọrịa.

Enweghị data akọwapụtara nke ọma maka ịlụ ọgwụ insulin gabigara ókè. Agbanyeghị, hypoglycemia nwere ike ịmalite n'oge nkebi.

A nwere ike iji glucose ọnụ ma ọ bụ ihe ndị na-atọ ụtọ nye mmadụ nsogbu nke hypoglycemia. Ya mere, a na-atụ aro ka ndị na-arịa ọrịa shuga nwee obere shuga, swiiti, kuki ma ọ bụ ihe ọ fruitụ fruitụ mkpụrụ osisi dị ụtọ so ha. Ọnọdụ nke hypoglycemia siri ike, mgbe onye ọrịa dara, enwere ike ịgwọ ya na glucagon (0,5 - 1 mg), onye nyere ya nkuzi intramuscularly ma ọ bụ subcutaneously site na onye natara ntuziaka dị mkpa, ma ọ bụ mesoo ya na glucose ọbara nke ọkachamara ahụike na-elekọta. Ekwesịrị ijikwa glucose na intraven ma ọ bụrụ na enweghị nzaghachi onye ọrịa glucagon maka nkeji 10-15. Mgbe ị nwetasịrị, a na-atụ aro iri nri carbohydrate iji gbochie nlọghachi.

Mgbe agwesịrị ọgwụ glucagon, ọ dị mkpa iji lelee onye ọrịa n'ụlọ ọgwụ iji chọpụta ihe kpatara hypoglycemia dị ukwuu ma gbochie mmepe nke akụkụ dị otú ahụ n'ọdịnihu.

Mmekọrịta na ọgwụ ndị ọzọ

Enweghi omumu omumu ihe omumu banyere ogwu. Dabere na ahụmịhe ha nwetara na ọgwụ ndị ọzọ yiri ya, mmekọrịta nke ọgwụ ọgwụ nke mkpa ọgwụgwọ adabaghị.

Gwa dọkịta gị banyere ọgwụ niile ị ,ụrụ, ọ bụrụgodi na ọ bụrụ na ọ bụrụ na ọ bụrụ n'ikpe niile!

Substancesfọdụ ihe na-emetụta metabolism nke glucose, ya mere ndozi nke insulin glulisin na nlebara anya nlebara anya nwere ike ịchọ.

Ihe ndị nwere ike ịkwalite nsonaazụ glucose dị n'ọbara ma mee ka ebumnuche hypoglycemia gụnyere ọgwụ hypoglycemic nke ọgwụ, angiotensin-na-agbanwe enzyme inhibitors, na-enupụ isi, fibrates, fluoxetine, ndị na-egbochi MAO, pentoxifylline, propoxyphene, salicylates na sulfibamide.

Ihe ndị nwere ike belata ọrụ mgbatị glucose ọbara gụnyere homonụ glucocorticosteroid, danazole, diazoxide, diuretics, glucagon, isoniazid, ihe ndị sitere na phenothiazine, somatropin, sympathomimetics (dịka epinephrine adrenaline, salbutamol, terbutaline, homonụ, hormones, e.g.) , na mgbochi ogwu), ndi na - egbochi ande antiychotictic (dịka ọmụmaatụ, olanzapine na clozapine).

Ndị na-egbochi Beta-blockers, clonidine, nnu nke lithium na mmanya nwere ike ịkwalite ma mee ka ọrụ glucose ala na-ebelata ike. Pentamidine nwere ike ibute hypoglycemia, nke na-abanye hyperglycemia mgbe ụfọdụ.

Na mgbakwunye, n'okpuru nduzi nke ọgwụ ọmịiko dịka ß-blockers, clonidine, guanethidine na reserpine, ihe ịrịba ama nke antiregulation adrenergic nwere ike ịdị nro ma ọ bụ anọghị ya.

Iwu Ndakọrịta

N'ihi enweghị ọmụmụ ihe ndakọrịta, ọgwụ a agaghị agwakọta ya na ọgwụ na-abụghị insulin NPH mmadụ.

Njirimara ngwa

Ekwesịrị ịfefe onye ọrịa n'ọrịa ma ọ bụ ụdị insulin ọ bụla n'okpuru nlekọta ahụike siri ike. Mgbanwe n'ụdị ntọhapụ, akara (onye na-emepụta), ụdị (ọkọlọtọ, NPH, ihe na-adịghị ngwa, wdg), mbido (ụdị anụmanụ) yana (ma ọ bụ) teknụzụ mmepụta nwere ike ịbanye mgbanwe na usoro onunu ogwu. May nwere ike ịchọ dozie ọgwụ onodu hypoglycemic nke onụ n’otu oge iji ọgwụgwọ n’otu oge.

Ọgwụ ma ọ bụ ịkwụsịtụ ọgwụgwọ, ezughị ezu ndị ọrịa shuga na-akpata ọrịa shuga, nwere ike ibute ọrịa hyperglycemia na ketoacidosis - ọrịa na-eyi ndụ egwu.

Oge mmepe nke hypoglycemia dabere na usoro nke insulin ejiri mee ihe, yabụ, enwere ike ịgbanwe ya na mgbanwe na usoro ọgwụgwọ.

Ọnọdụ nwere ike ịgbanwe ma ọ bụ ibelata ihe mgbaàmà mbụ nke hypoglycemia gụnyere ihe ndị a: ọrịa shuga ogologo oge, nlekọta siri ike na insulin, neuropathy mamịrị, ọgwụ dịka ß-egbochi, ma ọ bụ mgbanwe site na anụmanụ gaa na insulin nke mmadụ. Enwere ike ịchọ dozigharị ma ọ bụrụ na onye ọrịa ahụ amụbaala mmega ahụ ya ma ọ bụ gbanwee usoro iri nri. Exerciseme mmega ahụ ozugbo ị risịrị nri nwere ike ịbawanye ohere nke hypoglycemia.

Ọ bụrụ na hypoglycemia bidoro mgbe ịgba ọgwụ analogs nke na - eme ngwa ngwa, mgbe ahụ ọ nwere ike ịmalite n'oge, ma e jiri ya tụnyere insulin nke insulin na-arịa mmadụ.

Ọ bụrụ na edozighị hypoglycemic na mmeghachi omume hyperglycemic, ha nwere ike ibute nsụhọ, onye na ọnwụ onye ọrịa.

Mkpa onye insulin nwere ike ịgbanwe n'oge ọrịa ma ọ bụ nchekasị.

Aka Syringe

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Mpempe mwepụta

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