Ọgwụ ASK-Cardio: ntuziaka maka ojiji > Ọgwụgwọ na mgbochi

Ọgwụ Jụọ - Ọ bụ ọgwụ antiplatelet na - egbochi ịgbakọ nchịkọta platelet, nweekwa ọgwụ antipyretic, analgesic na anti-inflammatory. A machibidoro ịhapụ ọgbakọ ahụ ọbụna mgbe ị drugụsịrị ọgwụ na obere doses, mmetụta ahụ na-adịgide ruo ọtụtụ ụbọchị mgbe ị afterụsịrị otu ọgwụ. Mbadamba osisi a na-etinye n'ime mmiri bụ ụdị ọgwụ ọgwụ anaghị agbasa n'ime afọ, ma si otú ahụ ihe egwu nke kọntaktị acetylsalicylic acid na mucosa gastric na mmebi ya belata. Ndakpọ nke mbadamba na mwepụta nke ihe na-arụ ọrụ na-apụta naanị na gburugburu ebe duodenum.

Ihe ngosi maka ojiji:
Ọgwụ Jụọ iji belata ihe egwu:
- ọnwụ na ndị ọrịa nwere nnukwu nnwale myocardial infarction,
- ọnwụ n'ime ndị ọrịa nwesịrị infarction myocardial,
mwakpo ọgbụgba na-efe efe (TIA) na ọrịa strok na ndị ọrịa nwere TIA,
- oria na onwu ya na nti isi anaghi agha.
Ọgwụ Jụọ maka mgbochi:
- thrombosis na embolism mgbe akwara vaskụla (percutaneous transluminal catheter angioplasty (PTCA), carotid endarterectomy, coronary artery bypass grafting (CABG), arteriovenous shunting),
- ọgbụgba nke akwara nke ọkpọkọ na akwara umeji mgbe ọ gbasasịrị ogologo oge (arụ ọrụ ịwa ahụ),
- marcardial infarction na ndị ọrịa nwere nnukwu ihe ize ndụ nke ịmalite nsogbu ọrịa obi (ọrịa shuga, ọbara ọgbụgba na-achịkwa) na ndị mmadụ nwere ọtụtụ ihe ọghọm nke ọrịa obi (hyperlipidemia, oke ibu, ị smokingụ sịga, ịka nká, wdg).
Ọgwụ Jụọ maka igbochi oria obia.

Usezọ iji:
A na-edenyekarị ndị okenye 1-2 mbadamba 75 nke 75 mg ma ọ bụ mbadamba 1 nke 150 mg kwa ụbọchị n'oge nri ma ọ bụ mgbe nri gasịrị.

Ọgwụ Jụọ a ga-eji ntakịrị mmiri jupụta ya.
Site na mpecardial infarction na nso nso a ma ọ bụ maka ndị ọrịa nwere ụbụrụ myocardial infarction: nha mbụ saturating bụ 225-300 mg nke acetylsalicylic acid 1 kwa ụbọchị iji nweta mkpochapụ ngwa ngwa nke nchịkọta platelet. Enwere ike iji dolle nke 300 mg kwa ụbọchị maka obere oge dabere na ngosipụta ọgwụgwọ.
Mbadamba nkume enwere ike idozi maka ngwa ngwa ngwa.

Mmetụta ọghọm:
Site na eriri afọ, dyspepsia, epigastric mgbu na mgbu afọ ka a na-ahụ, n’ọnọdụ ụfọdụ - ọnya afọ nke eriri afọ, ngosipụta nke akwara nke mbuze na ọnya afọ nke eriri afọ, nke na-adịghị ahụkebe nwere ike ibute ọria eriri afọ na perforations na ihe kwekọrọ. ulo oru egosi.
N'ihi mmetụta antiplatelet na platelet, acetylsalicylic acid nwere ike ịbawanye ohere nke ọbara ọgbụgba. Ọbara dịka ọbara ọgbụgba dị n'ime ahụ, hematomas, ọbara ọgbụgba site na sistem mkpụrụ ndụ, imi, ọbara ọgbụgba, na-adịkarị obere ma ọ bụ nke ukwuu, ọbara ọgbụgba dị ka eriri afọ, ọbara ọgbụgba ụbụrụ (ọkachasị ndị ọrịa nwere oke ọbara na-achịkwaghị achịkwa na / ma ọ bụ n'otu oge. iji ihe ndị na-egbu egbu na-agwọ ọrịa), n'ọnọdụ ndị a na-adịghị ahụkebe, nwere ike ịnwe ndụ. Hemorrhages nwere ike ibute nnukwu ọrịa postemorrhagic anaemia / ụkọ erughi ala (n'ihi ihe a na-akpọ latent microbleeding) yana ngosipụta ụlọ nyocha ndị kwekọrọ na mgbaàmà nke ọrịa dịka asthenia, pallor nke anụ ahụ, hypoperfusion.
N'ime ndị ọrịa nwere mmụọ onwe ha na salicylates, mmeghachi ahụ anụ ahụ na-asọ oyi nwere ike ịmalite, gụnyere ihe mgbaàmà dịka ọnya, urticaria, edema, na itching. N'ebe ndị ọrịa nwere ọrịa ụkwara ume ọkụ, ọ ga-ekwe omume ịrị elu nke bronchospasm, mmeghachi omume nfụkasị site na nro ruo n'ọdịdị nwere ike imetụta anụ ahụ, akụkụ okuku ume, akụkụ eriri afọ na usoro akwara obi.

Achọpụtabeghị mmeghachi omume ọjọọ, gụnyere ọrịa anaphylactic. N’oge na-adịghị anya, ọdịda nke imeju na-adịte aka na-abawanye na mmịnye umeji.
A hụrụ uhere na tinnitus, nke nwere ike igosipụta ị anụbiga mmanya ókè.

Contraindications:
Ihe mgbochi igbochi iji ogwu Jụọ na-:
- Hypersensitivity na acetylsalicylic acid, salicylates ndị ọzọ ma ọ bụ akụrụngwa ọgwụ ọ bụla.
-Akpali ụkwara ume ọkụ kpatara site na akụkọ ntolite nke salicylates ma ọ bụ NSAIDs.
- Nnukwu ọnya ọgbụgba.
- Hemorrhagic diathesis.
- Nnukwu gbasara akụrụ odida.
- Oria imeju dara.
- Okpu obi ike.
- Nchikota ya na methotrexate na uzo 15 mg / izu ma obu karia.

Ime
Ọgwụ Jụọ enwere ike iji ya n’oge ime naanị mgbe ọgwụ ndị ọzọ anaghị arụ ọrụ.
Ojiji nke salicylates n'oge ọnwa atọ nke ịtụrụ ime n'ihe gbasara ọmụmụ ụfọdụ nke ọrịa na - enwetabeghị n'ihe ọghọm nke mmebi ọrịa agbụrụ (palatoschisis (cleft palate), ntụpọ obi). Agbanyeghị, iji ọgwụ ogologo oge na usoro ọgwụgwọ agafe agafe karịa 150 mg / ụbọchị, ihe ize ndụ a tụgharịrị dị ala: n'ihi ọmụmụ nke a mere na ndị di na nwunye ụmụ 32,000, enweghi mkpakọrịta n'etiti iji acetylsalicylic acid na mmụba nke mmerụ ọmụmụ.
Enwere ike iji salicylates na nkebi nke mbụ na nke abụọ n’ime afọ ime naanị mgbe ha nwetachara ihe ọghọm / uru uru ọ bara. Dika nbuputa mbu, na iji ogwu a ogologo oge, odi nkpa ka ịghara iwere acetylsalicylic acid na dose kariri 150 mg / ubochi.
N'ime oge atọ nke afọ ime, ị doụ ọgwụ salicylates dị elu (karịa 300 mg / ụbọchị) nwere ike ime ka ime ime mee ka à ga-asị na imebi ihe isi ike n’oge ịmụ nwa, ọ nwekwara ike ibute nsí na cardiopulmonary (oge mmechi nke ductus arteriosus) na ụmụaka.
Ojiji nke acetylsalicylic acid n’ime nnukwu usoro obere oge tupu ọmụmụ nwa nwere ike ibute ọbara ọgbụgba n’ime intracranial, ọkachasị n’ebe akụrụ.

Yabụ, ewezuga maka okwu ndị pụrụiche akọwara site na ngosipụta akwara obi ma ọ bụ nke ịtụrụ ime na-esite na nlezianya pụrụ iche, ojiji nke Acetylsalicylic acid n'oge ọnwa atọ ikpeazụ nke afọ ime abaghị uru.
Acetylsalicylic acid na metabolites ya na obere ihe dị na mmiri ara ehi nke ụmụ nwanyị na-enye nwa ara. Ruo ugbu a, site na iji obere oge nke ndị nne na-eji salicylates emezi, mmalite nke mmetụta ndị na-adịghị mma n'etiti ụmụaka na-enye nwa ara, dịka iwu, ọ dịghị mkpa ịkwụsị ị -ụ ara. Agbanyeghị, ọ bụrụ na ị jiri ọgwụ Acetylsalicylic acid dị ogologo oge, a ga-akwụsị ịhapụ inye ara ya.

Mmekọrịta na ọgwụ ndị ọzọ:
Ojiji nke acetylsalicylic acid na methotrexate na usoro nke 15 mg / izu na ihe ndị ọzọ na - egbochi n'ihi mmụba na-egbu egbu nke methotrexate (belata mkpochapu mkpoku nke methotrexate na ndị na-emegide mkpali na ịchụpụ nke methotrexate na salicylates n'ihi nchebe nke plasma).
Ejikọtara ọnụ iji kpachara anya:
- iji ya na methotrexate na usoro onunu erughị 15 mg / izu na-abawanye hematological toxicity nke methotrexate (mbelata na mkpochapụ mkpụkọ nke methotrexate ya na ndị na - emegide mbuze na mbupụ nke methotrexate na salicylates site na mkpakọrịta na protein protein.
- oge nke ibuprofen na - egbochi mgbochi a na - agbanweghi agbanwe nke platelet site na acetylsalicylic acid. Ọgwụ Ibuprofen maka ndị ọrịa nọ n'ihe ize ndụ nke ọrịa obi nwere ike igbochi mmetụta cardioprotective acid na acetylsalicylic acid.
- iji otu ọgwụ na anticoagulants n’otu oge, ohere nke ọbara ọgbụgba na-abawanye. N'iji oge nke iji salbilelates dị elu na NSAIDs (n'ihi mmetụta ndị ọzọ nwechara), ihe egwu ọnya na ọbara ọgbụgba na-abawanye.
- iji ya eme ihe n'otu oge ya na ndi uricosuric, dika benzobromaron, probenecid, na --ebelata ihe a na - agha uric acid excretion (n'ihi asọmpi maka iwepụ uric acid site na teliles renal).
- jiri iji digoxin mee ihe n'otu oge, itinye uche nke ikpeazụ na plasma ọbara na-abawanye n'ihi mbelata nke mkpịpụrụ akwara.
- site na iji oge nke oke onunu ogwu acetylsalicylic acid na ọgwụ antidiabetic nke sitere na otu nke sulfonylurea ma ọ bụ ọgwụ insulin, a na-akwalite mmetụta hypoglycemic nke ikpeazụ n'ihi mmetụta hypoglycemic nke acetylsalicylic acid na nchụpụ nke sulfonylurea metụtara protein amị.
- diuretics yana otutu acetylsalicylic acid belatara mmụba glomerular n'ihi mbelata nsụkọta nke prostaglandin na akụrụ.
- systemic glucocorticosteroids (ewezuga hydrocortisone) eji maka ọgwụgwọ ọgwụgwọ maka ọrịa Addison n'oge ọgwụgwọ corticosteroids belatara ọkwa nke salicylates n'ọbara ma bulie ohere nke ịdoụbiga mmanya ókè mgbe ọgwụgwọ gasịrị.

Mgbe eji corticosteroids, nsogbu nke ibute ọbara ga-abawanye.
- nhọrọ nke serotonin reuptake inhibitors: ịba ụba nke ọbara ọgbụgba site na eriri afọ dị elu n'ihi ohere nke ọgbụgba synergistic.
- ACE inhibitors (ACE) na otutu nke acetylsalicylic acid na - akpata mbelata nke nzacha zuru ụwa ọnụ n'ihi mgbochi nke vasodilator prostaglandins na mbelata na mmetụta antihypertensive.
- iji otu ihe a na - eme ya na valproic acid, acetylsalicylic acid na - egbochi ya na njikọ ya na protein protein, na - abawanye nsị nke ikpeazụ.
Mmanya Ethyl na-enye aka na mmebi nke akpụkpọ ahụ mucous nke eriri afọ ma na-agbatị oge ọbara ọgbụgba n'ihi mmekọrịta nke acetylsalicylic acid na mmanya.

Dodoụbiga ya ókè
Icydoụbiga mmanya ókè ókè ga-ekwe omume n’ihi ịxụbiga mmanya ókè nke bilitere n'ihi ọgwụgwọ ogologo oge, yana ịuteụbiga mmanya ókè, nke na-eyi ndụ egwu (ịdoụbiga ya ókè), na ihe kpatara ya nwere ike ịbụ, dịka ọmụmaatụ, iji ụmụaka mee ihe na mberede ma ọ bụ ịdoụbiga mmanya ókè.
Ihe mgbaàmà mbụ nke ịxụbiga mmanya ókè na acetylsalicylic acid bụ ọgbụgbọ, ọgbụgbọ, ọgbụgbọ, tinnitus na iku ume ngwa ngwa, enweghị ike. Achọpụtagokwa ihe mgbaàmà ndị ọzọ: nhụju anya, nkwarụ anya, isi ọwụwa, ịsụsọ na-aba ụba, mgbali moto, ụra na coma, ahụ mgbu, ọbara mgbali elu, ọgba aghara. A pụrụ izochi nsị nke salicylate, n'ihi na ihe ịrịba ama ya na ihe mgbaàmà ya enweghị atụ.
Bụrụ na ị takingụ ọgwụ dị ukwuu karịa nke a tụrụ aro, ị ga-agakwuru dọkịta ozugbo, ma ọ bụrụ na ị nwere nnukwu nsị ị ga-aga ụlọ ọgwụ ozugbo.
Doụ ọgwụ ahụ ókè n'ahụ ndị ọrịa agadi na obere ụmụaka (ị largerụ nnukwu ọgwụ a tụrụ aro ma ọ bụ nsị na mberede) chọrọ nlebara anya pụrụ iche, ebe ọ bụ na n'ime ìgwè ndị ọrịa a nwere ike ịkpata ọnwụ.
Na mmenaanya siri ike, nguzogide acid na mmiri mmiri electrolyte na-enye nsogbu (metabolic acidosis na mmiri mmiri).
Enweghị ọgwụ mgbochi akọwapụtara.

Ọnọdụ nchekwa:
Chekwaa ya n’ebe ebe anabataghi ya ma kpo oku n’omume na erughi 25 Celsius.
Ekwela ka ụmụaka ghara iru ya.

Mwepụta weputara:
ASA - mbadamba mkpụrụ osisi, 75 mg na 150 mg.
Mbubata: mbadamba 10 ma ọ bụ 15 na blisters. Mpempe atọ, ise ma ọ bụ isii nke mbadamba 10, ọ bụla yana ntuziaka maka iji ya na otu kaadiboodu.
Mpempe 6 na-acha uhie uhie nke mbadamba 15, yana ntuziaka maka iji ya na otu kaadiboodu.

Ngwakọta:
1 mbadambaJụọ nwere ihe eji arụ ọrụ: acetylsalicylic acid - 75 mg ma ọ bụ 150 mg.
Ndị ọkachamara: stachi ọka, crospovidone (polyplasdone XL-10), talc, celclose microcrystalline.
Ihe mejupụtara Shell: Advant Preferred (hydroxypropyl methylcellulose, copovidone, polydextrose, propylene glycol, ọkara silsila triglycerides, titanium dioxide, iron ironide), Advantia Performance® (methaclates acid-ethyl acrylate copolymer, talc, titanium dioxide, oroma edo edo. , na-adọrọ adọrọ uhie E 129).

Nhọrọ:
Ọgwụ Jụọ ejiri nlezianya mee ihe maka: hypersensitivity na analgesic, anti-inflammatory, anti-rheumatic ọgwụ, yana ọnụnọ nke nfụkasị ihe ndị ọzọ, ọnya nke eriri afọ, gụnyere akụkọ banyere ọrịa ọgbụgba na-alaghachi ma ọ bụ mgbatị afọ, otu oge iji anticoagulants, na-arụ ọrụ na-arụ ọrụ na-arụ ọrụ akụrụngwa na / ma obu imeju.
N'ihe banyere ị prolongụ ọgwụ ogologo oge, onye ọrịa ahụ kwesịrị ịkpọtụrụ dọkịta tupu ya ewere ibuprofen.
N'ime ndị ọrịa nwere nsogbu ahụike, gụnyere ụkwara ume ọkụ, rhinitis nfụkasị, urticaria, itching skin, swip nke mucous membrane na nasal polyposis, yana njikọta na ọrịa ọrịa na-adịghị ala ala na ndị ọrịa nwere NSAIDs ejiri ọgwụgwọ acetylsalicylic acid gwọọ ya. ikekwe mmepe nke akwara ozi ma ọ bụ ọgụ ụkwara ume ọkụ. N'ime ọrụ ịwa ahụ (gụnyere eze), iji nkwadebe nwere acetylsalicylic acid nwere ike ime ka ọbara ọgbụgba dịkwuo elu. N'inye obere ogwu acetylsalicylic acid, enwere ike belata ike uric acid excretion. Nke a nwere ike ibute gout na ndị ọrịa nwere mgbada ikuku uric acid belatara.
N'oge ọgwụgwọ acetylsalicylic acid ekwesịghị ị alcoholụ mmanya, nyekwuru ihe ọghọm nke mbibi akpụkpọ ahụ mucous nke eriri afọ.
Ejila ọgwụ ogwu nke nwere acetylsalicylic acid maka ụmụaka nwere nnukwu akụkụ iku ume iku ume (ARVI), nke mmụba nke okpomoku na-esonye ma ọ bụ na-esoghị. Maka ụfọdụ ọrịa malitere ịrịa, ọkachasị influenza A, influenza B na chickenpox, enwere ihe ọghọm nke ibute ọrịa Reye, nke bụ oria a na-adịghị ahụkebe mana nke na-egbu ndụ nke chọrọ nlekọta ahụike ngwa ngwa. Enwere ike ịbawanye ihe egwu ahụ ma ọ bụrụ na ejiri acetylsalicylic acid mee ihe dị ka ọgwụ ejikọtara ọnụ, mana egosighi mmekọrịta dị na nke a. Ọ bụrụ na ọnọdụ ndị a sochiri ọgbụgbọ ogologo oge, nke a nwere ike ịbụ akara nke Reye's syndrome. N'iburu n'uche ebumnuche ndị a dị n'elu, ụmụaka na-erubeghị afọ 16 na-egbochi ọgwụ ahụ na-enweghị ihe ngosi pụrụ iche (ọrịa Kawasaki).
Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa
ASA anaghị emetụta ikike ịkwọ ụgbọala na usoro njikwa.

Mwepụta wepụtara ya na ihe mebere

ASK-kaadi dị n'ụdị mbadamba ụrọ gbara agba: biconvex, okirikiri, ọcha (iberibe iri na blisters, na ngwungwu kaadiboodu nke 1, 2, 3, 5, 6 ma ọ bụ 10, 30, 50, 60 ma ọ bụ 10). Mbadamba 100 na mbadamba polymer, na na kaadiboodu 1 nwere ike).

Ngwakọta 1 mbadamba:

ihe na-arụ ọrụ: acetylsalicylic acid (ASA) - 100 mg,
ihe inyeaka: stachi nduku, stearic acid, lactose monohydrate, talc, polyvinylpyrrolidone,
mkpuchi mkpụrụ osisi: macrogol 6000, titanium dioxide, talc, copolymer nke methaclates acid na ethacrylate.

Ihe ngosi maka ojiji

angina enweghi ike,
igbochi ihe ọghọm ụbụrụ ụbụrụ,
igbochi thromboembolism nke akụkụ akwara umeji na alaka ya, yana ụkwara ume ala ala (dịka ọmụmaatụ, na enweghi ike ịnọ ogologo oge n'ihi nnukwu ịwa ahụ)
Mgbu ọrịa strok (gụnyere na ndị ọrịa nwere ọrịa ọrịa ụkwara ume ọkụ),,
mgbochi nke nnukwu myocardial infarction na ihe otu ma ọ bụ karịa ihe egwu (ọbara mgbali, ọrịa shuga, oke ibu, hyperlipidemia, agadi, ị smokingụ sịga), mgbochi nke ugboro ugboro infarction myocardial,
mgbochi nke thromboembolism mgbe ọ wakpo na ịwa ahụ (dịka ọmụmaatụ arteriovenous bypass surgery, akwara akwara akwara grafoning, carotid artery angioplasty, carotid artery endarterectomy).

Ihe ngbanwe

nnukwu ikeji imeju
nnukwu nsogbu gbasara akwara
hemorrhagic diathesis (ọrịa ọrịa Willebrand, hypoproteinemia, thrombocytopenic purpura, hemophilia, telangiectasia, thrombocytopenia),
okpukpo obi na-adịghị ala ala nke III-IV,
eriri afọ,
iwe iwe na ọnya afọ nke eriri afọ,
ụkọ lactase, nnagide nri nke lactose, ọrịa glucose-galactose malabsorption,
Ahịhịa ụkwara ume na-esite na iji ọgwụ mgbochi mkpali na steroidal na salicylates, njikọta nke polyposis na-eme ugboro ugboro nke sinetal sinuses na imi, ụkwara ume ọkụ na ịba ọcha n'anya nke ASA,
oge ime ha (nke mbụ na nke atọ),
oge inye ara,
ụmụaka na ndị na-eto eto nọ n’agbata afọ 18,
iji conhoitọtụ na-eme ihe na kwa izu nke 15 mg ma ọ bụ karịa,
mụbara ọgụgụ mmadụ n'otu n'otu na ọgwụ nke ọgwụ ndị ọzọ anaghị alụ ọgụ.

E jiri mkpachapụ anya mee ihe (ASK-cardio)

nwayọ nke afọ na-adị nke imeju,
obere ọdịda akụrụngwa ọdịda,
ọrịa na-efe efe na-adịghị ala ala,
ụkwara ume ọkụ,
Akụkọ gbasara ọbara ọgbụgba ma ọ bụ ọnya afọ,
polyposis nke imi,
hay fever
hyperuricemia
gout
Enweghị vitamin K
ọgwụ ịgwọ ọrịa
ụkọ glucose-6-phosphate dehydrogenase,
oge ime (ọnwa nke abụọ),
ịwa ahụ n’ihu
n'otu oge iji ụfọdụ ọgwụ (ya na antiplatelet, anticoagulant, ma ọ bụ ndị nnọchi ọgwụ thrombolytic, ibuprofen, digoxin, methotrexate (na izu ụka erughị 15 mg), valproic acid, nhọrọ serotonin reuptake inhibitors, a na-ahọrọ ọgwụ salicylic acid, maka usoro ọgwụgwọ dị elu) nchịkwa ọnụ na insulin, ọgwụ mgbochi mkpali na-enweghị steroidal na mmanya).

Usoro onunu ogwu na nhazi

A na-ewere ọnụ ASA cardio mgbe nri gasịrị. A naghị ata ata mbadamba nkume ahụ, were nnukwu mmiri mmiri sachaa ya.

Ọ bụ dibia bekee gara kpebie oge ọgwụgwọ ahụ. Dịka onye nnọchi anya nke antiplatelet, a na-a drugụ ọgwụ ahụ ogologo oge.

Usoro a tụrụ aro:

mgbochi nke nnukwu myocardial infarction (ọ bụrụ na a na-enyo enyo na ọ na-etolite ya): ọgwụ mbụ bụ 100-300 mg, ekwesịrị ị drugụ ọgwụ ahụ ozugbo enwere ike mgbe enyochara nke mmepe nke nnukwu myocardial infarction pụtara (maka nnabata ngwa ngwa, mbadamba mbụ nke ọgwụ ahụ ga-ata ata). Ọgwụ mmezi mgbe mmepe nke infarction myocardial bụ 200-300 mg kwa ụbọchị maka ụbọchị 30,
mgbochi nke nnukwu myocardial infarction nke bilitere na nke mbụ (na ọnụnọ nke ihe ọghọm): 100 mg otu ugboro kwa ụbọchị ma ọ bụ 300 mg kwa ụbọchị,
mgbochi nke ụkwara ume ọkụ na alaka ya, yana ụkwara ume ala: 100-200 mg kwa ụbọchị ma ọ bụ 300 mg kwa ụbọchị,
ihe ngosi ndi ozo: 100-300 mg kwa ubochi.

Nsonaazụ

usoro nri: otutu oge - ọgbụgbọ, ọgbụgbọ, ihe mgbu nke afọ, obi mgbawa, adịkarịghị - ọbara ọgbụgba site na eriri afọ, ọnya afọ na afọ (gụnyere akpụ akpụ), ịba ụba ọrụ nke mbufụt hepatic (obere oge),
sistem: obi ukwu - iguzo ukwu ala, ubara ihe mgbawa nke obi daa ala,
sistem ọbara ọgbụgba: intra- na postoperative, ọbara ọgbụgba, hematomas, ọbara ọgbụgba site na mkpụrụedemede mkpụrụ ndụ, imi afọ, ọbara ọgbụgba n'ime ụbụrụ, oke ma ọ bụ ọrịa postemorrhagic / ụkwara erughi ala, na ndị ọrịa nwere oke glucose-6-phosphate dehydrogenase ụkọ na hemolysis
sistemụ akwara ndị dị n’ime ala: tinnitus, ọnwụ ịnụ, ọgbụgba,
Usoro urinary: arụ ọrụ ezughi oke ọrụ, nnukwu akụrụ oke,
Mmeghachi omume nfụkasị: bronchospasm, itching na ihe ngbu, rhinitis, urticaria, cardio-respiratory depression syndrome, ọnya Quincke, ọrịra nke mualsa imi, ujo anafilactic.

Ntụziaka pụrụ iche

A ga-eji ọgwụ ASK-cardio mee ihe naanị ka dọkịta nyere ya aka.

N'ihe dị ala, ASA nwere ike ibute gout na ndị ọrịa nwere nsogbu.

Ọgwụ dị elu nke ọgwụ nwere mmetụta hypoglycemic, nke ekwesịrị ịtụle mgbe ị na-edebanye ASA ka ndị ọrịa nwere ọrịa mellitus na-anata insulin ma ọ bụ ọgwụ hypoglycemic ọgwụ.

Ọ bụrụ na ọnụego ASK-cardio karịrị akarị, ọghọm nke ibute ọbara na-abawanye.

N'ime ndị ọrịa meworo agadi, ịdoụ ọgwụ gabigara ókè dị ize ndụ karịsịa.

N'oge ọgwụgwọ, ekwesịrị ilezi anya mgbe ị na-arụ ọrụ metụtara ntinye uche dị ukwuu na mmeghachi omume ngwa ngwa (ịkwọ ụgbọ ala, ọrụ onye ọrụ na onye na-ezipụ ya, wdg).

Mkparịta ụka ọgwụ ọjọọ

Site n'iji ASA-cardio na-eme ihe n'otu oge, ọ na-akwalite mmetụta ọgwụgwọ na mmetụta dị n'akụkụ ọgwụ ndị na-eso: methotrexate, thrombolytic, antiplatelet na ndị na-anticoagulant, serotonin reuptake inhibitors, digoxin, insulin na ọnụ hypoglycemic waki, valproic acid, salicylidos . Ọ bụrụ na ọ dị mkpa iji ASA otu oge na ọgwụ ndị edepụtara, a na-atụ aro ịtụle belata usoro onunu ogwu ha.

Mgbe ejikọtara ya na oke ọnụọgụ, ASA-cardio na-ebelata ike ọgwụgwọ nke ọgwụ ndị na-esote: diuretics, angiotensin-inhibing enzyme inhibitors, uricosuric jami (probenecid, benzbromarone), sistemụ glucococorticosteroids (ma e wezụga hydrocortisone, eji maka ọgwụgwọ ọgwụgwọ nke ọrịa Addison). Ọ bụrụ na ọ dị mkpa iji ASA yana ọgwụ ndị edepụtara, a na-atụ aro ịtụle okwu banyere idozi dose.

Nkwadebe acetylsalicylic acid ndị ọzọ

Usoro onunu ogwu na nhazi

A na-ewere ọnụ ASA cardio mgbe nri gasịrị. A naghị ata ata mbadamba nkume ahụ, were nnukwu mmiri mmiri sachaa ya.

Ọ bụ dibia bekee gara kpebie oge ọgwụgwọ ahụ. Dịka onye nnọchi anya nke antiplatelet, a na-a drugụ ọgwụ ahụ ogologo oge.

Usoro a tụrụ aro:

mgbochi nke nnukwu myocardial infarction (ọ bụrụ na a na-enyo enyo na ọ na-etolite ya): ọgwụ mbụ bụ 100-300 mg, ekwesịrị ị drugụ ọgwụ ahụ ozugbo enwere ike mgbe enyochara nke mmepe nke nnukwu myocardial infarction pụtara (maka nnabata ngwa ngwa, mbadamba mbụ nke ọgwụ ahụ ga-ata ata). Ọgwụ mmezi mgbe mmepe nke infarction myocardial bụ 200-300 mg kwa ụbọchị maka ụbọchị 30,
mgbochi nke nnukwu myocardial infarction nke bilitere na nke mbụ (na ọnụnọ nke ihe ọghọm): 100 mg otu ugboro kwa ụbọchị ma ọ bụ 300 mg kwa ụbọchị,
mgbochi nke ụkwara ume ọkụ na alaka ya, yana ụkwara ume ala: 100-200 mg kwa ụbọchị ma ọ bụ 300 mg kwa ụbọchị,
ihe ngosi ndi ozo: 100-300 mg kwa ubochi.

Anaghị akwụsị akwụsị angina,
igbochi ihe ọghọm ụbụrụ ụbụrụ,
igbochi thromboembolism nke akụkụ akwara umeji na alaka ya, yana ụkwara ume ala nke ukwuu (dịka ọmụmaatụ, na enweghi ike ịnọ ogologo oge n'ihi oke ịwa ahụ),
Mgbu ọrịa strok (gụnyere na ndị ọrịa nwere ọrịa ọrịa ụkwara ume ọkụ),,
mgbochi nke nnukwu myocardial infarction na ihe otu ma ọ bụ karịa ihe egwu (ọbara mgbali, ọrịa shuga, oke ibu, hyperlipidemia, agadi, ị smokingụ sịga), mgbochi nke ugboro ugboro infarction myocardial,
mgbochi nke thromboembolism mgbe ọ wakpo na ịwa ahụ (dịka ọmụmaatụ arteriovenous bypass surgery, akwara akwara akwara grafoning, carotid artery angioplasty, carotid artery endarterectomy).

Mmetụta akụkụ

Usoro nri: ọtụtụ mgbe - ọgbụgbọ, ọgbụgbọ, mgbu n'ime afọ, obi mgbawa, adịghị obere - na-agba ọbara site na eriri afọ, ọnya duodenal na afọ (gụnyere nke zuru oke), ịba ụba ọrụ nke transpakere hepatic (obere oge).

Ọkpụkpụ akụrụngwa: adịghị ike - ọzịza nke ukwu, ịba ụba nke ihe mgbawa nke obi na-adịghị ala ala.

Usoro nke Hematopoietic: intra- na postoperative ọbara ọgbụgba, goms ọbara ọgbụgba, hematomas, ọbara ọgbụgba si genitourinary traktị, imi afọ, hemorrhages na ụbụrụ, nnukwu ma ọ bụ na-adịghị ala ala post-hemorrhagic / iron እጥረት anaemia, na ndị ọrịa nwere oké glucose-6-phosphate dehydrogenase erughi - hemolytic anaemia na.

Sistemụ akwara Central: tinnitus, ịnụ ntị, dizziness.

Usoro ure: arụ ọrụ ezughi oke ọrụ, nnukwu akụrụ nke ọdịda.

Mmeghachi omume nfụkasị ahụ: bronchospasm, isi ọwụwa na ihe ngbu, rhinitis, urticaria, cardio-respiratory depression syndrome, ọnya Quincke, ọrịra nke mualsa imi, ujo anafilactic.

Dodoụbiga ya ókè

Ihe mgbaàmà nke oke ịba oke: ọgbụgbọ, ọgbụgbọ, tinnitus, ịnụ ntị, ọgbụgba, ọgba aghara.
Ọgwụ: Mbelata dose.

Mgbaàmà nke oke nnyeferena: ahụ ọkụ, hyperventilation, ketoacidosis, alka iku ume, coma, akwara obi na okuku ume, oke hypoglycemia.
Ọgwụ: ime ụlọ ọgwụ ozugbo na ngalaba ndị pụrụ iche maka ọgwụgwọ mberede - lavage gastric, mkpebi siri ike nke acid-base, alkaline na mmanu alkaline diuresis, ịba ọcha n'anya, nchịkwa nke ihe ngwọta, unyi arụ ọrụ, unyi na-agwọ ọrịa.

Cesssesụfe oke ogwu nke ASA nwere ihe ọghọm nke ọbara ọgbụgba. Do Overụbiga mmanya ókè dịkarịsịrị ize ndụ na ndị ọrịa merela agadi.

Nchikota kwa otu mbadamba 1:

ike ọrụ: Acetylsalicylic acid 100 mg,
ndị na-ebu ụzọ:
isi: lactose monohydrate (shuga mmiri ara ehi) 15.87 mg, povidone (polyvinyl pyrrolidone) 0.16 mg, stachi 3.57 mg, talc 0.2 mg, stearic acid 0.2 mg
shei: methaclates acid na ethacrylate copolymer 1: 1 (colicoate MAE 100) 4.186 mg, macrogol-6000 (polyethylene glycol dị elu nke kwayoyin) 0.558 mg, talc 1.117 mg, titanium dioxide 0.139 mg.

mbadamba biconvex gbara okirikiri, nke a na-eji mkpuchi ọcha. Akụkụ obe nke isi bụ ọcha.

Otu na-ere ọgwụ:

Mlọ ọgwụ
Acetylsalicylic acid (ASA) bụ ester nke salicylic acid, bụ nke otu ọgwụ ọgwụ anti-inflammatory (NSAIDs) abụghị ọgwụ steroidal. Usoro nke usoro a dabere na irighiri akabeghị enzyme cyclooxygenase (COX-1), n'ihi nke a na - egbochi mkpọchi prostaglandins, prostacyclins na thromboxane. Na-ebelata nchịkọta, platelet na intrombosis site na igbochi njikọta nke thromboxane A₂ na platelet. Ọ na - eme ka fibrinolytic na - arụ ọrụ nke plasma ọbara ma belata ntinye uche nke coagulation vitamin K (II, VII, IX, X). Mmetụta antiplatelet na-etolite mgbe ejiri obere ọgwụ were ya wee dịgide ruo ụbọchị 7 mgbe otu mmachara. A na-eji ihe ndị a ASA mee ihe na igbochi na ọgwụgwọ nke infarction myocardial, ọrịa obi na akwara, nsogbu nke veins varicose. ASA na usoro onunu ogwu (ihe kariri 300 mg) nwere mgbochi oria, antipyretic na mmetụta analgesic.

Mlọ ọgwụ
Mgbe nchịkwa ọnụ gachara, ASA na-agbakọta ngwa ngwa ma zuo ezu site na eriri afọ (GIT). ASA nwere obere metabolized n'oge a na-eme ka mmiri. N'oge na mgbe a gbasịrị, ASA na-agbanwe n'ime metabolite bụ isi - salicylic acid, nke metabolized kachasị na imeju n'okpuru enzymes na nguzobe metabolites dịka phenyl salicylate, glucuronide salicylate na salicyluric acid, nke a na-ahụ n'ọtụtụ akwara na mmamịrị. N’ime ụmụ nwanyị, usoro metabolic dị nwayọ (ọrụ pere mpe nke enzymes n’ọbara ọbara). A na-enweta ntinye uche kachasị elu nke ASA na plasma ọbara 10-20 nkeji mgbe mmesịrị, salicylic acid - mgbe awa 0.3-2 gasịrị. N'ihi eziokwu ahụ na mbadamba ndị ahụ nwere ihe mkpuchi na-egbochi acid, a na-ahapụ ASA na afọ (mkpuchi ahụ na-egbochi mgbasa nke ọgwụ na afọ), mana gburugburu alkaline nke duodenum. Ya mere, nnabata nke ASA na usoro onodu ogwu, mbadamba ihe eji eme ihe, ihe eji eme ihe nkiri, a na-egbu oge awa 3-6 ma e jiri ya na mbadamba udiri emeghe.
ASA na salicylic acid na-ejikọ protein protein plasma (site na 66% ruo 98% dabere na dose) ma kesaa ngwa ngwa na ahụ. Salicylic acid na-agafere Plasenta ma mmiri ara ehi kpuchie ya.
Nsonye nke salicylic acid bu ihe dabere na ogwu, ebe ike ya sitere na ikike nke usoro enzymatic. Ọkara ndụ ahụ sitere na awa 2-3 mgbe ị na-eji ASA na usoro dị ala yana ruo awa 15 mgbe ị na-eji ọgwụ ahụ na oke doses (usoro ọgwụgwọ acetylsalicylic acid nkịtị dị ka analgesic). N’adịghị ka ọgwụ ndị ọzọ na-eme ka ọgwụ ndị ọzọ dị, yana iji ọgwụ ugboro ugboro, ASA na-enweghị mmiri adịghị agbakọ n'ọbara ọbara. Salicylic acid na metabolites ya bụ akụrụ. N'ime ndị ọrịa nwere ọrụ akụrụngwa nkịtị, akụrụ wepụrụ pasent 80-100 nke otu ọgwụ n'ime awa 24-72.

Ihe ngosi maka ojiji

angina enweghi ike,
angina kwụsiri,
mgbochi nke nnukwu myocardial infarction na ọnụnọ ihe ndị dị ize ndụ (dịka ọmụmaatụ, ọrịa shuga shuga, hyperlipidemia, ọbara mgbali elu, oke ibu, ị smokingụ sịga, ịka nká) na infarction myocardial,
igbochi ọnya afọ ischemic (gụnyere n'ime ndị ọrịa nwere ọrịa ọgaghị adị),,
igbochi ihe ọghọm ụbụrụ ụbụrụ,
mgbochi nke thromboembolism mgbe ịwa ahụ na ọgwụ ndị na - emetụta akwara (dịka ọmụmaatụ akwara ọbara na - esochi grafting, carotid artery endarterectomy, arteriovenous shunting, carotid artery angioplasty),
mgbochi nke thrombosis nke miri emi na thromboembolism nke akụkụ akwara umeji yana alaka ya (dịka ọmụmaatụ, ya na ịgbatị ogologo oge n'ihi oke ịwa ahụ).

Jiri n’oge ime na n’oge a na-enye nwa ara

A na - egbochi ọgwụ a n'oge ime (M na III trimesters) yana n'oge a na-enye nwa ara. Ojiji nke salicylates dị ukwuu n'ime ọnwa atọ mbụ nke ịtụrụ ime jikọtara ya na oke mmụba nke nsogbu nke nwa ebu n’afọ (oke na oke, obi obi). N'ime oge nke abụọ nke afọ ime, a ga-enye salilylates naanị na nyocha dị omimi banyere ihe ọghọm na uru.
Na ngwụcha ọnwa atọ nke ịtụrụ ime, salicylates na oke ọgwụ (ihe karịrị 300 mg / ụbọchị) na - ebute ike ọgwụgwụ nke ọrụ, mmechi akwara nke ductus arteriosus na nwa ebu n’afọ, ọbara ọgbụgba n’ime nne na nwa n’afọ, na nchịkwa ozigbo tupu amụọ nwa nwere ike ibute ọbara ọgbụgba intracranial, ọkachasị n’oge ụmụ aka. Nkwekọrịta nke salicylates na ọkara nke ọnwa ikpe-azụ bụ nke a machibidoro iwu.
Salicylates na metabolites ha na obere ihe na-abanye n'ime mmiri ara. Oge a na-enweta salicylates n'oge ị randomụ nwa anaghị esote mmeghachi omume ọjọọ n'ime nwa a, ọ chọghị ịkwụsị ịminationụ ara. Agbanyeghị, iji ọgwụ ogologo oge ma ọ bụ nhọpụta nke ị doseụ nnukwu ọgwụ, a ga-akwụsị inye nwa ara ozugbo.

Usoro usoro usoro onunu ogwu

Ekwesịrị iji ọnụ were ASA-cardio®, ọkacha mma tupu nri, na-akọghị, na-a waterụ nnukwu mmiri.
ASK-cardio® ezubere maka ogologo oge. Ọ bụ dibia bekee gara kpebie oge ọgwụgwọ ahụ. Na enweghị usoro ọgwụ ndị ọzọ, a na-atụ aro ka usoro ncheta usoro ndị a:
Akwụghị ụgwọ angina (nke nwere nnukwu myocardial infarction) ọgwụ mbụ nke 100-300 mg (a ga-ata ata mbadamba nkume mbụ maka ịnwe ngwa ngwa) onye ọrịa ga - ewere ya ozugbo enwere ike, mgbe enwere enyo enyo banyere mmepe nke infarction na-arịa nnukwu myocardial. N'ime ụbọchị iri atọ na-esote mgbe mmepe nke infarction myocardial, a ga-edozigharị ọnụọgụ nke 200-300 mg kwa ụbọchị.
Nnukwu mgbochi nke nnukwu myocardial infarction na ọnụnọ nke ihe ndị dị ize ndụ 100 mg kwa ụbọchị ma ọ bụ 300 mg kwa ụbọchị.
Mgbochi nke infarction myocardial. Anaghị akwụsi ike ma kwụsie ike angina pectoris. Mgbochi ọnya afọ mgbu na ọghọm ọrịa ụbụrụ. Mgbochi thromboembolism mgbe a wachara ya ahụ na mgbochi vaskụla ahụ na-emetụta 100-300 mg kwa ụbọchị.
Mgbochi nke thrombosis nke miri emi na thromboembolism nke akwara ọbara na alaka ya 100-200 mg kwa ụbọchị ma ọ bụ 300 mg kwa ụbọchị.

Mmekọrịta na ọgwụ ndị ọzọ

Site n'otu oge iji ASA na-akwalite ihe nke ọgwụ ndị na-esonụ, ọ bụrụ na ọ dị mkpa, ojiji nke ASA na ego ndị edepụtara kwesịrị ịtụle mkpa iji belata ọgwụ ọgwụ:
- methotrexate, n'ihi mbelata nke mkpocha akụrụ na mkpochapu ya na nkwukọrịta,
- iji otu oge eji anticoagulants, thrombolytic na antiplatelet (ticlopidine, clopidogrel), enwere ọghọm ọbara ọgbụgba n'ihi ọgbụgba nke isi ọgwụgwọ ọgwụgwọ nke ọgwụ ndị ejiri.
- iji otu oge eji ọgwụ ọjọọ anticoagulant, thrombolytic ma ọ bụ mmetụta antiplatelet, enwere mmụba na mmerụ ahụ na akpụkpọ mucous nke eriri afọ,
- nhọrọ serotonin reuptake inhibitors, nke nwere ike ibute ịba ụba ọbara ọgbụgba site na eriri afọ dị elu (njikọta yana ASA),
- digoxin, n'ihi mbelata nke gbasara akụrụ ya, nke nwere ike ibute ịdoụbiga mmanya ókè,
- ndị ọrụ hypoglycemic maka nchịkwa ọnụ (ihe dị n'ụkpụrụ sulfonylurea) na insulin n'ihi hypoglycemic Njirimara nke ASA n'onwe ya na oke ọnụọgụ na mbufụt nke ihe ndị na-esite na mmanụ protein plasma.
- iji otu ọgwụ a na - ejikọ ya na valproic acid, nsị ya na - abawanye n'ihi ngbanwe nke njikọ ya na protein protein plasma.
- NSAIDs na ihe ndị dị na salicylic acid na usoro onunu ogwu dị elu (ohere dị ukwuu nke utorogenic mmetụta na ọbara ọgbụgba site na eriri afọ n'ihi mmekorita synergistic), mgbe ejiri ya na ibuprofen, enwere antagonism na nkwanye ùgwù na mwepu platelet na-enweghị mgbanwe n'ihi ASA, nke na-eduga na mbelata mmetụta cardioprotective. Jụọ,
- Ethanol (ohere dị ukwuu nke imebi akpụkpọ ahụ mucous nke eriri afọ na oge ọbara na-agba ogologo oge n'ihi nkwalite mmekọrịta nke ASA na ethanol),
- Site n’otu oge eji acetylsalicylic acid (dị ka ihe nnọchianya antiplatelet) na igbochi ọwa kalsel “nwayọ”, ihe ize ndụ nke ọbara na-abawanye,
- Mgbe ejiri ọla edo mee ihe n'otu oge, acetylsalicylic acid nwere ike imebi mmebi imeju.

Site n'otu oge iji ASA na oke ọnụọgụ, ọ na-ebelata ike nke ọgwụ ndị edepụtara n'okpuru, ọ bụrụ na ọ dị mkpa, nchịkwa nke imekota ASA na ọgwụ ndị edepụtara kwesịrị ịtụle mkpa mmezi nke ọgwụ ndị edepụtara:
- ọnya ọ bụla (mgbe ejikọtara ya na ASA na usoro ọnụọgụ dị elu, a na-ebelata ọnụego mkpokọ nke glomerular (GFR) n'ihi mbelata njikọta nke prostaglandins na akụrụ),
- a na - ahụta ndị na - egbochi angiotensin n'ịtụgharị enzyme (ACE) (a na - ahụta mbelata ihe na-emetụta ya na GFR) n'ihi mgbochi nke prostaglandins nwere mmetụta vasodilating, n'otu aka ahụ, adịghị ike mmetụta hypotensive. A na-ahụta mbelata nke ụlọ ọgwụ na GFR kwa ụbọchị nke ASA kwa ụbọchị karịa 160 mg. Edebere ndị ọrịa maka ọgwụgwọ nke ọrịa obi na-adịghị ala ala. A na-egosikwa mmetụta a mgbe ejiri ya na njikọ ọnụ na ASA na nnukwu doses)
- ọgwụ na uricosuric edinam - benzbromaron, probenecid (ibelata uticosuric utịp ke asọmpi mgbachi nke akpo tubular urinary acid excretion),
- iji otu sistemu glucocorticosteroids (ewezuga hydrocortisone, nke eji mee ihe maka ọgwụgwọ ọrịa Addison), enwere mmụba na mwepụ nke salicylates na, n'ihi ya, adịghị ike n'ọrụ ha.
Ihe antacids nwere magnesium na / ma ọ bụ aluminom na-ebelata ma belata nnweta nke acetylsalicylic acid.

Mmetụta ikike ịkwọ ụgbọala, usoro

N'oge ọgwụgwọ, a ga-akpachara anya mgbe ị na-eme ihe egwu nwere ike ịchọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor (ịkwọ ụgbọ ala, iji usoro na-akpụ akpụ, ọrụ onye na-ebugharị na onye ọrụ, wdg), dị ka ọgbụgba ga-ekwe omume.

Weputara udi ya na ihe mebere ya

A na-enye ọgwụ ahụ n'ụdị mbadamba - ndị emepụtaghị ya maka usoro ọgwụgwọ ọzọ. Agba nke mbadamba ahụ na-acha ọcha, ọdịdị ahụ dị okirikiri, kpuchie ya na membrane nke na-agbaze n'ime eriri afọ mgbe nchịkwa gasịrị.

ASA cardio bu ogwu eji eme ka aru oria ghara idi ire aru, nke dokwara ihe ochichi.

Mbadamba ụrọ dị na mpekere iri. E mejupụtara blisters na ngwugwu kaadiboodu. Maka ịdị mma nke onye zụrụ ahịa, ngwugwu nwere ọnụọgụ blisters dị iche iche - 1, 2, 3, 5, 6, ma ọ bụ 10 iberibe.

Mbadamba ụrọ na-etinyekwa n’ime ite nke ihe polymer. Onye rụpụtara na-enye ite nwere ọnụ ọgụgụ dị iche iche mbadamba - 30, 50, 60 ma ọ bụ 100 iberibe.

Mmetụta ọgwụ na-emetụta ọgwụ bụ n'ihi ihe ndị na-arụ ọrụ, nke bụ ASA (acetylsalicylic acid). Mbadamba ụrọ ọ bụla nwere 100 mg. Iji meziwanye ọgwụgwọ ọgwụgwọ nke mbadamba nkume ndị ahụ, a na-etinye ihe ndị ọzọ - stearic acid, polyvinylpyrrolidone, wdg.

Omume ọgwụ

Ọgwụ ahụ na-anagide okpomọkụ, nwere ezigbo analgesic mmetụta, na-enwe ike ịnagide nchịkọta platelet. N'ihi ọnụnọ acetylsalicylic acid dị na ihe mejupụtara ahụ, ọgwụ ahụ na-enyere aka izere ọrịa strok na infarction myocardial maka ndị mmadụ na-arịa ọrịa angina pectoris na-ejighị n'aka.

Onye na-a aụ ọgwụ iji gbochie ya nwere ike ibute ọrịa gbasara ọrịa obi. Medicine medicineụ ọgwụ dịka prophylactic na-ebelata ohere ọgịga ọbara.

Mlọ ọgwụ

N'ime oge dị mkpirikpi, ASA na-etinye obi gị dum na eriri afọ, na-agbanwe ghọọ salicylic acid, nke bụ isi metabolite. Enzymes na-eme ihe na acid, ya mere a na-emegharị ya na imeju, na-akpụ metabolites ndị ọzọ, gụnyere glucuronide salicylate. A na-ahụ metabolabolites na mmamịrị na anụ ahụ dị iche iche.

A na-ahụta ihe kachasị ukwuu n'ime ihe na-arụ ọrụ n'ime ọbara n'ihe na-erughị ọkara otu awa mgbe ị .ụ ọgwụ ahụ.

Ọkara ndụ nke ọgwụ na-adabere na ọgwụ a .ụrụ. Ọ bụrụ na a na-ewere ọgwụ ahụ n'obere obere, mgbe ahụ, oge ahụ ga-ewe awa 2-3. Mgbe ị na-a largeụ nnukwu onunu ogwu, oge a na-abawanye ruo awa iri na isii na ise.