Serotonin na norepinephrine reuptake inhibitor. Ọ dị ntakịrị na-egbochi iwepu dopamine, enweghị mmekọrịta dị mkpa maka histamine na dopamine, cholinergic na ndị na-anabata adrenergic. Usoro nke ọgwụgwọ ọgwụgwọ duloxetine na nkụda mmụọ bụ n'ihi mgbochi nke reuptake nke serotonin na norepinephrine na, n'ihi nke a, ịba ụba serotonergic na noradrenergic neurotransmission na Central ụjọ usoro. Duloxetine na-edozikwa ọnụma mgbu ahụ n'ụdị nnwale ụfọdụ nke neuropathic na mgbu mgbu ma belata ogo mgbu na usoro mgbu mgbu na-adịghị ala ala. Mmetụta analgesic duloxetine nwere ike ịbụ n'ihi nwayọ na mbufe nke ntụgharị nociceptive na sistemụ akwara.
A na-etinye Duloxetine nke ọma mgbe nchịkwa ọnụ gasịrị. Nleta kachasị na plasma ọbara ruru elekere isii mgbe nchịkwa gasịrị. N’otu oge oriri a na-eji nwayọọ kwụsịlata mmịpụta, oge a na-etinye obubu n’obara ọbara na-abawanye site na awa isii ruo awa iri, ebe a na-agbada ma belata (ihe dịka 11%).
Duloxetine nwere ihe jikọrọ ya na protein ndị dị na plasma (karịa 90%).
Duloxetine bụ metabolized nke ukwuu na ahụ, metabolites na-abụkarị nke mmamịrị. The isoenzymes CYP 2D6 na CYP 1A2 na-eme ka e guzobe nnukwu metabolites abụọ nke duloxetine (glucuronide na 4-hydroxyduloxetine, sulfate jikọtara ya na 5-hydroxy, methoxy-duloxetine). Metabolites ndị a rụpụtara anaghị arụ ọrụ ọgwụ.
Ndụ ọkara nke duloxetine bụ awa 12. Ọkara zuru oke nke duloxetine si plasma ọbara bụ 101 l / h.
N'ime ndị ọrịa nwere nsogbu akụrụngwa njedebe, ndị na-adịkarị na usoro akwara, a na-abawanye okpukpu abụọ na mkpokọta duloxetine na plasma ọbara na mmụba na AUC ma e jiri ya tụnyere ndị mmadụ nwere ahụ ike. Ya mere, n'ime ndị ọrịa nwere akwara gbasara akwara na-adịghị ala ala, a na-edenye duloxetine na ntakịrị mmalite.

Ojiji ọgwụ Duloxetine

Maka nkụda mmụọ na neuropathy na-arịa ọrịa shuga, a na-enye ya ọnụ site na iji 60 mg otu ugboro kwa ụbọchị, n'agbanyeghị nri oriri. N'ime ụfọdụ ndị ọrịa, enwere ike ịkwado otu ọgwụ dị elu (ruo ogo nke -120 mg / ụbọchị na usoro abụọ kewara). Emebeghị ịmụ banyere nchịkwa na usoro onunu ogwu karịrị 120 mg / ụbọchị.
Usoro ọgwụgwọ maka ndị ọrịa na ọkwa nke ikpeazụ nke ọdịda akwara (mwepụ nke creat30 ml / minin) bụ 30 mg 1 oge kwa ụbọchị.
A na-enye ndị ọrịa nwere ọrịa cirrhosis obere oge mbido ma ọ bụ ogologo oge n'etiti usoro onyonyo.
Onweghi mgbanwe ndozi nke duloxetine n'ime ndị agadi ma ọ bụ ndị ọrịa toro eto. N'ime ndị ọrịa na-erubeghị afọ 18, a mụọbeghị mmetụta nke duloxetine.

Nsonaazụ Duloxetine

N'ime ule ụlọọgwụ, a chọpụtara ihe na - akpata ihe ọjọọ dịka afọ ntachi, ọgbụgbọ, ọnụ akọrọ, nkụda mmụọ, ike ọgwụgwụ, nsogbu ehighị ụra na isi ọwụwa (≥10%). Obere oge (na nke commonly10%, mana ≥1%) - tachycardia, dyspepsia, vomiting, agụụ, nri ura, ịma jijiji, iju mmiri, ịcha mmiri, inwe mmetụta dị ọkụ, mkpọtụ. N’akụkụ nke usoro ịmụ nwa, ejisịkọ ahụ na-agwụ ya (ọnụọgụ sọ a10%, mana ≥1%), mbelata libido na anorgasmia. N’oge na-adịghị anya (≤1%, mana ≥0.1%) - eriri afọ, stomatitis, ọbara mgbali elu, oke ibu, mgbatị akwara, uto na nkwarụ ọhụụ, mgbakasị ahụ, njigide urinary.
Withgwọ ọrịa duloxetine na ọnwụnwa ụlọ ọgwụ na-achịkwa nwere ntakịrị mmụba ma e jiri ya tụnyere placebo na ọkwa nke AlAT, AsAT na KFK.
N’oge ọnwụnwa nke duloxetine maka ọgwụgwọ nke ọrịa obi na-arịa ọrịa shuga, nkezi afọ nke ọrịa shuga bụ ihe dị ka afọ iri na otu, ngụkọta oge mbụ nke glucose na-ebu ọnụ bụ ihe ruru 163 mg / dl, na ngụkọta oge mbụ nke glycosylated haemoglobin bụ 7.80%. N'ime ọmụmụ ihe ndị a, enwere ntakịrị mmụba na mbido ọbara glucose mbụ na-ebu ọnụ mgbe izu iri na abụọ gasịrị na ndị ọrịa na-ewere duloxetine ma e jiri ya tụnyere placebo, n'oge usoro maka izu 52. Enweghị mgbanwe na haemoglobin glycosylated, body body pressure, lipid concentration (cholesterol, LDL, HDL, TG) ma ọ bụ mmetụta ọ bụla metụtara ọrịa shuga.
Dika ihe omumu ahia mgbe edechara, ihe ndia ka ama ama:
na akụkụ ahụ nke ọhụụ: dịkarịsịrị ala (≤0.01%) - glaucoma,
site na sistemu nke hepatobiliary: dịkarịsịrị ala (≤0.01%) - ịba ọcha n'anya, jaundice,
si dịghịzi usoro: dịkarịsịrị ala (≤0.01%) - mmeghachi omume anaphylactic,
sitere na nyocha ụlọ nyocha: dịkarịsịrị ala (≤0.01%) - ụba ọrụ nke AlAT, AcAT, alkaline phosphatase, ọkwa bilirubin ọbara,
site n'akụkụ nke metabolism: dịkarịsịrị ala (≤0.01%) - hyponatremia,
n'akụkụ anụ ahụ: adịkarịghị (0.01-0.1%) - ihe ọkụ ọkụ, ọ na-adịkarịkarị (≤0.01%) - ọrịa angioedema, Stevens-Johnson syndrome, urticaria,
site na obi: dịkarịsịrị ala (≤0.01%) - orthostatic hypotension na syncope (ọkachasị na mmalite ọgwụgwọ).

Ntụziaka pụrụ iche maka iji ọgwụ Duloxetine

A ga-enyocha ndị ọrịa nwere nnukwu igbu onwe ha n'oge ọgwụgwọ, ebe ọ bụ na tupu mmalite mgbaghara dị ukwuu, anaghị ewepụ ohere nke igbu onwe ya.
Agụbeghị ọgwụ duloxetine na ndị ọrịa na-erubeghị afọ 18, ya mere, ekwesighi inye ya ndị otu ọgbọ a.
Dị ka ọ dị n'iji ọgwụ ndị ọzọ na-eme ihe na sistemụ akwara, na ndị ọrịa nwere ọrịa manic, akụkọ ihe mere eme nke ọdịdọ, a ga-eji nlezianya duloxetine mee ihe.
Enweela akụkọ banyere ọdịdị mydriasis na njikọ nke duloxetine, yabụ, iji duloxetine na ndị ọrịa nwere mgbali intraocular dị elu ma ọ bụ n'ihe banyere ihe ize ndụ nke ịmalite glaucoma dị warara nnukwu akụkụ kwesịrị iji ya kpachara anya.
A kọrọ na mmụba nke mkpokọta duloxetine na plasma ọbara na ndị ọrịa nwere nnukwu akụrụngwa ọdịda (creatinine mwepu ml30 ml / min) ma ọ bụ ọrịa imeju siri ike. A gwara ndị ọrịa dị otú ahụ ka ha kọwaa duloxetine na obere mbido mbụ.
N'ebe ụfọdụ ndị ọrịa nọ, ị duụ duloxetine na-eduga n'ịbawanye ọbara mgbali. N'ime ndị ọrịa nwere ọbara mgbali elu (ọbara mgbali akwara) na / ma ọ bụ ọrịa ndị ọzọ nke usoro obi, a na-atụ aro ka ọ nyochaa ọbara mgbali.
Na omumu ihe omumu, ihe mmuta di n’ọrụ nke enzymes nke obara dibara. N'ime ọtụtụ ndị ọrịa na-anata duloxetine, mmụba a dị obere oge wee kwụsị mgbe ịkwụsịsịrị duloxetine. Nnukwu mmụba na ọrụ nke enzymes imeju (ihe karịrị ugboro iri karịa nke nkịtị) ma ọ bụ mmebi imeju na cholestasis, ma ọ bụ mmụba dị ukwuu na ọrụ enzyme yana mmebi imeju adịkarịghị njọ, n'ọnọdụ ụfọdụ, ọ bụ ihe metụtara ị wasụbiga mmanya ókè.
Duloxetine enweghi mmetụta mutagenic na nnwale in vitro na na vivo.
Emebeghi ihe omumu ihe nlere anya nke oma nke oma banyere ihe duloxetine di n’ime nwanyi di ime, ya mere adighi akwado ka eji ya n’oge odi ime.
Duloxetine na-apụ apụ na mmiri ara. Odika odika odibo nwata obula bu 0.14% nke onodu diri nwanyi n’agba ara (mg / kg). Emebeghi nchekwa nke duloxetine na ụmụ aka, yabụ na akwadoghị inye nwa ara ka ị na-ewere duloxetine.
N'oge ọgwụgwọ duloxetine, ndị ọrịa kwesịrị izere omume ndị dị ize ndụ nke chọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor.

Mkparịta ụka ọgwụ ọjọọ Duloxetine

Ekwesighi iji ọgwụ DOxetine de otu oge ka ọ bụrụ ndị na - egbochi MAO ma ọ bụ na ọ dịkarịa ala ụbọchị 14 ka ịkwụsịsịrị ọgwụgwọ na ndị na - egbochi MAO. Nyere ọkara nke duloxetine, ekwesighi ekwenye ndị na - egbochi MAO ma ọ dịkarịa ala ụbọchị 5 mgbe ị kwụsịrị duloxetine.
Na omumu ihe omumu ya na theophylline ochichi nke imegharia, ihe CYP 1A2 jiri duloxetine na 60 mg 2 ugboro kwa ubochi, odighi mgbanwe mgbanwe di omimi na pharmacokinetics ha. Nsonaazụ ndị a na-atụ aro na duloxetine bụ eleghi anya na ọ nwere mmetụta dị egwu na clinical na metabolism nke CYP 1A2 substrates.
Ebe CYP 1A2 na-etinye aka na metabolism nke duloxetine, ojiji nke duloxetine na-egbochi ndị na-egbochi CYP 1A2 nwere ike ibute mmụba nke duloxetine na plasma ọbara. Fluvoxamine (na dose nke 100 mg otu ugboro kwa ụbọchị), ịbụ onye na - egbochi ọrụ CYP 1A2, belata nkpuchi duloxetine na plasma ọbara n'ihe dị ka 77%. N'akụkụ a, mgbe ị na-edepụta duloxetine na CYP 1A2 inhibitors (ụfọdụ ndị na-egbochi antibacterial quinolone), ọ ga-adị mma ka ịdee duloxetine na obere ala.
Duloxetine bụ ihe mgbochi na-agbanwe agbanwe nke CYP 2D6. Mgbe ị na-edepụta duloxetine na 60 mg 2 ugboro kwa ụbọchị na otu ọgwụ desipramine, nke bụ mkpụrụ nke CYP 2D6, AUC nke desipramine na-abawanye ugboro atọ. Nlekọta oge nke duloxetine (na 40 mg 2 ugboro kwa ụbọchị) na-abawanye ụlọ ọrụ AUC nke tolterodine (2 mg ugboro abụọ n'ụbọchị) site na 71%, mana ọ naghị emetụta ọgwụ ọgwụ nke 5-hydroxyl metabolite. N'akụkụ a, a chọrọ ịkpachara anya mgbe ị na-edeba ndị na-egbochi CYP 2D6 duloxetine, nke nwere ntinye ọgwụgwọ dị warara.
Ebe CYP 2D6 na-ekere òkè na metabolism nke duloxetine, ojiji nke duloxetine na-egbochi ya na ndị na-egbochi CYP 2D6 nwere ike ibute mmụba nke duloxetine n'ọbara. Paroxetine (na dose nke 20 mg otu ugboro kwa ụbọchị) belata nkenke nke duloxetine na plasma ọbara dị ka 37%. N'akụkụ a, a chọrọ ịkpachara anya mgbe ị na-edepụta duloxetine na ndị na-egbochi CYP 2D6.
Mgbe ị na-edepụta duloxetine yana ọgwụ ndị ọzọ na-emetụta sistemụ akwara, karịsịa na usoro nke ime ihe, akpachara anya kwesịrị ịkpachara anya.
Duloxetine na - egbochi protein protein plasma (90%), yabụ, nchịkwa duloxetine na onye ọrịa na - a drugsụ ọgwụ ndị ọzọ na - ejikọ protein protein plasma n'ụzọ dị ukwuu nwere ike ibute mmụba nke ọgwụ ọ bụla.

Ngwakọta nke Duloxetine, mgbaàmà na ọgwụgwọ

Ihe akaebe banyere ogwu banyere duloxetine riri oke. Enwere ọnọdụ nke ịdoụ ọgwụ gabigara ókè (ihe ruru 1400 mg), gụnyere yana ọgwụ ndị ọzọ, mana ha edugaghị ọnwụ.
Na nyocha anụmanụ, sistemụ akwara azụ na eriri afọ ama ama gosiri isi ihe na-egbu egbu nke ịdoụbiga mmanya ókè. Ihe ndị a gụnyere mgbaàmà dị ka ịma jijiji, ụjọ agbụrụ, ataxia, vomiting, na anorexia.
Amaghị ọgwụ mgbochi a kapịrị ọnụ. Ozugbo ị doụbiga ya ókè, a na-egosipụta akwa larịị na ịhọpụta unyi nke arụ ọrụ. Gbaa mbọ hụ na ikuku. A na-atụ aro ka nyochaa ihe ịrịba ama ndị dị mkpa, ọrụ kadị, ọ bụrụ na ọ dị mkpa, usoro ọgwụgwọ na nkwado. Duloxetine nwere oke nkesa, yabụ na a na-eme ka diuresis, hemoperfusion na metabolism na-akpata ma ọ bụrụ na ịdoụbiga ihe ókè adịghị arụ ọrụ.

Njirimara kemịkal

Nkeji Duloxetine ka antidepressants site na otu nke nhọrọ nhọrọ reuptake inhibitors norepinephrine na serotonin.

Otito ihe mebere ya na - aru ​​ihe agha = 297.4 gram kwa mo.

A di ya na akpukpo aru na mbadamba, n’ime uzo nke 30 na 60 mg.

A na-ahụkarị n'ụkpụrụ hydrochloride.

Pharmacodynamics na pharmacokinetics

Ngwá ọrụ ahụ na-egbochi iweghachite ya serotonin na norepinephrine, akụkụ ụfọdụ - dopamine. N'ihi nke a, mkpụrụ ndụ akwara ndị a na - agbakọta, mmịnye ha na sistemụ akwara na - amụba. Ihe a na –eme ka ihe mgbu ghara idi, na - eme ka uzo nke ihe omimi di uto maka ya neuropathy.

A na-etinye ọgwụ ngwa ngwa mgbe nchịkwa ọnụ gasịrị. A na - enweta ihe kachasị n’otu n’ime ọbara n’ime awa abụọ. Nri nri yiri ogologo ga-eme ka oge ruru iru ịta kachasị ruo elekere 10. Ihe karịrị 90% nke ọgwụ ahụ na-egbochi protein ndị dị na plasma, albumin na glycoprotein. N'ime ndị ọrịa nwere ọrịa akụrụ na ọrịa imeju, ogo nke ijikọ protein protein adịghị agbanwe.

Duloxetine bụ metabolized, metabolites adịghị arụ ọrụ. 4-Hydroxyduloxetine Glucuronic Conjugate na 5-hydroxy-6-methoxyduloxetine sulfate conjugate kpụrụ akụrụ. Metabolism pụtara na ntinye nke CYP1A2 na CYP2D6. Ọkara ọkara nke ọgwụ ahụ bụ ihe dịka awa 11-12.

N'ime ụmụ nwanyị, mwepu nke metabolites na metabolism nke ọgwụ ji nwayọọ karịa ụmụ nwoke. Ọzọkwa, n'etiti ndị agadi na ndị ọrịa agadi, mpaghara n'okpuru usoro "oge itinye uche" na oge iwepụ ihe ahụ n'ahụ na-abawanye. Agbanyeghị, a naghị eme ndozi usoro onunu ogwu. Ọgwụ ọcha na-eduga n'ibelata ọgwụ. Na ogbo osisi gbasara akwara, ntinye uche kachasị okpukpu abụọ.

Ihe ngbanwe

Edere Duloxetine:

• ya na akuku glaucoma,
• na njikọta na MA inhibitors, Ndị na-egbochi CYP1A2,
• na allergies n'ihe a
• ndị ọrịa nwere nnukwu umeji,
• siri ike gbasara akwarandị ọrịa na ịba ọcha n'anya,
• ndị ọrịa anaghị achịkwa ọbara mgbali ike,
• n’oge ị na-enye nwa ara,
• ụmụaka na-erubeghị afọ 18.

Nsonaazụ

N'oge ọgwụgwọ a ọgwụ antidepressant na-etolite:

• isi ọwụwa, ịma jijiji, iro ụra, anya ntughari, paresthesia, ehighi ura, nrọ ndị doro anya,
• nchekasị, nkụda mmụọ, ọgbụgbọ,
• afọ ọsịsaọgbụgbọ, ọnya afọ, afọ mgbu,
• ịba ụba gas, ihe mgbu na mpaghara epigastric,
• agụụ mmekọahụ na-ebelata, enweghị ere, anorgasmia,
• tides, palpitations, tinnitus, belatara visual acuity, ime mkpọtụ,
• nkwarụ akwara, isi ike, mgbu na akwara na ọkpụkpụ, oke ahuhu, ọsụsọọ kachasị n’abalị
• enweghị agụụ, ịta ahụ oke, ike ọgwụgwụ.

Ọ dịkarịa ala, nsonaazụ ndị a nwere ike ime:

• ụjọ ụjọ, enweghị ike itinye uche, dyskinesiaenweghị mmasị bruxism,
• stomatitisili ozu ịba ọcha n'anyaụba ọrụ nke enzymes imeju,
• ngbaka, dysuria, nocturia, polyuriansogbu urination, belatara mmekọahụ ọrụ na ọchịchọ,
• eriri afọ, eriri afọ, nụrụ ụtọ mgbanaka, mmeghachi omume hypers,
• ịkụda mmụọ tachycardiaibelata ma ọ bụ mụbaa ọbara mgbaliAka na mkpịsị ụkwụ oyi,
• mydriasismgbu na ntị vertigoọbara nke imi, mmetụta nke nrụgide na akpịrị,
• hypersensitivity na ìhè, ọbara ọgbụgba, urticaria, ịkpọtụrụ dermatitisoyi, nnyapade ajirija, nkwanye akpukpo ahu,
• hyperglycemia (na ọrịa shuga), laryngitis, Arọ uru, akwusighi nke gait, akpịrị ịkpọ nkụ, fever, ntọt ke larịị phosphokinase creatine.

• omume obi ojoo ara ara, iwe, nsogbu,
• ọrịa serotonin, ịnwa igbu onwe, echiche igbu onwe, hallucinations,
• ume dị mma, ọbara ọgbụgba, ọgbụgba, ọdịda nke imeju, mgbanwe nke mmamịrị na akara nke menopause, nsogbu ọbara ọgbụgba,
• atrial fibrillation, supresventricular arrhythmia,
• mydriasis, glaucoma, trismus, akpịrị ịkpọ nkụ,
• hyponatremia, hypercholesterolemiamgbu na azụ azụ mmeghachi omume anaphylactoid.

Na -ebi nkọcha ihe oriri na-aputa ihe mwepu ọrịa: anya ntughariparesthesia ehighi ura, nrọ ndị doro anya, nchekasị, vom, ịma jijijiụba oke iwe vertigo na ọsụsọ.

Duloxetine, ntuziaka maka ojiji (Usoro na usoro onunu ogwu)

Ọgwụgwọ bidoro n ’ọgwụ were 60 mg, were ya otu ugboro n’ụbọchị. Mgbe ahụ ị nwere ike jiri nwayọ bulie usoro ọgwụgwọ ahụ gaa 0.12 g kwa ụbọchị (nke a na-ewere ya ugboro abụọ n'ụbọchị).

Na siri ike gbasara akwara Can nweghị ike ị thanụ karịa 30 mg nke ihe ahụ kwa ụbọchị. Site na imeju imeju, a na-ebelata usoro ọgwụgwọ mbụ ma belata ugboro nchịkwa.

Mmekorita

Mgbe ejikọtara ya na Duloxetine theophylline ọgwụ ọgwụ nke ọgwụ ikpeazụ anaghị agbanwe agbanwe nke ukwuu.

Iji ihe eji eme ihe na ndị inhibitors CYP1A2 nwere ike ibute ịba ụba n'ọbara plasma nke ọgwụ. Dịka ọmụmaatụ fluvoxamine na --ewe ike ịwepu plasma n'ihe dị ka 75%. A na-adụ ọdụ ịkpakọba ọgwụ desipramine, tolterodine na ụzọ ndị ọzọ na metabolism nke metụtara CYP2D6.

Ihe Ndị Nwere Ike igbochi CYP2D6 nwere ike ibute ịba ụba nke duloxetine.

N'iji nlezianya dị ukwuu, jikọta ọgwụ a na ọgwụ mgbochi ndị ọzọ, ọkachasị Paroxetine. Nwepu ya na-ebelata.

Nchịkọta ọnụ nke ụzọ na benzodiazepines, Phenobarbital, ọgwụ antipsychotic na antihistamines, na ethanol akwadoro.

Jiri mkpachapụ anya, jikọta ọgwụ ahụ na ọgwụ ndị nwere nnukwu nnabata na protein protein.

A na-atụ aro nke ukwuu ka ịghara ị thisụ ọgwụ a na nhọrọ ndị na-egbochiMAO, ọbụlagodi ndị na - agbanwe agbanwe MAO. moclobemide. Nke a nwere ike iduga mmepe. ọbara mgbali, myoclonusakwara anụ ahụ, mgbanwe dị nkọ n'ihe ngosipụta dị mkpa, Comarue ọnwụ.

Ejikọtara ọgwụ na ọgwụ anticoagulants na ọgwụ mgbochi antiplatelet na-eduga n'ọbara nke ọbara ọgbụgba. Mgbe ejikọtara ya na Warfarin INR nwere ike ibili.

Ọ na-esi ike ọrịa serotonin mgbe ị na-eji SSRI ndị ọzọ na ọgwụ. Ekwesịrị ịkpachara anya mgbe ị na-eji ọgwụ tricyclic antidepressants, Amitriptyline, clomipramine, Venlafaxine, hypericum, triptanam, pethidine, Tramadol na Tryptophan.

Nyocha Duloxetine

N'agbanyeghị nyocha ndị na-atọ ụtọ ndị dọkịta na-ekwu gbasara ọgwụ a, ndị ọrịa na-ekwu na ọ na-adịkarị iche. Ọtụtụ ndị mmadụ dere na anabataghị ọgwụ ahụ, mmetụta ndị dị njọ na-etolite, ọrịa nkwụghachi siri ike mgbe a kwụsịrị ọgwụgwọ, mmetụta ahụ na-abịa nwayọ, mgbe ụfọdụ mgbe ọtụtụ ọnwa nke nchịkwa gasịrị.

Nyocha ụfọdụ nke usoro Duloxetine:

• “... Nke a bụ ọgbọ ọhụrụ nke antidepressants, ọgwụ nwere mmetụta okpukpu abụọ, ọ na-enyere ndị ọrịa nwere ọrịa akwara ozi, obi nkoropụ, ihe mgbu, ma nwee oke ọnụọgụ ọgwụgwọ. Afọ ejuwo ndị ọrịa m họpụtara ya”,
• “... Anọ m na-a medicineụ ọgwụ kemgbe ihe fọrọ nke nta ka ọ bụrụ otu afọ ugbu a, enwere m ihu ọma na nsonaazụ ya - ha anọghị ebe ahụ. N’eziokwu, anwara m n’oge na-adịbeghị anya ịkwụsị ya iwere; Ugbu a ọ na-amalite ọzọ, ọ dabara m”,
• “... O furu oke ibu site na ọgwụgwọ a, isi ya na-ada ya mgbe niile. A na-emeso ihe niile, na-emeso ya, mana enweghị isi, amaghị m otu m ga-esi nọgide na-ebi ya”.

Mpempe usoro onunu ogwu

Usoro onunu ogwu 30 mg

Otu okpukpu okpu

duloxetine, pellets 176.5 mg, gụnyere: duloxetine hydrochloride 33.68 mg, gbakọrọ dị ka duloxetine 30 mg, hypromellose E5 (hydroxypropyl methyl cellulose) 10.54 mg, hypromellose HP55 (hydroxypropyl methyl cellulose) 15.51 mg, 52 mg, mannitol 47.3 mg, sodium lauryl sulfate 5.22 mg, sucrose 17.46 mg, titanium dioxide 1.15 mg, cetyl mmanya 1.55 mg,

Hard gelatin capsule Nke 3:

okwu - acha anụnụ anụnụ patted V, titanium dioxide, gelatin,

okpu - acha anụnụ anụnụ na-acha anụnụ anụnụ V, titanium dioxide, gelatin.

Usoro onunu ogwu 60 mg

Otu okpukpu okpu

duloxetine, pọọts 353 mg, gụnyere: duloxetine hydrochloride 67.36 mg, na usoro nke duloxetine 60 mg, hypromellose E5 (hydroxypropyl methyl cellulose) 21.08 mg, hypromellose HP55 (hydroxypropyl methyl cellulose) 31.02 mg, st 88 mannitol 94.6 mg, sodium lauryl sulfate 10.44 mg, sucrose 34.92 mg, titanium dioxide 2.3 mg, cetyl mmanya 3.1 mg,

Hard gelatin capsule Nke 1:

okwu - acha anụnụ anụnụ patted V, titanium dioxide, gelatin,

okpu - acha anụnụ anụnụ na-acha anụnụ anụnụ V, titanium dioxide, gelatin.

Mlọ ọgwụ

A na-etinye Duloxetine nke ọma mgbe a na-ewere ya ọnụ. Absorption na-amalite awa 2 mgbe ị takingụsịrị ọgwụ. Oke ịta (C_max) enwetara awa 6 mgbe ị takingụsịrị ọgwụ ahụ.

Iri nri anaghị emetụta ịta ọgwụ kachasị, mana ọ na-abawanye oge iji rute ịta ahụhụ kachasị (TS_max) site na awa isii ruo awa iri, nke na-ebelata ogo mmịpụta (ihe dịka 11%).

Duloxetine jikọtara nke ọma na protein plasma (> 90%), ọkachasị nwere albumin na ₁-acid glycoprotein, mana nsogbu nke imeju ma ọ bụ akụrụ anaghị emetụta ogo njikọ protein.

Duloxetine na-agbari ngwa ngwa na metabolites ya na-abụkarị nkere na mmamịrị. Abụọ CYP2D6 isoenzyme na CYP1A2 isoenzyme na-ejikọ ntọala nke metabolites abụọ (4-hydroxyduloxetine glucuronic conjugate, 5-hydroxy sulfate conjugate, 6-methoxyduloxetine).

Metabolmegharị metabolites enweghị ọrụ ọgwụ.

Nkera-ndu (T _1/2 ) Duloxetine bụ awa iri na abụọ. Nchịkwa nke duloxetine dị 101 l / h.

Otu ndị ọrịa n'otu n'otu

n'agbanyeghị eziokwu na ọdịiche dị na ọgwụ pharmacookinetics dị n'etiti ụmụ nwoke na ụmụ nwanyị (ọnụọgụ dị n'etiti duloxetine dị ala na ụmụ nwanyị), ọdịiche ndị a abụghị nnukwu nke na enwere mkpa idozi dose dabere na okike.

n'agbanyeghị eziokwu na ọdịiche dị na pharmacokinetics dị n'etiti ndị agadi dị n'etiti na ndị agadi amatala (mpaghara dị n'okpuru ntinye / usoro oge (AUC)) dị elu ma oge T _1/2 ọgwụ dị ukwuu na ndị agadi), ọdịiche ndị a ezughị iji gbanwee dose dabere naanị afọ ole ndị ọrịa dị.

n'ime ndị ọrịa nwere ajọ akụrụ oke (njedebe akụrụ gbasara akwara na - adịghị ala ala gbasara akụrụ)_max na AUC nke duloxetine mụbara ugboro abụọ. N'akụkụ a, a ga-atụle ike nke iwelata dose nke ọgwụ na ndị ọrịa nwere nsogbu gbasara ọrụ ezumike.

• Ọrụ imeju na-arụ ọrụ:

n'ime ndị ọrịa nwere akara akwara nke imeju afọ, enwere ike ịhụta mbelata metabolism na mwepụ nke duloxetine. Mgbe otu ọgwụ were 20 mg nke duloxetine dị na mmadụ isii nwere ọrịa imeju na-arụ ọrụ imeju na-adịghị arụ ọrụ (Klas B n'ọtụtụ Childmụaka). _1/2 Duloxetine dị ihe dịka 15% dị elu karịa ndị nwere ahụike otu nwoke na afọ na mmụba okpukpu ise na mkpughe. N'agbanyeghị eziokwu ahụ C_max n’ebe ndị ọrịa nwere ọrịa cirrhosis bụ otu ndị ahụ siri gbasie, T _1/2 bụ ihe dị ka ugboro atọ.

• Obi erughị ala
• Painfuldị na-egbu mgbu nke ịrịa ọrịa ụkwara akwara,
• Ọrịa aghara aghara,
• Ọrịa mgbu na-egbu oge nke akwara ọkpụkpụ (gụnyere nke fibromyalgia kpatara, ọrịa buolevoy na-adịghị ala ala na azụ ala yana osteoarthritis nke nkwonkwo ikpere).

Ime na lactation

N'ihi enweghị ezughi oke na duloxetine n'oge afọ ime, ekwesịrị ị theụ ọgwụ ahụ naanị ma ọ bụrụ na uru nne na nna ga-aba karịa ka ọ nwere ike ibute nwa ebu n’afọ. E kwesiri ịdọ ndị ọrịa ọdụ na n ’ime ahụ ma ọ bụ na-eme atụmatụ ịtụrụ ime n’oge ọgwụgwọ Duloxetine, ha kwesiri ịgwa dọkịta ha.

Ihe akaebe nke ọrịa na-egosi na ojiji nke nhọrọ serotonin reuptake inhibitors (SSRIs) n'oge afọ ime, ọkachasị n'ọgba ndị ikpeazụ, nwere ike ịbawanye ohere nke ọbara ọgbụgba na-adọkarị nwa amụrụ ọhụrụ. N'agbanyeghi enweghi nyocha banyere njikọta ọbara ọgbụgba na-adịgide adịgide na ụmụ amụrụ ọhụrụ na ojiji nke SSRIs, a gaghị ewepụ ihe ize ndụ ahụ, nyere usoro nke duloxetine (mgbochi nke serotonin reuptake).

Dika esi ahuta ogwu ndi ozo nke serotonergic, achoputara oria “nloghachi anya” umu ohuru n’ahia nke nne jiri duloxetine n’azu ime. Ọrịa “nkwụghachi” ahụ gụnyere mgbaama ndị a: ọbara mgbali ala, ịma jijiji, ụba neuro-reflex irritability syndrome, ihe isi nri nye nri, nsogbu iku ume, cramps. Achọpụtara ọtụtụ ihe mgbaàmà n’oge ịmụ nwa ma ọ bụ n’ụbọchị ndị mbụ a mụchara nwa.

N'ihi eziokwu ahụ na duloxetine na-abanye na mmiri ara ara (nsonye nke nwa ebu n’afọ bụ ihe dịka 0.14% nke ndọta nne dabere na mg / n'arọ ibu) anaghị atụ aro inye nwa ara n'oge a na-eji duloxetine akwado ya.

Usoro onunu ogwu na nhazi

N'ime. A ga-eloghari okpu ahihia kpamkpam na-enweghị ịta ma ọ bụ ịkụda mmụọ. Etinyekwala ọgwụ ahụ n’ihe oriri ma ọ bụ gwakọta ya na mmiri ọ asụ ,ụ, n’ihi na nke a nwere ike imebi ihe mkpuchi mkpụrụ osisi.

Usoro akwadoro ọgwụ mbụ bụ 60 mg 1 oge kwa ụbọchị, n'agbanyeghị nri.

N'ime ụfọdụ ndị ọrịa, iji mepụta nsonaazụ dị mma, ọ dị mkpa ịbawanye ọgwụ site na 60 mg otu ugboro kwa ụbọchị gaa na ọnụọgụ 120 mg kwa ụbọchị na usoro abụọ kewara abụọ. Nhazi usoro nke iji ọgwụ a n ’ọgwụ were ihe karịrị 120 mg.

N'ime ndị ọrịa nwere ọdịda akụrụngwa:

ogwu mbu kwesiri ibu 30 mg otu ugboro kwa ụbọchị na ndi ọrịa nwere ajọ akụrụ oke (ngwụcha ngwụcha CRF, nwechapụ ihe 10%)

oge ọ bụla - 1/100 nhọpụta (> 1% na 0.1% na 0.01% na 15.

N’oge na-adịghị anya: hyperglycemia (nke a na-ahụkarị na ndị ọrịa nwere ọrịa mellitus).

N’oge na-adịghị anya: akpịrị ịkpọ nkụ, hyponatremia, ọrịa nke ezughi oke nke hormone antidiuretic 6.

Ihe a na-ahụkarị: ehighi ura 11.

Ọtụtụ mgbe: mkpali 10, nchekasị, nrọ 20 na-adịghị ahụkebe, belata libido (gụnyere ọnwụ libido), mkpịsị nke orgasmia (gụnyere anorgasmia).

Na-enweghị oge: echiche igbu onwe 5,22, nsogbu ịrahụ ụra, bruxism, disorientation 19, enweghị mmasị.

Oge na-adịghị anya: omume igbu onwe 5,22, nkụchi ara, ịtụ ilu, oke iwe na ibu iro 4.

Ọrịa nke sistem

Ọtụtụ mgbe: ọgbụgbọ, isi ọwụwa, iro ụra 12.

Ọtụtụ mgbe: jijiji, paresthesia 18.

N’oge na-adịghị anya: myoclonus, akathisia 22, ịba ụba oke mgbakasị ahụ, ntị na-adịghị ala ala, ike ọgwụgwụ, dysgeusia, dyskinesia, ọrịa ụkwụ na-adịghị ala ala, belata ogo ụra.

N’oge na-adịghị anya: ọrịa serotonin 6, nkwarụ nke 1, mkpali psychomotor 6, nsogbu extrapyramidal.

Mmebi nke akụkụ nke ọhụụ

Ọtụtụ mgbe: ọhụhụ na-adịghị mma.

Na oge adighi anya: mydriasis, enweghi ike ihu ihe.

Ọ na-adịkarị: glaucoma, anya akọrọ.

Mmetụta ntị na nkwarụ labyrinthine

Ọtụtụ mgbe: tinnitus 1.

Ugboro ugboro: vertigo, ọnya afọ.

Ọrịa obi

Ọtụtụ mgbe: palpitations.

Na oge na-adighi anya: tachycardia, arrhythmia supraventricular, tumadi nke atrial fibrillation.

Ọrịa vaskụla

Ọtụtụ mgbe: hyperemia (gụnyere ọkụ ọkụ).

N’oge na-adịghị anya: ọbara mgbali 3.22, ọbara mgbali elu 3.14, nsọtụ oyi, orthostatic hypotension, gwụ afọ.

Na oge na-adịbeghị anya: nsogbu ọgbụgba ọbara 3.6.

Ọkpụkpụ nke sistem, obi na akụkụ akụkụ ahụ

Ọtụtụ mgbe: imegharị ụda, mgbu na oropharynx.

N’oge na-adịghị anya: mmetụta nke agbụ na akpịrị, imi.

Ọrịa ọgbụgba

Ọtụtụ mgbe: akpọnwụ akpọnwụ (12.8%), ọgbụgbọ (24.3%), afọ ntachi.

Ọtụtụ mgbe: afọ ọsịsa, vomiting, dyspepsia (gụnyere ahụ erughị ala), flatulence, mgbu nke afọ 9.

N’oge na-adịghị anya: eriri afọ afọ 7, eriri afọ, afọ, eriri afọ, dysphagia.

N’oge na-adịghị anya: stomatitis, halitosis, hematochesia.

Nmebi nke imeju na ọnya biliary

N’oge na-adịghị anya: ịba ọcha n’anya nke 3, nnukwu mmebi imeju.

N’oge na-adịghị anya: ọdịda imeju 6, jaundice 6.

Ọkpụkpụ nke anụahụ na anụ ahụ dị n'okpuru ala

Ọtụtụ mgbe: ịba ụba ịsụgharị, ihe ọkụ ọkụ, itching.

N’oge na-adịghị anya: ọsụsọ n’abali, urticaria, ọrịa kọntaktị, ọsụsọ oyi, eserese, ịba ụba nke ọnya.

Ikebịghike: Stevens-Johnson syndrome 6, angioedema 6.

Ọ na-adịkarị obere: nsị anụ ahụ.

Ọkpụkpụ akwara na uru ahụ

Ọtụtụ mgbe: uru ahụ, uru akwara iri na isii, akpụ akpụ.

Na oge adighi anya: ogwe olu.

Mmebi nke akụrụ na eriri afọ

Ọtụtụ mgbe: ịba ụba urination.

N’oge na-adịghị anya: njigide urinary, dysuria, nsogbu ịmalite urination, nocturia, polyuria, belatara mmụba mmamịrị.

Eljọ: mmamịrị na-enweghị atụ nke mmamịrị.

Mmebi nke akụkụ anụ ahụ na mammary gland

Ọtụtụ mgbe: dysfunction erectile.

N’oge na-adịghị anya: imebi ejaculation 21, ejaculation nke na-egbu oge, mmerụ nwoke na nwanyị, ọbara ọgbụgba, ọgbụgba oge, mgbu na agba.

N’oge na-adịghị anya: mgbanwe nke menopause, galactorrhea, hyperprolactinemia.

Ọrịa na nkwarụ izugbe na saịtị ịgba ahụ

Ọtụtụ mgbe: ike ọgwụgwụ 13.

Ọtụtụ mgbe: ọdịda 8, gbanwee na ụtọ.

N’oge na-adịghị anya: mgbu obi 22, ihe mmetụta na-enweghị isi, agụụ, akpịrị ịkpọ nkụ, nju oyi, ọgbụgba, mmetụta nke okpomọkụ, mgbaru isi.

Laboratory na akụrụngwa data

Ọtụtụ mgbe: oke ibu.

N’oge na-adịghị anya: ịba ụba, ịba ụba nke alanine aminotransferase (ALT), aspartate aminotransferase (ACT), alkaline phosphatase, gamma-glutamyl transpeptidase, bilirubin, creatine phosphokinase, nje na-efe efe nke ọnya enzymes, ịba ụba ịta potassium na ọbara.

Ọria: mmụba n'ọbara nke cholesterol n'ọbara.

1 Achọpụtakwara ọrịa ọdụdọ na tinnitus mgbe emechara ọgwụgwọ na duloxetine.

2 Achọpụtara hypotension na mmekọrịta nke Orthostatic karịsịa na mmalite ọgwụgwọ.

3 Lee “Ntụziaka pụrụ iche”.

4 Ekwuru okwu banyere mbuso agha na ibu iro ọkachasị na mbido ọgwụgwọ nke duloxetine ma ọ bụ mgbe emechara ya.

5 Achọpụtara oge echiche igbu onwe ya ma ọ bụ omume igbu onwe ya n'oge a na-eji duloxetine ma ọ bụ n'oge mmalite mgbe ọ gbasịrị ọgwụgwọ.

6 Ogologo oge nke mmeghachi omume ojoo. Achọpụtaghị n'oge ọnwụnwa nke ụlọ ọgwụ.

7 Ọzọkwa ọbara ọgbụgba metụtara ọbara ọgbụgba, ọbara ọgbụgba site na obere eriri afọ, ọgbụgbọ ọbara, ọbara ọgbụgba, melena, ọnya afọ, ọbara ọgbụgba.

8 Falls bụ ihe a na-ahụkarị n’oge agadi (≥ 65 afọ).

9 Gụnyere ihe mgbu na elu afọ na ala, erughị ala nke oghere ihu, mgbakasị ahụ, mgbu afọ.

10 Gụnyere egwu n’ime, ụjọ nchegbu, esemokwu, nsogbu uche.

11 Gụnyere teta na etiti abalị, iteta n'ụtụtụ, ịrahụ ụra.

12 Gụnyere hypersomnia, ọgbụgbọ.

13 gụnyere asthenia.

14 Gụnyere mmụba nke mgbali ọbara systolic, nsogbu diastolic, mgbali systolic, ọbara ọgbụgba, ọbara mgbali elu.

15 gụnyere anorexia.

16 Yiri akwara olu.

17 gụnyere myalgia na olu mgbu.

18 gụnyere hypesthesia, hypesthesia nke ihu, ọrịa hypesthesia akụkụ akụkụ, paresthesia a na-ahụkarị, adịkarịghị ala (19 gụnyere ọgba aghara.

20 Gụnyere ụra abalị.

21 Gụnyere enweghị ebu ibu.

22 Onweghi ihe di iche na placebo.

Withdọrọ duloxetine (ọkachasị n'otu oge) na - edugakarị n'ọrịa “nloghachi”, nke gụnyere ihe mgbaàmà ndị a: ọgbụgbọ, ọgba aghara (gụnyere paresthesia), nsogbu ụra (gụnyere ehighị ụra nke ọma na nrọ doro anya), adịghị ike, ụra, iwe ma ọ bụ nchekasị, ọgbụgbọ na / ma ọ bụ ọgbụgbọ, ịma jijiji, isi ọwụwa, mgbakasị ahụ, afọ ọsịsa, hyperhidrosis, na vertigo.

Na mkpokọta, mgbe ị na-ewere SSRIs na serotonin na norepinephrine reuptake inhibitors (SSRIs), ihe ịtụnanya ndị a nwere adịghị ike ma ọ bụ agafeghị oke na agwa ha. Agbanyeghị, na ụfọdụ ndị ọrịa, ihe ịtụnanya ndị a nwere ike ịka njọ ma ọ bụ ogologo oge.

Site na nchịkwa nwa oge nke duloxetine (ruo izu iri na abụọ), ndị ọrịa nwere ụdị mgbu ọria neuropathy na-egbu mgbu gosipụtara ntakịrị mmụba na glucose ọbara na-ebu ọnụ mgbe ha na-agbaso ịba ọcha n'anya glycosylated, ma na ndị na-ewere duloxetine na otu placebo. Site na ọgwụgwọ ogologo oge na duloxetine (ruo izu 52), enwere ntakịrị mmụba na mkpokọta gemocosylated haemoglobin, nke 0.3% dị elu karịa mmụba nke njikọ kwekọrọ na ndị ọrịa na-enweta ọgwụgwọ ọzọ. Banyere glucose na-ebu ọnụ na cholesterol zuru oke n'ime ọbara, ndị ọrịa na-ewere duloxetine gosipụtara ntakịrị mmụba na njirimara ndị a ma e jiri ya tụnyere ntakịrị mbelata nke ahụ na-ahụ maka njikwa ndị ọrịa.

Ngbanwe emere (dika onodu obi ya) Oge ntunye QT na ndi oria na - ewere duloxetine adighi iche na nke ahu. Enweghị ọdịiche dị ukwuu dị n'etiti ọgwụgwọ n'etiti QT, PR, QRS, ma ọ bụ QTcB n'etiti ndị ọrịa na-ewere duloxetine na otu placebo.

Duloxetine - ntuziaka maka ojiji, nyocha nke ọgwụ na analogues

Duloxetine, ọgwụ nke ọgbọ nke atọ, bụ ihe na - egbochi ihe serotonin na norepinephrine reuptake. N'adịghị ka ọgwụ psychotropic nke ọgbọ nke mbụ na nke abụọ, Duloxetine anaghị emetụta ndị ogbugbo niile nke ụbụrụ. Ọgwụ a na - ahọrọ iweji 5-hydroxytryptamine, dopamine na norepinephrine, ebe ọ bụ na ọgba aghara n'ọrụ ha na-akpata ịda mba.

Ogwu ahu bu ihe ohuru nke ogwu ogwu nke n’enweghi nsogbu nke hypnotic. Dabere na ntuziaka ahụ, Duloxetine nwere obosara ma bụrụ nke a na-ewere dị ka ọgwụ hettecyclic psychotropic kasị dịrị nchebe. Nke mbu, a na-eji Duloxetine na psychiatry iji gwọọ nsogbu ọgbụgba.

Ntuziaka maka iji Duloxetine: usoro ọgwụgwọ na usoro maka mbanye

Dabere na ntuziaka ahụ, ekwesịrị ịmalite 60 ọgwụ nke Duloxetine kwa ụbọchị. Site na iji usoro a, a na-a theụ ọgwụ ahụ oge 1 kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, a na -ebilata usoro ahụ ruo 120 mg, mana a ga-ekebi ọnụọgụ nke ihe a ka usoro onunu abụọ. A naghị atụ aro ka ọ rie ihe karịrị 120 mg nke ọgwụ kwa ụbọchị.

A na-enye ndị ọrịa nwere ọnụego mkpochasị maọbụ ọnụ ahịa 30 mg nke ihe ahụ kwa ụbọchị. Site na nsị imeju, a ga-ebelata usoro mbido nke ọgwụ na - egbochi ma ọ bụ nwekwuo ohere ị forụ ọgwụ ahụ.

Usoro usoro ọgwụgwọ maka ndị ọrịa agadi adịghị iche.

Emere ngwaahịa a maka ojiji. Mbadamba ụrọ na agbanyeghị nri, a ga-eji obere mmiri were ya were mmiri rie ha. A ga-ezere mmebi nke capsules.

Kwụsị iji nwayọọ nwayọọ kwụsị ọrụ, ihe karịrị ụbọchị iri na anọ. Esskwụsị ọgwụ ga - eme ka ọnọdụ onye ọrịa ka ọ daa.

Amachibidoro ị abuseụbiga mmanya ókè. N'oge ọgwụgwọ Duloxetine, akpachara anya kwesịrị igosipụta mgbe ị na-anya ụgbọ ala na ihe omume ndị ọzọ nwere ike ịdị ize ndụ.

Nsonaazụ

Onu ogwu a choro iji mee ihe ojoo bu ihe ndi mmadu mebere, ma dabere na ikike idi ahu.

Duloxetine, dị ka ọgwụ mgbochi ọrịa heterocyclic ndị ọzọ, adịghị emerụ emerụ karịa tricyclic, mana nsonaazụ ndị ọzọ yiri:

• enwere ike igba ọrịa ma ọ bụrụ na ị ofụ ọgwụ ogologo oge, mana ihe ọghọm dị ntakịrị,
• ogwuura ogwugwu (ura, agwa agwa, iju ike, nti na ebe nchekwa)
• Ihe mkpali CNS (nsogbu ura, iwe, nchekasị) na-etolite nzụlite nke iji ogologo oge ma ọ bụ iwepu ọgwụ ọjọọ, ihe egwu dị ala,
• orthostatic hypotension nwere ike ime (n'ihi ihe alpha na-egbochi ihe), ihe egwu dị ala,
• A na-egosikwa ọrụ M-anticholinergic obere oge (akpọnwụ akpọnwụ, peristalsis, njigide urinary, nsogbu obibi, ịba ụba intraocular pressure, tachycardia).

Maka ndi di ime na ndi ara

Enwere ike ịkọwa ọgwụ mgbochi n'oge afọ ime naanị mgbe uru dị na akụrụngwa karịrị ihe ize ndụ nwatakịrị, nke a bụ n'ihi enweghị ahụmịhe ahụike na ndị ọrịa n'ọnọdụ ahụ. Ọ bụrụ na nwanyị chọrọ ime ma ọ bụ na ọ bịara, mgbe ahụ ị ga-eme ka dọkịta gị mata.

Nri ahụ na-arụ ọrụ na-abanye n'ime mmiri ara ara amaghi, yabụ na-atụ aro ka ị nyefee na nri anụ aka n'oge a na-enye nwa.

Njirimara ngwa

A naghị atụ aro ka ị gafere karịa usoro ọgwụ kwa ụbọchị nke 0.12 grams.

Imeghari usoro onunu ogwu di nkpa n’oge ọgwụgwọ nke ndị ọrịa nwere akụrụ gbasara akwara na-adịghị ala ala na imeju imeju.

A na - eji nwayọ wepụ ọgwụ ọjọọ, enwere nnukwu ihe ize ndụ nke mwepu ọrịa.

Mgbe ị theụsịrị ọgwụ ahụ, ọ nweghị mmebi nke mmeghachi omume psychomotor, ebe nchekwa na ọrụ ọgụgụ isi ndị ọzọ, mana ụra na-apụtakarị. N'ihi ya, ịnya ụgbọ ala na ịme ihe nwere ike ibute adịghị atụ aro ya.

Uzo di iche

Akara zuru oke nke Duloxetine - Symbalta.

Antidepressants gụnyere:

1. Paxil
2. Amitriptyline,
3. Fluxonil
4. Sinekwan,
5. Voxemel
6. Zoloft
7. Venlafaxine
8. Phloxet
9. Ọtọ
10. Citalopram,
11. Rexetin
12. Gelarium
13. Flunisan
14. Portal
15. Fevarin,
16. Citalift,
17. Lenuxin,
18. Siozam
19. Maprotibene
20. Efevelon
21. Asafen
22. Mirzaten
23. Stimuloton
24. Brintellix
25. Miracitol
26. Elicea
27. Egburu
28. Tsipralex,
29. Ndabere,
30. Coaxil
31. Họrọ,
32. Amizole
33. Newwell,
34. Elivel
35. Ndị mmadụ
36. Prodep
37. Okpokoro
38. Thorin
39. Valdoxan
40. Duloxetine
41. Tsipramil,
42. Azona
43. Asentra
44. Ọrụ
45. Clomipramine,
46. Miansan
47. Imipramine
48. Noxibel
49. Remeron
50. Neuroplant
51. Fluoxetine,
52. Escitalopram
53. Oprah
54. Alventa
55. Heparetta
56. Cytol,
57. Xel
58. Egwuregwu Esprital
59. Serlift,
60. Rimda mba
61. Umo,
62. Paroxetine
63. Calixta
64. Dupfix
65. Velaxin,
66. Aurorix
67. Heptor.

Mwepụta wepụtara ya na ihe mejupụtara

Sdị usoro onunu ogwu Duloxetine canon - mkpụrụ osisi enteric: nha Nke 3 (30 mg) ma ọ bụ Nke 1 (60 mg), gelatin siri ike, nwere ahu na mkpuchi nke acha anụnụ anụnụ, ọdịnaya - microspheres gbara gburugburu site na ọ fọrọ nke nta ka ọ chachaa na agba ọcha (7, 10) , Pọọsụ 14 ma ọ bụ 15. N'ime blisters, na mkpọ nke kaadiboodu 1, 2 ma ọ bụ 4 nke 7 capsules, ma ọ bụ ngwugwu 2, 3 ma ọ bụ 6 nke capsules 10, ma ọ bụ ngwugwu 1, 2 ma ọ bụ 6 nke capsules 14, ma ọ bụ 2 ma ọ bụ 4 ngwugwu nke capsu 15).

Ngwakọta 1 Capsule:

• ihe na-arụ ọrụ: duloxetine - 30 ma ọ bụ 60 mg,
• Ihe ndị na-adịghị arụ ọrụ: titanium dioxide, mannitol, stachi, mmanya cetyl, sodium lauryl sulfate, sucrose, hypromellose HP55 (hydroxypropyl methyl cellulose), hypromellose E5 (hydroxypropyl methyl cellulose),
• Ihe mejuputara Capsule: gelatin, titanium dioxide, patent blue dye V.

Ihe omuma banyere ogwu Duloxetine

A na-eji Duloxetine mee ihe iji kpochapụ ịda mbà na mgbu n'oge neurosis. Ọgwụ ahụ na-egbochi iwere mmiri nke norepinephrine na serotonin site na adrenergic neurons (na-egbochi iweghachi homonụ ndị a). Ọgwụ nwere mmetụta na-adịghị ike na njide dopamine. Ihe dị ike na-egbochi ihe mgbu siri ike na nsogbu akwara ozi.

Ndị na-ahụ maka ọgwụ, INN, akporo

Ndị ụlọ ọgwụ na ọgwụ ọgwụ nke ọgwụ mgbochi bụ ọgbọ nke atọ. Aha mba ụwa na-akwadoghị bụ Duloxetin (Duloxetinum). A na-eji ọgwụ ahụ eme ihe maka ọrịa ọnya ọ bụla nke nsogbu ụjọ akwara na nsogbu ọnọdụ uche dị iche iche. N'ihi oke arụmọrụ ya yana adịghị mma o metụtara, ọgwụ a enwetala ọtụtụ ọgwụ ọgwụ.

Mwepụta mwepụta na ọnụahịa maka Duloxetine Canon

A na-eme Duloxetine n'ụdị nke capsules gelatin na-acha anụnụ anụnụ ma ọ bụ na-acha anụnụ anụnụ. N’egede mmiri nke ọ bụla, a na-eji ihe dị ka mmiri e ji eme mmiri ọgwụ (30 ma ọ bụ 60 mg) na nọmba njirimara (9543 ma ọ bụ 9542). Capsules juputara na akwa ọcha na-acha ọcha ma ọ bụ isi awọ.

Ego ọgwụ Duloxetine Canon, nke ụlọ ọrụ Russia Canonfarm Production mepụtara:

Akụkụ nọ n'ọrụ na mejupụtara ọgwụ ahụ bụ ihe dị na duloxetine hydrochloride, nke na-egbochi usoro ihe mgbu na-emetụta ihe mgbu. Na mgbakwunye na ntinye aka nke nọ n'ọrụ, ihe mejupụtara capsules gụnyere ihe ndị ọzọ:

• nri agba agba E171,
• mannitol
• amylose na amylopectin polysaccharides,
• ọkọlọtọ
• sodium dodecyl sulfate,
• okpete
• hypromellose HP55,
• protein protein na-arụ ọrụ hydrolyzezed
• nri mgbakwunye E131.

Ihe ngosi na contraindications Duloxetine

Ihe ngosiputa maka iji ogwu a.

• nsogbu nke ọrịa shuga nke sistemụ akwara ozi
• ịda mba

Ndepụta nke contraindications dịkwa obere. Ejiri ọgwụ ahụ maka:

• ọgwụ ịgwọ ọrịa
• N'otu oge na ọgwụ mgbochi na-egbochi enzyme monoamine oxidase.

Ekwesịrị ịkpachara anya na ndị ọrịa nwere mgbaàmà ndị a:

• echiche igbu onwe ya
• ntụgharị uche manic,
• akụkọ ihe mere eme nke ọdịdọ
• nnukwu nkuku glaucoma,
• akụrụ na akwara imeju,
• ọbara mgbali ike.

Na mgbakwunye, a naghị atụ aro ị theụ ọgwụ maka ndị ọrịa afọ ha erughi afọ 18, ebe enweghi data banyere ịdị mma na nchekwa nke ojiji nke Duloxetine site na ndị ọrịa nke otu a. Maka otu ihe ahụ, edeghị ọgwụ ahụ n’oge mmegharị ahụ na ara.

Mmetụta dị n'akụkụ duloxetine na ịdoụbiga mmanya ókè

N'ime ndị ọrịa na-a takingụ Duloxetine, nnabata ọ drugụ ọgwụ dị mma. Mmetụta ndị dị na ya na-apụta nke a na-anaghị ahụkebe ma ọ bụ na-amalite na mmalite nke ọgwụgwọ, ma emesịa burufe nke ha. Mana, na ọdịdị nke mgbaàmà ndị a, ị ga-agakwuru dọkịta ka ọ gbanwee ọgwụgwọ ahụ:

• afọ ntachi
• ọgbụgbọ
• xerostomia,
• anya ntughari
• adighi ike
• ehighi ura
• hyperomnia,
• cephalgia
• mmụba n'obi,
• mgbaze siri ike ma na-egbu mgbu.
• vomiting
• nri riri
• Aka na-ama jijiji
• mbelata na mmeghachi omume,
• ọsụsọ
• mmetụta nke okpomoku
• nkpu
• agụụ mmekọahụ
• ihe mgbu nke afọ na eriri afọ,
• mmebi nke mucosa onu,
• ọbara mgbali elu
• I nweta ibu
• uru ahụ
• nụrụ ụtọ ọgba aghara,
• mmebi anya
• moto ụjọ
• njigide urinary
• ubara ihe ngosi nke alanine aminotransferase, aspartate aminotransferase na creatine phosphokinase.
• ụba intraocular mgbali,
• ọrịa imeju nke mkpali, ọrịa Ozioma,
• mmeghachi omume anaphylactic,
• mmebi nke mmiri-electrolyte itule,
• akpụkpọ pathologies na anụ na mucous akpụkpọ ahụ,
• Isi awọ nke Quincke, rashes na akwara na mucous membranes, urticaria,
• mbelata nke ọbara mgbali elu na nkụda mmụọ.

Nsonaazụ na-egbu egbu n'ihi ịkarị ọgwụ a tụrụ aro ka achọpụtara bụ naanị ọgwụ nkwonkwo ya na ọgwụ ndị ọzọ.

Do Overụbiga ókè ókè bụ ihe ndị a:

• hyperomnia,
• mgbu n'ime olulu afọ, vom,
• nkwanye akwara
• mmụba n'obi,
• Coma.

Bụrụ na ị doụbiga ya ókè, a na-atụ aro ka ọ rụọ ọrụ mgbochi afọ ma were unyi na-arụ ọrụ iji belata nnabata nke ihe ahụ. N'ọnọdụ ndị siri ike, a na-atụ aro ịga ụlọ ọgwụ.

Echiche nke ndị dọkịta

Ndị dọkịta na-ele ọgwụ a anya dị ka ihe dị mma ma dị ọnụ ala karịa maka ọgwụ mgbochi mba ọzọ. N'ụzọ bụ isi, ha na-ahapụ nyocha dị mma banyere ọgwụ:

1. Savenko L. M., onye isi mgbaka: “Ndị ọrịa na-a drugụ ọgwụ a na-adị ndụ n'anya anyị. Ha na-aghọọkwu igwe na ntụkwasị obi. E jiri ya tụnyere ndị mba ọzọ, Duloxetine adịghị ọnụ, yabụ ana m ede ya ndị ọrịa, ọkachasị ndị okenye. ”
2. Rogachevsky R. Yu., Psychiatrist: “Ọgwụ a dị ala karịa ụdị ọgwụ mgbochi ndị ọzọ na arụmọrụ, mana o nwekwara obere mmetụta na-adịghị mma. "Ngwọta ahụ na-enyere aka na ịda mbà n'obi, mana ọ na-emetụta mbibi na ịgafe steeti hypomanic na Duloxetine."

N'ihi ya, ndị dọkịta hụrụ ịdị irè nke ọgwụ n'ọgụ megide ịda mbà n'obi. Ma enwere nsogbu nsogbu uche karịa, ọ nwere ike ịdị mkpa iji ọgwụgwọ ọzọ.

Nyocha nyocha Ndidi

Nyocha nke ndị ọrịa na-a theụ ọgwụ anaghị adị mma mgbe niile. Ọtụtụ na-achọpụta mmetụta ndị na-apụta site n'ịgwọ ọgwụ na enweghị ike ya. Ndị ọzọ, n'ụzọ megidere, na-ahụ mmetụta dị mma nke ọgwụ na ịnagide ihe dị mfe:

1. Diana, onye dị afọ 22: “Achọpụtara m mmetụta na-adịghị mma nke ọgwụ naanị na mmalite ọgwụgwọ. Ka oge na-aga, enweghị ngosipụta na-adịghị mma bilitere. Mmetụta ọgwụ antidepressant gosipụtara onwe ya ngwa ngwa: akwara na-apụ kwa ụbọchị, enwere olileanya maka ihe kachasị mma. Agbanyeghị, mgbe m kwụsịrị ọgwụ, ahụrụ m ọrịa “mwepụ”, ọ bụ ezie na e belatara nke nta nke nta.
2. Peter, onye dị afọ 32: “Ọgwụ ahụ nyere aka belata ihe mgbaàmà nke fibromyalgia: ihe mgbu belatara nke ukwuu, ịda mbà n'obi wee pụọ, ọ bịara dịkwuo mfe itinye uche. Ka o sina dị, ọgwụ ahụ riri m ahụ nke ukwuu ma n'oge na-adịghị anya ọgwụ ahụ kwụsịrị inye aka. ”

Duloxetine bụ ọgwụ mgbochi ụlọ nke na-anagide nkụda mmụọ nke ụdị dịgasị iche iche. Ọ dị mkpa iji nlezianya were usoro ọgwụgwọ a, ebe ọ na-akpata ihe riri ahụ na "nkwụsị" ọrịa. Tupu ojiji, ọ dị mkpa ịkpọtụrụ dọkịta.

Ihe ngosi maka ojiji

• nsogbu ịda mba
• juputara nchekasị ahuhu,
• ụdị mgbu nke neuropathy ọrịa mamịrị,
• ọrịa mgbu na-adịghị ala ala nke akwara ọkpụkpụ, gụnyere na ala azụ, yana osteoarthritis nke nkwonkwo ikpere na n'ihi fibromyalgia.

Ntuziaka maka iji Duloxetine Canon: usoro na usoro onunu ogwu

A na-egosi Duloxetine Canon maka iji ọnụ mee ya. A ga-elorịrị okpu ahihia kpamkpam, na-enweghị nkụ, na-ata ata.Iri nri anaghị emetụta ịdị irè nke ọgwụ a, mana ekwesighi ịgwakọta agbụ na mmiri ma ọ bụ tinye ya na nri, ebe ọ bụ na mbibi membrane ahụ ga-ekwe omume.

Na nmalite ọgwụgwọ, a na-enyekarị 60 mg otu ugboro kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, mee ka dose ahụ dị 60 mg 2 ugboro kwa ụbọchị.

Ndị ọrịa nwere ọrịa cirrhosis ga-ebelata ọgwụ mbido ma ọ bụ belata ugboro ole nchịkwa.

Usoro izizi nke Duloxetine Canon maka ndị ọrịa nwere nnukwu ọrụ na-arụ ọrụ na-arụ ọrụ nke ukwuu (mwepụta creatinine 10%, ọtụtụ mgbe site na> 1% ka 0.1% ruo 0.01% gaa

Duloxetine canon: ọnụ ahịa dị na ahịa ọgwụ dị n'ịntanetị

Duloxetine Canon 30 mg enteric-soluble capsules 14 pcs.

DULOKSETIN CANON 30mg 14 PC. okpu ekpenta

Duloxetine Canon 60 mg Capsule, enteric, 28 PC.

DULOKSETIN CANON 60mg 28 PC. okpu ekpenta

Duloxetine Canon Caps. Ksh / sol 60mg n28

Mmụta: Mahadum Ahụike Rostov State, ọpụrụiche "General Medicine".

A na - emejupụta ozi gbasara ọgwụ ahụ, enyere ya aka ka ọ nweta ihe ọ bụla, ọ naghị edochi ntuziaka gọọmentị. Medication medicationụ onwe gị ọgwụ dị ize ndụ nye ahụ ike!

Ọbara mmadụ "na-agabiga" n'ime arịa ndị nọ n'okpuru nrụgide dị ukwuu, ọ bụrụ na e mebiri iguzosi ike n'ezi ihe ya, ọ nwere ike gbaa 10 mita.

Ibu ahụ ụbụrụ mmadụ dị ihe dịka 2% nke mkpokọta ahụ, mana ọ na - eri ihe dị ka 20% nke oxygen na - abanye n'ọbara. Eziokwu a na-eme ka ụbụrụ mmadụ nwee ike ịkwụsi ike maka mmebi nke enweghị oxygen.

Dabere na ọmụmụ, ụmụ nwanyị ndị na-a severalụ ọtụtụ iko biya ma ọ bụ mmanya kwa izu nwere ihe ize ndụ ka ukwuu nke ịrịa kansa.

Onye ọ bụla nwere ọ bụghị naanị mkpụrụ aka dị iche, kamakwa asụsụ.

Nwa nwoke onye Australia dị afọ 74, James Harrison ghọrọ onye na-enye ọbara n'ihe dị ka 1,000 ugboro. O nwere ụdị ọbara dị ụkọ, ọgwụ mgbochi nke enyere ụmụ amụrụ ọhụrụ aka na-arịa oke anaemia. N'ihi ya, onye Australia chebere ihe ruru ụmụaka nde abụọ.

Afọ mmadụ na-arụ ọrụ dị mma site na iji ihe ndị si mba ọzọ na-enweghị ọgwụ. A maara na mmiri mkpụrụ osisi nwere ike igbari ọbụna mkpụrụ ego.

Ndị dọkịta ezé apụtawo n'oge na-adịbeghị anya. Laa azụ na narị afọ nke 19, ọ bụ ọrụ dịịrị onye na-edozi isi nkịtị iji wepụ ezé na-arịa ọrịa.

Imirikiti ụmụ nwanyị na-enwe ike inweta obi ụtọ karịa ịtụgharị uche n'ahụ ha nke ọma n'enyo karịa inwe mmekọahụ. Yabụ, ụmụ nwanyị, gbaa mbọ maka nkwekọrịta.

O buru na inyinya inyinya, ino karie igha olu gi karia ka inwere n’agha. Naanị anwala igosipụta nkwupụta a.

Emepụtara ọgwụ a maara nke ọma "Viagra" maka ọgwụgwọ nke ọbara mgbali elu.

Akụrụ anyị nwere ike sachapụ lita atọ nke ọbara n'otu nkeji.

Imeju bụ akwara kacha anyị n’ahụ. Ogo ya di 1.5 n'arọ.

N’inye nlele mgbe niile n’elu akwa anụ ahụ, ohere i nwere ibute ọrịa anụ ahụ na-abawanye site na 60%.

Caries bụ ọrịa na-efe efe a na-ahụkarị n'ụwa niile nke na-enweghị ike ịsọ mpi.

A na-emefu ihe karịrị nde $ 500 kwa afọ na ọgwụ ndị nwere nsogbu nfụkasị naanị na United States. Still kwenyere na a ga-achọpụta ụzọ iji merie allergies n'ikpeazụ?

A ma mmanụ azụ azụ kemgbe ọtụtụ iri afọ, n'oge a, egosiputala na ọ na - enyere aka belata mbufụt, belata nkwonkwo mgbu, na - emeziwanye sos.