Amitriptyline Nycomed - ntuziaka maka ojiji

Amitriptyline Nycomed: ntuziaka maka ojiji na nyocha

Aha Latin: Amitriptyline-Nycomed

Koodu ATX: N06AA09

Ngwakọta ọrụ: amitriptyline (Amitriptylinum)

Onye na-emepụta ihe: Takeda Pharma A / S (Denmark), Nycomed Danmark ApS (Denmark)

Na-emelite nkọwa na foto: 10/22/2018

Ahịa dị n'ụlọ ahịa ọgwụ: site na 54 rubles.

Amitriptyline Nycomed - ọgwụ na-eme ihe na-emegide antidepressant.

Mwepụta wepụtara ya na ihe mejupụtara

Usoro onunu ogwu nke mwepu nke Amitriptyline Nycomed:

• Mbadamba ụrọ (50 nke ọ bụla n'ime karama gbara ọchịchịrị, karama 1 n'ime igbe kaadiboodu),
• Mbadamba ihe eji etinye ihe nkiri: ọcha, biconvex, okirikiri (50 nke ọ bụla na karama gbara ọchịchịrị, karama 1 na kaadiboodu).

Ihe dị n’ime mejupụtara nke mbadamba 1, ihe mkpuchi / ihe nkiri: amitriptyline - 10 ma ọ bụ 25 mg.

Ngwa inye aka na mejupụtara nke mbadamba 1 gbara agba: microcrystalline cellulose, polypropylene glycol, sitara steeti, magnesium sterete, lactose monohydrate, titanium dioxide, talc, methyl hydroxypropyl cellulose, ọka ọka, gelatin, slopum slopum, polyvidone ọcha.

Ngwa inye aka na mebere mbadamba 1, ihe nkiri (10/25 mg):

• isi: magnesium stearate - 0.25 / 0,5 mg, povidone - 0.83 / 0.6 mg, talc - 2.25 / 4.5 mg, microcrystalline cellulose - 9.5 / 18 mg, stachi nduku - 28 , 2/38 mg, lactose monohydrate - 27 / 40.2 mg,
• shei: propylene glycol - 0.2 / 0.3 mg, titanium dioxide - 0.8 / 0.9 mg, hypromellose - 1.2 / 1.4 mg, talc - 0.8 / 0.9 mg.

Mlọ ọgwụ

Amitriptyline Nycomed bụ otu n'ime ọgwụ mgbochi tricyclic sitere na otu nke ndị na - achọghị nhọrọ monoamine reuptake inhibitors. Ọ nwere akpọrọ timoanaleptik na mmetụta ogwuura.

Ejikọtara usoro nke ime ihe na mmụba nke ọdịnaya serotonin na norepinephrine na synaptift cleft na Central ụjọ. Nkpakọba nke neurotransmitters ndị a na - apụta n'ihi ihe mgbochi nke njigide ọnụnọ nke ndị na - ahụ maka ikuku.

Amitriptyline bụ onye na-egbochi ndị na-anabata alpha-1-adrenergic ndị na-anabata ya, ndị na-anabata H1-histamine, M1- na M2-muscarinic cholinergic receptors. Dabere na nke a na-akpọ ncheta monoamine, enwere mmekọrịta n'etiti ọrụ nke neurotransmitters na synapses nke ụbụrụ na ụda mmetụta.

E gosiputara nkwekorita doro anya dị n'etiti mkpokọta plasma nke amitriptyline n'ime ọbara na mmetụta ụlọ ọgwụ, mana ọ nwere ike bụrụ na arụmọrụ kachasị mma nke ụlọ ọgwụ na-enweta na mkpokọta nke sitere na 100 ruo 260 μg / L.

A na-enweta mbelata nke ịda mbà n’obi site na izu 2-6 nke ọgwụgwọ (emesịrị nlebara anya plasma plasma na ọbara ahụ).

Amitriptyline Nycomed nwekwara mmetụta yiri nke quinidine na imepụta obi.

Mlọ ọgwụ

Amitriptyline mgbe nchịkwa ọnụ gachara kpam kpam na ngwa ngwa site na eriri afọ. Maximummata ohere ịta plasma kachasị (C_max) ahụrụ ka awa 2-6 gachara.

Ngwakọta plasma nke amitriptyline n'ọbara nke ndị ọrịa dị iche iche nwere ike ịdị iche iche. Usoro ndu nke amitriptyline bu ihe dika 50%. Ihe dị ka 95% nke ihe ahụ na-egbochi protein ndị dị na plasma. Oge iji ruo ịta kachasị (Tc_max) mgbe ingestion bụ 4 awa, ịta ọkwa bụ ihe dịka 7 ụbọchị site na mmalite ọgwụgwọ. Olu nkesa - dịka 1085 l / n'arọ. Nri ahụ na-agafe Plasenta ma na-abụpụ ya n’ime mmiri ara.

Metabolism pụtara na imeju, ihe dịka 50% bụ metabolized n'oge akụkụ mbụ nke gafere. Na mgbakwunye, amitriptyline na-ata ahụhụ N-demethylation site cytochrome P450 na ntinye nke na-esote metabolite na-arụ ọrụ - northriptyline. Ihe ahụ na metabolite ya na-arụ ọrụ bụ hydroxylated na imeju. N-hydroxy-, 10-hydroxymetabolite nke amitriptyline, 10-hydroxynortriptyline nwekwara ọrụ. Amitriptyline na northriptyline nwere glucuronic acid (conjugates anaghị arụ ọrụ). Isi ihe na-ekpebi mkpochapụ akwara na itinye uche plasma n'ime ọbara bụ ọnụego hydroxylation. Na obere pasent ndị ọrịa, a na-achọpụta hydroxylation egbu oge (nwere ọrịa mkpụrụ ndụ ihe nketa). Na ọnụnọ ọrụ ịba ọcha n'anya, ọkara nke amitriptyline / northriptyline na plasma ọbara na-abawanye.

Ọkara ndụ (T1 / 2) nke amitriptyline sitere na plasma ọbara bụ site na awa 9 ruo 46, northriptyline sitere na 18 ruo 95 awa.

Ntụrụndụ na-adịkarị n'ụdị metabolites site na akụrụ yana site na eriri afọ. N’ọnọdụ na-agbanweghi agbanwe, naanị obere akụkụ nke ọgwụ a na-ewepụta na-apịpụta n’akụrụ akụrụ. Site na arụ ọrụ ezumike n’akuku, metabolism nke amitriptyline na northriptyline anaghị agbanwe, n’agbanyeghi na mkpochapu ha na-ebelata. Anaghị ewepụ Amitriptyline sitere na plasma ọbara site na akwara (site na nkwukọrịta na protein protein).

Ihe ngbanwe

• infarction myocardial (gụnyere akụkọ mere n'oge na-adịbeghị anya)
• nnukwu ọrịa
• nnukwu mmanya ịxụbiga mmanya ókè,
• nnukwu ịxụ ọgwụ ọjọọ na ọgwụ ịrahụ ụra, mmetụta na ụbụrụ psychotropic,
• mmechi mmechi
• arrhythmias
• ọgba aghara nke usoro ọmụmụ intraventricular / atrioventricular,
• lactose anabataghị, ụkọ lactase na glucose-galactose malabsorption,
• prostate hyperplasia na njide nke urinary,
• bradycardia
• hypokalemia
• ahụ mkpọnwụ akpọnwụ akpọnwụ, pyloric stenosis,
• congenital elongated QT syndrome, yana njikọta ọgwụ na ọgwụ na-eduga na ịgbatị nke oge QT,
• ngwakọta ọgwụgwọ na monoamine oxidase inhibitors, gụnyere oge nke 14 ụbọchị tupu eji,
• afọ ruo afọ 18
• lactation
• mmadụ inabata ya na ọgwụ ndị ahụ.

Ikwu (na ntinye nke Amitriptyline Nycomed, ịkpachara anya na nlekọta ahụike chọrọ):

• ọrịa nke ọbara na akwara obi, gụnyere angina pectoris na ọbara mgbali elu,
• nnukwu akuku igwefoto nke anya na ezigbo ihu igwefoto nke anya,
• mmechi mmechi
• ụba intraocular mgbali,
• njigide urinary
• hyperplasia prostatic,
• Akwụkwụ na-adọ (iji Amitriptyline Nycomed nwere ike ibute mbelata mbata na-amaghị ama),
• Ọnọdụ nkwenye
• hyperthyroidism
• eriri afo,
• schizophrenia
• Ọrịa ụbụrụ
• imeju ma ọ bụ ọrụ akụrụ
• egbu egbu egbu,
• jikọtara ọgwụ maka ọgwụ ụra na ọgwụ ụra,
• tụụrụ ime
• nká.

Ntuziaka maka iji Amitriptyline Nycomed: usoro na usoro onunu ogwu

A na-ewere ọnụ okwu amitriptyline mbadamba 25 mg ma ọ bụ 10 mg ọnụ, ọkacha mma ozugbo nri. Mbadamba nkume ihu igwe ekwesịghị.

Usoro usoro onunu ogwu maka ndi oria okenye bu: na nmalite ogwugwo - 25-50 mg na usoro onwa abuo, ma oburu na odi nkpa, uda ubochi ka eji abawanye rue 200 mg, oge eji ya bu onwa 6 ma obu karie (iji gbochie nlọghachi).

Ọgwụ mbụ kwa ụbọchị nke Amitriptyline Nycomed maka ndị ọrịa agadi bụ 25-30 mg na ọgwụ 1 (n'abalị). Ọ bụrụ na ọ dị mkpa, ruo mgbe ọ ga-enweta nsonaazụ ọgwụgwọ, a na-abawanye ọgwụ a kwa ụbọchị ruo 50-10 mg kwa ụbọchị. Itinye akwụkwọ maka nkuzi nke abụọ chọrọ nyocha ọzọ.

Site na ọrịa imeju, a na-edobe ya Amitriptyline Nycomed na usoro belatara.

Iji zere ọdịdị nke nrechi ọrịa (n'ụdị isi ọwụwa, ọgba aghara ụra, iwe na ahụike ahụike n'ozuzu), a ga-ewepụ ọgwụ ahụ nwayọ. Mgbaàmà ndị a kpọrọ aha abụghị ihe ịrịba ama nke ịenceụ ọgwụ.

Nsonaazụ

Effectsfọdụ mmetụta ndị a na - adịghị mma (ọkachasị, ịma jijiji, isi ọwụwa, ọgbụgba mmekọahụ na ntanetị, oge ntachi) nwere ike bụrụ ihe mgbaàmà nke ịda mba, ha na - apụtakarị na obi iru ala.

Ihe kariri 50% nke ndị ọrịa n'oge eji Amitriptyline Nycomed nwere ike ịmalite otu ma ọ bụ karịa nke nsogbu ndị na-esonụ. Ọgwụ nwere ike iduga mmepe nke mmeghachi omume ọjọọ, nke yiri nke na-akpata ọgwụ ndị ọzọ tricyclic antidepressants.

Ihe mmeghari omume enwere ike (> 10% - otutu oge,> 1% na 0.1% na 0.01% and

Dodoụbiga ya ókè

Ihe ịrịba ama nke ịdoụbiga ọgwụ ókè nwere ike ịpụta na mberede ma ọ bụ jiri nwayọ. N'ime elekere abụọ mbụ, onye ọrịa ahụ nwere mgbakasị psychomotor ma ọ bụ ụra, ihe ndọghachi azụ, yana mgbaàmà n'ihi ọrụ anticholinergic nke amitriptyline (tachycardia, mucous membranes akọrọ, fever, mydriasis, njigide nke urinary, nkwarụ na enweghi ike ịgbatị eriri afọ). Mgbe nke a gasịrị, ọdịda nke iku ume, inhibido ọrụ nke sistemụ akwara etiti yana oke mkpali (ruo coma).

Ndị ọrịa dị iche iche nwere mmeghachi omume dị iche iche maka oke ịseụbiga mmanya ókè, ndị ọrịa ụmụaka na-enwekarị mmeghachi omume obi na ọdịdọ.

Site n'akụkụ nke sisitemu akwara obi, Amitriptyline Nycomed gosipụtara nke ukwuu site na fredter na ventricular fibrillation, ventricular tachyarrhythmia. A na-achọpụta mgbanwe ndị a na ECG: mgbasawanye nke usoro QRS, nbibi ma ọ bụ nwuo nke ebili mmiri T, ịgbatị oge PR, ịda mbà nke akụkụ ST, ịgbatị oge nke QT, na ogo dịgasị iche nke igbochi ụzọ transracardiac (ruo na njide obi). Onye ọrịa ahụ nwere ike ịmalite hypotension akwara, nkụchi obi, hypokalemia, ụkwara ume ọkụ, metabolic acidosis, oke ụjọ, ataxia, ọgba aghara na ndọta. Ihu ura siri ike nwekwara ike ime.

N'ihe banyere iji Amitriptyline Nycomed na ọnụọgụ dị elu karịa nke nchekwa, ma ọ bụ ọdịdị nke akara nke ị anụbiga mmanya ókè, edepụtara usoro ọgwụgwọ na nkwado. Ekwesịrị ịkwụsị ị therapyụ ọgwụ ọjọọ. A na-eji afọ eme onye ọrịa ahụ ya ka ọ bụrụ unyi arụ ọrụ (ọ bụrụgodị na oge ụfọdụ agafeela mgbe ọ gachara amitriptyline). Ekwesịrị iji nlezianya nyochaa onye ọrịa ahụ, n'agbanyeghị ọnọdụ dị mma. Ọ dị mkpa ijikwa ọ̀kụkụ iku ume na ọkwa nke obi, ogo nke mmụọ na ọnụọgụ ọbara. A choro ka ichoputa itinye uche ndi gas na electrolytes n'ime obara. Gbaa mbọ hụ na ikuku gas na-adịkarị ma, ọ bụrụ na ọ dị mkpa, mee ikuku na-arụ ọrụ. A na-enyocha ECG maka ụbọchị 3-5 mgbe ịdoụfere oke. Enwere ike ịkwụsị arrhythmias Ventricular, nkụda obi na mgbasawanye nke ihe QRS site na ịgbanye pH n'akụkụ akụkụ alkaline (site na hyperventilation ma ọ bụ ịkọwa sodium bicarbonate solution) na ntinye ngwa ngwa nke sodium chloride solution (100-200 mmol Na +). N'ime ndị ọrịa nwere ventricular arrhythmias, enwere ike iji ọgwụ ọdịnala antiarrhythmic mee ihe dịka ọmụmaatụ intravenous management nke 50-100 mg lidocaine (1-1.5 mg / kg) sochiri infusion na ọsọ nke 1-3 mg / min.

Ọ bụrụ na ọ dị mkpa, tinye defibrillation na cardioversion. A na-arụzi mmezi nke enweghi ike inye ọbara ọbara site na usoro iji dochie anya plasma, na n'ọnọdụ ndị siri ike, site na mgbakwunye dobutamine (mkpụrụ mbụ bụ 2-3 μg / kg / min, na-esochi mmụba ya, dabere na nsonaazụ a nwetara) Enwere ike iji diazepam kwusi mkpesa na mkpasu iwe.

Ọgwụgwọ metabolic acidosis bụ ọkọlọtọ. Nyocha iji wepụta amitriptyline na ọbara adịghị arụ ọrụ, ebe ọ bụ na ntinye uche nke ihe na-adịghị na plasma dị ala.

N'ime ndị ọrịa okenye, mmịnụ ọgwụ oke na oke oke ma ọ bụ nke siri ike na ọgwụ ahụ na-ebilite mgbe were 500 mg ma ọ bụ karịa nke amitriptyline. Ọ bụrụ na i were 1000 mg ma ọ bụ karịa, nsonaazụ na-egbu egbu ga-ekwe omume.

Ntụziaka pụrụ iche

Tupu ịmalite usoro ọgwụgwọ na Amitriptyline Nycomed, ọ dị mkpa iji chịkwaa ọbara mgbali, dịka na ndị nwere labile ma ọ bụ ọbara mgbali dị ala, ọ nwere ike ibelata ọbụna karịa.

Ndị ọrịa agaghị ebili ọtọ ma ọ bụ nọrọ ọdụ. Ọmụmụ ihe (ọnụọgụ nke ndị ọrịa a mụrụ afọ 50 na karịa) gosiri na ojiji nke tricyclic antidepressants na nhọrọ serotonin reuptake inhibitors na-eme ka ọghọm ọkpụkpụ daa, n’agbanyeghi, usoro nke usoro a na ogo ihe ize ndụ amabeghị.

N'oge ọgwụgwọ, a na-atụ aro ka ịchịkwa ihe mejupụtara ọbara na-emetụta oke (ọkachasị na mmepe nke tonsillitis, ahụ ọkụ ma ọ bụ ọdịdị nke mgbaàmà dị ka nke flu), yana iji ogologo oge ọgwụgwọ - ọrụ nke imeju na akwara obi. N'ime ndị ọrịa nwere ọrịa nke usoro obi na ndị agadi, ọ dị mkpa ijikwa ECG, ọbara mgbali elu na ọnụego obi.

Ejiri Amitriptyline jiri nlezianya n'otu oge na ndị inducers ma ọ bụ ndị na-egbochi cytochrome P₄₅₀ CYPZA4.

N'oge ọgwụgwọ, ọ dị mkpa ịhapụ ị ofụ mmanya na-aba n'anya.

Ekwesiri iji nwayọ wepụ ọgwụ ọjọọ, ebe ọ bụ na mwepu nke nnabata na mberede, ọkachasị mgbe ogologo oge gachara, nwere ike ibute mmepe nke ọrịa mwepụ.

Ọrụ M-anticholinergic nke amitriptyline nwere ike ime ka mwakpo nke intraocular mgbali. Ọ ga - ekwe omume belata lacrimation ma mee ka ọnụọgụ abụọ dị na mmiri lacrimal, nke nwere ike ibute mbibi nke mpụga cornea ahụ n’ebe ndị mmadụ na - eji elensi anya ele anya.

N'ime omume ụlọ ọgwụ, okwu banyere ọnwụ n'ihi arrhythmia nke na-apụta awa 56 ka a kọwara ọgwụ ịdoụbiga mmanya ókè.

N'ime ndị ọrịa nwere ebumnuche igbu onwe ha, ndị mmadụ igbu onwe ha na-adịgide n'oge ọgwụgwọ ruo mgbe a ga-enwe ọganihu dị ukwuu na mgbaàmà nke ịda mbà n'obi. Ebe ọ bụ na usoro ọgwụgwọ amitriptyline bidoro ịpụta naanị mgbe izu 2-4 gachara, a na-achọ nlezianya nke ndị ọrịa na-egbu onwe ha ruo mgbe ọnọdụ ha ga-aka mma. Ndị mmadụ kwuburu echiche igbu onwe ha ma ọ bụ ihe igbu onwe ha, yana ịnwa igbu onwe ha tupu ịmalite ọgwụgwọ ma ọ bụ n'oge ọgwụgwọ, kwesịrị ịnọ n'okpuru nlekọta ahụike mgbe niile. Ọ bụ ndị mmadụ nyere ikike ka ekesara ọgwụ ndị a. Amitriptyline Nycomed (dị ka ọgwụ ndị ọzọ na-egbochi igbu onwe ya) nwere ike iwelie ugboro ugboro igbu onwe ya na ndị ọrịa na-erubeghị afọ iri abụọ na anọ, yabụ, tupu ịdepụta ọgwụ ahụ nye ndị ọrịa na-erubeghị afọ iri abụọ na anọ, ọ dị mkpa ikpebi nha uru nke iji ya na ihe egwu nke igbu onwe ya.

N'ime ndị nwere ọrịa manic-depress syndrome, amitriptyline nwere ike ibute ọdịdị nke usoro manic. N'ihe banyere mgbaàmà manic, ekwesịrị ịkwụsị ọgwụ a.

N'ime ndị ọrịa na-anata ọgwụ mgbochi atọ ma ọ bụ tetracyclic n'otu oge na ọgwụ izugbe ma ọ bụ mpaghara, ohere nke ibelata ọbara mgbali na mmepe nke arrhythmia nwere ike ịba ụba. Ọ bụ ya mere o ji dị mma ịkagbu ọgwụ ahụ tupu ịwa ahụ ịwa ahụ. N'ihe banyere nsogbu ịwa ahụ mberede, ekwesịrị ịgwa onye na-ahụ maka akụnwụ ahụ banyere iji amitriptyline.

Ọgwụ nwere ike imetụta ọrụ insulin ma gbanwee njupụta nke glucose na ọbara mgbe ị risịrị nri. N'ime ndị ọrịa nwere ọrịa mellitus, enwere ike ịchọ mgbazi nke ọgwụgwọ ahụ. Ọnọdụ ịda mba n'onwe ya nwere ike ịgbanwe metabolism.

Ndị mmadụ na-ewere Amitriptyline Nycomed kwesịrị ịgwa dent ha banyere ị takingụ ọgwụ.Ọnụ a na-akpọ nkụ nwere ike ibute mbufụt, mgbanwe na mucosa nke ọnụ, sọks eze, na mmetụta na-enwu ọkụ n'ọnụ. A na-adụ ndị ọrịa ọdụ ileta dọkịta ezé mgbe niile.

Ime na lactation

Ahụmahụ na-adakarị ahụ na Amitriptyline Nycomed n'ime ụmụ nwanyị dị ime nwere oke. Emebebeghị nchekwa nke amitriptyline maka nwa ebu n’afọ.

Achọghị ọgwụ a ka edee ya n’oge afọ ime, ọkachasị n’ihe dị n’otu oge atọ na nke III, ewezuga n’ọnọdụ ebe uru anya nne ga-adị ga-aba n’iru nwa ebu n’afọ. Ọ dị mkpa ịdọ nwanyị dị ime aka banyere ihe egwu dị egwu nke mmetụta ọjọọ nke ọgwụ na-ebute n’afọ nwa ebu n’afọ, ọkachasị n’oge nke atọ. Ngwọta ọgwụ mgbochi tricyclic dị ukwuu nke ejiri na ọkara nke atọ nwere ike ibute nsogbu akwara ozi na ụmụ amụrụ ọhụrụ. Edekọwo akwụkwọ dị iche iche nke iri ụra na ụmụ aka ndị nne ha kuchara waqooyi mgbe ha dị ime, a hụkwara ikpe gbasara njide urinary n'ime ụmụ amụrụ ọhụrụ.

Na omumu ihe omumu, ihe ndi ozo gosiputara ogwu ahu bu mgbe ha were otutu ogwu bulie elu ogwu nke umu mmadu.

Amitriptyline na-apụ apụ n’oge a na-enye ya ara, yabụ, a ga-akwụsị ị breastụ ara mgbe a na-agwọ ya ọgwụ.

Mkparịta ụka ọgwụ ọjọọ

Amitriptyline Nycomed na-enye ike mgbochi nke usoro ụjọ ahụ site na ọgwụ ndị na-esonụ: narcotic na Central analgesics, antipsychotics, anticonvulsants, hypnotics and sedative, mmanya, na anesthetics izugbe.

Ọgwụ ndị na-egbochi CYP2D6 isoenzyme (isi isoenzyme bụ nke tricyclic antidepressants bụ metabolized) nwere ike igbochi metabolit amitriptyline ma nwekwuo itinye uche ya. Ọgwụ ndị dị ka: antipsychotics, ọgwụ ikpeazụ nke antiarrhythmic (propafenone, procainamide, esmolol, amiodarone, phenytoin), serotonin reuptake inhibitors (ewezuga citalopram, nke bụ ihe na-adịghị ike nke ukwuu), P-blockers.

Amitriptyline Nycomed bụ contraindicated ka e jiri ya mee ihe na MAO inhibitors, ebe ọ bụ na ngwakọta dị otú a na-eduga na mmepe nke ọrịa serotonin, nke gụnyere spasms mgbe ọ excitedụ, myoclonus, nsogbu nke uche na mmachi mara mma na coma. Enwere ike ịmalite ị drugụ ọgwụ ahụ izu abụọ ka akwụsịsịrị ọgwụgwọ na-enweghị mgbanwe, ndị na-adịghị ahọrọ MAO na-ahọrọ na otu ụbọchị mgbe mwepụ nke moclobemide (ntụgharị MAO inhibitor). N'aka nke ya, ọgwụgwọ na ndị na - egbochi MAO nwere ike ibido na mbido izu abụọ ka akachapụrụ Amitriptyline Nycomed. N'okwu abụọ na nke abụọ, ọgwụgwọ na MAO inhibitors na amitriptyline na-amalite site na obere usoro, nke na-emecha jiri nwayọọ nwayọọ.

A naghị akwado ọgwụ a maka iji otu oge na ọgwụ ndị a:

• ọrịa ime mmụọ (adrenaline, isoprenaline, phenylephhedrine, norepinephrine, ephedrine, dopamine): a na-eme ka mmetụta nke ọgwụ ndị a na sisitemu obi
• ndị na-egbochi mgbasa ozi adrenergic (methyldopa, clonidine): imebi ihe antihypertensive mmetụta nke ndị na-egbochi adrenergic na-egbochi ndị kwere omume,
• m-anticholinergics (ọgwụ sitere na phenothiazine, atropine, ọgwụ antiparkinsonian, biperiden, H blockers₁-histamine na-anabata ya): amitriptyline nwere ike ịkwalite nsonaazụ ọgwụ ndị a na eriri afọ, eriri afọ, akụkụ nke ọhụụ na sistemụ akwara, a ga-ezere iji nkwonkwo n'ihi ihe egwu nke mmụba dị elu na ọnọdụ okpomọkụ na mgbochi afọ,
• ọgwụ na-agbatị oge etiti QT (ọgwụ antiarrhythmic, ụfọdụ antipsychotics, H blockers)₁ndị na-anabata ọgwụ histamine, ọgwụ na-egbu egbu, sotalol, chloral hydrate): ihe egwu nke ịmalite ventricular arrhythmias na-abawanye,
• nnu nnu lithium: ọ ga - ekwe omume ịbawanye nsị nke lithium, nke ọdịdọ tonic-clonic gosipụtara, oke ịma jijiji, echiche na - ezighi ezi, ihe ijuanya, ncheta na ọrịa antipsychotic syndrome,
• ndị ọrụ antifungal (terbinafine, fluconazole): ọnụọgụ ọbara nke amitriptyline na-abawanye na nsí ọgwụ nke metụtara ya na-abawanye.

Ejiri Amitriptyline Nycomed jiri nlezianya n'otu oge na ọgwụ ndị a:

• ọgwụ na-egbochi usoro ụjọ ahụ (usoro nyocha siri ike, ọgwụ mgbochi na hypnotics, ethanol na ọgwụ ethanol nwere): enwere ike ịbawanye mgbochi nke ọrụ nke sistemụ akwara etiti,
• ndị na - eme ka enzymes imeju microsomal (carbamazepine, rifampicin): metabolism amitriptyline nwere ike ịbawanye elu ma itinye uche ya na plasma nwere ike ibelata, nke na - eduga n'ibelata ike nke mmetụta antidepressant,
• ọgwụ mgbochi: enwere ike igbochi metabolism ọnụ, nke nwere ike ibute mbelata ihe nbibi ma bute mmepe nke ọdịdọ (mgbe ụfọdụ achọrọ ịgbatị antipsychotics na amitriptyline),
• Ndị na-egbochi ngwa ngwa calcium na-egbochi ngwa ngwa, methylphenidate, cimetidine: plasma ịta nke amitriptyline na-abawanye na nsí ya na-abawanye,
• ọgwụ ịra ura na ọgwụ ịsa ụra: n’otu oge iji amitriptyline, ọgwụ ịrahụ ụra na ọgwụ ọgwụ anaghị atụ aro (ọ bụrụ na ọ dị mkpa, ojiji nke ngwakọta a kwesịrị ịkpachara anya karịsịa),
• acid a na-akpọ valproic acid: ịba ụba nke amitriptyline na northriptyline (nwere ike ịchọ mbelata nke ọgwụ),
• Na-ahụ ike: ịnwe amitriptyline adịghị ike ma na-ebelata nsụchi antidepressant ya,
• phenytoin: a machibidoro metabolictoin metabolism ya na-egbu egbu na-egbu egbu ya (ataxia, shoor, nystagmus na hyperreflexia kwere omume),
• nkwadebe nke hypericum perforatum: a na-eme ka metabolism nke amitriptyline n'ime imeju na itinye uche ya na plasma na-agbada (enwere ike ịchọ ndozi nke amitriptyline).

Ihe analogues nke Amitriptyline Nycomed bụ Amitriptyline, Amitriptyline Zentiva, Amitriptyline Grindeks, Vero-Amitriptyline, Amitriptyline-Ferein, Saroten retard, wdg.

Usoro onunu ogwu:

mbadamba ihe mkpuchi

Otu mbadamba tebụl gbara agba 10 mg nwere:
ike ọrụ: amitriptyline hydrochloride 11.3 mg na usoro nke amitriptyline 10 mg,
ndị na-ebu ụzọ: magnesium stearate 0.25 mg, povidone 0.83 mg, talc 2.25 mg, microcrystalline cellulose 9.5 mg, stachi nduku 28.2 mg, lactose monohydrate 27.0 mg,
shei: propylene glycol 0.2 mg, titanium dioxide 0.8 mg, hypromellose 1.2 mg, talc 0.8 mg.
Otu mbadamba 25-25 fiimu kpuchiri ekpuchi nwere:
ike ọrụ: amitriptyline hydrochloride 28.3 mg na usoro nke amitriptyline 25 mg,
ndị na-ebu ụzọ: magnesium stearate 0,5 mg, povidone 0.6 mg, talc 4.5 mg, microcrystalline cellulose 18.0 mg, nduku nduku 38.0 mg, lactose monohydrate 40.2 mg,
shei: propylene glycol 0.3 mg, titanium dioxide 0.9 mg, hypromellose 1.4 mg, talc 0.9 mg.

Nkọwa

Mbadamba mbadamba, ihe mkpuchi na-acha ọcha na agba, gburugburu, biconvex.

Nyocha banyere Amitriptyline Nycomed

Ọgwụ nwere ma nyocha dị mma ma na-adịghị mma. Ọ na-akwadoro maka iji ihe dịka 75% nke ndị ọrụ. Isi uru nke ọgwụ mgbochi: arụmọrụ, nnabata dị mma, ọnụahịa dị ala. Ọgwụ ahụ na-ewepụ nchekasị nke ọma, na-enyere aka na mgbu na-adịghị ala ala, enweghị ụra na mwakpo ụjọ, na-eme ka ahụ dị jụụ, na-eme ka ahụ ụjọ ahụ kwụsị, belata nkụda mmụọ na neurosis.

Ihe ọghọm nke Amitriptyline Nycomed, dị ka ndị ọrịa si kwuo, enwere ike inwe mmetụta n'akụkụ (agụụ na ụba na-abawanye, ọnụ na -ekwu, olu na -ekwulatalata, ọbara mgbali, ụra, wdg). Usersfọdụ ndị ọrụ na-eme mkpesa banyere enweghị ezigbo ngwaọrụ. Ọgwụ nwere ọtụtụ contraindications, a na-enye ya ọgwụ naanị, ọgwụ riri ahụ ga-ekwe omume, yabụ, achọrọ nwayọ nwayọ - ndị a bụ ọghọm isi ndị ekwuru na nyocha.

Ngwongwo ogwu

Amitriptyline bụ ọgwụ mgbochi tricyclic sitere na otu nke ndị na - achọghị nhọrọ monoamine reuptake inhibitors. O nwere nsonye ike thymoanaleptik na ogwuura.
Mlọ ọgwụ
Usoro nke usoro antidepressant nke amitriptyline jikọtara ya na mmụba nke ọdịnaya norepinephrine na serotonin na synaptift ke Central ụjọ system (CNS).
Nchịkọta nke ndị a neurotransmitters ndị a na - aputa ihe site na ihe mgbochi nke mkpochasị nke ọghọm nke mkpụrụedịịkịkị nke ikuku.
Amitriptyline bụ onye na-egbochi Ml na M2 muscarinic cholinergic ndị na-anabata, ndị na-anabata H1 histamine na ndị na-anabata ad er1 adrenergic. Dika ihe anakpo hypothesis, enwere nkwekorita n'etiti olu obi uto ya na oru ndi neurotransmitters na synapses nke ụbụrụ.
E gosiputara nkwekorita doro anya dị n'etiti mkpokọta amitriptyline na plasma ọbara na mmetụta ụlọ ọgwụ, mana mmetụta kachasị mma nke ụlọ ọgwụ, o doro anya na a na-enweta ya na mkpokọta na 100-260 μg / L.
A na-enweta mmebi nke ịda mba na-akpata ịda mbà n'obi ka e mesịrị karịa ntụle plasma ndọtị ruru, mgbe izu 2-6 nke ọgwụgwọ gasịrị.
Na mgbakwunye, amitriptyline nwere mmetụta yiri quinidine dị na ime obi.
Mlọ ọgwụ
Egwu
Mgbe nchịkwa ọnụ gachara, amitriptyline na-agbadata ngwa ngwa ma zuo ezu site na eriri afọ. A na-etinyekarị uche na plasma ọbara (Cmax) n'ime awa 2-6 ka nchịkwa gachara.
Nkesa
Ntinye uche nke amitriptyline na plasma obara nke ndi oria di iche di iche.
Usoro ndu nke amitriptyline bu ihe dika 50%. Amitriptyline buru ibu (95%) na - egbochi ihe nchebe plasma. Oge ị ga-eji nweta ntinye uche kachasị (TCmax) mgbe nchịkwa ọnụ bụ awa anọ, ma nwekwaa ịta ụta ahụ bụ otu izu mgbe mmalite ọgwụgwọ. Olu nke nkesa dị ihe dị ka 1085 l / kg. Ma amitriptyline na northriptyline gafere Plasenta na - apụ apụ na mmiri ara.
Metabolism
Amitriptyline bụ metabolized na imeju ma dịkwa nnukwu (ihe dịka 50%) metabolized oge izizi ọ na-agafe akwara. N'otu oge ahụ, amitriptyline na-ata ahụhụ N-demethylation site na cytochrome P450 na nguzobe nke metabolite na-arụ ọrụ - northriptyline. Abụọ amitriptyline na northriptyline na-hydroxylated na imeju. Nitroxy na 10-hydroxymetabolite amitriptyline na 10-hydroxynortriptyline na-arụkwa ọrụ. Abụọ amitriptyline na northriptyline na-emezi glucuronic acid, conjugates ndị a adịghị arụ ọrụ.
Isi ihe na-ekpebi mkpochapụ akwara, na, yabụ, itinye uche na plasma ọbara, bụ ọnụego hydroxylation. N'obere ndi mmadu, a na-ahuta hydroxylation nke anaghi egbu oge. N'ime ndị ọrịa nwere ọrụ imeju na -akwụsị, ọkara nke amitriptyline na northriptyline na plasma ọbara na-abawanye.
Ojiji
Ọkara ndụ (T1 / 2) site na plasma ọbara bụ awa 9-46 maka amitriptyline na awa 18-95 maka northriptyline.
Amitriptyline bụ nke kachasị site na akụrụ na site na eriri afọ n'ụdị metabolites. Naanị obere akụkụ nke ịnakwere dose nke amitriptyline ka dịpụrụ adịpụ site na akụrụ na-agbanweghi. N'ime ndị ọrịa nwere nsogbu akụrụngwa ezighi ezi, mwepụ nke amitriptyline na ugwu ugwu ugwu na-ebelata, n'agbanyeghị na metabolism dị ka nke a anaghị agbanwe. N'ihi mkpakọrịta ya na protein protein, ewepụrụ amitriptyline na plasma ọbara site na nyocha.

Ihe ngosi maka ojiji

• autism
• hypochondria
• ịda mba
• schizophrenic psychosis,
• bulimia nervosa
• akwa ụra,
• ọrịa mgbu na-adịghị ala ala
• oria ojoo
• prophylaxis migraine.

N'etiti ndepụta niile nke nsogbu akwara dị oke egwu, ekwesịrị iburu n'uche na ndị ọkachamara ka edepụtara ọgwụ ahụ maka ndị ọrịa cancer iji belata ihe mgbu. N'ihe banyere imebi ọnọdụ mmetụta uche na akparamagwa, ụjọ na-arịwanye elu, ọgba aghara ụra na ndakpọ olileanya, nkwụghachi ahụ na-enyere 100%, ọ dị mkpa icheta naanị na ọ bidoghi ime ihe ozugbo.

Ahịa maka amitriptyline dara nke ọma na ụlọ ahịa ọgwụ na Moscow

Ndi dibia nyocha na amitriptyline

Ahụmahụ nke iji Amitriptyline dị ka onye ọzọ na-ahụ maka ọgwụgwọ nke mgbu vertebrogenic emeela ka nkwubi okwu banyere ịdị irè nke ọgwụ a na ndị ọrịa nwere obere mgbu na-adịghị ala ala. Mmetụta ọgwụ ahụ dị ugbu a so mee ka usoro ihi ụra na-ehi ụra n'oge mgbede ọgwụ ahụ.

Amitriptyline. Nke a bụ nke mbụ. Na nke abụọ, enwere ike ịme ya site na akụrụngwa kachasị "dị ọcha" site na amitriptyline niile dị na mpaghara Kemerovo. O nwere usoro onunu ogwu nke 10 mg, nke dikwa adaba mgbe enyere ndi ọrịa oke nsogbu nnwere onwe na (ma obu) enwere nsogbu diri “antidepressants”.

Nsogbu ndị a na-ahụkarị maka amitriptyline: cardiotoxicity, ọkwa nke prolactin na ọbara, ịba ụba nke ahụ, ịmepụta cystitis ga-ekwe omume.

Amitriptyline kacha mma dị na ahịa nke mpaghara Kemerovo.

Ọtụtụ mgbe ọ na-akpata ụra ụra na nsogbu ọ na-akpata: ike ọgwụgwụ na isi, njide urinary, afọ ntachi.

Otu n'ime ọgwụ antidepressants kachasị ike, nke nwere mmetụta mgbochi ụjọ. Ọ dị mma na nkebi nkụda mmụọ, nkụda mmụọ ugboro ugboro, iwe na nkụda mmụọ na-adịghị mma. Enwere ike iji ya maka steeti na-akpata nkụda mmụọ, yana ehighị ụra nke ọma.

Nyocha nyocha nke ndị ọrịa gbasara Nycomed amitriptyline

Achọghị m ka onye ọ bụla nweta mmetụta m nwere n'ihi ọgwụ ọjọọ a! Dọkịta ahụ kwuru na m ga-anọ jụụ, mana adọghị aka na ntị na m ga-aghọ inine. Nke a bụ ụjọ! N'agbanyeghị ụdị echiche igbu onwe m dakwasịrị m, Amitriptyline bụ ụta. Egwu!

Otu dibia akwara gwara m Amitriptyline iji belata ọgụ mwepu. Medicinegwọ ọgwụ a dị naanị na ndenye ọgwụ, nke na-enweghị m mmasị, maka na mgbe ọgwụ na-agwụ, ị ga-aga ụlọ ọgwụ, kwụrụ n'ahịrị maka obere oge, mgbe ahụ ị nwere ike ịga ebe a na-ere ọgwụ maka ya. Mana nke a bụ naanị ọkara nsogbu, na-ewere ya ruo ọnwa isii, dị ka dọkịta ahụ nyere iwu, ọ nweghị mmetụta ọ bụla, enweghị mwakpo ndị ọzọ, ha amaliteghị ịpụcha mfe. O nwere ike ịdị irè na ọrịa ndị ọzọ, mana ọ bụghị na nke m.

Na 2017, ezutere m ọnọdụ dị ịtụnanya, nke yiri nkụchi obi, mana dịka ọ tụgharịrị mechara - mwakpo ụjọ. A kpọgara m n'ụlọ ọgwụ, na akwara ozi, ebe ahụ ka dọkịta depụtara m ọgwụ ndị a, ọgwụ mbụ bụ ọkara mkpụrụ ọgwụ n’abalị ma jiri nwayọọ nwayọọ mụbaa, nke mere m ji were ya dị ka atụmatụ ahụ si dị 0,5 0 0 0 (ụtụtụ, ehihie na mgbede) ), na mbụ enwere ụra na-ehi ụra, hie ụra nke ọma ma daa ụda, hie ụra! Nsonaazụ pụtara nke ọma n’izu abụọ, mgbe m jidere onwe m n’uche na ọnọdụ m dị oke mma na ọ dịghị ihe mere! A rejoụrịrị m ọ atụ na oke egwu ndị dị ka amamiihe anyanwụ, ahịhịa, egwu na-apụtabeghị mbụ mmetụta siri ike, n'oge a na-ewepụta nnukwu obi ụtọ. Ee, ee, enwekwara m ọmarịcha nrọ! Mgbe e mechara, belatara ọgwụ ahụ, ọgwụ enyere m aka nke ọma, ọ gara nke ọma.Mana ịchọrọ ige ntị na ọnọdụ gị, n'ihi na ọ dị otu onye.

Na ndu m, ahuru m oria dika ịda mba. Achọtara m onye nwere ọgụgụ isi, ọ degakwara m Amitriptyline. Ọgwụ dị mma n’ezie, na-anagide nchegbu, na-ewepụ ehighị ụra. Edere m na usoro onunu ogwu nke 20 mg n'abalị na 10 mg n'ehihie, n'oge na-adịghị anya, m kwụsịrị naanị otu usoro ọgwụgwọ n'abalị. Ọgwụ ahụ, ọ bụ ezie na ọ bụ agadi, mana na-anagide ọrụ ya. Ọtụtụ na-atụ egwu mmetụta ọ bụla, enweghị m ya, naanị ụra na-ehi ụra, mana ọ bụ n'aka m, n'ihi Ogologo oge tara ahụhụ ehighị ụra nke ọma.

Ọ bụ onye na-agwọ ọrịa nyere iwu "Amitriptyline", na-echegbu onwe ya. Ọgwụ dị mma, ọ bụrụ na edebere ya nke ọma ọ na-enyere aka n'ezie. Ọ dị mkpa ị drinkụ mkpụrụ ọgwụ ikpeazụ ruo mgbe elekere 20.00, ma ọ bụghị ya na-akpata obi ụtọ nke usoro ụjọ ahụ, ehighị ụra nke ọma. Ọ bụrụ n'ụra na-egosi, tachycardia - a ga-ebelata usoro a ga-ebelata. 1/4 nke 10 mg 2 ugboro n'ụbọchị na 1/2 nke 10 mg n'abalị nyere mmetụta dị mma na-adịgide adịgide. Enweghị mmetụta ọ bụla ma e wezụga tachycardia.

Ọgwụ Farmacology

Mkpochapu sitere na ngwakọta nke tricyclic, usoro nke dibenzocycloheptadine.

Usoro nke mmegide antidepressant nwere njikọ na mmụba nke mkpokọta norepinephrine na synapses na / ma ọ bụ serotonin na sistemụ akwara na-emetụta n'ihi mgbochi nke ngbanwe azụ nke neuronal nke ndị ọrụ mgbasa ozi a. Site na iji ogologo oge, ọ na-ebelata ọrụ nke ndị na-anabata β-adrenergic na ndị na-anabata serotonin na ụbụrụ, na-ahụ maka nnyefe adrenergic na serotonergic, ma na-eweghachi nguzozi nke usoro ndị a, nke na-agbagha na steeti ndị na-akụda mmụọ. Na steeti na-enwe nkụda mmụọ, ọ na-ebelata nchekasị, obi mgbawa na mgbaàmà nke obi mgbawa.

O nwekwara mmetụta analgesic, nke a kwenyere na ọ bụ n'ihi mgbanwe na ngbanwe nke monoamines na sistemụ akwara dị n'etiti, karịsịa serotonin, yana mmetụta na sistemụ opioid endogenous.

O nwere oke anticholinergic akpọrọ akpọrọ, n'ihi nnukwu mmekọrịta dị n'etiti ndị na-anabata m-cholinergic, mmetụta siri ike na-agakọ metụtara mmekọrita maka histamine H.₁-echeta ihe, na ihe alfa-adrenergic igbochi.

Ọ nwere mmetụta antiulcer, usoro nke bụ n'ihi ikike igbochi histamine H₂-ịbụ ọnya na mkpụrụ ndụ parietal nke afọ, ma nweekwa ọgwụ mgbochi na m-anticholinergic (bụrụ nke ọnya afọ na nke duodenum, ọ na-ebelata ihe mgbu, na-emekwa ngwa ịgwọ ọnya).

Izu oke na ide akwa bụ ihe kpatara ọrụ anticholinergic, na-eduga na mmụba ike nke eriri afọ iji gbatịa, mkpali β-adrenergic, ọrụ nke on-adrenergic agonists, tinyere mmụba nke ụda sphincter na etiti mgbochi nke serotonin uptake.

E guzobebeghị usoro ọgwụgwọ ọgwụgwọ na bulimia nervosa (ikekwe nke ahụ na nkụda mmụọ). E gosipụtara nrịba amitriptyline na bulimia na ndị ọrịa ma enweghị nkụda mmụọ yana ọnụnọ ya, ebe enwere ike ịhụ mbelata nke bulimia na-enweghị nkụda mmụọ na-eme ka ọ daa mbà n'onwe ya.

Mgbe ị na - eme mgbatị akwara, ọ na - agbada ọbara mgbali elu na okpomoku. Ọ naghị egbochi MAO.

Mmetụta ọgwụ antidepressant na - etolite n'ime izu 2-3 mgbe mmalite nke iji.

Mmekorita

Iji otu oge eji ọgwụ ọjọọ nwere mmetụta na-akụda mmụọ na sistemụ akwara nke etiti, mmụba dị ukwuu na mmetụta inhibitory na sistemụ akwara nke etiti, mmetụta antihypertensive, na nkụda mmụọ na-ekwe omume.

N'iji ọgwụ ọgwụ na-eme n'otu oge iji ọgwụ anticholinergic, mmụba na mmetụta anticholinergic ga-ekwe omume.

N'iji oge, enwere ike ịbawanye nsonaazụ nke ndị na - ekwupụta ọmịiko na akụrụngwa obi yana ịbawanye n'ihe ize ndụ nke ịmalite nsogbu gbasara obi, tachycardia, na ọbara mgbali elu.

N'iji ọgwụ ọgwụ antipsychotic (antipsychotics), na-egbochi ọgwụ metabolism ọnụ, ebe ụzọ maka ịdị njikere iwelatalata.

Site na iji otu oge na ndị na - eme ihe antihypertensive (ma e wezụga clonidine, guanethidine na usoro ha), ọ ga - ekwe omume ịbawanye mmetụta antihypertensive na ihe ize ndụ nke ịmalite hyporatụ orthostatic.

Iji otu oge na MAO inhibitors, mmepe nke nsogbu ọbara ọgbụgba ga-ekwe omume, yana clonidine, guanethidine - mbelata mmetụta hypotensive nke clonidine ma ọ bụ guanethidine ga-ekwe omume, yana barbiturates, carbamazepine - mbelata mmetụta nke amitriptyline n'ihi mmụba nke metabolism ya kwere omume.

A kọwara okwu ikpe gbasara mmepe nke ọrịa serotonin na iji otu oge eji sertraline.

N'iji ojiji nke ime ya eme ihe n’otu oge na ihe na - eme ka amitriptyline belata, nwere fluvoxamine, mkpokọta nke amitriptyline na plasma ọbara na ohere nke nsonaazụ mmụba na - abawanye, ya na fluoxetine, mkpokọta nke amitriptyline na plasma ọbara na-abawanye na mmeghachi nke nsi na-etolite n'ihi inhibine nke ọnya-ọnya-na-eji ọnya-na-enwe !!! amitriptyline metabolism, ya na cimetidine - ọ ga - ekwe omume ịkwụsịlata amitriptyline metabolism, mee ka itinye uche ya na plasma ọbara ma bulie t ksicheskih mmetụta.

N'iji oge ethanol eme ihe, ethanol na-abawanye uto, karie n’ime ụbọchị ole na ole mbụ ọgwụgwọ.

Ime na lactation

Ekwesighi iji Amitriptyline n'oge afọ ime, ọkachasị na oge ọkara nke I na III, belụsọ na ọnọdụ mberede. Emebeghị nnyocha ọmụmụ mara mma nke ọma na nchedo nke nchekwa amitriptyline n'oge afọ ime.

Ekwesịrị ka ejiri nwayọọ nwayọọ weghachite nnabata nke amitriptyline ma ọ dịkarịa ala izu asaa tupu amụọ nwa iji gbochie mmepe nke ọrịa nkwụchi na nwa amụrụ ọhụrụ.

N'ime ọmụmụ nnwale, amitriptyline nwere mmetụta teratogenic.

Contraindicated n'oge ara. Ọpịpịara ara ara nwere ike imebi ụra ụmụaka.

Analogs na ọnụ ahịa

"Amitriptyline Nycomed" (25 mg) na mbadamba nkume n'ụlọ ahịa ọgwụ na-efu ihe ruru 50-70 rubles kwa mkpọ. Ọzọkwa, ọgwụ dị n'ụdị ngwọta maka injection na infusion.

A na-emepụta Amitriptyline (25 mg) n'ụdị mbadamba ọtụtụ ụlọ ọrụ n'okpuru otu aha ahụ.

Yabụ, analogues nke ọgwụ sitere na ụlọ ọrụ ọgwụ "Nycomed" bụ ọgwụ sitere n'aka ndị nrụpụta:

Ọzọkwa, enwere ụdị dị ọnụ ala karịa maka imepụta ụlọ na mbadamba nkume akpọrọ "VERO-AMITRIPTILINE", nke ọtụtụ ụlọ ọrụ mba ofesi na-emepụta.

Amachibido iji

Na mgbakwunye na nnabata ọ bụla nke ọgwụ ahụ, amachibidoro iji:

• n’oge a na-eme ya na arara ura,
• ụmụaka na-erubeghị afọ isii
• n'oge mgbake mgbe nkụchi obi,
• ya na glaucoma n'akuku
• na-arịa ọrịa obi,

Amachibidoro ya iwu iwere "Amitriptyline", mmanya, psychotropic, analgesic na ọgwụ ịra ụra.

Nsonaazụ

Ebe ọ bụ na "Amitriptyline Nycomed" (25 mg), a kọwara ntuziaka maka ojiji dị ka ọgwụ mgbochi kachasị ike, ndepụta nke nsonaazụ ya na-achọghị. N'agbanyeghị nke a, dịka nyocha si kwuo, n'ọtụtụ ndị ọrịa ha anaghị eme ma ọlị ma ọ bụ naanị nkụchi na-apụta na ụbọchị mbụ mgbe ịmalite ọgwụgwọ.

Yabụ, ọgwụ nwere ike ibute ọgbaghara site na:

• sistemu ụjọ
• digestive
• obi
• endocrine
• hematopoietic.

Ọzọkwa, "Amitriptyline", ntụziaka ahụ nwere ndepụta zuru oke nke mmetụta ndị ọzọ, nwere ike ibute mmeghachi ahụ nfụkasị ahụ na anụ ahụ n'ụdị rashes, ọzịza ma ọ bụ itching. Na mgbakwunye, na ụfọdụ ndị ọrịa, ntutu isi, ọria aza, na tinnitus hụrụ n'oge ọmụmụ.

N'ime nsogbu ndị a na-ahụkarị, ndị ọrịa na-amata ihe ngosipụta nke njikwa anticholinergic. Ndị a gụnyere naanị nkụchi, akpọnwụ akpịrị, tachycardia, ọgba aghara, n'ọnọdụ ndị pụrụ iche enwere echiche.

Ọgba aghara nke usoro nri dịka ọgbụgbọ, ngbanwe n’echiche uto, ọgba aghara n’agụụ, obi mgbawa, stomatitis, afọ ọsịsa. O siri ike, ọrịa imeju na ịba ọcha n'anya na-apụta ìhè na ụzọ a.

Na akụkụ nke glandị gland, mmụba ara na ụmụ nwanyị na ịda ike nke ụmụ nwoke ka enwere ike ịhụ. Mmetụta a na-ahụkarị maka okike ọ bụla bụ mbelata libido. N'ime ọrụ nke obi, enwere ike igosipụta arrhythmias, tachycardia, dizziness, ndị na-enweghị atụ n'oge electrocardiogram na ndị ọzọ.

Ekwesịrị ịkwụ ụgwọ nlebara anya na ndepụta nke ngosipụta na-adịghị mma nke sistemụ ụjọ. N'agbanyeghị eziokwu ahụ bụ ọgwụ a ka akpadoro ya iji mee ka ọ kwụsie ike, ihe ka ọtụtụ n'ihe ọghọm dị na nsonaazụ ya sokwa ya.

Yabụ, ndị ọrịa nwere ike inweta:

• nchegbu
• iro ụra
• ụba ịda mba
• ịkụda mmụọ
• manic na-ekwu
• uche ya
• psychosis
• isi ọwụwa
• ehighi ura
• abalị na-arọ nrọ
• ịba ụba nke ọdịkwụkwụ.

Ọzọ aro

Ndị ọrịa na-aga n'ọgwụ Amitriptyline kwesịrị iburu n'uche na ihe na-arụ ọrụ nwere ike ibute ọgba aghara n'oge mgbanwe dị elu na ọnọdụ kwụ ọtọ, yabụ ị ga-ebili mgbe niile. Ọzọkwa, site na ogologo oge ọgwụgwọ yana ịkwụsị ọgwụgwọ, ọtụtụ na-amalite mgbaàmà ndọrọ ego.

Ebe ọgwụ a megidere ọgwụ ndị na-egbochi MAO, ha kwesịrị ịmalite usoro ọgwụgwọ tupu izu 2 ka ịkwụsị ọgwụ ndị ahụ dị n'elu.

Ekwesịrị ịdọ ndị dọkịta aka na ntị oge niile ị takingụ ọgwụ a, kpomkwem n'ihi na ọ na-enwe ike imetụta mmetụta nke ọgwụ ndị ọzọ. Ọ dịkwa mkpa iji wezuga otu oge nchịkwa na ephedrine, phenylephrine na ihe ndị yiri ya.

N'ime ndị ọrịa agadi, ọkachasị ndị na-ahụ izu ike ma na-enwe obere mmegharị, ọgwụ ahụ nwere ike ibute nnukwu mgbochi eriri afọ. A na-anabata mmetụta ọ bụla siri ike n'ahụ ahụ n'ụdị elektrotherapy naanị n'okpuru nlekọta ndị dọkịta.

Ogologo oge ị drugụ ọgwụ ahụ nwere ike ịkpasu ọdịdị nke caries na mkpa maka ị additionalụkwu riboflavin.

Ọ bụrụ na enyere onye ọrịa ahụ ọgwụ ị aụ ọgwụ kwa ụbọchị nke ihe karịrị 150 mg, mgbe ahụ ọ ga-abụ na itinye uche nke ihe ahụ n'ime ahụ ga-akpalite mmụba nke ihe ọdịdọ ahụ na ngosipụta doro anya nke ọrịa nkwarụ na mgbaàmà ndị ọzọ. Site n'iji ogologo oge, ọ dịkwa mkpa ịtụle na ndị ọrịa nwere ike ịnwe ụdị igbu onwe ha, ọkachasị na-akwụsị ọgwụ ahụ.

Ngwa n'okpuru ụfọdụ ọnọdụ

Na nwata, a na-eji ọgwụ ahụ eme ihe naanị site na afọ 6 dị ka ụdị mbadamba. A na-egbochi ọbụna mmachi mmiri ọgwụ mgbochi. Enwere ike iji ha maka ụmụaka naanị site na afọ 12.

N’ime afọ ime, a machibidoro ọgwụ a iwu, n’ihi na, dịka nyocha si kwuo, o nwere ike inwe mmetụta ọjọọ na mmepe nwa ebu n’afọ. A na-anabata ojiji nke ọgwụ a n'ọnọdụ dị ụkọ ma ọ bụ naanị na oge nke abụọ, ma ọ bụrụ na uru ahụ na-ekpuchi mmerụ ahụ ọ bụla. Ọ dịkwa mkpa ịkwụsị ọgwụ n'oge ka nwa ahụ wee ghara ibute ọrịa ndọrọpụ azụ mgbe amuchara nwa. Ekwesịrị ịkwụsị ọgwụ a dịkarịa ala izu asaa tupu ụbọchị ọmụmụ a tụrụ anya ya.

N'oge nri, "Amitriptyline Nycomed" ejighi ya ma ọlị, ebe ọ nwere ike ibute iro ụra na ihe riri ahụ na ụmụaka.

N'ime ndị ọrịa merela agadi, ọgwụ a na-ebute ọrịa mgbochi eriri afọ, nke a ga-ewepụ ewepụ ma ọ bụ site n'iji onye ọzọ dochie ọgwụ ahụ. Ọzọkwa n'oge agadi, enwere ike ịnwe ọgwụ psychose, nke na - emekarị mgbe ọ kwụsịrị ọgwụ ahụ n'abalị.

“Amitriptyline Nycomed” (25 mg) nyocha nke ndị ọrịa nwere ahụ ike na-anakọta. Ọtụtụ n'ime ndị a na-anara ọgwụ a nwere afọ ojuju kpamkpam n'ihi nsonaazụ ahụ ma mara na ọ bụ obere ntakịrị nsogbu n'oge usoro ọgwụgwọ. Ọnụ ego dị ala, nke dịịrị mmadụ ọ bụla, ka amachapụrụ n'etiti uru ọgwụ dị, ọkachasị mgbe ị na-atụle na usoro ọgwụgwọ ga-ewe ihe dị ka ọnwa ole na ole. Na mkpokọta, na-eburu n'uche ụfọdụ njirimara na-adịghị mma, mmadụ niile na-ekwupụta arụmọrụ ya. Ọgwụ ahụ na - enyere ndị ọrịa aka obere oge iji kpochapụ ọrịa uche siri ike ma weghachite ọ joyụ nke ndụ ọzọ.

N'etiti obere mbadamba nkume ndị ahụ, nyocha na-achọpụta mmetụta ndị ọ na-enwe. N'ezie, ọtụtụ na-egosi na ha na-agafe oge, ma n'ọnọdụ ụfọdụ, ọ bụghị otú a. Ọ bụrụ na onye ọrịa akwụsịghị imebi ọgwụ ndị ọzọ na-adịghị mma ị takingụ ọgwụ, mgbe ahụ ọ dị mkpa ịkpọtụrụ dọkịta ka o wee jiri ọgwụ ọzọ dochie ya.

N'ezie, nyocha ndị na-adịghị mma na-abụkarị nke ndị ahụ kpebiri iji ọgwụ ahụ n'onwe ha, n'ihi na a na-ere ya n'ejighị dọkịta. O sitere n ’usoro ezighi ezi gbakọọ na ha nwere nsogbu. Dika nyocha si n’aka ndi dibia, a gha apuru igosiputa ihe ojoo ojoo obula site n’iburu n'uche udiri aru ahu na udiri onye oria.

Mmechi

N'agbanyeghị eziokwu ahụ bụ na n'ụwa nke oge a, enwere ọnụọgụ ọgwụ dị iche iche maka nsogbu uche, agbanyeghị, ịkwesịrị ichebe onwe gị oge niile. Ejikwala ọrụ ọzọ, ma ọ bụrụ na ọ ga-ekwe omume, gbalịa mee njem karịa, na-aga ihe omume ọdịnala, ma soro ndị ị hụrụ n'anya na-anọ. Echefula banyere ụra dị mma. Naanị mgbe ahụ ị gaghị atụ egwu nkụda mmụọ ọ bụla.

Jiri n’oge ime na n’oge a na-enye nwa ara

Ime
Ihe omumu omumu egosiputala nsonaazụ na usoro onunu ogwu ugboro ugboro karie ọkọlọtọ mmadụ.
Ahụmahụ na-adakarị na amitriptyline n'oge afọ ime nwere oke.
Emebebeghị nchekwa nke amitriptyline n'oge afọ ime.
Achọtaghị Amitriptyline n’oge afọ ime, ọkachasị n’oge nke atọ na nke atọ, ọ gwụla ma uru a tụrụ anya ya na nne ya karịrị akarị na nwa ebu n’afọ.
Ọ bụrụ na ụmụ nwanyị dị ime jiri ọgwụ ahụ, ọ dị mkpa ịdọ aka ná ntị banyere ihe egwu dị ukwuu nke nnabata dị otú ahụ maka nwa ebu n’afọ, ọkachasị n’oge nke atọ nke afọ ime. Ojiji nke ọgwụ mgbochi tricyclic ọgwụ tricyclic dị ukwuu n'ime oge atọ nke afọ ime nwere ike ibute nsogbu akwara ozi na nwa amụrụ ọhụrụ.
Enwere nsogbu nke ịda ụra na ụmụ amụrụ ọhụrụ ndị nne ha na-eji northriptyline (metabolite nke amitriptyline) n'oge afọ ime, na-arịba ama banyere njide nke urinary.
Ara
Mgbe ị na-eji amitriptyline, ị ga-akwụsị ịfeụ ara. Amitriptyline na-abanye n’ime mmiri ara. Oke nsi mmiri ara ara / plasma bụ 0.4-1.5 n’ime ụmụ na-enye nwa ara. Mmeghachi omume a na-achịkwaghị achịkwa nwere ike ịme.

Usoro onunu ogwu na nhazi

Denye n'ime na-ata ata (ozugbo nri).
Ndị okenye
Ọgwụ nke mbụ kwa ụbọchị bụ 25-50 mg, kewara abụọ, ma ọ bụ dịka otu ọgwụ tupu ị lakpuo ụra. Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ọgwụ kwa ụbọchị ruo 200 mg.
Usoro ọgwụgwọ ha na-abụkarị ọnwa 6 ma ọ bụ karịa iji gbochie nlọghachi.
Ndị agadi
Ndị okenye na-aka emezi emezi ka m-anticholinergic na-achọghị ka amitriptyline. Ya mere, maka ha, usoro ọgwụgwọ akwadoro bụ 25-30 mg / ụbọchị., Na-abụkarị 1 oge kwa ụbọchị (n'abalị). Ekwesịrị ịbawanye mmụba n’usoro iji nwayọ, ụbọchị ọ bụla, rute, ma ọ bụrụ na ọ dị mkpa, usoro nke 50-100 mg / ụbọchị, ruo mgbe a ga-enweta azịza (mmetụta). Nyocha ọzọ dị mkpa tupu ịdee usoro ọgwụgwọ ọzọ.
Renrụ ọrụ na-arụ ọrụ na ụlọ
Na ọnụnọ nke akụrụngwa ezughi oke, enwere ike iji ọgwụ a mee ihe.
Ọrụ imeju na-arụ ọrụ
N'ime ndị ọrịa nwere oke ịba ọcha n'anya, a ga-ebelata ọgwụ amitriptyline.
Oge ọgwụgwọ
Mmetụta antidepressant na-apụtakarị mgbe izu 2-4 gasịrị.
Ọgwụ antidepressant bụ ihe mebiri emebi, yabụ kwesịrị ịdị ogologo oge, ọ na-abụkarị ọnwa 6 ma ọ bụ karịa, iji gbochie ịda mba ọzọ.
Kagbuo
Ekwesịrị ịkwụsị ọgwụ a nwayọ iji zere mmepe nke ọrịa "nkwụsị", dịka isi ọwụwa, ọgba aghara ụra, iwe na ahụike ahụike n'ozuzu. Ihe mgbaàmà ndị a abụghị ihe ịrịba ama nke ị dependụ ọgwụ.

Mmetụta akụkụ

Ihe kariri 50% nke ndị ọrịa na-anata ọgwụ Amitriptyline Nycomed nwere ike ịnwe otu ma ọ bụ karịa nke mmeghachi omume ọjọọ ndị a. Amitriptyline nwere ike ibute nsonaazụ ndị yiri nke ndị ọzọ na-akpata antidepressants tricyclic ọzọ.
Reactionsfọdụ n'ime mmeghachi omume ọjọọ ndị edepụtara n'okpuru, dị ka isi ọwụwa, ịma jijiji, ibelata oge nlebara anya, afọ ntachi, na njikwa mmekọahụ, nwekwara ike ịbụ ihe mgbaàmà nke ịda mbà n'obi, ha na-apụkarịkwa na ịda mbà n'obi dị ala.
A na-egosipụta ugboro ole mmetụta ndị ọ ga-arụ dị ka: oge ​​mgbe (> 1/10), ọtụtụ mgbe (> 1/100, 1/1000, 1/10 000, site na sistem cardio:
Ọtụtụ mgbe: palpitations na tachycardia, orthostatic hypotension.
Ọtụtụ mgbe: arrhythmia (gụnyere ọgba aghara na-ebugharị, ịgbatị oge nke QT), hypotension, AV ngọngọ, ngagharị ngagharị na ụkwụ nke ukwu nke Ya.
Ugboro ugboro: mmụba n'ọbara.
Oke: infarction myocardial.
Si ụjọ usoro:
Ọtụtụ mgbe: ogwuura ogwugwu (ike ura, udiri ihi ura), ujo, ujo, isi isi.
Ọtụtụ mgbe: mgbanyụ ntị na-ebelata, mgbakasị ahụ uto, paresthesia, mgbaàmà extrapyramidal: ataxia, akathisia, parkinsonism, mmeghachi omume dystonic, dardkinesia na-egbu egbu, na-egbu azụ okwu.
Ugboro ugboro: ogwe.
Site na urinary system:
Ọtụtụ mgbe: njigide urinary.
Na akpukpo ahu:
Ọtụtụ mgbe: hyperhidrosis.
Ugboro ugboro: ọnya aru, akpukpo aru nke aru aru, urticaria.
Oke: fotoensitivity, alopecia.
Si uche:
Ọtụtụ mgbe: mgbanyụ anya na-ebelata, ebe obibi na-anaghị emebi emebi (enwere ike ịchọ iko agụ n'oge ọgwụgwọ).
Ọtụtụ mgbe: mydriasis.
Ugboro ugboro: tinnitus, ụba intraocular mgbali.
Oke: ike nke ebe obibi, ihe ojoo nke glaucoma dị warara.
Nsogbu iche echiche:
Ọtụtụ mgbe: ihe mgbagwoju anya (mgbagwoju anya na ndi okenye agadi bu nchekari, nsogbu nke ihi ura, icheta nsogbu, ncheghari uche uche, echiche ndi ozo, iche echiche).
Ọtụtụ mgbe: ibelata nlebara anya.
Ugboro ugboro: ọgụgụ isi akwara, nsogbu manic, hypomania, mania, echiche nke ụjọ, ụjọ, ehighị ụra nke ọma.
Oke: ime ihe ike, isi nkpa (na ndi okenye), hallucinations (na ndi oria no na schizophrenia).
Ọ dịkarịghị: echiche igbu onwe ya, omume igbu onwe ya.
Site na akụkụ ahụ dị na hemopoietic:
Oke: mgbochi nke ụmị ọkpụkpụ, agranulocytosis, leukopenia, eosinophilia, thrombocytopenia.
Site na nri diges
Ọtụtụ mgbe: ọnụ akọrọ, afọ ntachi, ọgbụgbọ.
Ọtụtụ mgbe: chịngọm ọgbụgba, mbufụt nke oghere olu, ezé ire ere, imetụ ọkụ n’ime ọnụ.
Ugboro ugboro: afọ ọsịsa, vom, ire nke ire.
Oke: ahụ mkpọnwụ mkpọnwụ, akpụ akpụ parotid gland, cholestatic jaundice, ọrụ imeju na-egbu ya, ịba ọcha n'anya.
Ọrịa ndị a na-ahụkarị:
Ọtụtụ mgbe: adịghị ike.
Ugboro ugboro: ọzịza nke ihu.
Oke: ahu ọkụ.
Site n'akụkụ nke metabolism:
Ọtụtụ mgbe: ibu na-abawanye nri.
Oke: nri riri.
Ọ dịkarịghị: syndrome nke ezughi oke nke homonụ antidiuretic.
Site na usoro omumu:
Ọtụtụ mgbe: imebi ma obu juwanye na inwe nmekorita nwoke na nwanyi.
Ọtụtụ mgbe: n'ime ụmụ nwoke - enweghi ike, ire ere.
Oke: n'ime ụmụ nwoke - ejaculation, gynecomastia, na ụmụ nwanyị - galactorrhea, orgasm na-egbu oge, ida ikike iji nweta orgasm.
Nnyocha ụlọ nyocha:
Ọtụtụ mgbe: Mgbanwe ECG, ịgbatị oge nke QT, mgbasawanye nke usoro QRS.
Oke: ndaghari site na usoro nlele nke imeju, ụba ọrụ alkaline phosphatase, transaminases.
Nwepu akuko
Contkwụsị ọgwụgwọ ozugbo ejiri ya ogologo oge nwere ike ibute ọgbụgbọ, isi ọwụwa, na ọrịa.
Nkwụsị ị theụ ọgwụ jiri nwayọ nwee njikọ oge dị ka mgbakasị ahụ, iwe iwe, na ọgba aghara nrọ na ihi ụra n’ime izu abụọ mbụ nke mbelata dose.
N’oge na-adịghị anya, ikpe ndị metụtara ọnọdụ manic ma ọ bụ hypomania mere n’ime ụbọchị 2-7 mgbe ịkwụsị iji ọgwụgwọ ogologo oge jiri ọgwụ mgbochi tricyclic.