Ọgwụ Lozap Plus

Aha mba ofesi - Lozap gbakwunyere

Ngwakọta na ụdị ntọhapụ

Mbadamba ihe mkpuchi edo edo na-acha odo odo, oblong, na nkewa ahịrị na ọkara n'akụkụ abụọ. Na Taabụ 1 nwere: losartan potassium - 50 mg, hydrochlorothiazide - 12.5 mg.

Ndị pụrụ iche: mannitol - 89 mg, microcrystalline cellulose - 210 mg, croscarmellose sodium - 18 mg, povidone - 7 mg, magnesium stearate - 8 mg, hypromellose 2910/5 - 6.5 mg, macrogol 6000 - 0.8 mg, talcum ntụ ntụ - 1.9 mg, simethicone emulsion - 0.3 mg, dye Opaspray odo M-1-22801 - 0,5 mg (mmiri asacha ọcha, titanium dioxide, ethanol denatured (mmanya BP: ethanol 99% na methanol 1%)), hypromellose, ntutu Quinolin Yellow (E104), ntutu Pounceau 4R (E124).

Mwepụta weputara: 10 PC. - blisters (1, 3 ma ọ bụ 9 PC.) ma ọ bụ pcs 14. - blisters (2) - ngwugwu nke kaadiboodu.

Linlọ ọgwụ na ọgwụ ọgwụ

Ndị na-ere ọgwụ

Nlekọta ihe ngba maka ihe na-egbu egbu (angiotensin II receptor blocker + diuretic)

Omume ọgwụ

Ọgwụ antihypertensive. Doto angiotensin II nnabata antagonist (subtype AT 1). Ọ naghị egbochi kininase nke abụọ, enzyme nke na-egbochi ntụgharị nke angiotensin I na angiotensin II. Na-ebelata OPSS, ịta ọbara nke adrenaline na aldosterone, ọbara mgbali, nrụgide na mgbasa nke akwara, na-ebelata ibu ọrụ, nwere mmetụta diuretic. Ọ na-egbochi mmepe nke hypertrophy myocardial, na-eme ka nnabata mmega ahụ nwee ndị ọrịa nwere nkụda mmụọ obi na-adịghị ala ala. Losartan anaghị egbochi ACE kininase II na, n'ihi ya, anaghị egbochi mbibi bradykinin, ya mere, mmetụta ndị ọzọ na-emetụtaghị bradykinin (dịka ọmụmaatụ, angioedema) dị ụkọ.

N'ime ndị ọrịa nwere ọbara mgbali elu na - enweghị conellitus diabetes mellitus nwere proteinuria (karịa 2 g / ụbọchị), iji ọgwụ ahụ belata proteinuria, oke nke albumin na immunoglobulins G.

Na-eme ka ọkwa urea dị na plasma ọbara. Ọ naghị emetụta ya site na mgbanwe nke ahịhịa na - enweghị mmetụta ogologo oge na mkpokọ nke norepinephrine na plasma ọbara. Losartan na dose nke ruru 150 mg / ụbọchị anaghị emetụta ọkwa nke triglycerides, cholesterol na HDL kọlesterol n'ọbara ọbara na ndị ọrịa nwere ọbara mgbali elu. N'otu usoro, losartan anaghị emetụta glucose ọbara na-ebu ọnụ.

Mgbe otu mkpụrụedemede ọnụ gasịrị, mmetụta hypotensive (systolic na diastolic ọbara na-ebelata) ruru oke mgbe awa 6 gachara, jiri nwayọ belata n'ime awa 24.

Mmetụta hypotensive kachasị na-etolite izu 3-6 mgbe mmalite ọgwụ.

Mlọ ọgwụ

Mgbe etinyere ya, losartan na-anabata nke ọma, ọ na-enwetakwa metabolism n'oge "ụzọ mbụ" site na imeju site na carbonxy na ntinye nke cytochrome CYP2C9 isoenzyme na ịmalite nke metabolite na-arụ ọrụ. Adị bioav adị nke losartan dị ihe dịka 33%. A na-enweta mkpokọta kachasị nke losartan na metabolite na-arụ ọrụ na ọbara ọbara mgbe ọ dị ihe dị ka elekere 1 na awa 3-4 mgbe ịbanyesịrị, n'otu n'otu. Iri nri anaghị emetụta ndu okike nke losartan.

Ihe karịrị 99% nke losartan na metabolite na-arụ ọrụ ya na-egbochi protein protein, tumadi na albumin. V d losartan - 34 l. Losartan adịghị abanye na BBB.

Odika 14% nke losartan nke a na-enye ma ọ bụ n’onu ka a gbanwere n’ime metabolite na-arụ ọrụ.

Mkpochapụ plasma nke losartan bụ 600 ml / min, na metabolite na-arụ ọrụ bụ 50 ml / min. Nwepu nke losartan na metabolite ya na-arụ ọrụ bụ 74 ml / min yana 26 ml / min, n'otu n'otu. Mgbe ingesred, ihe dị ka 4% nke ọgwụ a na-ewepụ ya bụ akụrụ na-agbanweghi agbanwe ihe dịka 6% na-apụkwa na akụrụ n'ụdị metabolite na-arụ ọrụ. A na-eji Losartan na metabolite na-arụ ọrụ ya na ọgwụ ọgwụ linear mgbe a na-eji ọnụ nye ya ihe ruru 200 mg.

Mgbe nchịkwa ọnụ gasịrị, plasma ahụ nke losartan na metabolite na-arụ ọrụ ya na-agbada nke ukwuu na ọkara ndụ ikpeazụ nke losartan nke ihe dị ka awa 2, na nke metabolites na-arụ ọrụ nke ihe dị ka awa 6-9. Mgbe ị na-a theụ ọgwụ ahụ na ọgwụ nke 100 mg / ụbọchị, ma losartan ma ọ bụ metabolite na-arụsi ọrụ ike na-agbakọta nke ukwuu na ọbara plasma. A na-ahụ Losartan na metabolites ya na eriri afọ na akụrụ. N'ime ndị ọrụ afọ ofufo nwere ahụike, mgbe ịbatara losartan akara na 14 C-isotope, ihe dị ka 35% nke akara redioaktivu na-ahụ na mmamịrị na 58% na feces.

Pharmacokinetics n'ihe gbasara ọrịa

N'ime ndị ọrịa nwere nsogbu ịrụ mmanya na-egbu egbu ruo obere ruo n'ọtụtụ, losartan bụ oge 5, metabolite na-arụ ọrụ ji okpukpu 1.7 karịa nke ndị ọrụ afọ ofufo nwere ahụ ike.

Site na CC> 10 ml / min, itinye uche nke losartan na plasma ọbara adịghị iche na nke ahụ na-arụ ọrụ na-arụ ọrụ na nkịtị. N'ime ndị ọrịa chọrọ ọgwụgwọ maka ịba ọcha n'anya, AUC dị ihe dị ka ugboro abụọ karịa nke ndị ọrịa nwere ọrụ mkpo nkịtị.

Abughi losartan ma ọ bụ metabolite na-arụ ọrụ na-ewepụ site na ahụ site na hemodialysis.

Ọkpụkpọ nke losartan na metabolites na-arụ ọrụ na plasma ọbara n'ime ụmụ nwoke meworo agadi na-arịa ọbara mgbali elu adịghị iche na ụkpụrụ nke paramita ndị a na ụmụ okorobịa na-arịa ọbara mgbali elu.

Mkpoko plasma nke losartan n'ime ụmụ nwanyị nwere ọbara mgbali elu okpukpu abụọ dị elu karịa ụkpụrụ kwekọrọ na ụmụ nwoke nwere ọbara mgbali elu. Ntinye uche nke metabolite na-arụ ọrụ n’ime ụmụ nwoke na ụmụ nwanyị adịghị iche. Ọdịiche ụlọ ọrụ ọgwụ a abụghị ihe dị mkpa banyere ọgwụ.

• ọbara mgbali (akwara ịgwọ ọrịa maka ndị ọrịa ọ dị mma ọgwụgwọ a).
• belata ohere ibute ọrịa obi na onwu na ndị ọrịa nwere ọbara mgbali elu na mgbali ventricular.

Ihe ngbanwe

• hypokalemia na-egbochi ọgwụgwọ ma ọ bụ hypercalcemia,
• nnukwu ọrịa imeju,
• igbochi oria nke biliary tract,
• hyponatremia refractory,
• hyperuricemia na / ma ọ bụ gout,
• oke arụmọrụ gbasara akụrụngwa (CC ≤ 30 ml / min),
• ngbaka
• tụụrụ ime
• oge inye ara,
• afọ ruo afọ 18 (arụpụtaghị na ịdị adị na nchekwa),
• hypersensitivity na akụkụ nke ọgwụ ma ọ bụ ọgwụ ndị ọzọ sitere na sulfonylamide.

Na ịkpachara anya ka enyere ndị ọrịa nwere obere akwara akwara akwara ma ọ bụ stenosis nke otu akwara akwara, ọnọdụ hypovolemic (gụnyere afọ ọsịsa, ọgbụgbọ), hyponatremia (ohere dị ukwuu na-arịa hypotension na ndị ọrịa na obere nri nnu ma ọ bụ nnu), hypochloremic alkalosis, hypomagnesemia, ọrịa anụ ahụ (gụnyere SLE), ndị ọrịa nwere ọrụ imeju na-arịa ya ma ọ bụ nwee ọrịa imeju na-aga n'ihu, ọrịa shuga mellitus, ụkwara ume ọkụ (gụnyere akụkọ ihe mere eme), onye na-arịa ọrịa allergist dị arọ. cal akụkọ ihe mere eme, n'out oge na NSAIDs, gụnyere Ndị na-egbochi COX-2, yana ndị nnọchi anya agbụrụ Negroid.

Usoro usoro onunu ogwu na usoro nke ngwa Lozapa Plus

A na -e oara ọgwụ ahụ ọnụ, n'agbanyeghị nri.

Na ọbara mgbali ike mbụ a na-ahụ maka ya na mmezi ya bụ 1 mbadamba / ụbọchị. Ọ bụrụ na mgbe ị na-eji ọgwụ ahụ na ọgwụ a, ọ gaghị ekwe omume ịnweta nchịkwa ọbara zuru oke, enwere ike ịbawanye dose nke ọgwụ Lozap Plus na mbadamba abụọ. 1 oge / ụbọchị

Ogo kachasị nari bụ mbadamba abụọ. 1 oge / ụbọchị Na mkpokọta, enwere mmetụta hypotensive kacha mma n'ime izu 3 mgbe mmalite ọgwụgwọ.

Enweghị mkpa maka nhọpụta mbụ maka mbụ ndị ọrịa agadi.

Na iji belata ihe ize ndụ nke ịmalite ọrịa obi na onwu na ndị ọrịa nwere ọbara mgbali elu na mgbali ventricular hypertrophy. Ejiri losartan (Lozap) na ọkwa mbido 50 mg / ụbọchị. Ndị ọrịa na-emezughị ihe mgbaru ọsọ ọbara mgbali elu mgbe ị na-eji losartan na ọgwụ nke 50 mg / ụbọchị chọrọ ọgwụgwọ na ngwakọta nke losartan na hydrochlorothiazide na obere ọgwụ (12.5 mg), nke enyere ọkwa Lozap Plus ọgwụ. Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye dose nke Lozap Plus na mbadamba abụọ. (100 mg nke losartan na 25 mg nke hydrochlorothiazide) 1 oge / ụbọchị.

Mmetụta akụkụ Lozapa Plus

A na-ekesa mmeghachi omume ọjọọ dịka oge nke mmepe dị ka ndị a: ugboro ugboro (≥ 1/10), ugboro ugboro (≥ 1/100 na

Kedu ihe kpatara eji eme nnyocha EMIS na infertility?

Galvanized pleurisy nke ọrịa ngụgụ na ọgwụgwọ - gụọ ozi niile gbasara ọrịa kansa na weebụsaịtị nke European Clinic.

Mwepụta wepụtara ya na ihe mejupụtara

Lozap Plus dị n'ụdị mbadamba ndị nwere ihe nkiri: oblong, nwere ihe egwu n'akụkụ abụọ, edo edo edo (pcs 10. Na blisters, na ngwungwu kaadiboodu nke 1, 3 ma ọ bụ 9 blisters, pcs 14. Na blisters, na kaadiboodu. ngwugwu nke 2 blisters).

Nchikota kwa otu mbadamba 1:

• bekee na-arụ ọrụ: hydrochlorothiazide - 12.5 mg, losartan potassium - 50 mg,
• ihe inyeaka: microcrystalline cellulose, povidone, mannitol, magnesium stearate, ssumum croscarmellose,
• mkpuchi ihe nkiri: macrogol 6000, simethicone emulsion, crimson dai Ponso 4R, hypromellose 2910/5, talc, titanium dioxide, quinoline odo odo.

Mlọ ọgwụ

Lozap gbakwunyere bụ ọgwụ ngwakọta nke nwere mmetụta hypotensive. Losartan bụ ihe nnabata angiotensin II, hydrochlorothiazide bụ thiazide diuretic.

Akụkụ ọgwụ ndị dị n'ọrụ nke ọgwụ ahụ na-egosipụta mmetụta synergistic, na-ebelata ọbara mgbali elu yana oke karịa karịa n'otu n'otu.

Losartan na-agbadata OPSS (ngụkọta akwara vaskụla), na-ebelata mkpụkọ nke aldosterone na adrenaline n'ime ọbara, na-ebelata nrụgide na mgbasa akwara, na-emepụta mmetụta diuretic ma na-ebelata ibu. N'ime ndị ọrịa nwere ọrịa obi na-adịghị ala ala, losartan na-abawanye iguzogide mmega ahụ, na-egbochi nhụsianya nke akwara obi.

Hydrochlorothiazide na-eme ka mmịpụta phosphates mmịpụta, bicarbonate na potassium ion belata mmeghachi nke sodium ion. A na-enweta mmụba ọbara site na ịgbanwe ọrụ nke mgbidi vaskụla, belata olu nke na-ekesa ọbara, na-eme ka mmetụta ahụ gwụwanye ike na ganglia ma belata mmetụta nke vasoconstrictor bekee.

Mmetụta antihypertensive nke Lozap gbakwunyere awa 24. Illsnweta ọgwụ anaghị enwe mmetụta dị ukwuu n ’obi obi. Ọgwụ a na-ebelata ọbara ọgbụgba na ma ụmụ nwoke ma ụmụ nwanyị, ndị okenye na ndị okenye, ndị ọrịa Negroid na agbụrụ ndị ọzọ, yana ogo ogo ọbara ọgbụgba.

Mlọ ọgwụ

Losartan na-enweta ngwa ngwa site na nri diges. Ya bioavailability bụ ihe dị ka 33% n'ihi nsonaazụ nke mbụ site na imeju. Metabolism na-eme site na carboxylation, nke na-ebute nguzobe metabolite na - arụ ọrụ - carboxylic acid. Losartan 99% na-ejikọ protein protein. Ntinye uche ya kachasị na plasma erutela mgbe elekere 1 gachara, ma tinye uche nke metabolite nọ n'ọrụ ka awa 3-4 gachara. Iri nri anaghị emetụta oke mkpokọta plasma nke losartan. Olu nke nkesa bụ lita 34. Losartan fọrọ nke nta ka ọ ghara ịbanye n'ime mgbochi ụbụrụ. Ndụ ọkara nke losartan bụ awa 1.5-2, carbonxylic acid bụ awa 3-4. Ihe dị ka 35% nke ọgwụ a isụbara dị na mmamịrị na ihe dịka 60% na feces.

Ntinye mmiri hydrochlorothiazide dịkwa ngwa ngwa, imeju na-emepụtaghị ya. Hydrochlorothiazide adịghị agafe ihe mgbochi ụbụrụ ọbara ma ọ bụ mmiri ara na-ezobe ya, kama ọ na-abanye n'ihe mgbochi placental. Iwepu ọkara ndụ bụ 5.8-14.8 awa. Ihe dị ka 61% nke hydrochlorothiazide bụ akụrụ na-agbanweghi agbanwe.

Usoro ọgwụ Lozap gbakwunyere na ndị agadi agadi adịghị iche na nke ndị ọrịa na-eto eto.

Site na imeju nke imeju na-egbu egbu ma ọ bụ na-adịghị ala ala, akụrụngwa nke plasama nke losartan na metabolite na-arụ ọrụ bụ oge 5 na 1.7 karịa, n'otu n'otu, karịa ndị ọrụ afọ ofufo ahụ siri ike. Usoro ọgwụgwọ adịghị irè.

Ihe ngbanwe

• nnukwu ọrịa imeju,
• oke arụmọrụ akụrụngwa (arụkwaghịm nke na-erughi 30 ml / min),
• cholestatic ọrịa
• mkpali na-egbochi ọrịa nke biliary tract,
• enweghi mmamiri na eriri afo (anuria),
• hypercalcemia ma ọ bụ hypokalemia (na-eguzogide ọgwụgwọ),
• gout na / ma ọ bụ ọrịa hyperuricemia,
• hyponatremia refractory,
• ime na lactation,
• ụmụaka na ndị na-eto eto nọ n’agbata afọ 18,
• ngalaba na aliskiren na ndị ọrịa nwere akụrụ akwara (mwepụ nke okike erughi 60 ml / min) na ọrịa shuga,
• hypersensitivity na isi ma ọ bụ inyeaka ọgwụ.

Ikwu (Lozap gbakwunyere na-eji ịkpachara anya):

• hypovolemia (gụnyere vomiting ma ọ bụ afọ ọsịsa),
• hypoomagnesemia, hyponatremia, hypochloremic alkalosis, hypokalemia,
• hyperkalemia
• akwara obi
• obi ike ọgwụgwụ,
• obi nkoropụ, tinyere nnukwu akwara oke,
• nkụda obi na ihe egwu na-egbu ndụ,
• mitral ma ọ bụ aortic stenosis,
• ike obara nke obara,
• ọrụ imeju na-arụ ọrụ,
• ọrịa imeju na-aga n'ihu,
• nnụnụ n'otu (n'ihe gbasara otu akụrụ) resal artery stenosis,
• Ọnọdụ mgbe akụrụ ntụgharị,
• ụkwara ume ọkụ (gụnyere akụkọ ihe mere eme),
• ihe jikọrọ anụ ahụ
• hyperaldosteronism,
• akụkọ banyere ụbụrụ Quincke,
• Ibu akụkọ banyere adịghị nfe,
• ọrịa ụbụrụ,
• nnukwu ọgụ nke akụkụ mmechi glaucoma na myopia,
• n'otu oge iji ọgwụ mgbochi na-abụghị steroidal,
• sitere na agbụrụ Negroid,
• ịka nká karịa afọ 75.

Lozap gbakwunyere, ntuziaka maka ojiji (usoro na usoro onunu ogwu)

A na-eji ọnụ ede okwu Lozap tinyere mbadamba, n'agbanyeghị nri.

N'ime ndị ọrịa nwere ọbara mgbali elu, a na-edenye ọgwụ ahụ na mbido na mmezi nke mbadamba 1 kwa ụbọchị. Ọ bụrụ n indicated usoro egosipụtara ezubeghị iji belata obara mgbali zuru oke, ọ ga - ekwe omume ịbawanye ọgwụ a rue mbadamba abụọ otu ugboro n’ụbọchị.

Oke kachasị kwa ụbọchị nke ọgwụ ahụ bụ mbadamba nkume abụọ, a na-enwetakwa mmetụta kachasị hypotensive n'ime izu atọ mgbe mmalite ọgwụgwọ.

Maka ndị ọrịa agadi, a na-enye Lozap gbakwunyere na usoro izizi nke mbụ.

Iji belata ihe egwu na ọrịa obi na onwu, ọgwụ izizi losartan bụ 50 mg otu ugboro n'ụbọchị (1 mbadamba Lozap). Ọ bụrụ na ọgwụgwọ anaghị arụ ọrụ, ọ dị mkpa ịhọrọ ọgwụgwọ site na ijikọta losartan na obere hydrochlorothiazide (1 mbadamba ọgwụ Lozap + 1 mbadamba ọgwụ Lozap na ọgwụ kwa ụbọchị). N'ọdịnihu, ọ ga - ekwe omume ịbawanye ọgwụ a na mbadamba abụọ abụọ nke ọgwụ Lozap gbakwunyere otu ugboro n'ụbọchị.

Nsonaazụ

Nsonaazụ nke ọgwụ n'ihi nchikota nke losartan + hydrochlorothiazide:

• umeji na ọnya biliary: adịkarịghị - ịba ọcha n'anya,
• sisitemu obi: onaghi agha ugboro - mmetụta orthostatic (dose dependant),
• ụjọ usoro: adịkarịghị - anya ntughari, ugboro ugboro amaghi - imebi echiche ụtọ,
• anụ ahụ na akpụkpọ anụ subcutaneous: ugboro ugboro amaghị - systemic lupus erythematosus (ụdị akpụkpọ),
• ihe omumu na ihe omumu: ihe kariri - ubara oru nke enzymes imeju, hyperkalemia.

Nsonaazụ nke ọgwụ Lozap gbakwunyere, n'ihi ọdịnaya nke losartan na ihe mejupụtara ya:

• eriri afọ, akwara na ọnya biliary: oge ​​- ọgbụgbọ, ọnyụnyụ ọnya na -akpata, afọ na-agafe agafe, ọnụnọ ewepụghị, ugboro ugboro - akpọnwụ akpịrị, ọgbụgbọ, eze mgbu, gastritis, afọ ntachi, flatulence, ugboro-amaghị - ọrụ imeju na-arụ ọrụ,
• sisitemu akwara: ike oge - orthostatic hypotension, angina pectoris, myocardial infarction, arrhythmias, mbelata ọbara mgbali, mgbu na sternum, vasculitis, ngọngọ mgbochi nke II, isi ọria, palpitations,
• sistem lymphatic na ọbara: ugboro ugboro - mbufụt n’ahụ ma ọ bụ akpụkpọ ahụ, anaemia, erythrocytosis, ọrịa Shenlein-Genoch, ugboro ole amaghi - thrombocytopenia,
• sistem akụkụ iku ume: ọtụtụ mgbe - mkpọchi imi, ụkwara, sinusitis, oke akụkụ nke akụkụ iku ume, na - adịkarịghị - laryngitis, bronchitis, rhinitis, pharyngitis, dyspnea, nosebleeds,
• sistemu ụjọ na psyche: oge ​​ụfọdụ - nkụda mmụọ, nsogbu ehighị ụra, isi ọwụwa, ugboro ugboro - nchekasị, nsogbu ịrahụ ụra, mgbakasị ahụ, nchekasị, nrọ ndị pụrụ iche, ụjọ ịma jijiji, nkụja, ịda mba, iro ụra, nche anwụ, isi ọwụwa, ụbụrụ nchekasị, akwara ozi, ịda mba,
• akwara anụ ahụ: ugboro ugboro - conjunctivitis, ọhụhụ ọhụhụ, gbupụrụ anya visual, anya na-enwu n'anya, na-akụ ntị, vertigo,
• usoro akwara: mgbe mgbe - ihe mgbu n’ụkwụ na azụ, sciatica, olu mgbu, adịghị ala ala - mgbu n’ọkpụkpụ na akwara, ogbu na nkwonkwo, ike ọgwụgwụ, akụkụ ahụ, nkwonkwo, fibromyalgia, isi ike nke nkwonkwo, a na-amata ugboro ugboro - myoglobinuria na ọdịda akwara,
• Usoro urinary: ọtụtụ mgbe - ọdịda akụrụ, ọrụ akwara nwere nsogbu, ugboro ugboro - urinary tract na-efe efe, ugboro ugboro urination, ihe juru ebe nile n'abali n'abalị.
• usoro omumu: na - enweghi nsogbu - akwara ivu, mbelata nke libido,
• akpukpo aru na okpukpo okpukpo: okpukpu ugboro - dermatitis, erythema, photosensitivity, fri akpụkpọ, ntutu isi, akpukpo aru, hyperemia, itching skin, sweating,
• sistemu na - aghaghi agha: na adighi ike - Quincke edema, anafilactic,
• metabolism na oriri na-edozi: ugboro ugboro - gout, anorexia,
• ọmụmụ ụlọ nyocha na akụrụngwa: oge ​​- ntakịrị mbelata hemoglobin na hematocrit, hyperkalemia, na - adịghị obere - ntakịrị mmụba na plainma creatinine na urea, ọ dịkarịghị - mmụba na bilirubin na ọrụ enzyme imeju, a maghị ugboro ole - mbelata nke sodium ndọpụ,
• mmeghachi omume ndị ọzọ: mgbe mgbe - ike ọgwụgwụ, mgbu obi, asthenia, ugboro ugboro - ahụ ọkụ, ọzịza na ihu, oge amabeghị - adịghị ike, ihe mgbaàmà nke oria-dị ka ọrịa.

Nsonaazụ nke ọgwụ Lozap gbakwunyere, n'ihi ọdịnaya nke hydrochlorothiazide na ihe mejupụtara ya:

• eriri afọ, akwara na ọnya biliary: ugboro ugboro - ọgbụgbọ, cramps, vomiting, gastritis, pancreatitis, mbufụt nke gland ọnya, afọ ntachi ma ọ bụ afọ ọsịsa, cholecystitis, cholestatic jaundice,
• sisitemu obi: ugboro ugboro - vasculitis (akpụkpọ ma ọ bụ necrotic),
• sistem lymphatic na ọbara: ugboro ugboro - anaemia (hemolytic ma ọ bụ aplastic), agranulocytosis, thrombocytopenia, purpura, leukopenia,
• sistem iku ume: n’akwụsịghị akwụsị - nnukwu akụkụ okuku ume na akwara, gụnyere ọrịa edere nke na-abụghị cardiogenic na pneumonitis,
• ụjọ ụjọ na psyche: ọtụtụ mgbe - isi ọwụwa, ugboro ugboro - ehighi ura,
• akụkụ anụ ahụ: oge ​​ụfọdụ - ịhụ ihe edo edo, mbelata ihe nlere anya nwa oge,
• usoro akwara:
• Usoro urinary: ugboro ugboro - akwara akwara, nephisic interstitial, ọnụnọ nke glucose na mmamịrị,
• anụ ahụ na akpụkpọ anụ subcutaneous: ugboro ugboro - ụgbụ ọkụ ọgbụgba, ọnya na-egbu egbu, necrolysis na-egbu egbu,
• usoro ahụ ji alụso ọrịa ọgụ: ọ dịkarịghị - mmeghachi omume anaphylactic dị iche iche (oge ụfọdụ ruo ujo),
• metabolism na oriri na-edozi: ugboro ugboro - anorexia,
• ulo nyocha na ihe omumu: okpukpu ugboro - mbelata nke mkpocha nke sodium na potassium na ọbara, mmụba nke uric acid n’ọbara, hyperglycemia,
• mmeghachi omume ndị ọzọ: oge ​​na - adịghị egbu egbu, ahụ ọkụ.

Dodoụbiga ya ókè

Site na mmachi nke Lozap gbakwunyere, a na-ahụ ihe mgbaàmà ndị a: n'ihi ọdịnaya nke losartan - bradycardia, tachycardia, mbelata ọbara mgbali elu n'ihi ọdịnaya hydrochlorothiazide - mfu nke electrolytes na akpịrị.

Treatmentụbiga ọgwụ ike ókè bụ ihe mgbaàmà. Ọ dị mkpa ịkwụsị ị theụ ọgwụ ahụ, hichaa afọ ma mee ihe iji bulie nguzo mmiri-electrolyte. Site na mmụba dị ukwuu na ọbara mgbali elu, a na-egosipụta ọgwụgwọ infusion mmezi. Usoro ọgwụgwọ iji wepụ losartan adịghị arụ ọrụ. Ogo ogo hydrochlorothiazide site na hemodialysis edobeghị.

Ntụziaka pụrụ iche

Dịka ntuziaka ahụ si dị, enwere ike iji Lozap Plus mee ihe n'otu oge na ọgwụ ndị ọzọ na - egbochi mkpali.

N'oge ọgwụgwọ, ọ dị mkpa ịchịkwa ọdịdị nke ihe ọ bụla mgbaàmà nke mebiri nke mmiri-electrolyte nguzo, na-etolite megide ndabere nke ọgbụgbọ na vomiting ma ọ bụ afọ ọsịsa. N'ime ndị ọrịa dị otu a, a ga-enyocha serum electrolytes kwa oge.

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Emebeghi ihe omumu puru iche banyere ogwu Lozap tinyere ikike nke uche mmadu. Agbanyeghị, ekwesịrị iburu n'uche na n'oge ọgwụgwọ ọgwụ ọgwụ antihypertensive, karịsịa na mmalite ọgwụgwọ, ụra ma ọ bụ nkụchi nwere ike ime, nke nwere ike imetụta ọnụego mmeghachi omume na ịta.

Ime na lactation

Ọgwụ ndị na-emetụta usoro renin-angiotensin bụ nke a machibidoro maka iji nke atọ na nke atọ nke afọ ime, ebe ha nwere ike ibute ọnwụ nwa ebu n’afọ. Mgbe afọ ime, Lozap gbakwunyere kwesịrị ịkwụsị.

A naghị atụ aro ịhọpụta ọrịa diuretics maka ụmụ nwanyị dị ime, ebe ọ nwere nnukwu ihe egwu nke jaundice na nwa ebu n'afọ na nwa amụrụ ọhụrụ, yana thrombocytopenia na nne.

Lozap gbakwunyere na-emegide ụmụ nwanyị na-agwọ ọrịa, ebe ọ bụ na thiazides nwere ike ibute nnukwu diuresis na gbochie ịmịpụta mmiri ara ehi.

Mkparịta ụka ọgwụ ọjọọ

Iji Lozap na-emekọ ihe ọnụ na ya na ọgwụ ndị na-eme ka mmiri ọgwụ, ọgwụ nwere ọgwụ ma ọ bụ ọgwụ nwere ihe dochie maka nnu nnu, anaghị atụ aro (ịbawanye ọkwa nke potassium na ọbara ga-ekwe omume).

Losartan na-eme ka ọgwụgwọ ọgwụgwọ nke ọgwụ ndị ọzọ belata ọbara mgbali elu. Onweghi mmekorita ogwu nke di na losartan nwere cimetidine, ketoconazole, hydrochlorothiazide, phenobarbital, erythromycin, anticoagulants na digoxin na adighi anaghi ama.

Site na iji thiazide diuretics na ọgwụ ụfọdụ n’otu oge, enwere ike ịhụ mmekorita ndị a:

• ọgwụ hypoglycemic nke na-ahụ maka nchịkwa ọnụ na insulin - nwere ike ịchọ nhazi ego nke edepụtara,
• ethanol, narcotic analgesics, barbiturates - ihe isi ike nke hypotension postural (orthostatic) mụbara,
• adrenocorticotropic homonụ, corticosteroids - ọnwụ nke electrolytes, ọkachasị potassium, na-eme ka ọwanyewanye
• Ngwakọta lithium - ihe ize ndụ nke ịhiụ mmanya na-abawanye ụba,
• colestyramine, colestipol - a na - ebelata mmiri hydrochlorothiazide,
• ọgwụ mgbochi na - abụghị ọgwụ steroidal - enwere ike belata ọrịa diuretic, hypotensive na natriuretic nke diuretics,
• pressor amines (adrenaline, wdg) - a na-ahụ ntakịrị mbelata na mmetụta ha,
• ndị na - anaghị eme ka akwara dị jụụ (tubocurarine chloride, wdg) - enwere ike ịkwalite ọrụ ha,
• probenecid, allopurinol, sulfinpyrazone - nwere ike ịchọ ndozi nke ọgwụ ndị a,
• salicylates - ọ ga - ekwe omume ịbawanye uto na-egbu egbu nke salicylates na sistemụ akwara dị,
• ọgwụ cytotoxic - enwere ike ịkwalite mmetụta myelosuppressive ha,
• cyclosporine - enwere ike bụrụ nsogbu nke gout na ihe egwu dị elu nke hyperuricemia,
• methyldopa - a hụrụ ihe ndị metụtara hemolytic anaemia,
• anticholinergics - mmụba na bioavailability nke hydrochlorothiazide ga-ekwe omume,
• ọgwụ ọgwụ ndị ọzọ na - egbochi ihe ike - enwere ike ịhụ ihe mmetụ ahụ.

Analogs nke Lozapa gbakwunyere bụ: Lozartan, Lozartan-N Canon, Lozartan-N Richter, Lorista, Lorista N, Lorista N 100, Lakea, Lozarel, Cozaar, Centor, Presartan.

Nyocha na Lozap Plus

Dabere na nyocha, Lozap Plus bụ ọgwụ dị irè iji belata ọbara mgbali elu. Ndị ọrịa rịbara ama na ọ bụghị naanị na ọ na - enyere aka na mgbali elu akwara, kamakwa na - egbochi mmepe nke ọrịa obi. Lozap Plus na-ebelata nrụgide ngwa ngwa ma na-arụ ọrụ n'ehihie. N'ime uru ọgwụ dị, ntụkwasị obi ya, ịdị mfe nke iji ya (otu ugboro n'ụbọchị), enwere mmetụta dị nfe na nchekwa.

Ọdịmma ọghọm nke ọgwụ ahụ na ụfọdụ nyocha gụnyere nsonaazụ nke Lozap gbakwunyere nwere ike ịkpata, yana eziokwu ahụ bụ na ọgwụ ahụ dị irè naanị iji oge niile. Patientsfọdụ ndị ọrịa na-eme mkpesa maka ọnụ ahịa ya dị elu (ọ bara uru ịzụta ọgwụ na nnukwu nchịkọta).

Leasedị mwepụta, ihe mejupụtara na nkwakọ

Ọgwụ a "Lozap gbakwunyere" bụ nke otu ọgwụ antihypertensive. N'akụkụ nke ọzọ, ndị a bụ mbadamba edo edo ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke na-acha ọcha, ọdịdị ya. Ihe nkiri na-ekpuchi ọgwụ. E nwere warara n’akụkụ abụọ nke mbadamba nkume ndị ahụ. N’otu purupọ pịrị 10 ma ọ bụ 15, na-etinye ya na kaadiboodu. Mbadamba ụrọ Lozap nwere ihe ọrụ abụọ na-arụ ọrụ - potassium losartan na hydrochlorothiazide. Mbadamba ụrọ ha nwere 50 mg na 12.5 mg, n'otu n'otu. Ihe inyeaka bu:

Ihe ngosi maka oge atọrọ

Ntụziaka maka ojiji na-ekwu na enwere ike iji "Lozap Plus" dị ka ọgwụ dị iche na ọgwụgwọ ma ọ bụ dịka njikọta na usoro ọgwụgwọ siri ike. Tupu iji, gwaa dọkịta gị. Ọ dị mma ịtụle na "Lozap" na "Lozap gbakwunyere" nwere ihe fọrọ nke nta ka ọ bụrụ otu mmetụta na ọgwụgwọ. Ihe ngosi maka ojiji bu:

• mmụba dị elu nke ọbara mgbali elu nke ụdị ma ọ bụ nke oge,
• dị ka akụkụ nke ọgwụgwọ na ọgwụgwọ nke ọrịa obi na-adịghị ala ala,
• dika mgbochi nke oria obi agha,
• na ngosipụta nke ọrịa shuga na ọbara mgbali elu.

Ntụziaka maka ojiji na ị doụ ọgwụ nke "Lozap gbakwunyere"

Ofzọ nke itinye ya n'ọrụ na usoro ọgwụgwọ akwadoro bụ ihe dị iche Lozap na Lozap Plus. Ọ ga-abụ ihe ziri ezi ị drinkụ mbadamba 1 (50 mg nke losartan) kwa ụbọchị. Onweghi nri nri. Ọ bụrụ n’ofe oge, nrụgide ahụ anaghị ada ka ihe mmadụ chọrọ, usoro a kwesiri ịba ụba. Ọ dị mma ịghara ị moreụ karịa mbadamba 2 kwa ụbọchị. Nke a juputara na nsonaazụ ahụike. Iji gbochie ọrịa obi, o zuru oke ị takeụ ọgwụ 1 kwa ụbọchị. Ọ bụrụ na dọkịta depụtara Lozap 100, ọkara mbadamba ụbọchị kwa ụbọchị (50 mg) ezuola. Tupu ịmalite ọgwụgwọ, ịkwesịrị ịgakwuru dọkịta ma nyocha.

Ndakọrịta ọgwụ

Ọgwụ "Lozap Plus" ka ndị dọkịta depụtara ka ọ bụrụ mgbakwunye na usoro ọgwụgwọ bụ isi. ọ dị mkpa ịtụle ndakọrịta na mmekorita nke ihe ndị nọ n'ọrụ. Onye rụpụtara na-egosi nsonazụ losartan na ọgwụ ọgwụ ndị ọzọ na nkọwapụta. Site na nhazi oge a na ọgwụ ọgwụ antihypertensive, nrụgide ahụ na-agbadata ngwa ngwa. A na-achọpụta ọkwa dị elu karịa potassium mgbe ejikọtara ya na ndị nwere potassium. A na-ahụ mbelata mmetụta ahụ mgbe ejikọtara ya na ọgwụ mgbochi ọgwụ mgbochi na - abụghị ọgwụ steroidal. Amachibido mbido onwere iji ọtụtụ ọgwụ n'otu oge.

Ime na lactation

Amachibidoro "Lozap Plus" ma ọ bụ "Lozap" n'oge afọ ime. Nke a bụ eziokwu karịsịa maka ụmụ nwanyị na-eme atụmatụ ime na ọnwa atọ mbụ ha ịmụ nwa. Nke a bụ n'ihi mmetụta ọjọọ nke ihe ndị mejupụtara nwa ebu n’afọ. Losartan nwere ike ịbanye na mmiri ara. Maka nke a, a ga-akwụsị iri nri mgbe a na-agwọ ya. Can nwere ike inyeghachi nwatakịrị ahụ nri afọ 2 ka ị naturalụsịrị ikpeazụ.

Childrenmụaka na agadi

Amachibidoro ihe ruru afọ 18 ka ewere “Lozap Plus”. Onye rụpụtara ya dọrọ aka ná ntị banyere ihe ize ndụ nke mbanye. Maka ndị ọrịa agadi, usoro ọgwụgwọ mbụ bụ 50 mg kwa ụbọchị. N'okwu a, ị ga na-elebara ọdịmma gị anya mgbe niile ma na-eme nyocha ụlọ nyocha. Ọ bụrụ na arụghị ọrụ, ọgwụ a kwesiri ịgbanwe ya ka ọ bụrụ ọgwụ yiri ya.

Maka nsogbu akụrụ na imeju

Ejiri "Lozap gbakwunyere" wee kpachara anya ma ọ bụrụ na arụ ọrụ imeju na-erughị 9 na ọkwa nke Child-Pugh. Ọgwụ a abụghị ihe karịrị 1 ọgwụ kwa ụbọchị. Site na mmepe nke ọrịa imeju, amachibidoro oriri. Ọrịa dị iche iche na - arụ ọrụ nke akụkụ ahụ nke usoro akwara ahụ na - achọ nlezianya ịhọrọ nke ogo na oge ọgwụgwọ. Ihe dị mkpa bụ ileba anya na mmamịrị ụlọ nyocha.

Ngwọta ndị yiri ya

Ọ bụrụ na enwere ọgwụ mgbochi ọgwụ "Lozap Plus" ma ọ bụ ọ bụrụ na enweghi ya na ụlọ ahịa ọgwụ, ịkwesịrị ịhọrọ onye dochie anya. N'okwu a, ngwá ọrụ kwesịrị ịdị otu a na mbụ, ebe a na-etinye onye ọrịa ahụ kpamkpam. Nhọrọ a bụ nke dibịa nọ n'ụlọ na-eburu n'uche akụkọ gbasara ahụike nke onye ọrịa. Ndị ga-anọchi anya ha bụ Cardomin, Co-Centor, Losartan, Lorista, Nostasartan, Logzartik Plus, Kandekor na Valsartan.

Ihe ngosi maka ojiji

A na-atụ aro ka Lozap Plus dị ka akụkụ nke usoro ọgwụgwọ mgbagwoju anya nke ọbara mgbali elu akwara na ndị ọrịa maka ụdị ọgwụgwọ a kachasị mma. A na-a drugụ ọgwụ ahụ maka ọbara mgbali elu na ọbara mgbali aka ekpe iji belata ihe ize ndụ nke ịmalite ọrịa obi na onwu.

Ntuziaka maka iji Lozap Plus: usoro na usoro onunu ogwu

A na-ewere ọnụ ederede Lozap Plus, n'agbanyeghị oge nri.

Usoro a tụrụ aro ka usoro ọgwụgwọ si dị:

• Ọbara mgbali elu: ịmalite na mmezi ahụ ike - 1 mbadamba ụbọchi, na enweghị ike ịnweta oke ọbara ọgbụgba, enwere ike ịbawanye ọgwụ ahụ rue mbadamba 2 kwa 1 oge kwa ụbọchị, a na-enweta ike hypotensive nke ọgwụ ahụ n'ime izu atọ site na mmalite ọgwụgwọ,
• mbelata n'ihe ize ndụ nke ọrịa obi na ọrịa obi na ndị ọrịa nwere ọbara mgbali elu na mkpụrụedemede aka ekpe: leftmalite nke losartan bụ 50 mg / ụbọchị, na enweghị njide zuru oke yana ọkwa ọbara mgbali elu na losartan monotherapy, njikọta losartan na hydrochlorothiazide na obere ala chọrọ ( 12.5 mg), nke ọgwụ Lozap Plus na-agbagha, ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ọgwụ ahụ gaa mbadamba 2 kwa oge 1 kwa ụbọchị (100 mg nke losartan + 25 mg nke hydrochlorothiazide).

Na arụ ọrụ imeju

Dabere na ọmụmụ ọgwụ pharmacookinetic na ndị ọrịa nwere ọrịa cirrhosis, a na-achọpụta mmụba dị ukwuu na mkpokọta plasma nke losartan. Thiazide diuretics, gụnyere hydrochlorothiazide, nwere ike ibute cholestasis intrahepatic, na obere ọgba aghara na nguzo mmiri-electrolyte nwere ike ịkpalite mmepe nke hepatic coma. Na njikọ a, ejiri Lozap Plus dozie ya anya ma ọ bụrụ na arụ ọrụ imeju na-arịa ya (gụnyere akụkọ ihe mere eme) ma ọ bụ ọrịa ọrịa na-aga n'ihu. Na mmebi siri ike nke ọrụ imeju, a na-egbochi ọgwụ a.

Hydrochlorothiazide

• barbiturates, mmanya, opioid analgesics, antidepressants: ihe ọghọm nke orthostatic hypotension na-abawanye,
• ọgwụ antidiabetic (insulin na hypoglycemic na-elekọta mmadụ maka nchịkwa ọnụ): hydrochlorothiazide na-enwe ike imetụta ndidi glucose ha, nke nwere ike ịchọ mmezi dose,
• metformin: mmepe nke lactic acidosis ga-ekwe omume, n'ihi ụkọ akụrụngwa nke arụ ọrụ n'ihi ojiji hydrochlorothiazide, ekwesịrị ịkpachara anya mgbe ejikọtara ọnụ,
• ọgwụ ndị ọzọ na - egbochi mmiri, synergies nke ihe na - eso na mmepe nke mmata,
• colestyramine, colestipol: ion-resins resins na-egbochi nnabata nke hydrochlorothiazide, otu ọgwụ colestyramine / colestipol na - eduga na njikọ nke hydrochlorothiazide ma belata ntinye ya na eriri afọ site na 85% / 43%,
• corticosteroids, hormone adrenocorticotropic (ACTH): nwere ike ịkawanye ụkọ electrolytes, karịsịa hypokalemia,
• pressor amines (adrenaline): ikekwe mbelata nke ihe, na ewezuga ihe eji ha.
• ihe ndị na - adịghị eme ka ike gwụ abụba (tubocurarine chloride): hydrochlorothiazide nwere ike ịkwalite mmetụta ha,
• njikere nke lithium: diuretics, tinyere hydrochlorothiazide, belata mkpocha ụlọ, na-abawanye ihe egwu nke lithium, a na-atụ aro iji otu oge ahụ,
• ọgwụ mgbochi-gout (sulfinpyrazone, probenecid, allopurinol): enwere ike ịchọ ndozi nke usoro, ebe hydrochlorothiazide nwere ike ịbawanye ọkwa seric uric acid, ọ nwere ike ịbawanye ngosipụta nke mmeghachi omume nfụkasị allopurinol,
• ọgwụ anticholinergic (atropine, biperidine): nwere ike iwelie bioavailability nke hydrochlorothiazide n'ihi mgbochi nke eriri afọ na mbelata ọnụọgụ gastric.
• cytotoxins (methotrexate, cyclophosphamide): ọ ga-ekwe omume igbochi ezumike ha site na akụrụ ma welie mmetụta myelosuppressive,
• salicylates: mgbe ejiri ya na oke doses, mmetụta ha na-egbu egbu na sistemụ akwara (CNS) nwere ike ịba ụba
• methyldopa: a kọwara ihe dị iche iche na mmepe nke ana - akpọ hemolytic
• cyclosporine: ohere dị ala nke hyperuricemia na nsogbu nke gout,
• Cardiac glycosides: hypokalemia / hypomagnesemia nke hydrochlorothiazide nwere ike itinye aka na mmepe nke arrhythmias na-akpata digitalis,
• digitalis glycosides, antiarrhythmic ọgwụ (nke ọgwụgwọ ọgwụgwọ nke nke na-adabere na serum potassium larịị), klas IA antiarrhythmic ọgwụ (hydroquinidine, quinidine, viopyramide), klas III antiarrhythmic ọgwụ (amiodarone, dofetilide, ibutilide, sotalol), antipro , trifluoperazine, cyamemazine, sultopride, sulpiride, amisulpride, pimozide, tiapride, droperidol, haloperidol), ọgwụ ndị ọzọ nwere ike ime ka ventricular tachycardia nke ụdị pirouette (difemanil, bepridil, cisapride, erythromycin intravenously, halofantrine, pentamidine, misolastine, terfenadine, vincamycin intravenously): a na-atụ aro ka ị na-enyocha ọkwa potassium mgbe niile, ebe ọ bụ na hypokalemia bụ ihe na-ebute mmepe nke pyruet tachycardia cardio, na ihe nlele nke ECGa (ECTV), na-eleba anya nke ECTV
• nnu nnu: hydrochlorothiazide nwere ike iwelite ọkwa nke calcium na serum n’ihi mbelata ya, ọ chọrọ nlebara anya nke ọkwa kalịum na ntụzi kwesịrị ekwesị nke usoro nke usoro calcium, n’ihi nsonaazụ calcium, hydrochlorothiazide nwere ike imegharị nsonaazụ nke ntule ọrụ parathyroid,
• carbamazepine: nlere anya nyocha na nyocha ụlọ nyocha nke ọkwa sodium ọbara dị na ndị ọrịa na-eji carbamazepine dị mkpa, n'ihi ihe egwu nke ịmalite hypoatremia symptomatic,
• iodine nwere ihe dị iche n’etiti: na mmiri na - eme ka akpịrị na - akpata mmiri, ihe ize ndụ nke ịmalite ịrịa oke akụrụ na-abawanye, ọkachasị mgbe ị na - akwado iodine na oke doses, ya mere a chọrọ mmiri ọkụ tupu nchịkwa.
• amphotericin B (parenteral), glucocorticosteroids, ọgwụ ACTH na-akpali akpali ma ọ bụ glycyrrhizin (nke a chọtara na licorice): hydrochlorothiazide nwere ike ibute ụkọ electrolyte, karịchaa hypokalemia.

Ihe analogues nke Lozap Plus bụ: Gizaar, Gizaar Forte, Hydrochlorothiazide + Lozartan TAD, Blocktran GT, Lozarel Plus, Lozartan-N Canon, Lozartan N, Lozartan / Hydrochlorothiazide-Teva, Presartan N, Lorista N 100, Lorista N, Siman Nd.

Nyocha na Lozap Plus

Ndị ọrịa họọrọ Lozap Plus iweda nrụgide ha na-ahapụ nyocha dị mma. Ha dere na ị were mbadamba mbubreyo otu ụbọchị kwa ụbọchị na-eme ka ọdịmma ka ọ dị mma, na-ebelata nrụgide, na-akwụsị nkụda mmụọ. Fọdụ na-enwe nchegbu banyere mmetụta ọrịa diuretic nke ọgwụ ma nwee mmasị na ọ nwere mmerụ ahụ site na iji ogologo oge.

A na-amanye ndị ọrịa nwere ebumnuche ịhapụ Lozap Plus ọgwụ, ebe ọ bụ na a na-egbochi ọgwụ mkpịsị ụkwụ n'oge ọ na-achịkwa, ma ọ bụ jiri usoro ọgwụ ndị ọzọ na - egbochi ọgwụ mgbochi ọzọ.

Lozap gbakwunyere: ntuziaka maka ojiji (usoro na usoro)

A na-ewere ọnụ iji Lozap gbakwunye mbadamba, n'agbanyeghị oge nri.

Ihe ngosi a tụrụ aro:

• ọbara mgbali: usoro mbido na mmezi - 1 mbadamba kwa ụbọchị. Ọ bụrụ na enweghị mmetụta n'ụdị iji nweta ọkwa ọbara mgbali zuru oke, enwere ike ịbawanye ọnụọgụ abụọ ka mbadamba abụọ otu ugboro n'ụbọchị. A na - enweta mmetụta kachasị hypotensive n'ime izu 3 mgbe mmalite nke ọgwụgwọ,
• ọbara mgbali ọbara na ogwe aka nke ventricular hypertrophy - iji belata ihe egwu nke ibute ọrịa obi na ọnwụ: ọgwụ mbụ losartan bụ 50 mg otu ugboro n'ụbọchị. Ọ bụrụ na, na nzụlite nke monotherapy na losartan, ọ gaghị ekwe omume iru ọkwa mgbaru ọsọ ọbara, ọ dị mkpa ịhọrọ usoro nkwonkwo nke losartan na hydrochlorothiazide na obere ala (12.5 mg). Ọ bụrụ na ọ dị mkpa, enwere ike ịba ụba nke losartan na 100 mg / ụbọchị yana mgbakwunye hydrochlorothiazide na dose nke 12.5 mg / ụbọchị. N'ọdịnihu, ọ ga - ekwe omume ịbawanye ọgwụ a kacha karịa - 2 mbadamba Lozap gbakwunyere otu ugboro n'ụbọchị.

Na arụ ọrụ ezumike ọrụ

Dịka ntuziaka ahụ si dị, ekwesịrị iji Lozap gbakwunyere na ndị ọrịa nwere akwara akwara Stenosis ma ọ bụ akụrụ akwara Stenosis nke otu akụrụ, yana ndị ọrịa agbanyela mmegharị akụrụ.

Enwere ihe akaebe banyere mmepe nke ọdịda akụrụ n'ihi mgbochi nke losartan site na sistemụ renin-angiotensin-aldosterone na ndị ọrịa nwere nnukwu obi nkụda mmụọ ma ọ bụ nwee nkwarụ dị ugbu a. Losartan nwere ike iwelie mmụba nke urea na creatinine na plasma ọbara n'ime ndị ọrịa nwere akwara mkpụrụ ndụ akwara Stenosis ma ọ bụ na akụrụ akwara nke otu akụrụ. Mgbanwe na ọrụ akụrụ nwere ike ịgbanwee ma belata mgbe ịkwụsị ịcontụ ọgwụ ọjọọ.

Ebumnuche nke Lozap gbakwunyere maka nsogbu akụrụ oke (mwepụ nke okike erughi 30 ml / min).