Mbadamba Metformin 1000 mg, 60 PC.
Biko, tupu ịzụrụ Metformin, mbadamba 1000 mg, pọọsụ 60., Lelee ozi banyere ya na ozi dị na weebụsaịtị webụsaịtị nke onye na-emepụta ma ọ bụ kọwaa nkọwapụta nke ụdị akọwapụtara ya na onye njikwa ụlọ ọrụ anyị!
Ihe omuma egosiputara na saịtị a abughi ihe enyere ndi mmadu aka. Onye rụpụtara ya nwere ikike ịme mgbanwe n ’okike, imewe na ịkwakọ ngwaahịa. Foto nke ngwongwo na foto nke egosiri na katalọgụ saịtị ahụ nwere ike ịdị iche na mbido mbụ.
Ozi banyere ọnụahịa nke egosiri na katalọgụ saịtị ahụ nwere ike ịdị iche na nke ahụ n'ezie n'oge etinyebere iwu maka ngwaahịa kwekọrọ.
Omume ọgwụ
Metformin na - egbochi gluconeogenesis n'ime imeju, na - ebelata nnabata nke glucose site na eriri afọ, na - eme ka ojiji nke glucose na - emejuwanye oge, na - emekwa ka ọ nwee mmetụta nke uru ahụ na insulin. Ọ naghị emetụta nzuzo nke insulin site na mkpụrụ ndụ beta nke pancreas, anaghị akpata mmeghachi omume hypoglycemic. Na-ebelata ọkwa nke triglycerides na obere linoproteins dị ala n'ime ọbara. Na-eme ka ahụ gị dị ike ma ọ bụ belata ya. O nwere mmetụta nke fibrinolytic n'ihi mkpochapụ nke plasminogen activates inhibitor anụ ahụ.
Mgbe nchịkwa ọnụ gasịrị, a na-etinye metformin na ngọngọ nri. Bioavailability mgbe ị nwesịrị ọkọlọtọ bụ 50-60%. Cmax na plasma ọbara ruru ihe ruru elekere 2.5 mgbe mmịnye ahụ gasị. Ọ fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Ọ na-agbakọta na gland salvary, akwara, imeju na akụrụ. Ọ bụ akụrụ na-agbanweghi agbanwe. T1 / 2 bụ awa 9-12. Na arụ ọrụ ezumike n’akuku ezighi ezi, nchịkọta ọgwụ ga-ekwe omume.
Elldị shuga abụọ nke ọrịa mellitus na-enweghị ebumnuche nke ketoacidosis (ọkachasị na ndị ọrịa na-ebu oke ibu) na ọgwụgwọ adịghị eri nri, yana insulin, n'ụdị ọrịa shuga nke 2, ọkachasị ogo nke oke ibu, ya na mmegide insulin nke abụọ.
Ihe ngbanwe
- mamịrị ketoacidosis, ọrịa mamịrị, prema, shuga,
- ọrụ ezughi oke,
- ọrịa ọjọọ na-enwe nsogbu nke ịmalite ọrịa akụrụ: akpịrị ịkpọ nkụ (na ọnya afọ, ọgbụgbọ), ahụ ọkụ, ọrịa na-efe efe, hypoxia (ujo, sepsis, akụrụ ọrịa, ọrịa bronchopulmonary).
- ngosipụta a na -adakarị ala nke ọrịa na-adịghị ala ala nke nwere ike ibute mmepe nke hypoxia anụ ahụ (obi ma ọ bụ akụkụ iku ume, nnukwu myocardial infarction),
- ezigbo ịwa ahụ na trauma (mgbe egosipụtara insulin ọgwụ),
- ọrụ imeju na-arụ ọrụ,
- egbu egbu egbu, ị alcoholụ mmanya na-egbu egbu,
- jiri ma ọ dịkarịa ala ụbọchị abụọ tupu yana n'ime ụbọchị 2 mgbe ị mụsịrị redioisotope ma ọ bụ x-ray na ntinye nke ayodiin nwere ọdịiche,
- lactic acidosis (gụnyere akụkọ ihe mere eme),
- rube isi na obere kalori (na-erughị calorie 1000 / ụbọchị),
- ime
- lactation
- hypersensitivity na ọgwụ.
A naghị atụ aro ka iji ọgwụ ahụ mee ihe na ndị mmadụ karịa afọ 60 bụ ndị na-arụ ọrụ anụ ahụ dị arọ, nke ejikọtara ya na oke ihe ize ndụ nke ịmalite ọrịa lactic acidosis n'ime ha.
Nsonaazụ
Site na nri digestive: ọgbụgbọ, ọgbụgbọ, ụtọ otite n'ọnụ, enweghị agụụ, afọ ọsịsa, ọnya afọ, mgbu afọ. Mgbaàmà ndị a bụ ihe a na-ahụkarị na mmalite ọgwụgwọ ma na-apụkarị n'onwe ha. Ihe mgbaàmà ndị a nwere ike belata nhọpụta nke anthocides, ihe dị iche iche nke atropine ma ọ bụ ọgwụ antispasmodics.
Site n'akụkụ nke metabolism: n'ọnọdụ ndị dị ụkọ - lactic acidosis (chọrọ ịkwụsị ọgwụgwọ), na ọgwụgwọ ogologo oge - hypovitaminosis B12 (malabsorption).
Site na akwara hemopoietic: n'ụzọ ụfọdụ - megaloblastic anaemia.
Site na usoro endocrine: hypoglycemia.
Mmeghachi omume nfụkasị ahụ: ọnya anụ ahụ.
Mmekorita
Ekwesighi ka eji Danazol eme ihe oge a iji zere uto hyperglycemic nke ikpeazu. Ọ bụrụ na ọgwụgwọ na danazol dị mkpa ma kwụsịchaa nke ikpeazụ, a chọrọ ndozi nke metformin na ayodiin iji glycemia.
Njikọ ndị chọrọ nlekọta pụrụ iche: chlorpromazine - mgbe ewere ya na nnukwu doses (100 mg / ụbọchị) na-abawanye glycemia, na-ebelata ntọhapụ nke insulin.
Na ọgwụgwọ nke ọgwụ mgbochi na mgbe ịkwụsịsịrị ịhapụ nke ikpeazụ, achọrọ ịgbatị dose nke metformin n'okpuru njikwa glycemia.
Iji otu ihe eji eme ihe na usoro sulfonylurea, acarbose, insulin, NSAIDs, MAO inhibitors, oxygentetracycline, AC inhibitors, clofibrateeri, cyclophosphamide, β-blockers, ọ ga-ekwe omume ịbawanye hypoglycemic mmetụta nke metformin.
Site na iji GCS eme ihe n'otu oge, mgbochi ogwu a na-aralụ a ,ụ, epinephrine, sympathomimetics, glucagon, homonụ thyroid, thiazide na loop diuretics, ọgwụ phenothiazine, usoro nicotinic acid, mbelata mmetụta hypoglycemic nke metformin ga - ekwe omume.
Cimetidine belatara mkpochapu nke metformin, nke a na - ebute oke nke lactic acidosis.
Metformin nwere ike ịkụda nsonaazụ anticoagulants (ọgwụ coumarin).
Mmanya na-aba n'anya na-eme ka ohere mmadụ nwere ịrịa lactic acidosis n’oge ị alcoholụbiga mmanya ókè, karịchaa n’ihe metụtara ibu ọnụ ma ọ bụ ịgbaso nri kalori, yana ọrịa imeju.
Etu ị ga-esi, usoro nchịkwa na usoro onunu ogwu
Ọ bụ dibia a ka edobere ọgwụ a n’otu, dabere n’ọkwa glucose dị n’ọbara.
Usoro mbu bu 500-1000 mg kwa ubochi (mbadamba 1-2). Mgbe ụbọchị 10-15 gachara, mmụba ọzọ na-abawanye ụba n'oge enwere ike dabere na ọkwa glucose ọbara.
Ọgwụ nchekwa ọgwụ na-abụkarị 1500-2000 mg kwa ụbọchị. (3-4 mbadamba) Oke kachasị bụ 3000 mg kwa ụbọchị (mbadamba 6).
N'ime ndị ọrịa agadi, ọgwụ a na-atụ aro kwa ụbọchị ekwesịghị gafere 1 g (2 mbadamba).
Ekwesịrị iji mbadamba Metọdin were obere mmiri mmiri (iko mmiri) zuru oke ma ọ bụ ozugbo nri ahụ gasịrị. Iji belata nsonaazụ si eriri afọ, a ga-ekewa ihe ị na-eme kwa ụbọchị n'ime usoro 2-3.
N'ihi oke ịba ụba nke lactic acidosis, a ga-belata ọgwụ ahụ ebe enwere nnukwu nsogbu metabolic.
Dodoụbiga ya ókè
Site na mmachi nke Metformin, a acid acidisis nwere nsonaazụ na-egbu egbu ga-ekwe omume. Ihe kpatara mmepe nke lactic acidosis nwekwara ike ịbụ nchịkọta nke ọgwụ ahụ n'ihi ọrụ ezumike arụrụ yana ọrụ.
Ihe mgbaàmà nke lactic acidosis: ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, okpomoku ahụ dị ala, mgbu afọ, olu mgbu, n'ọdịniihu enwere ike ịba ụba iku ume, ọgbụgbọ, nsụda mmụọ na mmepe nke coma.
Ọgwụgwọ: a bụrụ ihe ịrịba ama nke lactic acidosis, a ga-akwụsị ọgwụgwọ na Metformin ozugbo, onye ọrịa kwesịrị ịga ụlọ ọgwụ ngwa ngwa, ebe o kpebisiri ike ịba uru nke lactate, gosipụta nchoputa ahụ. Measurezọ kachasị dị irè maka iwepu lactate na metformin n'ahụ ahụ bụ hemodialysis. A na-eme ọgwụgwọ Symptomatic.
Site na usoro ọgwụgwọ ejikọtara na Metformin na sulfonylureas, hypoglycemia nwere ike ịmalite.
Ntụziaka pụrụ iche
N'oge ọgwụgwọ, ọ dị mkpa iji nyochaa ọrụ akụrụngwa. Ọbụlagodi ugboro 2 n’afọ, yana n’ile anya myalgia, ekwesịrị ịhapụ ọdịnaya lactate dị na plasma. Na mgbakwunye, otu ugboro kwa ọnwa isii ọ dị mkpa iji chịkwaa ọkwa nke creatinine n'ọbara ọbara (ọkachasị ndị ọrịa nke afọ agadi). Ekwesighi inye usoro Metformin ka ọ bụrụ na ọkwa creatinine dị n’ọbara dị elu karịa 135 μmol / L n’ime ụmụ nwoke na 110 μmol / L.
Ikekwe ojiji nke ọgwụ Metformin yana njikọta usoro sulfonylurea. N'okwu a, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose ọbara.
Nkeji iri anọ na asatọ tupu ma ọ bụ n’ime elekere iri anọ na asatọ gbasara rediopaque (urography, iv angiography), ị kwesịrị ịkwụsị ị were Metformin.
Ọ bụrụ na onye ọrịa ahụ na-arịa ọrịa bronchopulmonary ma ọ bụ ọrịa na-efe efe nke akụkụ ahụ akụkụ, ekwesịrị ịgwa dọkịta na-aga ya ozugbo.
N'oge ọgwụgwọ, ị kwesịrị ịhapụ ị alcoholụ mmanya na ọgwụ nwere ethanol. .
Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa
Ojiji iji ọgwụ ahụ monotherapy anaghị emetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ.
Mgbe agbakwunyere Metformin na ndị ọzọ hypoglycemic (ihe dị n'ụkpụrụ sulfonylurea, insulin), ọnọdụ hypoglycemic nwere ike ịmalite ebe ike ịkwọ ụgbọala na itinye aka na ọrụ ndị ọzọ dị ize ndụ chọrọ nlebara anya na mmeghachi omume psychomotor ngwa ngwa.
