Glibomet bụ mkpokọta ọnụ (maka ojiji maka ime ya) hypoglycemicsitere na usoro bitanide na sulfonylureasỌgbọ nke II gosipụtara extrapancreaticna ogwu nriemereme.

Ihe eji eme ya sulfonylureasỌgbọ nke abụọ - glibenclamidenwere mmetụta na-akpali akpali na insulin insulinsite na iweda mmanu na - ewe iwe na uzo iwe beta pancreas.

Glibenclamidena - eme ka enwee ike ka insulinike nke agbụ ya na mkpụrụ ndụ na-eme ka a hapụ ya insulin, na-abawanye mmetụta ya na usoro nnabata glucose umeji na akwara na adipose anụ ahụ na-egbochi ahụ lipolysis. A na-egosipụta mmetụta nke ọgwụ ahụ na ọkwa nke abụọ nke mmepụta insulin.

Ihe eji eme ya biguanide– metformingosipụtara mmetụta na-akpali akpali n'ihe gbasara ogo anụ ahụ na-emetụta ihe insulin(na-akwalite njikọta ọnụ insulinma na-abawanye nsonaazụ ya na ọkwa postreceptor).

Na eriri afọ na-ebelata nnabata glucoseịda mba gluconeogenesis ma na-emetụta n'ụzọ dị mma ọria metabolism na-enyere aka belata oke ibu na ndị ọrịa ọrịa shuga. Ọ nwere arụ ọrụ nke fibrinolytic n'ihi ihe mgbochi nke inhibitor anụ ahụ plasminogen.

Mmetụta hypoglycemic nke Glibomet na-etolite mgbe awa 2 gachara ma hụ ya ruo awa iri na abụọ.

Ngwakọta njikọta nke ọgwụ abụọ na - arụ ọrụ nke ọgwụ - ihe na - akpali akpali nke usoro mkpụrụ osisi sulfonylureasimeputa insulin nke giogwu nriime ihe) biguanidena adipose na akwara anụ ahụ (extrapancreaticime ihe - mmụba dị ukwuu na nnweta glucose) na akwara anụ ahụ (ibelata gluconeogenesis), na - enye ohere maka oke nha iji belata ọdịnaya nke mmebere ọ bụla.

Ọnọdụ a na - enyere aka izere ịmegharị ihe oke. mkpụrụ ndụ beta n’ime pancreas, ma si otua belata ihe ọghọm nke ọrụ arụ ọrụ, yana iwelie nchekwa nke ndị na - ahụ ike hypoglycemic ma belata ugboro ole enwere ike ị sideụ nsogbu ọ bụla.

Orkpachara anya glibenclamidena ngha na –eme ngwa ngwa ma n’iru di elu (84%). A na-achọpụta itinye uche kachasị mgbe awa 1-2 gachara. Nkwukọrịta na protein plasma na ọkwa nke 97%. Fọrọ nke ọma metabolized (na-adịghị eme metabolites) na imeju. A na - ekeji ya na bile na mmamiri na ogo 50/50, yana ọkara ndụ nke 5 ruo 10 awa.

Anamaghi ihe na traktọ metforminzuru oke. Ọgwụ fọrọ nke nta anaghị ejikọ ya na protein ndị dị na plasma ma gbasaa ngwa ngwa. Ahụ adịghị metabolized. Ọ na - apịpụta ya kachasị site n’akụrụ akụrụ na n’ime obere akpa n’akuku afọ, ya na ọkara ndụ nke ihe dịka awa asaa.

Ihe ngosi maka ojiji

E gosipụtara ọgwụ Glybomet maka ọgwụgwọ ụdị ọrịa shuga 2bụrụ nke enweghi ike usoro ọgwụgwọ nrina usoro ọgwụgwọ gara aga biguanidesna usoro sulfonylureasyana ọgwụ nje ọgwụ hypoglycemic ndị ọzọ.

Ihe ngbanwe

• hypersensitivity ka glibenclamide(gụnyere ihe eji eme ya sulfonylureas), metforminma ọ bụ ihe ndi ozo eji ogwu eme.
• afọ ime
• ụdị shuga 1,
• lactic acidosis(gụnyere akụkọ ihe mere eme),
• precoma ketoacidosiskopu (ọrịa mamịrị)
• ọnọdụ e jiri nri mara nri na nguzobe nke hypoglycemia,
• nnukwu ọnọdụ n'ihe ize ndụ gbasara akụrụọrịa siri ike akpịrị ịkpọ nkụ, ujo, ntinye nke ihe di iche iche nwere ayodiin (intravascular),
• ọrụ ịba ọcha n'anya,
• pathology nke akụrụ (ya na creatinine maka ụmụ nwoke karịa 135 mmol / l na maka ụmụ nwanyị karịrị 110 mmol / l),
• ọnọdụ metụtara hypoxia(akụkụ iku ume ma ọ bụ obi obaraujo bu ụzọ infarction myocardialỌnọdụ okuku iku ume)
• agba egbe, ọrịa na-efe efe, hiri nneihe ogwugwonnukwu ọbara ọgbụgba, mmerụ ahụburu ibu na-agba ọkụna ọnọdụ ndị ọzọ chọrọ ọgwụ insulin,
• 48 awa tupu mgbe ọ gachara ihe ogwugwoma ọ bụ jigide radiologicalma obu radioisotopennwale na ntinye nke ihe dị iche iche nwere ayodiin,
• leukopenia,
• mgbanwe dystrophic (lipodystrophy, myotonic dystrophy),
• porfria,
• jigide nri hypocaloric (ihe ruru 1000 kcal kwa ụbọchị),
• oseose mmenaanyammanya egbu egbu egbu,
• ụkọ glucose-6-phosphodehydrogenase,
• gbara afọ 18
• tụụrụ imena nye ara.

Emela ndụmọdụ ịkpọrọ Glybomet n'aka ndị ọrịa karịrị afọ 60 bụ ndị na-arụ ọrụ anụ ahụ dị ukwuu, n'ihi oke ihe egwu nke lactic acidosis.

• mgbasi ike nke anụ ahụ (ihe egwu nke lactic acidosis),
• ogwu gland thyroid,
• ọrịa febrile,
• hypofunctionogbugbo gren adrenalna / ma ọ bụ na lobe ihu pituitary gland.

Nsonaazụ

• Ọrịa agụụ,
• ọgbụgbọ,
• afọ mgbu
• vomiting,
• uto nke ọla n’ime oghere onu,
• afọ ọsịsa,
• mmanu nke enzymes imeju.

• hemolytic anaemia,
• leukopenia
• erythrocytopenia,
• thrombocytopenia
• megaloblastic anaemia,
• agranulocytosis,
• pancytopenia.

Ọ bụrụ na achọpụtara ngosipụta lactic acidosis(ike ọgwụgwụ, mgbu afọ, ọgbụgbọ, akwara olu), ị ga-akwụsị ozugbo were mbadamba Glibomet ma kpọtụrụ dọkịta.

• disulfiram-like mmeghachi omumegosiputara mgbe ejiri ya mmanyama mara acha ọbara ọbaraelu na akpukpo iru, isi ọwụwammetụta obi, ọgbụgbọna ọgbụgbọ mmụba n'ọbara.

Mbadamba nke glybomet, ntuziaka maka ojiji

Ntụziaka maka iji Glibomet na-atụ aro iwere mbadamba ọgwụ ahụ ọnụ (n'ime), ọkacha mma na nri.

A na-ahọpụta usoro onunu ogwu na oge ịgwọ ọrịa nke ndị dibia nọ n'ọnọdụ dabere n'ọnọdụ ahụ carbohydrate metabolism ime na ọnụ ọgụgụ ọbara glucose.

Dịka iwu, usoro izizi nke ụbọchị bụ mbadamba 1-3, na-esochi iji nwayọ nwayọ iji họrọ usoro kachasị dị mma, nke ga-ahụ nkwụsi ike ịhazi ọdịnaya glucose n’ime ọbara.

Oke kacha anabata ị ga-anabata kwa ụbọchị bụ mbadamba 6.

Dodoụbiga ya ókè

N'ihi ị overụbiga mmanya ókè, a chọpụtara ihe mmepe hypoglycemia(glibenclamide) na lactic acidosis(metformin).

Na hypoglycemia hụrụ: agụụ, adịghị ikemụbara ọsụsọnsogbu akwara ozi (nwa oge) nkuchi obi, paresthesia na onu onu pallorakpụkpọ integument ịma jijiji, isi ọwụwammetụta nchegbuogwu iro ụrammetụta nke ụjọ nsogbu ihi ụra, enweghị nhazi. Na ọganihu nke ọnọdụ a kwuru njide onwe onye na nke nsụhọ.

Bụrụ na hypoglycemiaNri dị mfe na-atụ aro shuga, ihe ọ drinksụ drinksụ ma ọ bụ ihe oriri nwere nnukwu ọnụọgụ carbohydrates(mmanụ a ,ụ, jam, tii dị ụtọ). Ọ bụrụ hypoglycemiasoro ya ọnwụ nke mmụọ, iv gbara ogwu 40% dextrose(glucose) na olu nke 40-80 ml, mgbe nke ahọpụtara infusion nke 5-10% ngwọta dextrose. Mgbe nke a gasị, nchịkwa ọzọ nke 1 mg ga-ekwe omume. glucagon.

Ọ bụrụ na onye ọrịa ahụ abanye onkonshios usoro a ka emeghachiri. Enweghi mmetụta na nke a, na-eweta nlekọta kpụ ọkụ n'ọnụ.

Na lactic acidosiskwuru: ekwuputara adịghị ikensogbu iku ume olu mgbu, iro ụra, ọgbụgbọ, mgbu afọ, vomitmgbanwe bradyarrhythmia, afọ ọsịsawedata ọbara mgbali elu, hypothermiamgbagwoju anya naọnwụ nke mmụọ.

Bụrụ na enyo enyo nke lactic acidosiskwụsị ọgwụ ahụ ozugbo, ụlọ ọgwụnwee ndidi ma mee usoro ahụ ịba ọcha n'anya.

Mmekorita

A na - eme ka mmetụta hypoglycemic nke Glybomet mee ihe mgbe ejikọtara ya na udiri coumarin (Sinkumar, Warfarin), beta-mgbochi, salicylates, Oxytetracycline, Cimetidine, Allopurinol, sulfonamides, MAO na-egbochi, Probenecid, Phenylbutazoneihe eji eme ya, chloramphenicol, Sulfonamide, cyclophosphamide, Pergexilin, Miconazole (n'ọnụ) Feniramidol, Sulfinpyrazonena ethanol.

Glucocorticoids, adrenalinemẹ ẹphe contraceptivesmgbochi ego thiazide diuretics na homonụ thyroid na-ebelata ịdị ike hypoglycemic nke Glybomet.

Na ngbanye ihe dị na iwere Glibomet, ike nke mmetụta ga-ekwe omume anticoagulants.

Ndekota nnabata Cimetidinenwere ike ịbawanye ihe ize ndụ nke lactic acidosis.

Beta igbochi nwere ike igbochi ngosipụta hypoglycemia(ewezuga bụ oke ịchafụ).

Ngwa radiopaquendị na-enwe ayodiin (maka nchịkwa intravascular) nwere ike ibute ọrụ ndị na-arụ ọrụ na arụ nchịkọta nke metformin (ihe egwu nke ịdaba lactic acidosis).

Ntụziaka pụrụ iche

N'oge usoro ọgwụgwọ, achọrọ ndị ọrịa ka ha gbasoo ndụmọdụ niile dọkịta nyere gbasara usoro ị theụ ọgwụ na usoro iji ọgwụ ahụ. mmega ahụnnabata nrina ijide onwe gị ọkwa glucosen’ime ọbara.

Lactic acidosis- ọnọdụ dị ize ndụ, mana ọ dabara nke ọma na ọrịa nje na - adịghị ahụkebe nke gosipụtara onwe ya nchịkọta nke lactic acid n'ime ọbara n'ihi mkpo metformin. Elekere lactic acidosisna ndị ọrịa na-ewere Metformina na-ahụkarị na ndị ọrịaọrịa shuga ya na ikwuru akpọ gbasara akwarana obi obara.

Iji gbochie enwere ike lactic acidosisEkwesịrị ịchọpụta ihe ndị metụtara ihe egwu ọ bụla, dịka: ketosisbutere ọrịa shuga, gbarịa agu, imeju imejuihe ojoo mmanya na-egbu egbu na ọnọdụ ọ bụla na-eduga na ya hypoxia.

Mgbe a na-enyocha usoro ọgwụgwọ Glybomet, a ga-enyocha serum creatinine mgbe niile, ọ dịkarịa ala oge 1 n'ime ọnwa iri na abụọ ọrụ akụrụ dịkarịsịrị ma ọ dịkarịa ala ugboro 2-4 na ọnwa iri na abụọ na afọ. creatininedị nso na VGN.

Ekwesịrị ilebara anya pụrụ iche n'ọnọdụ ihe egwu. arụ ọrụ ezumike (bido ọgwụgwọ) Ndị NSAID, antihypertensiveọgwụ diureticpụtara).

Glybomet ọgwụgwọ kwesịrị ịkwụsịtụ 48 awa tupu nnwale x-ray ya na invi iche bekee ayodiin nwere(n'oge oge a, ọgwụ hypoglycemic kwesịrị ị takenụ ọgwụ).

Ọzọkwa, nkwụsị ọgwụgwọ maka awa 48 chọrọ ọgwụgwọ ịwa ahụ n'okpuru ahu iziziya na epidural ma obu spinal anesthesia.

Ntinyegharia ọgwụgwọ ga - ekwe omume mgbe onye ọrịa ahụ bidoro rie nri ma ọ bụ awa iri anọ na asatọ mgbe a wachara ya arụ, dabere na akụrụ ya kwesịrị ịrụ ọrụ.

Ekwesịrị ịkpachara anya mgbe ị na-anya ụgbọala ma ọ bụ na-arụ ọrụ ziri ezi ma dị ize ndụ.

Ihe nrịba ama nke Glybomet

Ihe analogues kacha nso nke Glibomet n'ihe banyere mmetụta ha bu ndi ogwu n’egosi ha:

• Bagomet Plus,
• Ndị Gris,
• Glucofast,
• Gluconorm,
• Metglib.

Ihe eji eme ihe nke Glibomet abughi ihe ruru afo iri na asatọ.

Mmanya na-aba n'anya

Ethanol, dị ka mmanya na-egbu egbu, nwere ike ịkpasu iwe hypoglycemiayana kpatara disulfiram-like mmeghachi omume (mgbu afọ, anya ntughari, ọgbụgbọmmetụta nke okpomoku na elu ahu na ihu akpụkpọ, vomiting, tachycardia, isi ọwụwa), n'ihe metụtara nke ị ga-ahapụ ị ofụ mmanya na-aba n'anya n'ụdị niile.

Nyocha nke Glibomet

N'ime ndị ọrịa ugbu a na-a thisụ ọgwụ a, nyocha nke Glibomet na-adịkarị mma, ọ bụ ezie na ụfọdụ njikọ dị iche iche, na-adịkarị obere, mmetụta.

Ọtụtụ mmadụ na-ata ahụhụ ụdị ọrịa shuga 2were mbadamba Glibomet yana ndi ozo ndị ọrịa hypoglycemic ya mere, ha enweghị ike iji nkwenye kwenye ike nke ọgwụ a.

Ndị ọrịa ndị ọzọ edepụtara Glibomet n'oge gara aga enweghị afọ ojuju site na nsonaazụ ya ma mesịa banye na ọgwụ ndị ọzọ nke mmetụta a. Ihe ndị a niile na-egosi na ọgwụgwọọrịa shuga mellitus ịkwesịrị ịgakwuru ya n'otu n'otu, na enweghị nkwa ọ bụla na otu ọgwụ ahụ makwara mma maka ndị ọrịa niile.

Nsogbu ọzọ nke ọgwụ ejikọtara ọnụ bụ ihe edoziri edozi nke ihe ndị na - arụ ọrụ, nke na - adịtụbeghị mma maka onye ọrịa ọ bụla.

Anyị nwere ike kwubie na n'okwu ahụ mgbe Glybomet dị mma maka onye ọrịa n'ụzọ niile, ịdịmma ya ga-adịgide n'ogo dị elu, ma bụrụkwa nke mmeghachi omume na-enweghị afọ ojuju na ọgwụ nke ọgwụ ahụ, ọ ka mma ịgbanye ọgwụ ọzọ.

Ọ bara uru icheta nke ahụ ọrịa shuga Naanị dọkịta nwere ike inye gị ọgwụgwọ, dozie usoro na usoro onunu ogwu.

Leasedị mwepụta, ihe mejupụtara na nkwakọ

A na-eme Metglib n'ụdị mbadamba ihe n’akụkụ abụọ ya, na agba aja aja na-agba aja aja, yana nke ọcha.

• 500 metformin hydrochloride,
• 2,5 glibenclamide,
• 12 sodium simesum,
• 45 ọka ọka,
• 50 kaalshi hydrogen phosphate mmiri riri,
• 52 povidone
• 3 sodium stearyl fumarate,
• 35.5 microcrystalline cellulose.

Ọgwụ ahụ na-abịa n'ụdị abụọ:

• 2,5 mg glibenclamide, 500 mg metformin,
• 5 glibenclamide, 500 metformin.

A na-etinye blister na ngwugwu kaadiboodu, nke nchịkọta ya nwere ike ịbụ mbadamba 30 ma ọ bụ 40.

Ndị na-emepụta INN

Aha mba ofesi maka ogwu ahu bu Glibenclamide na Metformin.

Na-ebido ụlọ ọrụ ya Canonfarm, Russia. Adreesị: Moscow mpaghara, Shchelkovo, st. Zarechnaya, 105, ndeksi 141100.

Ọnụ ego nke ọgwụ bụ 140 rubles kwa mkpọ kwa mkpụrụ iri atọ. Na mkpokọta, ngwá ọrụ dị ọnụ, ọkachasị ma ọ bụrụ na enyere n'iwu n'ịntanetị.

Omume ọgwụ

Nke a bụ ọgwụ ngwakọta nwere metformin na glibenclamide. Ebumnuche ya bụ iwelata glucose ọbara. Ekele na ngwakọta nke ihe ndị dị n’elu a, a na-ekwupụta mmetụta a karịa.

Metformin na -ebelata oriri shuga n'ime ọbara, anaghị eme ka mwepụta nke insulin, na-eme ka mkpụrụ ndụ dịkwuo ala ma nwee glucose, na-enyere aka mee ka ọ kwụsịtụ ịnabata ya na eriri afọ ma mee ka ahụ onye ọrịa dị ike.

Glibenclamide bụ ihe dị n'ọgbọ agịga na-eme ka enwee usoro abụọ. Ọ na-ebelata shuga n'ihi eziokwu ahụ na ọ na - akpali insulin na - arụ ọrụ n'ime pancreas. N'otu oge ahụ, ijikọ mkpụrụ ndụ ọ ga-akawanye mma, a na-egbochi lipolysis na anụ ahụ adipose.

Ihe ndị a na-emekọ ibe ha n'ụzọ zuru oke, na n'ihi nke a, enwere mmụba na mmetụta hypoglycemic nke ọgwụ na ahụ. Na-agbanye ebe o si enweta ya, a na-amịkọta glucose ngwa ngwa karịa.

Mlọ ọgwụ

Mmetụta a na-ahụ anya na-apụta n'ime awa 2 mgbe ị nwusịrị Metglib, oge ọrụ nke mbadamba ahụ bụ ọkara ọkara ụbọchị.N'otu oge ahụ, mkpụrụ ndụ dị na eriri afọ na-amị glibenclamide, na-emegharị ya na imeju ka metabolites na-adịghị arụ ọrụ ma wepụta ya na akụrụ na bile, na metformin, na-etinyekwa ya na eriri afọ, na-emezi ọkachasị ndị akụrụ nwere ọdịdị mgbe niile. Oge nhazi nke glibenclamide bụ awa 4-11, metformin - 6.5.

Maka ndị na-arịa ụdị ọrịa shuga 2, ọ bụrụhaala na ọgwụgwọ enweghị ọgwụ (nri na mmega ahụ) akwụghị ụgwọ.

Ntụziaka maka ojiji (usoro)

Ọ bụ dọkịta debanye aha ya n’otu n’otu, dabere na nsonaazụ nke ule a. A na-eji ọgwụ ede ya ọgwụ. N'okwu a, a ga-agbaso ezigbo nri ka ihe ndị ahụ sie ike mee.

Ọgwụgwọ na-amalite site na 1 unit (2.5 mg na 500 mg), mgbe ahụ kwa izu na nyochaa nlele nke glucose, a na-agbanwe usoro ịha ahụ.

Ọ bụrụ na ndị ọrịa na-ejibu Metglib arụ ọrụ nke mbụ n'ụdị nkwado dị iche, ọ dị ezigbo mkpa ịtụle nke a mgbe ị na-ede ọgwụ dị mgbagwoju anya, ugbu a gụnyere ma ihe ndị na-arụ ọrụ n'otu oge.

Ikpachara anya: Onu ogugu mbadamba nke ubochi kariri 4 (2.5 mg ma obu 5 mg na 500 mg). Ceedgabiga nọmba a nwere ike iduga ngbanye.

Mkparịta ụka ọgwụ ọjọọ

Can nweghị ike ijikwa miconazole na Metglib. Nke a nwere ike ibute nkụ.

Site na ntinye nke iodine nwere ihe dị iche iche iji zere nsogbu nsogbu ọrụ na-arụ ọrụ ezumike, a na-akwụsị nnabata ụbọchị abụọ tupu usoro a ma maliteghachi naanị mgbe nyochachara ka awa 48 gachara.

Nmekorita na ethanol, phenylbutazone, bosentan adighi akwadoro. Ha na-akụghasị nsonaazụ Metglib ma nwee ike ibute mmeghachi omume ndị achọghị.

Agbanyeghị, a naghị adụ ọdụ ka ha tinye ya na usoro ọgwụgwọ bụ isi:

• beta adrenostimulants,
• chlorpromazine
• glucocorticosteroids,
• diuretics
• Ihe mgbochi ACE na MAO,
• anticoagulants
• danazol
• desmopressin na ụfọdụ ọgwụ ndị ọzọ.

Na mmekorita, ha nwere ike bute hypoglycemia ma belata ịdị n’otu.

Mwepụta wepụtara ya na ihe mejupụtara

A na-emepụta ọgwụ ahụ n'ụdị mbadamba ndị nwere ihe nkiri: okirikiri, biconvex, agba aja aja-agba na agba, ọ fọrọ nke nta ka ọ bụrụ ọcha na mpaghara obe (10 nke ọ bụla na blisters, na ngwugwu kaadi nke 1, 2, 3, 4, 6, ma ọ bụ 9 nke ngwugwu. , Kọntaktị 15. Na ngwungwu na agba, na ngwugwu kaadi nke 2, 4 ma ọ bụ 6, mkpọ nke ọ bụla nwekwara ntuziaka maka iji Metglib).

Otu mbadamba 1 nwere:

• bekee na-arụ ọrụ: metformin hydrochloride - 400 mg, glibenclamide - 2.5 mg,
• ihe ndi ozo: stachi ọka, macrogol (polyethylene glycol 6000), calcium hydrogen phosphate dihydrate, sodium stearyl fumarate, croscarmellose sodium, microcrystalline cellulose, povidone,
• n'ọbọ ihe nkiri: hyperlose mmanụ oroma (hydroxypropyl cellulose), hypromellose (hydroxypropyl methyl cellulose), titanium dioxide, talc, iron oxide odo na acha uhie uhie.

Metglib, ntuziaka maka ojiji: usoro na usoro onunu ogwu

A na-eji ọnụ ede mbadamba Metglib.

O were ọgwụ a, etu eji ya na oge ọgwụgwọ ya ka dibịa bekee na-eleba anya na steeti carbohydrate na nsogbu ịba ọchaa n'ime ọbara.

N'ọtụtụ oge, a na-ewere Metglib na mbido 1-2 kwa ụbọchị, yana isi nri. N’ọdị n’ihu, a na-eme mmezi nke iji nwayọ were rụpụta ihe kachasị arụ ọrụ, nke nwere ike inye nguzosi ike nke ọkwa glucose ọbara. N'okwu a, oke sọma a na-anabata kwa ụbọchị ekwesịghị gafere mbadamba 6, nke kewara ụzọ atọ.

Ime na lactation

A naghị atụ aro ka ụmụ nwanyị dị ime were Metglib. N'oge usoro ọgwụgwọ ahụ, a ga-eme ka dọkịta na-aga nnọchiteanya mata ime ahụ ezubere ma ọ bụ mmalite ya, ebe ọ bụ na n'ọnọdụ ndị a, ọ dị mkpa ịkwụsị ị theụ ọgwụ ma nyefee onye ọrịa ahụ insulin.

N'oge a na-enye nwa ara, a na-egbochi ọgwụ Metglib, n'ihi na enweghị ozi banyere ike ya ịpụpụ na mmiri ara ehi mmadụ. Ọ bụrụ n’ịchọrọ ị theụ ọgwụ n’oge ị na-ara ara, ịkwesịrị ịkwụsị inye ara ma ọ bụ gbanwee n’ịgwọ ọrịa insulin.

Metglib jikọtara ọgwụ maka ndị ọrịa mamịrị

Metglib bụ ọgwụ jikọtara ọnụ nke nwere mmetụta hypoglycemic, nke ezubere iji chịkwaa ụdị shuga 2. Uzo antidiabetic nke ogwu nke mbu choro site na uzo abuo nke ogwu ogwu di nma nke nwere usoro nkwado, nke na-enye ohere ichoputa metabolism nke insulin na glucagon. Ngwọta ya dịkwa mma maka ndị ọrịa mamịrị na-ejikọ ọgwụ ị withụ ọgwụ na insulin: ha na-ebelata ọnụọgụ na ọnụọgụ nke homonụ.

N’ezie, ihe eji eme ya ezighi ezi n ’ikpe nile (dịka ọgwụ hypoglycemic ọ bụla), mana Metglib zuru oke n’usoro ụkpụrụ nke ugbua na mkpa ya.

Ngwakọta ọgwụ ahụ

Akpụrụ echebara echiche nke ọma nyochara nke nyocha nke ihe abụọ na - arụ ọrụ - metformin (400-500 mg) na glibenclamide (2.5 mg) na-enye ohere ọ bụghị naanị ịghọta na nwekwuo ike ịchịkwa glycemic profaịlụ, kamakwa na-eme ka o nwee ike belata ogo nke ihe.

Mgbe ejiri nke ọgwụ ọdịnala ọ bụla na monotherapy, usoro onunu ogwu ha di iche iche. Na mgbakwunye na ihe ndị dị mkpa, enwerekwa ndị na-ese ihe n'ụdị cellulose, stachi, gelatin, glycerin, talc na mgbakwunye ndị ọzọ. Mbadamba ụrọ Metglib Force dịkwa ka usoro nke 5 mg glibenclamide na 500 mg metformin.

Enwere ike ịchọpụta ọgwụ mgbochi siri ike site na akara ndị a: mbadamba oval na shei na-echebe terracotta ma ọ bụ nke na-acha ọcha nwere eriri nkewa na-ejikọtara ya na mkpụrụ ndụ 10 - 90. A na-emechi blister na ntuziaka na igbe kaadi. Na Metglib ọnụahịa dị oke ọnụ: 240-360 rubles. maka mbukota.

Mlọ ọgwụ Fargacology Metglib

Akụkụ izizi nke usoro nke ọtụtụ ndị ọrịa shuga nwere ụdị ọrịa 2 maara nke ọma bụ metformin, naanị ọgwụ dị n'ụdị dị na ìgwè biguanide nke na-ebelata iguzogide ndị na-anabata mkpụrụ ndụ mebiri insulin. Ormmalite ịkọwapụta uche dị mkpa karịa mkpali maka imepụta ya, ebe ọ bụ na ụdị shuga 2, mkpụrụ ndụ β-na-enye oke ọrụ ya.

Na mgbakwunye na ịkwalite arụmọrụ insulin nke postreceptor, akụkụ ahụ nwekwara ọrụ ndị ọzọ:

• Na-egbochi nnabata nke glucose na mgbidi nke eriri afọ, mkpali nke ojiji site na anụ ahụ,
• Ihe mgbochi nke gluconeogenesis,
• Β-sel na-egbochi ntụpọ aloptosis na necrosis,
• Mgbochi ụdị acidosis na nnukwu ọrịa,
• Mkpali nke microcirculation nke mmiri ndu, ọrụ endothelial na metabolism metabolism,
• Mbelata ọbara njupụta, igbochi nchekasị oxidative, na-emezi ihe mmetụ ọbara.

Ọnọdụ dị mkpa maka ịdị adị nke profaịlụ egbugbere ọnụ nke ọrịa shuga nke afọ 2 bụ njikwa ahụ. Metformin na - enyere oke ibu ọgụ ọgụ. Ọrịa akparị na-eme ka ohere nke ọrịa kansa dịkwuo pasent 40%. Biagunide na egbochi ihe ojoo ndi di ndu. Ọbụna maka ndị ahụike karịrị afọ 40, WHO na-atụ aro iwere Metformin na usoro kachasị dị ala maka igbochi ịka nká na ihe omume obi.

Ngwakọta nke abụọ bụ isi, glibenclamide, bụ onye nnọchi anya ọgbọ ọhụrụ nke ọgwụ sulfonylurea.

A na-etinye ọgwụ ahụ na listi ọgwụ ndị dị mkpa yana mmetụta ma ọ bụrụ na ọ na-eme ka mpụ.

Site na mkpali, pancreas na –eme ka emeputa insulin nke ya. N'ihe banyere β-mkpụrụ ndụ maka ịbawanye n’ọrịa ụdị shuga 2, glibenclamide nọpụ iche na ọbụnakwa na-agbaso ọrụ ha site na-akpali ndị na-anabata mkpụrụ ndụ ndị chọrọ insulin.

Ọgwụ dị mgbagwoju anya bara uru na ọkwa niile nke mmepe nke ọrịa ahụ, ebe ọ na-enye mmetụta dị mma:

• Ọrịa ụjọ (pancreatic) - na –ekwupụta uche nke mkpụrụ ndụ lekwasịrị anya, na - echebe mkpụrụ ndụ cells-mkpụrụ ndụ glucose na - eme ihe ike, na - akpali njikọta insulin,
• Ngwucha a puru iche - metabolite na aru aru na aru na aru abuba, na egbochikwa glucogenesis, ma na - enye ohere iwepu glucose ike.

Otu ezigbo usoro nke usoro nke usoro ahụ si enyere gị aka ịgbanwe usoro onunu ogwu ka ọ dịkarịa ala, na-abawanye nchekwa nke ọgwụ, belata ohere nke nsonaazụ na nsogbu arụ ọrụ.

Usoro onunu ogwu na nhazi

Mgbe ị na-ahọrọ ọgwụ, dọkịta na-elekwasị anya na nsonaazụ nke ule, ogbo nke ọrịa ahụ, ọrịa metụtara, afọ nke ọrịa mamịrị na mmeghachi ahụ nke akụkụ nke ọgwụ ahụ.

Maka Metglib Force, dị ka ntuziaka maka ojiji a si dị, usoro izizi nke ụbọchị nwere ike ịbụ 2.5 / 500 mg ma ọ bụ 5/500 mg otu ugboro. Ọ bụrụ na ejiri otu n'ime ihe Metglib ma ọ bụ analogues nke usoro sulfonylurea mee ihe dị ka ọgwụ mbụ, mgbe ahụ, mgbe ị na-eji ọgwụ ndị ejiri dochie dochie dochie ọgwụ, ha na-eduzi ha.

Singtụ titration kwesịrị ịdị nwayọ: mgbe izu abụọ gachara, enwere ike itule ịgbatị ọgwụgwọ mbụ ahụ wee dozie ya ka ọ bụrụ ihe dịka 5/500 mg. N’oge nke ọkara otu ọnwa, ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ụkpụrụ ahụ na mbadamba 4 na usoro nke 5/500 mg ma ọ bụ mbadamba 6 nke nwere 2.5 / 500 mg. Maka Metglib nwere usoro ogwu nke 2,5 / 500, ọgwụ kachasị bụ 2 mg nke ọgwụ.

A na-ewepụta usoro usoro onunu ogwu ka ọ dị mma n'ime tebụl.

Maka ndị ọrịa mamịrị nwere ọrịa akụrụ nwere oke akụrụ, usoro ọgwụ Metglib Force ka a na-agbanyekarịkarị 2.5 / 500 mg. N'okwu a, a ga-enyocha ọnọdụ akụrụ ya mgbe niile, ebe ọ bụ na mkpokọta metformin n'oge mkpochasị ezughị oke ya dị obere, mana nnukwu nsogbu - lactic acidosis. Site na mgbatị anụ ahụ siri ike na erighị nri na-ezighi ezi, ihe mgbochi ndị ahụ yiri.

Mmetụta ndị achọghị, ịdoụbiga mmanya ókè

Nsonaazụ abụghị ihe kpatara ịgaghị agwọ ọrịa: mgbe anụ ahụ mechara, ọtụtụ mgbaaka na-apụ na nke ha, mmerụ ahụ si ọrịa shuga na-achịkwaghị achịkwa dị elu karịa ihe egwu dị na Metglib. Isi ihe bụ gbakọọ izu ole a ga - eme ya: ọ nwere ihe ọghọm ma ọ bụ ị plannedụbiga mmanya ókè, onye ọrịa mamịrị na-amalite agụụ anụ ọhịa wolf, ọ tụfuru ike, nwee ahụ ụjọ, aka ya ga-ama jijiji. Anụ ahụ na-egbu egbu ma dịkwa ure, ọnya obi na-adị ngwa ngwa, onye ahụ dị nso na-ada mba. Earnnata hypoglycemia nwere ike karịa maka ndị agadi ma daa mbà na ọrịa na hypocaloric oriri na-edozi nke ndị ọrịa mamịrị.

N'ihe banyere ịdoụbiga ihe ókè, a na-ahụ ihe ndị a:

• Ihe mgbu
• Migraines
• Ọrịa Dyspeptik
• Typesdị mmeghachi omume nfụkasị dị iche iche.

A na - ewepụ ọrịa erughị ala nwa oge site na usoro ọgwụgwọ, nkwụsi ike nke mgbaàmà chọrọ mgbakwunye Metglib analogues. – Diabeton, Dimaril, Gluconorm, Bagomet Plus, Glukovans, Glibenclamide na mgbakwunye na Metformin, Glucofast (na uche dọkịta).

Ọrịa mamịrị Banyere Metglieb

N’ebe a na-akpagharị mmụọ na Metglib, nyocha nke ndị ọrịa shuga na ndị dọkịta agwakọrịtara, n’ihi na ọtụtụ ndị ọrịa na-anọnye ọgwụgwọ siri ike, ọ na-esiri ha ike ịtụle ịdị irè nke otu ọgwụ. Ozi ndị ọzọ metụtara usoro ọgwụgwọ: ndị ahọpụtara maka usoro ọgwụgwọ ha nke ọma anaghị eme mkpesa maka nsonaazụ ndị ọzọ. Ma ịnwale ahụmịhe nke ọrịa mamịrị enweghị ezi uche na dịkwa njọ.

Na-achịkọta echiche niile, anyị nwere ike ikwubi na Metglib maka monotherapy nke ụdị shuga 2 bụ ezigbo ụzọ: nchekwa dị elu na arụmọrụ dị elu, ọnụahịa dị ọnụ ala, mmetụta dị mma na ịdị arọ nke onye ọrịa, igbochi ọrịa obi na oncological na-etinye ọgwụ ahụ n'usoro dị mma nke ọgwụ ịhọrọ nke mbụ.

Tụnyere ọgwụ ndị yiri ya

Metglib nwere otutu analogues nke bara uru iji mara onwe gị.

Ndị Glucovans. Ihe na-arụ ọrụ bụ metformin na glibenclamide.

Akwụ ụgwọ - 250 rubles kwa mkpọ.

Onye na - emepụta ihe - Merck Sante SAAS, France.

Pros: nsonaazụ nke ọgwụgwọ ahụ bụ otu ihe ahụ na Metglib, yabụ edepụtara ya ma ọ bụrụ na ọgwụ a adabaghị na onye ọrịa ahụ.

Cons: obere ọnụ karịa, otu contraindications na nsonaazụ ya.

Gluconorm. Ihe eji arụ ọrụ: yiri.

Ọnụahịa - nkezi nke 240 rubles kwa 30 ibe.

Onye na - emepụta ihe - MJ Biofarm, India.

--Rụ ọrụ - na-ebelata glucose ọbara.

Uru: adabara ọtụtụ ndị ọrịa, dị irè.

Cons: enwerekwa ọtụtụ contraindications, ọ na-efu karịa.

A na-eme ntụgharị ọgwụ ọ bụla na ọgwụ ọzọ dịka dọkịta kwuru. Amachibidoro ị medicationụ onwe gị ọgwụ!

E nwere echiche dịgasị iche iche banyere ọgwụ ndị a. Maka ụfọdụ, ọgwụ ahụ dabara adaba n'ezie, maka ndị ọzọ - mba, ndị ọzọ rịba ama ọnụ ọgụgụ dị ukwuu nke nsonaazụ. Mana n'ozuzu, nyocha dị mma karịa ndị na-adịghị mma.

Vera: “Na mbụ ha jiri Glibomet, mana ugbu a ọnụahịa arịgoro. Ajụrụ m dọkịta ka o dee ihe dị ọnụ ala karịa, mana ọ bụ otu. N'ihi ya, m nwetara Ntụziaka maka Metglib. Ọ na-efu oke belata, belata shuga nke ọma ka ị na-agbaso nri. Ma aghaghi m ịtụ ya na ahịa ọgwụ tupu - n'ihi ihe ụfọdụ, ọ na-esighi ike ibubata. Isi ihe bụ na enweghị mmetụta ọ bụla, ihe ndị ọzọ bụ oke okpukpu.

Dmitry: “Dọkịta ahụ nyere m iwu Metglib mgbe ha chọpụtara ụdị shuga 2. Ejiri m usọbọ a ihe dị ka otu ọnwa, ma ahụghị nsonaazụ pụrụ iche. Ekechaala shuga nke ukwuu, ya mere a gbanye ya na ọgwụ ọzọ. Ma ndị enyi m nụrụ na ọ na-enyere mmadụ aka nke ọma. ”

Denis: “M Metụrụ Metglib izu abụọ, izu nke iku ume pụtara. Agakwuuru m dọkịta, o ziri ozi ka a nyochaa ya. N’ihi nke a, anyị doziri usoro onunu ogwu na nri. Ugbu a ihe niile dị mma. Ọnwa abụọ abụwo ọnwa nkịtị, n'ihi ya enwere m obi ụtọ n'ọgwụ. ”

Na arụ ọrụ ezumike ọrụ

N'ime ndị ọrịa nwere ọrụ mgbazinye nsogbu, a na-ebelata nzipu nke metformin, dịka QC si dị, T,_1/2 ọ na - abawanye, nke a na - ebute mmụba ọkwa ọkwa nke metformin n'ọbara. A na - achịkwa ọchịchị Metglib na ndị ọrịa nwere akụrụ oke ma ọ bụ arụ ọrụ akụrụ, ọnụọgụ CC nke dị ala karịa 60 ml / min.

N'ihi eziokwu ahụ bụ na akụrụ mepụtara metformin, tupu ịmalite usoro ọgwụgwọ yana oge niile mgbe ọ na-emeso Metglib, achọrọ iji guzobe ọkwa QC na / ma ọ bụ serum creatinine n'ime ọbara. N'ime ndị ọrịa nwere ọrụ ezumike nkịtị, a na-atụ aro inyocha ụdị nyocha a ọbụlagodi 1 oge kwa afọ. N'ime ndị agadi ma ọ bụ na ndị ọrịa nwere CC, na-eru oke dị elu nke kwesịrị - ugboro 2-4 n'afọ. Ekwesịrị ilezi anya n'ihe banyere ọghọm nke ọrụ na -akpata ezighi ezi, dịka ọmụmaatụ, na ndị ọrịa agadi ma ọ bụ na mmalite nkwarụ antihypertensive, yana mgbe ị na-eji diuretics ma ọ bụ ọgwụ mgbochi mkpali (NSAIDs).

Nyocha banyere Metglieb

Na saịtị ahụike ọkachamara, ndị ọrịa na-ahapụ ma nyocha dị mma na nke ọjọọ banyere Metglib. Imirikiti n'ime ha rịba ama na site na iji usoro ọgwụgwọ zuru oke, ana-enweta nsonaazụ ọgwụgwọ dị mma. Agbanyeghị, n'ihi eziokwu ahụ bụ na ndị ọrịa nwere ọrịa mellitus na-ejikarị ọgwụ a yana ọgwụ hypoglycemic ndị ọzọ, ha enweghị ike ịtụle ebumnuche banyere ịdị irè nke Metglib. Ndị ọrịa niile na-arịa ọrịa shuga na-ejikọ ọnụ na otu ihe - n'oge ọgwụgwọ nke ọrịa a, dọkịta kwesịrị ịkọpụta dose ahụ, ọ bụ naanị dọkịta na-aga ya kwesịrị ịtọ ọnya na usoro.

A na-akpọkarị ọghọm ndị ahụ na ndepụta nke contraindications na mmeghachi omume ọjọọ. A na-akpọkarị ọnụ ahịa Metglib dị ọnụ ala.