Glucophage Long > Ọgwụ

Nkọwa dị mkpa maka ya 15.12.2014

Aha Latin: Glucophage dị ogologo
Usoro ATX: A10BA02
Arụ Ọrụ: Metformin (Metformin)
Emeputa: 1. MERC SANTE SAAS, France. 2. Merck KGaA, Germany.

Mbadamba ụbụrụ nwere ogologo ọrụ nwere 500 ma ọ bụ 750 mg nke ihe eji arụ ọrụ. metformin hydrochloride.

Ihe ndi ozo: sodium carmellose, hypromellose 2910 na 2208, MCC, magnesium stearate.

Pharmacodynamics na pharmacokinetics

Metformin bụ biguanideya na hypoglycemicmmetụtanwee ike belata ịtaglucose n'ọbara plasma. Agbanyeghị, ọ naghị akpali mmepụta nke insulinya mere anaghị akpata hypoglycemia. N'oge ọgwụgwọ, ndị na-anabata ihe na-eme ka insulin na-enwewanye mmetụta, glucose na-ejikwa mkpụrụ ndụ eme ihe. A na-ebelata glucose njikọta n'ihi mgbochi nke glycogenolysis na gluconeogenesis. Ewebata glucose na ngwara.

Akụkụ ike nke ọgwụ ahụ na-akpali imepụta nke glycogen site n'ime ihe na glycogen synthase. Na-eme ka ikike iburu ndị na-ebuga glucose membrane ọ bụla na - ebuga.

Na ọgwụgwọ metformin ndị ọrịa na-eburu ibu ahụ ma ọ bụ chọpụta mbelata nke obere. Ihe ahụ nwere mmetụta bara uru na metabolism lipid: na-ebelata ọkwa nke mkpokọta cholesterol triglycerides na LDL.

Ihe eji mara ogologo mbadamba nkume nwere ogologo oge ịnweta mmiri. Ya mere, usoro ọgwụgwọ ahụ na-adịgide ma ọ dịkarịa ala awa 7. Ntinye ọgwụ ahụ anaghị adabere na nri ma ọ dịghị akpata nchịkọta. Ekwuru na ejikọtara ya na protein ndị dị na plasma. Metabolism na - eme n’enweghi usoro nke metabolites. Ibepu ihe mejuputara nke oma na abia n’enweghi mgbanwe site n’enyemaka nke akụrụ.

Ihe ngosi maka ojiji

Edere Glucophage Long maka ụdị ọrịa shuga 2 n'ebe ndị okenye nọ n'ọbara ndị buru ibu oke ibu, ha anaghịkwa emega ahụ dika:

monotherapy
jikọtara ọgwụgwọ na ọgwụ hypoglycemic ndị ọzọ ma ọ bụ insulin.

Ihe ngbanwe

Edeghị ọgwụ ahụ maka:

ucheiji mezie metformin na ndi ozo.
ọrịa mamịrị ketoacidosis, precoma coma
Akụrụ ma ọ bụ arụ ọrụ akwara ezughi ezu.
nnukwu ụdị nke ọrịa dị iche iche,
mmerụ ahụ dị ukwuu na arụmọrụ,
ala ala alisụrụmaịxụbiga mmanya ókè
tụụrụ ime
lactic acidosis,
jiri awa 48 tupu ma ọ bụ mgbe redioisotope ma ọ bụ nyocha x-ray metụtara mmeghe nke iodine nwere ọdịiche,
ụdị nri hypocaloric,
erughị afọ 18.

Ekwesịrị ịkpachara anya mgbe ị na-ede akwụkwọ ọgwụ a n'ihe metụtara ndị ọrịa agadi, ndị mmadụ na-arụ nnukwu ọrụ anụ ahụ, ebe nke a nwere ike ibute mmepe lactic acidosisn'ịgwọ ụmụ nwanyị na-azụ nwa.

Nsonaazụ

N'oge ọgwụgwọ ọgwụ, mmepe ga-ekwe omume lactic acidosis, megaloblastic anaemia, mgbada nke vitamin B12 belatara.

Ọzọkwa, anaghị ekwe ka arụ ọrụ na-arụ ọrụ na - emetụta ihe na - emegharị n ’afọ, ngbanwe uto, eriri afọ, mgbu, afọ ọsịsa, agụụ. Dị ka ọ na-eme, mgbaàmà ndị a na-agbagha na mmalite nke ọgwụgwọ ma jiri nwayọọ nwayọọ kwụsị. Iji gbochie mmepe ha, a na-adụ ndị ọrịa ọdụ ka ha were metformin ọnụ ma ọ bụ ozugbo ha risịrị nri.

N'ọnọdụ ndị a na-adịghị ahụkebe, mmebi nke ọrụ nke imeju na bile, ngosipụta nke anụ ahụ mmeghachi omume nfụkasị ahụ.

Dodoụbiga ya ókè

N'ikuku metformin na usoro a na-erughị 85 g anaghị eme ka mmepe nke hypoglycemia. Mana enwere ike ito nke mmepe lactic acidosis.
Mgbe egosiputara ihe ngosi nke lactic acidosis, odi nkpa igbusi ị medicineụ ọgwụ, n'ụlọ ọgwụ, chọpụta oke nke lactate, na ịkọwapụta nchoputa ya. Achọpụtala ụzọ dị mma maka iwepụ lactate na metformin n'ahụ site na iji hemodialysis. A na-arụkwa ọgwụ na-ahụ maka ịgwọ ọrịa Symptomatic.

Mmekorita

Mmepe lactic acidosis O nwere ike ime ka nkwonkwo ọgwụ jikọta ya na iodine nwere ihe na-enye rediopaque. Yabụ, maka awa 48 tupu yana mgbe nyochachara redio nke jiri radiopaque iodine nwere, a na-atụ aro ka ekpochapụ Glucophage Long.

N’otu oge eji ọgwụ ọjọọ eme ihe na-adịghị mma hyperglycemic utịp - ọgwụ hormonal ma ọ bụ tetracosactideyana β2-adrenergic agonists, danazol, chlorpromazine na diureticsnwere ike imetụta ịta glucose n'ọbara. Ya mere, ọ dị mkpa ijikwa ihe ndị na-egosi ya, ọ bụrụ na ọ dị mkpa, mee nhazi nke usoro onunu ogwu.

Na mgbakwunye, na ọnụnọ nke ọdịda akwaradiureticskwalite mmepe lactic acidosis. Njikọ na sulfonylureas, acarbose, insulin, salicylates na - ebute hypoglycemia.

Ihe jikọrọ ya na amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprimna vancomycin, nke zoro ezo na tubules renal, na-abanye na asọmpi na metformin maka ụgbọ mmiri tubular, nke na-abawanye ịta ahụhụ.

Exbọchị mmebi

Isi analogues nke ọgwụ a: Bagomet, Glycon, Glyformin, Glyminfor, Langerine, Metospanin, Metadiene, Metformin, Siafor na ndị ọzọ.

Al useụ mmanya na-aba n’anya na-eme ka o siere mmadụ ike ịmalite lactic acidosis na nnukwu ịxụbiga mmanya ókè. A hụrụ mmetụta ahụ na-ewusi ike n'oge ibu ọnụ, na-agbaso nri kalori, yana ọnụnọ nke imeju. Ya mere, ị ,ụbiga mmanya ókè n'oge ọgwụgwọ kwesịrị ịlafu.

Nyocha Glucophage

Ọtụtụ mgbe, ndị ọrịa na-ahapụ nyocha banyere Glucofage Long 750 mg, ebe ọ bụ na enyere iwu ị doụ ọgwụ a n'oge ọgwụgwọ ụdị ọrịa shuga 2 na etiti etiti ya. N'okwu a, ọtụtụ ndị ọrịa na-achọpụta arụmọrụ zuru oke nke ọgwụ. Mgbe mgbe, enwere akụkọ na mgbe ndị ọrịa mamịrị nwere oke anụ ahụ buru ọgwụ a, mgbe e mesịrị, ha chọpụtara na mbelata dị ntakịrị na ndị na-egosi nnabata karịa.

Banyere Glucofage xr 500, enwere ike ịkọwa ọgwụ na usoro ọgwụgwọ a na usoro ọgwụgwọ mbụ. N’ọdị n’ihu, a na-anabata mmụba nwayọ nwayọ n’usoro ruo mgbe nhọrọ ahụ kacha arụ ọrụ.

O kwesiri iburu n’uche na obu onye okacha mara puru iche inye gi ọgwụ hypoglycemic obula. Na mgbakwunye na ọgwụgwọ ahụike, dọkịta ga-akwado mgbanwe maka nri, usoro mmega ahụ, nke kwesịrị ịbụ ihe dị mkpa na ndụ ndị mmadụ na-arịa ọrịa shuga. Naanị usoro a ga - ahụ maka ịdị mma nke ndụ na ọ gaghị enwe mmetụta zuru ezu mgbaàmà nke mmebi a.

Mwepụta wepụtara ya na ihe mejupụtara

Mbadamba ụrụ dị ogologo nwere 500, 750 ma ọ bụ 1,000 mg nke metformin hydrochloride nọ n'ọrụ.

Ngwakọta 1 mbadamba:

ihe na-arụ ọrụ: metformin hydrochloride - 500, 750 ma ọ bụ 1000 mg,
ihe inyeaka (500/750/1000 mg): sodium carmellose - 50 / 37.5 / 50 mg, microcrystalline cellulose - 102/01 mg, hypromellose 2208 - 358 / 294.24 / 392.3 mg, hypromellose 2910 - 10/0/0 mg, magnesium stearate - 3.5 / 5.3 / 7 mg.

Mmetụta ọgwụ

Mmetụta ọgwụ na metformin bụ iji belata shuga ọbara, nke nwere ike ịba ụba site na nri nri. Maka ahụ mmadụ, usoro a bụ ihe okike, na pancreas, nke a na-ahụ maka mmepụta insulin, so na ya. Ọrụ nke ihe a bụ mmebi nke glucose na sel.

Dịka ọgwụ na-egbochi ọrịa shuga na ịkpụkpụ ahụ, Glucophage Long na-arụ ọtụtụ ọrụ bara uru:

Na-eme ka metabolism dị ọcha ghara ịgwụ ike.
Ọ na - achịkwa mmeghachi omume nke mmebi nke carbohydrates na ntụgharị ha na abụba anụ ahụ.
Ọ na - edozi ogo nke glucose na cholesterol, nke dị ize ndụ nye ahụ.
Ọ na-ehiwepụta ekepụta insulin, nke na-ebelata agụụ ma na-efunahụ ihe ụtọ.

Mgbe ọkwa glucose ọbara dị ala, a na-eziga ụmụ irighiri akwara na uru ahụ. N'inweta ebe mgbaba, shuga na-anyụ anyụ, a na-eme ka abụba abụba, usoro oriri nke carbohydrates na-aga n'ihu nwayọ. N'ihi ya, agụụ na-agabigaghị ókè, mkpụrụ ndụ abụba anaghị agbakọ ma ọ bụ tinye ya n'akụkụ akụkụ ahụ niile.

Ntụziaka maka ojiji

Ntụziaka maka iji ya egosi na a na-ewere ọnụ Glucofage Long 1 oge / ụbọchị, n'oge nri abalị. Miri mbadamba nkume ndị ahụ, ana-elo mmiri, ana-a cheụ ya nke mmiri.

Ekwesịrị ịhọrọ dose nke ọgwụ ahụ n'otu n'otu maka onye ọrịa ọ bụla dabere na nsonaazụ nke ịtụle mkpokọta glucose dị n'ọbara. Ekwesịrị iji Glucophage Long kwa ụbọchị, na-enweghị nkwụsị. N'ọnọdụ ịkwụsị ọrịa, onye ọrịa ga-agwa dọkịta banyere nke a. Ọ bụrụ n ’ịwụọ ọgwụ ọzọ, e kwesịrị ị doseụ mmiri ọzọ n’oge a na-eme ya. Emela okpukpu abụọ nke Glucofage Long.

Monotherapy na ọgwụgwọ nkwonkwo yana njikọta ndị ọzọ hypoglycemic:

Maka ndị ọrịa na-adịghị anata metformin, usoro a na-atụ aro ịmalite Glucofage Long bụ 1 tab. 1 oge / ụbọchị
Kwa ụbọchị 10-15 nke ọgwụgwọ, a na-atụ aro ka a dozie dose ahụ dabere na nsonaazụ nke ịta ọkwa glucose ọbara. Mmụba na-adịghị ala ala na-enyere aka belata nsonaazụ akụkụ eriri afọ.
Usoro akwadoro Glucofage Long bụ 1500 mg (mbadamba abụọ) 1 oge / ụbọchị. Ọ bụrụ na, mgbe ị na-a doseụ ọgwụ a tụrụ aro, ọ gaghị ekwe omume ịnweta njikwa glycemic zuru oke, ọ ga-ekwe omume ịbawanye ọgwụ ahụ ruo na 2250 mg (mbadamba 3) 1 oge / ụbọchị.
Ọ bụrụ na ekwesighi iji nchịkwa glycemic zuru ezu na mbadamba 3. 750 mg 1 oge / ụbọchị, ọ ga-ekwe omume ịgbanye na nkwadebe metformin na mwepụta mbụ nke ihe na-arụ ọrụ (dịka ọmụmaatụ, Glucofage, mbadamba ndị nwere ihe nkiri) na ọnụọgụ kwa ụbọchị nke 3000 mg.
Maka ndị ọrịa na-anata ọgwụgwọ na mbadamba metformin, ọgwụ izizi nke Glucofage Long kwesịrị ịha ka ubochi nke mbadamba ụbọchị yana ịhapụ ya. Ndị ọrịa na-ewere usoro metformin n'ụdị mbadamba ụrọ na mwepụ mbụ na dose nke karịrị 2000 mg akwadoghị ka ha gbanwee gaa na Glucofage Long.
Bụrụ na ị na-eme atụmatụ mgbanwe site na onye nnọchianya hypoglycemic ọzọ: ọ dị mkpa ịkwụsị ị drugụ ọgwụ ọzọ wee malite ị takingụkọta Glucofage Long na oke egosiri n’elu.

Njikọ ya na insulin:

Iji nweta njikwa glucose ọbara dị mma, enwere ike iji metformin na insulin mee ihe maka njikọta ọgwụ. Ọgwụ mbụ nke Glucofage Long bụ 1 tab. 750 mg 1 oge / ụbọchị mgbe nri abalị, mgbe ahọpụtara insulin site na nha etu glucose dị n'ọbara.

Ntụziaka pụrụ iche

Tupu ịmalite ọgwụgwọ yana ọdịnihu, a ga-ekpebi imebi nke creatinine: na enweghị nkwarụ, ọ dịkarịa ala 1 oge kwa afọ, na ndị ọrịa meworo agadi, yana ndị ọrịa nwere mkpochasị nke creatinine na obere nkịtị, site na 2 ruo 4 ugboro n'afọ. Na mwepụ nke creatinine erughị 45 ml / min, ojiji nke Glucofage Long na-contraindicated.
A na-adụ ndị ọrịa ọdụ ka ha gaa n'ihu na nri ha na-a ofụ kwa ụbọchị nke carbohydrates kwa ụbọchị.
Ọrịa ọ bụla na-efe efe (ọnya afọ na ọrịa akụkụ iku ume) na ọgwụgwọ kwesịrị ịgwa dọkịta gị.
Ọ dị mkpa iburu n'uche ohere nke lactic acidosis na ọdịdị nke nkwarụ akwara, nke mgbu afọ, dyspepsia, ọnya siri ike na adịghị ike n'ozuzu ya na-esonyere ya.
Ekwesịrị ịkwụsị ọgwụ a awa 48 tupu arụ ọrụ ịwa ahụ. Ighaghachi usoro ọgwụgwọ ahụ ga - ekwe omume ka awa 48 gachara, ma ọ bụrụhaala na mgbe a na-ele ule ahụ, a ghọtara ọrụ akụrụ dị ka o kwesịrị.
Ejiri lactic acidosis bụ ihe mgbu nke afọ, ọgbụgbọ, iku ume nke acidotic, hypothermia na ngụgụ akwara. Usoro nyocha nke nchọpụta ọrịa - mbelata ọbara pH (5 mmol / l, ịba ụba lactate / pyruvate na ịba ụba oghere anionic Ọ bụrụ na a na-enyo enyo acidosis, Glucofage Long na-akwụsị ozugbo.
Na ọnụnọ nke ọrụ mgbapụta nwere ike ime ihe megidere ndabere nke iji ọgwụ antihypertensive, diuretics ma ọ bụ ọgwụ mgbochi na - abụghị steroidal na-arịa ndị agadi, a ga-elebara anya pụrụ iche.
A na - ahụkarị ihe dị elu hypoxia na ọdịda akụrụngwa na ndị ọrịa nwere nkụda obi. Otu a nke ndị ọrịa n'oge ọgwụgwọ chọrọ nleba anya oge niile gbasara ọrụ akụrụ yana ọnọdụ akụrụ na-arụ ọrụ.
N'ibubiga ibu ókè, ịkwesịrị ịgbaso nri hypocaloric (mana ọ bụghị ihe na-erughị 1000 kcal kwa ụbọchị). Ọzọkwa, ndị ọrịa kwesịrị ịme mmega ahụ nkịtị oge niile.
Iji chịkwaa ọrịa shuga, a ga-eme ule ụlọ nyocha oge niile.
Site na monotherapy, Glucophage Long anaghị akpata hypoglycemia, mana a na-atụ aro ịkpachara anya mgbe ejiri ya na insulin ma ọ bụ ndị ọzọ na-arịa hypoglycemic ọnụ. Ihe mgbaàmà nke hypoglycemia: ịsụsọ nke ịba ụba, adịghị ike, dizzness, isi ọwụwa, nkwarụ, ntị nke ntị ma ọ bụ ọhụụ.
N'ihi mmụba nke metformin, enwere ike nhịahụ ma ọ bụ nnukwu nsogbu - lactic acidosis, nke e ji egbu egbu dị elu na enweghị ọgwụgwọ mberede. Ukwuu n'ime oge Glucofage Long, ụdị ikpe ndị a mere na ọrịa mellitus nke ọrịa shuga megide ndabere nke nnukwu ọdịda akụrụ. Ihe ndi ozo kwesiri ekwenye ekwenye: ketosis, ọrịa shuga na-achịkwaghị achịkwa, ibu ọnụ ogologo oge, ọdịda imeju, ị alcoholụbiga mmanya oke yana ọnọdụ ọ bụla metụtara hypoxia siri ike.
Enwere ike wepu ihe ndị na - adịghị arụ ọrụ nke Glucofage Long site na eriri afọ adịghị agbanwe agbanwe, nke na - anaghị emetụta ọrụ ọgwụgwọ nke ọgwụ.

Mkparịta ụka ọgwụ ọjọọ

Ojiji nke oge ọgwụ nwere mmetụta hyperglycemic na-apụtaghị ìhè - ọgwụ hormonal ma ọ bụ tetracosactide, yana yana β2-adrenergic agonists, danazol, chlorpromazine na diuretics nwere ike imetụta mkpokọta glucose na ọbara. Ya mere, ọ dị mkpa ijikwa ihe ndị na-egosi ya, ọ bụrụ na ọ dị mkpa, mee nhazi nke usoro onunu ogwu.

Na mgbakwunye, na ọnụnọ akụrụ gbasara akwara, ọnya na-eme ka mmepe nke lactic acidosis. Nchikota ya na nkpochi sulfonylurea, acarbose, insulin, salicylates na - ebute hypoglycemia.

Mmepe nke lactic acidosis nwere ike ime ka njikọ nke ọgwụ na ayodiin nwere iodine nwere njikọ. Yabụ, maka awa 48 tupu yana mgbe nyochachara redio nke jiri radiopaque iodine nwere, a na-atụ aro ka ekpochapụ Glucophage Long.

Njikọ ọnụ na amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprim na vancomycin, nke zoro ezo na tubules renal, na-asọ mpi na metformin maka ụgbọ njem tubular, nke na-abawanye ịta ahụhụ.

Anyị nwetara ụfọdụ nyocha nke ifelata gbasara ọgwụ Glucofage ogologo:

Basil. Ana m a medicineara ọgwụ iji belata shuga. Edebere mbadamba 1 kwa 750 mg otu ugboro n'ụbọchị. Tupu ị theụ ọgwụ ahụ, shuga dị 7.9. Izu abụọ mgbe nke a gasịrị, gbadara 6.6 na afọ na-enweghị isi. Mana nyocha m abụghị naanị ihe dị mma.Na mbụ, afọ m na-egbu mgbu, afọ ọsịsa malitere. Mgbe otu izu gachara, itching bidoro. Agbanyeghị na ntuziaka ndị a gosipụtara, dọkịta ga-aga.
Marina Mgbe ha nyechara ọgwụ, ha butere ọgwụ insulin ma kwuo na nke a na-emekarị ndị buru ibu. Ezubere ya ka ọ were Glucofage Long 500. O weere ma nwetatụ nhazi ahụ. Tụbara ihe dịka 20 n'arọ. N'ezie, enwere mmetụta ndị ọ na-akpata, mana ọ bụ ụta ga-ata ụta maka ha. Mgbe ahụ, anyị ga-eri obere ntakịrị mgbe ị theụ ọgwụ, mgbe ahụ m ga-arụ ọrụ arụ ọrụ - isi m wee merụọ. Ma yabụ - mbadamba ihe dị ịtụnanya.
Irina Ekpebiri m ị drinkụ Glucofage Long 500 maka oke belata. N'iru ya, enwere otutu mgbalị: ma sistemu ike dị iche iche, yana mgbatị. Nsonaazụ ezughi oke, oke ibu weghachiri ozugbo nri nri kwụsịrị. Nsonaazụ sitere na ọgwụ ahụ tụrụ m n'anya: Etufuru m kilogram 3 kwa ọnwa. Aga m aga n'ihu ị toụ mmanya, ọ na-efu nnukwu ego.
Svetlana. Mama m nwere ọrịa shuga 2. Ọgwụ dị irè. Ọbara shuga agbadala nke ukwuu. A ka nwere ọrịa na-arịa mama m. Site na ọgwụ a, jisiri ike felata obere, nke siri ike ịka nká. Ahụ adịla ya mma ugbu a. Kedu ihe ga - adaba adaba - Glucophage Ogologo oge ọ bụla chọrọ ka a na-ewere ya naanị otu ụbọchị. Ma tupu oge ahụ, a na-eji ọgwụ ọgwụ ị hadụ ọgwụ ugboro abụọ - ọ bụghị adaba mgbe niile.

Dabere na nyocha, Glucofage Long bụ ọgwụ dị irè maka iji ogologo oge. A kọọrọ mmetụta ndị ọ na-enwekarị kwa mgbe. N'ibubiga ibu ókè, eji nwayọ nwayọ chọpụta ihe.

Ọgwụ ndị a bụ analogues nke ọgwụ: