Ihe ngosi maka ojiji na ntuziaka maka ojiji nke ọgwụ Formetin

Ọgwụ hypoglycemic ọgwụ sitere na ìgwè biguanide.
Nkwadebe: FORMETIN®
Ọrụ umi nke ogwu: metformin
Ihe nzuzo ATX: A10BA02
KFG: Ọgwụ ọgwụ hypoglycemic
Nọmba ndebanye: LSR-003304/07
Ofbọchị idebanye aha: 10.22.07
Ndi nwe reg. doc.: FARMSTANDART-LEXREDSTVA OJSC

Mwepụta, Mpempe ọgwụ na ihe mejupụtara.

Mbadamba nkume ndị ahụ na-acha ọcha, gburugburu, ewepụghị-cylindrical na bevel na notch.

Taabụ 1
metformin hydrochloride
500 mg
-«-
850 mg

Ndị na-ahụ maka ihe: povidone kilogram na-ebu ibu (polyvinylpyrrolidone), sodium croscarmellose, magnesium stearate.

10 PC. - ngwugwu ọnya (3) - ngwugwu nke kaadiboodu.
10 PC. - ngwugwu mkpọ (6) - ngwugwu nke kaadiboodu.
10 PC. - ngwugwu ọnya (10) - ngwugwu nke kaadiboodu.

Mbadamba nkume ndị ahụ bụ ọcha, oval, biconvex, nwee mkpọchi na akụkụ abụọ ahụ.

Taabụ 1
metformin hydrochloride
1 g

Ndị na-ahụ maka ihe: povidone kilogram na-ebu ibu (polyvinylpyrrolidone), sodium croscarmellose, magnesium stearate.

10 PC. - ngwugwu ọnya (3) - ngwugwu nke kaadiboodu.
10 PC. - ngwugwu mkpọ (6) - ngwugwu nke kaadiboodu.
10 PC. - ngwugwu ọnya (10) - ngwugwu nke kaadiboodu.

Nkọwa ọgwụ a sitere na ntuziaka masịrị iwu maka iji ya eme ihe.

Eme ihe nke ogwu nke formin

Ọgwụ hypoglycemic ọgwụ sitere na ìgwè biguanide. Ọ na - egbochi gluconeogenesis na imeju, na - ebelata nnabata nke glucose na eriri afọ, na - eme ka ojiji nke glucose na - emeju kwa oge, na - emekwa ka ọ nwee ọgụgụ isi nke insulin. Ọ naghị emetụta nzuzo nke insulin site na mkpụrụ ndụ pancreatic, anaghị akpata mmeghachi omume hypoglycemic.

Lowers triglycerides, LDL.

Na-eme ka ahụ gị dị ike ma ọ bụ belata ya.

O nwere mmetụta nke fibrinolytic n'ihi mkpochapụ nke plasminogen activates inhibitor anụ ahụ.

Pharmacokinetics nke ọgwụ.

Mgbe nchịkwa ọnụ gasịrị, a na-etinye metformin na ngọngọ nri. Bioavailability mgbe ị nwesịrị ọkọlọtọ bụ 50-60%. A na-enweta Cmax mgbe nchịkwa ọnụ gachara awa 2.5.

Ọ fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Ọ na-agbakọ na gland ndị nwere akpụ, akwara, imeju na akụrụ.

A na - agbanwe ya na mmamịrị. T1 / 2 bụ awa 1.5-4.5.

Usoro onunu ogwu na uzo icho ogwu a.

Tọọ iche, ichebara ọkwa glucose dị n’ọbara.

Ọgwụ mbụ kwa ụbọchị na-abụkarị 500 mg 1-2 ugboro / ụbọchị ma ọ bụ 850 mg 1 oge / ụbọchị. Na-esote, jiri nwayọ (oge 1 kwa izu), a na-abawanye ọgwụ ahụ ruo 2-3 g / ụbọchị. Oke kachasị kwa ụbọchị bụ 3 g.

A na-atụ aro ka a na-atụ aro kwa ụbọchị karịrị 850 mg na usoro abụọ (ụtụtụ na mgbede).

N'ime ndị ọrịa merela agadi, ọgwụ kwa ụbọchị ekwesịghị gafere 1 g.

N'ihi oke ụba nke lactic acidosis, mgbe ị na-eduzi metformin na ndị ọrịa nwere nnukwu metabolism, a ga-ebelata dose ahụ.

E kwesịrị ibute mbadamba n'oge nri ma ọ bụ mgbe dum, yana ọtụtụ mmiri.

A na-ezube ọgwụ a maka iji ogologo oge.

Mmetụta akụkụ nke formin:

Site na nri digestive: ọgbụgbọ, ọgbụgbọ, ụtọ otite n'ọnụ, enweghị agụụ, afọ ọsịsa, ọnya afọ, mgbu afọ.

N'akụkụ nke metabolism: adịkarịghị - lactic acidosis (chọrọ ịkwụsị ọgwụgwọ), na iji ogologo oge - B12 hypovitaminosis (malabsorption).

Site na usoro hemopoietic: n'ọnọdụ ụfọdụ - megaloblastic anaemia.

Site na usoro endocrine: hypoglycemia (mgbe eji ya na usoro ezughị ezu).

Mmeghachi omume nfụkasị ahụ: ọnya anụ ahụ.

Ihe mgbochi ọgwụ:

- mamịrị ketoacidosis, ọrịa mamịrị, prema, shuga,

- Nsogbu oke gbasara akụrụ,

- arụ ọrụ imeju.

nsi a alcoholụ mmanya na - egbu egbu,

- ọnọdụ ndị nwere ike itinye aka na mmepe nke lactic acidosis, gụnyere Ọkpụkpụ obi na iku ume, nnukwu oge nke infarction myocardial, nnukwu ihe mberede ụbụrụ, akpịrị ịkpọ nkụ, mmanya na-egbu egbu,

- lactic acidosis na akụkọ banyere ya,

- ezigbo arụ ọrụ ịwa ahụ na mmerụ ahụ (n'ọnọdụ ndị a, egosi insulin ọgwụ),

- jiri ya mee ihe n’ime ụbọchi abụọ tupu ụbọchị abụọ ka emechara ọmụmụ redioisotope ma ọ bụ x-ray na ntinye nke ayodiin nwere ọdịiche,

- esoro na nri kalori (erughi 1000 cal / day),

- lactation (inye ara),

- Hypersensitivity na mmiri nke ọgwụ.

A naghị atụ aro ka iji ọgwụ ahụ mee ihe na ndị ọrịa gaferela afọ 60 ndị na-arụ ọrụ anụ ahụ dị arọ, n'ihi oke ụba nke lactic acidosis.

Ntụziaka pụrụ iche maka ojiji nke inmin.

N'ime oge iji ọgwụ ahụ, a ga-enyocha ihe ngosipụta akụrụngwa. Ọbụlagodi ugboro 2 n’afọ, yana n’ile anya myalgia, ekwesịrị ịhapụ lactate dị na plasma.

Ọ ga-ekwe omume iji Formetin yana ngwakọta sulfonylurea ma ọ bụ insulin, yana ịchọrọ nlezianya nke ọkwa glucose ọbara.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

Mgbe ejiri ya dị ka monotherapy, ọgwụ a anaghị emetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ.

Site na njikọta nke Formetin na ọgwụ hypoglycemic ndị ọzọ (usoro sulfonylurea, insulin), ọnọdụ hypoglycemic nwere ike ịmalite ebe ike ịkwọ ụgbọala na ihe omume ndị ọzọ dị ize ndụ nke chọrọ nlebara anya na ọsọ nke mmetụta psychomotor na-akawanye njọ.

Doụbiga ọgwụ ókè:

Ọrịa: lactic acidosis na-egbu egbu nwere ike ịmalite. Ihe kpatara mmepe nke lactic acidosis nwekwara ike ịbụ nchịkọta nke ọgwụ ahụ n'ihi ọrụ ezumike arụrụ yana ọrụ. Ihe mgbaàmà nke mmalite nke lactic acidosis bụ adịghị ike n'ozuzu, ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, iwetulata ahụ ọkụ, mgbu afọ, mgbu olu, iwetulata ọbara, mgbali bradycardia, n'ọdịniihu ọ nwere ike ịbawanye iku ume, anya mmiri, ọgụgụ isi na mmepe nke coma.

Ọgwụgwọ: ọ bụrụ na enwere akara nke lactic acidosis, a ga-akwụsị ọgwụgwọ ya na metformin ozugbo, onye ọrịa kwesịrị ịga ụlọ ọgwụ ngwa ngwa, ebe o kpebisiri ike ịba uru nke lactate, gosipụta nchoputa ahụ. Usoro ọgwụgwọ kachasị dị mma maka iwepụ lactate na metformin n'ahụ ahụ. Ọ bụrụ na ọ dị mkpa, mee ọgwụgwọ Symptomatic.

Mmekorita nke formin na ogwu ndi ozo.

Iji otu ihe eji eme ihe na usoro sulfonylurea, acarbose, insulin, NSAIDs, MAO inhibitors, oxygentetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide na beta-blockers, ọ ga-ekwe omume ịbawanye hypoglycemic mmetụta nke metformin.

Site na iji GCS eme ihe n'otu oge, mgbochi ogwu a na-aralụ aineụ, epinephrine (adrenaline), sympathomimetics, glucagon, homonụ thyroid, thiazide na "loop", ọgwụ phenothiazine na nicotinic acid, mbelata mmetụta hypoglycemic nke metformin ga-ekwe omume.

Cimetidine belatara mkpochapu nke metformin, n'ihi ihe nke lactic acidosis na-abawanye.

Metformin nwere ike ịkụda nsonaazụ anticoagulants (ọgwụ coumarin).

Site na nchịkwa oge nke ethanol, mmepe nke lactic acidosis ga-ekwe omume.

Site na ime nifedipine n'otu oge na -ewe mmado nke metformin na Cmax, na-eji nwayọ nwayọ nwayọ.

Ọgwụ cationic (amlodipine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin) zoro ezo na tubules na-asọrịta mpi nke usoro tubular na, site na usoro ọgwụgwọ ogologo oge, nwere ike ịbawanye Cmax ọgwụ ahụ na 60%.

Ozi izugbe, ihe mejupụtara na ụdị ntọhapụ

Mpempe ụrọ (lee foto) bụ ọgwụ hypoglycemic. Ọgwụ ahụ bụ akụkụ nke ìgwè biguanide, ya mere a na-eji ya na ọgwụgwọ nke ọrịa shuga 2.

Dịka ọ dị na mmemme niile nke otu biguanide, "Formmetin" nwere akụkụ arụ ọrụ - Metformin hydrochloride. O nwere ike ịbụ 0,5, 0.85 ma ọ bụ 1 g.

• sodium croscarmellose,
• magnesium stearate eji na ụlọ ọrụ ọgwụ,
• povidone (polyvinylpyrrolidone) nke dị na irighiri ihe.

Ọgwụ dị na mbadamba ụrọ, ụdị nke dabere na usoro onunu ogwu:

• 0,5 g gburugburu,
• oval biconvex (0.85 na 1 g).

A na-ere mbadamba na nkwakọ kaadiboodu, nke ọ bụla nwere ike ịbụ 30, 60 ma ọ bụ 100 iberibe.

Pharmacology na pharmacokinetics

Ọgwụ "Mpempe" na-emetụta ahụ dịka ndị a:

• na-eji nwayọ nwayọ nwayọ n’ọkpụkpụ glucose.
• na-ebelata ogo glucose nke eriri afọ na-ewe,
• na-akwalite itinye n'ọrụ glucose dị n'ime ọbara,
• na-eduga n'ịbawanyewanye n'uche anụ ahụ na insulin,
• adịghị ebute mmepe nke hypoglycemia,
• lowers triglycerides na LDL
• normalizes ma ọ bụ belata ibu
• na-enyere aka igbari mkpụkọ ọbara.

Ihe eji eme ihe bu ihe eji egosiputa ya, ihe omuma ya na mwepu nke ihe ndi mejuputara.

1. Egwu. Akụkụ dị ike nke ọgwụ ahụ na-abanyekwa na mgbidi nke eriri afọ mgbe ị theụchara ọgwụ ahụ. Usoro ndu ogwu nke ihe omumu bu site na 50% rue 60%. A na-etinye oke ịgwụ ọgwụ ahụ ka awa 2.5 gachara.
2. Nkesa. Ihe mejupụtara ọgwụ ahụ bụ ihe niile emebeghi njikọ na protein plasma.
3. Ojiji. A na-ebupụ mgbakwunye nke mmiri ọgwụ ahụ agbanweghị. Ihe mebere ya na mmamịrị. Oge achọrọ maka ọkara ndụ ọgwụ ahụ bụ site na awa 1.5 ruo 4.5.

N'okwu ahụ mgbe akụkụ nke ọgwụ ahụ na-agbakọ n'ime ahụ, ịkwesịrị ịma ihe ọ nwere ike isi na ya pụta. Ọtụtụ mgbe, ihe kpatara ya bụ arụ ọrụ arụmọrụ na-arụ ọrụ.

Ihe ngosi na contraindications

Ọgwụ ọgwụ dị mkpa n'ọnọdụ ndị a:

• n’ibubiga ibu ókè ma obu oke ibu, mgbe nri adighi adighi nma,
• ya na oria abuo nke obia.

Ekwesighi iji ya "formine" mee ihe naanị maka oke ibu, n'agbanyeghị eziokwu ahụ na ọgwụ ahụ na - enye aka na mfu ya. Illsnweta ọgwụ dị irè yana ịgwọ ọrịa insulin na ndị ọrịa nwere oke oke ibu, nke jikọtara homonụ nke abụọ.

A na-egbochi ọgwụ mgbe ị na-a theụ ọgwụ:

• ketoacidosis
• Coma ma ọ bụ precoma n'ihi ọrịa shuga,
• ọrịa mgbanwe akụrụ na akụrụ,
• ọnọdụ ndị na-eduga na mmepe nke lactic acidosis, gụnyere nkụda obi, mgbanwe na ọbara ọgbụgba, nnukwu oge nke myocardial infarction, mmanya na-egbu ala, akpịrị ịkpọ nkụ.
• nnukwu mmanya na-egbu egbu,
• nnukwu ọrịa na-efe efe,
• ihe ogwugwo
• mmerụ ahụ
• ụta, ihe metụtara nbido nke ihe ndị pụrụ iche (ụbọchị abụọ tupu yana mgbe).
• gbasoo nri ị na-enye ohere ka ị nọrọ na nri ị na-eri kwa ụbọchị nke na-enweghị ihe karịrị calorie 1000,
• inye ara, tinyere mmalite nke afọ ime,
• hypersensitivity na mmiri ọgwụ.

Ntụziaka maka ojiji

Nhọrọ nke usoro onunu ogwu aghaghi ikwughachi ndi dọkịta ma elebara udiri omume ndi ọrịa anya na oria shuga. Ntụziaka ahụ na-egosi usoro ọgwụ a tụrụ aro ha. Ọ nwere ike ịbụ site na 500 ruo 1000 mg kwa ụbọchị.

Emeghari uzo kwesiri ka emechaa ihe ruru ka ụbọchị iri na ise gasịchara ọgwụ mbụ. Na mgbakwunye, ekwesịrị ịhọrọ ya n'okpuru nchịkwa glycemic. Dosebọchị kwa ụbọchị enweghị ike ịdị elu karịa 3000 mg. N'ọtụtụ oge, ọgwụgwọ mmezi chọrọ ị nweta 1500-2000 mg / ụbọchị. Ndị ọrịa nke afọ agadi ekwesịghị ịfe ihe karịrị 1 g nke ihe eji arụ ọrụ.

Mbadamba ụta kwesiri ị drunkụ mmanya mgbe nri. A na-atụ aro ị byụ ọgwụ dọkịta nyere ka nkewa kee ya, werekwa ọgwụ ahụ ugboro abụọ n'ụbọchị. Nke a ga - egbochi ndapụta nsonaazụ gbasara mgbari nri.

Vidiyo si na Dr. Malysheva banyere Metformin na ọgwụ dabere na ya:

Ndị ọrịa pụrụ iche

A na-atụ aro ọgwụ ahụ maka ojiji ọ bụghị maka ndị ọrịa niile.

Agụnyere ụdị ndị ọrịa na ndị otu pụrụ iche:

1. Ndị nne dị ime na ndị na-enye nwa ara. Nyocha gosipụtara na ọgwụ ndị dị na ọgwụ ahụ nwere ike inwe mmetụta na-adịghị mma na ụmụaka n'ime akpa nwa na mgbe amuchara nwa.
2. Ndị ọrịa nwere ọrịa imeju. Ha na-contraindicated na ọgwụ ọgwụ.
3. Ndị ọrịa nwere ọrụ mgbazinye nsogbu. Site na mgbanwe mgbanwe ọrịa, amachibidoro iji ọgwụ eji eme ihe. N'ọnọdụ ndị ọzọ, ọgwụgwọ ọgwụ a ga-ekwe omume, mana n'okpuru nlele mgbe niile na arụmọrụ akụkụ ahụ.
4. Ndị okenye na-arịa ọrịa. Enwere ihe ize ndụ nke lactic acidosis na ndị mmadụ karịa 60 ndị na-arụ ọrụ ike mgbe niile.

Ntụziaka pụrụ iche

Ọgwụ na ọgwụ nwere ụfọdụ atụmatụ:

1. Ndị ọrịa kwesịrị ilebara akụrụ ọrụ anya. Ugboro nke nlere dị otú a bụ ugboro abụọ kwa afọ. Nke a bụ n'ihi eziokwu ahụ bụ na ihe mejupụtara "Mkpụrụ" nwere ike ịgbakọta n'ime ahụ mmadụ ma ọ bụrụ na ọgba aghara na-arụ ọrụ nke akụkụ a.
2. Ọ bụrụ na myalgia emee, a na-atụ aro ịle ọkwa lactate plasma.
3. Ojiji eji "Formmetin" na ngwakọta nke sulfonylurea chọrọ njikwa glycemia.
4. Nsogbu nke hypoglycemia na-abawanye mgbe ejiri ọgwụ ndị a na ọgwụ ndị ọzọ nwere ike belata ọkwa shuga. Ọnọdụ a dị oke egwu n'oge ịkwọ ụgbọala ma ọ bụ itinye aka na ọrụ ọ bụla metụtara mmeghachi omume ngwa ngwa.
5. Iji gbochie lactic acidosis na ndị ọrịa nwere ọrịa metabolic, ekwesịrị ịmalite usoro ọgwụgwọ belata usoro ọgwụgwọ.

Mmetụta akụkụ na ị andụbiga mmanya ókè

Nyocha nke ndị ọrịa mamịrị na-egosi na ọgwụgwọ na "metdị" onye na-ahụ maka ọnya nwere ike so ya na ụfọdụ omume ọjọọ:

1. Banyere mgbaze - ọgbụgbọ, ụtọ nke ọnụ n’ọnụ, ọgbụgbọ, ọnwụ nke agụụ, ihe mgbu n’afọ, ihe iwe.
2. Lactic acidosis na-apụta. Ọnọdụ a chọrọ ịkwụsị ọgwụgwọ maka ihe egwu ịnwụ.
3. Hypovitaminosis na-etolite.
4. Megaoblastic anaemia na-ebute.
5. Hypoglycemia na-amalite.
6. Ihe awọ na-apụta.

An anụbiga ọgwụ ókè, a na-amalite lactic acidosis. N'ọnọdụ ndị dị otú a, ọ dị mkpa ịkwụsị ọgwụgwọ, ọ kwesịrị ịkpọga onye ọrịa n'ụlọ ọgwụ. N'ọnọdụ ụlọ ọgwụ, a na-ekpebi ịba ụba nke lactate iji kwado ma ọ bụ gbaghaa nchoputa ahụ. Ojiji nke hemodialysis dị irè n'ọtụtụ oge maka mwepu nke lactate na metformin.

Njikọ Ọgwụ na Analogs

A na - eme ka mmetụta hypoglycemic dị elu site n'aka ndị a:

• ogwu ogbugba insulin
• Ndị na - egbochi ACE, MAO,
• Acarbose
• Oxytetracycline,
• ihe mgbochi beta
• Ngwurugwu sulfonylurea.

Arụ ọrụ na-ebelata ọgwụ ndị a:

• GKS,
• ogwu mgbochinwa
• adrenaline
• glucagon,
• ọgwụ homonụ eji pathologies nke thyroid gland,
• nnabata ọmiko
• usoro nke phenothiazine, yana acid nicotinic.

Ohere inweta lactic acidosis na-abawanye site na ị theụ ọgwụ "Cimetidine", ethanol.

Ahịa ọgwụ na-eweta ọgwụ dị iche iche na-ebelata shuga.Enwere ike iji ụfọdụ n'ime ha dị ka ndị nnọchi maka nkwadebe "Mpempe", n'ihi ọnụnọ nke metformin hydrochloride na ihe mejupụtara ha.

Echiche onye ọrịa

Site na nyocha nke ndị ọrịa mamịrị banyere ọgwụ ogwu ahụ, anyị nwere ike kwubi na ọgwụ a adabaghị adabara onye ọ bụla, yabụ, tupu iji ya, nyocha nke dọkịta.

Adị m afọ 66 mgbe achọpụtara shuga dị elu. Dọkịta tụrụ aro ị takingụ ọgwụ Formmetin ozugbo. Ihe ọ rụpụtara dị mma. N'ime afọ 2 nke ọgwụgwọ, a na-edebe shuga n'ime 7.5 mmol / L. Ọ bụ ihe na-enye obi ụtọ karịsịa na anyị jisiri ike wepu 11 n'arọ, ma nkụ na-apụ n'anya.

Ruo ọtụtụ ọnwa ka m họrọ ọgwụ iji mezie shuga. A chọpụtara ọrịa shuga ọnwa ise gara aga, mana ọ bụ naanị maka mbadamba ihe ndị a na - eche ka ọ ga - ekwe omume ịbịaru nso na shuga nkịtị. M na-anabata ha na Siofor. N’adịghị ka ọgwụgwọ ndị ọzọ na ọgwụ a, enweghị m nsogbu na mgbaze. Nye onye ọ bụla na-emechabeghị ọgwụ ahụ, ana m akwado ịnwale ya.

M na-agụ nyocha ndị ọzọ ma na-eju m anya na ihe ndị ọzọ rụzuru. Mụ onwe m weere ọgwụ a na isi ọnwụ nke dọkịta. Tupu ọ Metụọ Metformin Teva, enweghị nsogbu ọ bụla. Na ntughari na Formetin n'ime ụbọchị 3, ahụrụ m mmetụta niile dịnụ. Enwere m nkụda mmụọ, enwere m nsogbu ụra, enwere m adịghị ike dị egwu, mana m na-agbachi nkịtị banyere ihe ndị ọzọ. Ekwesighi ị Thisụ ọgwụ a mgbe afọ 60 gachara, mana onweghị onye dọrọ m aka ná ntị. Dịrị nkwubi okwu.

Ofgwọ nke mbadamba 60 nke formin na-adabere na usoro onunu ogwu. Ọ dị ihe dị ka narị ruble 200.