Etu esi eji ogwu Gluconorm?

Aha mba ofesi - gluconorm

Ngwakọta na ụdị ntọhapụ

Mbadamba ihe mkpuchi acha ọcha, gburugburu, biconvex. Otu mbadamba 1 nwere glibenclamide 2.5 mg, metformin hydrochloride 400 mg.

Ndị pụrụ iche: microcrystalline cellulose - 100 mg, ọka ọka - 20 mg, colloidal silicon dioxide - 20 mg, gelatin - 10 mg, glycerol - 10 mg, magnesium stearate - 7 mg, talcum ntụ ntụ - 15 mg, croscarmellose sodium - 30 mg, sodium carboxymethyl starch. - 18.3 mg, cellularphate - 2 mg, diethyl phthalate - 0.2 mg.

10 PC. - blisters (1, 2, 3, 4) - ngwugwu nke kaadiboodu.
20 nkp. - blisters (1, 2, 3, 4) - ngwugwu nke kaadiboodu.
30 PC - blisters (1, 2, 3, 4) - ngwugwu nke kaadiboodu.

Linlọ ọgwụ na ọgwụ ọgwụ

Ogwu hypoglycemic ọgwụ.

Ndị na-ere ọgwụ

Ọrịa hypoglycemic maka nchịkwa ọnụ (sulfonylurea nke ọgbọ II + biguanide).

Omume ọgwụ

Gluconorm bụ ngwongwo abụọ nke ọgwụ hypoglycemic nke otu ọgwụ dị iche iche: metformin na glibenclamide.

Metformin bụ nke otu biguanides ma belata ogo nke glucose n'ọbara ọbara site na ịbawanye ụba nke akwara anụ ahụ maka imeju insulin na ịkwalite ume glucose. Na-ebelata nnabata nke carbohydrates na nri diges ma na-egbochi gluconeogenesis na imeju. Ọgwụ ahụ nwekwara mmetụta bara uru na profaịlụ nke ọbara, na-ebelata ogo nke cholesterol dị ala. LDL na triglycerides. Emeghị mmeghachi omume hypoglycemic.

Glibenclamide bụ nke otu usoro nke sulfonylurea nke ọgbọ nke abụọ. Ọ na - eme ka mmiri ọgwụ insulin dị ala site na iwetulata ọnụego glucose nke reat-cell na - eme ka ọ dịkwuo ala, na - emewanyewanye insulin na ya na - ejikọ ya na mkpụrụ ndụ, na - eme ka mwepụta insulin dịkwuo mma, na - eme ka mmetụta nke insulin nwee ike na akwara umeji na - egbochi lipolysis na adipose anụ ahụ. Ọrụ nke abụọ nke insulin insulin.

Pharmacokinetics nke Gluconorm

Mgbe ejiri hazie, nnabata si eriri afọ bụ 48-84%. Oge iru C_max - 1-2 awa V_d - 9-10 lita. Nkwukọrịta na protein protein bụ 95%.

Ọ fọrọ nke nta ka ọ bụrụ metabolized n'ime imeju ya na imepụta metabolites abụọ na-adịghị arụ ọrụ, otu n'ime ya bụ akụrụ ya na nke ọzọ na eriri afọ. Ndi_1/2 - site na 3 ruo 10-16 awa

Mgbe nchịkwa ọnụ gasịrị, ọ na-ewepu site na eriri afọ zuru ezu, 20-30% nke ọgwụ ahụ ka a na-ahụ oria. Ezigbo bioavailability sitere na 50 ruo 60%. Site na ntinye n'otu oge, nnabata nke metformin na-ebelata ma na-egbu oge. A na-ekesa ya ngwa ngwa na anụ ahụ, ihe fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein.

Ọ bụ metadolized ruo obere adịghị ike ma kpụrụ ya akụrụ. Ndi_1/2 odika awa 9-12

Diabetesdị shuga 2 n'ime ndị okenye:

- na enweghi nsogbu nke usoro nri, mmega ahụ na usoro ọgwụgwọ gara aga nwere metformin ma ọ bụ glibenclamide,

- iji dochie ọgwụ gara aga ya na ọgwụ abụọ (metformin na glibenclamide) na ndị ọrịa nwere ọkwa glucose ọbara dị mma ma na-achịkwa nke ọma.

Usoro onunu ogwu na usoro nke Gluconorm

A na-eji ọgwụ eme ọnụ, ya na nri. Ọ bụ dọkịta ga-ekpebi ọ̀tụ̀tụ̀ ọgwụ ahụ n’otu n’otu n’otu n’arụrụ onye ọrịa ọ bụla, dabere n’ogologo glucose ọbara.

Otutu ogwu mbu bu 1 tab. (400 mg / 2.5 mg) / ụbọchị. Kwa izu 1-2 mgbe ịmalite ọgwụgwọ, a na-edozi ọ̀gwụ nke ọgwụ ahụ dabere na ọkwa glucose ọbara. Mgbe ị na-eji metformin na glybeklamide dochie usoro ọgwụgwọ agakọ gara aga, a na-enye mbadamba 1-2. Gluconorm dabere na usoro izizi nke akụkụ ọ bụla.

Oke kachasị kwa ụbọchị bụ mbadamba ise.

Mmetụta akụkụ

Allergic na immunopathological mmeghachi omume: adịkarịghị - urticaria, erythema, itching akpụkpọ, ahụ ọkụ, arthralgia, proteinuria.

Si n'akụkụ nke carbohydrate metabolism: hypoglycemia kwere omume.

Site na sistemụ hemopoietic: ọ na - adịkarịghị - leukopenia, thrombocytopenia, erythrocytopenia, ọ dị ụkọ - agranulocytosis, hemolytic ma ọ bụ megaloblastic anaemia, pancytopenia.

Site n'akụkụ nke usoro ụjọ ahụ: isi ọwụwa, ọgbụgbọ, ike ọgwụgwụ, ike ọgwụgwụ, adịkarịghị - paresis, nsogbu uche.

Mmeghachi omume akpụkpọ anụ: adịkarịghị - photosensitivity.

Site na eriri afọ na akwara: ọ dịkarịghị - ọgbụgbọ, ọgbụgbọ, mgbu afọ, agụụ, agụụ "ụtọ" n'ọnụ, n'ụzọ ụfọdụ - cholestatic jaundice, ụba ọrụ nke enzymes imeju, ịba ọcha n'anya.

Site n'akụkụ nke metabolism: lactic acidosis.

Ndị ọzọ: oke mmeghachi omume nke mmanya na-egbu egbu mgbe mmanya gasịrị, nke e gosipụtara site na nsogbu nke akụkụ ahụ na akụkụ iku ume (disulfiram-like reaction: vomiting, sensation nke okpukpo ọkụ na ihu na elu ahụ, tachycardia, dizziness, isi ọwụwa).

Gluconorm Contraindications

- ụdị shuga 1

- ọrịa na-efe efe, nnukwu ịwa ahụ, mmerụ ahụ, oke ọkụ na ọnọdụ ndị ọzọ chọrọ ọgwụgwọ insulin,

- mamịrị ketoacidosis, ọrịa mamịrị, ụkwara ume ọkụ,

- nnukwu ọnọdụ nke nwere ike ibute mgbanwe n ’ọrụ akụrụ (akpịrị ịkpọ nkụ, ọrịa siri ike, ujo),

- ọrịa ukwu ma ọ bụ nke na-adịghị ala ala nke gụnyere hypoxia anụ ahụ (obi ma ọ bụ akụkụ okuku ume, ndọkata myocardial infarction, ujo),

- iji maka opekata mpe, tupu elekere iri anọ na asatọ tupu ma ọ bụ n'ime elekere 48 ka ị mụchara nyocha redio ma ọ bụ X-ray na ntinye nke ayodiin nwere ihe dị iche,

- na - ekwenye na nri kalori (ihe kariri 1000 kalori kwa ubochi),

- oke nsogbu gbasara akụrụ,

- nhazi nke miconazole,

- egbu egbu egbu, ị alcoholụbiga mmanya ókè

- lactic acidosis (gụnyere akụkọ ihe mere eme),

- oge inye ara,

- Hypersensitivity na metformin, glibenclamide ma ọ bụ ihe ndị ọzọ sitere na sulfonylurea, yana ihe inyeaka.

A naghị atụ aro ka iji ọgwụ ahụ mee ihe na ndị mmadụ karịa afọ 60 bụ ndị na-arụ ọrụ anụ ahụ dị arọ, nke ejikọtara ya na oke ihe ize ndụ nke ịmalite ọrịa lactic acidosis n'ime ha.

Na ịkpachara anya: ọrịa febrile, adrenal insufficiency, hypofunction of the face pituitary, ọrịa thyroid na arụ ọrụ.

Ime na lactation

N’ime ime, eji gluconorm emee ya. Mgbe ị na-eme atụmatụ ịtụrụ ime, yana n’ihe gbasara afọ ime n’oge iji Gluconorm, ọgwụ a ga-akwụsị ịhapụ ị shouldụ ọgwụ insulin.

A na-egbochi afọ ojuju n'ime mmiri ara, ebe metformin na-abanye n'ime mmiri ara. N'okwu a, ị ga-agbanwere ọgwụ insulin ma ọ bụ kwụsị inye ara.

Jiri maka ọrụ imeju na-arụ ọrụ

Contraindicated na imeju ọdịda.

Jiri maka ọrụ ezighi ezi na-arụ ọrụ

A machibidoro iji ya n'ọrụ na nsogbu akụrụ ọria na nnukwu ọnọdụ nke nwere ike ibute mgbanwe ọrụ arụrụala (akpịrị ịkpọ nkụ, ọrịa dị egwu, ujo),

Jiri ndị ọrịa agadi

A naghị atụ aro ka iji ọgwụ ahụ mee ihe na ndị mmadụ karịa afọ 60 bụ ndị na-arụ ọrụ anụ ahụ dị arọ, nke ejikọtara ya na oke ihe ize ndụ nke ịmalite ọrịa lactic acidosis n'ime ha.

Ntụziaka pụrụ iche maka nnabata

Nnukwu ịwa ahụ na mmerụ ahụ, oke ọkụ, ọrịa na-efe efe na ọrịa febrile nwere ike ịchọ ịkwụsị ọgwụ yana ịhọpụta ọgwụ insulin.

Ọ dị mkpa ịdị na-enyocha ọkwa glucose oge niile n'ọbara na afọ efu na mgbe ị risịrị nri.

E kwesịrị ịdọ ndị ọrịa ọdụ gbasara ịba ụba hypoglycemia n'ọnọdụ ethanol, NSAIDs, na agụụ.

Imeghari otu ọ̀ dị mkpa maka ịghara oke nri anụ ahụ na nke mmetụta uche, mgbanwe nri.

N'oge ọgwụgwọ, a naghị atụ aro ị takeụ mmanya.

Oge 48 tupu a waa ya ahụ ma ọ bụ nchịkwa nke ihe na-enwe rediopaque nke nwere ayodiin, ekwesịrị ịkwụsị nchịkwa gluconorm. A na-atụ aro ịmalite ọgwụgwọ glconorm mgbe awa 48 gachara.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

N'oge ọgwụgwọ, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike ịdị ize ndụ chọrọ mmụba nlebara anya na ọsọ nke mmeghachi omume psychomotor.

Dodoụbiga ya ókè

Dodoụbiga ihe ókè ma ọ bụ ọnụnọ nke ihe ndị dị ize ndụ nwere ike ịkpalite mmepe nke lactic acidosis, dị ka Metforminum bụ akụkụ nke nkwadebe. Mgbe ihe mgbaàmà nke lactic acidosis pụtara (vomiting, mgbu nke afọ, adịghị ike n'ozuzu, nkwonkwo akwara), ị ga-akwụsị ị .ụ ọgwụ ahụ. Lactic acidosis bụ ọnọdụ chọrọ nlekọta ahụike mberede, ọgwụgwọ nke lactic acidosis kwesịrị ịrụ n'ụlọ ọgwụ. Ọgwụ kachasị dị irè bụ ịba ọcha n'anya.

Do overụbiga mmanya ókè nwekwara ike ibute mmepe nke hypoglycemia n'ihi ọnụnọ nke glibenclamide na nkwadebe. Mgbaàmà nke hypoglycemia: agụụ, ọsụsọ gabigara ókè, adịghị ike, palpitations, pallor nke anụ ahụ, paresthesia nke onu mucosa, ịma jijiji, nchekasị n'ozuzu oke, isi ọwụwa, iro ụra, ọgba aghara ihi ụra, echiche nke ụjọ, enweghị nhazi nke mmegharị, nsogbu akwara ozi nwa oge. N'iburu n'ọbara nke hypoglycemia, ndị ọrịa nwere ike ịkwụsị njide onwe onye na ọgụgụ isi.

Site na hypoglycemia dị nro ma ọ bụ nke na-adịghị ala ala, a na-ewere ọnụ na edere dextrose (glucose) ma ọ bụ mmiri shuga. N'ọnọdụ oke hypoglycemia (mwepu nke mmụọ), a na-edozi 40% dextrose (glucose) ma ọ bụ glucagon intravenous, v / m, s / c bụ iv. Mgbe ọ nwetasịrị onwe ya, a ga-enyerịrị onye ọrịa ahụ nri nwere carbohydrate iji gbochie ịmaliteghachi hypoglycemia.

Mmekọrịta na ọgwụ ndị ọzọ

Barbiturates, corticosteroids, adrenostimulants (epinephrine, clonidine), ọgwụ antiepileptik (phenytoin), ndị na-egbochi calcium Channel, ndị na-egbochi carbonic anhydrase inhibitors (acetazolamide), thiazide diuretics, chlortalidone, furosemide, diazanazide, triazene diazent , morphine, ritodrine, salbutamol, terbutaline, glucagon, rifampicin, homonụ nke ayodiin nwere mmiri ọgwụ, lithium salts, na oke onunu ogwu - nicotinic acid, chlorpromazine, mgbochi ogwu na nje.

Ndị na - egbochi ACE (captopril, enalapril), ndị na - egbochi histamine H na - akwalite mmetụta hypoglycemic nke ọgwụ₂ndị na-anabata ọgwụ (cimetidine), ndị na-egbochi antifungal (miconazole, fluconazole), NSAIDs (phenylbutazone, azapropazone, oxyphenbutazone), fibrates (clofibrate, bezafibrat), ọgwụ mgbochi ụkwara nta (ethionamide), salicytates, anticoagulant antagon, MAO, sulfonamides na-arụ ọrụ ogologo oge, cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, ihe na-egbochi ihe nzuzo, reserpine, bromocriptine, na-enupụ isi, pyridoxine, ndị ọzọ ọgwụ hypoglycemic (acarbose, biguanides, insulin), allopurinol.

Ọgwụ ure acidifying (ammonium chloride, calcium chloride, ascorbic acid na nnukwu doses) welie mmetụta ahụ site n’ibelata ogo nke dissociation na ịba ụba reabsorption nke glibenclamide.

Ethanol na - eme ka o nwee ohere nke lactic acidosis.

Metformin na-ebelata C_max na T_1/2 furosemide site na 31% na 42.3%, otu isi.

Furosemide na-abawanye C_max metformin site na 22%.

Nifedipine na-abawanye mmịpụta, C_max na-eji nwayọ kpochapu metformin.

Ọgwụ cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren na vancomycin) zoro ezo na tubules na-asọrịta mpi maka sistemụ tubular ma nwee ike ịbawanye C na ọgwụgwọ ogologo oge._max 60% metformin.

Usoro ahịa ọgwụ ahịa

Ogwu gi bu ogwu.

Usoro na ọnọdụ nchekwa

Ekwesịrị ịchekwa ọgwụ a na nkụ, kpuchie ya site na ìhè, site na ụmụaka agaghị enweta okpomọkụ na-agaghị eru ogo 25 Celsius. Ndụ shelf bụ afọ 3.

Ojiji nke Gluconorm nke ọgwụ naanị dị ka dọkịta nyere ya, ntuziaka maka ntụnye!

Weputara udi ya na ihe mebere ya

A na-emepụta ọgwụ ahụ n'ụdị mbadamba. Otu mbadamba 1 nwere 2.5 mg nke glibenclamide na 400 mg nke metformin hydrochloride dị ka ihe ndị na-arụ ọrụ. Ha dị okirikiri. Agba - site na ọcha ruo ihe fọrọ nke nta ka ọ bụrụ ọcha.

A chọrọ gluconorm n'ịgwọ ọrịa shuga.

Omume ọgwụ

Metformin bụ otu ihe ọgwụ akpọrọ biguanides. Ọkwa shuga dị n’ọbara mgbe a decreụrụ ya na-agbada n’ihi eziokwu ahụ nwere ike ịba n’ihu akwara ugboro ugboro n’ihe insulin na-abawanye. Ihe na-eme ka glucose na-arụ ọrụ karịa. Carbohydrates anaghị abanye ngwa ngwa na usoro nri. Formationmalite glucose na umeji na-eji nwayọ nwayọ. Rationta cholesterol n'ime ọbara na-ebelata. Hypoglycemia enweghị ike ịkpata.

Banyere glibenclamide, a chọpụtara na ọ bụ usoro nke sulfonylurea nke ọgbọ nke abụọ. Ọ na - eme ka insulin na - arụ ọrụ ya, na - ahapụ ya, na - agbadata usoro lipolysis na anụ ahụ adipose.

Ọbara shuga dị n'ọbara mgbe ị na-ewere Gluconorm na-agbadata n'ihi eziokwu ahụ na akwara anụ ahụ na-eme ka ọrụ insulin na-abawanye.

Mlọ ọgwụ

Edebere mkpokọta kachasị nke glibenclamide n'ime ọbara 1-2 awa mgbe ị .ụsịrị ọgwụ. 95% jikọtara ya na protein ndi plasma ọbara. Ire ere fọrọ obere ka ọ bụrụ 100% na-aputa n'ime imeju. Nkeji ọkara dịkarịa ala bụ awa 3, ihe kachasị nwere ike iru awa iri na isii.

Metformin dị bio- 50-60% bioa dị. Nkwukọrịta na protein protein plasma dị ntakịrị, enwere ike ịkọwa nkesa anụ ahụ ka ọ bụrụ otu. Ike gwụrụ, ewepu akụrụ ya. Ọkara ọkara bụ awa 9-12.

Edebere mkpokọta kachasị nke glibenclamide n'ime ọbara 1-2 awa mgbe ị .ụsịrị ọgwụ.

Ihe ngbanwe

Agaghị eme ọgwụgwọ na ọgwụ ahụ mgbe onye ọrịa nwere ọnọdụ ndị a:

• hypoglycemia,
• ọrịa metụtara hypoxia anụ ahụ: infarction myocardial, ọrịa obi na-adịghị ala ala na nsogbu iku ume, ujo,
• ọrịa mamịrị ketoacidosis,
• ụdị shuga 1
• lactic acidosis na porphyria,
• oke ọkụ ma ọ bụ usoro nje na-achọ ọgwụgwọ insulin ngwa ngwa,
• mụbaa ihe iji mee ka ihe ndị dị n’ọrụ ahụ sie ike.

Agaghị eme ọgwụgwọ na ọgwụ ahụ mgbe onye ọrịa nwere ikike ịba ụba nke isi ọrụ ọgwụ ahụ.
Agaghị eme ọgwụgwọ na ọgwụ ahụ mgbe onye ọrịa ahụ nwere ọrịa shuga 1.
Agaghị eme ọgwụgwọ na ọgwụ ahụ mgbe onye ọrịa ahụ nwere infarction myocardial.

Na-arịa ọrịa shuga

Tupu ị pụ ọgwụ, onye ọrịa ọ bụla kwesịrị ịmụ ntuziaka ahụ ka ọ ghara imerụ ahụike ha. O kwesịrị ị doctorụ ọgwụ dọkịta ahụ ga-a .ụ. Ọ na-ekpebi oke kachasị dabere na ọkwa ole glucose dị n'ọbara na-edekọ na onye ọrịa n'oge oge akọwapụtara. Ọtụtụ mgbe, a na-echebara nri echiche.

Oke kachasị elu kwa ụbọchị enweghị ike ịkarị karịa mbadamba ise. N'ụzọ bụ isi, ọ bụ mbadamba 1 kwa ụbọchị (400 mg / 2.5 mg). Site na mmalite ọgwụgwọ, izu 1-2 ọ bụla ụzọ ọgwụgwọ nwere ike ịdozi ndozi, ebe dọkịta na-enyocha mgbanwe na ọkwa glucose ọbara. Ọ bụrụ na ọ daa, mgbe ahụ, yabụ, kwesiri ị belata ya.

O kwesịrị ị doctorụ ọgwụ dọkịta ahụ ga-a .ụ.

Ahụhụ Hematopoietic

Dika mmeghachi omume na-adịghị ahụkebe nke sistem hematopoietic, mmepe nke leukopenia, thrombocytopenia na-eme. Obere oge, mbelata nke ọnụ ọgụgụ leukocytes, megaloblastic anaemia na-etolite.

Dika mmeghachi omume na-adịghị ahụkebe site na sistem hematopoietic, mmepe nke leukopenia na-apụta.

Mmetụta ikike ịchịkwa usoro

N'ihi ihe ngosi nke akwara ozi, ọ ka mma ka ịghara ịchịkwa usoro ndị ahụ.

N'ihi ihe ngosi nke akwara ozi, ọ ka mma ka ịghara ịchịkwa usoro ndị ahụ.

Jiri n'oge ime na lactation

Ekwesighi ị medicationụ ọgwụ a n’oge mmegharị ahụ. Ọ bụrụ na ọ nwere mkpa maka ọrịa shuga, ekwesịrị iji ọgwụ insulin mee ya.

A na-achịkọta Metformin n'ime mmiri ara. Nke a pụtara na n'oge ọgwụgwọ, ịkwesịrị ịkwụsị ọgwụgwọ na ọgwụ ma ọ bụ hapụ inye nwa ara ma nyefee nwatakịrị ahụ aka.

Gluconorm overdose

Ọ bụrụ na ọgwụ dọkịta gwara ka ọ dị nke ukwuu gafere ókè, onye ọrịa ahụ nwere ike ị nweta lactacide, ọgwụgwọ nke ekwesịrị iji ya mee ọnọdụ ya na usoro ịba ọcha n'anya. Hypoglycemia nwere ike ime, nke ga - egosipụta onwe ya site na mpụta nke mmetụta agụụ, ịma jijiji, nsogbu ihi ụra nwa oge na nsogbu akwara ozi.

Njirimara nke ogwu

Gluconorm bụ ọgwụ ejikọtara ọnụ nke na-ejikọ ọgwụ dị iche iche na klas dị iche iche dị ka usoro esi arụ ọrụ.

Akụkụ mbụ nke usoro ahụ bụ metformin, onye na-anọchite anya biguanides, nke na-ahụkarị njikwa glycemic site na imeziwanye nguzogide sel n’ime insulin nke ha na ime ka glucose na-eme ihe ike ngwa ngwa. Na mgbakwunye, biguanide na-egbochi ịmịkọrọ carbohydrates ma gbochie imepụta glucose na umeji. Ọ na - eme ka metformin na abụba buru ibu, na --echekwa oke nchịkọta nke cholesterol na triglycerol.

Glibenclamide, ihe nke abụọ na-arụ ọrụ na ndenye ọgwụ, dị ka onye nnọchi anya klas nke abụọ nke sulfonylurea, na-akwalite mmepụta insulin site na enyemaka nke cells-sel nke pancreas na-ahụ maka usoro a. Ọ na - echebe ha pụọ ​​na glucose na - eme ihe ike, na - eme ka mmegide insulin na ogo nke ligament na sel. Insulin etinyere n’onwe ya na-emetụta nnabata nke glucose site na umeji na akwara, ya mere, anaghị akpụbe ngwaahịa ya na akwa abụba. Ihe ahụ na-arụ ọrụ na ngalaba nke abụọ nke mmepụta insulin.

Njirimara nke pharmacokinetics

Mgbe ịbanye n'ime afọ ahụ, glibenclamide na-abanye na 84%. Cmax (elu nke ọkwa ya) o ruru 1-2 awa. Nkesa site na olu (Vd) bu 9-10 lita. Ihe metụtara ahụ na-egbochi protein na-edozi ọbara site na 95%.

A na-agbanwe akụkụ nke imeju na mwepụta nke metabolites abụọ na-anọpụ iche. Otu n’ime ha kpochapu eriri afọ, nke abụọ - akụrụ. Ndụ ọkara nke T1 / 2 dị n'ime awa 3-16.

Mgbe ịbanye n'ime nri diges, a na-etinye metformin na-arụ ọrụ nke ọma, ọ dịghị ihe karịrị 30% nke dose ahụ ka dị na oche. Bi ndu nke biguanide kariri 60%. N'iji nri ndi ozo, nnabata ogwu na-ebelata. A na-ekesa ya ngwa ngwa, anaghị abanye na nkwukọrịta na protein plasma.

Ludị usoro gluconorm na usoro

Gluconorm, foto nke enwere ike ịhụ na nkebi a, na-abanye na netwọkụ ahịa ọgwụ n'ụdị mbadamba okirikiri convex nwere shei ọcha. N'ebe ọkpọkọ ahụ, ndò ọgwụ ahụ nwere isi awọ. N'ime otu mbadamba ihe, e nwere ihe abụọ dị mkpa dị na nha ndị a: metformin - 400 mg, glibenclamide - 2,5 g. Na-agbakwunye usoro ahụ na filler: talc, cellulose, stachi, glycerol, celbilephate, gelatin, stenes magnesium, croscarmellose sodium, sodium carboxymethyl steide, silicodi dioxide diethyl phthalate.

A na-etinye ọgwụ ahụ na pcs iri ma ọ bụ iri abụọ. n’ime mkpụrụ ndụ ndị emere aluminium. Na kaadiboodu ike nwere ike ịbụ site na abụọ ruo anọ. Maka Gluconorm, ọnụahịa ahụ dị oke ala: site na 230 rubles, ha na-ahapụ ọgwụ edenye ọgwụ. Ndụ nchekwa nke mbadamba bụ afọ atọ. Ọgwụ anaghị achọ ọnọdụ pụrụ iche maka nchekwa.

Etu esi eji Gluconorm

Maka Gluconorm, ntuziaka maka iji iwu ka ịdebe mbadamba mbadamba n'ime nri. Dọkịta na-agbakọọ ọgwụ ahụ n'otu n'otu, na-eburu n'uche njirimara nke ọrịa ahụ, ọrịa metụtara, afọ na ọnọdụ nke ndị ọrịa mamịrị, na mmeghachi ahụ nke anụ ahụ na ọgwụ. Dịka iwu, malite na mbadamba 1 / ụbọchị. Mgbe otu izu ma ọ bụ abụọ gasịrị, ịnwere ike ịtụle nsonaazụ ya, yana na arụmọrụ ezughi oke, mezie ụkpụrụ ahụ.

Ọ bụrụ Gluconorm abụghị ọgwụ ịmalite, mgbe ị na-eji dochie usoro ọgwụgwọ gara aga, a na-enye mbadamba 1-2 na-eburu n'uche usoro ọgwụ gara aga. Onu ogugu puru iche nke puru iche n’otu oge n’azu abuo.

Nyere aka ịdoụbiga mmanya ókè

Ọnụnọ nke metformin na usoro na-akpatakarị nsogbu nke eriri afọ, na oge ụfọdụ lactic acidosis. Site na ihe mgbaàmà nke nsogbu (olu mgbu, adịghị ike, mgbu na mpaghara epigastric, ọgbụgbọ), a kwụsịrị ọgwụ ahụ. Site na lactic acidosis, onye ahụ metụtara chọrọ ụlọ ọgwụ ngwa ngwa. Weghachi ya na hemodialysis.

Ọnụnọ nke glibenclamide na usoro adịghị egbochi mmepe hypoglycemia. O kwere omume ịmata ọnọdụ dị ize ndụ site na agụụ na-achịkwaghị achịkwa, mmụba sweating, tachycardia, tremor, anụ ahụ na-acha odo odo, isomnia, paresthesia, dizziness na isi ọwụwa, nchegbu. Site n'ụdị dị nwayọ nke ihu abụọ, ọ bụrụ na onye amaghị ihe ọ bụla amaghị, a na-enye ya glucose ma ọ bụ shuga. N ’ịda mba, glucose, dextrose, glucagon (40% rd) na-agbanye n’ime iv, im ma ọ bụ n’okpuru anụ ahụ. Mgbe onye ọrịa nwetasịrị onwe ya, a na-enye ya nri nwere carbohydrates ngwa ngwa, ebe ọ bụ na nlọghachi na steeti a na-emekarị.

Nsonaazụ Njikọ Ọgwụ

Njikọ ọnụ na ACE inhibitors, NSAIDs, ọgwụ antifungal, fibrates, salicitates, ọgwụ mgbochi ụkwara ume ọkụ, β-adrenergic blockers, guanethidine, MAO inhibitors, sulfonamides, chloramphenicol, tetracycopyridinum, tetracycodiaminophenide, tetrazinolin tigram, nke tetrazinoin, tetrazinoin, tetrazinoin, tetrazinoum, tetrazinoum, tetrazinoum, tetrazino-tigram, nje-ịgba ọgwụ, tetrazinopyrinum, tetrazinoin, tetrazinoin, tetrazinoin, tetrazinoin, tetrazinoin. .

A na - ebelata ọrụ hypoglycemic nke Gluconorm site na adrenostimulant barbiturates, corticosteroids, ọgwụ mgbochi, diuretics (ọgwụ thiazide), furosemide, chlortalidone, triamteren, morphine, ritodrin, glucagon, homonụ thyroid (nke oestra, iodine, wdg).

Ọgwụ urine acid na-eme ka ihe dị n’ọrụ dị ka ihe na-eme ka ịdị mma dị n’ihu site n’ibelata mgbasa na ịkwalite resorption gluconorm. Ethanol na - eme ka o nwee ohere nke lactic acidosis. Metformin na-emetụta ọgwụ nke ọgwụ furosemide n'ụzọ dị egwu.

Nsonaazụ achọghị

Metformin bụ otu n'ime ọgwụ hypoglycemic kachasị dị nchebe, mana, dịka ọgwụ ọ bụla na-emepụta sịntetị, ọ nwere nsonaazụ ya. Otu n'ime nsogbu ndị a na-ahụkarị bụ ọrịa dyspeptik, nke na-apụ n'anya n'ọtụtụ ndị ọrịa mamịrị mgbe oge ngwụsị oge gachara. Glibenclamide bụkwa ihe eji anwale oge oge ya nwere nnukwu ihe akaebe nke ịdịmma yana nchekwa. Ọnọdụ edepụtara na tebụl ahụ adịkarịghị, mana a ga-atụle ntuziaka tupu ịmalite ọgwụgwọ.

Onye gosipụtara na contraindicated Gluconorm

Edere mbadamba maka ndị ọrịa mamịrị na-arịa ụdị ọrịa nke abụọ, ọ bụrụ na mgbanwe usoro obibi ndụ na ọgwụgwọ mbụ enyeghị 100% nchịkwa glycemic. Ọ bụrụ na iji ọgwụ abụọ dị iche (Metformin na Glibenclamide) na-enye ohere maka nkwụghachi shuga na-adigide, ọ dịkwa mma iji otu ọgwụ dochie ụlọ ọgwụ ahụ - Glucanorm.

Ejila Gluconorm na:

• Ọrịa shuga 1dị 1
• Hypoglycemia,
• Ọrịa mamịrị ketoacidosis, coma na precoma,
• Ọnọdụ ntaramahụhụ na ọnọdụ ndị na-akpata ha,
• Imeju imeju,
• Ọnọdụ oxygen (nke na-akpata nkụchi obi, ọrịa obi, ujo, iku ume), na-akpata ọnọdụ.
• Ọrịa ọgbụgba
• Iji miconazole mee ihe ugbu a,
• Ọnọdụ na-egosi ntụgharị oge ụfọdụ na insulin (n'oge arụmọrụ, mmerụ ahụ, ọrịa, ụfọdụ nyocha iji akara ndị dabere na ayodiin),
• Mmanya na-aba n'anya,
• Lactic acidosis, tinyere akụkọ banyere ahụ ike,
• Ime na lactation
• Hypocaloric (ihe ruru 1000 kcal) nri,
• Hypersensitivity na akụkụ nke usoro.

Ojiji nke Gluconorm site na Ndi dị ime na ndị nọọsụ

Ọbụna n'oge usoro nwatakịrị ahụ na-eme atụmatụ, a ga-eji insulin dochie Gluconorm, ebe ọ bụ na ọgwụ a na-egbochi contraindicated na ọnọdụ a. Mgbe a na-enye nwa ara ara, ihe mgbochi ga-ezu ezu, ebe ọgwụ a na-abanye ọ bụghị naanị site na nwa nwa ebu n’afọ, kamakwa n’ime mmiri ara. Nhọrọ dị n'etiti insulin na inyefe nwatakịrị na nri anụ mere ga-eburu n'uche ihe egwu dịịrị nne ya na ihe nwere ike ibute nwata ahụ.

Ntụziaka pụrụ iche

Nnukwu mmerụ ahụ na arụmọrụ siri ike, ọrịa na-efe efe na ọnya na-ekwu na inyefe onye ọrịa ọgwụ ruo oge ụfọdụ.

E kwesịrị ịdọ ndị na-arịa ọrịa shuga aka ná ntị banyere ihe ize ndụ nke ịmalite hypoglycemia site na iji NSAIDs, mmanya, ethanol, na nsogbu na-adịghị mma.

N'ịgbanwe ụdị ndụ, nri, mmetụta uche na oke ahụ, mgbanwe nke oke ị theụ ọgwụ dị mkpa.

Ọ bụrụ na a ga-enyocha onye ọrịa site na iji akara ayodiin, a na-akagbu gluconorm n'ime ụbọchị abụọ, jiri insulin dochie ya. Can nwere ike ịlaghachi na usoro ọgwụgwọ gara aga tupu oge awa iri anọ na asatọ gachaa ọmụmụ a.

A ga-ebelata ịdị irè nke Gluconorm ma ọ bụrụ na onye ọrịa anaghị esoro nri obere carb, na-eduzi ndụ ibi ndụ, anaghị achịkwa shuga ya kwa ụbọchị.

Gluconorm - analogues

Dabere na koodu ATX nke ọkwa nke anọ, ha jikọrọ Gluconorm:

Nhọrọ na nnọchi nke ọgwụ ahụ bụ naanị na ikike nke ọkachamara. Nyochaa onwe ya na ịgwọ onwe ya na-ebughi n'uche ihe niile dị na akụkụ ahụ nwere ike bụrụ nsonaazụ dị mwute.

Nyocha banyere ọrịa mamịrị

Banyere Gluconorm Ọrịa mamịrị na-arụ ụka. Fọdụ na-arụ ụka na ọgwụ ahụ anaghị enyere aka, enwere ọtụtụ ihe ịtụnanya n'akụkụ, gụnyere ịba ụba. Ndị ọzọ na-ekwu na isi ihe isi ike n’imeso ọgwụ ahụ bụ n ’ịhọrọ usoro a ga-esi mee ya, ma mesịa, shuga ahụ laghachiri na nkịtị. Banyere ahịhịa herbal "Altai 11 Gluconorm with blueberries" na - atụle nyocha: na - enyere aka n'ịhụ ọhụụ, na - eme ka ọdịmma dị mma.

Gluconorm bụ ọgwụ dị mfe iji yana nyocha pụtara na usoro ọgwụgwọ ụlọ ọgwụ dị mkpa. Ejirila Biguanides na ọgwụ sulfanilurea maka ịgwọ ụdị ọrịa shuga 2 ruo ihe karịrị ọkara otu narị, ụdị ọgwụ ọhụrụ a na-aghọrọ ọgwụ mgbochi agbabeghị ikike ha.

Mmekọrịta na ọgwụ ndị ọzọ

A akwadoghị maka iji otu oge eji ọgwụ fenfluramine, cyclophosphamide, ACE inhibitors, ọgwụ antifungal, ka ha na-eme ka mmetụta nke ọgwụ ahụ dịkwuo elu.

Thiazide diuretics nwere iodine thyroid homonụ nwere ike ịkụda ọrụ ya.

Akwadoro ka ijiri were mee ihe na fenfluramine.

Nyocha gluconorm

Ma ndi dibia na ndi oria anwurula nke ogwu ahu ha na ha gha ezi nyocha.

D.E. Tikhonov, GP, Ryazan: “Ọgwụ a na-egosi nsonaazụ ndị magburu onwe ya n'ọgwụgwọ ụdị shuga 2. Ahụ́ na-eru ndị ọrịa ala. ”

O.D. Ivanova, ọkà mmụta ọgwụ endocrinologist, Moscow: “Ana m ewere ọgwụ dị ka ihe kachasị mma maka ịgwọ ọrịa shuga 2, n'ihi na ọ na-enyere aka ngwa ngwa ma na-eme ihe anaghị akpalite ọdịdị nke mmeghachi omume ọjọọ. M ga-ahọpụta ya ọtụtụ mgbe. ”

Ọrịa shuga ludị 1 na 2

Alina, 29, Bryansk: “A ghaara m ọgwụgwọ maka ọrịa siri ike dịka ọrịa shuga. Usoro ọgwụgwọ ahụ dị ogologo, mana ọnọdụ ahụ gbagoro nke ọma. Ya mere, enwere m ike ịkwado ọgwụ a. ”

Ivan, onye gbara afọ 49, Ufa: “Ejiri m ọgwụ ọjọọ n'ụlọ ọgwụ. Enwere m afọ ojuju n'ihe niile, gụnyere nlekọta ndị dọkịta na ọrụ ha. Ha nyochara m na, dabere na nsonaazụ ndị a, depụtara usoro ị doụ ọgwụ. Apụrụ m ịkpọ ọgwụ a ka ọ dị mma ma gwa ya ndị ọrịa niile nwere ọrịa shuga. ”