Ihe ngosi na ntuziaka maka ojiji gliclazide mb

Mellitus na-arịa insulin na-abụghị insulin bụ ụdị ọrịa ahụ (90-95% nke ọrịa shuga niile). Njikwa dị mma nke ọrịa na-adịghị ala ala chọrọ ọ bụghị naanị mgbanwe ndụ, kamakwa usoro ọgwụgwọ ọgwụ mgbe niile. Ihe di iche iche nke sulfonylurea (SM) bu kwa ihe edere na listi ogwu di nkpa maka onye oria shuga –n’otu n’ime usoro ọgwụgwọ kacha ewu ewu maka algorithm obula.

Nrụpụta dị elu yana ezigbo ịnabata ikike na ikike ịba ụba nwere ohere iji ihe ndị a SM mee ogologo oge dị ka ndị isi nke ndị na - ahụ maka hypoglycemic oral, na - echekwa ha na usoro ọgwụgwọ ọbụna mgbe ị na - agbanwe insulin.

Ezigbo ọgwụ antidiabetic taa kwesịrị ịdị mfe iji jikwaa, yana ntakịrị ihe ọghọm nke nsonaazụ ndị ọzọ (yana ọ bụghị naanị hypoglycemia), enweghị ọnụ, ịdabere na nke ọma na nchekwa. Emezuru ihe ndị a niile Gliclazide (na Latin Gliclazide) bụ ọgwụ mbụ nke klaasị CM.

Pharmacology Glycaside

Gliclazide, foto nke enwere ike ịhụ na nkebi a, bụ ọgwụ na-anọchite anya klas nke ndị si SM nke ọgbọ nke abụọ.

Ihe bụ isi (mana ọ bụghị naanị) mmetụta nke ọgwụ ahụ bụ hypoglycemic: ọ na-eme ka mmepụta insulin endogenous pụta site na mkpụrụ ndụ pancreatic b. Site n'ịkpali muscle glycogen synthase, gliclazide na-eme ka uru glucose uru ahụ dị. Ọgwụ na-eweghachi ọgwụ glycemic ngwa ngwa, tinyere ọrịa shuga metabolic latent.

Site na nnata nri na nri diges ruo oge nnabata nke insulin na mbadamba, ọtụtụ oge gafere karịa na-enweghị ha. Hyperglycemia, nke oriri nke carbohydrates na-akpasu iwe, na gliclazide adịghị emerụ ahụ.

Pharmacokinetics nke ọgwụ

Site na ngwara nri, a na-etinye ọgwụ ahụ ozugbo na zuru ezu. A na-enweta ọkwa kachasị elu na oke site na awa 2 ruo 6, yana maka mbadamba ụyọkọ na-enwe ogologo oge - site na awa isii ruo awa iri na abụọ. Ogologo oge nke ikpughe bụ ụbọchị nkezi. Na protein protein, a na-ejikọ ọgwụ ahụ na 85-99%. A na-eme ọgwụ ahụ n’ime imeju, mejupụta metabolites, otu n’ime ha na-emetụta microcirculation n’ezie.

A na-ewepụ ndụ ndụ ọkara na oke elekere 8-12. Na Gliclazide MV - awa 12-16. N'otu oge ahụ, a na-ewepụ 65% nke ọgwụ n'ụdị metabolites na mmamịrị, 12% site na eriri afọ.

Kedu mgbe eji ọgwụ ahụ?

Emere ọgwụ a maka nchịkwa glycemic nke ọrịa shuga 2, ma dị ka monotherapy yana maka ọgwụgwọ ọgwụ ọnụ na ọgwụ nje ndị ọzọ.

Ntuziaka Gliclazide na-atụ aro iji dịka akụkụ nke ogige maka ọgwụgwọ nke nsogbu microcirculation. Maka ebumnuche mgbochi, a na-enye ọgwụ iji gbochie mmepe nke nsogbu na ọrịa shuga - retinopathy, neuropathy, nephropathy, strok na nkụchi obi.

Contraindications maka Gliclazide

Ndepụta contraindications emetụtaghị naanị Glyclazide, kamakwa ọ bụ analogues ya niile (ya na akụrụngwa na-arụ ọrụ na-arụ ọrụ).

Otu n'ime ihe ndị amachibidoro iwu:

Diabetesdị shuga 1, ihe mgbochi iji ya

Nanị mmachi bụ afọ ụmụaka, ebe nchekwa na ịdị irè maka ìgwè ndị ọrịa a.

N'ụfọdụ ọrịa ọrịa (ịwa ụhọrọ, ọmụmụ akwara), a na-achọgharị insulin nwa oge (ọ na-abụkarị awa 48 tupu yana 48 ka usoro ahụ gachara).

Usoro ọgwụgwọ nke iji ọgwụ ọjọọ eme ihe bụ afọ ime, ọ bụrụ na a na-eme ya n'oge a na-enye nwa ara, a ga-enyefe nwatakịrị ahụ na nri aka nwa.

Nsonaazụ

N'oge na-adịbeghị anya, akwụkwọ apụtawo na Europe na USA banyere njikọ dị n'etiti njikọ nke nchịkwa nke ihe omume SM na nkwadebe insulin na ohere nke ọrịa akwara na ọrịa ọrịa cancer. Ozi ekwenyeghi, ebe ọ bụ na gliclazide bụ ọgwụ mbụ, ọ nyochaala nchekwa nchekwa zuru oke.

Ndepụta zuru oke nke nsonaazụ a na-atụghị anya ya dị na tebụl.

N'iburu n'uche ihe ize ndụ nke ọnọdụ hypoglycemic, emela Gliclazide maka ndị ọrịa shuga na-arịa ọrịa na-ezighi ezi na enweghị nkwado mmekọrịta ọha na eze, karịsịa na ọrịa obi na ọrịa gbasara akụrụ.

Njikọ Ọgwụ

Gliclazide nwere ike ịkwalite ACE inhibitors, steroid anabolic, β-blockers, fluoxidine, cimetidine, salicylates, miconazole, MAO inhibitors, fluconazole, theophylline, pentoxifylline, tetracyclines.

A na - ebelata mmetụta nke glycoside site na iji ya mee ihe yiri nke barbiturates, glucocorticoids, sympathomimetics, saluretics, ọgwụ mgbochi mkpịsị, rifampicin, estrogens.

Otu esi etinye

A na-ewere ọnụ glycloside na nri. Erere mbadamba ihe nile, n withoutwepughi ya, were miri kwue ya. Dọkịta ga-ahọpụta usoro onunu ogwu n’otu n’otu, na-ebido n’usoro oria ya na mmeghachi omume nke ndị ọrịa shuga na ọgwụ. Thekpụrụ ịmalite adịghị abụkarị 80 mg, ma ọ bụrụ na ọ naghị arụ ọrụ nke ọma, a na-eji nwayọọ nwayọọ na-abawanye ọgwụ ahụ.

Normkpụrụ dị kwa ụbọchị sitere na 30 mg ruo 120 mg, na-eburu n'uche usoro nke ọrịa shuga na mgbochi afọ. N'ọnọdụ ụfọdụ, enwere ike inye ọgwụ ọgwụ ruru 320 mg.

Ọ bụrụ na anabataghị nnabata oge a, ịnweghị ike okpukpu abụọ nke ọnụego a. Ekwesịrị ị Theụ ọgwụ ahụ na ohere mbụ.
Ojiji nke ikpokọtara enwere ike ọ bụghị naanị na metformin, nke naanị a na-eji ọtụtụ ebe karịa ndị nnọchi anya SM, kamakwa na usoro atọ guzobere.

Nri ụtụtụ, nke na-a theụ ọgwụ ahụ, kwesịrị ịdị nke ọma, yana ikike pere mpe nke carbohydrates. Agụụ na-agụ ụbọchị, karia oke ibu, nwere ike ịkpalite hypoglycemia. Ọnọdụ yiri ya ga-ekwe omume mgbe ị alcoholụsịrị mmanya.

Ndị ọrịa mamịrị n'oge okenye, na-akpachapụ anya gbasara Glyclazide, ebe ọ bụ na ha nwere ike ịmalite glycemia. Ọgwụ dị mkpụmkpụ dịka Glyclazide oge ọ bụla dabara adaba maka ụdị ndị ọrịa a.

Mbadamba ịtọhapụ weghaara ọrụ ụbọchị niile, na nhazi nke ọgwụ dị otu. Usoro onyonyo nke Gliclazide MV bụ ọkara nke ụdị ọkọlọtọ. Ọgwụ dị irè ruo afọ 3-5, mgbe ahụ enwere ike nke iguzogide na-abawanye - akụkụ ma ọ bụ na-enweghị oke nke arụmọrụ ya. N'ọnọdụ ndị dị otú ahụ, endocrinologist na-agbanwe usoro ọgwụgwọ.

Originalụ ọgwụ mbụ, dị ka mkpụrụ ndụ ihe nketa ya, dị irè naanị n'ịgbanwe ụdị obibi ndụ - nri na-edozi ahụ nke ọma, ezigbo anụ ahụ na mgbatị ahụ anya, na-elele ọnọdụ mmetụta uche, na-ahụ maka ụra na izu ike.

Kwesịrị dị mkpa bụ ilekọta glycemia n'ehihie na idekọ nsonaazụ ya na mkpụrụedemede ọrịa mamịrị. Mgbe enwere oke nrụgide, arụ ọrụ anụ ahụ, erighị nri na-edozi ahụ, usoro iji usoro onunu ogwu nwere ike ịdị mkpa. Nyochaa onodu gị na dọkịta gị mgbe niile ga - enyere aka ịzere nsonaazụ ya.

Ihe mgbochi

Maka igbochi mwakpo hypoglycemic, ọ dị mkpa iri nri ụtụtụ mgbe mkpụrụ ọgwụ ahụ kwụsịrị, gbochie agụụ n'oge ehihie, ma wezuga mmanya na nri.Ojiji ojiji nke b-blockers nwere ike kpuchie mgbaàmà hypoglycemic. Ọ dị mkpa ka ndị na-arịa ọrịa shuga soro nri ndị nwere obere carb.

Nyere onye ahụ metụtara aka ị anụbiga mmanya ókè

Ọ bụrụ na iwu ga - enyefere oke iwu, ihe ịrịba ama nke ịdoụbiga ihe ókè nwere ike ịpụta:

1. Ike gwụrụ m
2. Ọbara mgbali elu
3. Isi ọwụwa
4. Obi erughị ala, iwe,
5. Na-egbochi mmeghachi omume,
6. Ahụhụ anya nwa oge,
7. Ọrịa Okwu,
8. Spasms
9. Ike gwụrụ.

Ọ bụrụ na ọrịa akpịrị bụ nke siri ezigbo ike na onye ọ na-enweghị ike ịchịkwa ọnọdụ ya, ọ kwesịrị ịga ụlọ ọgwụ ngwa ngwa. Iji kwụsị mwakpo ahụ n'oge awa mbụ, ọ dị mkpa ịbanye 50 mg nke glucose (30% r) na akwara na ntapu - dextrose (10% r) na akwara. Ọ dị mkpa n'oge mmalite iji nyochaa glycemia mgbe niile. Nchoputa banyere nnabata nke gliclazide adighi ike.

Usoro onunu ogwu na ihe eji eme ya

N'ihe banyere mgbasawanye, nkwadebe SM bụ nke abụọ naanị maka Metformin. Otu n'ime uru ọgwọ ọrịa dị bụ nnweta ya: maka Gliclazide, ọnụahịa dị n'igbe ọgwụ anaghị agafe 160 rubles. maka 30 pcs. Na netwọko ụlọ ahịa ọgwụ, a na-enye ọgwụ ọgwụ n'okpuru aha ahia dị iche iche: Glyclazide-Akos, Glyclazide Canon, Glidiab-MV. A na-emepụta ọgwụ ahụ n'ụdị dị iche iche, enwere nhọrọ na nweputara ntọhapụ nke akụkụ isi ahụ.

Mbadamba ụrọ nwere ude mmiri na-egbu egbu na obere marbling. N'ime sel nke alumini nwere ike ịbụ 10, 20 ma ọ bụ 30 PC. ọgwụ. A na-etinye blisters na igbe nke 10, 20, 30, 60 na ọbụna mbadamba 100.

Mbadamba ụrọ nke ọ bụla nwere gliclazide ihe dị n'ime ya, nke a na-agbakwunye ya na cellulose, hypromellose, colloidal silicon dioxide, magnesium stearate.

A na-ere ihe dị iche na mmetụta ogologo oge nke Glycaside MV na ngwugwu ndị yiri ya nke mbadamba 15 ma ọ bụ 30 na nnukwu ma ọ bụ igbe.

Ihe ọghọm ọghọm nke klaasị ọgwụ a bụ nzi omume nke iguzogide ọgwụ: dịka ọnụ ọgụgụ si kwuo, 5% ndị ọria mamịrị bụ ndị nara ọgwụ ụfọdụ nke SM ogologo oge ịgbanye insulin n'oge.

Generic Glyclazide

Gliclazide - ọgwụ mbụ, ọgwụ niile ọzọ nwere otu arụ ọrụ ma ọ bụ mmetụta ọgwụ, analogues. Glidiab nwere ọnụahịa kachasị mma na ọnụahịa dị mma n'etiti Gliclazide analogues na-efu 111-137 rubles. Ọgwụ Diabeton na Diabeton MV na-enye ndị dọkịta otuto dị elu. Ọnụahịa ọgwụ sitere na 250 ruo 320 rubles.

N'ime ọgwụ ndị ọzọ dabara na koodu ATX 4, ndị kachasị ewu ewu bụ:

• Glurenorm,
• Glimepiride
• Amix
• Glibenclamide,
• Amaril
• Maninil.

Ọ bụrụ na mgbe ịdechara Glyclazide, ihe ọhụrụ ọhụụ, nke na-enweghị nghọta, kọwaara dọkịta gị ahụ erughị ala. Ikekwe, mgbe nyochachara nke ọzọ, ọ ga-ebelata ọgwụ ma ọ bụ họrọ ahịrịokwu kwesịrị ekwesị. Nyocha site na iji mkpụrụ ndụ ihe egwu na-emetụta ahụ ike gị.

Gliclazide - nyocha nke ndị ọrịa mamịrị na ndị dọkịta

Ọgwụ hypoglycemic ọgbara ọhụrụ ụdị shuga kwesịrị ka emegasịrị, “ahaziri” mkpa nke otu onye ọrịa, ga-eburu n'uche afọ ya na njiri mara ụlọ ọgwụ iji belata nkwarụ, jiri ikike ịgbanwe ọrịa ogologo oge wee gbasaa ndụ ọrịa mamịrị.

N’ezie, Glyclazide adịghị mma maka mmadụ nile, yana ndị ọzọ na - ewetara shuga, agbanyeghị, enwere ike ịgbagha ya na ọgwụ yana analogs ya kwekọrọ na ụkpụrụ ọhụụ e kwupụtara, na-adị mkpa ma gaa n’ihu na-enyere ndị ọrịa mamịrị aka ịgwọ ọrịa nke ọma.

Banyere usoro ọgwụgwọ ọgwụgwọ ọrịa shuga ụdị goth 2 na vidiyo

Mlọ ọgwụ

Ọrịa hypoglycemic, nke bụ usoro nke usoro oyuche sulfonylurea II. Na-akwalite mmepụta nke insulin site na mkpụrụ ndụ-and-ma weghachi profaịlụ nke ahụ.Theakingụ ọgwụ ahụ na -ebelata oge site na oge iri nri ruo na mmalite insulin insulin, ebe ọ na-eweghachi usoro mbu (nke mbụ) ma buliekwa agba nke abụọ. Na -ebelata agbam ume kachasị elu mgbe ị risịrị nri. Ọ na - eme ka anụ ahụ mara insulin.
Na mgbakwunye, ọ na-ebelata ihe egwu. thrombosissite na-ebelata mkpọchi na nrapado ọgụgụ plateletna - eweghachi ọrịa anụ ahụ parietal fibrinolysisna - eme ka microcirculation dịkwuo mma. Mmetụta a dị mkpa n'ihi na ọ na-ebelata ohere nke nnukwu nsogbu - yana microangiopathies. Site na nephropathy mamịrị, enwere ịbelata n'oge ọgwụgwọ ọgwụ a. Ọ na - egbochi mmepe nke atherosclerosis, ebe ọ nwere ihe anti-atherogenic.

Njirimara nke usoro onunu ogwu Gliclazide MV nye ịta ahụ ọgwụgwọ na njikwa ọkwa glucose dị mma n'ime awa iri abụọ na anọ.

Ihe mgbochi ngwa

Nanị mmachi bụ afọ ụmụaka, ebe nchekwa na ịdị irè maka ìgwè ndị ọrịa a.

N'ụfọdụ ọrịa ọrịa (ịwa ụhọrọ, ọmụmụ akwara), a na-achọgharị insulin nwa oge (ọ na-abụkarị awa 48 tupu yana 48 ka usoro ahụ gachara).

Usoro ọgwụgwọ nke iji ọgwụ ọjọọ eme ihe bụ afọ ime, ọ bụrụ na a na-eme ya n'oge a na-enye nwa ara, a ga-enyefe nwatakịrị ahụ na nri aka nwa.

Glyclazide, ntuziaka maka ojiji (Usoro na usoro onunu ogwu)

Mbadamba nke Glyclazide N'usoro ọgwụ mbido 80 kwa ụbọchị, ugboro 2 n’ụbọchị 30 nkeji tupu nri. N’ọdị n’ihu, a na-agbazi ọgwụ a na-agbaso, kwa ụbọchị ị na-eri kwa ụbọchị bụ 160 mg, ma kacha bụ 320 mg. Mbadamba ụrọ Glyclazide MB nwere ike ịhụ mbadamba mbugharị oge niile. Ọ bụ dọkịta ga-ekpebi ihe ga-ekwe omume ma dochie ya na ọgwụ a.

Glyclazide MB 30 mg iri oge 1 n’oge nri ụtụtụ. A na-amalite ịgbanwe ọgwụ mgbe izu 2 gachara. Ọ nwere ike ịbụ 90 -120 mg.

Ọ bụrụ na ọgwụ gị riri gị ọgwụ, ị gaghị anara ya okpukpu abụọ. Mgbe ị ga-eji nke a dochie ọgwụ belata shuga ọzọ, oge mgbanwe agaghị achọ ya - ha ga - ebido were ya echi. Ikekwe ngwakọta na biguanides,, alfa glucosidase inhibitors. N'ime ogo dị nwayọ na n'ọdịdị, a na-ede ya otu usoro onunu ogwu. N'ime ndị ọrịa nwere ọrịa hypoglycemia, a na-eji ntakịrị ọgwụ.

Dodoụbiga ya ókè

A na - egosipụta oke nrịba ama site na mgbaàmà hypoglycemia: isi ọwụwa, ike ọgwụgwụ, adịghị ike siri ike, ịsụgharị, palpitations, ọbara mgbali elu, arrhythmiairo ụra mkpasu iweiwe, oke iwe, mmeghachi omume na-egbu oge, ọhụụ na-enweghị isi na okwu, ịma jijijianya ntughari ogwe, bradycardiaọnwụ nke mmụọ.

Na agafeghị oke hypoglycemiana-enweghị mmụọ ịta ahụhụ, belata dose nke ọgwụ ma ọ bụ nwekwuo ego nke carbohydrates na-enye nri.

Na ọnọdụ hypoglycemic siri ike, ịbanye n'ụlọ ọgwụ na enyemaka dị mkpa: iv 50 ml nke 20 glucose 20-30% gluu, mgbe ahụ 10% dextrose ma ọ bụ glucose na-asọpụta. N'ime ụbọchị abụọ, a na-enyocha ọkwa glucose. Dialysis adighi ike.

Mmekorita

Ojiji nke ndị na - egbochi beta na - ahọrọ ihe a na - ebute nsogbu ahụ hypoglycemia.

Mgbe itinye akwụkwọ Acarboseakara mmado hypoglycemic akara.

Mgbe ị na-eji GCS (gụnyere ụdị ngwa ọzọ). mgbochi ego, diuretics, estrogenna progestins., na-ebelata mmetụta belata shuga nke ọgwụ.

Omume ọgwụ

Nchịkọta hypoglycemic nke na-ahụ maka ọnya, ihe dị na usoro nke sulfonylurea nke ọgbọ nke abụọ. A na-akwalite mmiri ọgwụ insulin site na sel-nke pancreas. Ọ na-eme ka ahụrịị anụ ahụ dị elu na insulin. O doro anya, ọ na-akpali ọrụ nke enzymes intracellular (karịchaa, akwara glycogen synthetase). Na-ebelata oge dị n'etiti oge iri nri rue mmalite insulin insulin.Weghachi mbido insulin nke mbụ, na-ebelata oke postprandial nke hyperglycemia.

Glyclazide na-ebelata nrapado platelet na nchịkọta, na-ebelata mmepe nke thrombus parietal, na -emekwa ọrụ fibrinolytic vaskụla. Normalizes vaskụla permeability. Ọ nwere ihe anti-atherogenic: ọ na-ebelata mkpokọta cholesterol (Ch) na LDL-C na ọbara, na-eme ka ịtawanye eleba anya nke HDL-C, ma belata ọnụ ọgụgụ nke radical n'efu. Na-egbochi mmepe nke microthrombosis na atherosclerosis. Ọ na - eme ka microcirculation dịkwuo mma. Na-ebelata akwara vaskụla na adrenaline.

Site na nephropathy na-arịa ọrịa mamịrị na iji gliclazide ruo ogologo oge, a na-achọpụta mbelata pụtara na proteinuria.

Ntụziaka pụrụ iche

A na-eji Gliclazide gwọọ ọrịa mellitus na-abụghị insulin na-etinye ya na obere kalori, nri nwere obere carb.

N'oge ọgwụgwọ, ị kwesịrị ị na-enyocha ọkwa nke glucose n'ọbara na afọ na-enweghị nri na mgbe ị risịrị nri, na-agbanwe kwa ụbọchị na ọkwa glucose.

N'ihe banyere usoro ịwa ahụ ma ọ bụ mejupụta ọrịa shuga mellitus, ọ dị mkpa iburu n'uche ohere nke iji insulin insulin eme ihe.

Site na mmepe nke hypoglycemia, ọ bụrụ na onye ọrịa maara, a na-edenye glucose (ma ọ bụ ihe ngwọta shuga) n'ime. Ọ bụrụ na mmụọ amaghị, a na-edozi glucose intravenous ma ọ bụ glucagon sc, intramuscularly ma ọ bụ intraven. Mgbe ọ nwetasịrị, ọ dị mkpa inye onye ọrịa ahụ nri nwere carbohydrates iji zere ịmaliteghachi hypoglycemia.

N'iji oge nke gliclazide na verapamil, a chọrọ nlezianya nke ọkwa glucose ọbara, yana acarbose, jiri nlezianya na-agbazi ma na-agbazi usoro nchịkwa nke usoro hypoglycemic.

Ekwesighi iji gliclazide na cimetidine n'otu oge.

Mkparịta ụka ọgwụ ọjọọ

Mmetụta hypoglycemic nke gliclazide bụ nke a na-eji ya eme ihe na iji ya eme ihe na pyrazolone, salicylates, phenylbutazone, antibacterial sulfonamides, theophylline, caffeine, MAO inhibitors.

Ojiji nke beta-egbochi na-eme ka enwee ike ịbawanye hypoglycemia, ọ nwekwara ike ikpuchi tachycardia na ịma jijiji aka, njirimara nke hypoglycemia, ebe ịchafụ nwere ike ịba ụba.

N'iji oge nke gliclazide na acarbose, a na-ahụ mmetụta hypoglycemic na-eme ihe.

Cimetidine na-eme ka ịbawanye ụba nke gliclazide na plasma, nke nwere ike ibute nnukwu hypoglycemia (ịda mbà CNS, nsụhọ nke uche).

Site na iji GCS n'otu oge (gụnyere usoro onunu ogwu maka iji mpụga), diuretics, barbiturates, estrogens, progesins, ọgwụ estrogen-progestogen jikọtara ọnụ, diphenin, rifampicin, mmetụta hypoglycemic nke glyclazide belatara.

Nkọwa nke ọgwụ "Gliclazide"

Ọgwụ "Glycliazide" na-ezo aka na usoro sulfonylurea (ọgbọ nke abụọ) ma nwee mmetụta hypoglycemic. Enwere ike iji ọgwụ a na-agwọ ọrịa shuga na-adịghị insulin. Ebumnuche bụ isi nke ọgwụgwọ Glycliazide bụ belata glucose ọbara. Ọzọkwa, a na-ejikarị ọgwụ carbohydrate na ụlọ ahịa ọgwụ ị nwere ike ịzụta ọgwụ n'okpuru aha "Glyclazide-Akos", "Glidiab-MV".

Ihe dị n’otu aha ahụ na-emetụta ọnọdụ nke akwara ọbara, na-eweghachi ike ha na igbochi mmepe nke atherosclerosis. Ogologo oge ị ofụ ọgwụ ahụ na-eme ka mbelata proteinuria dị ukwuu (ọnụnọ protein na mmamịrị). Na-emegide usoro ọgwụgwọ na onye nnọchi anya, a ga-ebelata ihe ize ndụ nke ịmalite iku ume endetal thrombosis.

Edebere oke ihe dị n'ime ọbara ahụ ka ọ dị awa 6-12 ka ewerechara mbadamba "Gliclazide". Ihe analogs nke ọgwụ ahụ egosikwala onwe ha nke ọma, mana dọkịta kwesịrị ịhọrọ ha n'otu n'otu.Dịka akụkụ nke ọgwụ mbụ, ihe eji arụ ọrụ bụ gliclazide gbanwetụrụ.

Ihe ngosi maka oge atọrọ

Dabere na nkọwapụta ahụ, "Gliclazide" ka enyere ndị mmadụ ọrịa nwere ụdị shuga 2 (shuga). Hogwọ ọrịa ụbụrụ dị iche n'ụdị nke mbụ na nke abụọ, na - egbochi insulin nke ahụ na - emepụta onwe ya na - akwụsị kpamkpam. A na-ahụta isi ihe mere eji ebute ọrịa dị ka ịka nká. Agbanyeghị, ọnụnọ nke kilogram na oke ike nke carbohydrates na nri nwekwara ike ịkpalite mmepe nke ọrịa shuga.

A na-atụ aro mbadamba Glyclazide maka iji ya dịka akụkụ nke usoro ọgwụgwọ siri ike maka nsogbu microcirculatory. Maka ebumnuche mgbochi, enyere ọgwụ ọgwụ iji gbochie mmepe nke nsonaazụ ọjọọ nke ọrịa shuga: ọrịa strok, nkụchi obi, nephropathy, retinopathy.

Etu esi ewere Glyclazide?

A na-ahọpụta usoro onunu ogwu site n’aka ndi okacha amara n’otu n’otu. Thebọchị kwa ụbọchị nwere ike ịdị iche n'etiti 30-120 mg nke ihe na-arụ ọrụ, dabere na ọnọdụ onye ọrịa ahụ yana afọ ya. Were mbadamba nkume otu ugboro n'ụbọchị tupu nri (ọkacha mma na afọ efu).

Ọ bụrụ n’ikpebie ị takingụ ọgwụ, a naghị atụ aro ka ị nwekwuo usoro onunu ogwu. N'ọnọdụ ụfọdụ, oke ọgwụ nwere ike iru mg mg.

Akụkụ nke iji ọgwụ ahụ "Gliclazide"

Analogues nke ihe nnọchianya hypoglycemic, dị ka ọgwụ mbụ n'onwe ya, ka ejiri ya na nri nwere obere kalori, nke na-egosi ojiji nke obere carbohydrates. Ọ dị mkpa ijikwa ọkwa glucose dị n'ọbara ọbara tupu nri amalite na mgbe ị gachara. Ghazigha etu ogwu a si mesoo mgbe nsogbu mmetu obi ma obu mgbali aru.

Enwere ike ịgwọ ọgwụ ahụ site na ahụ ọkụ site na oke ọkụ, ihe ndị metụtara ịwa ahụ. Iji otu oge Glyclazide na ethanol nwere ọgwụ, ọgwụ mgbochi na - abụghị ọgwụ steroid, enwere ihe ize ndụ nke hypoglycemia. Ethanol nwere ike ibute afọ mgbu, ọgbụgbọ, na ọgbụgbọ.

A na-ahụ ọgwụ Sulfonylurea ọgwụ dị mkpa n'ịgwọ ọrịa shuga. Ihe ọghọm ha dị mkpa gụnyere mmepe nke nguzogide. A na-ahụ ọnọdụ yiri nke ahụ na 5% nke ndị ọrịa, bụ ndị a na-agafere na ọgwụgwọ insulin.

Enwere ike dochie ọgwụ a "Gliclazide", ọnụahịa nke sitere na 130-160 rubles kwa mkpọ (mbadamba 30), iji ọgwụ dochie ya. Dabere na gliclazide, a na-emepụta ọgwụ ndị na-ahapụ ntọhapụ. A na-ewere ọgwụ ndị na-esonụ nke ọgwụ mbụ dị ka ndị dị irè:

Ọgwụ ndị Glyclazide nwere mmetụta dị mma na microcirculation, pịnara hematological, usoro hemostasis. Nke a dị ezigbo mkpa maka ndị ọrịa nwere ọrịa shuga 2. Dọkịta ahụ kwesịrị ịhọrọ ọgwụ iji kpalie mmepụta insulin. Okwesiri iburu n’uche na ụdị ọgwụgwọ ọgwụgwọ ahụ gụnyere mmụba n’arụ ahụ.

"Diabefarm": ntuziaka maka ojiji

Ihe nnọchianya nke hypoglycemic dị na ụdị mbadamba. Otu mbadamba ihe nwere 80 mg nke isi ihe na - arụ ọrụ nke gliclazide. Dị ka ihe ntinye aka, a na-eji shuga mmiri ara ehi, magnesium stearate, povidone. Onye rụpụtara - ụlọ ọrụ na-emepụta ọgwụ Russia - na-emepụta ọgwụ Diabefarm MV nwere ntọhapụ gbanwee. N'ime mbadamba nkume ndị a, a na-ebelata usoro onodu ihe arụ ọrụ n'ime 30 mg. Ntọhapụ pụtara n'ime awa 24.

Onu ogwu ghoro otu. Dọkịta na-atụle ọkwa nke glucose n'ọbara ọbara, afọ onye ọrịa na akara nke ọrịa ahụ. Ọgwụ nke mbụ kwa ụbọchị ekwesịghị gafere 80 mg. N'ọdịnihu, ọ na-abawanye ruo 160-320 mg nke glycazide.

Ntụziaka ntinye "Diabefarm" na-atụ aro ka etinyere ya maka ndị ọrịa toro eto eto maka usoro ọgwụgwọ nri na mmega ahụ anaghị arụ ọrụ.Ekwesịrị ị were mbadamba ndị gbanwere (MV) 1 oge kwa ụbọchị. Dọkịta gị nwere ike ịbawanye usoro ị ga-a afterụ mgbe ị nwesịrị nnwale ọbara.

Ọgwụ "Glidiab"

Onye ọzọ hypoglycemic onye nwere ọgwụ ọgwụgwọ akpọsa bụ Glidiab. Ntuziaka maka iji gosipụta na n'otu mbadamba ihe nwere 80 mg nke ihe na-arụ ọrụ nke gliclazide. Otu ngwugwu nwere 60 mbadamba. Ọnụ ego ọgwụ dị 110-140 rubles. Edere Glidiab MV, ọnụahịa nke ọnụego ya bụ 140-170 rubles, ka enyere ndị ọrịa ọtụtụ oge.

Ihe omume nke ogwu a sitere na nkwalite nke sel na pancreas na-emepụta insulin. Glidiab nwere ike iweghachi ọnụ ọgụgụ izizi nke insulin, nke na-enye ya ọdịiche site na ụfọdụ ọgwụ ndị ọzọ site na otu nke usoro sulfonylurea.

4 awa mgbe ị theụsịrị ọgwụ ahụ, a na-ahụta ohere kachasị nke gliclazide n'ime ọbara ọbara. Ọgwụ na-etinye obi gị dum na eriri afọ eriri afọ kpamkpam.

Diabeton MV

Ọgwụ “Diabeton” na gbanwetụrụ ikike nke ihe na-arụ ọrụ bụ nke otu nke usoro sulfonylurea nke ọgbọ nke abụọ. Otu ihe pụrụ iche bụ ọnụnọ nke mgbanaka N-heterocyclic, nke nwere njikọ endocyclic. Ndị ọkachamara chọpụtara na mgbe ị na-a theụ ọgwụ ahụ ruo afọ abụọ, iguzogide anaghị eto eto.

A na-ezube ngwaọrụ ahụ naanị maka ịgwọ ndị ọrịa okenye, dị ka ọgwụ mbụ "Gliclazide." Ọnụahịa ọgwụ French bụ 320-370 rubles kwa ngwugwu (iberibe 30).

A na-ahụkarị mgbanye gliclazide n'ime ọbara 6 awa elekere isii tupu ị .ụ ọgwụ ahụ. Nke a na - enyere gị aka belata ọnụ ọgụgụ ọgwụ kwa ụbọchị. Ọtụtụ mgbe, ndị dọkịta na-atụ aro ị tabletsụ mbadamba 1-2 kwa ụbọchị. Ọkachamara na ndị ọrịa na-ahapụ nyocha dị mma gbasara ọgwụgwọ ọgwụ a.

Ndị ọrịa kwesịrị ịmara na lactose bụ akụkụ nke ọgwụ. Ya mere, ekwesighi iji ya were nnabata ihe a ma obu galactosemia.

Dabere na nyocha, a na-ewere Diabeton MV dị ka otu n'ime ndị ọrụ kachasị dị irè sitere na ụdị nke usoro sulfonylurea. Otu uru dị ukwuu bụ ọgaghị adịkarị ma ọ bụrụ na ị na-a theụ ọgwụ. Naanị ọkachamara nwere ike ikpebi usoro onunu ogwu yana usoro ọgwụgwọ. Ekwesịrị ibu ụzọ nyochaa onye ọrịa ahụ. Ọ bụ ihe na-achọghị oke mma iji ọgwụ nke aka gị belata glucose dị ala.

A na-ewepụta analogs Gliclazide mv, dịka usoro okwu ahụike siri kwuo, nke a kpọrọ 'okwu mmekọrịta' - ọgwụ na-agbanwe agbanwe nke nwere otu ma ọ bụ karịa otu ihe ahụ na-arụ ọrụ ka ha na-emetụta ahụ. Mgbe ị na-ahọrọ okwu ntụgharị, tụlee ọ bụghị naanị ọnụ ahịa ha, kamakwa mba mmepụta na aha onye mere ya.

Ndepụta nke analogues

Attentionaa ntị! Ndepụta ahụ nwere ihe nnọchiaha nke Gliclazide MV, nke nwere ụdị ihe mejupụtara, yabụ ị nwere ike ịhọrọ onye nnọchi onwe gị, na-eburu n'uche ụdị na ụdị ọgwụ dọkịta gị nyere. Nye ndị na-emepụta ihe si USA, Japan, Western Europe, yana ụlọ ọrụ ndị ama ama sitere na Eastern Europe: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Ndị ọbịa anọ kwuru oge nnabata

Kedu oge kacha mma iji were Glyclazide MV: na afọ na-enweghị isi, tupu, mgbe, ma ọ bụ jiri nri?
Ndị na-eme ihe ntanetị na-akọkarị ka ị takingụ ọgwụ a na afọ efu. Agbanyeghị, dọkịta nwere ike ịkwado oge ọzọ. Akuko ahụ gosipụtara mgbe ndị ọrịa ndị ọzọ gbara ajụjụ ọnụ na-a theụ ọgwụ.

Ntụziaka gọọmentị maka ojiji

Aha International nonproprietary: Gliclazide * (Gliclazide *)

Usoro onunu ogwu: ọgwụ
Ngwakọta: Otu mbadamba 1 nwere:
Ihe na-arụ ọrụ: Gliclazide MV -20 mg, 40 mg ma ọ bụ 80 mg.
Ndị ọkachamara: microcrystalline cellulose, stachi, povidone, sodium methyl paraben, colloidal silicon dioxide, aerosil, magnesium stearate, sodium starch glycolate, talc, mmiri dị ọcha.
Nkọwa:
Mbadamba mbadamba ụcha nke na-acha ọcha, na -eme ka egbugbere ọnụ ya na eriri mmebi dị n'otu akụkụ.
Otu na-ere ọgwụ:
hypoglycemic agent ATS koodu: A10BB09.

Glyclazide-akpachara anya

N'oge usoro ị doseụ ọgwụ, ọkachasị mgbe ejikọtara ya na ọgwụ insulin, ọ dị mkpa iji chọpụta profaịlụ shuga na mgbanwe nke glycemia, n'ọdịniihu a na-ahụ maka ọkwa glucose ọbara n'ọdịniihu. Maka igbochi hypoglycemia, ọ dị mkpa n'ụzọ doro anya na oriri, zere agụụ ma kwụsị ị useụ mmanya. Ojiji nke beta-igbochi egbochi nwere ike ikpuchi ihe ngosi nke hypoglycemia. A na-atụ aro iji obere carb, nke nwere obere carb. Jiri ịkpachara anya na-arụ ọrụ maka ndị ọkwọ ụgbọ ala na ndị ọrụ ha jikọtara na itinye uche ha na nlebara anya.

Aha ahia

Ọgwụ Gliclazide MV na-ezere hyperinsulinemia ogologo oge, nke bụ isi ihe dị na pathogenesis nke ụdị shuga 2.
Otu na-ere ọgwụ:
Ndị nnọchianya na-arịa ọrịa hypoglycemic, na-ewepụ insulins. Sulfonamides, usoro nke sulfonylurea. Gliclazide.

Ofzọ nke ngwa

Mmetụta:
Ọgwụgwọ Glyclazide MV nwere ike ibute hypoglycemia n'ọnọdụ nke nri oriri na-adịghị adị oge ụfọdụ yana ọkachasị n'ihe banyere iri nri.
Ihe mgbaàmà puru iche nke hypoglycemia: isi ọwụwa, agụụ siri ike, ọgbụgbọ, ọgbụgbọ, ike ọgwụgwụ, nsogbu ụra, iwe, iwe, adịghị ike nke itinye uche gị, belata ikike ịtụle ọnọdụ ahụ na mmeghachi omume oge na-egbu oge, ịda mba, enweghị nghọta, nsogbu ọhụhụ na nsogbu okwu, aphasia, ịma jijiji. , paresis, mbelata nke uche, nkụda mmụọ, mmetụta nke enweghị enyemaka, ọnwụ nke njide onwe onye, ​​ọnọdụ enweghị atụ, nsogbu iku ume, enweghị ume, bradycardia, ura na ọnwụ nke mmụọ, nke nwere ike ibute ya sachaa ma ọ bụ egbu egbu. Na mgbakwunye, akara nke adrenergic counterregulation dị ka ọsụsọ, akpụkpọ clammy, nchegbu, tachycardia, ọbara mgbali elu, ọnya obi, angina pectoris na obi arrhythmia nwere ike ime.
Ọtụtụ mgbe, mgbaàmà ndị a na-apụ n'anya mgbe ha nwesịrị carbohydrates (sugar). N'otu oge, ndị na-atọ ihe ụtọ adịghị enwe mmetụta a.
N'ime mwakpo siri ike na ogologo oge nke hypoglycemia, ọbụlagodi na ọ nwere ike iwepụ shuga nwa oge, ọ dị mkpa ịnye nlekọta ahụike ma ọ bụ, ọ bụrụ na ọ dị mkpa, ọbụlagodi onye ọrịa.
Mmetụta ndị ọzọ achọghị:
nsogbu nke eriri afọ (ọgbụgbọ, afọ ọsịsa, mmetụta nke oke na afọ, afọ ntachi, afọ mgbu, ọgbụgbọ, ọgbụgbọ). Mgbaàmà ndị a adịkarịghị na nhọpụta nke Gliclazide MV n'oge nri ụtụtụ.
Ọ na-esiri ike ịkọpụta nsonaazụ ndị a:
Mmeghachi omume nfụkasị ahụ: itching, urticaria, flopi maculopapular,
site na usoro hematopoietic na lymphatic: mgbanwe nke hematological. Nke a nwere ike bụrụ anaemia, leukopenia, thrombocytopenia, granulocytopenia. Ọtụtụ mgbe, mgbaàmà ndị a na-apụ n'anya mgbe ị kwụsịrị ị theụ ọgwụ,
ọgba aghara nke imeju na ọnya: ọrụ dị elu nke enzymes “imeju” (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), ịba ọcha n'anya (ikpe ndị dịpụrụ adịpụ). Ọ bụrụ na ọrịa jalestice na-eme, a ga-akwụsị ịgwọ ya. Ọtụtụ mgbe, mgbaàmà ndị a na-apụ n'anya mgbe ị kwụsịrị ị theụ ọgwụ,
nsogbu nke iku ume: enweghi ike ịhụ ụzọ.

Usoro igodo

Na enweghị mmetụta nke ọgwụgwọ glycemia na-esochi nri, ndị dọkịta depụtara ọgwụ Gliclazide, nke na-achọpụta ọnọdụ nke gland thyroid na ọkwa nke glucose n'ọbara. A na-ewere onodu hypoglycemic n'ụdị maka ọrịa shuga nke ọrịa shuga 2, na contraindicated na ọgwụ insulin. Site na ntuziaka maka iji ọgwụ Glyclazide, ị nwere ike ịchọpụta ozi gbasara njirimara, nsonaazụ yana ọgwụ ọgwụ.

Nkwadebe ọnụ a na-eme n'ọbara, bụ́ nke bụ usoro nke usoro nke abụọ n’ọbara sulfonylurea, nwere ọtụtụ ọgwụ ọgwụ na-agwọ ọrịa. A na-enweta Glyclazide n'ụdị mbadamba 80 mg ma ọ bụ 30 na 60 mg yana mgbapụta agbanwetụ. Ogwu a gosipụtara na ịba uru, ya mere, a na - egosikarị ya iji mee ka glucose ọbara dị ọcha.

Mbadamba ụrọ 30 mg nke Glyclazide nwere okirikiri, dị larịị na-adị ọcha, enwere chamfer, agba ahụ na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke na-acha ọcha (odo ma ọ bụ isi awọ). Usoro ogwu nke 60 mg nọ n'ihe ize ndụ. Ihe na-arụ ọrụ bụ gliclazide. Nhazi nke ọgwụ:

Ihe ngosi maka ojiji

A na-eji ọgwụ Gliclazide mee ihe maka ụdị ọrịa shuga 2 na hyperglycemia. Ceptionnabata bụ nke bara uru ma ọ bụrụ na ọ dịchaghị uru ọgwụgwọ ọgwụ, ụzọ iji belata ndekọ anụ ahụ yana mmega ahụ pụrụ iche. Glyclazide dị irè igbochi nsogbu nke ọrịa shuga nke ọrịa shuga 2: mmepe nke microvascular pathologies (ọnya afọ, infarction myocardial) na nsogbu microcirculatory (retinopathy, nephropathy).

Ntụziaka maka iji Gliclazide

Mkpebi banyere usoro onunu ogwu maka ịbanye na hyperglycemia bụ nke dabere n’usoro nke usoro: afọ, ogo nke ọrịa shuga, yana shuga ọbara tupu iri nri na elekere abụọ gachara. Usoro ọgwụgwọ akwadoro nke mbụ bụ 40 mg na nri. A na-atụ aro ị Thisụ ọgwụ a maka ndị ọrịa niile, gụnyere ndị agadi. Ọgwụ mbụ kwa ụbọchị bụ 80 mg. Ọzọkwa, dabere na parampat, nkezi nke 160 mg kwa ụbọchị. A na-eme ndozi usoro onunu na-eburu n'uche oge izu abụọ kacha nta.

Ihe kacha anabata ike ị nweta bụ - 320 mg. Ọ bụrụ n’ikpebie ị theụ ọgwụ ahụ, ịkwesighi ịba ụba dose ahụ n’echi ya. Usoro ọgwụgwọ maka ndị ọrịa agadi, yana ndị ọrịa nwere ọdịda gbasara akụrụngwa, adịghị iche. Shouldụ ọgwụ ahụ kwesịrị ịchịkwa glucose ọbara iji gbochie hypoglycemia (ịba ụba nke glucose).

Glyclazide MV 30 mg

-Kpụrụ Gliclazide gbanwetụrụ (MV) nke Gliclazide nwere ike ịdị site na 30 ruo 120 mg. N'ikuku na-ewere nri n'ụtụtụ. Ọ bụrụ n ’ịwụsị ọgwụ maka hyperglycemia, amachibidoro ụgwọ ọrụ site na ịbawanye ọgwụ na-esote ụbọchị. A na-eme mkpebi usoro onunu ogwu. Imu mbu bu 30 mg.N'ihe banyere ọdịda nke nsonaazụ ahụ, dose ahụ jiri nwayọ (otu ugboro n'ọnwa) ruru 60, 90 na 120 mg. Enwere ike ịgbakwunye Gliclazide MB yana insulin. Ka anyị chee ngbanwe yiri nke a site na iwere Gliclazide 80 ruo Gilllazide MV 30 mg mgbe oke shuga gachara.

Usoro ire na ebe nchekwa

Ọgwụ a kwesịrị ịchekwa n'ebe gbara ọchịchịrị na-enweghị mmiri na okpomọkụ ọ bụla dị elu karịa ogo 25. Ekwesịrị ichebe Gliclazide site na ụmụaka. Ndụ shelf bụ afọ atọ. Relelị site na ndenye ọgwụ.

Na 1 mbadamba 80 nke mg gliclazide.

Hypromellose, microcrystalline cellulose, magnesium silicon stearate, dioxide, dị ka ihe inyeaka.

Na Mbadamba mbadamba nke Gliclazide MV 30 mg gliclazide.

Mpempe mwepụta

Usoro igodo

Na enweghị mmetụta nke ọgwụgwọ glycemia na-esochi nri, ndị dọkịta depụtara ọgwụ Gliclazide, nke na-achọpụta ọnọdụ nke gland thyroid na ọkwa nke glucose n'ọbara. A na-ewere onodu hypoglycemic n'ụdị maka ọrịa shuga nke ọrịa shuga 2, na contraindicated na ọgwụ insulin. Site na ntuziaka maka iji ọgwụ Glyclazide, ị nwere ike ịchọpụta ozi gbasara njirimara, nsonaazụ yana ọgwụ ọgwụ.

Nkwadebe ọnụ a na-eme n'ọbara, bụ́ nke bụ usoro nke usoro nke abụọ n’ọbara sulfonylurea, nwere ọtụtụ ọgwụ ọgwụ na-agwọ ọrịa. A na-enweta Glyclazide n'ụdị mbadamba 80 mg ma ọ bụ 30 na 60 mg yana mgbapụta agbanwetụ. Ogwu a gosipụtara na ịba uru, ya mere, a na - egosikarị ya iji mee ka glucose ọbara dị ọcha.

Mbadamba ụrọ 30 mg nke Glyclazide nwere okirikiri, dị larịị na-adị ọcha, enwere chamfer, agba ahụ na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke na-acha ọcha (odo ma ọ bụ isi awọ). Usoro ogwu nke 60 mg nọ n'ihe ize ndụ. Ihe na-arụ ọrụ bụ gliclazide. Nhazi nke ọgwụ:

Pharmacodynamics na pharmacokinetics

Ngwá ọrụ na-akpali secretion nke insulin site na pancreas (β-sel) ma na - eme ka profaịlụ ọ gbasoro. A na - eme ka arụ ọrụ nke ọgwụ a dịkwuo ike site na ịbawanye ike nke anụ ahụ na - egbochi akụkụ ahụ, iji belata oge dị n'etiti oriri nri yana mmalite nke nzuzo nke ihe ahụ. N'ihi nchịkwa, ọnụ ọgụgụ kachasị elu nke hyperglycemia mgbe a na -eribelata nri n'ime ndị ọrịa, a na-ahụkarị metabolism metabolism.

Ọgwụ a na -ebelata nrapado platelet, nke a na --ewepụta ọghọm nke thrombosis na thribus nke parietal. Fibrinolytic ọrụ vaskụla na-abawanye na vaskụla permeability normalizes. Glyclazide nwere ike belata cholesterol na ọgwụ na-enweghị ihe mgbochi, na-egbochi ịbanye na atherosclerosis. Ngwongwo dị mkpa bụ ike nke ọgwụ iji belata ike ọbara arịa na adrenaline, iguzogide nchịkọta platelet.

A na-etinye ọgwụ ngwa ngwa na eriri afọ, mgbe nke a gasịrị, plọm plasma na-amalite ịbawanye nwayọ, na-ebute akara kachasị ruo awa 7-12 mgbe nchịkwa. Njikọ nke Gliclazide na protein plasma bụ 95%. Ọnụnọ nri anaghị emetụta usoro oriri nke ngwaahịa a. Metabolism nke ọgwụ na-eme na imeju. Iwepu ọkara ndụ bụ ihe dịka awa iri na abụọ. Iwepu ego na - aputa ihe site na akụrụ n’otu ụdị metabolites.

Ihe ngosi maka ojiji

A na-eji ọgwụ Gliclazide mee ihe maka ụdị ọrịa shuga 2 na hyperglycemia. Ceptionnabata bụ nke bara uru ma ọ bụrụ na ọ dịchaghị uru ọgwụgwọ ọgwụ, ụzọ iji belata ndekọ anụ ahụ yana mmega ahụ pụrụ iche. Glyclazide dị irè igbochi nsogbu nke ọrịa shuga nke ọrịa shuga 2: mmepe nke microvascular pathologies (ọnya afọ, infarction myocardial) na nsogbu microcirculatory (retinopathy, nephropathy).

Ntụziaka maka iji Gliclazide

Mkpebi banyere usoro onunu ogwu maka ịbanye na hyperglycemia bụ nke dabere n’usoro nke usoro: afọ, ogo nke ọrịa shuga, yana shuga ọbara tupu iri nri na elekere abụọ gachara. Usoro ọgwụgwọ akwadoro nke mbụ bụ 40 mg na nri. A na-atụ aro ị Thisụ ọgwụ a maka ndị ọrịa niile, gụnyere ndị agadi. Ọgwụ mbụ kwa ụbọchị bụ 80 mg. Ọzọkwa, dabere na parampat, nkezi nke 160 mg kwa ụbọchị. A na-eme ndozi usoro onunu na-eburu n'uche oge izu abụọ kacha nta.

Ihe kacha anabata ike ị nweta bụ - 320 mg. Ọ bụrụ n’ikpebie ị theụ ọgwụ ahụ, ịkwesighi ịba ụba dose ahụ n’echi ya. Usoro ọgwụgwọ maka ndị ọrịa agadi, yana ndị ọrịa nwere ọdịda gbasara akụrụngwa, adịghị iche. Shouldụ ọgwụ ahụ kwesịrị ịchịkwa glucose ọbara iji gbochie hypoglycemia (ịba ụba nke glucose).

Glyclazide MV 30 mg

-Kpụrụ Gliclazide gbanwetụrụ (MV) nke Gliclazide nwere ike ịdị site na 30 ruo 120 mg. N'ikuku na-ewere nri n'ụtụtụ. Ọ bụrụ n ’ịwụsị ọgwụ maka hyperglycemia, amachibidoro ụgwọ ọrụ site na ịbawanye ọgwụ na-esote ụbọchị. A na-eme mkpebi usoro onunu ogwu. Imu mbu bu 30 mg. N'ihe banyere ọdịda nke nsonaazụ ahụ, dose ahụ jiri nwayọ (otu ugboro n'ọnwa) ruru 60, 90 na 120 mg. Enwere ike ịgbakwunye Gliclazide MB yana insulin. Ka anyị chee ngbanwe yiri nke a site na iwere Gliclazide 80 ruo Gilllazide MV 30 mg mgbe oke shuga gachara.

Mkparịta ụka ọgwụ ọjọọ

Mgbe ị na-ejikọ gliclazide na ọgwụ ndị ọzọ, akpachara anya kwesịrị ịkpachara anya. Iji belata ihe egwu, a ga-atụle ihe ndị a:

• ọgwụ a na - akwalite nsonaazụ anticoagulants, warfarin,
• Miconazole, phenylbutazone, ethanol na-abawanye mmetụta nke ọgwụ ahụ, na-amụba ohere nke hypoglycemia na coma,
• ọgwụ hypoglycemic ndị ọzọ, beta-mgbochi, fluconazole, captopril, cimetidine, sulfonamides, ọgwụ mgbochi anti-mbufụt na-abawanye hypoglycemia,
• Danazole na-abawanye ọrịa mamịrị, Chlorpromazine na-ebelata ihe nzuzo nke insulin, glucocorticosteroids, Salbutamol, Ritodrin na-abawanye glucose ọbara, mmetụta hypoglycemic nke Gliclazide.

Nsonaazụ

N'iji ọgwụ, ndị ọrịa nwere ike ịnwe mmetụta ndị ọzọ. A na-ahụkarị ihe ndị a:

• hypoglycemia, nke eji mara isi ọwụwa, ike ọgwụgwụ, ike ọgwụgwụ na agụụ,
• obi palp,
• arrhythmia, nsogbu ịrị elu, ura, ma ọ bụ ehighị ụra nke ọma,
• ịda mba, ọhụhụ ụzọ, ịma jijiji,
• paresis, dizzness, delirium, cramps,
• bradycardia, ntakwara, coma, ọgbụgbọ,
• jaundice
• mgbochi nke ụmị ọkpụkpụ, mmeghachi omume nfụkasị ahụ,
• erythema
• anaemia, vasculitis, ọrịa imeju.

Dodoụbiga ya ókè

Ihe mgbaàmà nke oke ịdoụ ọgwụ bụ hypoglycemia, ọnwụ nke nsụ, coma. Ọ bụrụ na ọrịa agaghị ada mbà, a ga-enye ya shuga. Mgbe nsogbu ma ọ bụ ihe ọdịdọ mere, ịkwesịrị ịkpọ ụgbọ ihe mberede kpọtara onye ọrịa ozugbo. Maka ọgwụgwọ, a na-achịkwa 50 ml nke 40% dextrose ma ọ bụ glucose na-etinye ume ike. Mgbe ọ gbakechara, a na-enye onye ọrịa ahụ nri n'ụba n'ụdị carbohydrates dị mfe ma dị mfe ngwangwa, a na-enyocha ọnọdụ ahụ ruo ụbọchị abụọ. Ialchọpụta nyocha ma ọ bụrụ na ị doụbiga mmanya ókè anaghị enye nsonaazụ achọrọ, n'ihi na Gliclazide na-ejikọ protein protein.

Ihe ngbanwe

Na ọnụnọ nke hypersensitivity na otu n'ime mmiri ọgwụ ahụ, edeghị ya. Ihe ndi ozo megide ogwu a bu:

• ụdị shuga 1
• hypersensitivity na sulfonylureas ma ọ bụ sulfonamides,
• ọrịa shuga, ketoacidosis, precoma,
• oké ịba ọcha n'anya ma ọ bụ akụrụ ọdịda,
• ojiji nke miconazole,
• afọ ime, lactation,
• afọ ruo afọ 18
• ọrịa shuga,
• ngwakọta na phenylbutazone ma ọ bụ danazole.

Usoro ire na ebe nchekwa

Ọgwụ a kwesịrị ịchekwa n'ebe gbara ọchịchịrị na-enweghị mmiri na okpomọkụ ọ bụla dị elu karịa ogo 25. Ekwesịrị ichebe Gliclazide site na ụmụaka. Ndụ shelf bụ afọ atọ. Relelị site na ndenye ọgwụ.

Na 1 mbadamba 80 nke mg gliclazide.

Hypromellose, microcrystalline cellulose, magnesium silicon stearate, dioxide, dị ka ihe inyeaka.

Na Mbadamba mbadamba nke Gliclazide MV 30 mg gliclazide.

Mpempe mwepụta

Ọnọdụ nchekwa

Bọchị mmebi:
Maka usoro onunu ogwu nke 30 mg, ndu nchekwa ndu bu 1 afọ.
Maka usoro onunu ogwu nke 60 mg, ndu nchekwa bu afọ 2.
Ejila oge emechara ka egosiputara na ngwugwu ahụ.

Mpempe mwepụta

Usoro igodo

Na enweghị mmetụta nke ọgwụgwọ glycemia na-esochi nri, ndị dọkịta depụtara ọgwụ Gliclazide, nke na-achọpụta ọnọdụ nke gland thyroid na ọkwa nke glucose n'ọbara. A na-ewere onodu hypoglycemic n'ụdị maka ọrịa shuga nke ọrịa shuga 2, na contraindicated na ọgwụ insulin. Site na ntuziaka maka iji ọgwụ Glyclazide, ị nwere ike ịchọpụta ozi gbasara njirimara, nsonaazụ yana ọgwụ ọgwụ.

Nkwadebe ọnụ a na-eme n'ọbara, bụ́ nke bụ usoro nke usoro nke abụọ n’ọbara sulfonylurea, nwere ọtụtụ ọgwụ ọgwụ na-agwọ ọrịa. A na-enweta Glyclazide n'ụdị mbadamba 80 mg ma ọ bụ 30 na 60 mg yana mgbapụta agbanwetụ. Ogwu a gosipụtara na ịba uru, ya mere, a na - egosikarị ya iji mee ka glucose ọbara dị ọcha.

Mbadamba ụrọ 30 mg nke Glyclazide nwere okirikiri, dị larịị na-adị ọcha, enwere chamfer, agba ahụ na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke na-acha ọcha (odo ma ọ bụ isi awọ). Usoro ogwu nke 60 mg nọ n'ihe ize ndụ. Ihe na-arụ ọrụ bụ gliclazide. Nhazi nke ọgwụ:

Pharmacodynamics na pharmacokinetics

Ngwá ọrụ na-akpali secretion nke insulin site na pancreas (β-sel) ma na - eme ka profaịlụ ọ gbasoro. A na - eme ka arụ ọrụ nke ọgwụ a dịkwuo ike site na ịbawanye ike nke anụ ahụ na - egbochi akụkụ ahụ, iji belata oge dị n'etiti oriri nri yana mmalite nke nzuzo nke ihe ahụ. N'ihi nchịkwa, ọnụ ọgụgụ kachasị elu nke hyperglycemia mgbe a na -eribelata nri n'ime ndị ọrịa, a na-ahụkarị metabolism metabolism.

Ọgwụ a na -ebelata nrapado platelet, nke a na --ewepụta ọghọm nke thrombosis na thribus nke parietal. Fibrinolytic ọrụ vaskụla na-abawanye na vaskụla permeability normalizes. Glyclazide nwere ike belata cholesterol na ọgwụ na-enweghị ihe mgbochi, na-egbochi ịbanye na atherosclerosis. Ngwongwo dị mkpa bụ ike nke ọgwụ iji belata ike ọbara arịa na adrenaline, iguzogide nchịkọta platelet.

A na-etinye ọgwụ ngwa ngwa na eriri afọ, mgbe nke a gasịrị, plọm plasma na-amalite ịbawanye nwayọ, na-ebute akara kachasị ruo awa 7-12 mgbe nchịkwa. Njikọ nke Gliclazide na protein plasma bụ 95%. Ọnụnọ nri anaghị emetụta usoro oriri nke ngwaahịa a. Metabolism nke ọgwụ na-eme na imeju. Iwepu ọkara ndụ bụ ihe dịka awa iri na abụọ. Iwepu ego na - aputa ihe site na akụrụ n’otu ụdị metabolites.

Ihe ngosi maka ojiji

A na-eji ọgwụ Gliclazide mee ihe maka ụdị ọrịa shuga 2 na hyperglycemia. Ceptionnabata bụ nke bara uru ma ọ bụrụ na ọ dịchaghị uru ọgwụgwọ ọgwụ, ụzọ iji belata ndekọ anụ ahụ yana mmega ahụ pụrụ iche. Glyclazide dị irè igbochi nsogbu nke ọrịa shuga nke ọrịa shuga 2: mmepe nke microvascular pathologies (ọnya afọ, infarction myocardial) na nsogbu microcirculatory (retinopathy, nephropathy).

Ntụziaka maka iji Gliclazide

Mkpebi banyere usoro onunu ogwu maka ịbanye na hyperglycemia bụ nke dabere n’usoro nke usoro: afọ, ogo nke ọrịa shuga, yana shuga ọbara tupu iri nri na elekere abụọ gachara. Usoro ọgwụgwọ akwadoro nke mbụ bụ 40 mg na nri. A na-atụ aro ị Thisụ ọgwụ a maka ndị ọrịa niile, gụnyere ndị agadi. Ọgwụ mbụ kwa ụbọchị bụ 80 mg. Ọzọkwa, dabere na parampat, nkezi nke 160 mg kwa ụbọchị. A na-eme ndozi usoro onunu na-eburu n'uche oge izu abụọ kacha nta.

Ihe kacha anabata ike ị nweta bụ - 320 mg. Ọ bụrụ n’ikpebie ị theụ ọgwụ ahụ, ịkwesighi ịba ụba dose ahụ n’echi ya. Usoro ọgwụgwọ maka ndị ọrịa agadi, yana ndị ọrịa nwere ọdịda gbasara akụrụngwa, adịghị iche. Shouldụ ọgwụ ahụ kwesịrị ịchịkwa glucose ọbara iji gbochie hypoglycemia (ịba ụba nke glucose).

Glyclazide MV 30 mg

-Kpụrụ Gliclazide gbanwetụrụ (MV) nke Gliclazide nwere ike ịdị site na 30 ruo 120 mg. N'ikuku na-ewere nri n'ụtụtụ. Ọ bụrụ n ’ịwụsị ọgwụ maka hyperglycemia, amachibidoro ụgwọ ọrụ site na ịbawanye ọgwụ na-esote ụbọchị. A na-eme mkpebi usoro onunu ogwu. Imu mbu bu 30 mg. N'ihe banyere ọdịda nke nsonaazụ ahụ, dose ahụ jiri nwayọ (otu ugboro n'ọnwa) ruru 60, 90 na 120 mg. Enwere ike ịgbakwunye Gliclazide MB yana insulin. Ka anyị chee ngbanwe yiri nke a site na iwere Gliclazide 80 ruo Gilllazide MV 30 mg mgbe oke shuga gachara.

Mkparịta ụka ọgwụ ọjọọ

Mgbe ị na-ejikọ gliclazide na ọgwụ ndị ọzọ, akpachara anya kwesịrị ịkpachara anya. Iji belata ihe egwu, a ga-atụle ihe ndị a:

• ọgwụ a na - akwalite nsonaazụ anticoagulants, warfarin,
• Miconazole, phenylbutazone, ethanol na-abawanye mmetụta nke ọgwụ ahụ, na-amụba ohere nke hypoglycemia na coma,
• ọgwụ hypoglycemic ndị ọzọ, beta-mgbochi, fluconazole, captopril, cimetidine, sulfonamides, ọgwụ mgbochi anti-mbufụt na-abawanye hypoglycemia,
• Danazole na-abawanye ọrịa mamịrị, Chlorpromazine na-ebelata ihe nzuzo nke insulin, glucocorticosteroids, Salbutamol, Ritodrin na-abawanye glucose ọbara, mmetụta hypoglycemic nke Gliclazide.

Nsonaazụ

N'iji ọgwụ, ndị ọrịa nwere ike ịnwe mmetụta ndị ọzọ. A na-ahụkarị ihe ndị a:

• hypoglycemia, nke eji mara isi ọwụwa, ike ọgwụgwụ, ike ọgwụgwụ na agụụ,
• obi palp,
• arrhythmia, nsogbu ịrị elu, ura, ma ọ bụ ehighị ụra nke ọma,
• ịda mba, ọhụhụ ụzọ, ịma jijiji,
• paresis, dizzness, delirium, cramps,
• bradycardia, ntakwara, coma, ọgbụgbọ,
• jaundice
• mgbochi nke ụmị ọkpụkpụ, mmeghachi omume nfụkasị ahụ,
• erythema
• anaemia, vasculitis, ọrịa imeju.

Dodoụbiga ya ókè

Ihe mgbaàmà nke oke ịdoụ ọgwụ bụ hypoglycemia, ọnwụ nke nsụ, coma. Ọ bụrụ na ọrịa agaghị ada mbà, a ga-enye ya shuga. Mgbe nsogbu ma ọ bụ ihe ọdịdọ mere, ịkwesịrị ịkpọ ụgbọ ihe mberede kpọtara onye ọrịa ozugbo. Maka ọgwụgwọ, a na-achịkwa 50 ml nke 40% dextrose ma ọ bụ glucose na-etinye ume ike. Mgbe ọ gbakechara, a na-enye onye ọrịa ahụ nri n'ụba n'ụdị carbohydrates dị mfe ma dị mfe ngwangwa, a na-enyocha ọnọdụ ahụ ruo ụbọchị abụọ. Ialchọpụta nyocha ma ọ bụrụ na ị doụbiga mmanya ókè anaghị enye nsonaazụ achọrọ, n'ihi na Gliclazide na-ejikọ protein protein.

Ihe ngbanwe

Na ọnụnọ nke hypersensitivity na otu n'ime mmiri ọgwụ ahụ, edeghị ya. Ihe ndi ozo megide ogwu a bu:

• ụdị shuga 1
• hypersensitivity na sulfonylureas ma ọ bụ sulfonamides,
• ọrịa shuga, ketoacidosis, precoma,
• oké ịba ọcha n'anya ma ọ bụ akụrụ ọdịda,
• ojiji nke miconazole,
• afọ ime, lactation,
• afọ ruo afọ 18
• ọrịa shuga,
• ngwakọta na phenylbutazone ma ọ bụ danazole.

Usoro ire na ebe nchekwa

Ọgwụ a kwesịrị ịchekwa n'ebe gbara ọchịchịrị na-enweghị mmiri na okpomọkụ ọ bụla dị elu karịa ogo 25. Ekwesịrị ichebe Gliclazide site na ụmụaka. Ndụ shelf bụ afọ atọ. Relelị site na ndenye ọgwụ.

Na 1 mbadamba 80 nke mg gliclazide.

Hypromellose, microcrystalline cellulose, magnesium silicon stearate, dioxide, dị ka ihe inyeaka.

Na Mbadamba mbadamba nke Gliclazide MV 30 mg gliclazide.

Mpempe mwepụta

Omume ọgwụ

Pharmacodynamics na pharmacokinetics

Mlọ ọgwụ

Ọrịa hypoglycemic, nke bụ usoro nke usoro oyuche sulfonylurea II. Na-akwalite mmepụta nke insulin site na mkpụrụ ndụ-and-ma weghachi profaịlụ nke ahụ. Theakingụ ọgwụ ahụ na -ebelata oge site na oge iri nri ruo na mmalite insulin insulin, ebe ọ na-eweghachi usoro mbu (nke mbụ) ma buliekwa agba nke abụọ. Na -ebelata agbam ume kachasị elu mgbe ị risịrị nri. Ọ na - eme ka anụ ahụ mara insulin.
Na mgbakwunye, ọ na-ebelata ihe egwu. thrombosissite na-ebelata mkpọchi na nrapado ọgụgụ plateletna - eweghachi ọrịa anụ ahụ parietal fibrinolysisna - eme ka microcirculation dịkwuo mma. Mmetụta a dị mkpa n'ihi na ọ na-ebelata ohere nke nnukwu nsogbu - yana microangiopathies. Site na nephropathy mamịrị, enwere ịbelata n'oge ọgwụgwọ ọgwụ a. Ọ na - egbochi mmepe nke atherosclerosis, ebe ọ nwere ihe anti-atherogenic.

Njirimara nke usoro onunu ogwu Gliclazide MV nye ịta ahụ ọgwụgwọ na njikwa ọkwa glucose dị mma n'ime awa iri abụọ na anọ.

Mlọ ọgwụ

N’itinye ngwa ngwa n’ime ogwara nri, ogo nke nnabata dị elu. A na-ekpebi itinye uche kachasị (mgbe ewere 80 mg) mgbe awa 4. A na-ekwurita mkparịta ụka na protein na ihe dịka 97%. A na-enweta ntinye uche ịlele mgbe nchịkwa gachara ụbọchị abụọ. Metabolized n'ime imeju na-metabolites 8. Ihe ruru 70% bụ akụrụ, akwara - 12%. Mwepu ọkara ndụ nke gliclazide nkịtị bụ awa 8, agbatịwo ruo awa 20.

Ihe ngosi maka ojiji

• mgbochi nke nsogbu (nephropathy, ) nke na-abụghị insulin,
• IIdị II.

Ihe ngbanwe

• shuga na-arịa insulin na-arịa ọrịa shuga mellitus,
• ketoacidosis,
• oke akụrụ gbasara akụrụ / imeju,
• na-arịa ọrịa lactose innerance, ọrịa malabsorption,
• n’otu oge nnabata na ma ọ bụ Phenylbutazone,
• afọ ruo afọ 18
• hypersensitivity
• ime, lactation.

Eji nlezianya debe ya na agadi, ya na nri adighi adighi nma. hypopituitarismsiri ike Ọrịa ọrịa obi Ischemicwee kpọọ adrenal ezughi okeogologo oge ọgwụgwọ glucocorticosteroids.

Nsonaazụ

• ọgbụgbọ, vomiting, afọ mgbu,
• thrombocytopenia, erythropenia, , hemolytic anaemia,
• nfụkasị vasculitis,
• ọnya ọnyá, itching,
• imeju imeju,
• mmebi anya
• hypoglycemia(bụrụ na ị doụbiga ya ókè).

Glyclazide, ntuziaka maka ojiji (Usoro na usoro onunu ogwu)

Mbadamba nke Glyclazide N'usoro ọgwụ mbido 80 kwa ụbọchị, ugboro 2 n’ụbọchị 30 nkeji tupu nri. N’ọdị n’ihu, a na-agbazi ọgwụ a na-agbaso, kwa ụbọchị ị na-eri kwa ụbọchị bụ 160 mg, ma kacha bụ 320 mg. Mbadamba ụrọ Glyclazide MB nwere ike ịhụ mbadamba mbugharị oge niile. Ọ bụ dọkịta ga-ekpebi ihe ga-ekwe omume ma dochie ya na ọgwụ a.

Glyclazide MB 30 mg iri oge 1 n’oge nri ụtụtụ. A na-amalite ịgbanwe ọgwụ mgbe izu 2 gachara. Ọ nwere ike ịbụ 90 -120 mg.

Ọ bụrụ na ọgwụ gị riri gị ọgwụ, ị gaghị anara ya okpukpu abụọ. Mgbe ị ga-eji nke a dochie ọgwụ belata shuga ọzọ, oge mgbanwe agaghị achọ ya - ha ga - ebido were ya echi. Ikekwe ngwakọta na biguanides,, alfa glucosidase inhibitors. N'ime ogo dị nwayọ na n'ọdịdị, a na-ede ya otu usoro onunu ogwu. N'ime ndị ọrịa nwere ọrịa hypoglycemia, a na-eji ntakịrị ọgwụ.

Dodoụbiga ya ókè

A na - egosipụta oke nrịba ama site na mgbaàmà hypoglycemia: isi ọwụwa, ike ọgwụgwụ, adịghị ike siri ike, ịsụgharị, palpitations, ọbara mgbali elu, arrhythmiairo ụra mkpasu iweiwe, oke iwe, mmeghachi omume na-egbu oge, ọhụụ na-enweghị isi na okwu, ịma jijijianya ntughari ogwe, bradycardiaọnwụ nke mmụọ.

Na agafeghị oke hypoglycemiana-enweghị mmụọ ịta ahụhụ, belata dose nke ọgwụ ma ọ bụ nwekwuo ego nke carbohydrates na-enye nri.

Na ọnọdụ hypoglycemic siri ike, ịbanye n'ụlọ ọgwụ na enyemaka dị mkpa: iv 50 ml nke 20 glucose 20-30% gluu, mgbe ahụ 10% dextrose ma ọ bụ glucose na-asọpụta. N'ime ụbọchị abụọ, a na-enyocha ọkwa glucose. Dialysis adighi ike.

Mmekorita

Ojiji nke ndị na - egbochi beta na - ahọrọ ihe a na - ebute nsogbu ahụ hypoglycemia.

Mgbe itinye akwụkwọ Acarboseakara mmado hypoglycemic akara.

Mgbe ị na-eji GCS (gụnyere ụdị ngwa ọzọ). mgbochi ego, diuretics, estrogenna progestins., na-ebelata mmetụta belata shuga nke ọgwụ.

Usoro ahia

Ọnọdụ nchekwa

Mgbe ọ bụla okpomoku adịghị ihe karịrị 25 C.

Nyocha banyere Gliclazide

Ka ọ dị ugbu a, usoro eji eme ihe n'ọtụtụ ebe.ọgbọ nke abụọ sulfonylureas. Ọgbọ a ọgwụ adịghị yikarị ịkpata nsonaazụ.

Otu njiri mara nke ọgwụ ahụ bụ na na mgbanwe metabolic ọtụtụ metabolites, na otu n’ime ha nwere mmetụta dị ukwuu na microcirculation. Ọtụtụ ọmụmụ egosila na enwere ihe ọghọm nke nsogbu microvascular (retinopathyna nephropathy) na ọgwụgwọ gliclazide. Ogo-ebelata angiopathy, oriri na-edozi ahụ na-adịwanye mma, na-apụ n'anya vaskụla stasis. Ọ bụ ya mere e ji nye ya ọgwụ maka nsogbu ọrịa shuga mellitus (angiopathy, nephropathyna mbu nwa akuko okpu, retinopathies) a na-akọkwara nke a site n'aka ndị ọrịa bufere nke a, zigara ya ị takingụ ọgwụ a.

Ọtụtụ na-ekwusi ike na a ga-ewere mbadamba mgbe nri ụtụtụ gasịrị, nke nwere carbohydrates zuru oke, agụụ maka ụbọchị adịghị anabata. Ma ọ bụghị ya, megide ụdị nri obere kalori na mgbe ọ gbasịrị nnukwu ahụ, enwere ike mmepe hypoglycemia. Site na nrụgide anụ ahụ, ọ dị mkpa ịgbanwe dose nke ọgwụ. Mgbe ha drinkingụsịrị mmanya, ụfọdụ ụfọdụ nwekwara ọnọdụ nke ịba ụba.

Ndị okenye na-elebara ọgwụ hypoglycemic anya karịsịa, ebe ọ bụ na ihe egwu ha nwere ịba ụba hypoglycemia mụbara. Na njikọ a, ọ kaara ha mma iji ọgwụ adịghị eme ihe (ọ dị mma gliclazide).
Ndị ọrịa na-achọpụta na nyocha ha banyere ịdị mma nke iji mbadamba ihe eji emegharị emezi: ha na-eme nwayọ na nha, yabụ a na-eji ya otu ugboro n'ụbọchị. Na mgbakwunye, ogo ya dị irè ji okpukpu abụọ dị ala karịa otu esi eme ya gliclazide.

Otu n'ime ọrịa a na-ahụkarị maka endocrine bụ ọrịa shuga. Imirikiti ndị ọrịa nwere nchọpụta a na-arịa ụdị ọrịa nke abụọ. Ọrịa ahụ chọrọ ọgwụgwọ na ọgwụ oge niile. Ọgwụ "Gliclazide" nwere ike ịkwalite mmepụta insulin n'ime ahụ. Analogues nke ọgwụ nwere ike ịnwe otu ụdị nke ọgwụgwọ ọgwụgwọ ma ọ bụ otu ihe mejupụtara. Dọkịta na-aga ahụ kwesịrị ịhọrọ nke ọzọ maka ọgwụ ọgwụ mbụ.

Ozi izugbe

Akwụkwọ ikike ndebanye aha maka Gliclazide MV bụ nke ụlọ ọrụ Russia Atoll LLC nyere. Ọgwụ dị n'okpuru nkwekọrịta ahụ bụ ụlọ ọrụ ọgwụ Samara Ozone mepụtara.Ọ na-emepụta ma na-etinye mbadamba, ma na-ejikwa njikwa ha. Enweghị ike ịkpọ Gliclazide MV kpamkpam ọgwụ ụlọ, ebe ọ bụ na azụrụ ọgwụ maka ya (otu glyclazide) na China. N’agbanyeghi nke a, enweghi ihe ọjọọ nwere ike ikwu maka ịdị mma nke ọgwụ. Dabere na ndị na-arịa ọrịa shuga, ọ dịghị njọ karịa French Diabeton nwere otu ihe mejupụtara.

Nkpirisi okwu MV na aha ogwu n’egosi na ihe di n’ime ya bu ihe eweputara, ma obu ogologo oge. Glyclazide na-apụta na mbadamba ụrọ n'oge kwesịrị ekwesị na ebe kwesịrị ekwesị, nke na-ahụ na ọ banyeghị n'ọbara ozugbo, mana n'obere akụkụ. N'ihi nke a, a na-ebelata ihe ize ndụ nke mmetụta ndị na-adịghị mma, enwere ike ị drugụ ọgwụ ahụ obere oge. Ọ bụrụ na emebi iwu nke mbadamba ihe, ogologo ọrụ ya ga-efu, yabụ, ntuziaka maka ojiji adịghị atụ aro ka ibepu ya .

A gụnyere Glyclazide na listi ọgwụ ndị dị mkpa, yabụ endocrinologists nwere ohere iji nye ya ndị ọrịa shuga n'efu. Ọtụtụ mgbe, dị ka ọgwụ siri kwuo, ọ bụ MV Gliclazide ụlọ bụ analog nke Diabeton mbụ.

Ọrịa shuga na oke nrụgide ga-abụ ihe mgbe ochie

Ọrịa shuga bụ ihe na-akpata ihe fọrọ nke nta ka ọ bụrụ 80% nke ọrịa strok na mgbatị niile. 7 n’ime mmadụ 10 n’ime mmadụ na-anwụ n’ihi akwara mkpụrụobi ma ọ bụ ụbụrụ nwere oghere. N'ihe fọrọ nke nta ka ọ bụrụ okwu niile, ihe kpatara njedebe a dị oke egwu bụ otu - shuga dị n'ọbara.

Enwere ike ịkwatu shuga, ma ọ bụghị. Mana nke a anaghị agwọ ọrịa ahụ n'onwe ya, kama ọ na - enyere aka ịlụ ọgụ nyocha, ọ bụghị ihe kpatara ọrịa ahụ.

Naanị ọgwụ akwadoro maka ọrịa shuga na ndị endocrinologists jiri rụọ ọrụ ha bụ Ji Dao Diabetes Adhesive.

Ofgwọ ọgwụ ọfụma, gbakọrọ dịka usoro ọkọlọtọ (ọnụọgụ ndị ọrịa nwetụtara ọnụọgụ ndị ọrịa nọ n’otu narị mmadụ 100 e si nweta ọgwụgwọ) bụ:

• Normalization shuga - 95%
• Mwepu nke akwara mbufụt - 70%
• Mwepu nke obi ike - 90%
• Bibie ọbara mgbali elu - 92%
• Ime ka ubochi di elu, meghari ura n'abali - 97%

Ndị na-emepụta Ji Dao abụghị nzukọ azụmahịa, steeti na-akwụkwa ya ụgwọ. Ya mere, ugbu a onye obibi ọ bụla nwere ohere ịnweta ọgwụ ahụ na mbelata 50%.

Kedu ka ọgwụ si arụ ọrụ?

All gliclazide tọrọ atọ na ntupo na-abanye n'ime ọbara ma kegide ya na protein ya. Nọmalị, glucose na-abanye n’ime mkpụrụ ndụ beta ma na-akpali ndị na-anabata ndị pụrụ iche nke na-akpali ntọhapụ nke insulin. Glyclazide na-arụ ọrụ site n'otu ụkpụrụ ahụ, na-akpalite njikọta nke homonụ.

Ọ bụghị nanị mmetụta MV Glyclazide na-arụpụta na-emepụta insulin. Ọgwụ nwere ike:

1. Belata insulin iguzogide. A na-ahụ nsonaazụ kachasị mma (ịmụba insulin na-abawanye site na 35%) na anụ ahụ.
2. Belata mkpụkọ glucose site na umeji, si otu a na-ahụ ọ̀ha oke ibu ọnụ ya.
3. Na-egbochi egbochi mkpụkọ ọbara.
4. Na-akpali njikọ nke nitric oxide, nke a na-etinye aka na ịchịkwa nrụgide, belata mbufụt, ma melite inye anụ ahụ n’akụkụ anụ ahụ.
5. Na-arụ ọrụ dịka antioxidant.

Ntụziaka zuru ezu maka ojiji

Dika ntuziaka ulo ogwu nke Health nke Russia Federation siri kwuo, ekwesiri inye gliclazide iji mee ka insulin na-enyocha ya. N'ụzọ ezi uche dị na ya, a ga-enyocha enweghị mmezu nke onwe ya site na nyocha nke onye ọrịa. Dabere na nyocha, nke a anaghị eme mgbe niile. Ndị na-agwọ ọrịa na endocrinologists depụtara ọgwụ "site na anya". N’ihi ya, ihe karịrị insulin chọrọ ya bụ nke zoro ezo, onye ọrịa ahụ na-achọ iri nri mgbe niile, ibu ya na-eji nwayọọ nwayọọ na-abawanye, ụgwọ maka ọrịa shuga adịghịkwa ezu. Na mgbakwunye, mkpụrụ ndụ beta nke nwere ụdị ọrụ a na-ebibi ngwa ngwa, nke pụtara na ọrịa ahụ na-aga ọkwa nke ọzọ.

Esi zere ụdị nsonazụ ndị a:

1. Bido nrube isi na nri nri ndi oria n’ile (ndi okacha amara nke carbohydrates bu ndi dibia bekee ma obu onye ọrịa n’onwe ya dika glycemia).
2. Cemalite mmeghari nke nọ n'ọrụ kwa ụbọchị.
3. Na-atụkwa ibu dị ka o kwesịrị. Abụba gabigara ókè na-eme ka ọrịa shuga ghara ịka njọ.
4. Ụọ ma ọ bụ ihe atụ ya. Ogo kachasị mma bụ 2000 mg.

Ma naanị ma ọ bụrụ na usoro ndị a ezughi maka shuga nkịtị, ị nwere ike iche maka gliclazide. Tupu ịmalite ọgwụgwọ, ọ bara uru ịnwale maka ma ọ bụ ijide n'aka na njikọ nke homonụ ahụ nwere nsogbu ọfụma.

Mgbe glycated haemoglobin dị elu karịa 8.5%, enwere ike inye MV Gliclazide tinyere nri na metformin nwa oge, ruo mgbe a ga-akwụghachi ọrịa shuga ume. Mgbe nke ahụ gasịrị, a na-ekpebi okwu banyere ịhapụ ọgwụ iji n'otu n'otu.

Etu ị ga-esi mee n’oge afọ ime

Ntụziaka maka iji gbochie ọgwụgwọ na Gliclazide n'oge ime na lact. Dabere na nhazi FDA, ọgwụ a bụ nke klas C. Nke a pụtara na ọ nwere ike imetụta mmepe nke nwa ebu n’afọ, mana anaghị akpata ọgbụgba. Gliclazide dị mma iji dochie ọgwụ insulin tupu ime ime, n'ọnọdụ ndị dị oke njọ - na mmalite.

Anwalebeghị ohere ị ofụ nwa nwere gliclazide. Enwere ihe akaebe na nhazi sulfonylurea nwere ike ịbanye na mmiri ara ehi ma kpatara hypoglycemia n'ime ụmụ aka, yabụ machibidoro ojiji ha n'oge a kapachara iwu.

Dọkịta nke Sciences Medical, Isi nke Institute of Diabetology - Tatyana Yakovleva

M na-amụ ọrịa shuga kemgbe ọtụtụ afọ. Ọ na-atụ ụjọ mgbe ọtụtụ mmadụ nwụrụ, nweekwa nkwarụ karịa n'ihi ọrịa shuga.

Emere m ngwa ngwa izisa ozi ọma - Endocrinological Research Center nke Russian Academy of Medical Sciences jisiri ike mepụta ọgwụ na-agwọ ọrịa shuga mellitus kpamkpam. N'oge a, ịdị irè nke ọgwụ a na-eru nso 98%.

Ozi ọma ọzọ: Ministri Ahụike echekwaala maka mmemme pụrụ iche nke na-akwụ ụgwọ ọgwụ dị elu. Na Russia, ndị ọrịa mamịrị ruo Eprel 22 (yana idobe) nwere ike inweta ya - Naanị 147 rubles!

Mmetụta akụkụ na ị andụbiga mmanya ókè

Mmetụta kachasị njọ nke MV Glyclazide bụ hypoglycemia. Ọ na - apụta mgbe mmepụta insulin karịrị ihe achọrọ maka ya. Ihe kpatara ya nwere ike bụrụ ịdoụ ọgwụ ọalụalụ na mberede, ịpụ nri ma ọ bụ enweghị carbohydrates dị na ya, yana oke mmega ahụ. Ọzọkwa, ịdalata shuga nwere ike ime ka mkpokọta gliclazide n'ime ọbara n'ihi akụrụ na akụrụ nke imeju, mmụba nke ọrụ insulin na ụfọdụ ọrịa endocrine. Dabere na nyocha, na ọgwụgwọ nke sulfonylureas na hypoglycemia, ihe fọrọ nke nta ka ọ bụrụ ndị ọrịa mamịrị na-eche ihu. Enwere ike iwepụ ọtụtụ shuga na oge dị mfe.

Dịka iwu, hypoglycemia jikọtara ya na akara akara: oke agụụ, oke nke oke, nsogbu, adịghị ike. Patientsfọdụ ndị ọrịa jiri nwayọ kwụsị inwe mmetụta ndị a, afọ shuga ha na-etinye ndụ n'ihe egwu. Ha chọrọ nchịkwa glucose ugboro ugboro, gụnyere n'abalị, ma ọ bụ bufee ya na mbadamba shuga ndị ọzọ na-enweghị mmetụta dị otú ahụ.

A na-enyocha ihe ize ndụ nke omume ndị ọzọ na-achọghị na Gliclazide dị ka ọ na-adịghị ahụkebe. Omume:

• nsogbu digestive n'ụdị ọgbụgbọ, mmegharị afọ, ma ọ bụ afọ ọsịsa. Nwere ike belata ha site na ị Gụ Glyclazide n'oge nri kachasị ọkụ,
• akpụkpọ ahụ, ọ na-adịkarị n'ụdị ihe ọkụ ọkụ na-eso ya na itching,
• mbelata platelet, sel ọbara ọbara, sel ọbara. Ihe mejupụtara ọbara ahụ ga-alaghachi na nke ya mgbe ekpochasịrị Gliclazide
• mmụba nwa oge na ọrụ nke enzymes imeju.

Onye glyclazide MV na-contraindicated

Kedu ihe aga-edochi ya

Russian gliclazide bụ ọgwụ dị ọnụ ala, mana kama ịgwọ ọrịa dị elu, ọnụ ahịa nke ịchekwa Gliclazide MV (30 mg, 60 nkeji) ruru 150 rubles. Dochie ya na analogues bụ naanị ma ọ bụrụ na ereghị mbadamba ndị mbụ.

Ogwu mbu bu ogwu ndi ozo nwere otu mebere, tinyere Gliclazide MV - ihe omimi, ma obu okike. Ọnụ ego Diabeton ji ihe dị ka okpukpu abụọ dị elu karịa mkpụrụ ndụ ihe nketa ya.

Glyclazide MV analogues na ndị nọchiri aha Rọshịa (a na-egosi nkwadebe ntọhapụ gbanwetụrụ).

• Glyclazide-SZ nke Severnaya Zvezda CJSC mepụtara.
• Golda MV, Pharmasintez-Tyumen,
• Gliclazide Canon sitere na Mmepụta Canonpharm,
• Glyclazide MV Pharmstandard, Pharmstandard-Tomskkhimfarm,
• Diabetalong, onye na-emepụta MS-Vita,
• Gliklada, Krka,
• Glidiab MV nke Akrikhin,
• Diabefarm MV Pharmacor Production.

Ọnụahịa nke analogues bụ 120-150 rubles kwa ngwugwu. Gliklada mere na Slovenia bụ ọgwụ kachasị ọnụ site na ndepụta a, otu mkpọ na-efu ihe dịka 250 rubles.

Aha ahia nkwadebe: Glyclazide-AKOS

Otu na-ere ọgwụ:

Koodu ATX: A10VB09

Ihe ogwu ogwu:
Glyclazide bụ ọgwụ ọnụ nke hypoglycemic nke a na-enweta site na sulfonylureas nke ọgbọ nke abụọ. Ọ na - akpali sel nke insulin na - eme ka mmiri ọgwụ insulin, na - eme ka insulin-secretory mmetụta nke glucose dị, ma na - eme ka ọsịkwa nke anụ ahụ dị na insulin. Na-akpali ọrụ nke enzymes intracellular - muscle glycogen synthetase. Na-ebelata obere oge site na nri ruo na mmalite nke insulin insulin. Ọ na - eweghachi mmiri ọgbụgba mbụ nke insulin (n'adịghị ka ihe ndị ọzọ sitere na sulfonylurea, nke nwere mmetụta tumadi n'oge ọkwa nke abụọ nke nzuzo). Na-ebelata mmụba glucose postprandial. Na mgbakwunye na emetụta metabolism metabolism, ọ na - eme ka microcirculation dịkwuo mma: ọ na - ebelata platelet na nchịkọta, na - egbochi vaskụla permeability, na - egbochi mmepe nke microthrombosis na atherosclerosis, ma na - eweghachi usoro nke physiological parietal fibrinolysis. Na-ebelata uche nke ndị na-anabata vaskụla na epinephrine. Na-eme ka mmepe nke ọrịa mamịrị nke ọrịa mamịrị na -akwụkọ nke ukwuu. Site na nephropathy ọrịa mamịrị na iji ogologo oge, ọ na-akpata mbelata dị ukwuu na proteinuria. Ọ dịghị ebute mmụba n’arụ ahụ, ebe ọ nwere mmetụta kachasị na mbido insulin insulin ma ghara bute hyperinsulinemia, na-eme ka mbelata oke ahụ n'ahụ ndị ọrịa buru ibu, na-agbaso nri kwesịrị ekwesị. Ọ nwere ihe antiatherogenic, na-ebelata mkpokọta cholesterol n'ime ọbara.

Mlọ ọgwụ:
Mgbe nchịkwa ọnụ gasịrị, ọ na-etinye obi gị dum na eriri afọ. Idopu ihe n’ulo di elu. Mgbe nchịkwa ọnụ nke 80 mg, a na-enweta ntinye kachasị na ọbara (2.2-8 μg / ml) mgbe ihe dị ka awa anọ gasịrị, mgbe nchịkwa 40 mg kachasị nke ọbara (2-3 μg / ml) na-enweta na awa 2-3. Ihe nchebe plasma - 85-97%, olu nkesa - 0.35 l / n'arọ. A na-atụnye ịta ahụhụ dị na ọbara mgbe ụbọchị abụọ gachara. A na-agakọ ya na imeju, imeju nke metabolites asatọ. Ọnụ ọgụgụ nke metabolite bụ isi nke achọtara n'ọbara bụ 2-3% nke ngụkọta ọgwụ a takenụrụ, ọ nweghị mmetụta hypoglycemic, mana ọ na - eme ka microcirculation dịkwuo mma. Ọ bụ akụrụ na - 70% n'ụdị metabolites, erughị 1% n'ụdị agbanweghị, site na eriri afọ - 12% n'ụdị metabolites.Iwepu ọkara ndụ na-eme awa 8-20.

Ihe ngosi maka ojiji
Elldị shuga abụọ nke ọrịa mellitus na ndị okenye jikọtara ya na usoro ọgwụgwọ nri na mmega ahụ na-arụ ọrụ nke oke na nke ikpeazụ anaghị arụ ọrụ.

Ihe ngbanwe
- hypersensitivity na ọgwụ,
- ọrịa shuga mellitus ụdị 1,
- mamịrị ketoacidosis, ọrịa mamịrị, ụkwara ume ọkụ,
- mmiri ọgwụ hyperosmolar,
nnukwu ịba ọcha n'anya na / ma ọ bụ akụrụ ọdịda,
- nnukwu ihe ọgbụgba, oke ọkụ, mmerụ ahụ na ọnọdụ ndị ọzọ chọrọ insulin insulin,
- mgbochi eriri afọ, paresis nke afọ,
- onodu ojoo nke nri nri, uto nke hypoglycemia (oria na-efe efe),
- leukopenia,
- Oge ime, oge inye ara.

Jiri nlezianya Edere (mkpa iji nlezianya na nleba anya na ịhọrọ dose) maka ọrịa febrile, ịhoụ mmanya na ọrịa thyroid (yana arụrụ ọrụ).

Usoro onunu ogwu na nhazi A na-edobe usoro ọgwụ ahụ n'otu n'otu, dabere na afọ onye ọrịa, ngosipụta ụlọ ọgwụ nke ọrịa ahụ na ọkwa glucose na-ebu ọnụ na awa 2 mgbe iri nri. Ọgwụ mbụ kwa ụbọchị bụ 80 mg, nkezi kwa ụbọchị bụ 160 mg, yana kacha ụbọchị kwa ụbọchị bụ 320 mg. Ọgwụ a na-a drugụ ọgwụ Glyclazide-AKOS ugboro abụọ n'ụbọchị (n'ụtụtụ na mgbede) nkeji iri atọ ruo iri isii tupu iri nri.

Hypoglycemia (n'ihe banyere mmebi nke usoro dosing na nri ezughi oke): isi ọwụwa, mmetụta nke ike ọgwụgwụ, agụụ, ọsụsọ, ike dị nkọ, oke iwe, nchekasị, ahụ erughị ala, inattention, enweghi ike itinye uche na mmeghachi omume na-egbu oge, ịda mba, enweghi ike ịhụ ụzọ, aphasia, jijiji, enweghị enyemaka, ọgba aghara, nkụda mmụọ, ọnwụ nke njide onwe onye, ​​nchekasị, ihe nhụjuanya, hyperomnia, ọnwụ nke iku ume, enweghị ume, bradycardia, palpitations.

Site na nri digestive: dyspepsia (ọgbụgbọ, afọ ọsịsa, mmetụta nke ịda oke na epigastrium), anorexia - ogo na-ebelata mgbe ewere nri, ọrụ imeju na-egbu (cholestatic jaundice, ụba ọrụ nke transminases "imeju").

Site na akụkụ ahụ dị na hemopoietic: anaemia, thrombocytopenia, leukopenia.

Mmeghachi omume nfụkasị ahụ : pruritus, urticaria, maculopapular rash.

Dodoụbiga ya ókè
Site na ịdoụbiga mmanya ókè, enwere ike ịba hypoglycemia, ruo mmepe nke hypoglycemic coma. Ọgwụ: Ọ bụrụ na onye ọrịa ahụ amatacha, were ike carbohydrates (shuga) n’ime ahụ ngwa ngwa, na mwepụ nke mmụọ, 40% dextrose (glucose) na-agbanye mgbanye ọbara, 1-2 mg nke glucagon intramuscularly. Mgbe ọ nwetasịrị onwe ya, a ga-enyerịrị onye ọrịa ahụ nri nwere nnukwu carbohydrates na-adị ngwa ngwa (iji zere ịmalite ịmalite hypoglycemia). Na ọrịa ụbụrụ, mannitol na dexamethasone.

Mmekọrịta na ọgwụ ndị ọzọ
Ndị na-egbochi enzyme angiotensin-na-agbanwe (captopril, enalapril), ndị na-anabata H2-histamine blockers (cimetidine), ọgwụ antifungal (miconazole, fluconazole), ọgwụ mgbochi na-abụghị steroidal (phenylbutazonefiburate, indomethanone) na-abawanye hypogly (ethionamide), salicylates, anticoagulants coumarin na-apụtakarị, anabolic steroid, beta-blockers, cyclophosphamide, chloramphenicol, monoaminoox inhibitors. idons, sulfonamides na-arụ ọrụ ogologo oge, fenfluramine, fluoxetine, pentoxifylline, guanethidine, theophylline, ọgwụ mgbochi tubular, reserpine, bromocriptine, viopyramide, pyridoxine, allopurinol, ethanol na ọgwụ ethanol nwere, yana ọgwụ ndị ọzọ.
Werang hypoglycemic effect of gliclazide barbiturates, glucocorticosteroids, sympathomimetics (epinephrine, clonidine, ritodrine, salbutamol, terbutaline), phenytoin, ndị na-egbochi ọwa klọọkụịlị, ikuku carbonic anhydrase inhibitors, diaetaregega , diazoxide, isoniazid, morphine, glucagon, rifampicin, homonụ thyroid, nnu nke lithium, na oke ọnụọgụ - nicotinic acid, chlorpromazine, estrogens na ọgwụ mgbochi mgbochi nke nwere ha.
Mgbe gị na ethanol na-emekọ ihe, mmeghachi omume disulfiram ga-ekwe omume. Glyclazide na-abawanye ohere nke ventricular extrasystole mgbe ị na-ewere glycosides cardiac.
Beta-blockers, clonidine, reserpine, guanethidine nwere ike kpuchie ngosipụta nke hypoglycemia. Ọgwụ ndị na-egbochi hematopoiesis ụmị ọkpụkpụ na-abawanye ihe ize ndụ nke myelosuppression.

Ntụziaka pụrụ iche
A na-eme ọgwụgwọ na ọgwụ Glyclazide-AKOS na ngwakọta nke obere kalori nwere obere carbohydrates. Ọ dị mkpa ịdị na-enyocha ọdịnaya glucose na ọbara mgbe niile na afọ efu na mgbe ị gachara nri. N'ihe banyere nnukwu ịwa ahụ na mmerụ ahụ, oke ọkụ, ọrịa na-efe efe na ọrịa febrile, ọ dị mkpa ịtụle ekwe omume iji nkwadebe insulin.
Ọ dị mkpa ịdọ ndị ọrịa aka na ntị banyere ịba ụba nke hypoglycemia n'ihe banyere ị etụ ọgwụ ethanol, ọgwụ mgbochi mkpali na steroidal na agụụ. N'ihe banyere ethanol, ọ ga-ekwe omume ịzụlite ọrịa disulfiram dịka (mgbu afọ, ọgbụgbọ, ọgbụgbọ, isi ọwụwa).
Ikwesiri imeghari onodu ogwu ahu na oke aru ma obu nke mmetụta uche, na-agbanwe nri. Karịsịa mmetụta nke ọgwụ hypoglycemic bụ ndị agadi, ndị ọrịa na-adịghị enweta nri edozi edozi, ndị ọrịa na-esighi ike, ndị ọrịa na-ata ahụhụ site na enweghi nri. Na nmalite ọgwụgwọ, n'oge nhọrọ nha, ndị ọrịa na-ebute mmepe nke hypoglycemia anaghị atụ aro ka ha na-eme ihe chọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor.

Mpempe mwepụta
Mbadamba 80 mg
Na mbadamba 10 ma ọ bụ 20 na nchịkọta blister.
2, 4, 6 ma ọ bụ 10 blisters maka mbadamba 10 ma ọ bụ 1, 2, 3 blisters maka mbadamba 20 nwere ntuziaka maka iji ya na otu kaadiboodu.

Exbọchị mmebi Afọ 3
Ejila oge emechara ka egosiputara na ngwugwu ahụ.

Ọnọdụ nchekwa
Ndepụta B. N'ebe kpọrọ nkụ, ọchịchịrị na-adịghị elu karịa 25 Celsius. Ekwela ka ụmụaka ghara iru ya.

Usoro ahịa ọgwụ ahịa
Site na ndenye ọgwụ.

Claim emeputa / nzukọ:
Mepee Jolọ Ọrụ Na - Ahịa Kurgan Joint-Stock of Medicines na Synthesis (OJSC Synthesis) 640008, Russia, Kurgan, pr. Constitution, 7