Lisiprex - (Lisiprex)

Lysiprex bụ ọgwụ ezubere maka ọgwụgwọ nke ọrịa obi na akwara vaskụla. Nyere ike nke ikpe ahụ, a na-eji ya na ọgwụ ndị ọzọ ma ọ bụ dịka ngwa nnwere onwe. Iji nwee usoro akụrụngwa na-arụ ọrụ ọfụma na ọrịa na-adịghị ala ala, a na-enye ọgwụ ọgwụ maka nchịkwa prophylactic.

Omume ọgwụ

Agụnyere ọgwụ a na otu nke ACE inhibitors. Lisinopril na-ebelata ọrụ nke ACE (enzyme angiotensin-na-agbanwe). N'ihi nke a, a na-ebelata ọ̀da nke angiotensin nke ụdị nke mbụ ruo na nke abụọ, nke nwere mmetụta vasoconstrictive ma na-akpali mmepụta nke aldosterone site na cortex adrenal, belatara.

Ọgwụ na-ebelata nrụgide na obere arịa ọbara nke ngụgụ, na-amụba nguzogide olu olu. Ọ na - eme ka a na --akpo endothelium glomerular, ọrụ ndị ọ na - arụrụ na ndị ọrịa nwere hyperglycemia.

Ihe nọ n'ọrụ na-agbasa mgbidi akwara karịa karịa na-emetụta bed venous. Site n'iji ọgwụ ahụ ogologo oge, hypertrophy cardiac myocardial na-ebelata. Ngwá ọrụ ahụ nwere ike belata nsị nke mkpụrụedemede mkpụrụedemede nke aka ekpe, mee ka ọnọdụ ndị mmadụ butere nkụchi obi sie ike.

Mlọ ọgwụ

Theakingụ ọgwụ ahụ enweghị nri na nri. Usoro itinye aka na-agafe ruru 30% nke ihe ndị dị n'ọrụ. Bioavailability bụ 29%. Indmịnye ihe ndị na-edozi ọbara dị obere. N’agbanwe agbanwe, ihe bụ isi na ihe inyeaka na-abanye n’ọbara.

A na-ahụta ndọta kachasị na plasma n'ime awa 6. Fọrọ nke a esighi na usoro metabolic. A na - agbanwe ya site na mmamịrị na mmamịrị. Iwepu ọkara ndụ na-ewe awa 12.5.

Gịnị ka enyere ya?

Ihe ngosi maka ojiji nke lysiprex:

• ụdị mkpa hypotension akwara ozi,
• ọrịa shuga,
• ọrịa obi na-adịghị ala ala
• nnukwu myocardial infarction.

Na nnukwu nkụchi obi, a ga-a drugụ ọgwụ ahụ na ụbọchị mbụ mgbe ọgụ ahụ gbochiri mmerụ ahụ ventricle obi ekpe.

Ihe ngbanwe

Ọrịa nlekọta ọrịa na-amachi nchịkwa Lysiprex:

• hypersensitivity na otu akụkụ nke ọgwụ,
• ọnụnọ nke edebi Quincke na akụkọ banyere ezi na ụlọ,
• mkpụrụ ndụ ihe nketa na mmeghachi omume dị ka angioedema.

Ekwekọrịtara nke contraindication, na ọnụnọ nke eji ikike nke Lysiprex, ma jiri nlezianya na nlezianya na-atụle ọnọdụ onye ọrịa,

• mitral stenosis, aortic, akwara akwara,

• Cardiac ischemia
• mmepe nke hypotension akwara,
• oke nrụrụ akụrụ
• ọnụnọ nke ụba ịta potassium na ahụ,
• autoimmune connective anụ ahụ na-arịa.

Amachibidoro iji ọgwụ na ọgwụgwọ nke ọrịa obi na ndị ọrịa bụ ndị nnọchite agbụrụ ojii.

Etu esi ewere lisiprex?

Mbadamba nkume ndị ahụ na-ata ata na-ata ata, n'agbanyeghị nri. Nkezi onunu ogwu a na-atụ aro ka ọ bụrụ mgodi iri abụọ kwa ụbọchị, ego kachasị anabata kwa ụbọchị bụ 40 mg. A na-agbakọ oge ọgwụgwọ ọ bụla, ọ dabere n'ịdị ogo ọrịa ahụ na ogo mgbaàmà ya. Mmetụta ọgwụgwọ nke ị theụ ọgwụ ahụ na-apụta mgbe ụbọchị 14-30 gasịrị.

Usoro onunu ogwu maka monotherapy nke obi ike adighi ala: ogwu mbu - 2.5 mg kwa ubochi. Maka ụbọchị 3-5, mmụba gaa na 5-10 mg kwa ụbọchị ga-ekwe omume. Hapụrụ kachasị bụ 20 mg.

Usoro ọgwụgwọ mgbe usoro nkụchi obi gasịrị na 24 awa mbụ mgbe ọgụ ahụ gasịrị: 5 mg, kwa ụbọchị ka a na-emeghachi ọgwụ ahụ n'otu usoro onunu ogwu. Mgbe ụbọchị abụọ gachara, ịkwesịrị ị mgụ ọgwụ mg 10, na-esote ụbọchị, a na-amaliteghachi dose ahụ na usoro nke 10 mg. Ọgwụgwọ ahụ nwere ike ịdị izu anọ ruo izu isii.

Ọrịa mamịrị na-arịa ọrịa shuga - ihe ruru 10 mg kwa ụbọchị, n'ihe banyere nnukwu onyonyo egosipụtara, enwere ike ịbawanye usoro a ga-anabata karịa kwa ụbọchị 20 mg.

Leasedị mwepụta, nkwakọ ngwaahịa na ihe mejupụtara

Mbadamba nkume ndị ahụ dị ọcha, gburugburu, dị larịị, nwere bevel na notch.

Ndị pụrụ iche: calcium hydrogen phosphate anhydrous - 50 mg, mannitol - 20 mg, ọka ọka - 34.91 mg, talc - 3 mg, magnesium stearate - 1.2 mg.

10 PC - ngwugwu ọnya (3) - ngwugwu nke kaadiboodu.
30 PC - polymer Mkpọ (1) - ngwugwu nke kaadiboodu.

Ngosiputa ogwu

Ihe di nkpa na nnagide obara ohuru (dika nke monotherapy ma obu ya na ogwu ndi ozo).

Ọrịa obi na-adịghị ala ala (dịka akụkụ nke ọgwụgwọ njikọta).

Nnukwu myocardial infarction (n'ime awa iri abụọ na anọ izizi iji ọgwụ na -eche hemodynamic kwụsie ike iji nọgide na-egosipụta ihe ndị a ma gbochie divefunction ventricular ekpe na nkụda obi).

Nephropathy na-arịa ọrịa shuga (iji belata albuminuria na ndị ọrịa nwere ọrịa mellitus na-arịa insulin na-arịa ọrịa ọbara nkịtị na ndị ọrịa nwere ọrịa mellitus na-abụghị insulin na-arịa ọbara mgbali elu).

Mmetụta akụkụ

Site na usoro akwara obi: hypotension arterial, ihe mgbu n’azụ sternum kwere omume.

Site n'akụkụ nke usoro ụjọ ahụ: akpịrị, isi ọwụwa, ike ọgwụgwụ.

Site na usoro digestive: afọ ọsịsa, ọgbụgbọ, ọgbụgbọ.

Site na usoro iku ume: ụkwara akọrọ.

Site na usoro hemopoietic: agranulocytosis, mbelata hemoglobin na hematocrit (ọkachasị na iji ogologo oge), n'ọnọdụ ndị dịpụrụ adịpụ - mmụba na ESR.

N'akuku nke mmiri-electrolyte metabolism: hyperkalemia.

Metabolism: ụba creatinine, urea nitrogen (karịchaa ndị ọrịa nwere ọrịa akụrụ, ọrịa mellitus, ọbara mgbali elu).

Mmeghachi omume nfụkasị: ọnya anụ ahụ, angioedema.

Ndị ọzọ: n'ọnọdụ ndị dịpụrụ adịpụ - arthralgia.

Ntụziaka pụrụ iche

Ekwesighi iji Lisinopril mee ihe na ndị ọrịa nwere ọrịa aortic stenosis, obi akwara. Ejila ya na ndị ọrịa nwere nnukwu ọrịa myocardial infarction: na egwu dị oke nrụrụ ọria akwara metụtara ojiji nke vasodilator, yana arụ ọrụ ezumike.

Tupu na n'oge ọgwụgwọ, a ga-enyocha ọrụ akụrụ.

Tupu ịmalite ọgwụgwọ na lisinopril, ọ dị mkpa iji kwụọ ụgwọ maka ọnwụ nke mmiri na nnu.

Ejiri ha mee nlezianya pụrụ iche na ndị ọrịa nwere ọrụ akwara nwere nsogbu, yana akwara akwara stenosis, na nnukwu obi ọgbụgba.

Ohere ịmụba na-arịa ọbara ọgbụgba na-abawanye na mmụba mmiri n'ihi ọgwụgwọ ọrịa, nri nwere mmachi nnu, ọgbụgbọ, na ọgbụgbọ.

N'ime ndị ọrịa nwere nkụchi obi na ọbara mgbali dị ala ma ọ bụ belata ntakịrị, lisinopril nwere ike ịkpata hypotension art arịa siri ike.

A na-atụ aro ka iji lisinopril na-eme nri na-eme ka ọgwụ na-egbu nri, mgbakwunye nri maka nri na nnọchi nnu nwere potassium.

Site n'iji lisinopril na oge nke lithium, ekwesịrị ilebara ntinye lithium na plasma ọbara.

Mkparịta ụka ọgwụ ọjọọ

N'iji otu ihe eji eme ihe na antihypertensive ndị nnọchianya, enwere ike ịme ihe antihypertensive ịgbakwunye.

Site na iji ya eme ihe na-eme ka a na-egbu potassium (spironolactone, triamteren, amiloride), nkwado potassium, nnu nnu ndị nwere potassium, ihe ize ndụ nke hyperkalemia na-abawanye, ọkachasị ndị ọrịa nwere ọrụ mgbazinye nsogbu.

Site n'iji ACE inhibitors na NSAIDs n'otu oge, ihe egwu nke ịmalite nrụpụta akụrụ na-abawanye, hyperkalemia adịghị ahụkebe.

N'iji oge a na "akaghị" diuretics, thiazide diuretics, a na-eme ka mmetụta antihypertensive dịkwuo mma. Ọrịa hypotension akwara dị njọ, ọkachasị mgbe ị theụchara ọgwụ mbụ nke ọrịa diuretic, pụtara ihe pụtara na hypovolemia, nke na-eduga n'ọbara dị ntakịrị na mmetụta hyisensive nke lisinopril. Riskbawanye n'ihe egwu na arụ ọrụ na arụ ọrụ.

N'iji ya na indomethacin eme ihe, mmetụta antihypertensive nke lisinopril na-ebelata, o doro anya n'ihi mgbochi nke prostaglandin njikọ n'okpuru mmetụta nke NSAIDs (nke a kwenyere na ọ na-ekere òkè na mmepe nke mmetụta hypotensive nke ACE inhibitors).

N'iji insulin emeghari oge, ihe ndị na - eme hypoglycemic, ihe ndị na - eme ka sulfonylurea, hypoglycemia nwere ike ịmalite n'ihi mmụba glucose dị elu.

N'iji oge iji clozapine eme ihe, ntinye uche nke clozapine na plasma ọbara na-abawanye.

N'iji carbonate lithium mee ihe n'otu oge, itinye uche nke lithium na ọbara ọbara na-abawanye, tinyere ihe mgbaàmà nke ịhiụ mmanya lithium.

A kọwara okwu banyere mmepe nke hyperkalemia siri ike na onye ọrịa nwere ọrịa mellitus nke nwere otu oge iji lovastatin.

A kọwara okwu ikpe nke oke ọgbụgba ume na ojiji nke pergolide n'otu oge.

N'iji oge ethanol eme ihe, ethanol na-abawanye uto ethanol.

Ihe ngosi maka ojiji

Ekwesịrị iburu Lysiprex ma ọ bụrụ na ọnọdụ ndị a adị:

1. Ọbara mgbali akwara - dị mkpa na ntughari (ha abụọ bụ naanị ọgwụ ma jikọta ya na ọgwụ ndị ọzọ)
2. Ọrịa obi na-adịghị ala ala (dị ka akụkụ nke ọgwụgwọ njikọta)
3. Firstbọchị mbụ mgbe ọ rịasasịrị nnukwu ọrịa myocardial, yana ụdi sokwa na usoro njikọta ọgwụ
4. Ọrịa mamịrị nephropathy - iji belata albuminuria

Ofzọ nke ngwa

A na-atụ aro ị takeụ Lysiprex n'ụtụtụ otu ugboro n'ụbọchị. Ojiji nke ogwu a dabaghi ​​na ntinye nri.

A na-enye ndị ọrịa nwere ọbara mgbali elu nke na-anaghị a otherụ ọgwụ ndị ọzọ ka ọgwụ ha dị miligram 5 nke Lisiprex. Ọ bụrụ na enweghi mmetụta ọ bụla, a na -ekwu ọgwụ ahụ site na milligrams 5 kwa ụbọchị abụọ ruo ụbọchị atọ, ruo mgbe ha ruru 20-40 milligrams kwa ụbọchị.

Ọgwụ mmezi a na-eme kwa ụbọchị bụ milligram abụọ nke ọgwụ, ihe kachasị wee bụrụ 40. Mmetụta zuru oke na-abụkarị mgbe izu abụọ ruo anọ nke ọgwụgwọ gasịrị.

Maka ndị nwere nkụda mmụọ na-adịghị ala ala, ịmalite ọgwụ a bụ milligramms 2.5 kwa ụbọchị. Mgbe ụbọchị atọ ruo ise, a na-ahapụ ya ka ọ bụrụ ihe ruru milligram 5-10. Oke kachasị kwa ụbọchị bụ milligram abụọ.

Ọ bụrụ na onye ọrịa nwere nnukwu ọrịa myocardial infarction, a ga-enye ya milligrams nke Lysiprex n'ehihie, yana milligrams 5 ọzọ n'ụbọchị. N'ọdịnihu, ọ dị mkpa ị takeụ milligrams nke ọgwụ mgbe ụbọchị abụọ gasịrị na 10 ọzọ ka otu ụbọchị gachara. Ọgwụgwọ ya ji izu isii.

Site na nephropathy mamịrị, a na-atụ aro ka ọ were milligrams 10 nke ọgwụ kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ya na miligram 20.

Leasedị mwepụta, ihe mejupụtara

Ọgwụ a dị n’elu n'ụdị ndị a:

Ngwakọta nke Lysiprex gụnyere ihe ndị dị ka:

• 5, 10 ma ọ bụ 20 miligram nke lisinopril n'ụdị lisinopril dihydrate
• 40, 50 ma ọ bụ 100 milligram nke sọlfọ hydrogen phosphate
• 15, 20 ma ọ bụ 40 milligrams nke mannitol
• 34.91, 36.06 ma ọ bụ 69.83 milligrams nke ọka ọka
• 2,5, 3 ma ọ bụ 6 milligram nke talcum ntụ ntụ
• 1, 1.2 ma ọ bụ 2.4 milligram nke magnesium stearate.

Mmekọrịta na ọgwụ ndị ọzọ

Mgbe ị na-etinye Lysiprex, ọ dị mkpa iburu n'uche njirimara nke mmekọrịta ya na ọgwụ ndị ọzọ, nke a ga-akọwa n'okpuru:

1. Nchikota nke ogwu ahuru akuko na udiri nri nke potassium, ndi na –eme ka mmanu mmanu, ndi ozo edo edo, nke tinyere potassium na cyclosporine, na –eme ka ohere nke ibulite hyperkalemia ike.
2. Ojiji nke lysiprex na-eme ya na diuretics, beta-blockers, ngwa mgbochi calcium, antipsychotics, ọgwụ tricyclic antidepressants na ọgwụ mgbochi mkpali na-akwalite mmetụta antihypertensive.
3. Nchikota ya na ngwakọta nke lithium nwere ike ibute mmụba nke ihe a na ọbara
4. Nchikota nke lysiprex na ọgwụ hypoglycemic na-eme ka mmetụta ha dị elu ma nwee ike iduga mmepe nke hypoglycemia
5. Ọgwụ antisteroidal anti-inflammatory ọgwụ, estrogens, na agonergic agonists na-ebelata nsonso nke lisiprex. Na mgbakwunye, ijikọ ọnụ na ụdị ọgwụ mbụ nwere ike ibute ọrụ ezumike.
6. Inwe ojiji nke lysiprex ọzọ na serotonin reuptake inhibitors nwere ike ibute hyponatremia.
7. Njikọ ọgwụ a kọwara na ethanol na-akwalite mmetụta nke ndị ikpeazụ.
8. Nchikota nke lisiprex na procainamide, cytostatics na allopuripole nwere ike ibute leukopenia
9. Indomethacin belata mmetụta antihypertensive nke lisiprex
10. Mgbe ị na-etinye lysiprex na clozapine, itinye uche nke ikpeazụ na ọbara na-abawanye

E nwere ọtụtụ ọgwụ ọgwụ enweghị ike ịgụnye ya na lysiprex. Ndị a gụnyere:

Nsonaazụ

Ojiji nke lysiprex nwere ike ibute nsogbu ndị a:

1. Mgbu na sternum
2. Ike nsogbu adaa
3. Tachycardia
4. Bradycardia
5. Myocardial infarction
6. Ihe Nrịba ama nke Ọganiru Obi Nsogbu
7. Mmebi nke ụzọ agha
8. Dizziness
9. Isi ọwụwa
10. Paresthesia
11. Ikikere
12. Ọrịa Asthenic
13. Mmepo
14. Rowsjọ
15. Mgbaghoju anya
16. Agranulocytosis
17. Leukopenia
18. Neutropenia
19. Thrombocytopenia
20. Ọbara
21. Bronchospasm
22. Ntutu ume
23. Anorexia
24. Ọrịa mgbu
25. Ihe mgbu
26. Jaundice
27. Ọrịa ịba ọcha n'anya
28. Dyspepsia
29. Mgbanwe Ire
30. Ihicha mucosa onu
31. Ọsụsọ mụbara
32. Itching nke anụahụ
33. Urticaria
34. Alopecia
35. Photophobia
36. Oliguria
37. Anuria
38. Ọrịa akụrụ
39. Proteinuria
40. Mmekọ nwoke na nwanyị
41. Potassium gafere
42. Sodium ụkọ
43. Arthralgia
44. Myalgia
45. Ọrịa vasculitis
46. Ọrịa ogbu na nkwonkwo
47. Mmeghachi omume nfụkasị ahụ

Dodoụbiga ya ókè

Ọtụtụ mgbe, ihe mgbaàmà nke oke ịdoụbiga ọgwụ ókè nke Lysiprex na-apụta megide otu dose 50 grams nke ọgwụ. E gosiputara ha dika ndi a:

1. Ọnụ kpọrọ nkụ
2. Na mberede, nsogbu dara
3. Njide ure
4. Rowsjọ
5. Iwe
6. Ntachi
7. Nchekasị

Mgbe akara ndị dị otú ahụ pụtara, ọ dị mkpa ịgwọ ọrịa Symptomatic, ebe ọ bụ na enweghị ọgwụ mgbochi a kapịrị ọnụ. A na-eji afọ mee onye ọrịa ahụ ọrịa, nke enyere ya ọgwụ na laxatives. A na-edozi 0.9% sodium chloride intravenia.

A pụkwara ime ọgwụgwọ anụ ahụ. Okwesiri ijikwa ihe ngosi nke mmiri-electrolyte, yana obara mgbali.

N’oge ime ime

Notmụ nwanyị ndị na-achọ nwa ọhụrụ agaghị anabata Lisiprex. Ọ bụrụ na ime amalitela n’oge ọgwụgwọ a, ị ga-akwụsị ị itụ ya ngwa ngwa o kwere omume.

Ndi okacha amara egosila na iji ogwu a n’ime oge nke abuo na nke ato nwere mmetuta ojoo n’aru nwa ebu n’afọ, nke egosiputara na mbelata obara, mmepe nke akwara, oria cranial hypoplasia, hyperkalemia, na ọnwụ intrauterine.

Dika onwa mbu nke iteghete, onweghi ihe akaebe na –emebi ihe ojoo Lisiprex n’aru nwa ebu n’afọ. Mana ekwesiri icheta na ogwu a nwere ike banye n’ime Plasenta.

Usoro na ọnọdụ nchekwa

Chekwaa ọgwụ akọwapụtara na ebe kpọrọ nkụ, na-echebe ya site na ìhè anyanwụ na nke ụmụaka anaghị enweta ya. Ọnọdụ nchekwa nchekwa ekwesịghị gafere ogo 25 Celsius.

Ndụ nchekwa nke Lysiprex bụ afọ abụọ.

Ruo taa, Lysiprex adịghị na ụlọ ahịa ọgwụ nke Russian Federation.

Ugbu a, na ọgwụ ndị Ukraine, Lisiprex abụghị maka ọrịre.

N'ime ọgwụ ọgwụ ọgbara ọhụrụ, enwere ọtụtụ ọgwụ ọgwụ ndị yiri ihe ha na Lisiprex. Ndị a gụnyere ọgwụ ndị a:

Ruo taa, enwere nnwale ọ bụla na Lysiprex na ntanetị. Ma na njedebe nke ederede, ị nwere ike ịmata echiche nke ndị jiri ya maka ọgwụgwọ.

Ọ bụrụ na ị everụ ọgwụ a, biko gwa ndị ọzọ na - agụ akwụkwọ ka ị gwa gị ihe ịchọrọ.

Site n'akụkụ nke metabolism

Mmụba creatinine mụbara. N'ime ndị nwere ọrịa akụrụ na ọrịa shuga, urea nitrogen na-abawanye.

Oria akwara, mmepe nke anakpa.

Ọ bụ ihe na-adịghị mma iji nye ndị na-ahụ ọnya isi na isi ọwụwa mgbe ha na-ewere Lisiprex.

Jiri n'oge ime na lactation

Onwere ihe ojoo di na nwa ovu a, okachasi n’ime oge nke abuo n’abuo n’abuo. Nwanyị na-ewere mbadamba ọgwụ Lysiprex mgbe ọ mụtachara banyere afọ ime kwesịrị ịkwụsị ị .ụ ọgwụ. Onweghi ihe akaebe banyere enwere ike ihe ndi ogwu ahu di ngbo na ara ara. Mgbe ị na-a breastụ ara, a prohibitedachibidoro ị drugụ ọgwụ ahụ ike n'ihi ihe egwu ọ bụla nwere ike ịmetụta nwa ahụ.