Mbadamba ọgwụ Gliformin: ihe ngosi maka ojiji, mmetụta ndị ọzọ yana analogues nke ọgwụ

Ngwunye hypoglycemic nke sitere na ìgwè biguanide.
Nkwadebe: GLYFORMIN®
Ọrụ umi nke ogwu: metformin
Ihe nzuzo ATX: A10BA02
KFG: Ọgwụ ọgwụ hypoglycemic
Nọmba ndebanye: P Nke 003192/01
Bọchị ndebanye: 04/21/04
Ndi nwe reg. doc.: osisi na ọgwụ ọgwụ AKRIKHIN OJSC

Mwepụta wepụtara ya na ihe mejupụtara

Dodị usoro Gliformin bụ mbadamba.

Ihe dị n'ime ọgwụ ahụ bụ metformin hydrochloride. Ntinye uche ya n’otu mbadamba ụrọ nwere ike ịbụ 500 mg, 850 mg ma ọ bụ 1 gram.

Ihe ntinye aka nke mbadamba 500 mg bụ calcium phosphate dihydrate, sorbitol, povidone (polyvinylpyrrolidone), stearic acid ma ọ bụ steetite calcium, macrogol (polyethylene glycol). A na-ere mkpụrụ 60. na kaadiboodu (ngwugwu 6 nwere iko oyuyo nke nwere iko 10 n’ime ha).

Ihe ndị ọzọ Glyformin 850 mg na mbadamba gram 1 bụ stachi nduku, stearic acid, povidone (polyvinylpyrrolidone). Na usoro ọgwụ ndị a, a na-ere mbadamba 60. na Mkpọ polypropylene.

Mlọ ọgwụ

Metformin bụ ọgwụ ọgwụ hypoglycemic nke nwere ụdị biguanides. Ọ na -ebelata ngosipụta hyperglycemic, ma belata ihe ize ndụ nke hypoglycemia. N'adịghị ka usoro sulfonylurea, ihe ahụ anaghị akpali mmepụta nke insulin ma ọ nweghị mmetụta hypoglycemic mgbe ejiri ya na ndị ọrụ afọ ofufo nwere ahụ ike.

Metformin na --ekwupụta uche nke ndị na - anabata ihe na - eme insulin ma na - akwalite mgbatị glucose na sel, na - egbochikwa gluconeogenesis na imeju ma na - egbochi nnabata nke carbohydrates na eriri afọ. Metformin na - arụ ọrụ na - emepụta glycogen site na ịme ihe na glycogen synthase ma nwekwuo ikike ibufe n'ụdị ndị ọ bụla na - ebugharị glucose membrane.

Glyformin na-emetụtakwa metabolism lipid, belata ịta nke triglycerides, obere lipoproteins dị ala na cholesterol zuru oke. N'aka usoro ọgwụgwọ metformin si dị, ibu ahụ onye ọrịa na-agbanwe agbanwe ma ọ bụ na-ebelata obere oge.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, a na-etinye metformin na ngọngọ nri kpamkpam. Ndụ ya zuru oke ruru 50-60%. Oke ihe gbasara ihe dị na plasma erutela ihe ruru awa 2.5 mgbe nchịkwa ma ọ bụ 15 olmol, ma ọ bụ 2 /g / ml. Mgbe ị na-ewere metformin na nri, ịmịkọrọ ya na-ebelata ma belata. A na-ekesa ya ngwa ngwa n’akwara niile nke anụ ahụ, ọ fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe jikọrọ ya na protein protein.

Metformin bụ metabolized ntakịrị ntakịrị ma wepụta ya na mmamịrị. Nwepu ya n'ime ndị ọrụ afọ ofufo nwere ahụike bụ 400 ml / min (nke dị okpukpu 4 karịa nke ikike creatinine), nke na-egosi ọnụnọ nke tubular siri ike. Ọkara ọkara bụ ihe dịka 6.5 awa. Na ọdịda akụrụngwa, ọ na-abawanye, nke na-ebute ihe egwu nke ọgwụ ọgwụ.

Ihe ngosi maka ojiji

Edere Gliformin na ọgwụgwọ nke:

• oria di oria II, mgbe ọgwụ adịghị ike sulfonylureas nausoro ọgwụgwọ nri,
• ụdị m ọrịa shuga dị ka mgbakwunye na ọgwụ insulin.

Ihe ngbanwe

Ọ naghị atụ aro ị thisụ ọgwụ a na:

• ọrịa mamịrị na precomatous ọnọdụ
• ketoacidosis,
• ọrịa na-efe efe
• ọnya imeju na akụrụ
• cardiovascular or cardiopulmonary ọdịda,
• nnukwu myocardial infarction,
• lactation, ime ime.

Ntụziaka maka iji Gliformin (Usoro na usoro onunu ogwu)

Dịka ntuziaka maka iji Gliformin si kwuo, a na-ewere mbadamba mbadamba ihe. N'okwu a, ụbọchị 3 mbụ, a na-enye ndị ọrịa ọgwụ 500 mg ka mkpụrụ ọgwụ atọ n'otu ugboro n'ụbọchị, n'otu oge ma ọ bụ mgbe nri gasịrị. Mgbe ahụ usoro onunu ogwu na - abawanye rue 1 g. Ọtụtụ mgbe, usoro mmezi ahụ kwa ụbọchị bụ 0.1-0.2 g.

Dodoụbiga ya ókè

N'ọnọdụ ịdoụbiga mmanya ókè nwere ike ime lactic acidosisegbu egbu. Isi ihe kpatara mmepe ya bụ nchịkọta. metformin n'ihi ọrụ ezughi oke ọrụ. N'oge mbido ogbo na-egosi: ọgbụgbọ, vomiting, afọ ọsịsa, adighi ike, ahuhujuru afọ na ahu mgbu, mbelata nke ukwu, bradyarrhythmia. Mgbe ahụ ume ngwa ngwaanya ntugharionye nwere nsogbu na mmepe Coma.

Mgbe ihe ngosi pụtara lactic acidosis ikwusi ozugbo iwere Gliformin. A na-eme usoro ọgwụgwọ ọzọ n'ụlọ ọgwụ, yabụ onye ọrịa chọrọ ụlọ ọgwụ, na-eguzobe ịba ụba nke lactate, na-akwado nchoputa ya. Usoro dị irè ịba ọcha n'anyana - enyere aka wepu aru lactate na metformin. A na-emekwa usoro ọgwụgwọ ọzọ.

Releasedị mgbapụta Glyformin, nchịkọta ọgwụ na ihe mejupụtara.

Mbadamba dị ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ na-acha ọcha, cylindrical ewepụghị, na bevel na notch.

Taabụ 1
metformin (n'ụdị hydrochloride)
250 mg
-«-
500 mg

Ndị na-ahụ maka ya: sorbitol, calcium phosphate dihydrate, polyvinylpyrrolidone (povidone), polyethylene glycol (macrogol), stearate calcium ma ọ bụ stearic acid.

10 PC. - ngwugwu ọnya (3) - ngwugwu nke kaadiboodu.
10 PC. - ngwugwu mkpọ (6) - ngwugwu nke kaadiboodu.
10 PC. - ngwugwu ọnya (10) - ngwugwu nke kaadiboodu.
60 pcs. - Mkpọ nke iko gbara ọchịchịrị (1) - ngwugwu nke kaadiboodu.
100 pcs - Mkpọ nke iko gbara ọchịchịrị (1) - ngwugwu nke kaadiboodu.

NWAANYI NIILE ANYA.
A na-egosi ozi niile enyere naanị maka ịmara ọgwụ ahụ, ị ​​kwesịrị ịkpọtụrụ dọkịta maka ohere eji ya.

Ngwa ọgwụ nke glyformin

Onye na-ahụ maka hypoglycemic nke sitere na ìgwè nke biguanides (dimethylbiguanide). Usoro nke metformin na-ejikọta ya na ikike ya iji mee ka gluconeogenesis kwụsị, yana imepụta abụba na-enweghị ihe na nsị nke abụba. Metformin anaghị emetụta oke insulin n'ime ọbara, kama ọ na-agbanwe ọgwụ ọgwụ ya site na ibelata ogo insulin na-ejedebe ma na-abawanye oke nke insulin na proinsulin. Otu njikọ dị mkpa na usoro nke metformin bụ mkpali nke glucose na - eme ka mkpụrụ ndụ mepụta ya.

Metformin na - akwalite mgbasa ọbara n'ime imeju na-emekwa ka ntụgharị glucose na glycogen gbanwee. Belata ogo triglycerides, LDL, VLDL. Metformin na - eme ka akwara fibrinolytic dị n'ọbara site na - egbochi ihe mgbochi plasminogen onye na - eme ka anụ ahụ nwee ọrụ.

Usoro onunu ogwu na uzo icho ogwu a.

Maka ndị ọrịa anaghị anata insulin, n’ime ụbọchị atọ ndị mbụ - 500 mg ugboro atọ / ụbọchị ma ọ bụ 1 g ugboro abụọ / ụbọchị n’oge ma ọ bụ mgbe nri gasịrị. Site n'ụbọchị nke anọ ruo ụbọchị nke 14 - 1 g ugboro atọ / ụbọchị. Mgbe ụbọchị nke iri na ise gasịrị, a na-agbazi dose a na-eburu n'uche ogo glucose dị n'ọbara na mmamịrị. Usoro nlekọta ahụ bụ 100-200 mg / ụbọchị.

N'iji insulin emeghari onodu ya na oge erughi 40 nkeji / ubochi, usoro onunu ogwu nke metformin bu otu, ebe enwere ike wedata uzo insulin jiri nwayọ belata (site na nkeji 4-8 / ubochi ubochi obula). Ọ bụrụ na onye ọrịa ahụ na-enweta ihe karịrị nkeji iri anọ / ụbọchị, mgbe ahụ, ojiji nke metformin na mbelata nke insulin chọrọ nlekọta dị ukwuu ma eme ya n'ụlọ ọgwụ.

Mmetụta nke glyformin:

Site na usoro nri: enwere ike (ọ na-abụkarị mmalite nke ọgwụgwọ) ọgbụgbọ, ọgbụgbọ, afọ ọsịsa.

Site na usoro endocrine: hypoglycemia (tumadi mgbe ejiri ya na usoro ezughị ezu).

Site n'akụkụ nke metabolism: n'ọnọdụ ụfọdụ - lactic acidosis (chọrọ ịkwụsị ọgwụgwọ).

Site na usoro hemopoietic: n'ọnọdụ ụfọdụ - megaloblastic anaemia.

Ihe mgbochi ọgwụ:

Mmebi siri ike nke imeju na akụrụ, obi na akụkụ iku ume, oke akụkụ nke myocardial infarction, ahoụrụma na-egbu egbu, ọrịa shuga, ketoacidosis, lactic acidosis (gụnyere akụkọ ntolite), ọrịa mamịrị ụkwụ na-arịa ọrịa shuga, ịtụrụ ime, lactation, hyperensitivity to metformin.

NKWREKWỌ na mmechi
Contraindicated na ime na lactation.

Ntụziaka pụrụ iche maka ojiji nke glyformin.

A naghị akwado ya maka ọrịa na-efe efe, iwe ọkụ nke ọrịa na-efe efe na mkpali, mmerụ ahụ, ọrịa ịwa ahụ na-adịghị ala, na ihe ize ndụ nke akpịrị ịkpọ nkụ.

Ejila ya n’ihu ịwa ahụ yana n’ime ụbọchị 2 mgbe emechara ha.

A naghị atụ aro iji metformin na ndị ọrịa gafere afọ 60 na ndị na-arụ ọrụ anụ ahụ dị arọ, nke jikọtara ya na oke ihe ize ndụ nke ịmalite lactic acidosis.

N'oge ọgwụgwọ, ọ dị mkpa iji nyochaa ọrụ gbasara akụrụ, mkpebi nke lactate dị na plasma kwesịrị ịdịkarịa ala ugboro abụọ n’afọ, yana mpụta nke myalgia.

Enwere ike iji Metformin mee ihe na njikọta na sulfonylureas. N'okwu a, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose ọbara.

A na-atụ aro iji metformin dịka akụkụ nke njikọta ọgwụ na insulin n'ụlọ ọgwụ.

Mkparịta ụka Gliformin na ọgwụ ndị ọzọ.

Iji otu ihe eji eme ihe na usoro sulfonylurea, acarbose, insulin, salicylates, MAO inhibitors, oxytetracycline, ACE inhibitors, yana clofibrate, cyclophosphamide, hypoglycemic mmetụta nke metformin nwere ike ịbawanye elu.

Site na iji GCS eme ihe n'otu oge, mgbochi nke homonụ maka nchịkwa ọnụ, adrenaline, glucagon, homonụ thyroid, ihe ndị phenothiazine, thiazide diuretics, nicotinic acid, na mbelata mmetụta hypoglycemic nke metformin ga-ekwe omume.

Iji cimetidine na-ejikọ ọnụ nwere ike ịbawanye ohere nke lactic acidosis.

Ntuziaka maka iji Gliformin: usoro na usoro onunu ogwu

A na-ewere mbadamba Glyformin n'ọnụ n'oge nri ma ọ bụ ozugbo, na-adịghị ata ata, yana ọtụtụ mmiri.

Dọkịta depụtara etu a ga-esi hazie ya na oge nchịkwa n’otu n’otu, na-eburu n’uche ogo mgbanye glucose na ọbara.

Na mmalite ọgwụgwọ, ụbọchị 10-15 mbụ, ọnụọgụ ahụ nwere ike ịbụ 0,5 ruo 1 g otu ugboro n'ụbọchị, mgbe ahụ, dabere na ọkwa shuga dị n'ọbara, enwere ike ịbawanye nwayọ. Usoro nlekọta ahụ, dị ka iwu, bụ 1.5-2 g kwa ụbọchị, kewara n'ime usoro 2-3.

Oke kachasị maka Gliformin kwa ụbọchị bụ 3 g.

Maka ndị ọrịa agadi, ọnụ ọgụgụ kachasị maka ọgwụ a na-anabata bụ 1 g kwa ụbọchị.

N'ọnọdụ nsogbu metabolic dị mkpa, a na-atụ aro ka a belata ọgwụ ahụ, ebe ọ bụ na ihe ize ndụ nke lactic acidosis na-abawanye.

Nsonaazụ

• Site na usoro endocrine: ọ bụrụ na ị doụbiga ya ókè - hypoglycemia,
• Site na usoro nri: enweghị agụụ, afọ na-egbu mgbu, ọgbụgbọ, ụtọ ọla na ọnụ, afọ ọsịsa, ọgbụgbọ, ekpomoku (mgbaàmà ndị a bụ njirimara maka ịmalite ọgwụgwọ, mgbe ahụ ọnọdụ ahụ na-aga n'ihu),
• Site na usoro hemopoietic: oge ​​ụfọdụ - megaloblastic anaemia,
• Site n'akụkụ nke metabolism: na ọgwụgwọ ogologo oge - hypovitaminosis B₁₂, na mgbe ụfọdụ, lactic acidosis,
• Mmeghachi omume nfụkasị ahụ: ọnya anụ ahụ.

Ọ bụrụ na nsonaazụ na-apụta, ọ dị mkpa ịkagbu Glyformin nwa oge ma kpọtụrụ dọkịta.

Ntụziaka pụrụ iche

Ekwesịrị ịgụnye usoro ọgwụgwọ yana ịgachi ọkwa nke glucose ọbara.

N'oge ọgwụgwọ, ekwesịrị ịme ọmụmụ ihe kwa ọnwa isii iji chọpụta ọkwa nke lactate na creatinine na plasma ọbara. A na-enyocha nlezianya ọrụ akụrụ n’ime ndị ọrịa agadi. Ekwesighi inye ndi nwoke nwere oke okike ihe dị elu nke 135 μmol / L, Glyformin nwere ya - 110 μmol / L.

Enwere ike belata mmetụta ndị sitere na sistemụ nri site na iji ọgwụ mgbochi ma ọ bụ ọgwụ antispasmodics n'otu oge.

N'oge ọgwụgwọ kwesịrị izere ị alcoholụ mmanya na ngwaahịa nwere ethanol.

Site na monotherapy, Gliformin anaghị emetụta ikike iji ụgbọ ala na-arụ ọrụ na usoro.

Mgbe ị na-ewere Gliformin na ndị ọrụ hypoglycemic ndị ọzọ, gụnyere insulin, sulfonylureas, ọ dị mkpa ịkpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe omume dị ize ndụ nke chọrọ oke ọsọ nke nzaghachi psychomotor na nlebara anya.

Ime na lactation

Ejiri usoro metformin n'oge ime na inye nwa ara.

Mgbe ị na-eme atụmatụ ịtụrụ ime, yana ọ bụrụ na ọ mere n'oge ọgwụgwọ Gliformin, a na-akagbu ọgwụ ahụ wee depụta ọgwụ insulin.

Emebebeghị ya n'ụzọ ziri ezi ma metformin na-abanye na mmiri ara ara, yabụ ekwesighi ịkọwa Glyformin n'oge a na-enye ya ara. Ọ bụrụ na oriri ya dị oke mkpa, a ga-akwụsị inye ya ara.

Mkparịta ụka ọgwụ ọjọọ

Ọ ga-ekwe omume ịkwalite ọrụ nke Glyformin na iji otu oge na insulin, beta-blockers, sulfonylureas, ọgwụ mgbochi na-abụghị steroidal, acarbose, monoamine oxidase inhibitors, angiotensin na-agbanwe ndị na-egbochi enzyme, oxytetracycline, cyclophosphamide, na ndị ọzọ.

Enwere ike belata utịp Gliformin mgbe ị na-eji glucagon, glucocorticosteroids, mgbochi mkpị ọnụ, homonụ thyroid, epinephrine, ọmịiko, "akaghị" na thiazide diuretics, usoro nicotinic acid na phenothiazine.

Ojiji nke ndị na-ejikọ ethanol nwere ike ime ka mmepe nke lactic acidosis.

Kpochapu Glyformin na-agbadata mgbe ejiri ya na cimetidine, ohere nke ịmalite lactic acidosis na-abawanye.

Site na nhazi oge a na anticoagulants, ọgwụ coumarin, a na-ebelata mmetụta ha.

Analogues nke Gliformin bụ: Glucofage, Glucofage Long, Glukoran, Gliguanid, Dformin, Diaberit, Diabetosan, Diabexil, Diguanil, Metformin, Melbin, Mellitin, Metiguanid, Modulan, Formmetin.

Nyocha banyere Gliformin

Dabere na nyocha nke Gliformin, ọ dị irè ma n'ihe banyere ọrịa shuga mellitus na ọrịa metabolic dị iche iche. Ọzọkwa, ndị ọrịa na-achọkarị ifelata, ụfọdụ ndị na-ejikwa ya maka ebumnuche ndị a na-ekwu na ha nwere ike tufuo ike ma hazie ọkwa hormonal nke ọma. Agbanyeghị, ọtụtụ ndị ọkachamara na-adọ aka na ntị megide iji Gliformin maka ịbelata ibu, ma ọ bụrụ na enweghị njiri ike doro anya maka nke a.

Patientsfọdụ ndị ọrịa na-ekwupụta mmetụta ọjọọ ọgwụ ọjọọ na-adịghị mma, gụnyere isi ọwụwa, adịghị ike, diski diski. Ebe ọ bụ na ọ nwere ike imebi ahụike na mmetụta ọjọọ n'ahụ ahụ, a na-atụ aro ka ọ gaa usoro ọgwụgwọ kpam kpam n'okpuru nlekọta dọkịta.

Ọnụahịa nke Gliformin na ụlọ ahịa ọgwụ

Ọnụ ego dị ka mbadamba ihe ndị dị na Gliformin 0,5 g na ụdọ ahịa bụ 86-130 rubles (ngwugwu nwere mbadamba 60). Nwere ike ịzụta mbadamba na fim iji ihe omimi nke 0.85 g maka ihe dị ka 191-217 rubles, yana usoro 1 g maka 242-329 rubles (ngwugwu nke ọ bụla nwere mbadamba 60).

Gliformin: ọnụ ahịa na ụlọ ahịa ọgwụ dị n'ịntanetị

GLYFORMIN 500mg 60 PC. mbadamba ihe mkpuchi

Mpempe akwụkwọ mkpuchi gbara ndụ 0,85 g ihe nkiri 60 pcs.

Mmụta: Mahadum Ahụike Rostov State, ọpụrụiche "General Medicine".

A na - emejupụta ozi gbasara ọgwụ ahụ, enyere ya aka ka ọ nweta ihe ọ bụla, ọ naghị edochi ntuziaka gọọmentị. Medication medicationụ onwe gị ọgwụ dị ize ndụ nye ahụ ike!

Dabere na ọmụmụ, ụmụ nwanyị ndị na-a severalụ ọtụtụ iko biya ma ọ bụ mmanya n'izu, ha nwere ohere dị ukwuu nke ịrịa ọrịa cancer ara.

Dabere na ọtụtụ ndị ọkà mmụta sayensị, usoro ihe ọmụmụ vitamin abaghị uru ụmụ mmadụ.

Iji mee ka onye ọrịa pụọ, ndị dọkịta na-agakarị ngabiga. Dịka ọmụmaatụ, ụfọdụ Charles Jensen na oge site na 1954 ruo 1994. lanarịrị ihe karịrị 900 neoplasm n'ọrụ mwepụ.

N'oge ndụ, nkezi onye na-amịpụta obere mmiri mmiri abụọ.

Mpekere chọkọleti anọ gbara ọchịchịrị nwere ihe dị ka calorie narị abụọ. Yabụ ọ bụrụ na ịchọghị ịka mma, ọ ka mma ịghara iri karịa lobules abụọ kwa ụbọchị.

Dabere na ọnụ ọgụgụ, na ụbọchị Mọnde, ihe ize ndụ nke mmerụ azụ na-abawanye site na 25%, yana ihe ọghọm nke nkụchi obi - site na 33%. Kpachara anya.

Na mgbakwunye na ndị mmadụ, naanị otu ihe dị ndụ na mbara ụwa - nkịta, na-arịa ọrịa prostatitis. Ndị a bụ ndị enyi anyị kacha kwesị ntụkwasị obi.

Ọtụtụ nde nje na-amụ, na-ebi ma na-anwụ na anyị gootu. Enwere ike ịhụ ha naanị na nnukwu ịdị elu, ma ọ bụrụ na ha gbakọtara ọnụ, ha ga-adaba na iko kọfị mgbe niile.

Ndị ọkà mmụta sayensị America mere nyocha na ụmụ oke wee kwubie na mmiri mmiri mmiri na-egbochi mmepe nke atherosclerosis nke arịa ọbara. Otu ìgwè na -a mụ mmiri dị ọcha, nke abụọ abụrụ mmiri ọ aụ juiceụ. N'ihi nke a, arịa nke ndị otu nke abụọ enwere nnukwu palesterol.

Mgbe ndị hụrụ na-susuru ọnụ, nke ọ bụla n'ime ha na-efunahụ 6.4 kcal kwa nkeji, mana n'otu oge ahụ ha na-agbanweta ihe fọrọ nke nta ka ọ bụrụ ụdị 300 nke nje dị iche iche.

Ndị mmadụ na-eri nri ụtụtụ mgbe niile yikarịrị ka hà buru oke ibu.

Ọbara mmadụ "na-agabiga" n'ime arịa ndị nọ n'okpuru nrụgide dị ukwuu, ọ bụrụ na e mebiri iguzosi ike n'ezi ihe ya, ọ nwere ike gbaa 10 mita.

Nkezi afọ nke lefties erughị righties.

Na UK, enwere iwu dịka onye dọkịta na-awa ahụ nwere ike jụ ịrụ onye ọrịa ahụ ma ọ heụọ anwụrụ ma ọ bụ buru oke ibu. Mmadụ kwesịrị ịhapụ omume ọjọọ, mgbe ahụ, ikekwe, ọgwụgwọ ịwa ahụ agaghị achọ ya.

Ibu ahụ ụbụrụ mmadụ dị ihe dịka 2% nke mkpokọta ahụ, mana ọ na - eri ihe dị ka 20% nke oxygen na - abanye n'ọbara. Eziokwu a na-eme ka ụbụrụ mmadụ nwee ike ịkwụsi ike maka mmebi nke enweghị oxygen.

A ma mmanụ azụ azụ kemgbe ọtụtụ iri afọ, n'oge a, egosipụtagoro na ọ na - enyere aka belata mbufụt, belata nkwonkwo mgbu, na - emeziwanye sos.

Usoro onunu ogwu na ochichi nke Gliformin

Dịka iwu, dọkịta na-edobe usoro nke Glyformin n’otu n’otu, dabere n’ọkwa glucose dị n’ọbara.

Ọgwụgwọ na-amalitekarị site na iji 0,5-1 g kwa ụbọchị. Dabere na ọkwa nke glycemia, dose ahụ nwere ike ịmalite ịbawanye mgbe ụbọchị 10-15 gachara.

Usoro nlekọta kwa ụbọchị bụ 1-2 mbadamba nkume nke Gliformin 1000, nke a na-atụ aro ka e kewaa ya n'ọtụtụ usoro, nke nwere ike belata ogo mmetụta ndị ọ na-akpata na oke iwe.

Oke kachasị anabata kwa ụbọchị bụ mbadamba 3 nke Gliformin 1000, agbanyeghị, a na-atụ aro ka ndị agadi ghara ị noụ ihe karịrị 1 g nke ọgwụ.

Site na mmụba nke Gliformin, lactic acidosis nwere ike ịmalite site na nsonaazụ na-egbu egbu, mmalite nke ihe ndị ahụ bụ ọgbụgbọ, obere ahụ ahụ, adịghị ike, afọ ọsịsa, mgbu na afọ na akwara, bradyarrhythmia, mbelata ọbara mgbali, nkụda mmụọ, nsụda mmụọ, iku ume na mmepe nke coma. .

Usoro na ọnọdụ nchekwa

Gliformin bụ ọtụtụ ọgwụ ọgwụ hypoglycemic (ndepụta B) na ndụ nchekwa a tụrụ aro n'okpuru ọnọdụ nchekwa (na okpomọkụ ruo 25 Celsius):

• Na ọdịnaya nke 250 mg na 500 mg nke ihe na - arụ ọrụ - afọ 3,
• Na ọdịnaya nke 850 mg na 1000 mg nke ihe na - arụ ọrụ - afọ 2.

Ntuziaka maka mbadamba mbadamba

Ihe ngosiputa maka iji ogwu a bu oria oria oria mamiri 2, mgbe nri siri ike na ogwu ndi mmadu n’enyeghi nsogbu. Edere Glyformin maka ụdị ọrịa shuga 1 dị ka mgbakwunye inje insulin.

N'ime oge a na-eme ọgwụgwọ, a ga-enyocha arụ ọrụ akụrụ, ọ dịkarịa ala ọnwa isii ọ bụla ka akwadoro ka nyochaa nyocha iji chọpụta lactate na plasma ọbara.

Mbadamba ahụ nwere ike ị drunkụbiga mmanya ókè n'oge nri ma ọ bụ mgbe nri gachara, dọkịta kwesịrị ịgụta ya otu usoro ị doụ ọgwụ ọ individụ individụ kwesịrị, ichebara nsonaazụ ule shuga ọbara:

• na nmalite ọgwụgwọ, ọgwụ a karịrị ya bụ 1 gram kwa ụbọchị,
• mgbe ụbọchị iri na ise gasịrị, ọnụ ọgụgụ ego na-abawanye.

Ọkwa usoro ọgwụgwọ ọkọlọtọ ekwesịghị ịkarị gram 2 kwa ụbọchị, a ga-ekesasịrịrị ya n'ọtụtụ usoro. Ndị na-arịa ọrịa shuga dị afọ iri na ụma na-atụ aro ịkarị ọgwụ gram 1 nke ọgwụ.

Ọ bụrụ na dọkịta depụta Gliformin maka ọrịa shuga, onye ọrịa ahụ kwesịrị ịma na mbadamba ụrọ nwere ike ibute ọtụtụ mmeghachi omume na-adịghị mma nke ahụ. N'akụkụ nke usoro endocrine, hypoglycemia na-amalite, n'akụkụ ọbara ekesa, anaemia ga-ekwe omume, n'akụkụ nke ụkọ vitamin metabolism na-adị. Mgbe ụfọdụ, anụ ahụ na-azaghachi ọgwụ ọgwụ nwere mmeghachi omume nfụkasị:

Site na akụkụ nke eriri afọ bụ imebi agụụ, afọ ọsịsa, vomiting, ụtọ dị n’ọnụ.

Ọ bụrụ na mmeghachi omume ọ bụla na-akpata, ọ na-egosi na ọ jụrụ ọgwụgwọ na Gliformin, gakwuru dọkịta.

Ogwu Glyformin (ntuziaka ya dị na ntanetị) enwere ike iji ya maka ọdịda akụrụngwa na-agafeghị oke, mana ọ bụ naanị na enweghị ohere nke mmụba nke lactic acidosis. N'okwu a, a na-enyocha ọrụ akụrụ mgbe niile (ọbụlagodi otu ugboro n’ime ọnwa 3-6), mgbe iwepụsị creatinine na-agbadata n’ogo nke 45 ml / min, a na-akwụsị ọgwụgwọ ozugbo.

Ọ bụrụ na mbelata ọrụ ọrụ akụrụ na ọrịa shuga dị elu, usoro ọgwụgwọ nke metformin kwesịrị ka ọ gbanwee.

Contraindications, mmekorita ọgwụ

Ekwesighi inye ogwu Gliformin maka ketoacidosis, ọrịa imeju na-adịghị ala ala, ọrịa shuga, obi, ọdịda akwara, n'oge ime, inye nwa, myocardial infarction, oke mmetụta nke akụkụ ọgwụ ahụ.

Jiri nlezianya were ọgwụgwọ maka ọrịa etiology na-efe efe, tupu ịmalite ọgwụgwọ ịwa ahụ dị egwu.

Ofgwọ ọgwụ dị nfe nwere ike ibelata ọgwụgwọ ọgwụgwọ:

• ọgwụ glucocorticosteroid
• homonụ thyroid
• diuretics
• nicotinic acid
• mgbe ị na-a oụ ọgwụ mgbochi ọnụ.

Ọ bụrụ na ejiri metformin mee ihe na insulin, ọgwụ sulfonylurea, ọgwụ mgbochi mkpali na-abụghị steroidal, yana ndị na-egbochi beta, enwere ohere nke mmụba na nsonaazụ ya.

Gliformin Prolong

N'ọnọdụ ụfọdụ, onye ọrịa na-arịa ọrịa shuga na-egosi Gliformin ogologo oge - Gliformin ogologo. Ejiri ọnụ mmiri jupụta ya. Ngwá ọrụ nwere ike inye aka n'onwe ya ma ọ bụ bụrụ akụkụ nke ọgwụgwọ njikọta.

Ọ bụrụ na ndị nwere ọrịa shuga ewereghị metformin na mbụ, a na-atụ aro ya ka ọ bụrụ ọgwụ mbụ ka 750 mg otu ugboro n'ụbọchị. Mgbe izu abụọ gachara, dọkịta ahụ ga-ahazi usoro onyonyo (were 2 mbadamba 750 mg), dabere na nsonaazụ nke shuga. Site na mmụba ngwa ngwa na ọgwụ ahụ, enwere mbelata nke mmeghachi omume na-adịghị mma site na usoro nri, ọkachasị, ọrịa shuga na-apụ n'anya.

Mgbe usoro a tụrụ aro anaghị enweta iji nweta nchịkwa nkịtị nke ọkwa glycemia, ọ dị mkpa ị takeụ ọgwụ kachasị elu - 3 mbadamba 750 mg Ogologo oge kwa ụbọchị.

Ndị ọrịa mamịrị na-ewere metformin n'ụdị ọgwụ ịhapụ ahapụ oge niile:

1. ụọnụ oge ị anụ ya,
2. ọ bụrụ na ha na-a takeụ ihe karịrị 2000 mg, edeghị usoro maka ọgwụ ogologo oge.

Iji nweta njikwa glycemic kachasị, a na-eji metformin na insulin homonụ dị ka ọgwụgwọ njikọta. Buru ụzọ, standardụọ ọgwụ dị larịị (1 mbadamba 750 mg) n'oge nri abalị, a ga-ahọrọkwa insulin n'otu n'otu, dabere na shuga ọbara.

Oke kachasị kwa ụbọchị, enwere ike ịghara ịfe ihe karịrị 2250 mg ọgwụ ahụ, nyocha ndị dọkịta na-egosi na, ọ bụrụhaala na ahụ na-achịkwa nke ọma, ọ ga-ekwe omume ịgbanwee n ’ị theụ ọgwụ ahụ na ntọhapụ mbụ nke metformin na usoro nke 3000 mg.

Ọ na - eme na onye ọrịa ahụfuru ị theụ ọgwụ ahụ, nke gosipụtara na ọ ga - ewere mbadamba ọgwụ ọzọ na - esote ọgwụ n'oge ọ bụla. Nweghị ike ị takeụ okpukpu abụọ nke metformin, nke a ga - eme ka mmepe nke mmeghachi omume ndị na - adịghị mma n'akụkụ, na - eme ka ihe mgbaàmà nke shuga ghara ịka njọ.

Ekwesịrị ịbanye Glyformin Prolong kwa ụbọchị, na-ezere izu ike.

Onye ọrịa ahụ kwesịrị ịgwa dọkịta na-aga ya banyere njedebe nke ọgwụgwọ, chọpụta echiche ya.

Analogs, nyocha nke ndị dọkịta

N'ihi ọnụnọ nke contraindications, ọgwụ ahụ adịghị mma maka ọtụtụ ndị ọrịa, n'ọnọdụ a enwere mkpa ịhọrọ analogues nke ọgwụ ahụ, ha nwekwara ọnụ ọgụgụ dị iche nke ihe na-arụ ọrụ (250, 500, 850, 1000). Gliformin nwere ike ị aụ ọgwụ ike:

Ndị ọrịa shuga amatala ọgwụgwọ Gliformin na-egosi na ị ga-a anụbiga mmanya ókè. N'ọtụtụ oge, nke a bụ n'ihi iji ọgwụ ọjọọ eme ihe.

Do overụbiga mmanya ókè nwere ike ime ka mmepe nke ụdị ọrịa a dịka lactic acidosis. Isi ngosipụta ya: mgbu mgbu, ọgbụgbọ, ọgbụgbọ, mmụọ adịghị emetụta. Mgbe ụdị ọrịa ahụ pụtara, a na-atụ aro ịkwụsị ị .ụ ọgwụ.

Ndị dọkịta na-ekwu na ọgwụ Gliformin na-anagide ọrịa shuga n'ụzọ gara nke ọma, ma ọ bụrụhaala na a na-ahụ usoro ndị a tụrụ aro ya nke ọma. Ọzọ nke ọgwụ bụ ọnụ ahịa ezi uche dị na nnweta na pharmacies.

Endocrinologists na-adọ aka na ntị na oge usoro ọgwụgwọ, a chọrọ usoro nyocha maka serum creatinine. Ọgwụ a agaghị emekọtakọta Glyformin maka ọrịa shuga:

1. tinyere ihe ọholicụholicụ na-aba n'anya,
2. ọgwụ nwere ethanol.

Ọ bụ ihe nwute, ọrịa shuga abụrụla ọrịa a na-ahụkarị, yana n'etiti ndị na-eto eto. Maka ọgwụgwọ, ọ dị mkpa ịkọ ọgwụ na-enyere aka ịme ka ọkwa glycemia dị ka otu, otu n'ime ọgwụ ndị a bụ Gliformin. Ọ bụrụ na a na-agbaso ntuziaka maka ojiji nke ọma, nsonaazụ nke ọgwụ ahụ na-apụta na obere oge.

Enyere ozi banyere ọgwụ ịbelata shuga na vidiyo dị n'isiokwu a.

Usoro na ọnọdụ nchekwa

Gliformin bụ ọgwụ edenye ọgwụ.

Ekwesiri ịchekwa ya n’ebe nkụ, enweghi ike ịbanye na ìhè anyanwụ, na okpomọkụ nke ruru 25 ºС. Na nchekwa dị mma, ndụ nchekwa nke mbadamba 500 mg bụ afọ 3, mbadamba 850 mg na 1 gram - 2 afọ.

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