Ntụziaka maka ị drugsụ ọgwụ, analogues, nyocha

Nọmba ndebanye: P N015030 / 04-131213
Aha ika: Augmentin®
Mba ndị na-abụghị ụlọ ahịa ma ọ bụ aha otu: amoxicillin + clavulanic acid.
Mpempe usoro onunu ogwu: ahihia maka nkwusioru nke onu ogugu.

Ngwakọta ọgwụ ahụ
Bekee arụ ọrụ:
Amoxicillin trihydrate na usoro nke amoxicillin 125.0 mg, 200.0 mg ma ọ bụ 400.0 mg na 5 ml nke nkwusioru.
Potassium clavulanate na usoro nke clavulanic acid 31.25 mg, 28.5 mg ma ọ bụ 57.0 mg na 5 ml nke nkwusioru.
Ndị e mere:
Xanthan gum, aspartame, succinic acid, silloon silicon dioxide, hypromellose, ekpomeekpo oroma 1, oroma, 2, osisi Rasberi, Molasses ekpomeekpo, silicon dioxide.
Ọha nke ihe ndị nọ n'ọrụ na nkwusioru

Sdị usoro onunu ogwu Nke ihe ndi n’aru aru oru Amoxicillin, mg (n ’usoro nke amoxicillin trihydrate) Clavulanic acid, mg (n’udi potassium clavulanate)
Ntụ ntụ maka nkwusioru 125 mg / 31.25 mg na 5 ml 4: 1 125 31.25
Ntụ ntụ maka nkwusioru 200 mg / 28.5 mg na 5 ml 7: 1,200 28.5
Ntụ ntụ maka nkwadebe nke nkwusioru nke 400 mg / 57 mg na 5 ml 7: 1 400 57

Nkọwa
Maka usoro onunu ogwu nke 125 mg / 31,25 mg na 5 ml: ntụ ntụ nke agba ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke na-acha ọcha, nwere njirimara isi. Mgbe diluted, etisasị na-acha ọcha ma ọ bụ ihe fọrọ nke nta ọcha. Mgbe ị kwụ ọtọ, ihe na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke ọma na-eji nwayọọ nwayọọ.
Maka usoro onunu ogwu nke 200 mg / 28.5 mg na 5 ml ma obu 400 mg / 57 mg na 5 ml: uzuzu nke ocha ma obu ihe ozo di ocha. Mgbe diluted, etisasị na-acha ọcha ma ọ bụ ihe fọrọ nke nta ọcha. Mgbe ị kwụ ọtọ, ihe na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke ọma na-eji nwayọọ nwayọọ.

Ndị na-ahụ maka ọgwụ: Antibiotic, penicillin penicillin + nke na-agba ọkara, + inhibitor beta-lactamase.

Koodu ATX: J01CR02

NKWUKWU PHARMACOLOGIC

Mlọ ọgwụ
Usoro nke ime ihe
Amoxicillin bụ ọgwụ mgbochi ọgwụ nke na-eme ka mmiri dị nro dị n'ọtụtụ ọgụ na -emegide ọtụtụ gram-positive na gram-microorganisms. N'otu oge ahụ, amoxicillin nwere ike ibute mbibi site na beta-lactamases, yabụ kwa ụdị ọrụ nke amoxicillin anaghị erute microorganisms nke na-emepụta enzyme a.
Clavulanic acid, ihe dị na beta-lactamase inhibitor n'ihe metụtara penicillins, nwere ike ịhapụ ịgbatị ọtụtụ beta-lactamases ndị a hụrụ na penisilini na cephalosporin na-eguzogide ọgwụ. Clavulanic acid nwere arụmọrụ zuru ezu megide beta-lactamases nke plasmid, nke na-ekpebikarị iguzogide nje bacteria, ọ dịghịkwa arụ ọrụ megide ụdị chromosomal beta-lactamases 1, nke ọgwụ clavulanic na-egbochi.
Ọnụnọ nke clavulanic acid dị na nkwadebe Augmentin® na-echebe amoxicillin site na mbibi site na enzymes - beta-lactamases, nke na-enye ohere ịgbasa ụdị antibacterial nke amoxicillin.
Ihe ndị a bụ ọrụ njikọta nke vitro nke amoxicillin na clavulanic acid.
Nje bacteria na-agbakarị ọgwụ ma ọ bụrụ na agwakọta nke amoxicillin na clavulanic acid
Gram-positive aerobes
Bacillus anthracis
Enterococcus faecalis
Listeria monocytogenes
Asteroides Nocardia
Pyogenes1 nke ikeptoptocc1
Ike kombococous 1.2
Ike kọmputa spp. (beta ọzọ hemolytic streptococci) 1,2
Staphylococcus aureus (methicillin chebara) 1
Staphylococcus saprophyticus (methicillin chebara)
Coagulase-staphylococci na-adịghị mma (na-emetụ methicillin)
Ihe anarambes dị mma
Clostridium spp.
Peptococcus niger
Peptostreptococcus magnus
Ọkpụkpọ Peptostreptococcus
Peptostreptococcus spp.
Gram-ọjọọ aerobes
Bordetella pertussis
Haemophilus influenzae1
Helicobacter pylori
Moraxella catarrhalis1
Neissevia gonorrhoeae
Pasteurella multocida
Vibrio cholerae
Gram-ọjọọ anaerobes
Bacteroides fragilis
Bacteroides spp.
Capnocytophaga spp.
Eikenella corrodens
Fusobacterium nucleatum
Fusobacterium spp.
Porphyromonas spp.
Prevotella spp.
Ndị ọzọ
Borrelia burgdorferi
Leptospira icterohaemorrhagiae
Treponema pallidum
Nje nke bu nje nke nwetara ihe ojoo na nchikota amoxicillin na clavulanic acid nwere ike idi
Gram-ọjọọ aerobes
Escherichia coli1
Klebsiella oxytoca
Klebsiella pneumoniae1
Klebsiella spp.
Proteus mirabilis
Nkwa nzuzo
Proteus spp.
Salmonella spp.
Shigella spp.
Gram-positive aerobes
Corynebacterium spp.
Enterococcus faecium
Stoniacoccus pneumoniae 1.2
Ndị Viridans na-ahụ maka Comptococcus
Nje bacteria na -eche na -echeta njikọta nke amoxicillin na clavulanic acid
Gram-ọjọọ aerobes
Acinetobacter spp.
Citrobacter freundii
Enterobacter spp.
Hafnia alvei
Legionella pneumophila
Morganella morganii
Providencia spp.
Pseudomonas spp.
Serratia spp.
Stenotrophomonas maltophilia
Yersinia enterocolitica
Ndị ọzọ
Chlamydia ka oyi baa
Chlamydia psittaci
Chlamydia spp.
Coxiella burnetii
Mycoplasma spp.
1 - maka nje ndị a, ọgwụ gosipụtara arụmọrụ nke nchịkọta nke amoxicillin na clavulanic acid na ọmụmụ ụlọ ọgwụ.
2 - ụdị dị iche iche nke nje ndị a anaghị emepụta beta-lactamases.
Ihe mmetụta uche na amoxicillin monotherapy na-atụ aro inwe uche yiri nke ahụ na nchikota nke amoxicillin na clavulanic acid.
Mlọ ọgwụ
Egwu
Ngwakọta ọrụ ike abụọ nke ọgwụ Augmentin®, amoxicillin na clavulanic acid, na-enweta ngwa ngwa ma zuo oke na eriri afọ (GIT) mgbe nchịkwa ọnụ gasịrị. Mwepu nke ihe ndi na aru oru n’ime nkwuputa Augmentin® a zuru oke ma oburu na a the nara ogwu ahu na mbido nri.
E gosipụtara usoro ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid n'ụlọ ikpe, mgbe ndị ọrụ afọ ofufo dị mma dị afọ 2 ruo afọ na afọ na-enweghị ntụ were Augmentin® ntụ ntụ maka nkwụsị ọnụ, 200 mg / 28.5 mg na 5 ml (228) , 5 mg) na nha nke 45 mg / 6.4 mg / kg kwa ụbọchị, kewara abụọ.
Mpempe ọgwụ pharmacokinetic nke bụ isi

Ihe na-arụ ọrụ Cmax (mg / l) Tmax (awa) AUC (mg × h / l) T1 / 2 (awa)
Amoxicillin 11.99 ± 3.28 1.0 (1.0-2.0) 35.2 ± 5.01.22 ± 0.28
Clavulanic acid 5.49 ± 2.71 1.0 (1.0-2.0) 13.26 ± 5.88 0.99 ± 0.14

A na-egosi usoro ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid na ule ụlọ ọgwụ n'okpuru ndị ọrụ afọ ofufo nwere ahụike were otu ọgwụ Augmentin®, ntụ ntụ maka nkwụsị ọnụ, 400 mg / 57 mg na 5 ml (457 mg).
Mpempe ọgwụ pharmacokinetic nke bụ isi

Ihe na-arụ ọrụ Cmax (mg / l) Tmax (awa) AUC (mg × h / l)
Amoxicillin 6.94 ± 1.24 1.13 (0.75-1.75) 17.29 ± 2.28
Clavulanic acid 1.10 ± 0.42 1.0 (0.5-1.25) 2.34 ± 0.94

Cmax - ịta plasma kachasị.
Tmax - oge iji rute mgbanye plasma kachasị.
AUC bụ mpaghara dị n'okpuru usoro ịta ụta.
T1 / 2 - ọkara ndụ.
Nkesa
Dika ihe ndi n’emekorita ogwu nke amoxicillin na clavulanic acid, a na acho acho ihe omimi nke amoxicillin na clavulanic acid n’ahu di iche iche na arua di iche iche (n’ime otite, akpo nke nkpuru ime, akpukpo aru, adipose na akwara akwara, synovial and peritoneal fluid, fluid, and purulent fluid). .
Amoxicillin na clavulanic acid nwere ogo na-esighi ike nke na-ejikọ protein protein. Nnyocha e mere egosiwo na ihe dị ka 25% nke ngụkọta nke clavulanic acid na 18% nke amoxicillin na plasma ọbara na-emetụta protein protein plasma.
N'ime ọmụmụ anụmanụ, enweghị nchịkọta nke ngwa nkwadebe Augmentin® na akụkụ ọ bụla achọtara.
Amoxicillin, dị ka ọtụtụ penisiliniins, na-abanye n'ime mmiri ara. A nwekwara ike ịchọta akụkụ nke clavulanic acid na mmiri ara. Ewezuga ohere nke ọgụgụ isi, afọ ọsịsa na candidiasis nke akpụkpọ ahụ mucous, enweghị mmetụta ndị ọzọ nke amoxicillin na clavulanic acid na ahụike nke ụmụaka na-enye ara.
Ọmụmụ banyere ọmụmụ ụmụ anụmanụ egosila na amoxicillin na clavulanic acid na-agafe ihe mgbochi placental. Agbanyeghị, ọ nweghị mmetụta dị njọ na nwa ebu n’afọ achọpụtara.
Metabolism
10-25% nke ọgwụ mbu nke amoxicillin na-apụ n’arụ n’ụdị metabolite na-adịghị arụ ọrụ (penisilloic acid). Clavulanic acid bụ metabolized nke 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid na 1-amino-4-hydroxybutan-2-otu ma kpụrụ ya na akụrụ yana ikuku kuuru n'ụdị carbon dioxide.
Ojiji
Dị ka ọgwụ penicillins ndị ọzọ, amoxicillin na-apụkarị site na akụrụ, ebe a na-ahụ ọgwụ clavulanic acid site na usoro gbasara akụrụ na extrarenal. Ihe dị ka 60-70% nke amoxicillin na ihe dị ka 40-65% nke clavulanic acid bụ nke akụrụ na-agbanweghi agbanwe n’ime awa 6 mbụ mgbe ha nwesịrị 1 mbadamba 250 mg / 125 mg ma ọ bụ mbadamba 500 nke 500 mg / 125 mg. Nlekọta nke probenecid n’otu oge ga-akwụsịlata mmịpụta nke amoxicillin, mana ọbụghị clavulanic acid (lee mpaghara “Mmekọrịta na ọgwụ ndị ọzọ”).

EGO NA-EGO

Nje virus nke bakteria na-akpata site na microorganisms nwere mmetụta amoxicillin / clavulanic acid:
• Ọrịa ENT, dịka ụkwara ume ọkụ ugboro ugboro, sinusitis, otitis media, nke ihe na-ebutekarị site na Streptococcus pneumoniae, influenza nke Haemophilus, Moraxella catarrhalis, na pyogenes Streptococcus.
• Ọrịa oluku na-efe efe dị ala, dị ka ọrịa ụkwara ume ọkụ na-adịghị ala ala, akwara lobar, na bronchopneumonia, nke na-ebutekarịkarị akpukpo ọrịa Symptococcus, Haemophilus influenzae, na Moraxella catarrhalis.
• Ọrịa Urogenital tract, dị ka cystitis, urethritis, pyelonephritis, ọrịa nke ụmụ nwanyị, na-ebutekarị site na ụdị nke ezinụlọ Enterobacteriaceae (ọkachasị nke Escherichia coli), staphylococcus saprophyticus na ụdị mkpụrụ ndụ ihe nketa Enterococcus, yana gonorrhea nke Neisseria gonorrhoeae kpatara.
• Ọrịa nke anụ ahụ na anụ ahụ dị nro, nke Staphylococcus aureus na-akpata, na-akpata plogenes Streptococcus, na ụdị mkpụrụ ndụ ihe nketa Bacteroides.
• Ọrịa nke ọkpụkpụ na nkwonkwo, dị ka osteomyelitis, nke Staphylococcus aureus na-akpata, ọ bụrụ na ọ dị mkpa ịgwọ ogologo oge.

Ọrịa Augmentinfections nwere ike ịgwọ ọrịa na-efe efe nke microorganisms na-akpata, ebe ọ bụ na amoxicillin bụ otu n'ime ihe ndị dị na ya.

NWAANYI ANA EGO

• Hypersensitivity na amoxicillin, clavulanic acid, ihe ndị ọzọ dị na ọgwụ ahụ, ọgwụ mgbochi beta-lactam (dịka ọmụmaatụ, penisiliniins, cephalosporins) na anamnesis,
• ihe ndị na-eme jaundice n'oge gara aga ma ọ bụ ọrụ imeju na-arụ ọrụ mgbe ị na-ejikọkọta amoxicillin na clavulanic acid na anamnesis,
• afọ ụmụaka ruo ọnwa atọ,
• arụ ọrụ na-arụ ọrụ na-arụ ọrụ nke oma (nwechapụ ihe na-erughị 30 ml / min),
• phenylketonuria.

AKPLKỌ AKW DKWỌ DBRER P MGBE EGO NA-EKWETA

Ime
N'ime omumu banyere oru omumu na anumanu, onu na ochichi nke Augmentin® emeghi teratogenic.
N'ime otu nnyocha ụmụ nwanyị nwere membranes akatabeghị aka, achọpụtara na ọgwụ ọgwụ prophylactic nwere ike ịnwe n'ihe egwu dịkwuo elu nke necrotizing enterocolitis n'ime ụmụ amụrụ ọhụrụ. Dị ka ọgwụ niile, a naghị atụ aro Augmentin® maka oge a dị ime, belụsọ na uru nne elere anya nne ga-akacha n'ihe nwa ebu n’afọ.
Oge ara
Enwere ike iji ọgwụ Augmentin® mee ihe n’oge a na-enye nwa ara. Ewezuga ohere nke ịmata mmụọ, afọ ọsịsa, ma ọ bụ candidiasis nke akpụkpọ ahụ mucous n'ụdị metụtara nnabata nke ọnya ọgwụ a n'ime mmiri ara, ọ nweghị mmetụta ọjọọ ndị ọzọ hụrụ na ụmụ a na-enye ụmụ ara. N'ọnọdụ nke mmetụta ọjọọ n'ime ụmụ a na-enye nwa ara, a ga-akwụsị ịhapụ inye ụmụaka ara.

OSM ANDAKA NA ỌM .AKA

Maka nchịkwa ọnụ.
A na-edobe usoro usoro onunu ogwu n'otu oge dabere na afọ, oke ahụ, ọrụ akụrụ nke onye ọrịa, yana ogo ọrịa ahụ.
Iji belata nsị nke oghere ga-ekwe omume na iwelata ohere ị ,ụ mmanya, a ga-a drugụ ọgwụ ahụ na mbido nri.
Ọgwụ opekempe nke ọgwụ nje na - ụbọchị 5.
Ọgwụ ekwesịghị ịga n’ihu karịa ụbọchị iri na anọ na-enweghị nyocha banyere ọnọdụ ụlọ ọgwụ.
Ọ bụrụ na ọ dị mkpa, a ga - enwe ike ịme usoro ọgwụgwọ site na ị ga - eme (usoro nchịkwa mbụ nke nkwadebe Augmentin® n'ụdị usoro ọgwụgwọ bụ ntụ maka ịkwadebe ihe ngwọta maka nchịkwa intravenous na ntughari na - esote na nkwadebe Augmentin® n'ụdị usoro onunu ogwu).
Ndị okenye na ụmụaka gbara afọ 12 gbagoro ma ọ bụ karịa 40 n'arọ ma ọ bụ karịa
Ọ na-atụ aro ka iji ụdị ọgwụ tigment ndị ọzọ nke Augmentin® ma ọ bụ 11 ml nke nkwusioru na usoro nke 400 mg / 57 mg na 5 ml, nke ya na mbadamba 1 nke Augmentin®, 875 mg / 125 mg.
Agedmụaka dị n’agbata ọnwa atọ ruo afọ iri na abụọ n’arụ ahụ́ ya erughị 40 n'arọ
A na-eme ngụkọta usoro dabere na afọ na oke ahụ, nke egosipụtara na mg / n'arọ ahụ kwa ụbọchị ma ọ bụ na nkwụsị nke milliliters. A na-ekewa ụbọchị kwa ụbọchị ụzọ abụọ dị kwa awa iri abụọ. Usoro usoro usoro onunu ogwu a ka akwadoro ka ana egosiputa ya na oge oru ya na tebulu di n'okpuru.
Tebụl Augmentin® dosing regimen (ịgbakọ ịgbakọ maka amoxicillin)

Nkwusioru 7: 1 (200 mg / 28.5 mg na 5 ml ma ọ bụ 400 mg / 57 mg na 5 ml) na 2 usoro oge ọ bụla awa 12 ọ bụla.
Doses dị ala 25 mg / kg / ụbọchị
Doses dị elu 45 mg / kg / ụbọchị

A na-atụ aro iji obere Augmentin® maka ọgwụgwọ nke ọrịa anụ ahụ na anụ ahụ dị nro, yana tonsillitis ugboro ugboro.
A na-akwado ọgwụ ka ukwuu nke Augmentin® maka ịgwọ ọrịa dịka otitis media, sinusitis, ọrịa nke akụkụ okuku ume na akwara, ọrịa nke ọkpụkpụ na nkwonkwo.
Maka ọgwụ Augmentin® nke nwere ọgwụ amoxicillin na clavulanic acid 7: 1, enwere data ezughi oke nke ulo ogwu iji kwado ojiji nke ihe kariri 45 mg / kg / day na onunu abuo n’ime umuaka n’agbata afọ 2.
Umuaka site na omumu rue onwa ato
Iji nkwusioru ya na oke nke amoxicillin na clavulanic acid 7: 1 (200 mg / 28.5 mg na 5 ml na 400 mg / 57 mg na 5 ml) bụ contraindicated na ndị a.
Umu aka
Enweghị ntuziaka maka usoro usoro usoro onunu ogwu.
Ndị otu ọrịa pụrụ iche
Ndị okenye na-arịa ọrịa
Achọghị usoro maka usoro onunu ogwu; otu usoro usoro usoro ọgwụgwọ ahụ ka eji eme ya na ndị ọrịa okenye. N'ime ndị ọrịa agadi nwere ezumike ọrụ ezumike, a na-enye usoro ọgwụgwọ kwesịrị ekwesị maka ndị ọrịa toro eto nwere ọrụ mgbazi arụ.
Ndị ọrịa nwere ọrụ mgbazinye nsogbu
Ekwesịrị iji nkwusioru 7: 1 (200 mg / 28.5 mg na 5 ml ma ọ bụ 400 mg / 57 mg na 5 ml) naanị na ndị ọrịa nwere njigide creatinine karịa 30 ml / min, na-enweghị mgbanwe usoro onyunyo chọrọ.
N'ọnọdụ ka ukwuu, ọ bụrụ na ọ ga-ekwe omume, a ga-ahọrọ usoro ọgwụgwọ nke ihe na-ahụ maka ọrịa nwa oge.
Ndị ọrịa nwere ọria imeju
A na- eji nlezianya na-agwọ ọgwụgwọ; a na-enyocha ọrụ imeju.
Enweghi data zuru oke iji gbanwee ntuziaka ọgwụ ndị a na ndị ọrịa dị.
Ofzọ nkwadebe nke nkwusioru
A kwadebere nkwusioru ya ozugbo tupu ojiji izizi.
Ekwesịrị ịgụnye ihe dị ka milimita 40 nke esi esi mmiri ruo n'ime ụlọ dị n'ime karama ntụ, wee mechie karama ahụ na mkpuchi wee maa jijiji ruo mgbe ntụ ọka ahụ kpamkpam, kwe ka karama ahụ kwụrụ ruo minit 5 iji hụ na ngwakọta zuru ezu. Tinye mmiri n’ime akara n’ime karama ahụ ma gbanye karama ahụ ọzọ. Na mkpokọta, a chọrọ ihe dị ka 64 ml mmiri iji kwadebe nkwusioru.
Ekwesịrị imebi karama ahụ nke ọma tupu ojiji ọ bụla. Maka ịsingụ ọgwụ ọ bụla nke ọma, jiri okpu ị na-eji atụ ma ọ bụ nke dotes, nke a ga-eji mmiri saa ahụ nke ọma.Mgbe dilution, ekwesịrị ịchekwa nkwụsị ahụ ihe na-erughị ụbọchị 7 na friji, mana ọ bụghị kpọnwụrụ.
Maka ụmụaka na-erubeghị afọ abụọ, a pụrụ iji mmiri tụọ n ’ọgwụ Augmentin® tụọ otu ọgwụ ụrọ ga-abụ mmiri site na 1: 1.

Mwepụta wepụtara ya na ihe mejupụtara

Ọgwụ nje dị n'ụdị ndị a:

Mbadamba ihe eji eme ihe nkiri: oval, ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha, na mgbaji - si na-acha ọcha-acha odo odo ruo ihe fọrọ nke nta ka ọ bụrụ ọcha na 250 mg ọ bụla (250 + 125): nke e dere ihe edepụtara n'otu mbadamba AUGMENTIN (na blisters nke 10 PC. katọn mkpọ 2 blisters), 500 mg ọ bụla (500 + 125): na ihe e dere ede "ext" yana ihe egwu dị n'otu akụkụ (na blisters nke 7 ma ọ bụ 10 PC., na mkpọ katọn 2 blisters), 875 mg (875 + 125) ): site na mkpụrụedemede "A" na "C" n'akụkụ mbadamba mbadamba ya na ihe ọghọm nke mgbaji n'otu akụkụ (na blisters nke 7 PC., na ngwugwu nke ngwugwu 2).
ntụ ntụ maka nkwusioru maka nchịkwa ọnụ: na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha, nwere njirimara mara mma, mgbe diluted, a na-enweta nkwusioru (ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke ọcha), nke a na-eburu ibu na ezumike (na karama iko, karama 1 na okpu na-eji atụ na igbe kaadi) ,
ntụ ntụ maka ihe ngwọta maka nchịkwa ọbara: site na ọcha ruo ihe fọrọ nke nta ka ọ bụrụ ọcha (na ngwugwu kaadiboodu 10).

Augmentin na-ejikọta ọgwụ clavulanic acid (n'ụdị nnu nnu) yana amoxicillin (n'ụdị nnu sodium).

Otu mbadamba 1 nwere:

bekee na-arụ ọrụ: clavulanic acid - 125 mg, amoxicillin (dị ka trihydrate) - 250, 500 ma ọ bụ 875 mg,
ndị na - ahụkarị: sodium carboxymethyl stachi, sillofon silikoni dioxide, magnesium stearate, microcrystalline cellulose.

Nhazi nke ihe eji eme ihe nkiri na mbadamba ihe gụnyere: hypromellose, hypromellose (5cP), macrogol 6000, macrogol 4000, dimethicone, titanium dioxide.

5 ml nke nkwusioru a kwadebere maka nchịkwa ọnụ nwere:

ihe ndị na-arụ ọrụ bụ oke nke amoxicillin (n'ụdị trihydrate) nye clavulanic acid (n'ụdị nnu nnu): 125 mg / 31.25 mg, 200 mg / 28.5 mg, 400 mg / 57 mg,
ndị na - ahụkarị: hypromellose, xanthan gum, succinic acid, aspartame, silloon silicon dioxide, ihe ndị na-atọ ụtọ (oroma 1, oroma 2, rasberi, "Molasses na-acha ọcha"), silicon dioxide.

1 vial (1200 mg) nke usoro ọgwụgwọ nwere ihe dị n’ime ya nwere:

amoxicillin (n'ụdị nnu sodium) - 1000 mg,
acid clavulanic (n'ụdị nnu nnu) - 200 mg.

Mlọ ọgwụ

Amoxicillin bụ ọgwụ mgbochi ụrọ nke semisynthetic nke na - arụ ọrụ megide ọtụtụ microorganisms gram-negative na gram-gram-gram. Agbanyeghị, amoxicillin nwere ike ibute mbibi site na β-lactamases; yabụ, ụdị ọrụ ya adịghị emetụta ndị nje na - emepụta enzyme a.

Clavulanic acid nwere ihe yiri penicillins ma bụrụkwa ihe mgbochi β-lactamases, na-akọwa ike ya inachibido a-lactamases dị iche iche, nke dị na microorganisms nke na-egosi iguzogide cephalosporins na penisiliniins. Akụkụ a dị ike na-arụ ọrụ na plasmid ct-lactamases, nke a na-enyekarị nje na-eguzogide ọgwụ, ọ nweghịkwa arụ ọrụ megide ụdị ọgwụ chromosome ases-lactamases nke 1 nke ọgwụ clavulanic na-egbochi.

Ntinye nke clavulanic acid na ihe mejupụtara nke Augmentin na-enye gị ohere ichebe amoxicillin site na mbibi site na enzymes - β-lactamases, nke na-ahụ maka mgbasawanye nke ụdị nje ihe a.

Na vitro, microorganisms ndị a na-eche banyere nchikota nke amoxicillin na clavulanic acid:

gram-ọjọọ aerobes: Vibrio cholerae, Bordetella pertussis, Pasteurella multocida, Haemophilus influenzae, Neisseria gonorrhoeae, Moraxella catarrhalis, Helicobacter pylori,
Aerobes dị mma: ihe staagọ nke na-adịghị mma (stainslococcus saprophyticus) nke na-egosipụta mmetụta uche na methicillin, staphylococcus aureus (na-egosipụta mmetụta nke methicillin), Bacillus anthracis, Streptocococcus agal. (ọzọ stre-hemolytic streptococci), pyogenes Streptococcus, Enterococcus faecalis, Nocardia asteroides, Listeria monocytogenes,
gram-odi anaerobes: Prevotella spp., Bacteroides fragilis, Bacteroides spp., Porphyromonas spp., Fusobacterium spp., Fusobacterium nucleatum, Eikenella corrodens, Capnocytophaga spp.,
anaerobes gram-positive: Peptostreptococcus spp., Peptostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus niger, Clostridium spp.,
Ndị ọzọ: Treponema pallidum, Leptospira icterohaemorrhagiae, Borrelia burgdorferi.

Ejiri microorganism ndị a bụ nke enwetara na nguzogide na nchikota nke amoxicillin na clavulanic acid:

gram-aerobes ọma: streptococci nke ndị otu nje, Corynebacterium spp., pịrịoniae Streptococcus (nje nke ụdị nje a anaghị emepụta β-lactamases, na ọgwụgwọ nke ọgwụ ahụ ka enwetara site na nsonaazụ nke ọmụmụ ụlọ ọgwụ), Enterococcus faecium,
gram-negative aerobes: Shigella spp., Escherichia coli, Salmonella spp., Klebsiella spp., Klebsiella poniaoniae, Klebsiella oxytoca, Proteus spp., Proteus vulgaris, Proteus mirabilis.

Mkpụrụ nje ndị na-esonụ na-eguzogide ọgwụ n'ụzọ nkịtị, nke gụnyere amoxicillin na clavulanic acid:

gram-negative aerobes: Yersinia enterocolitica, Acinetobacter spp., Stenotrophomonas maltophilia, Citrobacter freundii, Serratia spp., Enterobacter spp., Pseudomonas spp., Hafnia alvei, Providencia spp., Morganella morganii
ozo: Coxiella burnetii, Chlamydia psittaci, Chlamydia poniaoniae, Chlamydia spp., Mycoplasma spp.

Nzuzo nke pathogen ka montherapy amoxicillin na-enye echiche yiri nke ahụ na njikọta nke amoxicillin na clavulanic acid.

Mlọ ọgwụ

Clavulanic acid na amoxicillin na-agbakarị ọsọ ọsọ ma ihe fọrọ nke nta ka ọ bụrụ 100% na-etinye obi gị dum na eriri afọ (GIT) mgbe a na-ewere ya ọnụ. A na-ewere nnabata nke ihe ndị na-arụ ọrụ nke Augmentin kachasị mma mgbe ọgwụ na-abanye n'ahụ ahụ na mmalite nri.

A gụrụ ojiji nke nkwusioru maka nchịkwa ọnụ na ule nke ụlọ ọgwụ ebe ndị ọrụ afọ ofufo dị mma dị afọ 2 ruo afọ 12 sonyere. Ha were Augmentin na onunu ogwu nke ọgwụ mgmillin 125 mg / 31,25 5 ml na afọ na-enweghị nri na usoro 3 kewara, yana ọgwụ kwa ụbọchị nke amoxicillin na clavulanic acid nke 40 na 10 mg / kg, n'otu n'otu. N'ihi nnwale ahụ, enwetara usoro ọgwụ ọgwụ ndị a:

clavulanic acid: ịta kachasị nke 2.7 ± 1.6 mg / ml, oge iji ruo ihe dịkarịsịrị mkpa nke plasma nke 1.6 awa (awa 1-2), AUC 5.5 ± 3.1 mg × h / ml, iwepu ọkara ndụ nke 0.94 ± 0.05 awa,
amoxicillin: ịta kachasị 7.3 ± 1.7 mg / ml, oge iji rute ihe kachasị plasma ọdịnaya 2.1 awa (awa 1.2-3), AUC 18.6 ± 2.6 mg × h / ml Iwepu ọkara ndụ 1.0 ± 0.33 awa.

Emekwara ọmụmụ ihe gbasara njirimara nke pharmacokinetics nke Augmentin mgbe a na-ewere ya n'ụdị mbadamba, mbadamba ihe nkiri (na afọ efu). Nsonaazụ nke ikpebi ọgwụ pharmacokinetic dabere na oriri nke Augmentin, clavulanic acid na amoxicillin na usoro onunu ogwu di iche iche:

otu mbadamba Augmentin nwere usoro nke 250 mg / 125 mg: maka amoxicillin - oge kachasị 3.7 mg / l, oge iji ruo ogo kachasị elu nke plasma nke awa 1.1, AUC (mpaghara dị n'okpuru usoro "ịta - oge") 10.9 mg × h / ml ọkara ndụ (T_1/2) 1 awa. Maka clavulanic acid, itinye uche kachasị bụ 2.2 mg / l, oge iji ruo ntinye uche kachasị na plasma ọbara bụ 1.2 awa, AUC 6.2 mg × h / ml, T_1/2 - 1,2 elekere
mbadamba Augmentin abụọ nwere usoro ọgwụ nke 250 mg / 125 mg: maka amoxicillin - oge kachasị 5.8 mg / l, oge ị ga-erute ịta ọkwa plasma kachasị nke awa 1.5, AUC 20.9 mg × h / ml, T_1/2 - 1.3 awa. Maka clavulanic acid, itinye uche kachasị bụ 4.1 mg / L, oge iji ruo ogo ịta ahụhụ kachasị elu bụ awa 1.3, AUC 11.8 mg × h / ml, T_1/2 - 1 awa
otu mbadamba Augmentin nke nwere ọgwụ nke 500 mg / 125 mg: maka amoxicillin - oge kachasị 6.5 mg / l, oge iji ruo ogo ịta Plasma kachasị nke awa 1.5, AUC 23.2 mg × h / ml, T_1/2 - 1.3 awa. Maka clavulanic acid, ntinye uche kachasị bụ 2.8 mg / l, oge iji ruo ntinye uche kachasị na plasma ọbara bụ awa 1.3, AUC 7.3 mg × h / ml, T_1/2 - 0.8 awa
amoxicillin dị iche na nha 500 mg: ịta kachasị 6.5 mg / l, oge iji ruo ogo ịta Plasma kachasị 1.3 awa, AUC 19.5 mg × h / ml, T_1/2 - 1.1 awa
clavulanic acid naanị na dose nke 125 mg: ịta kachasị 3.4 mg / l, oge iji ruo ogo plasma kachasị elekere 0.9 awa, AUC 7.8 mg × h / ml, T_1/2 - 0.7 awa.

Enyochakwara ọgwụ pharmacookinetics nke ọgwụ ahụ na nchịkwa bolus nke Augmentin na ndị ọrụ afọ ofufo nwere ahụike. N'ihi ya, enwetara usoro ọgwụ ọgwụ ndị a dabere na dose:

usoro onunu ogwu 1000 mg / 200 mg: maka amoxicillin - ntinye uche kacha nke 105.4 μg / ml, T_1/2 - 0.9 awa, AUC 76.3 mg × h / ml, dị na mmamịrị n'ime oge 6 nke izizi ka nchịkwa nke 77.4% nke ihe na-arụ ọrụ. Maka clavulanic acid, itinye uche kachasị bụ 28.5 μg / ml, T_{1/2 –} 0,9 awa, AUC 27,9 mg × h / ml, nke dị na mmamịrị n'ime awa isii izizi ka nchịkwa nke 63.8% nke ihe na - arụ ọrụ,
usoro onunu ogwu nke 500 mg / 100 mg: maka amoxicillin - ntinye uche kacha nke 32.2 μg / ml, T_1/2 - 1.07 awa, AUC 25.5 mg × h / ml, dị na mmamịrị n'ime awa isii izizi ka nchịkwa nke 66.5% nke ihe arụ ọrụ. Maka clavulanic acid, itinye uche kachasị bụ 10.5 μg / ml, T_1/2 - Elekere 1,12, AUC 9.2 mg × h / ml, dị na mmamịrị n'ime oge awa isii izizi ka nchịkwa 46% nke ihe na-arụ ọrụ.

A ga - ekpebi ma a na - aralụ ya ọnụ na n'ime ya, clavulanic acid na amoxicillin na mkpokọta ọgwụgwọ na - ekpebisi ike na oghere dị iche iche (n'ime akwara afọ, anụ ahụ na uru ahụ, anụ ahụ, ọnya ọnya, mwepụ ụsọ, akwara mmiri, peritoneal na synovial) mmanya).

Ngwaọrụ abụọ na-arụ ọrụ nke Augmentin na-ejikọ ike na protin plasma. Nsonaazụ nyocha gosiri na ogo nke ijikọ amịlịillin na protein plasma bụ ihe dịka 18%, yana clavulanic acid - 25%. Nnwale anụmanụ anaghị akwado nnabata ihe ndị dị n’ime anụ ahụ ọ bụla.

Amoxicillin na-abanye n’ime mmiri ara ara, nke na-ekpebi acid clavulanic n’ime ọnya ịkpa. Achọpụtaghị mmetụta ọjọọ nke ihe ndị a na ahụike nke ụmụaka ara, na mgbakwunye na mmepe nke candidiasis nke akpụkpọ ahụ mucous nke ọnụ, afọ ọsịsa na ihe ize ndụ nke ịmata ihe.

Ihe omumu banyere omumu n’ime umu anumanu mgbe iji amoxicillin tinye ya na clavulanic acid gosiputara na ihe ndi no n’oru n’ime Augmentin na abanye n’ime ihe mgbochi, ma n’enweghi nsogbu na nwa ebu n’afọ.

Site na 10 ruo 25% nke ọgwụ a na-anabata ọgwụ nke amoxicillin bụ nke dị na mmamịrị n'ụdị penisilloic acid, metabolite na-anaghị egosipụta ọrụ ọgwụ. Clavulanic acid nwere metabolized nke ukwuu, na-akpụ 1-amino-4 hydroxy-butan-2-one na 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid, ma wepụta ya site na eriri afọ eriri afọ. , na mmamịrị, yana iji ikuku kuuru n'ụdị carbon dioxide.

Amoxicillin bụ ihe akpụrụ akpụ site na akụrụ, ebe clavulanic acid bụ ihe ejiri mara site na akụrụ na obere usoro. Ihe dị ka 45-65% nke clavulanic acid na ihe dị ka 60-70% nke amoxicillin na-agbanwegharị na mmamịrị n'ime awa isii mbụ mgbe ị nwesịrị mbadamba ụrọ nke 500 mg / 125 mg ma ọ bụ 250 mg / 125 mg ma ọ bụ mgbe otu mkpụrụ ọgwụ bolus nke Augmentin na usoro nke 500 mg / 100 mg ma ọ bụ 1000 mg / 200 mg. Nlekọta nke probenecid na-eme n'otu oge na-egbochi excretion nke amoxicillin, mana anaghị emetụta mpụta nke clavulanic acid.

Ihe ngosi maka ojiji

Dịka ntuziaka ahụ si dị, Edere Augmentin maka nje ọrịa nje nke microorganisms mere na-emetụta ọgwụ:

ọrịa akpụkpọ, anụ ahụ dị nro,
ọrịa okuku ume na akwara: bronchitis, lobar bronchopneumonia, empyema, ọnya afọ,
oria nke sisitemu akwara: cystitis, urethritis, pyelonephritis, sepsis ite ime, syphilis, gonorrhea, ọrịa nke akụkụ ahụ na mpaghara pelvic,
ọrịa metụtara ọkpụkpụ na nkwonkwo: osteomyelitis,
odontogenic na-efe efe: periodontitis, odontogenic maxillary sinusitis, nnukwu eze ezumike,
ọrịa na-ebilite dị ka mgbagha mgbe ịwachara ahụ: peritonitis.

Ihe ngbanwe

hypersensitivity na clavulanic acid, amoxicillin, ihe ndị ọzọ dị na ọgwụ na ọgwụ mgbochi beta-lactam (cephalosporins, penisilini) na anamnesis,
ikpe gara aga nke jaundice ma ọ bụ dysfunction imeju mgbe ị na-eji ngwakọta nke clavulanic acid na amoxicillin na akụkọ ihe mere eme.
arụ ọrụ ezumike mkpị (ntụ ntụ maka ịkwadebe nkwusioru maka nchịkwa ọnụ nke 200 mg / 28.5 mg na 400 mg / 57 mg, mbadamba 875 mg / 125 mg),
phenylketonuria (ntụ ntụ maka nkwusi okwu ọnụ).

Contraindications na Augmentin maka ụmụaka: mbadamba - ruo afọ 12 na ịdị arọ nke anụ ahụ erughị 40 n'arọ, ntụ ntụ maka nkwụsị ọnụ 400 mg / 57 mg na 200 mg / 28.5 mg - ruo ọnwa atọ.

Ọ bụrụ na arụ ọrụ imeju na-adịghị mma, ekwesịrị iji nlezianya mee ihe Augmentin.

N’ime afọ ime ma na-a breastụ ara, ọ bụ ndị dibia bekee na-eme mkpebi ahụ banyere iji ọgwụ a eme ihe.

Ntuziaka maka iji Augmentin: usoro na usoro onunu ogwu

Tupu nhọpụta nke Augmentin, a na-atụ aro ka ọ gaa nyocha iji chọpụta mmetụta microflora kpatara nke kpatara ọrịa a na ọgwụ nje a. Ọzọ, dọkịta ahụ wepụtara usoro onunu ogwu echebara afọ onye ọrịa, ibu, ọrụ akụrụ ya na ogo ọrịa ahụ.

Usoro ọgwụgwọ kachasị dị ala bụ ụbọchị 5, oge kachasị nke ọgwụgwọ na-enweghị idozigharị ọnọdụ ụlọ ọgwụ bụ izu abụọ. Were ọgwụ na mbido nri.

Ọ bụrụ na ọ dị mkpa, oge izizi a na-eji ọgwụ ọgwụ eme ihe ngwa ngwa, mgbe ahụ enwere ike ịkọwa nchịkwa ọnụ.

Usoro a tụrụ aro ka ị na-ewere mbadamba Augmentin maka ụmụaka gbara afọ 12 na ndị okenye:

ọ bụrụ na ọrịa na-efe efe dị nro ruo n'ogo: 1 mbadamba (250 mg + 125 mg) ugboro atọ n'ụbọchị,
maka ọrịa dị egwu ma ọ bụ nke na-adịghị ala ala: 1 mbadamba (500 mg + 125 mg) 3 ugboro n'ụbọchị ma ọ bụ mbadamba 1 (875 mg + 125 mg) 2 ugboro n'ụbọchị.

Ihe dị mkpa: 2 mbadamba 250 mg / 125 mg ezughị 1 mbadamba 500 nke 500 mg / 125 mg.

Usoro a tụrụ aro ka ị na-ewere nkwụsị Augmentin:

ụmụaka karịrị afọ 12 na ndị okenye: 11 ml nke nkwụsị nke 400 mg / 57 mg / 5 ml 2 ugboro n'ụbọchị (kwekọrọ na 1 mbadamba 875 mg + 125 mg),
umuaka site na onwa ato rue afo iri na abuo (na-adi ihe ruru 40 n'arọ): a na-ekpebi ihe a na-eme kwa ụbọchị dabere n ’ibu ahụ yana afọ (na ml maka nkwụchi, ma ọ bụ mg / kg / ụbọchị). Ekwesịrị ịgbakọ ọnụ gbakọọ ụzọ 3 n'ime oge elekere 8 (maka nkwụsị nke 125 mg / 31.25 mg / 5 ml), ma ọ bụ usoro 2 (maka nkwụsị nke 400 mg / 57 mg / 5 ml ma ọ bụ 200 mg / 28.5 mg / 5 ml) na nkeji iri na abụọ. Maka nkwusioru nke 125 mg / 31.25 mg / 5 ml, obere * doses - 20 mg / n'arọ / ụbọchị, oke nke doses ** - 40 mg / kg / ụbọchị. Maka nkwusioru nke 400 mg / 57 mg / 5 ml na 200 mg / 28.5 mg / 5 ml, usoro onyonyo dị ala bụ 25 mg / kg / ụbọchị, usoro dị elu bụ 45 mg / kg / ụbọchị.

A na-eji doses dị ala na ọgwụgwọ nke tonsillitis ugboro ugboro na ọrịa nke anụ ahụ dị nro na anụ ahụ.

** A choro otutu doses na ọgwụgwọ nke sinusitis, otitis media, ọrịa nke nkwonkwo na ọkpụkpụ, urinary na tract respiratory.

Ngwọta ọgwụ Augmentin tụrụ aro n'ụdị ihe ga - eme ka ọchịchị ọgbụgba dị iche iche (iv):

ụmụaka karịrị afọ 12 na ndị okenye: 1000 mg / 200 mg ugboro atọ kwa ụbọchị (awa asatọ ọ bụla), na nnukwu ọrịa, enwere ike belata oge dị n'etiti injections ruo awa 4-6.
ụmụaka site na ọnwa 3 ruo afọ 12: ugboro 3 kwa ụbọchị na ọnụego nke 50 mg / 5 mg / kg ma ọ bụ 25 mg / 5 mg / n'arọ dabere ogo nke ọrịa ahụ, etiti oge dị n'etiti injections bụ 8 awa,
ụmụaka na-erubeghị ọnwa atọ: na-enwe ahụ ihe karịrị 4 n'arọ - 25 mg / 5 mg / n'arọ ma ọ bụ 50 mg / 5 mg / n'arọ kwa awa 8, na ahụ ha erughị 4 n'arọ - 25 mg / 5 mg / kg kwa awa iri na abụọ.

Ekwesịrị ịhapụ Augmentin kpam kpam na usoro onunu ogwu nke dọkịta nyere, na-elele usoro usoro onunu ogwu edepụtara.

Nsonaazụ

Ojiji nke Augmentin na-adịghị ahụkebe nwere ike ibute nsonaazụ ndị a (ọkachasị dị nro na obere).

sisitemu hematopoietic: thrombocytopenia, leukopenia (gụnyere neutropenia), hemolytic anaemia na agranulocytosis (weghachite), mmụba na prothrombin index na oge ọbara ọgbụgba,
dịghịzi usoro: mmeghachi omume nfụkasị ụdị anaphylaxis, angioedema, ọrịa yiri ọrịa serum, Stevens-Johnson syndrome, nfụkasị vasculitis na-egbu egbu, necrolysis na-egbu egbu, ọrịa exfoliative buru ibu, nnukwu ịba ụba exanthematous pustulosis. A ga-akwụsị ịhapụ Augmentin ma ọ bụrụ n'ụdị nfụkasị ọ bụla.
ekpughere anụ ahụ: ihe ọkụ ọkụ, urticaria, erythema multiforme,
sistemu akwara: ụjọ na-atụ na nkwarụ (atụgharịrị), isi ọwụwa, ọgbụgbọ,
imeju: cholestatic jaundice, ịba ọcha n'anya, mmụba na-abawanye na ACT na / ma ọ bụ ọkwa ALT (mmetụta ndị a na-apụta n'oge ọgwụgwọ ma ọ bụ ozugbo ọ gasịrị, ọtụtụ mgbe na ndị ọrịa agadi na ụmụ nwoke (na ọgwụgwọ ogologo oge), na ụmụaka - ọ na-adịghị ahụkebe, ma bụrụ Ntụgharị)
sis urinary: crystalluria, nephritis interstitial.

Ọtụtụ mgbe, iji Augmentin nwere ike ibute ọrịa shuga na ndị okenye na ụmụaka, ọgbụgbọ, ọgbụgbọ, dyspepsia (enwere ike belata nsogbu ndị a ma ọ bụrụ na ị theụọ ọgwụ ahụ).

N’oge ufodu, n’ime umuaka ndi butere Augmentin nkwusi, agba nke akpukpo isi ahu nwere ike gbanwee.

Mmetụta microbiological nke ọgwụ na-akpatakarị candidiasis nke akpụkpọ ahụ mucous, n'ọnọdụ ndị dị obere ọ nwere ike ibute ọgbụgba na pseudomembranous colitis.

Ngwongwo ogwu

Mlọ ọgwụ
Usoro nke ime ihe
Amoxicillin bụ ọgwụ penicillin (beta-lacgam) nke na-egbochi otu ma ọ bụ karịa (amara dị ka penisillin-protein na-egbochi) n'oge biosynthesis nke peptidoglycan nje na-akpata, nke bụ ihe na-eme ka njikọta nke mgbidi cell ahụ bakteria. Ihe mgbochi nke njikọ peptidoglycan na-eduga ná nyocha nke mgbidi ụlọ, nke na-esote na-akpata nyocha na ọnwụ sel.
A na-emebi ọgwụ ndị na-egbochi ọgwụ beta-lactamases site na beta-lactamases, yabụ na ụdị ọrụ nke amoxicillin n’onwe ya adịghị etinye microorganisms nke na-emepụta enzyme ndị a.
Clavulanic acid bụ beta-lactamase inhibitor nke metụtara penisilini. Clavulanic acid na-egbochi ihe ụfọdụ enzymes beta-lactamase, si otú a na-egbochi itinye aka nke amoxicillin. Clavulanic acid naanị anaghị egosipụta mmetụta ọgwụ nje dị mkpa na ọgwụ.
Mmekorita nke pharmacokinetics / pharmacodynamics
Isi ihe na-ekpebi ịdị irè nke amoxicillin bụ oge nke ịgabiga ntakịrị ntinye uche (T> IPC).
Usoro nguzobe nguzogide
E nwere ụzọ abụọ dị mkpa e hiwere isi megide amoxicillin / clavulanic acid:
• Mkpuchi nke beta-lactamases ndị ahụ nke clavulanic acid na-egbochi, gụnyere beta-lactamases nke klaasị B, C na D.
• Mgbanwe nke protein na-ejikọ penicillin, nke na-eduga n'ịbelata njikọta nke ihe ndị na-egbochi nje ihe maka ebumnuche a.
Na mgbakwunye, mgbanwe na permeability nke shei nke microorganism, yana ngosipụta nke pọmpụ pọlux, nwere ike ibute ma ọ bụ mee ka mmepe nke nguzogide nje, karịsịa na nje na-adịghị mma gram.
Ọrịa site na nje na nje bacteria na-agbanwe site na mpaghara na oge oge. Ọ bụ ihe amamihe dị na ya iburu n'uche nghọta data mpaghara, ọkachasị mgbe a bịara n'ịgwọ ọrịa dị egwu. Ekwesịrị ịkpọtụrụ ndị ọkachamara ma ọ bụrụ na data nguzobe mpaghara na-agbagha ịdị irè nke ọgwụ n'ịgwọ ụfọdụ ụdị ọrịa.
Microorganisms nwere ike ịnagide
Aerobic gram-nti microorganisms:
Enterococcus faecalis, Gardnerella vaginalis, Staphylococcus aureus, methicillin-sensitive *, coagulase-na-adịghị mma staphylococci (methicillin-mwute), Sagabactia treptococcus, Ahụike oyibo1,Ike pyogenes yana beta hemolytic streptococci, otu Nwa agbọghọ na-amaghị nwoke.
Aerobic gram-na-adịghị mma microorganisms:
Capnocytophaga spp., Eikenella corrodens, Haemophilus influenzae 2, Moraxella catarrhalis, Pasteurella multocida
Microorganisms anaerobic:
Bacteroides fragilis, Fusobacterium nucleatum, Prevotella spp.
Okike nke a na-enweta nguzogide ga-ekwe omume
Aerobic gram-nti microorganisms:
Enterococcus faecium **
Aerobic gram-na-adịghị mma microorganisms:
Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris
Ebumnuche na-egbochi nje
Aerobic gram-microorganisms
Acinetobacter sp., Citrobacter freundii, Enterobacter sp., Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas sp., Serratia sp., Stenotrophomonas maltophilia
Ihe ndị ọzọ na-akpata ahụhụ
Chlamydophilia poniaoniae, Chlamodophila psittaci, Coxiella burnetti, Mycoplasma pneumoniae.
* Staphylococci niile na-eguzogide ọgwụ na methicillin na-eguzogide amoxicillin / clavulanic acid. "Ahụrụ mmụọ dị nro na - enweghị ụdị usoro nkwụghachi azụ.
1 Augmentin ọgwụ, ntụ ntụ maka nkwụsị ọnụ, 200 mg / 28.5 mg na 5 ml na 400 mg / 57 mg na 5 ml, adabaghị maka ọgwụgwọ nke ọgwụ penicillin na-egbochi pneumoniae (lee anya) ngalaba "Usoro ọgwụgwọ na nchịkwa" na "ịkpachara anya").
2 N’obodo ụfọdụ EU, a kọtụrụla ụdị ihe na -echekarị site na uche ihe karịrị 10%.
Mlọ ọgwụ
Egwu
Amoxicillin na clavulanic acid na-agbachasị agbachasị agbanwe agbanwe na usoro ọgwụgwọ physiological pH. Akụkụ abụọ a na-abanye ngwa ngwa ma na-agbachakwa afọ site na eriri afọ (GIT) mgbe nchịkwa ọnụ gasịrị. Orhapụ ọgwụ ndị dị ike bụ ihe dị mma ma ọ bụrụ na ị takingụ ọgwụ ọjọọ ahụ na mmalite nri. Mgbe nchịkwa ọnụ gachara, bioavailability nke amoxicillin na clavulanic acid bụ 70%. Usoro ọgwụ pharmacokinetic nke ihe abụọ dị na ya yiri, oge iji ruo ogo ịta Plasma kachasị (Tmax) bụ ihe dịka elekere 1.
N'okpuru ebe a bụ nsonaazụ ọgwụ ọgwụ nke ọmụmụ nke e were mbadamba ọgwụ amoxicillin / clavulanic acid (usoro ọgwụ 875 mg / 125 mg) ugboro abụọ kwa ụbọchị na afọ efu.

Odika uru nke pharmacokinetic paramita (± agbaghari uzo)

AUC (0-244) (μg x h / ml)

Amoxicillin / clavulanic acid 875 mg / 125 mg

Dodoụbiga ya ókè

Site na mmachi nke Augmentin, mmebi nke mmiri-electrolyte nguzozi na mgbaàmà ọjọọ site na eriri afọ. Enwere akụkọ nke mmepe nke amoxicillin crystalluria, nke na ụfọdụ kpasuru mmepe nke ọdịda akwara. Ọrịa nwere ọrịa akụrụ, yana ndị na-a theụ ọgwụ ahụ elu, nwere ike ịnwe ihe ọdịdọ.

Iji kwụsị ihe na-adịghị mma metụtara ọrụ eriri afọ, a na-enye usoro ọgwụgwọ Symptomatic, na nhọpụta nke ekwesịrị ịkwụ ụgwọ nlebara anya pụrụ iche iji nwute mmezi mmiri-electrolyte. Enwere ike wepu Clavulanic acid na amoxicillin na mkpụkọ sistemu site na usoro ịkpụgharị ahụ.

Ọmụmụ ihe ọmụmụ na-aga n'ihu na ụlọ ọgwụ toxicology nke ụmụaka 51 na-esonye gosipụtara na nchịkwa nke amoxicillin na ọgwụ nke na-akarịghị 250 mg / n'arọ apụtaghị mmepe nke mgbaàmà dị ịrịba ama nke ịdoụbiga mmanya ókè ma ọ chọghị lavage gastric.

Mgbe nchịkwa akwara nke amoxicillin dị ukwuu na doses, ọ nwere ike etolite mmachi na katiders urinary, yabụ a ga-enyocha ike ha mgbe niile.

Ntụziaka pụrụ iche

N'oge ọgwụgwọ Augmentin, ọ dị mkpa ka ị buru ụzọ chịkọta akụkọ gbasara ahụike zuru ezu iji chọpụta ma enwere mmeghachi omume hypersensitivity mbụ na cephalosporins, penicillins ma ọ bụ allergens ndị ọzọ.

Mmeghari anaphylactoid mere, na-egbu egbu mgbe ụfọdụ, ka ekpesara n'ụzọ ụfọdụ. Nke puru ime ihe egwu di otua na ndi oria nwere oria na penicillins. Ọ bụrụ na ihe mmeghachi ahụ na-akpata ahụ, a ga-akwụsị ọgwụgwọ Augmentin ozugbo; n'ọnọdụ ndị siri ike, a ga-enye adrenaline ozugbo. Enwere ike inwe mkpa maka ọgwụgwọ oxygen, nhazi nke intanetị nke glucocorticosteroids, na-ejide ikikere nke ikuku, gụnyere intubation.

Site n'iji Augmentin mee ogologo oge, ihe ize ndụ nke ịmụmụ microorganisms gabigara ókè na-abawanye na ya.

Ime na lactation

Nsonaazụ nke ọmụmụ omumu na ụmụ anụmanụ nwere parenteral na nchịkwa ọnụ nke Augmentin na-akwado enweghị ọnya teratogenic nke ọgwụ ọjọọ kpatara. Otu ihe omumu, nke emere na ndi oria nke membranes na akaghi aka, na-egosi na ogwu prophylactic na ogwu a nwere ike ime ka ihe ojoo nke omumu a bu oria di egwu. Ya mere, a ga-eji Augmentin mee ihe naanị mgbe uru uru ọgwụgwọ dị na nne bara karịrị akarị nsonaazụ ụmụaka nwere ike ibute nwa ebu n’afọ.

A na-anabata nhọpụta nke Augmentin n’oge a na-enye nwa ara. Agbanyeghị, ọ bụrụ na ụmụaka etolite ihe na-adịghị mma (candidiasis nke akpụkpọ ahụ mucous nke oghere ọnụ, afọ ọsịsa, mmụba dị elu), a na-atụ aro ịkwụsị inye ara.

Jiri na nwata

A na-anabata akwụkwọ oge emere maka Augmentin maka ụmụaka dịka ihe gosiri na iji kwado usoro usoro usoro ọgwụgwọ:

ntụ ntụ maka ịkwadebe nkwusioru maka nchịkwa ọnụ na ntụ maka ịkwadebe ihe ngwọta maka nchịkwa iv - site na ọmụmụ,
Mbadamba ihe mkpuchi - site na afọ iri na abụọ.

Bụrụ na nke arụ ọrụ ezumike ọrụ

N'ime ndị ọrịa nwere dysfunction akụrụ, mmezi mmelite dabere na usoro ọgwụgwọ kachasị nke amoxicillin ma dabere na nhichapụ creatinine (CC).

Mgbe ndị okenye toro eto nwere CC dị ihe karịrị 30 ml / min, mbadamba Augmentin nwere usoro ọgwụ nke 500 mg / 125 mg ma ọ bụ 250 mg / 125 mg, yana nkwusioru ya na iji usoro ọgwụ nke 125 mg / 31.25 mg na 5 ml, ọ dịghị mkpa maka mmezi dose. Ọ bụrụ na uru QC sitere na 10 ruo 30 ml / min, a na-atụ aro ka ndị ọrịa were mbadamba 1 nke 500 mg / 125 mg ma ọ bụ mbadamba 1 nke 250 mg / 125 mg (maka ọrịa na-adịghị ala ala) 2 ugboro n'ụbọchị ma ọ bụ 20 ml nke nkwụsị nke 125 mg / 31.25 mg na 5 ml ugboro abụọ n'ụbọchị.

Site na uru CC na-erughi 10 ml / min, a na-eji Augmentin na usoro nke 1 mbadamba 500 mg / 125 mg ma ọ bụ 1 mbadamba 250 mg / 125 mg (maka ọrịa na-adịghị ala ala) 1 oge kwa ụbọchị ma ọ bụ 20 ml nke nkwụsị nke 125 mg / 31.25 mg na 5 ml otu ugboro n'ụbọchị.

A na-enye mbadamba 875 mg / 125 mg naanị maka ndị ọrịa CC nwere ihe karịrị 30 ml / min; ya mere, a chọghị ndozi dose. N'ọnọdụ ka ukwuu, akwadoro ochichi nke Augmentin ka akwadoro.

Mgbe ejiri ya na ndị okenye na ụmụaka karịrị afọ 12 ma ọ bụ karịa 40 n'arọ ndị nọ n'ọbara ha, ọgwụ a tụrụ aro ya na Augmentin bụ 1 mbadamba 500 mg / 125 mg (2 mbadamba 250 mg / 125 mg) otu ugboro kwa awa 24 ma ọ bụ 20 ml Nkwụsị 125 mg / 31.25 mg 1 oge kwa ụbọchị.

N'ime usoro nyocha ahụ, yana na njedebe ya, onye ọrịa ahụ na-anata otu mbadamba mbadamba (1 ọgwụ), nke ga-enye gị ohere ịkwụ ụgwọ maka mbelata nke mkpokọ clavulanic acid na amoxicillin na ọbara ọbara.

Mkparịta ụka ọgwụ ọjọọ

Probenecid na ọgwụ ndị yiri ya (phenylbutazone, diuretics, NSAIDs) belata tubular secretion nke amoxicillin. A akwadoghị imekota imekota oge a, ebe enwere ike ijikọ ya na ntinye na mmụba nke amoxicillin n'ọbara (ebe mkpịsịpụta akwara nke clavulanic acid anaghị adalata).

Ọgwụ Augmentin nwere ike imetụta nsonaazụ ọgwụ a na-egbu egbu, belata ịdị irè ha (ekwesịrị ịgwa onye ọrịa banyere nke a).

Agaghị eme Augmentin n’ụdị usoro ọgwụgwọ maka ọgwụ injection na ọgwụ nje aminoglycoside n’otu sirinji, n’ihi na n’ọnọdụ a ha na-atụfu ọrụ ha. Ọ bụ ihe anakwereghị ịgwakọta na ngwọta infusion nwere dextran, dextrose na sodium bicarbonate. Ejikọtara ya na ngwaahịa ọbara, yana usoro protein ndị ọzọ (protein hydrolysates), yana emulsion na-egbu egbu maka nchịkwa intravenous (iv).

Ọgwụ nje nwere otu ihe eji arụ ọrụ: Amoxiclav, Arlet, Clamosar, Bactoclav, Verklav, Liklav, Panclav, Rapiklav, Ranklav, Medoklav, Flemoklav Solutab, Ekoklav, Fibell.

Analogs nke Augmentin site na usoro nke ime ihe, ọgwụ nke otu mpaghara ọgwụ: Ampioks, Ampisid, Libakcil, Oxamp, Oxampicin, Oxamsar, Sulbacin, Sultasin, Santaz, wdg.

Usoro na ọnọdụ nchekwa

Chekwaa na okpomoku rue 25 Celsius C n’ebe okpomoku ghara inweta umu aka.

mbadamba ụrọ nke nwere amoxicillin nke 875 mg na 250 mg - afọ 2,
mbadamba nwere amoxicillin 500 mg - afọ 3,
ntụ ntụ maka ihe ngwọta maka nchịkwa ọbara - afọ 2,
ntụ ntụ maka nkwusioru n'ụdị emepere emepe - afọ 2,
nkwusioru akwadoro (na okpomọkụ n'ime 2-8 Celsius C) - 7 ụbọchị.

Nyocha banyere Augmentin

Ndị ọrịa na-ahapụ nyocha dị mma banyere Augmentin n'ụdị mbadamba na ihe mgbochi maka ụmụaka, na-akọwapụta ha dị ka ndị dị irè ma nwee ntụkwasị obi. Ogo ogo ọgwụ n’ozi ọma pụrụ iche bụ 4.3-4.5 n’ime isi 5. Ọtụtụ ndị nne na-anụ ọkụ n’obi maka nkwụchi a, n’ihi na ọ na-enye gị ohere ịnagide ọrịa ụmụaka dị ka tonsillitis ma ọ bụ bronchitis. Na mgbakwunye, nkwusioru ahụ nwere uto mara mma, n'ihi nke ụmụaka nwere mmasị na ya n'ezie.

Ọzọkwa, uru nke Augmentin ka a na-atụle ga-ekwe omume iji ya mee ụmụ nwanyị dị ime, ọkachasị na ọkara nke II na III. Ndị dọkịta na-ekwu na n'oge oge a maka ọgwụgwọ ọma ọ dị ezigbo mkpa ịlele nha usoro ọgwụgwọ ma soro ndụmọdụ niile.

Ọnụahịa Augmentin dị na ụlọ ahịa ọgwụ

Ọnụ ego nke Augmentin na ụdị mbadamba: usoro onunu ogwu 875 mg / 125 mg - 355-388 rubles. kwa ngwungwu pcs iri na anọ., onunu ogwu nke 500 mg / 125 mg - 305-421 rubles. kwa ngwungwu nke pcs iri na anọ., onunu ogwu nke 250 mg / 125 mg - 250-266 rubles. Kwa mkpọ 20 pcs.

Nwere ike ịzụta ntụ ntụ maka nkwadebe nkwusioru nke ọnụ na iji ọgwụ nke 125 mg / 31.25 mg na 5 ml ihe dị ka 134-158 rubles, usoro nke 200 mg / 28.5 mg na 5 ml maka 147-162 rubles, na usoro nke 400 mg / 57 mg na 5 ml - maka 250–276 rubles.

Ntụ ntụ maka ịkwadebe ihe ngwọta maka nchịkwa intraven adịghị ugbu a.