Glibenclamide: ntuziaka maka ojiji nke hypoglycemic agent

Glibenclamide bụ ọgwụ ọgwụ hypoglycemic nke metụtara n'ụdị sulfonylureas. Usoro nke ihe glibenclamide gụnyere mkpali nke nzuzo insulin β mkpụrụ ndụ n'ime pancreassite na ịbawanye na ịhapụ insulin. Dika odi, oru oma ka egosiputara na uzo ozo nke imeputa insulin. Nke a na - eme ka oghere anụ ahụ dị n ’ọrụ insulin yana njikọ ya na mkpụrụ ndụ ndị chọrọ. Na mgbakwunye, a na-amata glibenclamide site na nsonaazụ egbugbere ọnụ yana mbelata nke akụrụngwa nke thrombogenic. ọbara.

N'ime ahụ, ịmara ngwa ngwa na iwere ihe ahụ kpamkpam site na nri diges. Nkwukọrịta na protein plasma kwekọrọ na ihe dịka 95%. Metabolism a na-eburu ọgwụ ahụ na imeju, na-ebute nguzobe anaghị arụ ọrụ metabolites. Mgbaputa emejuputara tumadi na nchikota mmamiri na akuku - bile, n'uzo nke metabolites.

Ihe ngbanwe

A naghị akwado ọgwụ a maka iji ya:

• hypersensitivityka Glibenclamide ma obu sulfonamides na thiazide diuretics,
• preccatous ọrịa shuga
• ketoacidosis,
• oke oku
• mmerụ ahụ na itinye aka n'ịwa ahụ,
• eriri afọ na paresis nke afọ,
• dị iche iche ụdị nke malabsorption nri,
• mmepe hypoglycemia,
• ebe a na-enye nwa ara, nke di ime
• ọrịa shugaDị 1 na ndị ọzọ.

Nsonaazụ

N'ime ọgwụgwọ Glibenclamide, mmepe nke mgbaàmà achọghị ya na-emetụta ọrụ nke endocrine, digestive, ụjọ, oke na usoro hematopoietic ga-ekwe omume. Yabụ, ọ ga - aputa: hypoglycemiadịgasị iche iche ogo ogo ọgbụgbọ, afọ ọsịsaọrụ imeju na-arụ ọrụ, cholestasis, isi ọwụwaike na ume anya ntughari.

Nkpughe nke mmeghachi omume nfụkasị ahụ na ụdị anụ ahụ n'ụdị: ọnya ọnya, itching, photoensitization na mgbaama ndị ọzọ.

Ntụziaka maka iji Glibenclamide (Usoro na usoro onunu ogwu)

Ntuziaka maka iji Glibenclamide na-akọ na setịpụrụ ọgwụ ọgwụ ahụ n'otu n'otu ma dabere afọ, ogo nke ọrịa ahụ na ọkwa glycemia. Ana mbadamba mbadamba ndị ahụ, na afo efu ma ọ bụ awa 2 mgbe ị risịrị.

Edebere nkezi kwa ụbọchị na ogo nke 2.5-15 mg, yana njikwa ugboro ugboro 1-3 ugboro n'ụbọchị.

A na-ejikarị usoro ọgwụ kwa ụbọchị karịa 15 mg, na-enweghị mmụba dị ukwuu na mmetụta hypoglycemic. A na-enye ndị ọrịa ogo okenye ọgwụ ọgwụ kwa ụbọchị nke 1 mg na mmalite ọgwụgwọ. A ga-enwerịrị ntụgharị niile sitere na otu ọgwụ gaa na ọgwụ ọzọ, iji ọgwụ eme ihe na ihe ndị ọzọ, n'okpuru nlekọta nke ọkachamara.

Dodoụbiga ya ókè

Ọ bụrụ na ị doụbiga mmanya ókè, ọ ga-ekwe omume ịmalite ịmị mmadụ hypoglycemia, nke agụụ ga na-agụ ya, adịghị ike, nchebara echiche, isi ọwụwa, anya ntughari, ọsụsọ, nkuchi obiolu ọma jijiji ụbụrụ ụbụrụnkwuputa okwu na ọhụụ na ihe ndị ọzọ.

Ọgwụgwọ gụnyere shuga dị ngwa ngwa, mmiri mkpụrụ osisi, tii dị ụtọ, sirop ọka, mmanụ a cornụ - n'ọnọdụ dị nro.

Ọnọdụ ndị siri ike chọrọ ihe ngwọtaglucose 50% infusion na-aga n'ihu na usoro akwara Dextrose 5-10%, mmeghe Glucagon intramuscularly Diazoxide n'ime. Na mgbakwunye, ịkwesịrị ijikwa ọkwa nke glycemia, chọpụta pH, creatinine, urea nitrogen, electrolytes.

Mmekorita

Njikọ ya na systemic antifungal ọgwụ, fluoroquinolones, tetracyclines, chloramphenicol, H2-blockers, beta-blockers, ACE inhibitors na MAO,clofibrate, bezafibrate, probenecid, Paracetamol, ethionamide, anabolic steroids, pentoxifylline, allopurinol, cyclophosphamide, Reserpine, sulfonamide na Insulin nwee ike ịba hypoglycemia.

Jiri ya mee ihe barbiturates, phenothiazines, diazoxide, glucocorticoid na homonụ thyroid, estrogens, gestagens, glucagons, ọgwụ adrenomimetic, Ngwakọta lithium sitere na nicotinic acid na saluretics nwere ike ibelata mmetụta hypoglycemic.

N'aka nke nwere ike ikwesi mmamịrị mmata, dịka ọmụmaatụ: kalsium chloride, ammonium chloridennukwu doses acid nke ascorbic nwere ike ịkwalite mmetụta nke ọgwụ ahụ. Ihe jikọrọ ya na Rifampicin mee ngwangwa inactivation ma belata arụmọrụ ya.

Ntụziaka pụrụ iche

A na-atụ aro iji nlezianya na-agwọ ndị ọrịa na-arịa ọrịa imeju na akụrụ, ya na ọnọdụ febrile, na pathological arụ ọrụ nke adrenal gland ma ọ bụ thyroid gland, na-egbu egbu ahoụrụma.

Maka usoro ọgwụgwọ zuru oke, iji nlezianya na-ele ọkwa nke glucose dị n'ọbara na mgbatị glucose dị mkpa.

Ọ bụrụ na hypoglycemia na-etolite n'ime ndị ọrịa na mmụọ, mgbe ahụ, a na-eji ọnụ nye shuga ma ọ bụ glucose. N'ihe banyere ịmara mmụọ, a na-a gluụ glucose ọbara, glucagon - intramuscularly, subcutaneously ma ọ bụ intravenously.

Mgbe eweghachiri mmụọ, a na-enye onye ọrịa ahụ nri nwere carbohydrates ozugbo iji zere hypoglycemia ugboro ugboro.

Ngwakọta na ịhapụ ụdị

Na taabụ 1. ọgwụ antidiabetic nwere 1.75 mg, 3.5 mg ma ọ bụ 5 mg nke ihe ndị na-arụ ọrụ, nke bụ glibenclamide.

Ọzọkwa na ọgwụ dị:

• Povidone
• Lactose Monohydrate
• Iri ite
• Stereta magnesium
• Ponceau 4R.

Mbadamba nkume ndị ahụ dị gburugburu, na-acha odo odo na agba, nwere ike ịgbawa. Ọgwụ ahụ dị n’ karama nwere iko mbadamba 120, agbakwunyere akwụkwọ ntuziaka onye ọrụ.

Ngwongwo na-agwọ ọrịa

Ọ dị mma ịmara na aha ahịa ọgwụ dabara na aha nke mpaghara ahụrụ ọrụ. Ọgwụ nwere mmetụta hypoglycemic ma ndị mmadụ n'otu n'otu na-arịa ụdị ọrịa shuga mellitus nke 2, yana ndị ahụ gbasiri ike. Usoro nke usoro a na-esite na insulin insulin na-arịwanye elu site na mkpụrụ ndụ nke β-anụ nke pancreas n'ihi mkpali ọrụ ya. Mmetụta dị otú a na-adabere, nke mbụ, na ọkwa nke glucose na ọkara nke dị gburugburu mkpụrụ ndụ β.

Mgbe ị takingụ ọgwụ ahụ, ngwa ahụ nọ n'ọrụ na-agbakarị ọsọ ọsọ, ọ fọkwara nke ọma. Site na nri, enweghi mbelata di uto na ntinye nke glibenclamide. Ihe ngosi nke nkwurita okwu na protein ndi plasma bu 98%. A na-ahụta ihe kachasị ukwuu n'ime otu ihe dị na serum mgbe elekere 2.5 gachara. Edere mbelata nke ịkpa ike glibenclamide mgbe awa 8-10 gachara ma dabere n ’ọgwụ onye ọrịa ahụ patientụrụ. Iwepu ọkara ndụ bụ na elekere asaa.

Mgbanwe Metabolic nke glibenclamide na-adị na sel imeju, a na-emepụta metabolites, nke ihe fọrọ nke nta ka ọ bụrụ na-adịghị etinye aka na nsụda shuga nke ihe na-arụ ọrụ. A na-eji mmamịrị mepụta ọgwụ ndị sitere na metabolic, yana iji ya mee ihe na mkpụrụedemede ikpeazụ ka ọ mechara ihe dị ka awa iri anọ na ise gachara.

N'ime ndị nwere ọrụ imeju na-egbu egbu, edere oge glibenclamide na-egbu oge. N'ime ndị ọrịa na-ata ahụhụ site na akụrụ oke, excretion nke metabolites na-adịghị arụ ọrụ na mmamịrị na-abawanye ụgwọ.

Ntuziaka maka mbadamba mbadamba

Ọnụahịa: site na 56 ruo 131 rubles.

A na-ekpebi usoro ị drugsụ ọgwụ ọjọọ n'otu n'otu na-ewere afọ onye ọrịa, glycemia, yana ogo nke ọrịa ahụ. A na-atụ aro ịillsụ ọgwụ na afọ efu ma ọ bụ mgbe awa 2 gachara.

Dị ka ọ dị, nkezi kwa ụbọchị na-adị iche n'etiti 2.5 mg - 15 mg. Ugboro eji ọgwụ eji eme ihe bu 1-3 p. ogologo ụbọchị.

Isnabata usoro ọgwụgwọ kwa ụbọchị nke 15 mg na nke dị n’elu ka edepụtara nke ukwuu, nke a anaghị ewelie mmetụta hypoglycemic nke ọgwụ ahụ. A na-atụ aro ndị okenye ka ịmalite 1 mg kwa ụbọchị iji gwọọ ya.

Ntugharị site na ọgwụ ọgwụ antidiabet gaa na nke ọzọ ma ọ bụ mgbanwe na usoro ha ga-esi mee ya n'okpuru nlekọta dọkịta.

Nchedo nchekwa

Ekwesịrị ịgwọ ọrịa ọgwụgwọ n'oge nlele shuga na mmamịrị ọbara mgbe niile.

N'oge ọgwụgwọ, ị kwesịrị ịhapụ ị beụ ihe ọholicụ alcoụ na-aba n'anya, ebe ọ bụ na mmepe nke hypoglycemia, yana ngosipụta disulfiram, anaghị eso.

Mgbe ihe ịrịba ama nke hypoglycemia pụtara, ọ ga-adị mkpa iji kwụọ ụgwọ enweghi glucose site na nchịkwa ọnụ nke dextrose. N'ihe banyere ọnọdụ amaghị ihe, a na-edozi dextrose n'ime ọbara. Iji zere nlọghachi, ọ bara uru ịme nri na carbohydrates.

Mwepụta wepụtara ya na ihe mejupụtara

Sdị usoro onunu ogwu - mbadamba nkume: cylindrical dị larịị, nke nwere ahịrị na-acha ọcha, na-acha ọcha ma ọ bụ na-acha ọcha nke nwere agba ntụ ma ọ bụ ndò na-acha odo odo nke agba (pọọpu 10. N'ime blisters, na igbe kaadi nke 1, 2, 3 ma ọ bụ 5 ngwugwu, 20, 30 ma ọ bụ 50 ọ bụla. na ite jiri polymer ma ọ bụ iko gbara ọchịchịrị, na ngwungwu kaadi komputa 1 ike).

Ihe na-arụ ọrụ bụ glibenclamide, na mbadamba 1 - 5 mg.

Ngwa inye aka: lactose monohydrate (shuga mmiri ara ehi), magnesium stearate, povidone (ọgwụ polyvinylpyrrolidone dị ala), ọgwụ nduku.

Mlọ ọgwụ

Mgbe a na -ewere ya n'ọnụ, a na-etinye glibenclamide site na eriri afọ site na ihe dịka 48-84%. Oke ịta nke ihe a na-enweta 1-2 awa mgbe ochichi. Olu nke nkesa bụ 9-10 lita. Glibenclamide na-ejikọ protein protein plasma site na 95-99%. Ya bioavailability bụ 100%, yabụ enwere ike ị drugụ ọgwụ ahụ ozugbo nri.

Glibenclamide na-abanye na-emebi emebi site na mgbochi placental ma ọ na-agbachasị kpamkpam na imeju, na-akpụ metabolites abụọ na-adịghị arụ ọrụ, otu n'ime ya bụ ihe dị na bile, nke ọzọ na mmamịrị. Iwepu ọkara ndụ dị site na 3 ruo awa iri na isii nke iri na isii.

Ntụziaka maka iji Glibenclamide: usoro na usoro onunu ogwu

A na-ewere mbadamba nkume ndị ahụ 20-30 nkeji tupu ma ọ bụ awa 2 mgbe nri gasịrị.

Dọkịta depụtara ọgwụ ahụ n’otu n’otu, dabere n’arịa ọrịa shuga, afọ onye ọrịa na ọkwa nke akpịrị.

Ọkara a na-eme kwa ụbọchị bụ site na 2.5 ruo 15 mg, yana njikwa nchịkwa nke ugboro 1-3. N'ọnọdụ ndị a na-adịghị ahụkebe, a na-eji ọgwụ ahụ na ọnụọgụ karịa 15 mg kwa ụbọchị, nke a anaghị emetụta mmụba nke hypoglycemic mmetụta.

Ọgwụ izizi maka ndị ọrịa agadi bụ 1 mg kwa ụbọchị.

Ọgwụ mbụ nke ọgwụ mgbe ị na-agbanwe site na biguanides bụ 2.5 mg kwa ụbọchị.

Iji kwụọ ụgwọ maka mmebi nke carbohydrate metabolism mgbe akagbuchara biguanides, ịba ụba nke glibenclamide, ọ bụrụ na ọ dị mkpa, nwere ike iwelie 2.5 mg kwa ụbọchị 5-6. Ekwesịrị ịhazi ntughari na ọgwụgwọ ejikọtara ya na glibenclamide na biguanides na-enweghị ụgwọ dị otú ahụ n'ime izu 4-6.

Nsonaazụ

Ojiji nke ogwu ahu nwere ike ibute nsogbu ndi a:

• Site na usoro endocrine: hypoglycemia ruo coma (ọgwụ ziri ezi, ịgbaso usoro usoro nri na nri na-ebelata ohere nke mmepe ya),
• Site na sistemụ ụjọ: adịkarịghị - isi ọwụwa, isi ọwụwa, ike ọgwụgwụ, paresis, adịghị ike, nsogbu uche,
• Site na usoro digestive: mmetụta nke oke ụjọ na mpaghara epigastric, ọgbụgbọ, afọ ọsịsa, adịkarịghị - cholestasis, nsogbu imeju na-arụ ọrụ,
• Site na sistemụ hemopoietic: adịkarịghị - hematopoiesis, mmepe nke pancytopenia,
• Mmeghachi omume nfụkasị ahụ: itching, ọnya anụ ahụ,
• Mmeghachi omume udiri oria: na adighi ike - photoensitivity.

Ndị dọkịta na-atụle nyocha banyere glibenclamide

N'ime ọtụtụ ọgwụ edepụtara maka ịgwọ ọrịa shuga mellitus, dịka iwu, nke ụdị 2-1, ndị ọrịa chọpụtara adịghị ike nke Glibenclamide. Ekwesịrị m ijikọ ọgwụ ndị ọzọ.

Nnukwu echiche banyere ọgwụ. Onye nwere ọgwụ a, mmadụ enweghị ya. N’otu n’otu, ịkwesịrị idozi okwu a na dọkịta gị.

Nyocha ndị ọrịa Glibenclamide

N'oge na-adịbeghị anya, nna m dara ọrịa shuga nke 2. E nyere ya ụlọ ọgwụ n'ihi oke mbibi. E nwere ọbara shuga 14. Onye na-ahụ maka ọgwụ endocrinologist nyere iwu banyere metformin na glibenclamide (echetaghị m aha azụmahịa nke ọgwụ ndị ahụ). Nna m na-a drugsụ ọgwụ ike otu ọnwa ugboro atọ n'ụbọchị. Ebe otu izu mgbe m malitere ị medicineụ ọgwụ, amalitere m mkpesa nke ọgbụgbọ mgbe niile, mana, dị ka ya si kwuo, nke a abụghị ihe dị mkpa ma e jiri ya tụnyere eziokwu ahụ na ọgwụ ahụ na-ejikwa ọkwa glucose na 6-7 (anyị na-eji glucometer oge niile), ya mere nna m. na-enwe afọ ojuju.

Ọrịa shuga m dị afọ ise. Na mbu ha jiri metformin gwọ ha, mana ọ naghị arụ ọrụ nke ọma - enweghị mmetụta dị n'akụkụ ọ bụla, mana enweghị ụdị ọganiihu ọ bụla na ịdị ọcha shuga. Ma nke a n'agbanyeghị eziokwu na m welitere dose ahụ ugboro abụọ. Afọ abụọ gara aga, a na-enye m ọgwụ glibenclamide, na-agbakwunye ya na metformin, ma kemgbe ahụ, ihe agbanweela. Achọpụtaghị nsonaazụ ọ bụla, mana ha na-eche na ọ dị mma yana shuga na-erughị 7.

N’oge na-adịbeghị anya, enwere m ọrịa a, ihe dịka afọ 3-4, chọpụtara na mberede na nyocha ahụike, echeghị m na m nwere ike ịrịa ọrịa shuga. Ugbu a abụ m onye nleta oge niile na obodo Essentuki yana usoro ọgwụgwọ. Mana m na-ewere Glibenclamide, n'agbanyeghị, a na-edenye m ọgwụ a ebe a n'obodo a, ha kwuru na ọ ka nke ọma ma ga-enyere m aka. Ana m a drugsụ ọgwụ ndị ọzọ na-eme ka shuga dị n'ọrịa na-enweghị ike. Na mbụ, enwere m mmetụta n'akụkụ n'ụdị ọgbụgbọ na afọ ọsịsa, mana mgbe ejiri ogologo oge were ha, ha malitere ịpụ n'anya, o doro anya, ọgwụ riri ahụ na-aga n'ihu. Mana ihe kachasị mkpa bụ na a na-ebelata ọkwa shuga nke ukwuu mgbe ị na-a theụ ọgwụ ahụ, nke glucometer dere ya na ezigbo ahụ ike ụbọchị ahụ.

Anọwo m arịa ọrịa shuga kemgbe ihe karịrị afọ iri na ise. M nwara ọgwụ dị iche iche na-ebelata shuga, mana Glibenclamide ka bụ nke kachasi m mma. Nsonaazụ n'ụdị ọgbụgbọ na enweghị agụụ dị na izu mbụ, emesia ihe niile gazie. Ọ na - ebelata shuga nke ọma na ịba ụba ma na - enye gị ohere idobe ya nkịtị. Naanị nsogbu - ị ga-agbanye shuga ugboro ugboro. Ma mụ onwe m ọ bụrụla usoro a maara nke ọma.

Nkọwapụta dị mkpirikpi

Mkpụrụ ọgwụ na-ebelata glibenclamide na mmiri ọgwụ ya bụ nke ọgbọ abụọ nke usoro sulfonylurea. N'iburu ọgwụ ọgwụ "mbelata" nke ọgwụ a (yana ọrụ ụlọ ọgwụ ejirila ya na afọ 1969), ntụkwasị obi ya na ihe omuma ya nwere ike na-aga n'ihu. Ma ọ bụghị naanị ịnọ n’azụ ụlọ, kama ịbụ otu n’ime ọgwụgwọ ndị kachasị ewu ewu maka ụdị shuga nke 2. N'ime ụlọ nyocha na nyocha ụlọ ọgwụ, glibenclamide ka bụ ọkọlọtọ maka ịtụle arụmọrụ nke ọgwụ ọgwụ na arụ ọrụ ọhụụ na usoro ọgwụgwọ antidiabetic, ebe ha na-egosipụta akụrụngwa bara uru ọhụụ. Usoro nyocha nke ọrụ hypoglycemic nke glibenclamide, yana ọgwụ ndị ọzọ nke otu a, ka a nyochachara n'ụzọ zuru oke n'ụzọ nkịtị agbajikwa ụmụ irighiri ihe: ọgwụ ahụ na - egbochi mkpụrụ ndụ potassium nke pancreatic β-mkpụrụ ndụ, nke na - enye aka na ntinye aka nke mkpụrụ ndụ calcium na sel, nke na - eme ka mbibi nke granules nwere insulin na mwepu nke ikpeazụ n'ime ọbara na n ’ọnye ọnya. N'etiti usoro nile nke sulfonylurea, enyere glibenclamide ezigbo mmekọrịta maka ndị na-anabata ya na mkpụrụ ndụ and-mkpụrụ na ike hypoglycemic kachasị n'etiti ihe niile na usoro sulfonylurea. Hapụ insulin bukwuo ibu, ka ọgwụ a accepted nara.Ọgwụ ọgwụ niile dị na klaasị a nwere mmetụta akpọrọ extra-pancreatic, na-eme ka uru anụ ahụ dị nro karị na insulin na imeziwanye glucose site na adipose na akwara anụ ahụ.

Ọnọdụ a na - enye aka na itinyekwu glucose site na anụ ahụ (gụọ: belata glycemia).

Ya mere, glibenclamide, dika otutu akara si di, ka na-asọ mpi. Nke mbụ, ọ bụ arụmọrụ gosipụtara site na itinye n'ọrụ ogologo oge. Ọgwụ na - egbochi ihe oge na - egbu ọrịa shuga, gụnyere infarction myocardial na nsogbu microvascular. A na-ejikọta Glibenclamide nke ọma na ọgwụ ndị ọzọ, dịka ọmụmaatụ, metformin, ọ bụrụ na enwetaghị ụgwọ ụgwọ ọrịa, enwere ike ịnweta nsonaazụ dị mma site na ngwakọta nke metformin + glibenclamide + glitazone. A na-eji Glibenclamide mee ihe nke ọma na ndị ọrịa nwere “bouquet” nke ọrịa concomitant. Ma ihe di nkpa (na otutu ndi obodo anyi - nke kachasi mkpa), a na-enweta ogwu ahu site na echiche ndi mmadu. Ọ dị ọnụ ala karịa ọtụtụ ndị ọrụ "ibe" ya ọhụụ ugbu a n'ọgụ megide ọrịa shuga.

Mgbe ị na-ewere glibenclamide, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose n'ihi ohere nke hypoglycemic mmeghachi omume. Ọ bụrụ na hypoglycemia kpuchie “onye ọrịa nke takenụrụ ọgwụ ahụ, mgbe ahụ ọ dị mkpa ozugbo ịchọpụta na glucose na-abanye n'ahụ ya (n'ọnụ ma ọ bụ ntụtụ, dabere na ọnọdụ ọ maara). N'aka nke ọzọ, debe nri n'ụba carbohydrates ngwa ngwa n'oge niile.

Ọgwụ Farmacology

Ngwunye ọgwụ hypoglycemic nke na-ahụ maka ọnya, ihe dị na usoro nke usoro nke n'ọgbọ nke abụọ. Na-akpali mmiri ọgwụ insulin site na sel-nke pancreas, na-abawanye ntọhapụ nke insulin. Ọ na-abụkarị n'ọgba nke abụọ nke insulin na-agba. Ọ na - eme ka ọ bụrụ uru anụ ahụ dị na insulin na ogo nke ya jikọtara ya na mkpụrụ ndụ. Ọ nwere mmetụta hypolipPs, na -ebelata arịa nke thrombogenic nke ọbara.

Mkparịta ụka ọgwụ ọjọọ

Ọgwụ antimycotic nke systemic action, ethionamide, fluoroquinolones, MAO na ACE inhibitors, H2-blockers, NSAIDs, ọgwụ tetracycline, paracetamol, insulin, ọgwụ anabolic steroid, cyclophosphamide, β-adrenergic blockers, clofibrate, reserpilamin, proberpilin allopurinol, paracetamol, yana chloramphenicol nwere ike ịbawanye oke nke hypoglycemia.

COCs, barbiturates, glucagon, saluretics, nkwadebe dabere na salhi lithium, diazoxide, nicotinic acideri, phenothiazines, yana ọgwụ adrenomimetic belata mmetụta hypoglycemic nke glibenclamide.

Nke pụtara na acidify mmamịrị na-abawanye arụmọrụ nke ọgwụ.

Rifampicin na-akwalite inacering nke ihe na-arụ ọrụ ma belata mmetụta ọgwụgwọ ya.

Usoro onunu ogwu na nhazi

A na-ahọrọ dose ahụ n’otu n’otu. N'ime, nkeji 20-30 tupu iri nri, na-a plentyụ ọtụtụ mmiri mmiri. Ọgwụ nke mbụ bụ 2.5 mg / ụbọchị. Ọ bụrụ na ọ dị mkpa, a na-eji nwayọ ahụ were 2.5 mg kwa izu iji rite ụgwọ maka metabolism metabolism. Usoro mmezi kwa ụbọchị bụ 5-10 mg, ihe kachasị bụ 15 mg. Maka ndị ọrịa agadi, ọgwụ mbụ bụ 1 mg / ụbọchị. Oge nchịkwa dị ugboro 1-3 n'ụbọchị.

Mmegha nke otu nosological

Ọnụ ahịa ahịa ọgwụ na Moscow

Hapụ okwu gị

Nchọpụta Ozi Ugbu A, ‰

Aha ọgwụ dị mkpa yana ọgwụ ndị dị mkpa

Asambodo ndenye aha Glibenclamide

• LP-003742

• LP-000933

• FS-000940

• LS-002499

• P N014959 / 01-2003

• LSR-008753/09

• LS-000992

• LS-002056

• LS-001139

• P N002907 / 01

• P N001630 / 01-2002

• P N013959 / 01-2002

• P N012149 / 01-2000

• P N012093 / 01-2000

• P N011705 / 01-2000

• P N011400 / 01-1999

• S-8-242 N011172

• 010027

• 95/370/3

• 82/374/1

Ndị ọrụ gọọmenti webụsaịtị nke ụlọ ọrụ RLS ®. Nnukwu akwụkwọ nkà ihe ọmụma nke ọgwụ na ngwongwo nke ọgwụ ahịa ọgwụ nke Internetntanetị Russia. Ndepụta ọgwụ ọgwụ Rlsnet.ru na-enye ndị ọrụ ohere ịnweta ntuziaka, ọnụahịa na nkọwapụta ọgwụ, nri nri, ngwaọrụ ọgwụ, ngwaọrụ ọgwụ na ngwaahịa ndị ọzọ. Ntuziaka pharmacological gunyere ozi banyere ihe mejupụtara na ụdị ntọhapụ, ihe ndị a na-eme ọgwụ, na-egosi iji ya, contraindications, mmetụta ndị dị na ya, mmekọrịta nke ọgwụ, ụzọ iji ọgwụ, ụlọ ọrụ ọgwụ. Akwụkwọ ndekọ ọgwụ ahụ nwere ọnụ ahịa ọgwụ na ngwaahịa ọgwụ na Moscow na obodo ndị ọzọ Russia.

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Mgbe ị na-ehota ihe ọmụma dị na peeji nke www.rlsnet.ru, njikọta isi mmalite ozi a chọrọ.

Ọtụtụ ihe ndị ọzọ na-adọrọ mmasị

Ikike niile echekwabara.

Anaghị anabata iji ihe azụmaahịa.

Ezubere ozi a maka ndị ọrụ ahụike.

Mkparịta ụka ọgwụ ọjọọ

Ojiji nke sulfonamides na-eme ogologo oge, beta-blockers, allopurinol, ndị na-anabolic, cimetidine, cyclophosphamide, clofibrate, isobarin, monoamine oxidase inhibitors (MAOs), salicylates, tetracyclines, na chloramphenicol nwere ike ịkwalite mmetụta hypoglycemic nke ọgwụ.

Glibenclamide nwere ike belata ma nwekwaa nsogbu ịmalite hyperglycemia na ndị ọrịa n’otu oge na-ewere chlorpromazine, barbiturates, diazoxide, phenothiazines, phenytoin, acetazolamide, glucocorticoids, glucagon, ọgwụ ọmịiko, indomethacin, nicotinates ọgwụ dị elu, mgbochi na nnu, , homonụ thyroid, ị doụ ọgwụ dị ukwuu.

Ihe analogues Glibenclamide bu: Glibeks, Glibamid, Gilemal, Glidanil, Betanaz, Antibet, Manin, Maninil, Maniglide.

Ihe ngosi maka oge atọrọ

Seconddị ọrịa shuga nke abụọ bụ ọrịa na-aga n'ihu nke chọrọ ọgwụgwọ na-aga n'ihu. Ọbụna n'ọnọdụ nke njikwa glycemic dị mma, ọrụ nke mkpụrụ ndụ beta ji nke nta nke nta na-akawanye njọ n'ebe ndị ọrịa ma nwee ọ̀tụ̀tụ̀ insulin na-emepụta n'ime ha na-ebelata. Site na shuga dị elu mgbe niile, usoro mbibi sel na-agbatịkwu. A ga - achọpụta mgbanwe nke izizi na insulin n’oge a chọpụtara ya. N'ime ụfọdụ ndị ọrịa, ha anaghị emetụta oke shuga, ma kwụọ ụgwọ maka ọrịa shuga, naanị nri kwesịrị ekwesị, metformin na agụmakwụkwọ anụ ahụ zuru ezu.

Ndị ọrịa mamịrị, ndị mkpụrụ ndụ beta na-enweghị ike ịrụ ọrụ maka onwe ha na maka ụmụnna nwụrụ anwụ, ga-edepụta akwụkwọ nzuzo. Ha na - akpali njikọ nke insulin, na - eme ka mkpụrụ ndụ rụọ ọrụ ike.

Mgbe edere glibenclamide:

1. A na-ahụ ọgwụ ahụ dịka otu n'ime akwụkwọ nzuzo kachasị sie ike, ya mere, egosiri ya maka ndị ọrịa nwere ọrịa shuga nwere mgbatị dị ukwuu nke insulin nke aka ha, dị ka egosipụtara site na nnukwu glycemia n'oge nchọpụta. Site na ọrịa mellitus decompensated, mmezi anaghị eme ngwa ngwa, glucose ji nwayọ belata ihe dị ka izu abụọ. Ndị ọrịa mamịrị nwere obere hyperglycemia anaghị enye ọgwụ ọgwụ ozugbo ha nyochachara ọrịa shuga.
2. A na-egosi Glibenclamide maka ike ọgwụgwọ na mgbakwunye na ndị ọzọ. Ọ dịla anya egosipụtara na ọtụtụ ọgwụ ịbelata shuga na-emetụta ihe kpatara hyperglycemia site n'akụkụ dị iche iche dị irè karịa otu. Iji mee ka nchịkwa metabolic dịkwuo elu, enwere ike ijikọta glibenclamide na insulin na mbadamba ọ bụla na-ebelata shuga, ma e wezụga PSM na ụrọ.

Mgbe ị na-ede ọgwụ ahụ, ekwesịrị iburu n'uche na ọ na-eme ka mkpụrụ ndụ beta na-arụ ọrụ na ike dị ukwuu. Dabere na nyocha, ụdị mkpali ahụ na-eduga n'ibelata obere oge na ndụ ha. Ebe ọ bụ na glibenclamide bụ ihe kachasị ike na ndị otu ya, a na-ekwukarị mmetụta a maka ya karịa maka PSM ọhụụ. Ọ bụrụ na onye na-arịa ọrịa shuga na-achọ ịnọgide na-arụ ọrụ insulin ruo ogologo oge o kwere mee, a ga-eyigharị ọgwụgwọ glibenclamide ruo mgbe ọgwụ ndị na-esighị ike kwụsị ịchịkwa ọrịa shuga.

Olee otú glibenclamide si arụ ọrụ

Usoro nke glibenclamide ghọtara nke ọma ma kọwaa ya n'ụzọ zuru ezu na ntuziaka maka ọgwụ. Ihe ahụ na-egbochi ọwa KATF nke dị na membrane beta-cell, nke na-eduga ná nkwụsị nke mkpụrụ ndụ n'ime mkpụrụ ndụ, na-eme ka ike gwụ mkpụkọ ahụ na ntopute nke ọdụdụ calcium. Mmụba na mkpokọta kalsel na sel na-akpali usoro ịhapụ insulin n'ime ya na mmiri intercellular, wee banye n’ime ọbara. A na-ebelata glucose n’ihi ikike insulin na-ebufe ya n’arụ ọbara n’arụ akwara. Glibenclamide na-arụsi ọrụ ike karịa PSM ndị ọzọ na-ejikọ ndị na-anabata beta-cell, yabụ ọ nwere mmetụta mmụkọ kachasị mma.

Ike nke ọgwụ na-abawanye site na ịba ụba ọgwụ. Nsonaazụ nke glibenclamide abụghị nke glycemia, ọgwụ ahụ na-arụ ọrụ na oke glucose yana yana nke na-ezughi oke, yabụ mgbe ị na-ewere ya, ịkwesịrị ịkpachara anya dị ka o kwere mee ma tụọ shuga mgbe akara ọ bụla yiri hypoglycemic.

Na mgbakwunye na hypoglycemic bụ isi, nsonaazụ mgbakwunye ọzọ bụ njirimara PSM niile. Dịka ntuziaka ahụ si dị, glibenclamide dị ntakịrị belata insulin iguzogide sel akwara na abụba, nke na-enye aka na mbelata glucose ọzọ.

A nyochachara mmetụta cardivascular ahụ iche. Ọ tụgharịrị na glibenclamide nwere ike igbochi ọwa KATF ọ bụghị naanị na mkpụrụ ndụ beta, kamakwa na mkpụrụ ndụ obi - cardiomyocytes. N'ikwu ya, ime ụdị ihe ahụ nwere ike ịka njọ nsị obi na-arịa ndị ọrịa mamịrị. N'ime ule nke ụlọ ọgwụ, e gosipụtaghị mmetụta dị n'akụkụ a. Ọzọkwa, achọpụtara ọgwụ antiarrhythmic a na-akpọ na glibenclamide, nke na-ebelata ọnwụ na oge ọrịa ischemia. Dabere na ndị dọkịta, ọtụtụ n'ime ha na-atụ egwu ịkọ ọgwụ Glibenclamide maka ọrịa obi ọ bụla chọpụtara, n'agbanyeghị data nyocha.

Nkwadebe nke Glibenclamide

Imirikiti ndị ọrịa mamịrị maara nke ọma glibenclamide nke ọgwụ Maninil, nke Berlin-Chemie mepụtara na Germany. Ọgwụ a bụ nke mbụ, ya na imesa ya ọnụ ọgụgụ ọmụmụ ihe ka emegoro nke mụọ amụrụ nrụmọrụ yana nchekwa nke glibenclamide. Maninil nwere nhọrọ usoro ọgwụgwọ 3. Na mbadamba nke 1,75 na 3.5 mg, ihe na-arụ ọrụ dị n'ụdị micronized pụrụ iche, nke na-enye ohere iji belata ọgwụ glycemia na obere ọgwụ. 5 mg maninyl nwere oge gboo glibenclamide.

Analogs na Russia bụ:

• Statiglyn sitere na Pharmasintez-Tyumen na Glibenclamide sitere na ụlọ ọrụ Ozone (aha ya bụ Atoll LLC). Ọgwụ ndị a nwere otu usoro onunu ogwu, mana ndị rụpụtara ekwuputaghị ọnụnọ microlized glibenclamide na nhọrọ ọ bụla.
• Mbadamba ọgwụ Glibenclamide nke Moskhimpharmpreparaty, Pharmstandard-Leksredstva, Biosynthesis, Valenta Pharmaceuticals nwere otu usoro ọgwụ nke 5 mg. Enwere ike kewaa ha iji nweta ọkara nke 2.5 mg.

Ọ dị mma ịmara na ha bụ nanị analogues anụ ahụ na-ahụ maka ọnọdụ, ebe ọ bụ na ụlọ ọrụ na-azụta glibenclamide ná mba ọzọ, tumadi na India. Nanị ihe dị iche bụ Statiglin, edebanyere aha na 2017. A na-emepụta Glibenclamide maka ya na Russia na ụlọ ọrụ BratskKhimSintez.

A na-anwale manloil analogues niile maka bioequivalence ma nwee ụdị ihe mejupụtara. Nyocha ndị ọrịa na-egosi na ọgwụ ndị a dịkwa irè, ma ọ ka na-arịa ọrịa shuga na-ahọrọ ịzụta ọgwụ mbụ, n'ihi aha ya buru ibu na obere ọnụ ala.

Na-ekpe ikpe site na nyocha, nchikota nke glibenclamide na metformin bụkwa ihe a ma ama. Ihe abuo ahu bu akuku nke ogwu abuo abuo Glucovans, Glimecomb, Gluconorm. Metglib, Glibomet na ndị ọzọ.

Onye nnabata nke contraindicated

Ntụziaka ahụ na-ewebata mmachibido iwere mbadamba Glibenclamide n'ọnọdụ ndị a:

• ọ bụrụ na ọgwụ ahụ ma ọ bụ ihe analogues ya nwere nke mbụ.
• mgbe onye na-arịa ọrịa shuga na-enweghị sel beta (ụdị shuga 1, ọrịa ntụgharị),
• na ọnọdụ ajọ ọrịa mellitus nke ọrịa shuga na ketoacidosis ma ọ bụ n'ihe egwu dị ukwuu nke decompensation n'ihi nnukwu mmerụ ahụ na ọrịa,
• ya na nnukwu akwara na oruru akwara
• n'ihe banyere ekweghị na lactose, nke a na-ahụ n’ime ọgwụ dịka ihe inyeaka,
• n’oge ime, lactation,
• na ọrịa shuga.

Site na ịkpachapụ anya dị oke mkpa, ọ dị mkpa iji mepụta ọgwụgwọ maka nsogbu hormonal, ahoụrụma, ọrịa nri, na nká, na oke okpomọkụ.

Glibenclamide analogs na nnọchi

Ihe analogues kacha nso nke glibenclamide bu ihe ndi ozo nke sulfonylureas. Ka ọ dị ugbu a, a na-eji glyclazide, glimepiride eme ihe, glycidone dị obere.

Ndị na-anọchi mbadamba ihe ndị glibenclamide dị ọnụ ala:

Gliptins, nke na-akpalikwa insulin njikọ, bụ ihe analogues glibenclamide dị ọnụ karịa. Glyptins bụ akụkụ nke Januvii, Ongliza, Xelevia, Galvus, Trazhenty, ọgwụgwọ ha dịkarịa ala 1500 rubles. kwa ọnwa. Ọgwụ ndị a anaghị akpata hypoglycemia, adịghị enye aka na mbibi nke mkpụrụ ndụ beta, mana anaghị ebelata shuga ngwa ngwa dị ka glibenclamide. Dabere na nyocha, glyptins na-enye nsonaazụ ka mma na mbido adịghị elu glycemia.

Ọnụahịa dị na ahịa ọgwụ

Maninil nwere microlized glibenclamide na-akwụ ụgwọ 130-160 rubles. kwa otu mbadamba 120. Maninil 5 mg ga-adị ọnụ ala, ọnụahịa nke mkpọ dị ihe dịka 120 rubles. Ofgwọ nke analogues nke ụlọ dị ntakịrị ọbụna: site na 26 rubles. maka mbadamba 50 ma ọ bụ 92 rubles. maka mbadamba 120. Ya mere, ọbụlagodi na oke ọnụọgụ ọgwụ, ọnụahịa ọgwụgwọ anaghị agafe 100 rubles. kwa ọnwa.

Enwere ike inweta ọgwụ Glibenclamide na-akwụghị ụgwọ na mpaghara ọ bụla nke Russia, ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa mellitus, ọ debara aha ya na endocrinologist.

Nyocha na Glibenclamide

Ọtụtụ mgbe, nyocha nke Glibenclamide bụ mkparịta ụka banyere usoro ọgwụgwọ eji eme ihe na ndị ọrịa nwere ọrịa mellitus. Ọ kachasị ndị ọrịa na-akọ na ị takingụ ọgwụ a dị ka monotherapy, agbanyeghị, ụfọdụ ndị mmadụ ka edepụtara ya dịka akụkụ nke ọgwụgwọ njikọta, ya bụ, yana ọgwụ hypoglycemic ọzọ. Mgbe ụfọdụ ndị ọrịa nwere ajụjụ n'ihi oke ike ma ọ bụ ezughi oke nke glibenclamide.

Ndị ọkachamara kwenyere na ebumnuche ọgwụ a kwesịrị ịbụ nke mmadụ, ekwesịrị ịhọrọ usoro ọgwụgwọ n'ọrịa ọ bụla.Yabụ, iwere Glibenclamide dị ka usoro ndị na-anọghị ya si bụrụ ihe siri ike ma nwee ike ibute ahụike. Ekwesịrị ịtụle ọtụtụ ihe, dịka ọmụmaatụ, ọkwa shuga ọbara nke onye ọrịa n'ọnọdụ dị iche iche. Naanị na nke a, enwere ike iche na ị takingụ ọgwụ ahụ ga-eme ka ọdịmma onye ọrịa dịkwuo mma.