Ofloxacin: ntuziaka maka ojiji > Ọgwụgwọ na mgbochi

Mbadamba ọgwụ nke Ofloxacin so na ọgwụ ọgwụ nje ọgwụ ọgwụ nje. A na-eji ha maka ọgwụgwọ etiotropic (ọgwụgwọ nke chọrọ ibibi pathogen) nke ọrịa na-efe efe nke microorganisms na-emetụta akụkụ ahụ ọgwụ ahụ.

Mwepụta wepụtara ya na ihe mejupụtara

Ofloxacin mbadamba osisi na-acha ọcha na agba, gburugburu na udi ma nwee biconvex elu. Ejiri ihe mkpuchi ihe nkiri kpuchie ha. Ofloxacin bu isi ihe eji eme ogwu ahu; ihe di n'ime ya bu mbadamba 200 na 400 mg. Ọzọkwa, ihe mejupụtara ya gụnyere ihe inyeaka, nke gụnyere:

Microcrystalline cellulose.
Colloidal silicon dioxide.
Povidone.
Ọka ọka.
Talc.
Calcium stearate.
Propylene glycol.
Hypromellose.
Titanium dioxide
Macrogol 4000.

Mkpokọta Ofloxacin dị mbadamba na paịlị 10. Mpempe kaadiboodu nwere otu ọnya ahụ nwere mbadamba na ntụziaka maka iji ọgwụ ahụ.

Omume ọgwụ

Ihe dị n’ime mkpụrụ ndụ Ofloxacin mbadamba inhibits (inhibits) nje mkpụrụ ndụ nke enzyme DNA gyrase, nke na-ejide mmeghachi omume nnwale nke DNA (deoxyribonucleic acid). Ọnụnọ nke mmeghachi omume dị otú a na-eduga na enweghị ike nke nje bacteria na-esote ọnwụ mkpụrụ ndụ. Ọgwụ nwere mmetụta nke ọgwụ nje (na-eduga na ọnwụ nke mkpụrụ ndụ nje). Ọ na-ezo aka na ihe ndị na-egbochi nje ihe dị iche iche. Bacteriamụ nje ndị a

Staphylococci (Staphylococcus aureus, staphylococcus epidermidis).
Neisseria (Neisseria gonorrhoeae, Neisseria meningitidis).
E. coli (Escherichia coli).
Klebsiella, tinyere Klebsiella pneumoniae.
Proteus (Proteus mirabilis, Proteus vulgaris, gụnyere indole-positive and indole-strains strain).
Pathogens nke ọrịa eriri afọ (Salmonella spp., Shigella spp., Gụnyere Shigella sonnei, Yersinia enterocolitica, Campylobacter jejuni, Aeromonas hydrophila, Plesiomonas aeruginosa, Vibrio cholerae, Vibrio parahaemolyticus).
Pathogens nwere usoro mbufe mmekọahụ kacha - - Chlamydia - Chlamydia spp.).
Legionella (Legionella spp.).
Pathogens nke pertussis na pertussis (Bordetella parapertussis, Bordetella pertussis).
Ihe na - ebute ihe otutu bụ propionibacterium acnes.

Agbanwe uche na-arụsi ọrụ ike mgwa Ofloxacin mbadamba nwere Enterococcus faecalis, streptococcus pyogenes, streptococcus pneumoniae, streptococcus viridans, Serrratia marcescens, pseudomonas aeruginosa, Acinetobacter spp., Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacterium ụkwara nta, Mycobacteriurn fortuitum, Ureaplasma urealyticum, Clostridium perfringens, Corynebacterium spp ., Helicobacter pylori, Listeria monocytogenes, Gardnerella vaginalis. Nocardia asteroides, nje nje anaerobic (Bacteroides spp., Peptococcus spp., Peptostreptococcus spp., Eubacterium spp., Fusobacterium spp., Clostridium difficile) anaghị enwe mmetụta na ọgwụ ahụ. Ọrịa syphilis, Treponema pallidum, na-eguzogidekwa nke ofloxacin.

Mgbe iwere Ofloxacin mbadamba nkume n'ime, onye na-arụ ọrụ na-ngwa ngwa ọ fọkwara obere ka eriri afọ banye na akụkụ eriri afọ. A na-ekesasị ya na akwara nke ahụ. Ofloxacin nwere obere metaraoli imeju (ihe dị ka 5% nke mkpokọta ịta ahụhụ). A na-ewepụ ihe dị na mmamịrị na mmamịrị, ruo na nnukwu mgbanwe adịghị. Ọkara ndụ (oge ọkara nke ọgwụ ahụ dum na ahụ ya) bụ awa 4-7.

Ihe ngosi maka ojiji

Ngosiputa nke mbadamba osisi nke Ofloxacin bu otutu onodu oria ojoo a na akpata site na nje na anakpo ndi oria pathogenic.

Ọrịa na ọrịa ọnya nke akụkụ nke ENT - sinusitis (ọnya nje nke paranasal sinuses), pharyngitis (mbufụt nke pharynx), otitis media (mbufụt nke etiti ntị), tonsillitis (ọrịa nje nke tonsils), laryngitis (mbufụt nke ogwooro).
Ọrịa na - efe efe nke ala akụkụ okuku ume na - bronchitis (mbufụt nke bronchi), ka oyi baa (oyi baa).
Ọkpụkpụ na-emebi akpụkpọ ahụ na anụ ahụ dị nro site na nje dị iche iche, gụnyere mmepe nke usoro purulent.
Ọrịa na - efe efe nke nkwonkwo na ọkpụkpụ, gụnyere poliomyelitis (purulent ọnya anụ ahụ).
Ọrịa na-efe efe na usoro mkpaghasị nke usoro digestive na usoro nke usoro ịba ọcha n'anya.
Pathology nke akụkụ ahụ pelvic na ụmụ nwanyị nke nje dị iche iche kpatara - salpingitis (mbufụt nke oghere fallopian), endometritis (mbufụt nke mucosa uterine), oophoritis (mbufụt nke ụmụ oke), parametritis (mbufụt ke mpụta oyi akwa nke mgbidi uterine), cervicitis (mbufụt nke cervix).
Ọrịa ọnya nke akụkụ ahụ dị n’ime nwoke bụ prostatitis (mbufụt nke gland), orchitis (mbufụt nke testicles), epididymitis (mbufụt nke ngwa nke testes).
Ọrịa na-efe efe na ọnya na - ebutekarị nwanyị - gonorrhea, chlamydia.
Ọrịa na - efe efe nke akụrụ na akwara na - pyelonephritis (purulent mbufụt nke calyx na renal pelvis), cystitis (mbufụt nke ọnya), urethritis (mbufụt nke urera).
Ọkpụkpụ na-efe efe nke membranes nke ụbụrụ na eriri azụ (meningitis).

A na-ejikwa mbadamba ọgwụ Ofloxacin iji gbochie ọrịa nje nje ndị ọrịa nwere obere ọrụ ọrụ nke sistem na-alụso ọrịa ọgụ.

Ihe ngbanwe

Nlekọta nke mbadamba osisi Ofloxacin na-egbochi ọsịtọ na ọnọdụ akụrụngwa nke anụ ahụ, nke gụnyere:

Hypersensitivity na ihe na-arụ ọrụ na ihe enyemaka nke ọgwụ.
Akwụkwụ na-adọ (oge ụfọdụ nke ihe ọdịdọ tonic-clonic siri ike n ’ime ọnọdụ mmetụ uche dị ụnyaahụ, gụnyere oge gara aga.
Ihe ga - eme mkpụmkpụ nke ihe ọdịdọ (na - agbadata oghere ọdịdọ) megide nzụlite mmerụ ahụ ụbụrụ na - akpata mkpasu iwe, ihe na - egbu mmụọ nke akụkụ akwara dị ya n’ahụ, yana ụbụrụ ụbụrụ.
Undermụaka na-erubeghị afọ 18, nke a na-ejikọ ya na imebi ọkpụkpụ ọkpụkpụ ezughị ezu.
Ime ime n’oge ọ bụla nke itolite na ịra nwa (na-enye nwa ara).

N'iji nlezianya mee, a na-eji mbadamba mkpụrụ osisi Ofloxacin maka atherosclerosis (itinye cholesterol na mgbidi akwara) nke arịa ụbụrụ, nsogbu ụbụrụ na-emetụta ụbụrụ (gụnyere ndị bufere ya n'oge gara aga), ọnya anụ ahụ nke akụkụ nke sistemụ akwara etiti, yana mbelata na-adịghị ala ala na arụ ọrụ nke imeju. Tupu ị takingụ ọgwụ ahụ, ị ga-agba mbọ hụ na enweghi ọgwụ mgbochi.

Usoro onunu ogwu na nhazi

Mpempe akwụkwọ nke Ofloxacin na-ewerezi nri dum tupu ma ọ bụ mgbe nri gasịrị. A areụchaghị mmiri ma sachaa ha. Usoro ịsụ ọgwụ na usoro ojiji nke ọgwụ ahụ na-adabere na pathogen, yabụ, ọ bụ ndị dibia bekee kpebisiri ya ike. Nkezi onwa ogwu a di 200-800 mg kwa ubochi n’ime onwa abuo abuo, usoro ochichi di iche n’etiti ubochi asaa rue iri (nkea igwo oria urinary nke ana akaghi aru, ihe eji aru ya gwo oria nwere ike ihe ubochi ato nke 3-5). A na-ewere mbadamba nke Ofloxacin na ọgwụ mgmịn 400 mg otu oge maka ọgwụgwọ gonorrhea. Maka ndị ọrịa nwere mbelata nke arụ ọrụ akụrụ na imeju, yana ndị nke metụtara akwara ọbara (ịdị ọcha ọbara nke ngwaike), idozi usoro ọgwụgwọ dị mkpa.

Nsonaazụ

Nlekọta nke mbadamba osisi Ofloxacin nwere ike iduga mmepe nke mmeghachi omume ojoo site na akụkụ na sistem dị iche iche:

Usoro nri - ọgbụgbọ, ọgbụgbọ, oge agụụ, agụụ, ruo na ọnụnọ ya zuru oke (anorexia), afọ ọsịsa, flatulence (bloating), mgbu afọ, ịba ụba nke imeju transaminase enzymes (ALT, AST) n'ime ọbara, na-egosi mmebi nke mkpụrụ ndụ imeju. jalestice cholestatic jaundice kpasuru iwe site na sitena nke anakpo hepatobiliary sistem, hyperbilirubinemia (ọnụọgụ bilirubin n'ọbara), ọnya pseudomembranous enterocolitis (ọrịa mkpali nke nje bacteria ana-akpọ Clostridi Um difficile).
Usoro ụjọ na akwara anụ ahụ - isi ọwụwa, ọgbụgbọ, enweghị ntụkwasị obi na mmegharị, ọkachasị metụtara mkpa nka dị mma, ịma jijiji (ịma jijiji) nke aka, oge oge dị iche iche nke akwara mkpụrụ obi, ọnya akpụkpọ ahụ na paresthesia ya (ọnya nwere mmetụta), ụra abalị, iyi egwu dị iche iche. (ụjọ na-atụ egwu ihe ma ọ bụ ọnọdụ dị iche iche), nchegbu, ịba ụba nke ike ụbụrụ, ịda mba (mgbadata ihu ogologo oge), ọgba aghara, ihe ngosi ma ọ bụ nyocha okwu, sihoticheskie mmeghachi omume, diplopia (abụọ ọhụụ), isi ọhụụ (nke agba) ụtọ, ísì, na-anụ, itule, mụbara intracranial nsogbu.
Ọkpụkpụ akwara - tachycardia (obi ịba ụba), vasculitis (mmeghachi omume mbufụt nke arịa ọbara), ida (mbelata akara ụda olu akwara).
Ọbara ọbara na akwara ọbara - mbelata nke ọnụ ọgụgụ ọbara ọbara ọbara (hemolytic ma ọ bụ aplastic anaemia), sel ọbara ọcha (leukopenia), platelet (thrombocytopenia), yana ọnweghị ezi ọrụ nke granulocytes (agranulocytosis).
Usoro ure - interstitial nephritis (mmeghachi azụ nke akụrụ), arụ ọrụ akụrụ, mmụba urea na creatinine n'ime ọbara, nke na-egosi mmepe nke ọdịda akụrụ.
Usoro akwara - mgbu mgbu (arthralgia), akwara ọkpụkpụ (myalgia), mmegharị ahụ akwara (tendivitis), akpa nkwonkwo syndrome (synovitis), mkpọchi ụkwara ahụ.
Ihe ndi mejuputara - petechiae (akpukpo arusi di n’akpo), dermatitis (mbufụt nke aru), oria papular.
Mmeghachi omume nfụkasị ahụ - ọnya anụ ahụ, itching, hives (njirimara ọkụ na ọzịza nke anụ ahụ na - adị ka ọnụnụ ụgbụ), bronchospasm (nfe nke bronchi n'ihi spasm), pneumonitis nfụkasị (oyi ịba), fever fever (fever), angio Isi mkpirisi Quincke (akụkụ oke akụkụ nke akụkụ ihu na akụkụ ahụ nke akụkụ ya), mmeghachi ahụ anụ ahụ necrotic (Lyell, Stevens-Johnson syndrome), nsogbu anaphylactic ure (nnukwu sistemu ụbụrụ. mmeghachi omume nwere mbelata ọbara mgbali elu na mmepe nke ọtụtụ akụkụ ahụ).

Ọ bụrụ na mmepe nke nsonaazụ ndị ọzọ mgbe ịmalite ojiji nke mbadamba Ofloxacin, gọọmentị ha kwesịrị ịkwụsị ma kpọtụrụ dọkịta. Ohere iji ọgwụ ọzọ were were, ọ na-ekpebi n’otu n’otu, dabere n’ụdị na ogo ọghọm ya.

Ntụziaka pụrụ iche

Tupu ịmalite ịre mbadamba nke Ofloxacin, ị kwesịrị ị na-agụ nke ọma iji kọwaa ọgwụ ahụ. Enwere ọtụtụ ntuziaka pụrụ iche ị kwesịrị ị paya ntị na:

Ọgwụ a abụghị ụzọ nhọrọ maka ọgwụgwọ nke oyi oyi nke pneumococcus na nnukwu tonsillitis.
N'oge ị drugụ ọgwụ ahụ, i kwesịrị izere ikpughere anụ ahụ na ìhè anyanwụ ma ọ bụ radieshon ultraviolet.
A naghị atụ aro ka ị illsụọ ọgwụ ihe karịrị ọnwa 2.
N'ihe banyere mmepe nke enterocolitis pseudomembranous, a na-ewepụ ọgwụ ahụ, a na-atụkwa ọgwụ metronidazole na vancomycin.
Mgbe ị na-ewere mbadamba nke Ofloxacin, mbufụt nke akwara na akwara nwere ike ịmalite, mmetụ mgbawa (karịchaa akwara Achilles) ọbụlagodi obere ibu.
N ’ime ihe banyere iji ọgwụ ahụ eme ihe, a naghị atụ aro ka ụmụ nwanyị jiri tampons n’oge ọbara ọgbụgba n’ihi oke ike nke imepe candidiasis (isiji) nke ahịhịa na-enye ohere.
N'ihe banyere ihe ụfọdụ ga - eme, mgbe iwere Ofloxacin mbadamba, myasthenia gravis (ike ọgwụgwụ) nwere ike ịmalite.
Ductmalite usoro nchọpụta banyere njirimara nke ihe kpatara ọrịa ụkwara nta n'oge eji ọgwụ ahụ nwere ike ibute nsonaazụ ụgha na-adịghị mma.
N'ihe banyere conalitantal renal ma ọ bụ ọrịa ịba ọcha n'anya, ọ dị mkpa iji nyocha mkpebi nke ụlọ nyocha nke oge nke ndị na-egosi ọrụ ha, yana ntinye nke ọgwụ na-arụ ọrụ.
Zere ị alcoholụ mmanya mgbe ị na-a theụ ọgwụ.
A na-eji ọgwụ ahụ maka ụmụaka eme ihe naanị maka ọgwụgwọ nke ọnọdụ ndị na-eyi ndụ egwu nke ọrịa na-efe efe na-akpata.
Ihe dị n’arụ ọrụ nke mbadamba ọgwụ Ofloxacin nwere ike imekọrịta na ọnụ ọgụgụ dị ukwuu nke ọgwụ dịgasị iche iche nke ọgwụ ọgwụ ndị ọzọ, ya mere, a ga-adọ dọkịta ha aka ná ntị banyere iji ha.
N'oge a na-eji ọgwụ ahụ eme ihe, ọ dị mkpa ịhapụ ọrụ metụtara ya na mkpa maka itinye uche nlebara anya na ọsọ nke mmeghachi omume psychomotor, ebe ọ na-emetụta ọrụ ọrụ nke ụbụrụ ụbụrụ.

Na netwọsị ahịa ọgwụ, mbadamba ọgwụ Ofloxacin dị na ndenye ọgwụ. Ewepụrụ onwe ha maka na-enweghị ndenye ọgwụ kwesịrị ekwesị.

Dodoụbiga ya ókè

N'ihe banyere oke ịgwọ ọrịa ọgwụ ọgwụ ọgwụ Ofloxacin na-atụ aro, ọgba aghara na-amalite, ọgbụgbọ, ọgbụgbọ, ura, enweghị uche na ohere. Ọgwụ nke ịdoụbiga ihe ókè mejupụtara bụ ịsacha akwara nri, na ị ,ụ ọgwụ ụkwara, ma na-eduzi usoro ọgwụgwọ Symptomatic n'ụlọ ọgwụ.

Usoro onunu ogwu na nhazi

Doctorlọ ọrụ ahụ wee họrọ usoro na usoro ọgwụ dị n'ụdị mbadamba ihe na ihe mgbochi infusion, dabere n'ịdị ọcha nke ọrịa ahụ yana ọnọdụ ya, yana na ọnọdụ onye ọrịa ahụ, nnabata microorganisms, yana imeju na akụrụ ọrụ.

N'ime ndị ọrịa nwere ọrụ mgbazinye nsogbu na nhichapụta nke creatinine (CK) nke 20-50 ml / min, otu mkpụrụ ego bụ 50% nke akwadoro (ugboro ole nchịkwa ugboro abụọ kwa ụbọchị), ma ọ bụ na-ewere otu ọgwụ zuru ezu otu oge kwa ụbọchị. Na QC