Baeta - ntuziaka gọọmentị maka ojiji

Mpempe usoro onunu ogwu - ihe omuma nke ochichi subcutaneous (s / c): na-akowaputa, enweghi odo odo (1.2 ma obu 2.4 ml na katriiki nke etinyere na mkpirisi sirinji, na ngwugwu kaadiboodu edeputara 1 nke edere na ntuziaka maka ojiji nke Bayeta).

Ngwakọta nke 1 ml nke ihe ngwọta:

• ihe na-arụ ọrụ: exenatide - 250 mcg,
• ihe inyeaka: metacresol, mannitol, acetic acid, sodium acetate trihydrate, mmiri maka ịgba ntụtụ.

Mlọ ọgwụ

Ihe na-arụ ọrụ nke Baeta bụ exenatide - aminopeptide 39-amino acid, nnabata nke ndị na-anabata polypeptide glucagon.

Ọ bụ ihe dị ike nke na - akpọ gluptagon-dị ka peptide-1 (GLP-1), nke na - eme ka ọrụ nke β-sel dịkwuo elu, na - eme ka mmiri ọgwụ glucose ghara ịba ụba, na - eme ka glucagon dịkwuo ala, belata akụrụngwa na - egbu egbu (mgbe ịbanye na eriri afọ ahụ na oke ọbara). nwere mmetụta hypoglycemic ndị ọzọ. Ya mere, exenatide nwere ike melite njikwa glycemic na ụdị shuga nke 2.

Usoro amino acid nke exenatide ruo n’ókè dabara adaba na usoro nke mmadụ GLP-1, n’ihi ọgwụ a na-ejikọ ndị nabatara GLP-1 ma mee ka ha rụọ ọrụ. N’ihi nke a, a na-eme ka njikọta glucose na-egbochi glucose na secre-sel nke pancreas site na ntinye nke cyclic adenosine monophosphate (AMP) na / ma ọ bụ ụzọ mgbaàmà intracellular ndị ọzọ. Exenatide na-akwalite mwepụta nke insulin site na mkpụrụ ndụ β-sel inwetara n’oru glucose.

Exenatide dị iche n'ụdị kemịkalụ na usoro ọgwụ si na alfa-glucosidase inhibitors, sulfonylureas, insulin, biguanides, meglitinides, thiazolidinediones na usoro D-phenylalanine.

Usoro ndị a na-eme ka nchịkwa glycemic dị n'ụdị nke 2 dị mma:

• Ihe nzuzo insulin insulin na-adabere: exenatide na-eme ka mmiri ọgwụ insulin na-emetụta glucose site na mkpụrụ ndụ panc-pancreatic na ndị ọrịa nwere ọnọdụ hyperglycemic. Ka ọkwa glucose dị n’ọbara na-ebelata, mmiri ọgwụ insulin na-ebelata, mgbe ọ bịaruru n’usoro, ọ kwụsịrị, si otú a belata ihe ọghọm hypoglycemia,
• usoro mbu nke nzaghachi insulin: na ụdị ọrịa shuga abụọ nke ọrịa shuga, ọ nweghị ọgwụ insulin ọ bụla na nkeji iri mbụ. Na mgbakwunye, ọnwụ nke usoro a bụ nkwarụ mbụ nke ọrụ β-cell. Ojiji nke exenatide weghachi ma ọ bụ kwalite akụkụ nke mbụ na nke abụọ nke nzaghachi insulin,
• glucagon zoro ezo: a bụrụ nke hyperglycemia, exenatide na-egbochi oke ikuku glucagon, ebe ọ naghị emebi nzaghachi glucagon nkịtị na hypoglycemia,
• iri nri: exenatide na-ebelata agụụ na, maka nke a, ọnụọgụ nri riri,
• gastric emptying: igbochi gastric motility, exenatide na-eme ka ọ kwụsịlata.

Ojiji nke exenatide ụdị 2 ọrịa shuga mellitus na mgbakwunye thiazolidinedione, usoro metformin na / ma ọ bụ sulfonylurea na-enyere aka belata ọbara glucose na-ebu ọnụ na ọbara mgbatị postprandial, yana hemoglobin A1c (Hb_A1c), nke na - eme ka njikwa glycemic dịkwuo mma.

Mlọ ọgwụ

Mgbe sc nlekọta, a na-etinye exenatide ngwa ngwa. Nkezi kacha itinye uche (C_max) enwetara n’ime awa 2.1 ma bụrụkwa 211 pg / ml.

Mpaghara dị n'okpuru usoro ịta ahụhụ (AUC) mgbe sc nchịkwa nke exenatide na dose 10 μg - 1036 pg × h / ml, ihe ngosi a na-abawanye na nha ka mmụba ahụ, mana ọ naghị emetụta C_max. Etuputara otu mmetụta a na ntinye aka nke Baeta n'ubu, afọ ma ọ bụ n'apata ụkwụ.

Olu nke nkesa (V_d) ihe ruru 28.3 lita. Ọ bụ nke kachasị site na nzacha zuru ụwa ọnụ ma na - eso mbibi proteolytic. Mkpochapu ahụ bụ ihe dịka 9.1 l / h. Oge ndụ ikpe-azụ ikpeazụ (T_½) - awa 2.4 Nke ọgwụ ọgwụ egosirighị ọgwụ dabere na ya.

A na-ekpebi mkpokọta elekere dị ka elekere 10 ka nchịkwa nke exenatide.

Pharmacokinetics n'ọnọdụ ndị pụrụ iche:

• arụ ọrụ ezigharị arụmọrụ: jiri obere mkpanaka nrụpụta creatinine (CC) 30-80 ml / min, ọdịiche dị ukwuu na ọgwụ ọgwụ nke exenatide adịghị achọpụta, ya mere, achọrọ nhazigharị dose. N'ime ndị ọrịa nwere ọrịa ọgbụgba akụrụngwa n'ọgwụgwụ, ha na -ebilata ọgwụ iji ruo 0.9 l / h (na ndị ọrịa nwere ahụike - 9.1 l / h),
• Ọrụ imeju na - arụ ọrụ: achọpụtabeghị ọdịiche dị ukwuu na mkpokọta plasma nke exenatide, ebe ọ bụ na akụrụ ya bụ nke akụrụ na-apụkarị
• afọ: a gụrụghị ọgwụ pharmacokinetics nke exenatide na ụmụaka, na ndị nọ n'afọ iri na abụọ na 16 ruo afọ iri abụọ na ọrịa shuga mellitus, mgbe ị na-eji exenatide na ọgwụ nke 5 μg, ekpughere ọgwụ ọgwụ dịka nke ndị ọrịa okenye, na ndị agadi anaghị enwe mgbanwe na njirimara pharmacokinetic, ya mere, mgbanwe ndozi abụghị chọrọ
• okike na agbụrụ: a hụghị ọdịiche dị ukwuu na ọgwụ ọgwụ nke exenatide n'etiti ụmụ nwanyị na ụmụ nwoke, agbụrụ ahụ enweghị mmetụta pụtara ìhè na oke a,
• Ikpa ahu ahu: onweghi nkwekorita di egwu di n’etiti ahu uka n’enweghi ogwu na ebe ndi nlebara anya n’ego achoputara.

Ihe ngosi maka ojiji

Dịka ọgwụ monotherapy maka ụdị shuga 2, a na-eji Bayete na mgbakwunye na usoro ọgwụgwọ nri na mmega ahụ iji nweta njikwa glycemic zuru ezu.

Na usoro njikọta nke ụdị ọrịa shuga 2 na-arịa ọrịa shuga, a na-eji Bayete aka mma nchịkwa glycemic n'ihe ndị a:

• na mgbakwunye na ngwakọta metformin / sulfonylurea / thiazolidinedione / metformin + na usoro nchịkọta + sulfonylurea / metformin + thiazolidinedione,
• na mgbakwunye na ngwakọta nke insulin insulin + metformin.

Mpempe usoro onunu ogwu

Ngwọta maka nchịkwa subcutaneous.

1 ml nke ihe ngwọta nwere:

ike ọrụ: exenatide 250 mcg,

ndị na-ebu ụzọ: sodium acetate trihydrate 1.59 mg, acetic acid 1.10 mg, mannitol 43.0 mg, metacresol 2.20 mg, mmiri maka injection q.s. ihe ruru 1 ml.

Ngwọta na-enweghị ntụpọ enweghị agba.

Isi izugbe nke ọgwụ

Ogwu Baeta bu ihe edozighi edozi nye infusionaneous infusion. Ihe na - arụ ọrụ nke ọgwụ ahụ bụ exenatide, ọ nwekwara obere nke sodium acetate trihydrate, metacresol, mannitol, acetic acid, mmiri distilled. Ha na-ahapụ ọgwụ ahụ n'ụdị ampoules (250 mg), nke ọ bụla nwere mkpụrụ edemede sirinji pụrụ iche nke nwere olu nke 1.2 na 2.4 ml.

Ndị ọrịa na-a drugụ ọgwụ a na-achọpụta mbelata ọbara shuga n'ihi usoro a:

1. Byeta na-eme ka mpụpụ nke insulin site na parenchyma nwee mmụba nke glucose na n'ọbara mmadụ.
2. Ihe nzuzo insulin na-akwụsị n’oge enwere ogo shuga.
3. Ihe ikpeazụ ị ga - eme bụ mee ka glucose ọbara gị sie ike.

N'ime ndị mmadụ na-arịa ụdị ọrịa shuga nke abụọ, ị ofụ ọgwụ ahụ na-eduga mgbanwe ndị dị otú a:

• Mgbochi ị productionụkọ glucagon, nke na - egbochi insulin.
• Mgbochi nke motility gastric.
• Agụụ agụụ.

Mgbe a na-achịkwa ọgwụ n'okpuru subcutaneously, ihe ahụ dị ike na-amalite ime ihe ozugbo wee ruo na arụmọrụ ya kachasị elu ka awa abụọ gasịrị.

Mmetụta ọgwụ ahụ na-akwụsị kpam kpam naanị mgbe ụbọchị gasịrị.

Ntuziaka maka iji ọgwụ ahụ

Naanị dibia na-aga ele anya nwere ike inye ọgwụ ọgwụ a, n'ọnọdụ ọdịmma ịchọrọ ị self were onwe gị. Mgbe ị nwetachara ọgwụ Baeta, a ga-eji nlezianya mụọ ntuziaka maka ojiji.

Ngosipụta maka iji ọgwụ a bụ ụdị ọrịa shuga 2 na-arịa ọrịa mono ma ọ bụ ọgwụgwọ. A na-eji ya mgbe ọ gaghị ekwe omume ịchịkwa ọkwa nke glycemia nke ọma. Enwere ike iji ọgwụ a jikọta ya na ụzọ ndị a:

1. Metformin
2. Thiazolidinedione,
3. eji eme udara sulfonylurea,
4. Nchikota metformin, sulfonylurea,
5. Nchikota metformin na thiazolidinedione.

Usoro onunu ogwu a bu 5 twiceg ugboro abuo otu ubochi tupu iwere isi nri. Etinye ya n'okpuru ukwu na ukwu aka, apata ụkwụ ma ọ bụ afọ. Mgbe otu ọnwa nke usoro ọgwụgwọ na-aga nke ọma, a na-amụba usoro ịba ụba ruo 10 mcg ugboro abụọ n'ụbọchị. Ọ bụrụ na ejiri ọgwụ a jikọta ya na usoro dị iche iche nke sulfonylurea, a ga-ebelata oke nke ikpeazụ iji zere ọnọdụ hypoglycemic nke onye ọrịa.

Iwu ndị a maka ị theụ ọgwụ a ga-ahụkwara.

• enweghi ike ijikwa ya mgbe nri gasịrị.
• ekwesighi igba igba intramuscularly or intraven,
• ọ bụrụ na ihe ngwọta ya dị urukpuru ma gbanwee agba, ọ ka mma iji ya,
• ma ọ bụrụ na achọtara ntụpọ ahụ, ịkwesịrị ịkagbu nchịkwa nke ọgwụ ahụ,
• n'oge ọgwụgwọ Bayeta, ọgwụ mmepụta ga-ekwe omume.

Ekwesịrị idobe ọgwụ a na ebe nchekwa na ìhè site na obere ụmụaka. Ekwesịrị ịchọpụta ọnọdụ nchekwa na oke site na ogo 2 ruo 8, yabụ ọ ka mma idobe ọgwụ na friji, mana ewepụla ya.

Ndụ nchekwa nke ngwaahịa ahụ bụ afọ 2, na azịza dị na mkpịsị sirinji bụ ọnwa 1 na-enweghị ogo 25.

Leasedị mwepụta, ihe mejupụtara na nkwakọ

O bu osisa nye ochichi. Na mkpịsị sirinji nwere ike ịbụ 1.2 ma ọ bụ 2.4 ml nke ihe na-arụ ọrụ. Ihe ngwugwu a nwere otu mkpụrụ sirinji.

Ihe mejupụtara ya gụnyere:

• exenatide -250 mcg,
• sodium acetate trihydrate,
• glaasi acetic acid,
• mannitol
• metacresol
• mmiri maka ịgba ntụtụ.

"Baeta Long" bụ ntụ ntụ maka ịkwadebe nkwusioru, nke erere na ihe jupụtara na ya. Ọnụ ego nke ụdị ọgwụ a dị elu, a na-ejikarị ya. A na-eji naanị subcutaneously.

Omume ọgwụ

Ọ nwere mmetụta hypoglycemic. N'ụzọ dị mkpa na-eme ka nchịkwa glucose ọbara dị elu, na-ebuli ọrụ nke mkpụrụ ndụ beta nke pancreatic, na-egbochi oke glucagon, na-eme ka mmiri insulin na-adabere glucose ma na-ebelata mgbaze gastric.

Exenatide dị iche na mejupụtara site na insulin, sulfonylurea na ihe ndị ọzọ, yabụ na-enweghị ike ịbụ nnọchi ha na ọgwụgwọ.

Ndị ọrịa na-a theụ ọgwụ Bayeta na-ebelata agụụ, na-akwụsịlata ibu, ma nwee ahụike nke ọma.

Ihe ngbanwe

• Hypersensitivity na mmiri,
• Ọrịa siri ike nke eriri afọ na gastroparesis na -akpọ,
• Akụkọ banyere ketoacidosis nke ọrịa mamịrị,
• Nnukwu gbasara akụrụngwa,
• Ọrịa shuga 1dị 1
• Ime na lactation
• Afọ n'okpuru afọ iri na asatọ.

Ntụziaka maka ojiji (usoro na usoro onunu ogwu)

A na-achịkwa ọgwụ n'okpuru subcutaneously n'ime afọ, ubu, hips ma ọ bụ buttocks. Ekwesịrị ịgbanwere ebe a na-agba ya mgbe niile. Na-amalite na usoro onunu ogwu nke 5 mcg ugboro abụọ kwa ụbọchị tupu nri. Inwere ike iwulite dose ahụ gaa na 10 mcg ugboro abụọ kwa ụbọchị mgbe izu anọ gachara, ọ bụrụ na egosiri. Site na ọgwụgwọ agbakwunyere, enwere ike ịhazigharị dose nke sulfonylurea na ọgwụ insulin.

Nsonaazụ

• Hypoglycemia (ya na usoro ọgwụgwọ ejikọtara),
• Agụụ agụụ
• Dyspepsia
• Gastroesophageal reflux,
• Ire uto,
• Ihe mgbu
• Nausea, vomiting,
• Ọrịa afọ ọsịsa
• Ntachi
• Ire
• Rowsjọ
• Dizziness
• Isi ọwụwa
• Mmeghachi omume nfụkasị sistemu,
• Mmeghachi omume nfụkasị mpaghara na saịtị ndị injection,
• Anaaflactic ujo,
• Hyperhidrosis,
• Akpịrị ịkpọ nkụ
• Nnukwu pancreatitis (adịkarịghị),
• Nnukwu akwara na-ada ada (obere).

Dodoụbiga ya ókè

Ihe mgbaàmà ndị a na-esote ị nwere ike ịdoụbiga ya ókè:

• Hypoglycemia. Ọ na-egosipụta onwe ya dịka adịghị ike, ọgbụgbọ na ọgbụgbọ, na -eme mmụọ nsụhọ ruo ọnwụ ya na mmepe nke coma, agụụ, ọgbụgbọ, wdg. N'ihe banyere hypoglycemia na-agafe agafe na nke siri ike, a ga-achọ ntụtụ nke glucagon ma ọ bụ ngwọta dextrose, mgbe ịbubatasịrị mmadụ ahụ - nri nwere carbohydrate. Gbalịsie ike ịkwado ndụmọdụ ahụ ka ị kpọtụrụ onye ọkachamara maka ndozi dose.
• Ọnọdụ siri ike, gụnyere ọgbụgbọ na ọgbụgbọ. A na-etinye ọgwụgwọ Symptomatic, ịga ụlọ ọgwụ ga-ekwe omume.

Mkparịta ụka ọgwụ ọjọọ

Kwesịrị ịgwa dọkịta gị ka ị discussụọ ọgwụ chọrọ nnabata ngwa ngwa site na eriri afọ, ebe “Baeta” na - ebelata afọ ime, n'ihi nke ọgwụ.

Ekwesịrị iji ọgwụ nje na ihe ndị yiri ya mee 1 awa tupu ntụtụ nke "Bayeta" ma ọ bụ n'oge nri ndị ahụ mgbe ejighị ọgwụ a.

Na-ebelata ịta nke digoxin, lovastatin, na-eme ka oge nke lisinopril na warfarin nwee ohere kachasị.

Na mkpokọta, enwere ike ịmụ ihe banyere mmetụta nke ọgwụ ndị ọzọ. Nke a apụtaghị na ụfọdụ ndị na-egosipụta ndụ na-ama ama n'oge nchịkwa. Ya mere, a na-atụle ajụjụ nke ijikọ ọgwụgwọ Bayetoy na ọgwụ ndị ọzọ n'otu n'otu na dibịa bekee.

Ntụziaka pụrụ iche

Emeghị ya mgbe ị risịrị nri. Abanyela na intraven ma obu intramuscularly.

Ọ bụrụ nkwụchi na nsogbu ma ọ bụ ọgba aghara, ekwesighi iji ọgwụ ahụ.

Achọpụtara ya n’ozi ọgwụ na ọgwụ na-emetụta oke ahụ, na -ebelata agụụ.

Ejighị ya na ndị nwere nnukwu akwara.

O nwere ike ibute oria akwara, ma o nweghi nsogbu oria.

Onye ọrịa ahụ kwesịrị nyochaa mgbanwe ahụike ha n'oge usoro ọgwụgwọ. Site na mmepe nke ọnọdụ nnukwu, ị kwesịrị ịkpọtụrụ dọkịta ozugbo wee kwụsị ị .ụ ya.

Ejighi ya dochie anya insulin.

Mgbe ejikọtara ya na metformin ma ọ bụ sulfonylurea, ọ nwere ike imetụta ike ịnya ụgbọ. Gị na dọkịta gị doziri okwu a.

EGO. A na-enye ọgwụ ahụ naanị site na ndenye ọgwụ!

Jiri na nwata na nká

Enweghị data maka mmetụta ọgwụ nwere n'ahụ ahụ ụmụaka ruru afọ 18, ya mere, ejighị ya maka ọgwụgwọ ha. Agbanyeghị na enwere ahụmịhe eji eme ihe n’ebe ụmụaka nọ site n’afọ iri na abụọ, ihe ndị na-egosi ọgwụgwọ ahụ dị ka ndị okenye Mana ọtụtụ mgbe a na-edenye ụzọ ndị ọzọ.

Nwere ike iji gwọọ ọrịa shuga na ndị ọrịa agadi. Agbanyeghị, ịkwesịrị nyochaa ọnọdụ nke ndị ahụ nwere akụkọ ntolite ketoacidosis ma ọ bụ ndị nwere ọrụ ezumike na ọrụ ha. A na-adụ ndị ọrịa dị otú ahụ ọdụ ka ha nwalee ule oge niile.

Tụnyere ọgwụ ndị yiri ya

Ọgwụ a dị oke ọnụ nwere ọgwụ analogues nwekwara ike iji gwọọ ọrịa shuga. Ka anyị leba anya n'ihe ha nwere.

Iji ọgwụ analogues kwere omume naanị site n'ikike nke dọkịta na-abịa. Amachibidoro ị medicationụ onwe gị ọgwụ!

Ndị mmadụ na-achọpụta na mmetụta ndị ọ na-adịkarị anaghị ewerekarị, ọkachasị na-eji usoro eji eme ya emeghị nke ọma. Etupụtara nsonaazụ nke oke ibu, ọ bụ ezie na ọ bụghị n'ọnọdụ niile. Na mkpokọta, “Bayeta” nwere ezigbo nyocha nke ndị ọrịa mamịrị nwere ahụmịhe.

Alla: “Ejiri m ọgwụ ahụ kemgbe afọ abụọ.N'oge a, shuga laghachiri nkịtị, ịdị arọ ya belatara 8 n'arọ. Enwere m mmasị na ọ na-arụ ọrụ ngwa ngwa na enweghị nsonaazụ. Ana m adụ gị ọdụ. ”

Oksana: “Baeta” bu ọgwụgwọ di oke ọnụ, mana ọ na - enyere ọrịa shuga aka. Sugar na-emekwa otu ọkwa, nke m nwere obi ụtọ. Enweghị m ike ịsị na ọ na-ebelata ibu dị oke mkpa, mana ọ dịkarịa ala, akwụsịrị m ịgbake. Mana agụụ agụụ na-achịkwa n'ezie. Achọrọ m iri ihe na-erughị, ya mere ibu ibu ogologo oge n'otu oge ahụ. N'ozuzu, enwere m afọ ojuju na ọgwụ a. ”

Igor: “Ha depụtara ọgwụ a maka ọgwụgwọ mgbe ọgwụ ọgwụ ochie m kwụsịrị ịnagide. Na mkpokọta, ihe niile dabara adabara, belụsọ maka ọnụahịa dị elu. Enweghị ike inweta "Bayetu", ịkwesiri ịkwado tupu oge eruo. Nke a bụ naanị nsogbu. Achọghị m ka m jiri ihe analogues ma, mana ọ ga-ekwe ọnụ. Ọ bụ ezie na enwere m ike ịmata na ahụrụ m mmetụta ahụ ngwa ngwa - naanị izu ole na ole mgbe mmalite nke dose ahụ. Agụụ ahụ belatara, ya mere o felatara otu mgbe. ”

Mmechi

"Baeta" bụ ọgwụ dị irè nke a ma ama n'etiti ndị ọrịa nwere ọrịa shuga. A na-edekarị ya mgbe ọgwụ ndị ọzọ kwụsịrị ime ihe. Ọnụ ego dị elu na-ewute site na nsonaazụ ọzọ nke oke ibu na ngosipụta na - adịghị ahụkebe ihe ọ bụla na - emetụta ndị ọrịa na - agwọ ọrịa. Ya mere, “Bayeta” na-abụkarị nyocha dị mma site na ndị na-eji ọgwụ na ndị dọkịta.

Ihe ngosi na contraindications

Ekwuputara na ịdị irè nke ọgwụ ahụ na nnwale 6 na-enweghị usoro nke ejiri otu mkpụrụ ọgwụ exenatide (2 mg) tụnyere ọgwụ ndị ọzọ. Ọmụmụ ihe ndị a metụtara ndị natara ọgwụgwọ maka ọrịa shuga (nri + mmega ahụ, mgbe ụfọdụ yana ọgwụgwọ ahụike). Ndị ọrịa nwere HbA1c nke dị n'agbata 7.1 na 11% yana otu anụ ahụ kwụsiri ike nke nwere BMI nke 25 ruo 45 n'arọ / m2.

Ntụnche abụọ mepere emepe nke ọgwụ ahụ were izu iri atọ ma ọ bụ iri abụọ na anọ. Onu ogugu ndi mmadu 547, kariri 80% nke were metformin na sulfonylurea ma obu pioglitazone, sonyere na omumu. Nkwado ntọhapụ kwụrụ ụgwọ nyere nsonaazụ kacha mma n'ihe banyere HbA1c: HbA1c belatara 1.9% na 1.6%, otu ọ bụla.

N'ime ọmụmụ nke kpuru ìsì nwere izu iri abụọ na isii, ndị ọkà mmụta sayensị ji sitagliptin, pioglitazone, na exenatide. Ọmụmụ ihe ahụ metụtara mmadụ 491 na-anabataghị ọgwụgwọ na metformin. Mgbe ejiri ya ọgwụ exenatide, ntinye uche nke HbA1c belata site na 1.5%, nke dị elu karịa nke pioglitazone na sitagliptin. Mgbe ị na-ewere "Bayeta", ịhịa aka n'ahụ belatara site na 2.3 n'arọ.

A na - egbochi ọgwụ ahụ n'oge afọ ime na lactation. Ọ bụrụ n’atụmatụ ịtụrụ ime, ekwesịrị ịkwụsị ọgwụ a ọbụlagodi ọnwa atọ. Ndị ọrịa na-erubeghị afọ 18 enweghị ike iji ngwaahịa a n'ihi na amụtaghị ya na otu ọgbọ a. Na ọdịda akụrụngwa, enwere ọghọm nke mmetụta ndị ọzọ. Ndị ọrịa nwere nhichapụ ihe dị n'okpuru 30 ml / min ekwesịghị ịnara ọgwụ.

Ọgwụ ọ dị mkpa ka a nye ya naanị otu izu n’ike. N’aka nke ọzọ, ọgwụ na - agbanye n’ime ahụ ma ọ dịkarịa ala izu iri nwekwara ike ịba ụba maka nsogbu dị ogologo.

Mmekorita

Exenatide nwere ike ịmetụta oke ọgbụgba, oke na ogo nke ọgwụ ndị ọzọ. Medicationụ ọgwụ nwere ike ịbawanye ohere ịba ụba hypoglycemia mgbe ị na-a insụ insulin na sulfonylurea. Egosiwo ojiji ojiji ọgwụ ịticụ ọgwụ ọnụ na-ebelata ọgwụ coagulation.

Isi analogues (ya na ihe ndi yiri ya) nke ogwu:

Echiche nke onye ọrịa na dọkịta banyere ọgwụ.

Dọkịta tiri ọgwụ ọgwụ, maka ọgwụ ndị ọzọ arụghị ọrụ. Ekwesịrị m ikwu ozugbo - ngwá ọrụ dị oke ọnụ. Aghaghị m ịzụta ọtụtụ ngwugwu, nke na-efu ọnụ ego. Agbanyeghị, nsonaazụ ahụ kwesịrị ọnụ ahịa - ọnọdụ ahụ ka ọ dịla ọfụma. Enweghị m mmetụta ọjọọ ọ bụla. Mita ahụ na-egosi ụkpụrụ nkịtị maka ọtụtụ ọnwa.

“Baeta” bụ ọgwụ dị oke ọnụ ka edepụtara maka arụ ọrụ nke ọgwụ mgbochi ọgwụ ndị ọzọ. Ogologo oge (dika ihe ndi isi ochichi) siri di, na - ebelata glycemia ma mekwaa onodu ndi oria, n’agbanyeghi “odi ire”.

Boris Alexandrovich, diabetologist

Ọnụahịa (na Russian Federation)

Ọnụ ego ọgwụgwọ bụ 9000 rubles maka izu anọ. Antụ ọgwụ antidiabet ndị ọzọ dị ọnụ ala karịa, metformin (mkpokọta, 2 g / ụbọchị) na-erughị 1000 rubles kwa ọnwa.

Ndụmọdụ! Tupu ịzụta ọgwụ ọ bụla, ekwesịrị ịgakwuru ọkachamara a zụrụ azụ. Medication medicationụ ọgwụ n'echeghị echiche nwere ike ibute nsonaazụ na-enweghị atụ na oke mmefu ego. Dọkịta ga - enyere aka idepụta usoro ọgwụgwọ dị mma ma dị irè, yabụ na akara mbụ ịkwesịrị ịchọ enyemaka ahụike.

Ọnụ ego ọgwụ ọjọọ na nyocha

Enwere ike ịzụta ọgwụ ọgwụ Baeta na ụlọ ahịa ọ bụla ma ọ bụ tinye iwu n'ụlọ ahịa ọgwụ n'ịntanetị. Ekwesịrị iburu n'uche na ọ bụ naanị ndenye ọgwụ ka erere ọgwụ a. Ebe ọ bụ na onye mepụtara ngwaahịa a bụ Sweden, dika ọnụahịa ya dị elu.

Yabụ, ọ bụghị ndị nkịtị niile nwere ọrịa shuga nwere ike ịzụrụ ụdị ọgwụ a. Ego dịgasị iche dabere n'ụdị ntọhapụ nke ego:

• Pen sirinji 1.2 ml - site na 4246 ruo 6398 rubles,
• Mkpịsị mkpụrụ sirinji nke 2.4 ml - site na 5301 ruo 8430 rubles.

Na-adịbeghị anya duziri nnyocha ahịa, nke ndị ọrịa ejiri ọgwụ a họrọ n'onwe ya wee gaa. N'izo aka na ogwu Byeta, onye nyocha ya na-egosiputa ọnụnọ nke nsonaazụ ọjọọ ndị a:

1. Nmebi nke usoro ụjọ ahụ: ike ọgwụgwụ, ịgwagbu ma ọ bụ enweghị ụtọ.
2. Mgbanwe na metabolism na nri: oke ibu, akpịrị ịkpọ nkụ n'ihi ọgbụgbọ.
3. O bu ihe nwudiri nke mmeghachi omume anaphylactic.
4. Ọgba aghara na ọnya na-akpata: mmụba gas na-akpata, afọ ntachi, nnukwu ọrịa ụjọ (mgbe ụfọdụ).
5. Mgbanwe mgbanwe nke urination: arụ ọrụ na-arụ ọrụ na-arụ ọrụ abawanye, ọkwa creatinine dị elu, ọdịda akụrụ ma ọ bụ ihe ya na-akawanye njọ.
6. Mmeghachi omume akpụkpọ ahụ Allergic: alopecia (ntutu isi), itching, urticaria, angioedema, maculopapular rashes.

N'ezie, isi ihe na-adịghị mma bụ ọnụ ahịa ọgwụ dị elu, ọ bụ n'ihi nke a ka ọtụtụ ndị ọrịa nwere ọrịa shuga na-ahapụ nyocha ha na Internetntanetị. Mana, na agbanyeghị nke a, ọgwụ a nwere oke belata ogo nke glucose n'ọbara onye ọrịa ma na - enyere aka ịlụso oke ibu.

Ọzọkwa, n'ihi ịdị iche iche nke ọgwụgwọ ọgwụgwọ ya, ọ naghị ebute ọgụ hypoglycemia.

Analogues nke ọgwụ

N'ihe banyere mgbe enweghi ike ịgwọ onye ọrịa ahụ ma ọ bụ nwee mmetụta na-adịghị mma, dọkịta na-ahụ maka ịga nwere ike ịgbanwe usoro ọgwụgwọ. Nke a pụtara n'ụzọ abụọ - site n'ịgbanwe oke nke ọgwụ ma ọ bụ hapụ ya kpamkpam. N'okwu nke abụọ, ọ dị mkpa ịhọrọ ọgwụ analog ga-enwe otu ọgwụgwọ ahụ ma ghara imerụ ahụ mamịrị ahụ.

Dika odi, Baeta enweghi uzo ozo. Naanị ụlọ ọrụ AstraZeneca na Bristol-Myers Squibb Co (BMS) na-ewepụta analogues 100% nke ọgwụ a (mkpụrụ ndụ ihe nketa). E nwere ụdị ọgwụ ọgwụ abụọ dị na ahịa ọgwụ Russia, nke dị na mmetụta ọgwụgwọ ha. Ndị a gụnyere:

1. Victoza bụ ọgwụ nke, dịkwa ka Baeta, bụ ọgwụ a na-ahụ anya. A na-emepụta ọgwụ ahụ n'ụdị mkpụrụ ọgwụ sirinji maka infusus subcutaneous infusions n'ụdị shuga nke 2. The Theụ ọgwụ ahụ mgbe niile na-enyere aka belata ọ̀tụ̀tụ̀ hemoglobin glyciko ruo 1.8% ma tufuo kilogram 4-5 ọzọ n’afọ ọgwụ. Okwesiri iburu n’uche na nani otu dọkịta nwere ike ichoputa izi ezi nke otu ogwu. Ọnụ ego ha ruru (pensụ 2 nke 3 ml) bụ 10,300 rubles.
2. Januvia bu ihe omimi riri nne nke na-ebelata shuga obara n’egwude oria nke abuo. Ọ dị n'ụdị mbadamba. Ọnụ ego otu ọgwụ (mkpụrụ 28, 100 mg) bụ 1672 rubles, nke bụ ọnụ ala n'etiti ọgwụ ndị a na-ekwu. Ma ajụjụ nke usọbọ ka mma iwere dị na ike nke dọkịta.

Yabụ, ọgwụ Bayeta bụ ọnya hypoglycemic dị irè. Mmetụta ọgwụgwọ ya nwere ụfọdụ njirimara na-enyere aka nweta njikwa glycemic zuru ezu. Agbanyeghị, ọgwụ ahụ n'ọnọdụ ụfọdụ enweghị ike iji ya rụọ ọrụ, ọ nwekwara ike ibute nsonaazụ na-adịghị mma.

Ya mere, ị -ụ ọgwụ onwe gị ekwesighi ya. Ọ dị mkpa iji mee njem gaa na dọkịta nke nyochara mkpa ọ dị ị theụ ọgwụ ahụ, na-eburu n'uche njirimara anụ ahụ nke onye ọrịa ọ bụla. Site na iji usoro onunu ogwu ziri ezi ma na-agbaso iwu niile maka iwebata ihe a ga - eme, ị nwere ike belata shuga n'ọkwa nkịtị wee wepụ ihe mgbaàmà hyperglycemia. Vidio dị n’isiokwu a na-ekwu okwu banyere ọgwụ shuga.

Ngwongwo ogwu

Exenatide (Exendin-4) bụ gluonagon dị ka polypeptide receptor agonist ma bụrụkwa amidopeptide 39-amino acid. Ihe ndị metụtara, dị ka gluptagon-dị ka peptide-1 (GLP-1), na-eme ka insulin na-adabere na glucose dị mma, na-arụ ọrụ beta cell, na-ebelata glucagon nke ukwuu na-ebelata ma belata gastric empt mgbe ha batara n'ọbara ọbara n'ozuzu ya na eriri afọ. Exenatide bụ ọgwụ dị ike n'ụdị nke na-eme ka mmiri ọgwụ insulin na-adabere na glucose ma nweekwa mmetụta hypoglycemic dị iche iche maka incretins, nke na-eme ka nchịkwa glycemic na ndị ọrịa nwere ụdị shuga 2.

Usoro amino acid nke exenatide na-adabakarị na usoro nke mmadụ GLP-1, n'ihi nke ọ na-ejikọ ma na-eme ka ndị na-anabata GLP-1 na mmadụ, nke na-eduga n'ịba ụba njikọta glucose na nzuzo nke insulin sitere na mkpụrụ ndụ beta nke pcunized na ntinye cyclic AMP na / ma ọ bụ ihe mgbaàmà intracellular ndị ọzọ. ụzọ. Exenatide na-akpali ntọhapụ nke insulin site na mkpụrụ ndụ beta na ọnụnọ nke ụba glucose. Exenatide dị iche n'ụdị kemịkalụ na ihe ọgwụ na-arụ na insulin, n'ụkpụrụ sulfonylurea, usoro D-phenylalanine na meglitinides, biguanides, thiazolidinediones na alfa-glucosidase inhibitors.

Exenatide na-eme ka nchịkwa glycemic dịkwuo mma na ndị ọrịa nwere ọrịa shuga nke 2 n'ihi usoro ndị a.

Ọ bụ insulin insulin na-a :ụrị: na ọnọdụ hyperglycemic, exenatide na-eme ka mmiri ọgwụ glucose na-emetụta glucose na sel beta pancreatic. Ihe nzuzo insulin a na-akwụsị ka ịba ụba nke glucose n'ọbara na-ebelata ka ọ na-erukwa ihe kwesịrị ekwesị, si otú a belata ihe egwu nwere ike ịrịa hypoglycemia.

Usoro mbu nke nzaghachi insulin: Inyocha insulin n'oge nkeji iri mbụ, a maara dị ka “ngalaba mbụ nke nzaghachi insulin”, enweghị ndị ọrịa bu ụdị shuga 2. Na mgbakwunye, mfu nke akụkụ mbụ nke nzaghachi insulin bụ nkwarụ mbụ nke ọrụ mkpụrụ ndụ beta na ọrịa shuga nke 2. Nlekọta nke exenatide weghachiri ma ọ bụ kwalite nke ọma na nke mbụ na nke abụọ nke nzaghachi insulin na ndị ọrịa nwere ụdị shuga 2.

Glucagon nzuzo: n'ime ndị ọrịa nwere ụdị ọrịa shuga 2 nke mellitus megide mmalite nke hyperglycemia, nchịkwa nke exenatide na-egbochi oke ikuku glucagon. Agbanyeghị, exenatide anaghị egbochi nzaghachi glucagon nkịtị na hypoglycemia.

Nri oriri: nchịkwa nke exenatide na-ebute mbelata agụụ na mbelata iri nri.

Gastric efu: egosiputara na nlekọta nke exenatide na egbochi mgbochi moti, ma ọ na - egbulata ịbelata. N'ime ndị ọrịa nwere ụdị ọrịa shuga 2 nke mwepu, ọgwụ exenatide na monotherapy yana ijikọ aka na nkwadebe metformin na / ma ọ bụ sulfonylurea na-eduga na mbelata ọbara glucose na-ebu ọnụ, postprandial ọbara glucose, yana HbA1c, si otú a na-emeziwanye nchịkwa glycemic na ndị ọrịa a.

Mlọ ọgwụ

Mgbe ọchịchị subcutaneous gasịrị nye ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa obi, a na-anakpo exenatide ngwa ngwa ma rute ngụkọta nke plasma kachasị mgbe awa 2.1 gachara. Nkezi nkezi ịta (Cmax) bụ 211 pg / ml yana mpaghara niile dị n'okpuru usoro ịta ahụhụ (AUC)_0-int) bụ 1036 pg x h / ml mgbe nchịkwa subcutaneous nke dose 10 μg exenatide. Mgbe ekpughere ya na exenatide, AUC na-abawanye na nha maka usoro ịrị elu site na 5 μg ruo 10 μg, ebe enweghị mmụba dị na Cmax. A hụkwara otu mmetụta ahụ na nchịkwa subcutaneous nke exenatide n'ime afọ, apata ụkwụ ma ọ bụ ubu.

Olu nke nkesa exenatide mgbe nchịkwa subcutaneous bụ 28.3 lita.

Metabolism na ntụpọ

Exenatide bụ nke kachasị kpochapu ikuku site na ịba ụba nke proteolytic. Nwepu nke Exenatide bụ 9.1 l / h yana ọkara ndụ ikpeazụ bụ awa 2.4. Omume ọgwụ ndị a na-enye ọgwụ nke exenatide anaghị akwụ ụgwọ onwe ha. A na-ekpebi mkpokọta nke exenatide kpebie ihe dịka elekere 10 mgbe ituchara.

Ndị otu ọrịa pụrụ iche

Ndị ọrịa nwere ọrụ mgbazinye nsogbu

N'ime ndị ọrịa nwere obere mkpo ya na-arụ ọrụ dị mkpirikpi (mwepu nke 30-80 ml / min), iwepụ ihe dị iche na mkpochapu ya na isiokwu ndị nwere ọrụ mkpo nkịtị, ya mere, a chọghị ịgbanwe ọgwụ a. Agbanyeghị, n'ime ndị ọrịa nwere ọrịa ọgbụgba akụrụngwa n'ọgwụgwụ, ha na-agbadata ịhapụ 0.9 l / h (ma e jiri ya tụnyere 9.1 l / h n'ihe ọmụmụ siri ike).

Ndị ọrịa nwere ọria imeju

Ebe ọ bụ na exenatide bụ akịrị ewepu akụrụ, ekwenyere na ọrụ ịba ọcha n'anya anaghị agbanwe oke mkpocha ọbara n'ime ọbara. Ndị agadi Afọ anaghị emetụta njikwa ọgwụ nke ọgwụ exenatide. Ya mere, achoghi ndi okenye aruru agadi ka ha mee mmeghari ogwu.

Childrenmụaka Emebeghị ka ọgwụ ụlọ ọgwụ nke exenatide na ụmụaka.

Ndị dị afọ iri na ụma (afọ 12 ruo 16)

Na nyocha nke pharmacokinetic nke emere ndị ọrịa nwere ụdị ọrịa shuga 2 dị afọ iri na abụọ ruo afọ iri na isii, nchịkwa nke exenatide na nha nke 5 μg sokwa ọgwụ ọgwụ ahụ yiri ndị a hụrụ na ndị okenye.

Enweghị ọdịiche dị oke mkpa dị n'etiti ụmụ nwoke na ụmụ nwanyị na ọgwụ ọgwụ nke exenatide. Ọsọ Race enweghi mmetụta di egwu na pharmacokinetics nke exenatide. Ndozigharị ndabere sitere na agbụrụ agbụrụ adịghị achọrọ.

Ndị ọrịa Obese

Onweghi nkwekorita di omimi n'etiti aruchi aru (BMI) na exenatide pharmacokinetics. Mgbanwe dose dabere na BMI.

NWA ANYA

Baxter Pharmaceutical Solutions ELC, USA
927 South Curry Pike, Bloomington, Indiana, 47403, USA
Baxter Pharmaceutical Solutions LLC, USA
927 South Curry Pike, Bloomington, Indiana 47403, USA

FILLER (AKW PKWIMRIM mbụ)

1. Baxter Pharmaceutical Solutions ELC, USA 927 South Curry Pike, Bloomington, Indiana, 47403, USA Baxter Pharmaceutical Solutions LLC, USA 927 South Curry Pike, Bloomington, Indiana 47403, USA (kadi nkata)

2. Sharp Corporation, USA 7451 Keebler Way, Allentown, PA, 18106, USA Sharp Corporation, USA 7451 Keebler Way, Allentown, Pennsylvania, 18106, USA (mgbakọ mkpọsa mkpụrụ edemede)

AKWACKKWỌ (AKW (KWỌ NSỌ (CONSUMER) AKPỌ)

Enestia Belgium NV, Belgium
Kloknerstraat 1, Hamont-Ahel, B-3930,
Belgium Enestia Belgium NV, Belgium
Klocknerstraat 1, Hamont-Achel, B-3930, Belgium

Njikwa ajụjụ

AstraZeneca UK Limited, UK
Ogige ahia ahia silk Road, Mcclesfield, Cheshire, SK10 2NA, UK
AstraZeneca UK Limited, United Kingdom brSilk Road Business Park, Macclesfield, Cheshire, SK10 2NA, United Kingdom

Aha, adreesị nke nzukọ enyere ikike ma ọ bụ onye nwe ya akwụkwọ ndebanye aha nke ọgwụ ọgwụ maka iji ọgwụ na-anabata nnabata n'aka ndị ahịa:

Onyinye nke AstraZeneca UK Limited, United Kingdom,
na Moscow na AstraZeneca Pharmaceuticals LLC
125284 Moscow, abụrụ. Gba ọsọ, 3, p

Baeta: ntuziaka maka ojiji, ọnụahịa, nyocha, analogues

Ọrịa shuga mellitus bụ ọrịa na-agbanwe ndụ mmadụ nke ukwuu. N'ihi ya, ị ga-agbaso nri siri ike na mmega ahụ, mana ọ na-eme na nke a ezughi. N'ụdị ndị ahụ, enwere mkpa maka enyemaka ahụike. Baeta bụ ọgwụ emere iji dozie ọkwa glucose ọbara.

Nsonaazụ

Tụlee mmetụta ndị nwere ike ịme mgbe ị na-eji ọgwụ:

• Ọkpụkpụ afọ. Agụụ afọ ojuju, nsogbu nke stool, vomiting, bloating in afo, nnukwu gas na eriri afọ, pancreatitis.
• Metabolism. Ọ bụrụ na ị jiri ọgwụ dịka akụkụ nke ọgwụgwọ njikọ yana insulin ma ọ bụ metformin, mgbe ahụ hypoglycemia nwere ike ime.
• Sistemụ akwara Central. Shame mkpịsị aka mkpịsị aka, mmetụta nke adịghị ike na ụba ụra.
• Allergic rashes na ntụtụ. Gụnyere ihe ọkụ ọkụ na ọzịza.
• Odida ntaramahụhụ.

Ọ bụrụ na ị theụrụ ọgwụ ahụ ogologo oge, mgbe ahụ ọdịdị nke mgbochi na ọ ga-ekwe omume. Nke a na-eme ka usoro ọgwụgwọ ọzọ ghara ịba uru. Ọ dị mkpa ịhapụ ọgwụ ahụ, jiri ọgwụ ọzọ dochie ya, ọgwụ nje ahụ ga-apụkwa.

Baeta enweghị ọgwụ mgbochi. Ọgwụgwọ maka mmetụta ndị n’akụkụ na-adabere na njiri mara.

Ọnụahịa ahụ dabere na usoro onunu ogwu:

• Maka usoro nke 1.2 ml ga-akwụ 3990 rubles.
• Maka uzo nke 2.4 ml - 7890 rubles.

N'ime ụlọ ahịa ọgwụ dị iche iche, ọnụahịa ahụ na-agbanwe. Ya mere, dịka ọmụmaatụ, achọtara ihe ngwọta nke 1.2 ml maka 5590 rubles, yana 2.4 ml - 8570 rubles.

Tụlee ihe kwekọrọ na Bayeta:

• Avandamet. O nwere ihe mejuputara metformin na rosiglitazone, nke na emeko ibe ha. Ọgwụ na - enyere aka ịchịkwa ọkwa nke glucose na sistem, na - eme ka mkpụrụ ndụ beta nke ọgwụ pancreatic dị na insulin. Enwere ike ịzụta maka 2400 rubles.
• Arfazetin. Ọ nwere mmetụta hypoglycemic. Na-enyere aka belata glucose na sistem. Enwere ike iji ya maka ọgwụgwọ na-akwado ya, mana ọ dịghị mma maka ọgwụgwọ kwesịrị ekwesị. Ọgwụ anaghị enwe mmetụta ọ bụla ma na-akarịkwa ihe analogues ndị ọzọ na-eri. Ọnụahịa - 81 rubles.
• Bagomet. Nwere ihe ndị na-arụ ọrụ glibenclamide na metformin. Ọ na - eme ka insulin mara ihe. Na-ebelata cholesterol. Ọgwụ na-enyekwa aka inweta mmiri ọgwụ insulin. Enwere ike ịzụta maka 332 rubles.
• Ndị Betani N'ime usoro a si eji ndị ọrụ a, ịchọrọ ilegide ọnọdụ ọbara mgbe niile. Ọgwụ a na contraindicated na ime na lactation. Anabataghị ị toụ mmanya na ọgwụ nwere ethanol n’oge ọgwụgwọ. O siri ike ịchọta n'ụlọ ahịa ọgwụ.
• Victoza. Ọgwụ dị oke ọnụ ma dị irè. Nwere Liraglutide ihe dị n'ọrụ. Victose na-abawanye izochi insulin, mana ọ bụghị glucagon. Liraglutide na-ebelata agụụ onye ọrịa. Erere ya n'ụdị sirinji. Ọnụahịa - 9500 rub.
• Glibenclamide. Nwere ihe dị n’ime glibenclamide. Na-eme ka mmetụta insulin dị na mmiri ọ sugarụ throughụ si n’ọkpụkpụ akwara pụta. Ogwu a nwere obere nsogbu nke ịmalite hypoglycemia. Enwere ike iji ya dịka akụkụ nke ọgwụgwọ njikọta. Na-ere maka 103 rubles.
• Glibomet. Nwere metformin. Na-akwalite izoputa insulin. Enwere ike iji insulin. Ọgwụ na-abawanye njikọ nke insulin na ndị na-anabata ya, enweghị ihe ọ bụla nke ịmalite hypoglycemia. Ọnụahịa - 352 rub.
• Gliclazide. Ihe na-arụ ọrụ bụ gliclazide. Na-enye gị ohere ịmeghari ọkwa shuga na sistem. Na-ebelata ohere nke thrombosis vaskụla, nke dị mma maka ahụike onye ọrịa. Ọnụahịa - 150 rubles.
• Metformin. Na-egbochi gluconeogenesis. Ọgwụ anaghị enye aka na nzuzo nke insulin, mana ọ na-agbanwe oke ya. Na-eme ka mkpụrụ ndụ akwara nwee ike ịmịkọrọ glucose nke ọma. Ọnụahịa - 231 rub.
• Januvius. Nwere sitagliptin. Ejiri maka monotherapy ma ọ bụ ọgwụgwọ njikọta. Na-eme ka insulin na-abawanye, yana -echebe mkpụrụ ndụ ihe dị n’ime ya. Ọnụahịa - 1594 rub.

Kedu ụzọ kachasị mma iji tinye site na analogues ndị a niile? Ọ dabere na nyocha nke onye ọrịa. Anaghị anabata ya ka ọ gbanwee site na otu ọgwụ gaa na nke ọzọ n'onwe gị, tupu iji ya, ọ dị mkpa ịkpọtụrụ ọkachamara.

Tụlee nyocha ndị mmadụ na-ahapụ gbasara ọgwụ Bayeta:

Galina dere (https://med-otzyv.ru/lekarstva/144-b/35082-baeta#scomments) na ọgwụ ahụ adaghị ya mma ma ọlị: jumps shuga na injections enweghị ahụ iru ala. Nwanyị ahụ gbanwere ọgwụ ahụ naanị, ọnọdụ ya laghachiri na nkịtị. Ọ na-ede na isi ihe bụ ịnọgide na-eri nri.

Dmitry na-ekwu (https://med-otzyv.ru/lekarstva/144-b/35082-baeta#scomments) na ọ nọwo na-a theụ ọgwụ ahụ ruo otu afọ. A na-echekwa shuga n'ọkwa dị mma, mana ihe bụ isi, dị ka nwoke ahụ si dị, bụ mbelata ibu n’ahụ site na kilogram 28. Nke nsonaazụ ya, ọ na-emepụta ọgbụgbọ. Dmitry kwuru na nke a bụ ezigbo ọgwụ.

Konstantin na-ekwu (https://med-otzyv.ru/lekarstva/144-b/35082-baeta#scomments) ọgwụ ahụ dị mma, mana anabataghị injections ahụ. O nwere olile anya na ya gha enwe ike ichota analogue nke ogwu a di, na udiri mbadamba.

Nyocha na-ekwu na ọgwụ ahụ anaghị enyere mmadụ niile aka. Otu n'ime nsogbu ya kachasị bụ ụdị ntọhapụ. Nke a adighi adiri ndị ọrịa niile.

Baeta - ọgwụ na-enye gị ohere ịmeghari ogo shuga na sistem. Ọ dị oke ọnụ, mana n'ụfọdụ oge, edere ya n'efu n'ụlọ ọgwụ. Ọ bụrụ na ị attentiona ntị na nyocha ndị ọrịa, ọgwụ adịghị ebe niile.

Chekwaa ma ọ bụ kesaa: