Glurenorm: ntuziaka maka ojiji, nyocha, analogues

Mlọ ọgwụ Glurenorm bụ ọnya hypoglycemic na-elekọta mmadụ, ihe na-amalite na usoro nke ọgbọ nke abụọ. Glurenorm na-akpali secretion nke insulin endogenous site na mkpụrụ ndụ reat-pancreatic, na-eme ka uru glucose dị, na-egbochi usoro nke lipolysis.
Glurenorm na-ebelata insulin na-egbochi imeju na akwara adipose site na ịba ụba ọnụ ọgụgụ ndị na-anabata insulin na usoro ndị na-anabata post-receptor n'ihi ọrụ insulin. Ihe a ga - eme tupu aru aru oru mmanu Glyurenorm bu nnabata insulin.
Mmetụta nke iwetulata ọkwa glucose ọbara dị ala na-amalite nkeji 60-90 mgbe nchịkwa ọnụ wee rute karịa awa 2-3 mgbe nchịkwa.
Ogologo oge nke ike hypoglycemic nke Glurenorm bụ awa 8-10. Ya mere, a na-ahụta Glurenorm dị ka ọgwụ na-eme obere oge.
A na-atụ aro iji sulfonylureas, nke bụ ọgwụ ndị na-eme obere oge maka ịgwọ ndị ọrịa nwere nnukwu ọrịa hypoglycemia, dịka ọmụmaatụ, ndị agadi agadi na ndị ọrịa nwere ọdịda akụrụ.
Ebe ọ bụ na mkpochapu mkpokọ nke Glyurenorm bụ nke a na-eleghara anya, enwere ike ịkọ ọgwụ a tumadi ndị ọrịa nwere ọdịda akụrụngwa ma ọ bụ ọrịa mamịrị nephropathy.
Achọpụtala ịdị mma na nchekwa nke iji Glyurenorm na ndị ọrịa nwere ọrịa mellitus, nke egosiri maka ọgwụgwọ na nkwanye sulfonylurea nke nwere ọrịa imeju na-emetụta.
Mlọ ọgwụ Abalị 2-3 ka abatatịrị 30 mg nke Glurenorm, a ga-enweta mkpo plasma kachasị (500-700 ng / ml), mgbada abụọ gafere na 1 / 2-1 awa. ọgwụ.
Glurenorm na-arụ ọrụ na protein plasma (99%).
Glurenorm bụ metabolized kpamkpam, site na hydroxylation na demethylation. A na-ekepụ ọtụtụ metabolites site na sistemụ biliary na feces. Naanị obere akụkụ nke metabolites dị n’akịrị ya. Naanị 5% nke metabolized dose ka achọpụtara na mmamịrị. Ọbụna mgbe ejirila Glyrenorm ugboro ugboro, mkpịsị akụrụ na-adị obere.
Na mgbakwunye, na nchịkwa oge nile nke Glyrenorm na ndị ọrịa nwere ọrịa mellitus nwere ọdịda akụrụ, enweghị mgbanwe ọ bụla na ụzọ njem ahụ. Onweghi ihe ojoo obula nke ichikota ihe ma obu metabolites ya.
Metabolites ọbara dị ala anaghị arụ ọrụ nke ọgwụ mana anaghị emetụta ọkwa glucose ọbara.
Nnyocha ọgwụ nke emere na oke na ụmụ oke egosila na Glyrenorm na metabolites ya anaghị agabiga BBB ma ọ bụ ihe mgbochi placental.

Ojiji nke ọgwụ Glyurenorm

Usoro ọgwụgwọ izizi
Dịka ọ dị, usoro izizi nke Glenrenorm bụ 1/2 mbadamba (15 mg). A na-ewere ya n'oge nri ụtụtụ. Na enweghi ike, enwere ike ịbawanye dose ahụ. Nyere na enyereghị ihe karịrị mbadamba 2 (60 mg), ịlele Glyurenorm kwa ụbọchị otu ugboro n’oge nri ụtụtụ. Agbanyeghị, mgbe ejiri ya na oke doses, a na-enye njikwa kachasị mma site na ugboro 2-3 kwa ụbọchị. N'okwu a, ekwesịrị ị maximumụ ọnụọgụ kachasị n'oge nri ụtụtụ. A ga-ewere mbadamba mkpụrụ osisi Glenrenorm n'isi mmalite nri. Okwesiri iburu n’uche na ịbawanye ogwu a rue mbadamba 4 (120 mg) kwa ụbọchị anaghị ebute mmụba na-agwọ ọrịa.
Mgbe ị ga-eji usoro ọzọ mee ihe iji dochie onyo hypoglycemic nke ọzọ
A na-ekpebi ọgwụ mgbochi mbụ dabere na ọrịa ahụ n'oge nchịkwa ọgwụ. Mgbe ị na-eji Glurenorm dochie ọgwụ antidiabetic ọzọ, a ga-echetara ya na ihe 1 mbadamba nke Glurenorm bụ ihe ruru 1000 mg nke tolbutamide.
Ngwakọta ọgwụ
Ọ bụrụ na monotherapy na Glurenorm adịghị enye nchịkwa nke glucose ọbara zuru ezu, ekwesịrị ịtụle nha nke biguanide.
Oge ọgwụgwọ ọ dabere na ụdị ọrịa ahụ na arụmọrụ nke ọgwụgwọ.

Ihe mgbochi iji ọgwụ Glurenorm

Typedị insulin na-adabere na ọrịa shuga mellitus, ọrịa shuga na precomatosis, ọrịa shuga na-akpata mgbagwoju anya site na acidosis na ketosis, mgbe atụgharịrị pancreatic, na nnukwu ọrịa nke ọrịa na-efe efe, tupu ịwa ahụ, nnukwu ọrịa akwara, ọnya na-adịghị ala ala (hepatic) porphyria, hyperensitivity to nkwado nke sulfonylurea.

Nsonaazụ nke ọgwụ Glenrenorm

Dịka iwu, ndị ọrịa na-anabata Glurenorm nke ọma, mana n'ọnọdụ ụfọdụ hypoglycemic mmeghachi omume, ọgbụgbọ, ọgbụgbọ, afọ ntachi, afọ ọsịsa, enweghị agụụ, mmeghachi ahụ nfụkasị: itching, eczema, isi ọwụwa, ọgbụgbọ, ọgba aghara nke ebe obibi, thrombocytopenia nwere ike ime.
N'ọnọdụ ụfọdụ, intrahepatic cholestasis, urticaria, Stevens-Johnson syndrome, leukopenia, agranulocytosis nwere ike ịmalite.

Ntụziaka pụrụ iche maka iji ọgwụ Glurenorm

Oge nke ime na lactation. Emebeghị nnyocha banyere ojiji nke Glyurenorm n'oge ime na lactation. Ya mere, ekwesịrị ịhapụ iji Glurenorm eme ihe n'oge a. Ọ bụrụ na etinyere afọ ime, ọ dị mkpa ịkwụsị ịhapụ Glyurenorm ozugbo enwere ike.
N'ịgwọ ọrịa shuga, ịchọrọ nlekọta ahụike mgbe niile dị mkpa. Ekwesịrị ilebara anya n'oge ịhọrọ ọgwụ ma ọ bụ dochie ọgwụ.
Ọ bụ ezie na naanị 5% nke Glurenorm bụ ndị akụrụ wepụrụ ya ma na-anabata ya nke ọma na ndị ọrịa nwere ọrịa akụrụ, a ga-ebu ụzọ nyochaa ndị ọrịa nwere nnukwu akụrụ.
Ndị ọrịa nwere ọrịa shuga na-enwekarị mmepe nke ọrịa obi. Enwere ike belata ihe egwu a naanị site na ịgbasochi anya nri nke dọkịta nyere. Ojiji nke ndị na-a antụ ọgwụ mgbochi agaghị edochi nri ọgwụgwọ nke na-enye gị ohere ịchịkwa oke ahụ onye ọrịa ma bụrụ iwu mmachi n'agbanyeghị iji ọgwụ hypoglycemic. Ndị nnọchi anya ọgwụ na-egbu mmụọ na -eme nri ma ọ bụ nwee mmebi nke usoro usoro onunu ogwu a na-atụ aro nwere ike ibute oke mbelata ọkwa glucose ọbara. Iji shuga, ihe ọetsụetsụ, ma ọ bụ ihe ọ sugụ sugụ na-egbu egbu na-enyekarị aka egbochi ọnọdụ hypoglycemic nke mmalite.
Mmetụta ikike ịkwọ ụgbọ ala ma jiri usoro ndị ọzọ rụọ ọrụ.A ga-adọ ndị ọrịa aka na ntị banyere nnabata nke usoro iji gbochie hypoglycemia mgbe ha na-anya ụgbọala. Nke a dị ezigbo mkpa maka ndị na-enweghị ihe na-arịa hypoglycemia ma ọ bụ chọpụta oge nke hypoglycemia ugboro ugboro. Ekwesịrị ịtụle izi ezi nke ịnya ụgbọ ala n'ọnọdụ ndị a.

Mkparịta ụka ọgwụ ọjọọ Glurenorm

Ekwesiri itinye mmekọrịta na ọgwụ ndị na-emetụta metabolism metabolism.
Ọgwụ ndị nwere ike ịkwalite mmetụta hypoglycemic nke Glurenorm: NSAIDs, MAO inhibitors, oxytetracyclines, ACE inhibitors, clofibrates, cyclophosphamides na usoro ha, sulfonamides na ọgwụ mgbochi ndị ọzọ na-egbochi ịreụ mmanya, ọgwụ antidiabetic ndị ọzọ, insulin.
Ọgwụ ndị nwere ike ịkwalite nsonaazụ hypoglycemic nke Glurenorm: β-adrenergic receptor blockers, ndị ọzọ nwere ọmịiko (dịka ọmụmaatụ clonidine), reserpine, guanethidine. Ihe ndị a nwekwara ike kpuchie ihe mgbaàmà hypoglycemia.
Ọgwụ ndị nwere ike belata mmetụta hypoglycemic nke Glurenorm: GCS, ọgwụ mgbochi steroid, sympathomimetics, homonụ thyroid, glucagon, diuretics (ụdị thiazide ma ọ bụ loop diuretics), diazoxide, phenothiazine, nicotinic acid.
Barbiturates, rifampicin, phenytoin na ihe ndị yiri ya nwere ike belata ogo mmetụta hypoglycemic nke Glyrenorm site na-akpali enzymes imeju.
Mbelata ma ọ bụ mmụba n'ịdị njọ nke mmetụta hypoglycemic nke Glurenorm ka ejiri ya mee ihe na ndị na-emegide H2 na-anabata ndị ọbịa (cimetidine, ranitidine) na mmanya.

Mwepụta wepụtara ya na ihe mejupụtara

Gdị usoro nke Glyurenorm bụ mbadamba mbadamba: gburugburu, dị larịị, na-acha ọcha, nwere beveled n'ọnụ, n'otu akụkụ enwere ihe osise nke ụlọ ọrụ ahụ, n'akụkụ nke ọzọ enwere ihe ize ndụ, n'akụkụ ya abụọ, e nwere ihe osise "57C" (pcs 10 Na blisters, 3, 6 ma ọ bụ 6 Blisita iri na abuo n’otu kaadiboodu).

Ngwakọta ọrụ: glycidone, na mbadamba 1 - 30 mg.

Ihe ndị ọzọ: ahịhịa ọka na -anwụ mmiri, stachi ọka a mịrị amị, magnesium stearate, lactose monohydrate.

Mlọ ọgwụ

Glycvidone na-eme ka njikọ insulin na-arụ ọrụ site na ime ka ụzọ glucose dị n’etiti maka mmepụta nke ihe a. Nnwale anụmanụ na-egosi na ọgwụ na-ebelata insulin na-eguzogide na anụ ahụ adipose na anụ ahụ imeju site na ịbawanye mmekọrịta nke ndị na-anabata insulin, yana ịme ume na post-receptor sistem nke insulin kpatara. Mmetụta hypoglycemic na-amalite 1-1.5 awa mgbe nchịkwa ọnụ. Edere nsonaazụ kachasị elekere ruo awa 2-3 mgbe nchịkwa gachara were awa 8-10. Glycvidone bụ ihe dị mkpụmkpụ nke na-eme ihe na - eme ka ndị ọrịa nwere ụdị ọrịa shuga abụọ nke nwere nnukwu ọrịa hypoglycemia, dịka ọmụmaatụ, na ndị ọrịa agadi ma ọ bụ ndị nwere ọrịa ezumike.

Ebe ọ bụ na glycidone na-ewepụta akụrụ ya n’obere obere, enwere ike ị drugụ ọgwụ ahụ maka ndị ọrịa nwere ọrịa mamịrị nephropathy na arụ ọrụ ezumike n’akuku. Enwere ihe akaebe na iwere Glenrenorm na ndị ọrịa nwere ụdị ọrịa shuga 2 nke na-arịa ọrịa shuga, na-aba oke ma dịkwa mma. Agbanyeghị, mwepụ nke ihe na - arụ ọrụ n'ime ndị ọrịa dị ntakịrị gbochiri egbochi. N'okwu a, a na-atụ aro ịhọpụta glycidone n'ime ndị ọrịa nwere ọrịa mellitus nke nnukwu ịba ọcha n'anya.

Nsonaazụ nke ọmụmụ ụlọ ọgwụ gosipụtara na ojiji nke Glyurenorm maka ọnwa 18 na ọnwa 30 anaghị akpata mmụba n’arụ ahụ, na n'ọnọdụ ụfọdụ, ọbụladị mgbadata ogo ahụ site na 1-2 n'arọ. Ọmụmụ ihe atụ na-amụ nke ejiri mụọ ụdị sulfonylurea ndị ọzọ gosipụtara enweghị mgbanwe dị ukwuu na oke ahụ mmadụ na ndị ọrịa na-ewere glycidone.

Mlọ ọgwụ

Na otu ingestion nke glycidone na dose nke 15 ma ọ bụ 30 mg, a na-enweta ihe ahụ site na ngwa ngwa nri na oke ọsọ na ihe niile kpamkpam (80-95%). Ntinye uche kachasị na plasma ọbara 0,55 μg / ml (dịgasị iche site na 0.12 ruo 2.14 μg / ml) ma erute ihe dị ka elekere 2 na nkeji iri na ise (mmụba na oke nke 1.25-4.75 ga-ekwe omume awa). Mpaghara dị n'okpuru usoro nlebara oge (AUC) bụ 5.1 μg × h / ml (mgbanwe n'etiti 1.5 na 10.1 μg × h / ml kwere omume).

Onweghi ihe di iche na uzo ogwu pharmacookinetic n’etiti ndi mmadu nwere ahuike na ndi oria obi uto.

Ejiri Glycvidone mara oke mmekọrịta ya na protin plasma kariri 99%. Ihe omuma banyere uzo banyere ihe ma obu ihe ndi n’emeghari ahu site n’uju obara na ihe mgbochi. Achọpụtabeghị ihe gosiri na glycidone nwere ike ịdị na mmiri ara.

Glycvidone bụ metabolized kpamkpam na imeju, ọkachasị site na demethylation na hydroxylation. Glycvidone metabolites anaghị arụ ọrụ ọgwụ ma ọ bụ gosi ọrụ dị ntakịrị ma e jiri ya tụnyere onyinye nne na nna.

Glycvidone metabolites na-adịkarịkarị site na feces, ma ọ bụ naanị obere obere n'ime ha ka amịrị na mmamịrị. Nchoputa nyocha gosiri na mgbe nchịkwa ọnụ gasịrị, ihe dị ka 86% nke glycidone na-apụtakarị na eriri afọ. Odika 5% (n'ụdị metabolites) nke ọgwụ a na-eme ka a na-ahụrịrị site na akụrụ, na usoro a abụghị nke a na-a doseụ ma ọ dabaghị na ụzọ nchịkwa nke Glyrenorm. N'agbanyeghị na ị na-eji ọgwụ ahụ mgbe niile, ọ na-adị na mmamịrị na-adịkarị ala.

Oge iwepụ ọkara ndụ bụ awa 1.2 (ọnụọgụ nke mgbanwe bụ awa 0.4-3), ọkara njedebe ikpochapụ bụ ihe dịka elekere asatọ (uru ahụ nwere ike ịdị iche site na awa 5.7 ruo awa 9.4).

N'ime ndị ọrịa dị afọ iri na ụma dị elu, usoro ọgwụ ọgwụ yiri ibe ha. N'ime ndị ọrịa nwere akụrụngwa akwara na hepatic, oke nke glycvidone na-apụ apụ na feces. Enwere ihe akaebe na metabolism nke akụkụ ahụike na-arụ ọrụ na-anọgide na-agbanwebeghị na ndị ọrịa nwere ọrịa imeju. Ebe ọ bụ na a na-ewepụta glycidone site na akụrụ ya na obere obere, enweghị nchịkọta nke ọgwụ ahụ na ndị ọrịa nwere dysfunction akụrụ.

Ntuziaka maka iji Glyurenorm: usoro na usoro onunu ogwu

A na-ewere ọnụ glyrenorm ọnụ dị ka dọkịta si kwuo banyere ọgwụ na nri.

Na mmalite ọgwụgwọ, dịka iwu, a na-enye ½ mbadamba ụrọ n'oge nri ụtụtụ (n'isi mmalite nri). Ọ bụrụ n ’enweghị nkwalite, ọ na-eji nwayọ nwayọ elu ya.

Ọ bụrụ na ubochi ụbọchị anaghị agafe mbadamba abụọ, a ga-a inụ ya na 1 ụtụtụ. Ọ bụrụ na ọ karịrị, ọ dị mkpa iji nkewa abụọ mee ya, ma were akụkụ kacha ukwuu n'ụtụtụ mgbe nri ụtụtụ.

Oke kacha anabata kwa ụbọchị bụ 4 mbadamba. Thebawanye usoro nke ihe karịrị mbadamba 4 bụ ihe arụ ọrụ, ebe ọ bụ na ọ dịghị ebute mmụba arụmọrụ.

Apụla nri mgbe ị takingụchara Glyurenorm ma kwụsị ị theụ ọgwụ ahụ na ịgaghị dọkịta.

Mgbe ị na-ede ọgwụ ahụ na ọgwụ karịrị 75 mg (mbadamba 2.5), ndị ọrịa nwere ọrụ imeju na-arụ ọrụ chọrọ nlezianya nyochaa ọnọdụ ahụ.

N'ihe banyere mmetụta ọgwụgwọ na-ezighi ezu n'oge monotherapy na Glyrenorm, enwere ike ịkọ ọgwụ ọgwụgwọ na njikọta na metformin.

Nsonaazụ

• Usoro nke Hematopoietic: leukopenia, thrombocytopenia, agranulocytosis,
• Usoro ụjọ: ihi ụra, vertigo, paresthesia, isi ọwụwa, inwe ahụ ike gwụ,
• Usoro obi: extrasystole, hypotension, angina pectoris, akwara obi,
• Usoro nri: ọgbụgbọ, agụụ na-agụ gị, akpịrị na-akpọ nkụ, ahụ erughị ala afọ, afọ ntachi / afọ ọsịsa, vomiting, cholestasis,
• Metabolism: hypoglycemia,
• Ahụ nke ọhụhụ: ọgba aghara,
• Akpụkpọ anụ na ọnya dị n'okpuru ala: mmeghachi omume na-ahụ maka ọrịa, urticaria, ihe ngbu, itching, Stevens-Johnson syndrome,
• Ndị ọzọ: obi mgbu.

Dodoụbiga ya ókè

Lynwebiga ókè nke Glyurenorm nwere ike ịkpalite hypoglycemia, nke ihe mgbaàmà ndị a na-ekpebisi ike: nchekasị moto, tachycardia, palpitations, okwu isi na ọhụụ, ọsụsọ, agụụ, oke iwe, ehighị ụra, isi ọwụwa, ịma jijiji, na nkụda mmụọ. Mgbe ihe ịrịba ama nke hypoglycemia pụtara, ọ dị mkpa iji nri bara ụba na carbohydrates ma ọ bụ glucose (dextrose).Ọ bụrụ na ọrịa hypoglycemia dị ukwuu, ya na ọnwụ nke mmụọ ma ọ bụ enweghị onwe ya, a na-edozi dextrose n'ọbara. Mgbe onye ọrịa nwetasịrị onwe ya, ọ kwesịrị iwere carbohydrates na-agbari ngwa ngwa iji zere mwakpo hypoglycemic ugboro ugboro.

Ime na lactation

Ihe omuma banyere ojiji nke glycidone na ndi oria n’oge di ime na ebe a na-ara aru adighi. Womenmụ nwanyị dị ime chọpụtara ọrịa shuga chọrọ nlekọta nke plasma glucose mgbe niile. O Tara ọgwụ hypoglycemic ọgwụ na ndị ọrịa n'oge afọ ime anaghị ekwe nkwa njikwa glycemic dị mkpa. Maka nke a, iwere Glyurenorm n'oge afọ ime.

Ọ bụrụ na onye ọrịa ahụ tụụrụ ime n’oge ị withụ ọgwụ ahụ, ma ọ bụ na-eme atụmatụ ya, glycidone ga-akagbu ma gbanye ya insulin.

Na arụ ọrụ imeju

A naghị akwado glurenorm maka ndị ọrịa nwere dysfunctions umeji dị ukwuu, ebe ọ bụ 95% nke ọgwụ a isụrụ bụ metabolized na imeju ma na-apịpụta ya na feces. Ọmụmụ nyocha nke ndị ọrịa nwere ọrịa mellitus na dysfunctions nke nsogbu dị iche iche (gụnyere nnukwu ọrịa imeju, tinyere ọbara mgbali) butere, gosipụtara na glycvidone emeghị ka njọ na-arụ ọrụ nke imeju, mmụba nke omume nke mmetụta, na mmeghachi omume hypoglycemic. abiaghi.

Mkparịta ụka ọgwụ ọjọọ

Ọ ga - ekwe omume ịkwalite mmetụta hypoglycemic nke Glurenorm na nchịkwa nke oge a ọgwụ ndị na - esote: ọgwụ monoamine oxidase inhibitors, ọgwụ mgbochi na - abụghị steroidal, analgesics, ndị na - ezigara ọgwụ mgbochi, tricyclic antidepressants, tetracyclines, insulin, ọgwụ ndị ọzọ na-akpata hypeglycemic cylọg enzyme , sulfonamides, sulfinpyrazone, clofibrate, clarithromycin, chloramphenicol, allopurinol.

Sympatholytics (gụnyere clonidine), beta-mgbochi, guanethidine na reserpine enweghị ike ịkwalite mmetụta hypoglycemic nke Glyrenorm, mana n'otu oge ahụ na-ekpuchi ihe mgbaàmà hypoglycemia.

Ọ ga-ekwe omume ibelata mmetụta hypoglycemic nke Glyurenorm mgbe ị na-edepụta ọgwụ ndị na-esonụ: sympathomimetics, glucocorticosteroids, homonụ thyroid, thiazide na loop diuretics, mgbochi mkpịsị edemede, nkwadebe nicotinic acid, aminoglutetimide, phenothiazine, diazoxide, glucagon, rifen.

N'iji oge ethanol eme ihe, histamine H blockers₂-receptors (dịka ọmụmaatụ, ranitidine, cimetidine), ọ ga - ekwe omume ma ịkwalite ma wedata ike hypoglycemic nke Glyurenorm.

Ihe analogues anaakpo glurenorm bu: Amix, Glair, Glianov, Glibetic, Gliklada.

Ngwakọta na ụdị ntọhapụ

Glurenorm dị n'ụdị mbadamba nkume, na-acha ọcha gburugburu na akara nke "57C" na akara ụlọ ọrụ na azụ. Mbadamba ụrọ nke ọ bụla nwere 30 mg nke ihe na - arụ ọrụ - glycidone, a na - ewepụta ihe inyeaka n'ụdị: lactose monohydrate, stachi ọka, na - akpọnwụ akpọnwụ, magnesium stearate. Mbadamba ụrọ n’agba iberibe iri. na blisters juru n'ọnụ na kaadiboodu nke 3, 6 ma ọ bụ 12 PC.

Usoro onunu ogwu na nhazi

Ana-eji mbadamba nkume ndị ahụ. Usoro a ga-ewere Glenrenorm na usoro ị theụ ọgwụ ahụ na-adabere na ndabere nke metabolism metabolism.

N’ezie, ọgwụ mbụ bụ ọkara mbadamba, a na-atụ aro ị itụ ya n’oge nri ụtụtụ. Ọzọkwa, ọ bụrụ na ọ dị mkpa, a na-eji nwayọọ nwayọọ na-abawanye ọgwụ (dịka ndụmọdụ ndị dọkịta si dị).

N'ọnọdụ ebe edere onye ọrịa ahụ mbadamba mbadamba abụọ kwa ụbọchị, enwere ike iwere ya otu ịga. Usoro ogwu Glenrenorm dị elu kwesiri ikewa abụọ ma ọ bụ atọ.

Usoro na ọnọdụ nchekwa

N'ikwekọ na ntuziaka ahụ, ekwesịrị ịchekwa Glurenorm n'ebe gbara ọchịchịrị, kpọọ nkụ ma ebe ụmụaka agaghị eru, na-ekpo ọkụ n'ime ụlọ.

Site na ụlọ ahịa ọgwụ, ọgwụ na-enye ọgwụ ọgwụ. Ndụ nchekwa nke mbadamba nkume ahụ, dabere na ndụmọdụ ndị emepụtara, bụ afọ ise. Enweghị ike iji glurenorm mee ihe mgbe ọ gwụsịrị.

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Omume ọgwụ

Glurenorm na-akpata mmetụta nke pancreatic na extrapancreatic, na-enyere aka na-akpali ihe nzuzo nke insulin endogenous (nhazi ihe kachasị mkpa nke carbohydrate metabolism) site na mkpụrụ ndụ beta nke pancreatic, ebe na-akwalitekwa ọrụ nke insulin, na-emetụta oke mmịpụta nke akwara na umeji, na-egbochi lipolysis na adipose anụ ahụ. Ntinye uche nke glucose n’ime ọbara na-amalite ibelata otu awa mgbe ị theụsịrị ọgwụ, mmetụta kachasị na-enweta mgbe awa 2-3 gachara, oge nke ihe Glenrenorm dịka nyocha dị na awa 8-10. Glurenorm na-abanye kpamkpam na ngari nri, metabolized na imeju na-ewepụtakarị site na eriri afọ naanị 5% na mmamịrị.

Glurenorm, ịbụ ihe na - eme ka sulfonylurea, bụ ọgwụ dị mkpụmkpụ, ya mere a na - atụ aro ka ndị ọrịa na - arịa ọrịa shuga 2dị nke 2 nwere nnukwu ọrịa hypoglycemia (afọ toro ogologo ma ọ bụ na - arụ ọrụ ezumike na - arụ ọrụ). Ọzọkwa, enwere ike iji ọgwụ ahụ mee ihe na ndị ọrịa nwere ọrịa nephropathy na-arịa ọrịa mamịrị na ọdịda akwara, ebe ọ bụ na akụrụ na-ewepụta glycidone na obere ego.

Glenrenorm Contraindications

Dabere na ntuziaka ndị agbakwunyere na Glurenorm, a na-egbochi ọgwụ a na:

• Nnukwu imeju,
• Ọrịa shuga 1dị 1
• Ọrịa mamịrị na ọrịa precomatous,
• Na-ekwupụta ụdị mmerụ ahụ
• Ọrịa na-efe efe
• Ime na oge inye ara,
• A na - ahụkarị ọgwụ insulin,
• Galactosemia, ụkọ lactase,
• N'agbata afọ 18,
• Ejiri ọgwụ mgbochi.

Ọzọkwa, na-akpachapụ anya, a na-enye ọgwụ ahụ ka ndị ọrịa nwere ọrụ ọrịre thyroid, na-arịa ọrịa febrile, ma na-arịa ọrịa ị alcoụbiga mmanya ókè.

Nhazi nke ọgwụ, nkọwa ya, nkwakọ ngwaahịa, ụdị

N’ụdị dị a doaa ka nkwadebe Glurenorm na-arụpụta? Ntụziaka maka iji mee ka a mara na ngwaahịa a dị n'ụdị nke mbadamba ọcha na nke dị larịị nke okirikiri, ya na ntanetị ọnụ na beveled, yana ihe osise "57C" na akara ụlọ ọrụ ahụ.

Akụkụ bụ isi nke ọgwụ a na-enyocha bụ glycidone. Ọ na-agụnye stachi ọka a mịrị amị, lactose monohydrate, ọka ọka soluble na magnesium stearate (nchịkọta ndị ọzọ).

Ọgwụ Glurenorm (mbadamba) na-ere na blisters nke iberibe 10, nke a na-akwakọba na ngwugwu kaadiboodu.

Omume ọgwụ

Gini bu ogwu Glurenorm? Ntụziaka maka iji mee ihe na-akọ na nke a bụ ihe nnọchianya hypoglycemic, usoro nke sulfonylurea (ọgbọ nke abụọ). Ezubere ya maka nchịkwa ọnụ.

Ọgwụ a na-a hasụ na-enwe extrapancreatic na pancreatic utịp. Ọ na-akpali nzuzo nke insulin ma na-eme ka ụzọ glucose dị n’etiti ụzọ o siruru guzobe sie ike.

Nlele na anụmanụ anụmanụ n'ụlọ nyocha gosipụtara na ọgwụ "Glyurenorm", nkuzi nke dị na igbe kaadiboodu, nwere ike belata nguzogide insulin na anụ ahụ adipose na imeju onye ọrịa. Nke a na - eme site na mkpali nke usoro postreceptor, nke insulin na-agbagha, yana mmụba nke ndị na - anabata ya.

Mmetụta hypoglycemic mgbe ị takingụ ọgwụ ahụ na-etolite mgbe minit 65-95 gasịrị. Maka mmetụta kachasị ukwuu nke ọgwụ ahụ, ọ na - apụta mgbe ihe dị ka awa 2-3 na - adịgide ihe dị ka awa 8-10.

Ngwongwo kinetic

Ntuziaka maka iji "Glyurenorm" na-ekwu na iji otu ọgwụ a (15-30 mg) na-enye aka na ngwa ngwa ya na iweze zuru ezu site na eriri afọ (ihe dị ka 80-95%). O ruru oke nke ntinye uche ya mgbe awa abụọ gachara.

Ihe na-arụ ọrụ nke ọgwụ ahụ nwere ezigbo mmekọrịta maka protein protein.

Enweghị data dị na uzo glycidon ma ọ bụ usoro ya site na placenta ma ọ bụ BBB. Enweghi ihe omuma banyere uzo nke glycidone banye n’ime mmiri ara.

Ebee ka metabolism nke ọgwụ "Glyurenorm" dị? Ntụziaka maka ojiji na-ekwupụta ọgwụ a na-agbagha n'ime imeju site na demethylation na hydroxylation.

Otutu nke glycidone sitere na choputara n’eriri. Ndụ ọkara nke ọgwụ a bụ 1-2 awa.

N’ime ndị ọrịa agadi na nke afọ, usoro ihe ọmụmụ nke Glyurenorm bụ otu.

Dabere na ndị ọkachamara, metabolism nke ọgwụ a adịghị agbanwe agbanwe na ndị ọrịa nwere ọrịa imeju. Okwesiri iburu n’uche na n’ebe ndi oria na- aru ​​oru oma n’igha nkpuru obi, ogwu a adighi achikota.

N’okpuru ọnọdụ dị ka ọgwụ “Glurenorm” kasị dị irè? Ntụziaka maka ojiji, nyocha na-atụ aro na ngosipụta maka ojiji a bụ ụdị ọrịa shuga mkpụrụ ọrịa shuga 2 n'ime ndị agadi na ndị agadi (na enweghị usoro ọgwụgwọ nri).

Amachibidoro ị takingụ ọgwụ

N'ọnọdụ dị a isaa ka a machibidoro ịdebe mbadamba ọgwụ Glurenorm? Ntụziaka maka ojiji a na-egosi contraindications ndị a maka ọgwụ a:

• oke okike
• Ọrịa shuga 1dị 1
• oke umeji akwara,
• mamịrị acidosis, precoma, ketoacidosis na coma,
• oge mgbe njikọta nke pancreas,
• Ọrịa na-adịghị ahụkebe dịka ụyọkọ galactosemia, ekweghị ibelata lactose, enweghị lactase na glucose-galactose malabsorption,
• ọnọdụ ọjọọ nke onye ọrịa (dịka ọmụmaatụ, nnukwu ịwa ahụ, ọrịa na-efe efe),
• oge ime
• obere afọ (n'ihi ezughi oke data na nchekwa yana ịgwọ ọgwụ n'oge otu a),
• oge ara
• hypersensitivity na sulfonamides.

Ọgwụ "Glurenorm": ntuziaka maka ojiji

A na-enye mbadamba glurenorm naanị n'ime. Mgbe ị na-a themụ ha, ị ga-agbaso ndụmọdụ dọkịta ahụ nyere gbasara etu usoro ọgwụ si a andụ na nri. Amachibidoro ịhapụ ị theụ ọgwụ ahụ n’ebughị ụzọ kpọtụrụ onye ọkachamara.

Usoro mbụ nke ọgwụ a na-ekwu bụ mbadamba 0,5 (dịka 15 mg) n'oge nri ụtụtụ mbụ. Ekwesịrị ị Theụ ọgwụ a na mmalite nri. Amachibidoro ya, ịhapụ iri nri.

Ọ bụrụ na iji 1/2 tebụl emeghị ka ọ dịkwuo mma, mgbe ahụ, mgbe ị nyochachara dọkịta, a na-eji nwayọọ nwayọọ belata usoro onunu ogwu. Site na iji ọgwụ kwa ụbọchị nke "Glyurenorm" enweghị mbadamba 2, enwere ike iwere ya otu ugboro n'oge nri ụtụtụ.

Ọ bụrụ na dọkịta enyere iwu ị higherụ ọgwụ dị elu karịa, mgbe ahụ maka nsonaazụ kachasị mma, ha ga-ekewa abụọ ma ọ bụ atọ.

Asingbawanye usoro nke ihe karịrị mbadamba 4 kwa ụbọchị anaghị eme ka ọ dịkwuo irè. Ya mere, ị takingụ ọgwụ "Glyurenorm" karịa ngafe egoro ka akwadoro.

N'ime ndị nwere nsogbu ọrụ ezumike nká, ọchọghị usoro iji usoro onunu ogwu eme ihe.

Iwere ọgwụ a karịrị 75 mg na ndị ọrịa nwere ọrụ imeju na-achọ dọkịta mgbe niile.

N'ọnọdụ ezughi oke ọgwụgwọ, ya na "Glurenorm" nwere ike inye onye ọrịa ọgwụgwọ ọzọ "Metformin".

Casesụbiga okwu ókè

Iwere ihe dị iche iche nke usoro sulfonylurea na-edugakarị hypoglycemia. Na mgbakwunye, ịdoụ ọgwụ ọ canụdoụ gabigara ókè nwere ike ibute ọrịa ndị a: ọsụsọ, tachycardia, ahụ erughị ala, agụụ, isi ọwụwa, nkwarụ, ịma jijiji, ehighị ụra nke ukwuu, ụjọ moto, ọhụhụ na ọhụụ.

Mgbe ihe ịrịba ama nke hypoglycemia pụtara, ị ga-ewere glucose ma ọ bụ nri nwere carbohydrates.

Nsonaazụ

Ugbu a ịmara ihe kpatara eji ede ọgwụ dịka Glurenorm. Ntụziaka maka ị usingụ ọgwụ a.

Dabere na ndị ọrịa, mgbe ị na-a thisụ ọgwụ a, ị nwere ike inweta:

• thrombocytopenia, angina pectoris, agranulocytosis,
• paresthesia, hypoglycemia, dizzness,
• leukopenia, isi ọwụwa, extrasystole, iro ụra,
• ebe obibi, ọgba aghara, ike ọgwụgwụ,
• ọrịa obi, akwara nkụ, ọrịa Stevens-Johnson,
• agụụ belata, mmeghachi omume nsị, eserese, ihe ngbu,
• urticaria, vomiting, mgbu obi, cholestasis,
• afọ ntachi, itching nke anụ ahụ, afọ ọsịsa, ahụ erughị ala na afọ.

Njikọ Ọgwụ

Site na nhazi glycidone na Allopurinol, AC inhibitors, antifungal ọgwụ, analgesics, coumarineri, NSAIDs na ndị ọzọ, enwere ike ịbawanye ike hypoglycemic nke mbụ.

Rifampicin, barbiturates, yana Phenytoin belata mmetụta hypoglycemic nke Glyurenorm.

Ndụmọdụ pụrụ iche

Ndị na-ahụ maka hypoglycemic maka nchịkwa ọnụ ekwesịghị dochie nri ọgwụgwọ.

Ndị nwere ọrịa shuga kwesịrị iso ndụmọdụ niile nke dọkịta.

Mgbe ihe ịrịba ama nke hypoglycemia pụtara, ị kwesịrị ị takeụ nri nwere shuga ozugbo.

Imega ahụ nwere ike ịkwalite mmetụta hypoglycemic nke ọgwụ.

N'ihi eziokwu ahụ na akụrụ nke glycidone site na akụrụ bụ ihe na-enweghị isi, enwere ike ịde ọgwụ a na-atụle n'enweghị nsogbu ọ bụla maka ndị ọrịa nwere nsogbu akụrụ, yana nephropathy mamịrị.

N'ime usoro ọmụmụ nke ụlọ ọgwụ, achọpụtara na ojiji ọgwụ a na-ajụ ajụjụ maka ọnwa iri atọ enyeghị aka na mmụba na ịdị arọ nke ndị ọrịa. Ọzọkwa, enwere ikpe ọnwụ site 1-2 n'arọ.

Analogs na nyocha

A na-ezo aka ọgwụ ndị a na-ezo aka na analogues Glurenorm: Gliklada, Amiks, Glianov, Glayri, Glibetik.

Nyocha banyere ọgwụ na ajụjụ a nwere ike ịchọta dị iche iche. Dabere na akụkọ banyere ndị ahịa, ọgwụ a dị oke mma ma nweta onye ọ bụla. Agbanyeghị, ekwesịrị iburu n'uche na ọtụtụ ndị ọrịa na-echegbu onwe ha maka ndepụta mmeghachi omume ọjọọ nke usoro a. Ọ bụ ezie na ndị dọkịta na-ekwu na ha dị ụkọ ma bụrụ naanị n'ọnọdụ ụfọdụ.