Vazilip, ọgwụ Russia na ọnụahịa na nyocha

- hypercholesterolemia bụ isi nke ụdị IIa na IIb, gụnyere polygenic hypercholesterolemia, heterozygous hereditary hypercholesterolemia na hyperlipidemia agwakọta. A na-eji ọgwụ ahụ eme ihe dị ka monotherapy n'ọnọdụ ebe nri na ụzọ ọgwụgwọ ndị ọzọ ezughị.

- Mbelata onwu obi na oria obi na ndi oria ya na ngosiputa ogwu nke oria atherosclerotic ma obu oria oria, n’ariri cholesterol nke ukwu ma obu bulie elu ma dika uzo ozo iji dozie ihe ndi ozo di ndu na oria obi.

Mkparịta ụka ọgwụ Vasilip na ndekọ nke ndị nne

. Tformin na - eme ka akwara fibrinolytic dị n'ọbara site na - egbochi ihe ụdị plasminogen activates inhibitor. "G kwuru na cholesterol ga - agbadata. Ọ bụrụ na ọ belata, mgbe ahụ Vasilip. Enwekwara m ọtụtụ ọbara - haemoglobin-154. Enweelarịrị m ibu site na ọgwụ.

. Ọ bụrụ na i were ogige Oksilik, ọ gaghị ebelata ya, mana enwere ohere iji nwalee l-thyroxine Metformin ka enyere gị iwu ka ị na-eme ka metabolism na glucose kwụsị, okwu gị gbasara Vasilip bụ nkwenye na ọgwụ ndị a emetụtaghị n'onwe ha - nke a bụ ahụmịhe onwe gị. Vasilip enyereghị m aka - Arankụara m Roxer ọnwa 3. of aomi ụdị cokes n'ụdị ụmụ nwanyị, jannins na dianes na-emebi ụmụ gị, mana anaghị emetụta LH dị elu, n'agbanyeghị na prolactin dị gị mma, nke pụtara ọtụtụ)) ) Utrozhestan kwesịrị ị beụbiga mmanya ókè ma ọ bụghị ịkwụsị ma ọ bụrụ na ọ dị mkpa Otu, ọ bụghị abụọ. Vitamin na-adị na mmalite nke glutamic acid ugboro atọ n'ụbọchị na mbadamba ihe dị na 5 ruo 15 DC + foil + ayodiin, na site na 16 ruo 2.

2. Ihe mgbochi

Dịka ntuziaka ahụ si dị, vasilip na-contraindicated na:

• ọrịa imeju dị iche iche na-arụ ọrụ,
• ụba ọrụ nke imeju transaminases nke amaghi si,
• ojiji nke vasilip na inhibitors,
• hypersensitivity na mejupụtara ọgwụ,
• tụụrụ ime.

A na-adụ ọdụ ịkpachara anya iji ọgwụ a mee ihe:

• ọnụnọ nke akụkọ banyere ọrịa imeju,
• ya na oke mmebi nke usoro endocrine,
• na nsogbu nke metabolic
• ya na oria siri ike, dika imaatu,
• na mgbụsị ọbara akwara (nrụgide dị elu karịa nke ike),
• site na mmerụ ahụ na ọnya nke sitere n’ebe dị iche iche,
• ya na ụdị warakwụ na-enweghị nchịkwa,
• na myopathy (a na-akpọ ọrịa na-adịghị ala ala, ọrịa akwara na-aga n'ihu mgbe niile, nke metabolism dị na akwara anụ ahụ na-arụ ọrụ),
• n'oge ịwa ahụ,
• na ị abuseụbiga mmanya ókè.

3. Nsonaazụ

Vasilip nwere ike ịrụ ọrụ na-adịghị mma n'ahụ ahụ mmadụ, ihe ndị kachasị na ha bụ:

Ọrịa ọgbụgba, oke akwara akụrụngwa, ọrịa palpitations, belata ọrụ nwoke na nwanyị adịghị obere.

4. ofzọ nchịkwa nke ọgwụ

A na -ewere Vasilip n'ọnụ, na enwere ike ịtọ dose ahụ dabere na ngosipụta na ogo ọrịa site na 5 ruo 80 mg (a na-eji ọnụọgụ ọgwụ kachasị elu iji gwọọ hypercholesterolemia siri ike ma ọ bụ ọnụnọ nke nnukwu nsogbu nke nsogbu na ọrụ achikota nke usoro akwara obi.

Ọ bụ dibịa na-eleta ga-edepụtara oge ọ ga-anabata. Omuma di egwu bu 10 mg nke otu ubochi obula, na dika ihe aka ndi apuru aputa si di ike, okpukpu abuo rue uto.

Gbanwee ọgwụ nke ọgwụ a karịa oge 1 kwa ọnwa.

5. Mmekọrịta Ọgwụ

1. Ọgwụ a nwere ike ịkwalite mmetụta anticoagulants na-apụtakarị, nke nwere ike ịkpalite ọbara ọgbụgba.
2. Ọ na - eme ka ị nwekwuo Digoxin n'ọbara, yabụ, ndị ọrịa nwere ụdị ọgwụgwọ a ka ndị dọkịta nyochaa ha.

Nlekọta nke imekotaotu oge ya na cytostatics na antifungal (Ketoconazole, Itraconazole), fibrates, oke nicotinic acid, immunosuppressants, ndị na-egbochi proteinase na-eme ka ohere nke mmepe rhabdomyolysis dịkwuo oke.

6. dodoụbiga ya ókè

Enwere ikpe nke gafere oke nke Vasilip, agbanyeghị, ha butereghị nsonaazụ na nnukwu mmebi iwu. N'agbanyeghi nke a, n'ihe banyere ịdoụ ọgwụ ọ drugụdoụ gabigara ókè, ọ dị mkpa ị enụ ọgwụ mmiri ma hichaa afọ, a na-atụ aro ịbanye na ahụ ahụ, karịsịa maka akụrụ na imeju.

7. Wepụta ụdị ndụ

A na-emepụta ọgwụ ahụ site na ụlọ ọrụ ọgwụ n'ụdị mbadamba ụrọ nke agba fim.

Otu mbadamba osisi nwere ike ịbụ usoro ọgwụgwọ dị iche - 10 mg, 20 mg, 40 mg.

Na ngwugwu - 14 ma ọ bụ mkpụrụ ego 28.

Ndụ nchekwa nke Vasilip bụ afọ 3.

Amalolo na-ewu ewu maka ọgwụ Vasilip:

N'ime ụlọ ọrụ na-ere ọgwụ, a na-ere ọgwụ ahụ na ọnụahịa ndị a (dabere na dose):

• na Russia - site na 328 ruo 587 rubles,
• na Ukraine - site na 82 ruo 148 hryvnias.

Ndị ọrịa a tookụrụ ọgwụ a chọpụtara mbelata cholesterol ọbara, mmụba nke ọnọdụ izugbe, na ogologo oge nke ọgwụ ahụ.

Agbanyeghị, nke a na-egosi ngosipụta nke mmetụta ọjọọ ndị na-adịghị mma nke na-apụ n'anya mgbe njedebe nke ịnwe Wazilip. You nwere ike gụọ nkọwa zuru ezu banyere nyocha nke ndị ọrịa ji Vazilip na njedebe nke edemede.

11. Ntụziaka pụrụ iche

1. Tupu ịmalite ọgwụgwọ na Vazilip, ịkwesịrị iduzi nyocha ụlọ nyocha nke ndị na-egosi ọrụ imeju na inyochakwu ọrụ nke mmịnye imeju kwa ọnwa 1.5-2. A na-enyochakarị ndị ọrịa na-anata simvastatin kwa ụbọchị n'ọtụtụ kachasị (80 mg) maka ọrụ imeju - otu ugboro kwa ọnwa atọ. Site na mmụba nke ọrụ transaminases, a na-akagbu ọgwụgwọ Vasilip.
2. A na-akwụsị ndị ọrịa nwere myasthenia gravis, myalgia, ma ọ bụ ndị na-arụ nnukwu ọrụ nke usoro ọgwụgwọ CPK na ọgwụ a na-ajụ.
3. A naghị akwado Simvastatin ma ọ bụrụ na enwere ihe egwu nke rhabdomyolysis ma ọ bụ ọdịda akụrụngwa (n'ihi hypotension akwara, ọrịa na-efe efe, nnukwu nsogbu metabolic, mmerụ ahụ).
4. Ihe mejupụtara Vasilip na-emetụta oke nke nwa ebu n’afọ, yabụ, ekwesịrị ịhapụ ọgwụ ahụ maka ọgwụgwọ nke ụmụ nwanyị dị ime. Ọ bụrụ na ime dị ime n'oge ọgwụgwọ Vazilip, mgbe ahụ a kwụsịrị ọgwụ ahụ.
5. Ọgwụ a dị irè ma na monotherapy yana yana usoro nke bile acid.
6. Ọnọdụ dị mkpa maka ọgwụgwọ Vasilip bụ onye ọrịa nọ na nri cholesterol.
7. Ọ bụrụ na echefula na usoro nke ugbu a, ịkwesịrị ị theụ ọgwụ ọzọ dị ka oge ọ bụla ị nwere ike ịgọnahụ ya.
8. N'ihe banyere mgbu na - akọwaghị na akwara, a na-atụ aro onye ọrịa ka ọ kpọọ dọkịta ozugbo.

Emere ọgwụ ọgwụ

Ihe na-arụ ọrụ nke Vasilip nwere mmetụta dị ala ma belata cholesterol na plasma ọbara. Ọgwụ dị irè n'ọrịa obi obi, ebe ọ na-ebelata ihe ize ndụ nke infarction myocardial. Mmetụta ọgwụgwọ nke vasilip na - etolite n'ime oge izu abụọ, ihe kachasị na - apụta mgbe ọnwa were n'ọrụ kwa ụbọchị.

Na mgbakwunye, Vasilip, dịka nyocha si kwuo, nwekwara mmetụta mgbochi atherosclerotic, na-emetụta akụkụ nke ọbara na mgbidi arịa ọbara.

Kedụ ụdị emepụtara

Vasilip dị n'ụdị mbadamba ihe eji eme ihe nkiri nwere ihe dị ka 10, 20 na 40 mg nke simvastatin na-arụ ọrụ. 7 mbadamba kwa ọnya.

Ọ bụrụ na ọ dị mkpa, enwere ike dochie ọgwụ ahụ na otu n'ime analogues nke Vazilip - simplacor, avestatin, holvasim, atherostat, simvakard, actalipid, zokor, simgal, vasilip, zorstat, aries, simvor, simvagheksal, simvalimit, simvastatin, simlo, sincard ma ọ bụ zovatin.

Mgbe ị na-enweghị ike ịhọpụta

Dabere na ntuziaka ndị ahụ, Vasilip bụ contraindicated maka iji:

• Ọrịa imeju na-arụ ọrụ na-arụ ọrụ, yana na-enwewanye mmụba na ọrụ hepatic transaminases nke etiology amaghi,
• Nlekọta nke imekotaotu onwe ya na ndị na-egbochi CYP3A4 isoenzyme, gụnyere erythromycin, itraconazole, clarithromycin, ketoconazole, nje na-egbochi nje HIV, nefazodone na telithromycin,
• Hypersensitivity na mmiri nke Vasilip.

Ọzọkwa, ọgwụ ahụ, dị ka Vazilip analogues, ekwesighi iji oge afọ ime, na-erubeghị afọ 18, n'oge a na-enye nwa ara, mgbe ị na-eme atụmatụ ịtụrụ ime ma ọ bụ ọ bụrụ na enyo ya enyo.

Ejiri Vasilip kpachara anya na:

• Akụkọ banyere ọrịa imeju,
• Ọgwụ endocrine na nsogbu nke metabolic,
• Ọrịa siri ike, gụnyere sepsis,
• Ike ọbara,
• Mmerụ ahụ
• Akwụkwụ na-achịkwaghị achịkwa,
• Myopathy
• Ihe ogwugwo di omimi,
• Mmanya na-egbu egbu, karịsịa tupu ịmalite ọgwụgwọ,
• Enweghị ntụpọ
• Enwetaghị echiche elektrolyte dị egwu,
• Galactosemia ma ọ bụ glucose-galactose malabsorption syndrome,
• Nlekọta imekotaotu oge ya na cyclosporine, fenofibrate, gemfibrozin, verapamil, nicotinic acid, amiodarone, diltiazem na mmiri mkpụrụ osisi grape.

Ofzọ nke itinye vasilip

Dịka ntuziaka ahụ si dị, a na-ewere ọnụ na Vasilip ọnụ na mgbede, ọnụọgụ dabere na ọrịa ahụ nwere ike ịdị iche site na 5 mg gaa na 80 mg, nke a na-ewere naanị na hypercholesterolemia ma ọ bụ nnukwu ihe ize ndụ nke ọrịa obi. Ọ bụ dibia bekee ga-ekpebi oge ọ ga-eji eme vasilip.

Ọtụtụ mgbe, na ọgwụgwọ hypercholesterolemia, a na-ewere Vasilip 10 mg otu ugboro, dị ka ihe na-egosi, enwere ike ịbawanye usoro ọgwụgwọ ahụ ugboro abụọ ma ọ bụ anọ. Dika nyocha, Vasilip dị irè ka ị na-elele usoro hypocholesterol ọkọlọtọ n'oge usoro ọgwụgwọ.

Site na hyzycholesterolemia homozygous, a na-enye Vasilip ọgwụ 40 mg otu mgbede ma ọ bụ 80 mg nke ọgwụ ahụ, kewara n'ime usoro 3, yana usoro ọgwụgwọ hypoliplera ndị ọzọ.

N'izi ihe egwu nwere ibute ọrịa obi, a na-ewere Vasilip 20-40 mg kwa ụbọchị dịka ntuziaka si dị. Nwere ike ịgbanwe dose nke ọgwụ a karịa otu ugboro n'ọnwa.

Dika nyocha, Vasilip dị irè ma na monotherapy yana yana colestyramine, amiodarone, colestipol, gemfibrozil, cyclosporine na fibrates ndị ọzọ ma ọ bụ nicotinic acid.

Mgbe ị na-eji Vasilip, a naghị atụ aro ka ọ rie nnukwu ego (karịa 1 lita) nke mkpụrụ osisi grape.

Nsonaazụ vasilip

Dabere na nyocha, Vasilip anaghị eduga na mmepe nke nsonaazụ ndị ọzọ, nke gosipụtara dị ka:

• Ọrịa mgbu, afọ mgbu, afọ ntachi, ọgbụgbọ, flatulence, jaundice, dyspepsia, vomiting, afọ ọsịsa na ịba ọcha n'anya,
• Paresthesia, akụkụ ụbụrụ na-enweghị atụ, ọhụhụ ụzọ, ihe ọdịdọ, ọgbụgbọ, asthenia, isi ọwụwa, ehighi ura na imebi ihe mmetụta dị ụtọ,
• Rhabdomyolysis, myopathy, akwara olu na myalgia,
• Akpukpo aru, alopecia na pruritus,
• Ọrịa ogbu ogbu na nkwonkwo, lupus-like syndrome, eosinophilia, adịghị ike siri ike, angioedema, dermatomyositis, fever, ESR, urticaria, polymyalgia rheumatism, vasculitis, thrombocytopenia, arthralgia, photoensitivity, flusiling ihu na mkpụmkpụ ume,
• Nnukwu akwara gbasara akwara, ọrịa mkpọnwụ, anaemia, na mbelatalata.

Vasilip - Nyocha banyere Vasilip - Ọnụahịa Vasilip

Vasilip bụ ọgwụ ọzọ sitere na otu nke statins, ya bụ, ọgwụ nwere ike belata cholesterol n'ime ọbara mmadụ. Emebere ya na ndabere nke simvastatin - a na - enweta ihe sitere na akụrụngwa eke (eke).

Dị ka nkwadebe yiri nke ahụ, mmadụ nwere ike ịkọwa, dịka ọmụmaatụ, Atoris, nke dabere na atorvastatin - ihe na-eme ka ahụ rụọ ọrụ. Nsonaazụ vasilip na - achọpụta ihe (n'oge nchịkwa ọbara nyocha ụlọ) izu abụọ ka ebidochara ọgwụgwọ. Mmetụta ọgwụ kachasị na-ahụ mgbe ọnwa gasịrị - otu na ọkara.

Kedu otu esi emebilata mkpokọta cholesterol na abụba ndị ọzọ (triglycerides na ihe ndị ọzọ) dị mkpa iji nyochaa oge ụfọdụ site n'inye onyinye ọbara "maka biochemistry". Ihe ngosi maka nhọpụta nke Vasilip nwere ike inweta ma zụta ụdị hypercholesterolemia.

Na mgbakwunye, igbochi na ọgwụgwọ nke atherosclerosis, ọrịa obi na akwara obi, na nkwarụ anụ ahụ ndị ọzọ tinyere abụba ọbara dị elu nwere ike ịkwado ya site na iji ọgwụ a.

Vasilip dị n'ụdị mbadamba. Atụmatụ dị oke mkpa maka ịhọrọ nwayọ nwayọ, nke akọwara ọgwụ a kọwara. Site na obere Vazilip dị obere, dọkịta ahụ kwesịrị ilebara ọnọdụ metabolic nke onye ọrịa anya ma mee mgbanwe na nhọpụta (mee ka ọnụọgụ ahụ dị elu) karịa otu ugboro n'ọnwa.

N'akụkụ, onye ọrịa ahụ ga-agbaso nri pụrụ iche, ma ọ bụghị ya, ọgwụ statin ga-akwụsị nzube ya.

Dọkịta na-atụgharị Vasilip kwesịkwara iji nlezianya nyochaa imeju onye ọrịa na akụrụ, chọpụta ụdị ọgwụ ọ na-a ,ụ, ụdị ndụ ọ na-ebi ... N'ikwu ya, statins, ọ bụ ezie na ha nwere ike ịgbanwe ọnọdụ ahụ na cholesterol, ekwesịrị iji nlezianya na -eche ya. Jiri nlezianya na-enyocha mmetụta ha n'oge oge.

Vasilip na contraindicated na ọrịa nke akụrụ, imeju, mmadụ ndidi, ime na nwa, ụmụ na ndị na-eto eto. Ọ bụrụ na nwanyị na-eji ọgwụ a, ọ kwesịrị iji nlezianya chebe onwe ya pụọ ​​na afọ ime na-enweghị nhazi. Ọ bụrụ na onye ọrịa ahụ chọrọ ịtụrụ ime, o kwesịghị ịbanye Vasilip.

Nsonaazụ vasilip

Site n'iji ọgwụ ahụ mee ihe n'ụzọ ziri ezi, nyochaa oge ọbara na-arụ ọrụ na sistemụ nke akụkụ ahụ ndị bụ isi, a na-akọwapụta ngosipụta nke mgbaàmà ndị a na-achọghị ka ọ bụrụ "obere" (ya bụ, otu ikpe na puku ikpe puku iri na ọgwụ Vasilip).

Ọkpụkpụ, usoro ụjọ, akwara nwere ike imetụta. Iji maa atụ, akọwapụtara okwu gbasara nsị imeju, isi ọwụwa, olu mgbu, ihe na-egosi ihe ndị ọzọ.

Ngosipụta nke Allergic nwere ike di iche - site na rashes nwayọ rue ọrịa anagide ọgwụ ọjọọ.

Mbadamba vasilip: ngosipụta maka ojiji, nyocha ndị ọrịa

Vasilip bụ ọgwụ nke otu ndị na-emetụta Lipid.Isi ihe dị n’omume ya bụ na ebum n’ichebelata oke lipids (abụba) n’ime ọbara. Vasilip dị n'ụdị mbadamba ọcha n'ime mpempe ihe nkiri, okirikiri, dịtụ convex n'akụkụ abụọ.

Ihe kachasị dị mkpa nke ndị ọrụ a bụ simvastatin. O nwekwara ihe ndi ozo dika lactose monohydrate, starch pregelatinized, acid citric anhydrous, vitamin C, stachi ọka, magnesium stearate na celclolose microcrystalline. Mpekere mbadamba onwe ya nwere talc, propylene glycol, hypromellose na titanium dioxide.

Usoro ị ofụ ọgwụ ahụ nwere ụdị abụọ - 20 na 40 mg nke ọ bụla.

Usoro nke vasilip

Ebe ọ bụ na Vasilip bụ ọgwụ ọgwụ na-eme ka ọ dị ala, usoro ọrụ ya dabara adaba. Nke mbu, vasilip na - ebelata oke mkpoko cholesterol n'ime obara. E nwere ụdị cholesterol abụọ - “jọrọ njọ” na “nke ọma”. “Ihe jọrọ njọ” nwere obere lipoproteins dị ala, ma “ezi” bụ mkpụrụ ndụ ihe dị mma dịkarịsịrị emerụ.

Vasilip nwere mmetụta na mmalite nke cholesterol guzobere. Ọ na-emetụta ntụgharị nke HMG-CoA (hydroxymethylglutaryl coenzyme A) na mevalonic acid. Mgbanwe a na-eme n'okpuru ike nke enzyme HMG-CoAreductase.

Vasilip nwere mmetụta na-akụda mmụọ na enzyme a, n'ihi nke cholesterol enweghị akpụ. Ọgwụ na-emetụtakwa cholesterol, nke dị n’ahụ.

Ọ na-ebelata oke cholesterol na-emetụta obere lipoproteins dị ala, ma na-ebelata ịta nke triglycerides.

Ọ bụ ihe ndị a sitere n'okike nke oke nwere ọrụ maka ihiwe onyonyo atherosclerotic na lumen nke akwara. Mana ọgwụ ahụ na-abawanye ụba nke cholesterol dị mma "nke metụtara oke lipoproteins. A na-ebelata ọkwa nke apolipoprotein B, protein pụrụ iche na-ebu ibu nke na-ebugharị cholesterol n'ime ahụ niile.

Na mgbakwunye na iwetulata ọkwa nke ụfọdụ ụdị lipids, ihe bụ isi na-arụ ọrụ nke Vasilip na-emetụta mgbidi vaskụla na ọbara onwe ya.

Ọbara ndị dị ka macrophages, bụ ndị na-ebute ụzọ na izobe nkwakọba cholesterol, ọgwụ a na - egbochi ya, ọ ga - emebi ndaba.

Ọzọkwa, njikọ nke ihe ndị a na-akpọ isoprenoids, nke na-ahụ maka uto mkpụrụ ndụ nke akwara olu nke arịa ahụ, na-ebelata nke ọma, n'ihi nke mgbidi nke arịa ahụ anaghị ebu, ma oghere ya adịghị warara. Na mgbakwunye, Vasilip na-atọpụ arịa ọbara dị mma ma na-eme ka ọbara na-erugharị nke ọma.

Njirimara nke pharmacokinetics nke vasilip

Vasilip na-egbu egbu. A na-etinye ya nke ọma site na mgbidi nke obere eriri afọ.

A na-ahụta ọgwụ kachasị n'ịgwọ ọgwụ ahụ ruo otu awa abụọ mgbe ọ jisịrị nchịkwa, mana mgbe awa 12 gasịrị, ọ na-agbada ruo 10%. Enwere ike iburu ọgwụ a na nri, nke a agaghị emetụta nsonaazụ ya.

Ọzọkwa, ọ naghị agbakọ n'ime ahụ na iji ogologo oge. Ọgwụ ahụ nwere njikọ aka na protein protein, ihe fọrọ nke nta ka ọ bụrụ 100%.

A gbanwee Vasilip ka ọ bụrụ ogige na-arụ ọrụ. A na-akpọ ogige a beta hydroxy acid. A na-ewepụta mgbatị ya (mkpochapụ) site na nnukwu eriri afọ. Ọgwụ ahụ dị n'ụdị metabolites (ngwaahịa ntụgharị).

Akụkụ obere akụkụ ya ka akụrụ ahụ ga-ahụ, mana ụdị akụrụngwa na-adịghị arụ ọrụ na-ahapụ akụrụ ahụ.

Ihe ngosi na contraindications maka ojiji

Ndị dọkịta na-edekarị ọgwụ vasilip maka ọrịa dịka atherosclerosis. Ọ bụkwa ihe a na - ahụkarị maka hypercholesterolemia ma ọ bụ dyspidemia agwakọta (imebi oke nke egbugbere ọnụ ọbara dị iche) na njikọta anụ ahụ mgbe niile, oke ibu, na - agbaso nri guzobere, ma ọ bụ na enweghị mmetụta nke ọgwụ ndị ọzọ.

Ihe ozo gosiputara bu hyzycholesterolemia homozygous. Dị ka o kwesịrị ịdị, na myirịta, nri na oriri nke ọgwụ ndị ọzọ na-emegide atherosclerotic ga-agbaso.

Edere Vasilip maka igbochi ọrịa nke akwara obi na atherosclerosis ma ọ bụ ọrịa shuga dị ugbu a, ebe ọ bụ na enwere nnukwu nsogbu nke nkụchi obi, ọrịa strok na ọrịa vaskụla dị iche iche.

Nke ikpeazu bu cholesterol di elu ma obu na ekpughi ngosiputa ogwu.

Vasilip bụ contraindicated na ọnọdụ ndị dị ka:

• ọrịa imeju na nnukwu ọrịa ma ọ bụ na-arụ ọrụ,
• ogologo oge abawanye na enzymes imeju na-enweghị ezigbo ihe kpatara ya,
• ime na lactation,
• obere afọ
• Mmeghachi ahụ nfụkasị na simvastatin ma ọ bụ ihe ọ bụla ọzọ nke ọgwụ ahụ.

Ekwesịrị ị paida ntị na ndị ọrịa ahụ nwere ọrịa ndị na-esonụ ma ọ bụ ụfọdụ ọnọdụ akọwapụtara:

1. Drinkingụbiga mmanya ókè.
2. Ọnụnọ nke ọrịa na-emetụta imeju.
3. Ọnụnọ nke echiche ezighi ezi na ahụ.
4. Nnukwu mmebi nke usoro endocrine na metabolism.
5. Ndulata mgbe niile (hypotension).
6. Ahụhụ anụ arụ.
7. Ọrịa nke usoro akwara.
8. Akwụkwụ na-adọghị ya.
9. Nnukwu ịwa ahụ ma ọ bụ mmerụ ahụ.
10. Enweghi lactase, enzyme nke na etiwapu lactose (mmiri ara ehi).
11. Mmebi nke usoro nke oriri nke lactose.

Ntuziaka maka iji ọgwụ ahụ

Tupu ị useụ ọgwụ ọ bụla, ị ga-agakwuru dọkịta gị banyere otu esi a drinkụ ya nke ọma, marakwa nkọwa ahụ. Usoro usoro ọgwụgwọ kwesịrị ị na -echekarị bụ otu ma ọ bụ karịa mbadamba ụbọchị otu ugboro n'oge ụra.

A na-atụ aro ị theụ ọgwụ ahụ n’abalị, n’ihi na n’abalị, a na-eme njikọ nke kọlestrọl ka ukwuu, mmetụta a na-emekwa ka ọgwụ pụta. Na-ebido na 10 mg. Ogologo kachasị anabata ga-anabata bụ 80 mg kwa ụbọchị.

Edere ya maka ndị ọrịa nwere ụdị ọrịa dị elu, yana nnukwu ihe egwu nke nsogbu site na obi na akwara ọbara. A họọrọ oke chọrọ n'ọtụtụ oge n'ime ọnwa.

A na-ahọrọ oge ọ ga-agwọ ọrịa iche maka onye ọrịa ọ bụla site na dọkịta na-aga ya.

Ekwesịrị icheta na mgbe ị na-ewere Wazilip, onye ọrịa n'otu n'otu nwere nri ọ ga-emerịrị. N'ọnọdụ ụfọdụ, a na-enyekwa ọgwụ ndị ọzọ na-ebelata lible.

Maka ndị ọrịa nwere ọrịa dịka hypercholesterolemia, ọgwụgwọ na-amalite site na ntụtụ 10 mg, mana enwere ike ịbawanye ya ruo 40 mg iji nweta nsonaazụ kachasị akpọpụta.

Maka ụdị ọrịa ọrịa a, a na-ekewa Vazilip ụzọ ugboro atọ ma ọ bụrụ na enyere ọgwụ kachasị (80 mg), ma ọ bụ na etinyere 40 mg nke ọgwụ otu ugboro kwa ụbọchị tupu ụra.

Vasilip nwere mmetụta achọrọ ya na ma otu iji ya yana njikọta yana ndị ọzọ na - esote ọgwụ anticholesterolemic. Ndị a bụ ọgwụ dịka colestyramine, colestipol.

Site na iji cyclosporine, gemfibrozil, nicotinic acid ma ọ bụ ọgwụ sitere na otu nke fibrates, ha na-amalite site na ọgwụ nke 5 mg, na oke kachasị anabata bụ 10 mg.

N'okwu a, ị ga-agafe ọgwụ a.

Ọ bụrụ na onye ọrịa ahụ na-a drugsụ ọgwụ ike megide arrhythmia na ọbara mgbali elu, dị ka Amiodarone na Verapamil, mgbe ahụ, ọgwụ Vasilip ekwesịghị ịbụ ihe karịrị 20 mg kwa ụbọchị, ebe ọ bụ na ndabeghị ndakọrịta ọfụma.

Ọ bụrụ na mmadụ na-ata ahụhụ n'ọrịa siri ike nke akụrụ, nke mmiri mkpochasị ụwa karịrị 30 ml / min., Edere Vasilip na ọgwụ erughi 10 mg kwa ụbọchị. Ekwesiri ịbawanye dose ahụ nke ọma, na nke a, a ga-enyocha onye ọrịa ahụ mgbe niile.

Mwepụta wepụtara ya na ihe mejupụtara

A na-emepụta Vasilip n'ụdị mbadamba ọcha (7 PC. Na blister), nke etinyere na akpụkpọ ahụ ihe nkiri.

Ntụziaka maka iji Vasilip (usoro na usoro onunu ogwu)

Mbadamba mbadamba nkume a bu n'uche maka onodu onu, otu mgbe n'uhuruchi.

Usoro a tụrụ aro dịgasị na 5 mg ruo 80 mg otu ugboro kwa ụbọchị na mgbede. Usoro mbụ nke ọgwụ ahụ bụ 10 mg. Ekwesịrị ime mgbanwe mgbanwe nke oge ụfọdụ ma ọ dịkarịa ala izu anọ.

Ogo ị na-anabata kwa ụbọchị ruru 80 mg. Edere ya naanị ndị ọrịa nwere nnukwu ihe ọrịa ma ọ bụ ọrịa hypercholesterolemia.

Ogologo oge ịre mbadamba nkume ndị ahụ, ọ bụ ndị dibia bekee kpebiri.

Hypercholesterolemia

N'ime oge ọgwụgwọ niile, onye ọrịa ahụ ga-agbaso usoro hypocholesterol ọkọlọtọ. Usoro akwadoro ịmalite maka ndị ọrịa nwere hypercholesterolemia bụ 10 mg. Iji nweta mbelata nke akpọkwu ya na LDL-C, enwere ike ịmalite ọgwụgwọ ahụ site na 20 ruo 40 mg kwa ụbọchị (otu mgbede).

N'ime ndị ọrịa nwere hypercholesterolemia homozygous, ọgwụ kwa ụbọchị bụ 40 mg na mgbede ma ọ bụ 80 mg na usoro 3 kewara (20 mg n'ụtụtụ, 20 mg n'ehihie na 40 mg na mgbede).

Mgbochi Ọrịa Obi

N'ime ndị ọrịa nwere ọrịa hyperlipidemia ma ọ bụ na-enweghị ya, nwere nnukwu nsogbu nke ọrịa obi, akwara ị doụ ọgwụ ọfụma bụ 20 ruo 40 mg kwa ụbọchị. Yabụ, usoro a tụrụ aro ka ebido rute 20 mg kwa ụbọchị.

Ekwesịrị ime mgbanwe mgbanwe oge na oge izu anọ. Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye dose ahụ ruo 40 mg kwa ụbọchị.

Ọ bụrụ na ọdịnaya LDL erughị 75 mg / dl (1.94 mmol / L), ngụkọta cholesterol dị ala karịa 140 mg / dl (3.6 mmol / L), ekwesịrị belata dose ahụ.

Usoro ọgwụgwọ na-ekwekọrịta

Vasilip dị irè na njikọta bile acid ma ọ bụ na monotherapy. N'ime ndị ọrịa na-anata ọgwụgwọ gemfibrozil, cyclosporine, nicotinic acid ma ọ bụ fibrates ndị ọzọ (karịa 1 g kwa ụbọchị), ọgwụ mbụ bụ 5 mg. Oke kachasị anabata ọgwụ kwa ụbọchị bụ 10 mg. Agaghị atụ aro ka ọ na-abawanye.

N'ime ndị ọrịa n'otu oge na-a veụ ọgwụ verapamil ma ọ bụ amiodarone, ị theụ ọgwụ kwa ụbọchị ekwesịghị ịbụ ihe karịrị 20 mg.

Mlọ ọgwụ

Simvastatin - ihe na-arụ ọrụ nke Vasilip, bụ ihe na-eme ka mkpụrụ ndụ belata nke ọma nwetara site na ngwaahịa gbaa ụka Aspergillus terreus.

Mgbe nchịkwa ọnụ gasịrị, simvastatin, nke bụ lactone na-adịghị arụ ọrụ, na-ata mmiri hydrolysis n'ime imeju, yana usoro nke β-hydroxy acid nke ihe ahụ kwekọrọ. Ọ bụ metabolite bụ isi ma nwee nnukwu ọrụ mgbochi na-egbochi HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) -reductase, enzyme nke na-ejikọ njikọ nke ndu (mbido na nke kachasị mkpa) nke cholesterol.

Nrụpụta ọrụ nke simvastatin n'ibelata plasma nke mkpokọta cholesterol, cholesterol ngụkọta, LDL cholesterol, ala nke lipoprotein cholesterol, triglycerides na oke lipoprotein cholesterol, na ịba ụba HDL cholesterol (nnukwu lipoprotein cholesterol) njupụta) na plasma ọbara n'ọbara n'ime ndị ọrịa nwere heterozygous ezinụlọ / hypercholesterolemia ma ọ bụ hyperlipidemia agwakọtara n'ihe mgbe ịba ụba ịba ụba nke plasma nke cholesterol n'ime ọbara bụ otu ihe kpatara n'ihe ize ndụ na ịhọpụta otu nri ezughị. A na-achọpụta mmetụta ọgwụgwọ na-ahụ anya n'etiti ụbọchị 14 mgbe ị na - ewere simvastatin, kachasị kachasị n'ime izu 4-6 site na mmalite iji. Site na iji usoro ọgwụgwọ na-aga n'ihu, mmetụta ahụ na-adịgide. Ngwakọta plasma nke cholesterol mgbe ọ kwụsịrị iji simvastatin n'ime ọbara na-alaghachi uru mbụ ya, nke a chọpụtara tupu ịmalite ọgwụgwọ.

Metabolite nọ n'ọrụ nke simvastatin bụ ihe na-egbochi HMG-CoA reductase (enzyme nke na-egbochi mmeghachi nke mevalonate si HMG-CoA). Agbanyeghị, nchịkwa nke usoro ọgwụgwọ nke ihe ahụ adịghị eduga n'ịrụ ọrụ nke HMG-CoA reductase, si otú a nọgide na-enwe mmepụta nke ihe dị mkpa dị mkpa nke mevalonate. Ekwenyere na iji vasilip ekwesịghị ime ka mkpokọ sterols nwere ike ịkpata ahụ, n'ihi na mmalite mmalite nke usoro ndu nke cholesterol bụ ntụgharị nke HMG-CoA ka mevalonate. Na mgbakwunye, enwere metabolism ngwa ngwa nke HMG-CoA na acetyl-CoA, nke na-etinye aka n'ọtụtụ usoro biosynthesis na ahụ.

Cholesterol bụ ihe ana - eme tupu homonụ steroid niile, a hụpụtaghị mmetụta ụlọ ọgwụ nke simvastatin na steroidogenesis. Ebe ọ bụ na Vasilip anaghị eduga na mmụba nke lithogenicity nke bile, mmetụta ya na mmụba nke cholelithiasis bụ eleghi anya.

Simvastatin na-enyere aka belata ma elu ma ọkwa nkịtị nke LDL cholesterol na plasma ọbara. Guzobe LDL sitere na VLDL (lipoproteins di nfe). A na-eme catabolism LDL tumadi site na enyemaka nke ndị na-anabata LDL dị elu na-anabata ihe. Usoro iji belata mkpokọta LDL cholesterol na plasma ọbara mgbe ị nwesịrị simvastatin nwere ike ịbụ n'ihi nbilata nke mkpụkọ plasma nke VLDL cholesterol na ọbara na mmegharị nke ndị na-anabata LDL. N'ihi nke a, enwere mbelata na ịmepụta catabolism nke cholesterol LDL. N'oge ọgwụgwọ na simvastatin, ụbara plasma nke apolipoprotein B (apo B) n'ọbara na-ebelata nke ukwuu. Ebe ọ bụ na uruu LDL nke ọ bụla nwere otu apo B nke apo, na obere apo B a na-ahụta na lipoproteins ndị ọzọ, enwere ike iche na simvastatin, na mgbakwunye na ime ka cholesterol kwụsị na LDL ụmụ irighiri ihe, na - enyere aka belata plasma nke na - ekesasị ụmụ irighiri ihe LDL n'ime ọbara.

Simvastatin na - eme ka ịbawanye elu nke HDL cholesterol ma belata ntinye nke TG na plasma ọbara. N'ihi mmekọrịta a, LDL-C / HDL-C na HDL / HDL-C belata.

Site na akwara obi (ọrịa obi na -akpata) na mkpakọ mbụ nke cholesterol nke 212-309 mg / dL (5.5 ruo 8 mmol / l), simvastatin na-enyere aka belata ihe ndị dị n'ogbugbu na-akpata ọnwụ, ọrịa sitere na obi obi na ọrịa, na nrịanrịa nke nnwale na-egosi ike myocardial infarction. Ọzọkwa, ihe ahụ na-ebelata ohere nke ịchọrọ ahụike iji weghachi ọbara ọgbụgba ọbara (dịka ọmụmaatụ, akwara ọbara na-agafekwaa ma ọ bụ na-agafe agafe. Na-emegide nzụlite nke ọrịa shuga mellitus, ihe gbasara nke puru omume nke nnukwu nsogbu akwara na-ebelata. Ọzọkwa, n'oge usoro ọgwụgwọ simvastatin, ihe ize ndụ nke ịmalite ọrịa ọrịa obi na-egbu egbu / nke na-egbu egbu (gụnyere ọrịa strok na ọrịa ụbụrụ na-adị obere oge) belatara nke ukwuu.

Enwere ihe akaebe banyere ịdị irè nke simvastatin na ndị ọrịa nwere / na-enweghị hyperlipidemia, ndị nọ n'ihe ize ndụ dị elu nke ịmalite ọrịa obi obi n'ihi ọrịa shuga mellitus, akụkọ ihe mere eme nke ọrịa strok na ọrịa vaskụla ndị ọzọ.

Site n'iji Vasilip mee ihe kwa ụbọchị nke 40 mg, onwu mkpokọta, ihe ọghọm nke ọnwụ metụtara ọrịa obi na akụrụngwa, ihe ọghọm nke nnukwu nsogbu akwara (gụnyere ọrịa myocardial infarction ma ọ bụ ọnwụ metụtara ọrịa obi), mkpa nke ịwa ahụ iji weghachi ọbara ọgbụgba na-ebelata. (tinyere akwara akwara onwa grafting na ngbapu akwara), yana obara mgbali obara na udiri mmasi ozo, onwu oria, otiti oge oghachu na se obi obara.

O nwere ike belata ndị ọrịa nwere ọrịa akwara, gụnyere ndị ọrịa na-arịa ọrịa akwara, ọrịa shuga, ma ọ bụ ọrịa ụbụrụ. Na ọrịa shuga mellitus, Vasilip na-enyere aka belata ihe ize ndụ nke nnukwu nsogbu akwara, gụnyere mkpa ịwa ahụ maka mmachi nke ala ala, mweghachi nke ọbara ọgbụgba, yana ihe ọnya trophic.

Dabere na ọrịa metụtara akwara ozi, ọgwụ simvastatin na-agbadata ọganihu nke akwara obi na atherosclerosis na ngosipụta nke saịtị abụọ nke atherosclerosis na ngụkọta mmụọ ọhụrụ, ebe ndị ọrịa na-anata usoro ọgwụgwọ gosipụtara ọganiihu nke ọnya atherosclerotic ọnya ụkwara akwara.

Mlọ ọgwụ

Simvastatin bụ lactone na-adịghị arụ ọrụ. A na-agbanye mmiri ngwa ngwa, yana ntụgharị ya na simvastatin β-hydroxy acid (L-654.969), nke bụ ihe na-egbochi ike HMG-CoA reductase. Ihe bụ isi metabolites nke simvastatin na plasma ọbara bụ β-hydroxyacid nke simvastatin (L-654.969) yana 6'-exomethylene, 6'-hydroxy na 6'-hydroxymethyl.

Ihe nchoputa maka nyocha ihe omimi banyere ihe omumu nile nke pharmacokinetic nke β-hydroxy acid metabolites (ihe na - egbochi inhibitors) na onye na - egbochi ya (latent inhibitors) (ihe mgbochi obula) nke eweputara dika hydrolysis bu ihe mgbochi nke HMG-CoA mbelata. Mgbe ị na-abanye na simvastatin na plasma ọbara, a na-ekpebi ụdị metabolites abụọ.

Hydrolysis nke simvastatin na-apụtakarị n'oge akụkụ mbụ nke imeju na-aga, ya mere, a na-ahụ ọkwa plasma dị ala nke simvastatin na-agbanweghi agbanwe na ọbara mmadụ (14 C kpọrọ simvastatin + 14 C kpọrọ simvastatin metabolites) na awa anọ. Mgbe ahụ n’ime awa iri na abụọ ọ na-agbada ngwa ngwa ruo ihe dịka 10% nke uru kachasị. N'agbanyeghi eziokwu na otutu onunu ogwu a na-atụ aro ya na simvastatin sitere na 5 ruo 80 mg kwa ụbọchị, a na-ahụta ọdịdị ahịrị nke profaịlụ AUC (mpaghara dị n'okpuru usoro ịbara) nke metabolites na-arụ ọrụ na ngụkọta ọbara na ọnụego ọnụọgụ ruo 120 mg.

Ihe dị ka 85% nke ọgwụ a na-anabata simvastatin na-abanye. Nri (dị ka akụkụ nke usoro hypocholesterol ọkọlọtọ) ozugbo ị nwesịrị simvastatin adịghị emetụta profaịlụ ọgwụ nke ọgwụ.

A na-ekpebi mkpokọta simvastatin dị elu na imeju (ma e jiri ya tụnyere ọnya ndị ọzọ).

Concentta ahụ na sistemụ sistem nke metabolite na-arụ ọrụ nke simvastatin L-654.969 bụ 60% na ụmụ nwoke).

Emebeghị ịmụ banyere ihe ahụ site na ụbụrụ ọbara na mgbochi mgbochi ọbara.

Simvastatin n'oge ụzọ mbụ dị site na imeju bụ metabolized, ihe na-esote excretion nke ihe ahụ na metabolites ya na-apụta.

Mgbe ị na-ewere 100 mg nke simvastatin 14 C, ihe akpọrọ aha na-agbakọ na plasma ọbara, yana feces (ihe dị ka 60%) na mmamịrị (ihe dị ka 13%). N’ebe a na-ahọta, a na-anọchite anya simvastatin nke akpọrọ ihe nke metabolic nke simvastatin, nke a na-egosipụta na bile, na akpọrọ simvastatin akpọghị. Ihe na-erughị 0,5% nke ịnakwere dose nke akpọrọ ihe a hụrụ n'ime mmamịrị n'ụdị nke metabolites dị mkpa nke ihe ahụ. Na plasma, 14% na 28% nke AUC bụ n'ihi ndị na - egbochi ọrụ na ndị niile na - egbochi HMG-CoA reductase, otu. Nke a na-egosi na ngwaahịa metabolism nke simvastatin na - abụkarị ọrụ anaghị arụ ọrụ ma ọ bụ ndị na - adịghị ike nke HMG-CoA reductase.

Udi ihe di nkpa nke ila akwukwo nke AUC na mkpocha obara ya na otutu onunu agha no na agha nke 5-120 mg adighi adi. Site na iji mkpụrụ osisi simvastatin otu ugboro, usoro ọgwụ pharmacokinetic gosipụtara enweghị nchịkọta nke ihe dị na akwara gbasara iji ya ugboro ugboro.

Na nsogbu akụrụngwa siri ike (na ndị ọrịa nwere ikike ịhapụ ya mkpụrụ nke 10 mg kwa ụbọchị, ọ bụrụ na ọ dị mkpa, ka ejiri nlezianya dezie ọgwụgwọ ahụ.

Vasilip, ntuziaka maka ojiji: usoro na usoro onunu ogwu

Mpempe akwụkwọ Vasilip ka a na-ewere ọnụ, 1 oge kwa ụbọchị, na mgbede. Usoro ọgwụgwọ a tụrụ aro kwa ụbọchị dịgasị site na 5 mg ruo 80 mg.

Ọtụtụ mgbe, a na-enye ọgwụ ahụ na ọgwụ mbido 10 mg. A ga-eme mgbanwe iji usoro onyonyo n'agbata oge izu anọ ma ọ dịkarịa ala. A na-atụ aro ịkarị ọgwụ kwa ụbọchị (80 mg) naanị maka ndị ọrịa nwere nnukwu hypercholesterolemia ma ọ bụ nnukwu ihe ize ndụ nke ịmalite nsogbu ọrịa obi. Ọ bụ dibia bekee na-ekpebi oge nke vasilip n'otu n'otu.

N'ime oge dum nke usoro ọgwụgwọ, onye ọrịa ahụ ga-agbaso ezigbo usoro hypocholesterol. Usoro ọgwụgwọ akwadoro ịmalite bụ 10 mg. Iji nwekwuo ike iwetulata ọkwa LDL-C (karịa karịa 45%), ị nwere ike ịmalite were Vasilip were 20-40 mg otu ugboro n'ụbọchị, na mgbede.

A na-atụ aro ka ndị ọrịa nwere ụdị hypercholesterolemia homozygous ka ha were 40 mg otu ugboro kwa ụbọchị, na mgbede. Ọ ga-ekwe omume iji usoro onunu ogwu 3 - n'ụtụtụ na n'ehihie, 20 mg na 40 mg na mgbede. A na-atụ aro Vasilip maka ndị ọrịa dị otú a na njikọta usoro ọgwụgwọ Lipid ọzọ (dịka ọmụmaatụ, LDL apheresis).

Na mgbochi nke ọrịa obi:

N'inwe ihe egwu dị elu nke ọrịa obi obi na-arịa ọrịa na-arịa (na hyperlipidemia ma ọ bụ na-enweghị ya), a na-atụpụta ọgwụ 20 V40 nke Vasilip kwa ụbọchị. Ọgwụ izizi bụ 20 mg, mmụba na dose kwesịrị ibute n'etiti oge dịkarịa ala izu anọ. Oke kachasị kwa ụbọchị bụ 40 mg. Mgbe ọdịnaya LDL erughị 75 mg / dl (1.94 mmol / L), ngụkọta cholesterol dị ala karịa 140 mg / dl (3.6 mmol / L), ekwesịrị belata usoro ahụ.

Vasilip dị irè na monotherapy ma ọ bụ n'otu oge yana usoro nke bile acid (dịka ọmụmaatụ, colestiram na colestyramine). N'ime ndị ọrịa na-anata ọgwụgwọ na gemfibrozil, cyclosporine, fibrates ndị ọzọ ma ọ bụ nicotinic acid (karịa 1 g kwa ụbọchị), a na-atụ aro ịmalite ọgwụgwọ na 5 mg kwa ụbọchị, dose kachasị kwa ụbọchị bụ 10 mg. N'ọnọdụ ndị dị otú ahụ, a naghị atụ aro maka ịba ụba na dose.

N'ime ndị ọrịa na-anata ma verapamil ma ọ bụ amiodarone, ọgwụ kwa ụbọchị nke vasilip ekwesịghị gafere 20 mg.

N'ime ndị ọrịa nwere nnukwu akụrụ oke (CC erughi 30 ml / min), ọgwụ a na-atụ aro ka Vasilip kwa ụbọchị ekwesịghị gafere 10 mg. Ọ bụrụ n’ịchọrọ ịbawanye dose ahụ, achọrọ nlekọta nlekọta ahụike.

Ndị ọrịa nwere nsogbu gbasara akụrụngwa na-eme agadi na ndị agadi achọghị mmezi dose.

Ime na lactation

Vasilip n'oge ime afọ / n'idoghị ọgwụ.

Mgbe ime dị, a ga-akwụsị iji simvastatin ozugbo. Womenmụ nwanyị toro afọ ịmụ nwa, Vasilip ka enwere ike ịkọwa ya naanị ebe enwere ike ịtụrụ ime dị obere. Ọgwụ ị duringụ ọgwụ n’oge ime nwere ike ibute mbelata nke mevalonate (ihe dị n’usoro cholesterol biosynthesis) na nwa ebu n’afọ. A na-ahụta Atherosclerosis dị ka ọrịa na-adịghị ala ala, yana ịhapụ ọgwụ ndị na-egbusi egbugbere ọnụ n'oge afọ ime emetụtaghị ihe ọghọm dị ogologo oge metụtara hypercholesterolemia. N'akụkụ a, ekwesighi inye ndị inyom dị ime simvastatin iwu, chọrọ ịtụrụ ime ma ọ bụ chee na ha dị ime. Ekwesịrị igbachi usoro ọgwụgwọ Vasilip n'oge afọ ime ma ọ bụ ruo mgbe a chọpụtara afọ ime, a ga-adọ nwanyị ahụ aka ná ntị banyere ihe ize ndụ dị na nwa ebu n'afọ.

Onweghị ihe akaebe na-egosi ma ọ bụ na-egosipụta mwepụ nke Simvastatin na metabolites ya na mmiri ara.

Ahịa maka vasilip n'ụlọ ahịa ọgwụ na Moscow

Mgwakọta dị iche iche:

• ndị na - egbochi CYP3A4 isoenzyme (itraconazole, telithromycin, ketoconazole, posaconazole, clarithromycin, voriconazole, erythromycin, nje na-egbochi nje HIV, boceprevir, nefazodone, telaprevir nwere ihe ize ndụ nke intimidia, ya
• gemfibrozil, danazol ma ọ bụ cyclosporine.

Ndi dibia nyocha banyere vasilip

Onwere oge otutu ndi dibia (obughi ogwu!) Ana ewere 10 mg nke vasilip ka obu ọgwụgwọ di nma maka oria jikọtara atherosclerosis. Oge a agafeela kemgbe. A dịghị ele Simvastatin n'ụdị ọ bụla dị ka ọgwụ na-enye gị ohere iji nweta ọkwa cholesterol ndị dị ugbu a na lipids ndị ọzọ.

Ya mere, ọ bụrụ na dọkịta ugbu a na-edepụta simvastatin (gụnyere vasilip), Amaghị m n'onwe m ihe mere o ji eleghara ihe oyiyi ọhụụ ọhụụ na-enwe mmetụta dị ike na nke dị nchebe karị.

Oge erughị echefu banyere simvastatin. Site n'ụzọ, gịnị bụ echiche a na-ekwesịghị iwere na statins karịa izu ole na ole? A na-ewere ha maka afọ na iri afọ, afọ ọ bụla ọzọ nke nnabata na-eweta abamuru ndị ọzọ na ndị ọrịa, na ụlọ ọrụ ọgwụ, dịkwa, kwa.

Nyocha nyocha Vasilip

Ana m ewere "Vasilip" 10 mg mgbe niile maka mbadamba 1 na mgbede, ana m anwale ule cholesterol otu ugboro kwa ọnwa atọ. Nsonaazụ a dị oke mma. Onwere mgbalị na-emeghi nke ọma ịgbanwere onye nlekọta ụlọ dị ọnụ ala karịa. Cholesterol wụliri elu, laghachi na "Vasilip". Site na ụgwọ ezumike nka, ịzụta dị oke ọnụ, mana ahụike dị ọnụ.

Onye ndụmọdụ nri m gwara m "Vasilip" maka ịbelata oke, mgbe m nyochachara dọkịta, m tinyere nri. N'ụzọ dị ịtụnanya, nsonaazụ ahụ dị mma, ọ bụ ezie na ejighị m n'aka kpamkpam na taabụ ga-enyere aka! Were izu 5-6, ọ gaghị ọzọ! Ọgwụ na-ebelata cholesterol n'ime ọbara, ọ bụ ya kpatara nsonaazụ dị otu a!

Ọgwụ Farmacology

Simvastatin na-emekwa ka ihe dị mma nke apolipoprotein B belata nke ukwuu, na-eme ka ịtawanye eleba anya nke HDL-C belata plasma nke TG. N'ihi nsonaazụ ndị a nke simvastatin, ọnụ ọgụgụ nke Chs na mkpokọta Chs-HDL na Chs-LDL na Chs-HDL na-ebelata.

Mmetụta antiatherosclerotic nke simvastatin bụ nsonaazụ nsonaazụ nke ọgwụ na mgbidi nke arịa ọbara na akụkụ ọbara. Simvastatin na-agbanwe metabolism nke macrophages, na-egbochi mmegharị nke macrophages na mbibi nke plahe atherosclerotic. Ọgwụ ahụ na-egbochi njikọ nke isoprenoids, nke bụ ihe na-eto eto na mmụba akwara akwara dị mma nke akwara ọbara. N'okpuru mmetụta nke simvastatin, ịgbatị arịa endothelium na-eme ka arịa ọbara dị mma.

Mmetụta ọgwụgwọ na-apụta mgbe izu abụọ gachara, a na-ahụkarị nsonaazụ kachasị mgbe izu 4-6 gachara.

Mmekorita

Ojiji simvastatin nwere fibrates, nicotinic acid (karịa 1 g / ụbọchị) na-ebulite ihe ize ndụ nke myopathy na-etolite, gụnyere rhabdomyolysis (ya na iji ya emekọ ihe na fenofibrate, ọnweghị oke nsogbu nke myopathy na-etolite na monotherapy na ọgwụ ọ bụla iche).

Ojiji a na-ejikọta ya na gemfibrozil nwere ike ibute mmụba nke simvastatin na serum.

CYP3A4 cytochrome inhibitors (itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors na nefazodone), bụ ndị na-etinye aka na ntụgharị metabolv nke simvastatin na imeju, na-abawanye n'ihe ize ndụ nke myopathy na rhabdomyolyatin n'oge ọgwụgwọ. A na-egbochi ọgwụ iji ọgwụ ndị a eme ihe.

N'iji nlezianya, ọ dị mkpa ịdebe otu oge na ndị na-egbochi CYP3A4 dị ike: cyclosporine, verapamil na diltiazem. Bọchị kwa ụbọchị nke simvastatin mgbe ị na-ewere cyclosporine ekwesịghị gafere 10 mg. Dosebọchị simvastatin kwa ụbọchị na iji ọgwụ emechi amiodarone ma ọ bụ verapamil ekwesịghị gafere 20 mg, yana 40 mg yana ojiji diltiazem, ọ gwụla ma uru a tụrụ anya ga-akacha karịa ihe ize ndụ nke myopathy na rhabdomyolysis.

Simvastatin na ntinye 20-40 mg / ụbọchị na ndị ọrụ afọ ofufo na ndị ọrịa nwere hypercholesterolemia nwere mmetụta nke anticoagulants coumarin (dịka ọmụmaatụ warfarin), ọkachasị mmụba na oge prothrombin, MHO. Ya mere, n'ime ndị ọrịa na-a anụ ọgwụ ọgwụ coumarin, a ga-ekpebi oge prothrombin na MHO tupu ịmalite usoro ọgwụgwọ simvastatin, n'oge mmalite ọgwụgwọ, mgbe ị na-agbanwe usoro nke simvastatin ma ọ bụ ịkwụsị ọgwụ ahụ. N'ịbịakwute ihe nkwụsi ike oge prothrombin na MHO, ekwesịrị ileba anya na oge ndị a tụrụ aro maka ndị ọrịa na-anata ọgwụgwọ anticoagulant. Usoro ọgwụgwọ Simvastatin anaghị akpata mgbanwe n'oge prothrombin na ihe ize ndụ ọbara ọgbụgba na ndị ọrịa ị takingụ ọgwụ anwụghị anwụ.

Ihe ọ juiceụ juiceụ mkpụrụ osisi vaịn na-egbochi ọrụ CYP3A4. N’otu oge, a ofụ nnukwu mkpụrụ osisi grape (ihe karịrị 1 lita kwa ụbọchị) na simvastatin na-ebute mmụba dị ukwuu na mkpokọta plasma nke simvastatin acid. Ya mere, n'oge ọgwụgwọ na simvastatin, mmiri mkpụrụ osisi greepu kwesịrị izere.

Ntụziaka maka iji vasilip (usoro na usoro onunu ogwu)

Maka ndị edere Vasilip, ntuziaka maka iji kọwaa na-ewere ya n'ọnụ, na mgbede, 1 oge kwa ụbọchị.

Usoro ọgwụgwọ kwa ụbọchị bụ 5-80 mg. Dịka iwu, a na-enye 10 mg ọgwụ. Ekwesịrị imeghari usoro usoro iji obere oge dị ka izu anọ. Dosebọchị kwa ụbọchị ekwesịghị ịkarị 80 mg. Ọ bụ naanị ndị nwere oke onunu ogwu ka a na-enye ya hypercholesterolemia ma ọ bụ ohere nwere ike ịdapụta nsogbu obi. Ntuziaka maka iji Vazilip na-akọ na onye ọkachamara na-ekpebi ụdị ọgwụgwọ ọ bụla n'otu n'otu, dabere na ihe ngosipụta maka ojiji na otú onye ọrịa ahụ si anabata ọgwụ ahụ.

Bụrụ na hypercholesterolemia dị mkpa iji na-eduzi nkịtị nri hypocholesterol n'oge ọgwụgwọ. Usoro ọgwụgwọ oge mbụ n'ọtụtụ oge bụ 10 mg. Maka mbelata dị egwu karị LDL cholesterol enwere ike ịmalite usoro 2040 mg / ụbọchị.

Na Hyzycholesterolemia homozygous na-ewere 40 mg ma ọ bụ 80 mg kwa ụbọchị, mana na usoro onyonye atọ (na-abụkarị 20 mg n'ụtụtụ na n'ehihie na 40 mg ọzọ na mgbede). Ọ dị mma ijikọta ọgwụ a na onye ọzọ ịbelata ikepụtara.

Iji gbochie mmepe nke ọrịa obi na ndị mmadụ nọ n'ihe ize ndụ ka ukwuu Ọrịa ụbụrụ Ischemic maa site na 20 ruo 40 mg / ụbọchị. Usoro onunu ogwu ahu, nke ahuru n’otu n’otu, belata ma oburu n’usoro LDLerughị 75 mg / dl na mkpokọta cholesterolerughị 140 mg / dl.

Enwere ike iji Vasilip mee njikọta na usoro nke bile acid. Ndị ọrịa na-anara ọgwụgwọ fibrates ma ọ bụ nicotinic acid, were usoro ọgwụgwọ nke 5 mg. Ogo kachasị nke ụbọchị ekwesịghị ịbụ ihe karịrị 10 mg. Ma mgbe ejikọtara ya na Amiodarone ma obu Verapamil agabigala onunu ogwu nke 20 mg.

Na siri ike gbasara akwara ọ ka mma ịgaghị ọgwụ 10 mg / ụbọchị. Ọ bụrụ na mmụba na usoro onunu ogwu ka dị mkpa, a ga-enyocha ọnọdụ onye ọrịa ahụ oge niile.

Mkparịta ụka ọgwụ ndị ọzọ:

• gemfibrozil na fibrates ndị ọzọ (ewezuga fenofibrate), nri fusidic: ịbawanyewanye ike nke myopathy,
• amiodarone, lomitapide, ngwa mgbochi calcium na-egbochi ngwa ngwa (verapamil, diltiazem ma ọ bụ amlodipine), nicotinic acid dị na usoro egbugbere ọnụ (dịkarịa ala 1000 mg kwa ụbọchị): ike dị elu nke ịmalite myopathy / rhabdomyolysis,
• na-egbochi nke CYP3A4 isoenzyme (dịka ọmụmaatụ, dronedarone, ranolazine): enwere ike ibelata myopathy, enwere ike belata ọgwụ Vasilip,
• OATP1B1 na - egbochi ndị na - egbochi protein: ịba ụba plasma nke simvastatin hydroxy acid na ohere nke myopathy na - eme,
• colchicine (n'ime ndị ọrịa nwere akụrụ akwara): ohere dị oke nke myopathy na rhabdomyolysis, ijikọ ọnụ na-achọ nlebara anya nke ndị ọrịa
• anticoagulants na-apụtaghị ìhè (usoro coumarin): mmụba na oge prothrombin, nke akọwapụtara dị ka MHO (njikọta ụwa nke ahaziri ahazi), a na-achịkwa uru nke ihe ngosi ahụ tupu mmalite ọgwụgwọ na simvastatin, mgbe ahụ, a na-ekpebi ya ọtụtụ oge na usoro ọgwụgwọ mbụ, nke na-enye ohere iwepu mgbanwe dị ukwuu na MHO. Mgbe o ruru ogo nke prothrombin oge, ekwesịrị ime mkpebi ya karịa oge akwadoro maka nyochaa ndị ọrịa na-anata ọgwụgwọ anticoagulant. N'ihe banyere ịgbanwe dose nke simvastatin ma ọ bụ mgbe ọ kwụsịrị, a na-atụ aro ka ịme ihe ngosi a mgbe niile. N'ime ndị ọrịa na-anaghị anticoagulants, ọgwụgwọ na simvastatin nwere ọdịdị ọbara ọgbụgba ma ọ bụ mgbanwe n'oge prothrombin adịghị ejikọta,
• ihe ọ juiceụụ mkpụrụ osisi (na nnukwu olu): ụba ọrụ plasma nke HMG-CoA reductase inhibitors.

Ihe atụ nke Vasilip bụ: Zokor, Zokor Forte, Simvor, Simvakard, Simvastol, Simlo, Simvastatin Zentiva, SimvaHEXAL, Zovatin, Levomir, Simvalimit, Actalipid, Sinkard, Aterostat, Zorstat, Simvakolat, Simvastatin, Simvastatin, Simvastatin, Simvastatin, Simvastatin, Simvastatin, Simvastatin, Simvastatin Chaikafarma, Simvastatin-SZ, Simvastatin Alkaloid, Aries, Simvastatin Pfizer.

Ime

Ya mere, ekwesighi iji umu nwanyi di ime na ndi nwanyi n’acho ime ime ma obu itu n’obi na ha di ime.
Ekwesịrị igbachi nnabata nke Simvastatin maka oge niile nke ime ma ọ bụ ruo mgbe enwere nkwenye na nwanyị ahụ adịbeghị (lee akụkụ "Contraindications").
Ihe simvastatin ji eme ụmụ nwanyị n’oge a na-ehi ụra bụ ọgwụ mgbochi.
Amabeghị ma simvastatin ma ọ bụ metabolites ya na-abanye na mmiri ara. Ebe ọ bụ na ọtụtụ ọgwụ na-abanye na mmiri ara ara ma enwere ike ibute ajọ nsogbu, ụmụ nwanyị na-a simụ simvastatin kwesịrị ịkwụsị inye ara ha. (Lee akụkụ "Contraindications").