Alfa lipoic acid

Ngwurugwu ndu a na - aru ​​oru - alfa lipoic acid, nke di n’ime ogwu ufodu, nwere otutu otutu ihe eji egosi. Ngwakọta a, nke a maara dị ka vitamin N ma ọ bụ thioctic acid, na-egosipụta ọrụ antioxidant, na-eme ka ọrụ insulin dịkwuo elu, ma na-eme ka mmepụta ume dịkwuo ike. Lipoic acid dị na mbadamba ụrọ na-enye aka ịme ka usoro nke arụ ọrụ ahụ dị ike ọ bụghị naanị ndị ọrịa, kamakwa ndị hụrụ egwuregwu n'anya.

Gini bu alpha lipoic acid?

A na - enweta Thioctic acid na 1950 site na imeju bovine. Enwere ike ịchọta ya na mkpụrụ ndụ niile nke akụkụ ahụ dị ndụ, ebe ọ na - etinye aka na usoro nke mmepụta ume. Lipoic acid bụ otu n'ime ihe ndị dị mkpa maka nhazi nke glucose. Na mgbakwunye, a na-ahụta ihe owuwu a dị ka ihe antioxidant - ọ na - enwe ike iwepụ radicals na - enweghị usoro guzobere n'oge usoro oxidation ma kwalite mmetụta nke vitamin. Enweghị ALA na-emetụta ọrụ nke akụkụ ahụ dum.

Lipoic acid (ALA) na-ezo aka na ọdụdụ nwere abụba nwere. Ọ na-egosiputa Njirimara nke vitamin na ọgwụ. N’ụdị dị ọcha, akụrụngwa a bụ ntụ ntụ na-acha odo odo nke nwere ezigbo isi na uto ilu. A na-a acidụ acid nke ukwuu na abụba, a alcoụrụma, na mmiri nke ọma, nke na-egbuze sodium nnu nke vitamin N. A na-eji ogige a maka nkwadebe nri na ọgwụ.

Omume ọgwụ

A na-emepụta Lipoic acid site na sel ọ bụla na ahụ, mana ego a ezughi maka ịrụ ọrụ sistemụ arụmọrụ nkịtị. Onye ahụ na-enweta oke nke ihe ya site na ngwaahịa ma ọ bụ ọgwụ. Ahụ mmadụ na-agbanwe ntụpọ Lipoic ka ọ bụrụ ọgwụ dihydrolipoic dị irè karị. ALA na-arụ ọtụtụ ọrụ dị mkpa:

• Na-ebelata ngosipụta nke mkpụrụ ndụ ihe nketa na-ahụ maka mmepe nke mbufụt.
• Ọ na - egbochi mmetụta nke radicals n'efu. Ihe a bu acid bu ihe ogwu na –eme ka akwara aru ghara idi ihe oma nke ihe ekwuru. Annwetakwu ego nke ogige bioactive na-enyere aka ịkwụsị mmepe ma ọ bụ gbochie etuto ahụ, ọrịa shuga, atherosclerosis na ọrịa ndị ọzọ siri ike.
• Ọ na - eme ka mkpụrụ ndụ ahụ nwee insulin.
• Ọ na-enyere aka ịlụso oke ibu ọgụ.
• Na-ekere òkè na mmeghachi omume biochemical nke mitochondrial iji wepụta ume sitere na nri mmebi.
• Ọ na - eme ka ọrụ imeju mebisichara emebi.
• Na-achịkwa ọrụ nke obi, arịa ọbara.
• Na-eweghachi ọgwụ antioxidants nke otu ndị ọzọ - vitamin C, E, glutathione.
• Ọ na-emezigharị otu n'ime coenzymes NAD na coenzyme Q10 kacha mkpa.
• Na-ahụ maka ọrụ nkwụchi-ọgwụ nke T-lymphocytes.
• Ọ na –emekọ ya na vitamin nke otu B nri na - abanye n'ime ahụ na ume.
• Lowers ọbara shuga.
• Ọ na - ejikọ ma na - akwalite mwepụ nke ihe ndị na - egbu egbu yana ọla dị arọ - arsenic, mercury, lead.
• ALA bụ ihe nrụpụta nke ụfọdụ enzymes mitochondrial na-amalite usoro nke nrụpụta ike.

Ihe ngosi maka ojiji

N'ụfọdụ, maka ịrụ ọrụ nke ọma, ahụta ihe a na-enweta na ngwaahịa yana mkpụrụ ndụ mepụtara. Ojiji nke lipoic acid na mbadamba, capsules ma ọ bụ ampoules ga-enyere ndị mmadụ aka ịgbake ngwa ngwa, mgbatị siri ike ma ọ bụ ọrịa na-eme ka ike gwụ ha. Ọgwụ, ọdịnaya nke ALA, nwere mmetụta dị mgbagwoju anya. Dabere na ọtụtụ ndị ọkachamara, a na-eji ha eme ihe n'egwuregwu, ọgwụ na ịlụso oke ibu.

Akwukwo nleba anya nke ogwu banyere nha nke ALA:

• neuropathy
• arụ ọrụ ụbụrụ;
• ịba ọcha n'anya
• ọrịa shuga mellitus
• a .ụrụma
• cholecystitis
• ọria aru
• nsi iji ọgwụ, nsí, ọla dị arọ,
• cirrhosis nke imeju
• atherosclerosis nke akwara ozi.

N'ihi mmezu nke ike ọrụ, enwere ike iji ọgwụ ogwu nwere thioctic acid luso oke ibu ọgụ. Nri nke ihe ahu nwere aru nke ifelata na aru na egwuregwu. Ọ bụghị nanị na a na-eme ka abụba dị ọkụ, kama ọ na-emekwa ka umeji ahụ dịkwuo ike. Nọgide na-enwe ihe oriri na-edozi ahụ ga-enyere gị aka iru ngwa ngwa ihe mgbaru ọsọ nke ifelata ma na-adị mma n'ọdịnihu. A na-eji ntụpọ Lipoic mee ihe na nrụpụta ahụ maka ngwa ngwa gbakee na abụba ọkụ. A na-atụ aro ka ewere ya na L-carnitine.

Ntụziaka maka iji thioctic acid

Etu esi ewere lipoic acid maka ọgwụgwọ na mgbochi? Ogologo oge ọgwụgwọ na vitamin N bụ ọnwa 1. Ọ bụrụ na ọgwụ bụ maka ọnụ, mgbe ahụ ịkwesịrị ị drinkụ ya ozugbo ị rie nri. Maka usoro ọgwụgwọ, a na-enye ọgwụ ahụ na ọnụọgụ 100-200 mg kwa ụbọchị. Iji hụ na mgbochi nke ọrịa metabolic na mmepe nke ọrịa n'afọ niile, a na-ebelata ọgwụ ọgwụ ahụ ruo 50-150 mg. N'ọnọdụ dị njọ, a na-enye ndị ọrịa ọgwụ dị elu - 600-1200 mg kwa ụbọchị. Acid a bu ihe ojoo n’enweghi nsogbu, ma mgbe ufodi, o nwere ike ibute ihe ndi ahu na aru.

Ntuziaka maka ifelata

Lipoic acid tinyere nri edoziziri, yana mmega ahụ na-eme ka metabolism dịkwuo elu ma na - enyere aka ibute ndị oke ibu. Iji wepu oke ibu, uzo ogwu a di elu karie onodu aru ike mgbe ichochara dọkịta. A na-ewere ọgwụ mbụ n’oge nri ụtụtụ, nke abụọ mgbe ọzụzụ, yana nke atọ jiri nri abalị.

Lipoic Acid maka oria shuga

Maka ọgwụgwọ nke ọrịa shuga, enwere ike ịkọwa mbadamba ihe a nwere ma ọ bụ ọgwụ ịgba ọgwụ mgbochi. A naghị atụ aro ịralụ ọgwụ ahụ mgbe ị risịrị nri, ọ ka mma ị itụ ya na afọ na-adịghị efu. Usoro ị drugụ ọgwụ maka ọrịa shuga bụ 600-1200 mg kwa ụbọchị. A na-anabata ALA nke ọma, mana mgbe ụfọdụ mgbe ị na-ewere nnukwu ego nke ihe na-arụ ọrụ, ihe ọkụ, itching, afọ ọsịsa ma ọ bụ ihe mgbu na mpaghara epigastric. Usoro ọgwụgwọ bụ izu anọ, n'ọnọdụ ụfọdụ, site na mkpebi nke dọkịta, enwere ike ịgbatị ya.

Jiri n’oge ime na inye nwa ara

Ihe akụrụngwa a na-arụ ọrụ nke ihe ndị dị ndụ nwere nke nchekwa dị mma, mana amachibidoro iji ụmụ nwanyị dị ime na ndị nne na-enye nwa ara, n'ihi na ekwenyebeghị ọgwụ ya na nwa ebu n’afọ. N’ọnọdụ ndị siri ike, a pụrụ inye ndị ọgwụ na-atụ anya ịmụ nwa ọgwụ ma ọ bụrụ na uru ọ ga-abara ya ga-akarị ihe ọjọọ a ga-eme nwa ahụ. Ekwesịrị ịhapụ inye nwa amụrụ ọhụrụ nwa n'oge ọgwụgwọ.

Alfa Lipoic Acid

A na-ahụta ogige ALA (alfa ma ọ bụ thioctici acid) n'ọtụtụ ọgwụ na nri nri nke ogo na ọnụahịa dị iche iche. Ha dị n'ụdị mbadamba ụrọ, chasules, tinye uche na ampoules maka nchịkwa intraven. Ọgwụ nwere ALA:

• Ugbo ala,
• Lipamide
• Lipothioxone
• Mkpụrụ egbugbere ọnụ Neuro
• Oktolipen
• Tiogamma
• Thioctacid
• Tiolepta
• Thiolipone.

Nlekọta nwere thioctic acid:

• NCP Antioxidant,
• ALK sitere na ndị agha,
• Gastrofilin gbakwunyere
• Microhydrin
• Mkpụrụedemede mkpụrụedemede,
• Ọrịa shuga na ndị ọzọ.

Mkparịta ụka ọgwụ ọjọọ

A na - eme ka ọgwụgwọ ọgwụgwọ nke compound na - adịwanye mma mgbe ejiri ya na vitamin B, L-carnitine mee ihe. N'okpuru mmetụta acid, insulin nwere ọgwụ ndị na-ebelata shuga na-arụ ọrụ karị. Agaghị agwakọta inje nke ihe ahụ na ngwọta nke glucose, fructose na shuga ndị ọzọ. ALA na-ebelata ịdị irè nke ngwaahịa nwere ion drọd: iron, calcium, magnesium. Ọ bụrụ na egboro ọgwụ abụọ a ọgwụ, aga-ahụ oge dị ka elekere anọ ga-anọ n ’oriri ha.

Lipoic acid na mmanya

Of ofụbiga mmanya na-egbu egbu na-ebelata ịdị irè nke ọgwụgwọ. Mmanya ethyl nwere ike ịka ahụike nke onye ọrịa ahụ ike. N'oge ọgwụgwọ, a ga-ahapụ mmanya na-aba n'anya kpamkpam, ndị mmadụ nwere ọgwụ riri ahụ chọrọ enyemaka site n'aka ọkachamara.

Nsonaazụ

A na-ele ALA anya dị ka ihe na - adịghị ize ndụ mgbe a hụrụ usoro onyonyo egosipụtara maka ọgwụgwọ. Ọrịa ndị a na-ebute na ọgwụ adịghị esikebe, gosipụtara ihe mgbaàmà ndị a:

• ehighi ura
• ụba nchegbu
• ike ọgwụgwụ
• ụrịa afọ
• ihe odide
• nācha ọbara-ọbara,
• ọgbụgbọ
• mgbu n’afọ
• nsogbu anaphylactic,
• na -adalata shuga dị elu,
• iku ume ike.

Ihe ngbanwe

Ọgwụ nke nwere ihe na - arụ ọrụ ihe egwu ekwesịghị ụmụ nwanyị dị ime na ndị na - actụ nwa, kwesịrị inweta ụmụaka ndị na-erubeghị afọ isii, n'ihi na enweghị ozi zuru oke gbasara enweghị mmerụ ahụ ha. Nwere ike iji ọgwụ dị otu a naanị mgbe ị nyochachara dọkịta gị, ọkachasị ndị nwere ọrịa na - esote:

• ndị ọrịa na-arịa ọrịa shuga
• ndị nwere vitamin B,
• ndị ọrịa nwere pathologies nke usoro homonụ na ọrịa oncological.

N'etiti ọtụtụ ụzọ isi gwọọ ma mee ka ahụ sie ike, ọgwụ na-ahụ maka ọgwụ ndị a na-esote nwere mmetụta ALA yiri nke a ga-ewere ya mgbe ya na dọkịta nyochachara.

• ọgwụ na ihe ọ juiceụ juiceụ aloe,
• Ozu
• Apilak
• Spirulina algae na mbadamba, ntụ ntụ, tapawa.

Ọgwụ nwere ALA nwere ike zụta ya n'ụlọ ahịa ọgwụ dị n'obodo ma ọ bụ, site na katalọgụ, zụrụ n'ụlọ ahịa n'ịntanetị. Ọnụ ahịa ọgwụ nwere Lipoic acid dị ka ndị a:

Usoro nke ime ihe

Alfa lipoic acid na - agbanwe glucose ma nwee ume ma na - awakpo radicals, nke bụ ihe na - emerụ ahụ.

ALA na-abawanye metabolism, na-ebelata ihe ojoo nke oxidation ma weghachite ọkwa nke vitamin n’ahụ, karịsịa vitamin C na E.

Na mgbakwunye, alfa lipoic acid na-arụ ọrụ dị ka synergist na vitamin B, nke dị mkpa iji mee ka macronutrients niile nweta nri ka ọ bụrụ ume.

Ọ bụ ezie na alfa lipoic acid bụ abụba abụba, ọ na-agbanyekwa mmiri. Imirikiti mmeju na-agbanye mmiri naanị na abụba ma ọ bụ mmiri, mana ọbụghị n'ime abụọ n'otu oge. Omume a na-eme ka alfa lipoic acid pụrụ iche ma na-adịkwa mma n'ọtụtụ akụkụ nke ahụ, nke na-emekwa ka ụfọdụ na-akpọ ya "antioxidant ụwa."

Mgbe a na -ekwu ya n’onu, a na-etinye alfa lipoic acid n’ime eriri afọ. N'adịghị ka nri ndị ọzọ nwere abụba, ọ chọghị ka nri jupụta acid na abụba. N'ihi ya, ịnwere ike iburu ALA n'oge ibu ọnụ ma ọ bụ afọ efu.

Ike antioxidant

Imirikiti akụrụngwa ọgwụgwọ nke alfa lipoic acid sitere na ọnọdụ antioxidant ya. Antioxidants bụ ụmụ irighiri ihe na - egbochi ihe ndị na - akpata ihe ojoo na - ebute nsogbu oxidative ma na - emebi mkpụrụ ndụ. N’oge ịchụ ehi, a na-ekewa O2 n’ime atom oxygen abụọ, nke ọ bụla nwere otu elektrọn. N'ihi na elektrọn na-ahọrọ ịnọ na abụọ, '' free radicals '' 'otu elektrọn - na-achọ ma họrọ elektrọn ndị ọzọ, si otú ahụ na-emebi mkpụrụ ndụ. Ọ bụghị naanị na alfa lipoic acid na-echebe megide radicals, mana ọ na - enyere aka ịbawanye arụmọrụ nke antioxidants ndị ọzọ dị ka vitamin C na vitamin E.

Mgbasa homonụ

N'ihu akpịrị bụ akwara gland, nke bụ akụkụ dị mkpa nke usoro endocrine. Otu n'ime ọrụ kachasị mkpa bụ mmepụta nke homonụ nke na-achịkwa uto, uto na metabolism. Mgbe ahụ ike thyroid nọ n'ihe ize ndụ, homonụ na-apụ nke kwesịrị. Nnyocha e mere na 2016 gosipụtara na alfa-lipoic acid mgbe a na-ewere ya na quercetin na resveratrol na-enyere aka iwelie ọkwa nke homonụ thyroid na oke ibu kpatara site na ahaghị nkwụghachi nke homonụ.

Na-akwado glucose Ọbara

Ọbara shuga dị n'ọbara, ma ọ bụ shuga n'ọbara, bụ n'ihi ike ahụ mmadụ ịnọgide na-enwe ọ̀tụ̀tụ̀ insulin nkịtị, mmiri ọgwụ na-enyere glucose aka n’ahụ gị. Enweghị insulin, glucose na-ewuli elu ma nwee ike ibute ọtụtụ nsogbu ahụike. Ọmụmụ ihe ọmụmụ 2017 nyochara nsonaazụ nke alfa lipoic acid na glucose ọbara, achọpụtara na ọ na-enyere aka ịnọgide na-enwe glucose ọbara nkịtị na mmetụta insulin, nke na-egosi na ihe ndị ALA na-agabiga bụ na ọ bụ ọgwụ antioxidant. .

Mmụba uche insulin

Na ndị na-arịa ọrịa shuga, n'ihi ọkwa shuga dị elu ọbara, mmebi akwara siri ike na - amalite - neuropathy mamịrị. ALA na-abawanye ọgụgụ insulin ma belata akara nke ọnọdụ a site na imezi microcirculation. Dika otutu ihe omumu, alfa lipoic acid belata ihe ngosi nke akwara ndi mebiri emebi (ihe ngbu, ntimkpu nke aka na ukwu, mmasi).

Isi uru alfa-lipoic acid dị na ndị ọrịa mamịrị bụ mbelata ihe egwu na-emetụta ọrịa neuropathic nke na-emetụta obi, ebe ihe dị ka pasent 25 nke ndị nwere ọrịa shuga na-etolite ọrịa obi. Ejiri ya na mgbanwe mgbanwe mkpụrụobi na-ebelata ma ejikọtara ya na ọghọm ọnwụ nke ndị na-arịa ọrịa shuga. Nnyocha e mere na-egosi na ịgbakwunye 600 mg kwa ụbọchị nke ALA maka izu atọ na-ebelata ihe mgbaàmà nke ọrịa neuropathy mamịrị.

Na-enyere aka ịkwalite glutathione

A na-ahụta Glutathione dị ka “antioxidant kachasị” n'ihi na ọ dị oke mkpa maka mgbochi, ahụike cellular na mgbochi ọrịa. Nnyocha e mere egosiwo na 300-10000 mg nke alpha lipoic acid na-enyere aka ịbawanye ike nke glutathione iji meziwanye mmeghachi nke ahụ.

Mgbakwunye ALA nwere mmetụta dị mma n'ahụ ndị ọrịa nwere syndromes immunodeficiency syndodes, na-eweghachi ọkwa glutathione ọbara ma melite nzaghachi nke lymphocytes na Tito cell mitogens.

Obi ike

Ọkpụkpụ ọbara nwere otu ahịrị sel nke ana - akpọ endothelium. Mgbe mkpụrụ ndụ endothelial dị mma, ha na-enyere izu ahụ arịa ọbara. Enwere ike mejupụta akpụkpọ ahụ endothelial n'ihi ọrịa, nke na-eduga n'ịdị njọ na ahụ ike vaskụla.

Na afọ, nrụgide oxidative na-emetụta ahụike nke sistem obi. Nrụgide na-adịghị ala ala na-emebi akwara endothelial nke akwara ndị ahụ ma na-emetụta ọfụma ọbara. Ọ bụ ezie na ọrụ obi na-akawanye njọ nwere ike ibute nnukwu nsogbu ahụike, ọgwụ antioxidants na-enyere aka iwusi ike obi ike. Alfa lipoic acid na-egbochi ọnwụ mkpụrụ ndụ ma na-eme ka ọrụ obi rụọ ọrụ.

Neuroprotection

Ọ bụghị nanị na Alfa lipoic acid na-akwalite mmelite nke neurons, kamakwa ọ na-enyere aka ịlụ ọgụ ọgbụgba neurodegenerative. Nsonaazụ nke ọmụmụ nke oke nwere ọrịa ọnya gosipụtara na ALA bara uru maka ọgwụgwọ nke ọrịa ischemic n'ihi akwara na-eweghachi ya na iweghachi. N’ọmụmụ ihe ọzọ, ALA belatara ọnwụ site na 78% rue 26%, n’ime awa iri abụọ na anọ mmalite nke ọrịa strok.

Oxidative nrụgide nwere ike imebi irighiri akwara ndị dị n’anya ma kpatara nsogbu ọhụụ.Ejirila alpha lipoic acid mee ihe nke ọma iji chịkwaa ihe mgbaàmà nke nsogbu anya, gụnyere ọnwụ nke ọhụhụ, nbibi anụ ahụ, mbibi azụ, cataracts, glaucoma, na ọrịa Wilson.

Nsonaazụ nyocha gosipụtara na iji ọgwụ alpha-lipoic acid mee ihe ogologo oge nwere mmetụta bara uru na mmepe nke retinopathy. Ka ndị mmadụ na-eto, ọhụhụ ha na-abawanye, yabụ, ọ dị mkpa ịgbaso nri nwere nri na-edozi ahụ, ogologo oge tupu ịka nká, iji gbochie nhụjuanya anya ma ọ bụ ọhụhụ ụzọ n’oge.

Na - egbochi mọzụlụ site na nrụgide oxidative

Mmega ahụ bụ otu n’ime ụzọ kachasị mma iji nweta oke ibu, mgbasa ọbara n’ọbara ma mee ka ọkwa ume dịkwuo elu. Mmega ahụ siri ike nwere ike ime ka mmebi oxidative kwụsị ngwa ngwa, nke na-emetụta akwara anụ ahụ na mkpụrụ ndụ.

Nchegbu Oxidative so akpata mgbu ị na-enwe mgbe ị nwesịrị ọzụzụ ike. Ngwakọta antioxidant dị ka alpha lipoic acid nwere ike inyere aka belata mmetụta a. Ihe mgbakwunye Alpo lipoic acid na-akwado nchekwa nke antioxidant dị n'ime ma belata peroxidation lipid.

Onyinye n’enye Ochie Agam

Na afọ, nrụgide oxidative nwere mmetụta na-adịghị mma na mkpụrụ ndụ ma na-akpata ịka nká. Mmụta amụọla ọgwụ antioxidant nke alfa lipoic acid. Fọdụ na-egosi na ALA na-ebelata nrụgide oxidative na sel akwara. Ọmụmụ ihe ndị ọzọ egosipụtara na ALA bara uru iji gbochie ụkọ ụba ụbụrụ na cobex nke ụbụrụ.

Na-akwado Ike Ahụike

Iri nri haziri, nri ngwa ngwa, na nri nri ndị ọzọ na-adịghị mma na-ebute oke ibu. Atụmatụ ịnwebelata ndụ dị mma, ahụike dị oke mkpa na-agụnye mmega ahụ oge niile na nri na-edozi ahụ. Agbanyeghị, nri ndị dị ka alfa lipoic acid nwere ike ịkwalite mmetụta nke ibi ndụ dị mma. Ọmụmụ ihe ahụ gosiri na ndị ọrịa butere ALA nwere oke oke ibu ma e jiri ya tụnyere ndị placebo.

Uru ndị ọzọ nke alfa lipoic acid

• Ọ na-ebelata ihe egwu dị n’oge ime ma na-eme ka ahụike ahụike nke nne ma nwa ebu n’afọ.
• Na-ebelata nsonaazụ ọgwụ ọgwụ antipsychotic.
• Na-abawanye mkpokọta spam, ntinye uche, na motility.
• Na-egbochi imebi ọkpụkpụ na ụmụ nwanyị nwere ọrịa osteopenia na mfu ọkpụkpụ na ọnọdụ mbufụt.
• Ọ na-abawanye ogologo ndụ ma na-alụ ọgụ ngụgụ na ọrịa ara ure.