Gluconorm - ọgwụ maka ụdị shuga 2

Ọgwụ ahụ dị n'ụdị mbadamba gburugburu ọcha, convex n'akụkụ abụọ. Mpempe ọgwụ na-achịkọta na paịlị mbadamba 10 nke ọ bụla. Katoonu nwere 4 blisters. Enwekwara ngwugwu nke nwere blister 2 nke mbadamba iri abụọ.

Mbadamba ọgwụ Gluconorm nwere ihe ndị na-arụ ọrụ:

• metformin hydrochloride - 400 mg,
• glibenclamide - 2,5 mg.

Iji mee ka bioavailability dịkwuo elu, ihe mejupụtara ahụ gụnyere ihe ndị na-enye aka: gelatin, glycerol, diethyl phthalate, croscarmellose sodium, ọka ọka, talc, magnesium stearate, colloidal silicon dioxide, microcrystalline cellulose.

Omume ọgwụ

Ọ bụ ngwakọta nke ọgwụ hypoglycemic sitere na otu ọgwụ ọgwụ nje dị iche iche: metformin na glibenclamide. Nke ikpeazụ ahụ na-ezo aka n'ụkpụrụ usoro nke usoro nke abụọ. Ọ na - eme ka glucose na - eme ka mkpụrụ ndụ glucose na - eme ka ọ nwee ike ịba ụba nke insulin na ọkwa nke abụọ. Na-akpali ume insulin na ọnụ ụzọ nke ya iji mebie mkpụrụ ndụ. Glibenclamide na-akwalite nnabata nke shuga site na akwara na akwara, ma n'otu oge ahụ na-egbochi mmebi nke abụba site na ume nke lipase.

Metformin sitere na otu biguanides. Ezubere iji mee ka mmadụ nwekwuo ike ma mee ka ihe ndị na-akpali glucose na -akpọ anụ ahụ. Akụrụngwa nọ n'ọrụ na-ebelata ogo lipoproteins dị ala na triglycerides, na-enwe ezigbo mmetụta na profaịlụ egbugbere ọnụ nke ọbara. Na-egbochi guzobe plasta cholesterol n'emeghị mmetụta hypoglycemic.

Glibenclamide

Mgbe nchịkwa ọnụ gachara, adsorption nke glibenclamide na obere eriri afọ bụ 50-85%. Ihe ahụ rutere n’obara ya kachasị n’ọbara mgbe awa 1.5-2 gachara. Ọ na - ejikọ protein protein plasma site na 95%.

Glibenclamide fọrọ nke nta ka ọ gbanwee kpam kpam na imeju ya na imepụta metabolites abụọ na-adịghị arụ ọrụ. Eriri iche site na akụrụ na eriri afọ. Ọkara ọkara na-anọru awa 3 ruo 16.

Mgbe ọ banye na eriri afọ, iwere ihe zuru oke na-apụta. Bioavailability ruru 50-60%. Achịcha nke ihe ahụ belatara n’otu nri. 30% nke metformin bụ nke ezi na feces. A na-ekesasị ihe ndị ọzọ ngwa ngwa n’akwara niile na-ejikọtaghị ya na protin plasma.

Ọkara ndụ bido awa 9-12. Fọrọ nke nta ka ọ ghara itinye aka na metabolism. Mwepu nke metformin n’anụ ahụ na-eme site na akụrụ.

Ndị na-arịa ụdị ọrịa shuga 2 na-eji glucose eme ihe:

• na nri nri dị ala na mmega ahụ,
• na ọdịda nke usoro ọgwụgwọ metformin gara aga na ndị nwere ọ̀tụ̀tụ̀ shuga a na-achịkwa.

Akwadoro maka iji ndị gaferela afọ 18.

Ihe ngbanwe

Amachibidoro gluconorm maka ojiji:

• Patientsdị nke ndị ọrịa shuga
• duringmụ nwanyị n’oge ime na na-enye ara,
• na otu ọgwụ miconazole,
• n'ihu ọnụnọ oke nke akụrụngwa
• ndi nwere shuga di ala
• ndị ọrịa na-efe efe nke ọrịa na-efe efe,
• na mgbe ịwa ahụ n'oge ịwa ahụ iji wepu ọkụ nke nnukwu mpaghara,
• yana ọrịa imeju na akụrụ, yana ọnọdụ ndị na - eduga na ha (imebi nguzozi mmiri - nnu, oke ike ọgwụgwụ, nsogbu nke myocardial na pulmonary ọdịda),
• na-egbu ahu aru.
• ụbọchi abụọ tupu na mgbe a na-ese foto site na iji ihe dị iche, nke gụnyere ayodiin,
• ya na lactic acidosis,
• dabere na obere kalori, nke mmadụ riri ihe na-erughị 1000 kcal / ụbọchị,
• na ọnụnọ nke ihe nfụkasị mejupụtara metformin na ngwa inyeaka.

A na-atụkwa anya ka akpachara anya na ahụ ọkụ, nsị na atrophy nke grenal adrenal, ọ bụrụ na ọ nwere arụ ọrụ nke azụ mgbu na akwara gland.

Ntụziaka maka ojiji (usoro)

Gluconorm ezubere maka nchịkwa ọnụ. A na-ahọpụta usoro ị theụ ọgwụ ahụ n'otu n'otu site na dọkịta na-aga ya. Ndabere maka nhọpụta kwa ụbọchị bụ nsonaazụ nyocha.

Na mbido ọgwụgwọ ọgwụ, a na-edenye onye ọrịa 1 mbadamba ọgwụ kwa ụbọchị. Mgbe mkpụrụ ụbọchị asaa na asaa gachara, a na-edozi ọ̀gwụ nke ọgwụ ahụ dabere na nyocha nke ọkwa glucose dị n'ọbara. Oke kachasị ekwesịghị ịfe mbadamba ise kwa ụbọchị.

N'ihe banyere nnọchi nke ngwakọta mbu gara aga nke metformin na glibenclamide, a na-enye onye ọrịa 1-2 mbadamba nke Gluconorm, dabere na usoro nke ọ bụla.

Nsonaazụ

Site n'akụkụ nke carbohydrate metabolism, n'ọnọdụ ndị dị ụkọ, hypoglycemia na-amalite.

Site na nsonaazụ na eriri afọ na akwara, onye ọrịa ahụ nwere ike ịnwe ọgbụgbọ, ọgbụgbọ, mgbu na mpaghara epigastric, enweghị agụụ, ụtọ "ọla" n'ọnụ. N'ọnọdụ ndị na-adịghị ahụkebe, a na-egosipụta jaundice, ọrụ nke enzymes imeju na-abawanye, ịba ọcha n'anya.

Leukopenia, thrombocytopenia, erythrocytopenia, agranulocytosis, hemolytic ma ọ bụ megaloblastic anaemia, pancytopenia na-etolite mgbe a gosipụtara mmetụta ndị sitere na sistemu hematopoietic.

Sistemụ akwara na-enwe ike imeghari isi ọwụwa, isi ike, adịghị ike, na ike ọgwụgwụ. N'ọnọdụ ndị a na-adịghị ahụkebe, a na-achọpụta paresis, ọrịa uche.

A na-egosipụta ihe nfụkasị n'ụdị mmeghachi omume akpụkpọ anụ:

• urticaria
• erythema
• akpụkpọ anụ?
• ahụ ọkụ
• arthralgia,
• proteinuria.

Site n'akụkụ nke metabolism, enwere ike lactic acidosis.

Ndị ọzọ: mmeghachi omume dị ukwuu nke mmanya na-egbu egbu mgbe mmanya gasịrị, gosipụtara site na nsogbu nke akụkụ ahụ na akụkụ iku ume (disulfiram-like mmeghachi omume: vomiting, sensations nke okpomọkụ na ihu na elu ahu, tachycardia, dizzness, isi ọwụwa).

Dodoụbiga ya ókè

An overụbiga ọgwụ ókè, mgbaàmà ndị a na-apụta n'usoro:

• agụụ
• ịba ụba,
• obi palp,
• Aka na ụkwụ,
• ụjọ na nkụda mmụọ
• isi ọwụwa
• ehighi ura
• mgbakasị ahụ
• onyonyo, ọrụ nlere anya na ọrụ ya.

Ọ bụrụ na onye ọrịa maara, a chọrọ shuga. Na ọnọdụ amaghị, 1-2 glucagon ma ọ bụ dextrose intravenous intrais kwesịrị ka a ga-elekọta. Mgbe ị na-eweghachi mmụọ doro anya, onye ọrịa ahụ ga-a foodụ nri nke nwere carbohydrates digestible.

N'ihi ọnụnọ nke metformin na "Gluconorm", onye ọrịa nwere ike ịmalite ụdị lactic acidosis. Ọnọdụ a chọrọ nlekọta ahụike mberede na ọgwụgwọ ọrịa site na hemodialysis.

Mkparịta ụka ọgwụ ọjọọ

Kpachara anya ihe nwere ike:

• allopurinol,
• ọgwụ hypoglycemic ndị ọzọ (ìgwè biguanide, insulin, acarbose),
• ihe mgbochi calcium tubule,
• ndị na-egbochi monoamine oxidase
• coumarin anticoagulants,
• salicylates,
• anabolic steroid
• enwekwuru sulfonamides,
• cyclophosphamide,
• tetracycline
• fenfluramine,
• fluoxetine
• pyridoxine
• guanethidine,
• pentoxifylline
• Ihe mgbochi ACE (enalapril, captopril),
• histamine H2 na-egbochi ihe mgbochi (cimetidine),
• antifungal (miconazole, fluconazole) na ọgwụ mgbochi TB,
• chloramphenicol.

Glucocorticosteroids, barbiturates, antiepileptics (phenytoin), acetazolamide, thiazides, chlorthalidone, furosemide, triamterene, asparaginase, baclofen, danazol, diazoxide, isoniazid, morphine, ritodrine, salbutamol, terbutaline, glucagon, rifampicin, thyroid homonụ, lithium salts ike mee ka mmetụta nke ọgwụ gharazie isi ike.

Ihe mgbochi, nicotinic acid, estrogens na chlorpromazine na-ebelata mmetụta nke ọgwụ ahụ.

N'iburu n'uche mbelata nke dissociation na ụba reabsorption nke glibenclamide, ammonium chloride, calcium chloride, ascorbic acid (na oke onunu ogwu) kwalite ihe nke ọgwụ.

"Furosemide" na-abawanye mkpokọta kachasị nke metformin site na 22%. "Nifedipine" na - akwalite mmịcha, mana mgbanye ya kachasị na-ebelata mkpọtụ nke ihe ndị na - arụ ọrụ.

Amyloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren na vancomycin sitere na usoro cationic ọgụ maka usoro ụgbọ njem tubular, site n'iji ogologo oge na-eme ka mkpokọ nke metformin dị 60%.

Ntụziaka pụrụ iche

Mkpochi ọgwụ na dochie ọgwụ insulin ọ bụrụ na ike gwụsịrị ya mgbe arụchara ọrụ ahụ, mmerụ ahụ, ọkụ nke mpaghara buru ibu, yana ọrịa nke anụ ahụ, yana oke ọkụ.

N'oge ọgwụgwọ, achọrọ ilekọta glucose oge niile.

Site na ibu ọnụ ogologo oge, yana ị alcoholụ mmanya, ohere nke ịdalata ogo glucose ọbara na-abawanye. Dabere na nyocha, n'oge ọgwụgwọ, a naghị anabata mmanya. Site na ị physicalụ ọgwụ gabigara ókè na nke mmetụta uche, a na-edozi ọgwụ nke ọgwụ ahụ, nri na-agbanwe.

Daysbọchị abụọ tupu usoro ịwa ahụ ma ọ bụ nchịkwa nchịkwa nke iodine nwere ihe dị iche achọrọ maka foto, a na-akagbu ọgwụ ahụ. Bidoghachi ka awa 48 gachara ọmụmụ ihe a.

N’oge ọgwụgwọ, ọ dị mkpa izere ihe omume dị iche iche chọrọ ịta ahụhụ na ụba ọsọ nke mmeghachi omume moto. A naghị akwado ịkwọ ụgbọala.

Ime na lactation

Amachibidoro ọgwụ a maka iji n’oge afọ ime. N’oge ichoro ya na icho ya, akagbuola ya. Gluconorm nọchiri ọgwụ insulin.

Prohibitedmụ nwanyị nọ n’oge a na-amachibido ị theụ ọgwụ ahụ n’ihi nbanye nke metformin n’ime mmiri ara. Ndi nne choro igbanwe na oria insulin. Ọ bụrụ na usoro a agaghị ekwe omume, kwụsị inye ara.

Tụnyere ihe analogues

IKWU! Amachibidoro ya iwu iji ọgwụ ndị ọzọ dochie anya Gluconorm na enweghị ọgwụ.

1. Glibomet. Nwere ihe ndi ozo di ndu: metformin na glibenclamide. Mgbe ị na-a theụ ọgwụ, mkpụrụ ndụ nke pancreas na-abawanye ma nwekwaa ike n ’ime ihe nke insulin na-abawanye.

Mana n'adịghị ka Guluconorm, ihe ngosi maka ojiji dịgasị iche:

• A na - eji "Glibomet" mee ihe mgbe anụ ahụ na - eguzogide ọgwụ ndị sitere na sulfonylurea n'ihi ogologo oge,
• ya na oria di ka insulin.

Oge ọgwụgwọ na ọnụego kwa ụbọchị nke Glibomet na-adabere ọ bụghị nanị na ịka glucose n'ọbara, kamakwa na steeti metabolism metabolism nke onye ọrịa.

Ihe dị iche na-egosikwa onwe ya na ụfọdụ mmetụta:

• Mbelata nke sel ọbara na-acha ọcha,
• Mmeghachi omume nfụkasị ahụ na-egosipụta dịka mmeghachi omume anụ ahụ (itching, redness),
• A na-ahọrọ usoro onunu ogwu kacha mma site na nyocha onye ọrịa mgbe niile.

Ọnụ ego ahụ dị 90-100 rubles dị elu.

Metglib. Ihe mejuputara isi dicha ya. Ihe di iche di na ihe ndi mere eme, nke na-akpalite igbu oge na nnabata glucose na obere eriri afọ, ma na - egbochi gluconeogenesis na glycogenolysis na imeju.

“Metglib” na –ebelata oke ahụ n'ahụ onye ọrịa site na igbochi nguzobe cholesterol na obere lipoproteins. Amachibidoro ị withụ ọgwụ ahụ na Bozentan n'ihi ọghọm nke mmịnye akwara.

Ọnụ ego ahụ adịghị ala ala karịa Gluconorm.

Pharmacodynamics na pharmacokinetics

Gluconorm nwere ngwongwo abụọ hypoglycemic nke nwere otu ọgwụ ọgwụ dị iche iche: metforminna glibenclamide.

N'otu oge, metformin bụ biguanide nke nwere ike belata ogo glucose yana ihe mejupụtara ọbara. ọbara. A na-eme nke a site na ịbawanye ụba nke uru ahụ na-eme ka insulin rụọ ọrụ yana ịkwalite njide glucose. Ọzọkwa, mwepu nke carbohydrates site na nri digestive na-ebelata ma gbochie ya gluconeogenesis na imeju. Nsonaazụ bara uru nke ọgwụ a, nke ebum n’uzọ ọnọdụ ọbara nwere, bụ ndị na-egosi izugbe cholesterol natriglycerides. Mmeghachi omume hypoglycemic adịghị etolite.

Glibenclamide bụ usoro nke abụọ sitere na usoro sulfonylurea. Ihe eji eme ka amamịghe nke insulin n'ihi mbelata nke mkpasu iwe nke sel glucose na pancreas, mmetụta nke insulin na-abawanye, yana ogo nke njikọ ya na mkpụrụ ndụ ndị chọrọ. Na mgbakwunye, mwepụta insulin na-abawanye, mmetụta nke insulin na nnabata nke glucose site na anụ ahụ akwara ma na-eme ka imeju sikwuo ike, a na-egbochi lipolysis na anụ ahụ adipose. Ihe omume a gosiputara na ogbo nke abuo insulin

A na-etinye ọgwụ ahụ nke ọma na ngọngọ nri. A na-enweta ntinye uche kachasị n'ime awa 1.5. N'ihi ya metabolism ọtụtụ metabolites. A napụrụ ọgwụ ahụ n'ahụ site na enyemaka nke akụrụ na eriri afọ.

Ihe ngosi maka ojiji

Edere ngwa Gluconorm maka ụdị ọrịa shuga 2 maka ndị ọrịa nwere okenye:

• ọgwụgwọ nri, arụ ọrụ anụ ahụ na ọgwụgwọ gara aga na glibenclamide ma ọ bụ metformin,
• mkpa iji dochie usoro ọgwụgwọ gara aga na ọgwụ a maka ndị ọrịa nwere ọgụgụ glucose ọbara ma na-achịkwa nke ọma.

Mwepụta wepụtara ya na ihe mejupụtara

Mpempe usoro onunu ogwu - mbadamba ihe eji eme ihe nkiri: okirikiri, convex n’akụkụ abụọ, ihe fọrọ nke nta ka ọ bụrụ ọcha ma ọ bụ na-acha ọcha, na mgbaji - si na-acha ọcha na-acha ọcha-acha dị na agba (kọọpu iri na pensụl, 4 blisters na igbe kaadi. , Ọnya abụọ na mkpọchi kaadiboodu).

Ihe dị n'ime 1 mbadamba:

• metformin hydrochloride - 400 mg,
• glibenclamide - 2,5 mg.

Ihe ndi ozo: diethyl phthalate, sodium croscarmellose, glycerol, gelatin, stachi ọka, cellulosefate, talc nke di ọcha, colloidal silicon dioxide, sodium carboxymethyl stachi, microcrystalline cellulose, magnesium stearate.

Nsonaazụ

Mgbe ị na-ewere Gluconorm, mmetụta ndị ọzọ nwere ike ịmalite nke na-emetụta metabolism metabolism, imeju na eriri afọ, hematopoiesis na sistem ụjọ. Enwere ike ibute nke a: hypoglycemia, lactic acidosis, ọgbụgbọ, ọgbụgbọ, mgbu afọ, ọnwụ agụụ, leukopenia, thrombocytopenia, erythrocytopenia, isi ọwụwa, dizzinessadịghị ike, ike ọgwụgwụ na ihe ndị ọzọ.

Gluconorm, ntuziaka maka ojiji (Usoro na usoro onunu ogwu)

Emere ọgwụ a maka nchịkwa ọnụ n'otu oge nri. N'okwu a, dọkịta kpebiri ịsụ ọgwụ ahụ, na-eburu n'uche njirimara onye ọrịa ọ bụla dabere na ngosipụta nke glucose ọbara.

Dịka iwu, usoro ọgwụgwọ na-amalite site na usoro ị ga - eji eme ya kwa ụbọchị - 1 mbadamba. Kwa izu abụọ, a na-agbanwe dose ahụ dabere na glucose dị n'ọbara. Mgbe emechara usoro ọgwụgwọ gara aga na metformin na glybeklamide, a na-enye ndị ọrịa ọgwụ mbadamba 1-2. Na nke a, usoro ị ga-eme kwa ụbọchị nwere ike ịbụ karịa mbadamba ise.

Ihe ngosi maka nhọpụta nke gluconorm

N'ọtụtụ ndị ọrịa nwere ọrịa mellitus, otu ọgwụ enweghị ike idozi glucose n'ụzọ nkịtị, yabụ ndị dọkịta na-ejikarị ọgwụgwọ agbakọta. Ihe ngosi maka nhọpụta ya bụ gemoclobin glycated dị elu karịa 6.5-7%.Ihe kachasị dị iche iche na-atụle njikọta nke metformin yana usoro sulfonylurea (PSM), gliptins na incretin mimetics. Njikọ ndị a niile na-emetụta ma nkwụghachi insulin na olu mmepụta insulin ozugbo, yabụ ha na-enye nsonaazụ kachasị mma.

Nchikota nke metformin + sulfonylurea bu ihe kariri. Ihe n’enweghi ike imekorita ibe ha, emela ka odi ndu. Glibenclamide bụ ihe kachasị ike ma mụọ gbasara PSM niile. O nwere ọnụahịa dị ala ma na-ere ya na ahịa ọgwụ niile, yabụ, na njikọta metformin, glibenclamide ka edepụtara ọtụtụ oge karịa ọgwụ ndị ọzọ. Maka ịdị mfe iji, etinyere mbadamba ihe abụọ nwere ihe abụọ a na - arụ ọrụ - Gluconorm na analogues ya.

Dịka ntuziaka ahụ si dị, a na-eji Gluconorm naanị maka ụdị shuga 2, ọ bụrụ na nrụzi nri, egwuregwu, na metformin enyeghị ọdịda glucose iji mepụta ụkpụrụ. Ogwu metformin kwesịrị ịbụ nke kachasị mma (2000 mg) ma ọ bụ onye ọrịa mamịrị na-anabata. Ọzọkwa, enwere ike ibute gluconorm site na ndị ọrịa na-a previouslyụbu glibenclamide na mbụ na metformin iche.

Nchoputa emere: obere mbadamba nkume onye ọrịa na-ewere kwa ụbọchị, ka ọ na-enwekwu mmasị ịgbaso usoro ọgwụ niile dọkịta, nke pụtara na mmụba dị elu nke ọgwụgwọ. Nke ahụ bụ, were Gluconorm kama mbadamba mbadamba abụọ bụ obere nzọụkwụ maka ụgwọ kachasị mma maka ọrịa shuga.

Na mgbakwunye, ịrị elu okpukpu abụọ nke usoro mbadamba shuga na-ebelata shuga adịghị enye mbelata otu shuga. Nke ahụ bụ, ọgwụ abụọ n'ime obere obere ga-arụ ọrụ karịa nke ọma ma nye nsonaazụ dị ala karịa otu ọgwụ na oke usoro.

Ngwakọta na mmetụta nke ọgwụ ahụ

A na-emepụta Gluconorm site na ụlọ ọrụ Russia Pharmstandard na mmekorita ya na Indian Biopharm. Ọgwụ dị na nsụgharị 2:

1. A na-eme mbadamba gluconorm na India, nke ejiri ya na Russia. Ogwu ahu nwere usoro ogwu akpukpo aru nke 2.5-400, ya bu, okpokoro nke metformin obula nwere 400 mg, glibenclamide 2.5 mg.
2. A na-emepụta mbadamba Gluconorm Plus na Russia site na ọgwụ ọgwụ zụrụ na India na China. Ha nwere usoro onunu ogwu 2: 2.5-500 maka ndị ọrịa mamịrị nke nwere nnukwu insulin na-eguzogide ọgwụ na 5-500 maka ndị ọrịa na-enweghị oke ibu, mana nwere oke insulin doro anya.

Ekele dị iche iche maka usoro ị ga-esi mee ya, ị nwere ike ịhọrọ oke ziri ezi maka onye ọrịa ọ bụla nwere ụdị shuga 2.

Ka anyị tulee n ’ụzọ zuru ezu otu akụkụ nke ọgwụ Gluconorm si arụ ọrụ. Metformin na-ebelata ma postprandial na ngwa ngwa glycemia bụ nke kachasị n'ihi mbelata nguzogide insulin. Glucose na-ahapụ arịa ka ngwa ngwa, ebe ọ bụ na anụ ahụ nke insulin na-abawanye. Metformin na --ebekwa usoro glucose dị n’ahụ n’ime ihe ndị na - eme mkpụkọ ahụ, na - eme ka ọ banye n’ime ọbara site na ngụgụ nri.

Maka ndị na-arịa ọrịa shuga, akụrụngwa ndị ọzọ nke metformin na-ejikọghị na mbelata glycemia dịkwa ezigbo mkpa. Ọgwụ na-egbochi mmepe nke angiopathy site na ịhazi mkpụrụ ndụ ọbara, na-eme ka anụ ahụ dị mma. Dabere na akụkọ ụfọdụ, metformin nwere ike igbochi ọdịdị neoplasms. Dị ka ndị ọrịa si kwuo, ọ na -ebelata agụụ, na-enyere aka ịnọgide na-enwe oke ibu, na-akpali ibu ibu, na-amụba ịdị irè nke nri.

Glibenclamide bụ ọgbọ PSM. Ọ na - eme ihe na sel beta pancreatic: ọ na - ebelata etu ụzọ ha si elebara ọkwa glucose ọbara, si otú a na - abawanye mmepụta insulin. Glibenclamide na - akwalitekwa glycogenogenesis - usoro ịchekwa glucose na akwara na umeji. N'adịghị ka metformin, ọgwụ a nwere ike ibute hypoglycemia, dị njọ karịa ndị nnọchianya ndị ọzọ nke otu PSM - glimepiride na glyclazide. A na-ewere Glibenclamide dị ka onye kachasị ike, kamakwa ọ kachasị dị ize ndụ nke PSM. A naghị akwado ya maka ndị ọrịa mamịrị nwere nnukwu ọrịa hypoglycemia.

Etu ị ga-esi nweta ọgwụ Gluconorm

Ihe kachasị emetụta metformin bụ mgbaze, glibenclamide - hypoglycemia. Nwere ike belata ihe egwu nke nsonaazụ na-adịghị mma nke ọgwụgwọ na gluconorm, were ọgwụ n’otu oge nri ma jiri nwayọ na-abawanye ọgwụ, na-amalite site na nke kacha nta.

Usoro onunu ogwu nke Gluconorm dika ntuziaka ndi a si di:

Site na nguzogide insulin siri ike, nke bu ihe e ji mara ndi buru oke ibu, enwere ike inye ha ọgwụ ndi ozo. Ọtụtụ mgbe na nke a, ha na-a itụ ya tupu ị lakpuo ụra. A na-ewere oke kachasị mma kwa ụbọchị nke metformin dịka 2000 mg, nke kachasị - 3000 mg. Mmụba na-abawanye na usoro usoro ọgwụgwọ dị ize ndụ na lactic acidosis.

Ebe enweghi carbohydrates na nri, Gluconorm na-ebute hypoglycemia. Iji gbochie ya, achịcha ndị dị mbadamba mmanya na-egbu egbu. Ngwaahịa ga-enwerịrị carbohydrates, ọkachasị nwayọ. Gaghị ekwe ka ogologo oge dị n'etiti nri, yabụ a na-atụ aro ndị ọrịa karịa nri pụrụ iche. Nyocha nke ndị ọrịa mamịrị na-egosi na n’ịgba mbọ anụ ahụ, shuga nwere ike daa n’ime nkeji. N'oge a, ị ga - elebara ahụike gị anya.

Analogs na nnọchi

Analogues zuru oke, yana metformin na glibenclamide dị iche iche, nwere ike ị drunkụbiga mmanya oke na otu usoro gluconorm. Ọ bụrụ n’inwe atụmatụ ịgbanwere usoro ọgwụgwọ ọzọ, Ọ ga-ahọrọ nke ọzọ. Ndị dọkịta na-atụ aro ka ịgbanwee site na Gluconorm gaa Amaryl ma ọ bụ Glimecomb maka ndị ọrịa mamịrị nwere ụdị carbohydrate ụdị 2, nke na-enwekarị hypoglycemia.

Dabere na nyocha, arụmọrụ nke Gluconorm na analogues dị nso, mana ndị na-arịa ọrịa shuga ka na-ahọrọ Glybomet nke German, na-atụle ya ọgwụ kachasị mma.

Iwu nchekwa na ọnụahịa

Gluconorm dị irè ruo afọ 3 site na ụbọchị emepụtara. Anabatara Gluconorm Plus ịhapụ ihe karịrị afọ 2. Ntụziaka ahụ enweghị ihe ndị pụrụ iche maka ọnọdụ nchekwa, o zuru ezu iji lelee usoro ikuku nke anaghị elu karịa ogo 25.

Ndị ọrịa shuga na Russia nwere ike ịnweta ọgwụ abụọ dị ka ọgwụ onye isi dọkịta ma ọ bụ endocrinologist si debere n’efu. Purchasezụta nkeonwe ga-efu ọnụ ala: ọnụahịa nke otu mbadamba 40 nke Gluconorm bụ ihe dị ka 230 rubles, ọnụ ahịa Gluconorm Plus sitere na 155 ruo 215 rubles. maka mbadamba 30. Maka ntụle, ọnụahịa nke Glibomet mbụ bụ ihe dịka 320 rubles.

Gbalia imuta! You chere na nchịkwa ọgwụ ogologo oge na ọgwụ bụ naanị ụzọ eji egbochi shuga? Ọ bụghị eziokwu! Nwere ike ịchọpụta nke a n'onwe gị site na ịmalite iji ya. gụkwuo >>

Njirimara ngwa

Ọ dị mkpa ịkagbu ọgwụgwọ na ọgwụ maka ọrịa na-efe efe na-efe efe, na mmerụ ahụ buru ibu na ịwa ahụ. Ihe ọghọm nke belata ịta shuga n’oge agụụ, ihe NSAIDs, ethanol na-aba ụba. A na-eme mmezi usoro onunu mgbe a na-agbanwe nri, ike omumu na ike nke ume.

Ntụziaka Gluconorm na-akọwa na a naghị akwado ị toụ mmanya n'oge ọgwụgwọ. Illsgwọ ọgwụ nwere ike imetụta ọsọ nke ihe omume psychomotor ma belata itinye uche. Ya mere, ị ga-akpachara anya mgbe ị na-anya ụgbọ ala na-adịghị mma.

Amachibidoro ịillsụ ọgwụ n’oge nwata, n’oge afọ ime, n’oge a na-a breastụ ara, n’ihi na ihe ndị bụ isi na-abanye na mmiri ara nne. A machibidoro ọgwụ a n'ime ndị mmadụ ọrịa nje akụrụ na imeju. A naghị akwado iji mbadamba ihe n'ime ndị agadi yana mgbakwunye na mgbatị anụ ahụ siri ike.

Mmekọrịta na ọgwụ ndị ọzọ

Tupu ịmalite usoro ọgwụgwọ, ịkwesịrị ịmụ banyere otú Gluconorm si emekọrịta ọgwụ na ọgwụ ndị ọzọ:

• kwalite akụ hypoglycemic: ACE inhibitors, MAO, NSAIDs, fibrates, allopurinol, steroid anabolic, ọgwụ mgbochi-TB, mbadamba acid acid,
• mee ka mmetụta ahụ kwụsịlata: mgbochi nke homonụ, iodine nwere thyroid homonụ, barbiturates, adrenostimulants, corticosteroids, oke nke nicotinic acid, glucagon, furosemide, thiazide diuretics, ọgwụ antiepileptik,
• mụbaa metformin: ọgwụ cationic, furosemide,
• na-eto eto furosemide: metformin,
• kpochapu kpochapu nke metformin: nifedipine.

Usoro onunu ogwu na nhazi

Egosiputa gluconorm maka iji ya mee ihe. E kwesịrị iji nri dị mbadamba.

A na-ahọrọ onye zuru oke maka onye ọrịa ọ bụla dabere na data gbasara ọkwa glucose dị n'ọbara.

Ihe izizi a na-abụkarị mbadamba mbido 1 kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, mụbaa ọgwụ ahụ kwa izu 1-2 ruo mgbe a ga-enweta nsonaazụ achọrọ.

N'ihe banyere nchịkwa nke Gluconorm kama ngwakọta ọgwụ abụọ - metformin na glibenclamide - a na-ekpebi ọgwụ ahụ dabere na usoro dị iche iche nke akụkụ nke ọ bụla, a na-edenye mbadamba 1-2.

Ogo ị kacha anabata bụ mbadamba ise kwa ụbọchị.

Ozi izugbe, ihe mejupụtara na ụdị ịtọhapụ

Gluconorm bụ ọgwụ ọgwụ hypoglycemic emepụtara na India. Na mgbakwunye na mmetụta shuga dị ala, ọgwụ na-enyere aka belata mkpokọta cholesterol n'ime ọbara onye ọrịa.

A na-ahapụ ya inyefe ego ego dị ka ọgwụ nke ndị ọkachamara na-esite na ya si dị. A na-eji ọgwụ ahụ eme ihe maka afọ 3 site na ụbọchị nke emepụtara ya.

Ọ dị mkpa iji lelee ọnọdụ nchekwa ọgwụ a. A na-echekwa ya n'ebe gbara ọchịchịrị na - enweghị ụmụaka ịnweta ya. Ọnọdụ nchekwa kachasị mma bụ 20-23 0 C.

Na mgbakwunye, a na-emepụta Gluconorm nke nwere mkpụrụ osisi breeki n'ụdị tii herbal, nke abụghị ọgwụ, kama a na-ewere ya dị ka ihe ọ -ụ sugarụ shuga.

N'ime ihe ndị ọzọ dị na ọgwụ ahụ, stodi sodium carboxymethyl, magnesium stearate na cellacephate. N'ọtụtụ ebe, ọgwụ talc na stachi ọka na gelatin dị na nhazi nke ọgwụ.

Otu mkpọ mbadamba nwere blister 1-4. N'ime ọnya nwere ike ịbụ mbadamba ọgwụ ọgwụ 10, 20, 30. Mbadamba ọgwụ a na-acha ọcha ma nwee ọdịdị biconvex. N'oge ezumike, mbadamba nkume ahụ nwere ike ịnwe obere isi awọ.

Gluconorm blueberry tii nwere ihe ndị dị n’ime mbadamba ụrọ. A na-eme ya site na mkpịsị ahịhịa sitere n'okike wee resị ya n'ụdị akpa tii. Ezubere usoro mbanye ahụ izu atọ.

Pharmacology na pharmacokinetics

Gluconorm nwere ihe abụọ dị mkpa: Glibenclamide na Metformin. Ihe abuo a na - eme na nchikota jikọtara ọnụ, na - abawanye ịdị irè nke ọgwụ.

Glibenclamide bụ usoro nke abụọ sitere na usoro sulfonylurea. N'ihi ọrụ ya, a na-akpali insulin n'ahụ, ọ na-enwe ike nnweta insulin n'ụzọ dị ukwuu na mkpụrụ ndụ ebumnuche.

Glibenclamide na-akwalite mwepụta insulin na-arụ ọrụ ma na-akwalite mmetụta ya na nnabata glucose site na imeju, yana uru ahụ. N'okpuru ihe eji eme ihe, usoro nke kewara abụba na anụ ahụ adipose na-akwụsịlata.

Metformin bụ ihe biguanide. N'ihi ihe ọ na-eme, a na-ebelata mkpụkọ glucose na ọbara onye ọrịa, ọnụọgụ okirikiri na-ejide glucose.

Ihe a na - eme ka ịbelata cholesterol n'ime ọbara. N'ihi ọrụ Metformin, ịmịkọrọ carbohydrates na afọ na eriri afọ na-ebelata. Ihe dị na ahụ na - egbochi mgbochi glucose n'ime imeju.

Glibenclamide na Metformin, nke bụ akụkụ nke ọgwụ ahụ, nwere ọgwụ ọgwụ dị iche iche.

Ntinye nke glibenclamide mgbe amachara site na afọ na eriri afọ ruru 84%. Oke ịta nke mmewere nwere ike iru na otu elekere ma ọ bụ abụọ. Ihe a na-emekọrịta ihe nke ọma na protein protein. Ọnụego ya bụ 95%. Ọkara dịkarịa ala ọkara bụ 3 awa, kacha kacha bụ awa iri na isii. Ihe akụrụ ahụ dọbara akụkụ ahụ akụkụ ya ụfọdụ, eriri afọ ya.

Otutu bioavailability nke Metformin abụghị ihe karịrị 60%. Iri nri na –ebelata ike nke metformin. Ihe a na -eme n’afọ efu ka ị na-etinye afọ n’afọ na afọ.

N'adịghị ka Glibenclamide, ọ nwere njikọ dị ala na protein protein. Ọ bụ ya mere akụrụ. 30% nke ihe nwere ike ịnọ na feces nke onye ọrịa. Iwepu ọkara ndụ na-ewe awa iri na abụọ.

Ihe ngosi na contraindications

Isi ihe na-egosi ị takingụ ọgwụ a bụ ọnụnọ nke ọrịa shuga II na onye ọrịa. Ọzọkwa, edere ọgwụ ahụ na enweghị mmetụta dị mma nke ọgwụgwọ na nri, mmega ahụ na ọgwụgwọ dabere na ị takingụ Metformin na Glibenclamide.

Emekwara ka ọgwụ a pụta ìhè maka ndị ọrịa nwere shuga dị n'ọbara nkịtị ma kwụsie ike, mana ndị nwere mkpa iji dochie Glibenclamide na Metformin.

Ọnụ ọgụgụ dị ukwuu nke contraindications bụ njirimara ọgwụ:

• imeju imeju
• ọbara shuga dị ala (hypoglycemia),
• mmetụta dị elu na akụkụ nke ọgwụ ahụ,
• ụdị m ọrịa shuga
• egbu egbu egbu,
• tụụrụ ime
• arụ ọrụ na-arụ ọrụ nke akụrụngwa n'ihi ọrịa, ujo,
• ketoacidosis
• ihe miconazole,
• ọnụnọ nke oku na ahụ,
• obi obara
• inye ara
• ọrịa dị iche iche
• ọrịa mamịrị
• gbasara akwara
• infarction myocardial
• ihe ogwugwo
• lactic acidosis,
• egbu egbu egbu
• okuku ume iku ume
• precca ọrịa mamịrị
• Ọrịa porphyrin.

Ndị Ọrịa na Nduzi Pụrụ Iche

Amachibidoro ọgwụ a maka ụmụ nwanyị dị ime. Ọ bụ ihe anakwereghị ị takeụ ọgwụ ahụ n'oge ị na-eme atụmatụ ịtụrụ ime.

Ekwesịrị ka a glyconorm site na ịrara ụmụ nwanyị, ebe Metformin na-abanye ike n'ime mmiri ara ma nwee ike imetụta ahụike nke nwa amụrụ ọhụrụ. N'ọnọdụ ndị a, a na-atụ aro ka iji ọgwụ insulin dochie anya ọgwụ ahụ.

A naghị akwado ọgwụ ahụ maka ndị ọrịa meworo agadi nke afọ ha karịrị afọ 60. Na mgbakwunye na nnukwu ibu, Gluconorm nwere ike ibute lactic acidosis na ụdị ndị a.

Ọgwụ chọrọ nlekọta nlezianya site n'aka ndị ọrịa na-arịa:

• adrenal ezughi ezu,
• ahu ọkụ
• ọrịa thyroid.

Maka ọgwụ, a na-enye ọtụtụ ntuziaka pụrụ iche:

• n'oge ọgwụgwọ, ịdị na-enyocha ọ̀tụ̀tụ̀ glucose ọ̀tụ̀tụ̀ ọbara dị mkpa ma afọ na afọ na mgbe i richara nri,
• amachibidoro ị jointụ ọgwụ na mmanya.
• Ọ dị mkpa iji ọgwụ insulin dochie ọgwụ ma ọ bụrụ na onye ọrịa nwere mmerụ ahụ, ọrịa, ahụ ọkụ, ọkụ, arụmọrụ gara aga,
• 2bọchị 2 tupu iwebata ihe na - eme radipaque nke nwere ayodiin n'ime ahụ onye ọrịa, ọ dị mkpa ịkwụsị ị theụ ọgwụ ahụ (mgbe ụbọchị abụọ gasịrị, ịmaliteghachi oriri ahụ),
• nchịkwa nkwonkwo nke Gluconorm na ethanol na-akpalite hypoglycemia, ọ na-adịkwa n’oge a na-ebu ọnụ ma na-a drugsụ ọgwụ mgbochi mkpali nke ụdị steroid,
• ọgwụ a na-emetụta ike onye ọrịa ịnya ụgbọ ala (must ga-ezere iji ụgbọ ala na-eme njem n'oge ị withgwọ ọgwụ).

Echiche onye ọrịa

Nyocha ọtụtụ ndị ọrịa mamịrị gbasara ọgwụ Gluconorm nwere mmetụta dị mma maka ị theụ ọgwụ, agbanyeghị, etinyere nsonaazụ dị iche iche, n'etiti ọgbụgbọ na isi ọwụwa na-ezutekarị, bụ nke a na-ewepụ site na idozi dose.

Ọgwụ dị mma, ọ na-ebelata shuga nke ọma. N'ụzọ dị ịtụnanya, ahụghị m mmetụta ọ bụla na-adịkarị ka ọ na-ede banyere ya. Dị ọnụ ọnụ ọnụahịa. Ana m enye iwu Gluconorm na usoro na - aga n'ihu.

Anọ m na-arịa ụdị ọrịa shuga 2 ruo ọtụtụ afọ. Dọkịta na-aga ahụ nyere ọgwụ Gluconorm. Na mbido, enwere nsonaazụ: mgbe mgbe ọ na-arịa ọrịa, enwere nkụwa. Ma n ’ọdịniihu, anyị dozigharịrị ọnya, ma ihe niile gafere. Ngwá ọrụ dị irè ma ọ bụrụ na ijikọta nri ya na nri.

A na-atụkwasị obi glconorm kpamkpam. N'ọnọdụ nke m, enyere m aka imeziwanye ibu ahụ. Ọgwụ na-ebelata agụụ. N'ime minuses, aga m akọwapụta nsonaazụ ndị ọzọ. E nwere ọtụtụ n’ime ha. N’otu oge, isi m rịawara ọrịa.

Ọ bụghị oge dị anya gara aga, onye ọrịa endocrinologist mere nchọpụta nchọpụta na-adịghị mma - ụdị shuga 2. Edere glucose na-edozi shuga ọbara. N'ozuzu obi ụtọ na ọgwụgwọ. Na nnukwu shuga, ọgwụ nwere ike belata ọkwa ya ruo 6 mmol / L. Enwere mmetụta ụfọdụ dị na ya, mana a na-ewepụ ya. Iri nri.

Ọnụ ego gluconorm na mpaghara dị iche iche nke mba ahụ nwere ọdịiche. Ọnụ ego ná mba ahụ bụ 212 rubles. Ọnụ ego ọgwụ ahụ bụ 130-294 rubles.