Lozarel na - enyere aka ịhazi ọbara mgbali elu

A na-eji Lozarel ọgwụ eme ihe na cardiology, endocrinology na nephrology. Ntuziaka maka ojiji nwere ngwaahịa maka ojiji ngwaahịa a kwesịrị ekwesị, dabere na atụmatụ ụlọ ọgwụ.

Ndabere nke ọgwụ bu losartan potassium na 50 mg. Ihe ndi ozo gunyere silikon dioxide, magnesium stearate, lactose, stachi. Ngwakọta ahụ nwekwara celclose microcrystalline.

Mpempe mwepụta

Enwere ike ịzụta ọgwụ a na mbadamba mbadamba, nke a na-etinye ya na mbadamba agwa dị mbadamba 10. N'ime otu ngwugwu enwere 3 blisters.

Mbadamba ahụ nwere agba ọcha (obere oge na-acha odo odo) na ọdịdị gburugburu. N’otu akụkụ dị n’ihe ize ndụ. Ihe dị n’elu mbadamba nkume ahụ bụ ihe mkpuchi kpuchiri.

Ọgwụgwọ

Angiotensin 2 bụ enzyme nke, site na ijikọ ya na ndị na-anabata ya na obi, akụrụ na adrenal gland na-eduga n'ịbelata oghere nke ọbara ha. Ọ na-emetụtakwa ntọhapụ nke aldosterone. Mmetụta ndị a niile na-ebute mmụba ọbara mgbali.

Losartan na-egbochi ọrụ nke angiotensin 2, n'agbanyeghị usoro e guzobere ya. N'ihi nke a, mgbanwe ndị a na-ebute ahụ:

• belata mkpokọta akwara, vaskụla,
• ọbara aldosterone etoju ibelata
• ọbara ọgbụgba na-ebelata
• ọkwa nrụgide na akwara ọbara na-ebelata.

Ọbara ọbara na-ebelata n'ihi obere diuretic mmetụta nke ọgwụ. Site na nnabata oge niile, a ga-ebelata ihe ize ndụ nke ọbara mgbali obi, ịnagide mmega ahụ n'ebe ndị enwere nsogbu myocardial nọ ka ọ dị mma.

Mmetụta kachasị na-apụta ụbọchị 21 mgbe mmalite nke nchịkwa. A na-ahụta ọgwụ antihypertensive n'ime otu ụbọchị.

Ejiri Lozarel mee ihe maka akwara, ọrịa gbasara akụrụ na metabolism metabolia na-arịa ya. A gosipụtara ọgwụ ahụ maka mmụba ọbara mgbali elu n'ihi ọrịa na-akpata ọrịa, ma ọ bụ ọbara mgbali nke etiology na-amaghị.

A na-egosi ọgwụ ahụ maka nkụchi obi (nkụchi obi), nke na - anaghị ewepụ angiotensin-na-emegharị ndị na - egbochi enzyme. Site na nkwonkwo ọbara mgbali elu, afọ ndụ, hypertrophy aka ekpe ventricular na ihe ndị ọzọ, a na-eji ya belata onwu na ohere nke ọghọm vaskụla (nkụchi obi, ọrịa strok).

A na-eji ọgwụ ahụ eme ihe maka nsogbu nke ụdị ọrịa shuga 2 - nephropathy, ebe ọ na-ebelata ohere nke ọrịa.

Ntụziaka maka ojiji

A na-ewere Losartan 1 oge kwa ụbọchị. A na-eji 50 mg iji gwọọ ọbara mgbali elu. Ọ bụrụ na edepụtara ndị otu ọgwụ ọgwụ ọgụ ọzọ, bido ọkara mbadamba. Ọ bụrụ na ọ dị mkpa, mee ka ọgwụ ahụ gaa na mg mg 100, nke enwere ike iwere ya otu ugboro ma ọ bụ kewaa abụọ.

N’ime nkụchi obi na-adịghị ala ala, a na-atụ aro opekempe nke 12.5 mg. Daysbọchị asaa ọ bụla, ọ dị okpukpu abụọ, jiri nwayọ na-abawanye ruo 50 mg. N'okwu a, ha na-elekwasị anya na ike ọgwụ ahụ. Site na iji ọkara (25 mg), ọ bụrụ na onye ọrịa nwere akụrụ ma ọ bụ imeju, ọ nọ na hemodialysis.

Iji dozie proteinuria na ọrịa shuga, a na-enye ọgwụ ahụ na ọgwụ nke 50 mg / ụbọchị. Oke kachasị kwa ụbọchị maka ọrịa a bụ 100 mg.

N'ikuku enweta nri esighi na nri, o kwesịrị ịdị kwa ụbọchị n'otu oge.

Ihe ngbanwe

Edere potassium Losartan maka ụdị ndị ọrịa a:

• na ịnabatacha glucose ma ọ bụ galactose,
• anabataghi glucose,
• galactosemia
• n'okpuru afọ 18
• ime
• lactating
• ndị ekweghị na akụrụngwa ọgwụ a.

Nyochaa ọnọdụ chọrọ nhọpụta nke ọgwụgwọ maka akụrụ ma ọ bụ mmebi imeju, akwara akwara stenosis (akụkụ abụọ nwere ma ọ bụ otu akụrụ), na mbelata olu nke na-ekesa ọbara nke etiology ọ bụla. N'iji nlezianya mee ihe, a na-eji Lozarel mee ihe maka eleghara elektrolyte anya.

Ihe ngosi maka ojiji

Edere ọgwụ Lozarel ma ọ bụrụ na enwere:

1. Ihe ịrịba ama doro anya nke ọbara mgbali elu.
2. Mbelata ihe ize ndụ nke ọrịa obi na akwara na ndị mmadụ na-arịa ọbara mgbali elu ma ọ bụ mgbali elu ventricular aka ekpe, nke a na-egosipụta site na mbelata ọnụ ọgụgụ ọrịa obi, ọrịa strok na infarction ụbụrụ.
3. Inye nchedo akụrụ n’ime ndị ọrịa nwere ụdị shuga 2.
4. Mkpa belata proteinuria.
5. Ọrịa obi na-adịghị ala ala na ọdịda ọgwụgwọ site na ndị na - egbochi ACE.

Nsonaazụ

Nnabata ọgwụ a nwere ike ibute mmeghachi omume ọjọọ, nke na-esighi ike ma anaghị achọ nkwụsị ya. E gosipụtara ha na tebụl.

Mmeghachi omume ọjọọ na-abụghị nke otu ọ bụla gụnyere gout.

Doụbiga ihe mgbaàmà ókè

Dodoụbiga mmanya ókè nwere ụdị ngosipụta a: osisa obi ọsọ ọsọ, mbelata ọbara mgbali elu, obi a na-adịghị ahụkebe mgbe ị na-akpali ihe ikpu.

A na-eji ihe ndị na-eme ka mmiri ghara ịdị na-arụ ọrụ na ndị nnọchi anya iji dozie ọnọdụ. Usoro ọgwụgwọ nke ịba ọcha n'anya enweghị mmetụta, ebe ọ bụ na ewepụghị losartan na usoro mgbasa ozi nke ndu n'ụzọ a.

Mkparịta ụka ọgwụ ọjọọ

Combinedme ihe jikọtara ya na ihe diureta sitere na otu ndị na - eme potassium, yana nkwadebe nwere potassium ma ọ bụ nnu ya, na - ebulite ohere nke hyperkalemia. Ejiri mmanu Lozarel na sọlfọ lithium, ebe ntinye lithium na ọbara nwere ike ịba ụba.

Ojiji nke ọgwụ ahụ na fluconazole ma ọ bụ rifampicin nwere ike belata mkpụkọ metabolite na-arụ ọrụ na plasma. Mbelata ịdị mma nke ọgwụ na-apụta mgbe ejiri ọgwụ mgbochi mgbochi mkpali na - abụghị ọgwụ steroidal na-akwado ya.

Losartan adịghị eso ọgwụ ndị dị otú ahụ emekọrịta:

• warfarin
• hydrochlorothiazide,
• digoxin
• phenobarbital,
• cimetidine
• erythromycin
• ketoconazole.

Ọgwụ a na - eme ka mmetụta nke ckers-blockers, diuretics na ọgwụ ndị ọzọ belata ọbara mgbali elu.

Ntụziaka pụrụ iche

Losartan emetụtaghị itinye uche, yabụ mgbe iwere ya, ị nwere ike gbaa ụgbọ ma rụọ ọrụ. N'ọnọdụ ebe ọgwụ ọghọm ga-efu, mbadamba ọgwụ na-esote na-a immediatelyụ mmanya ozugbo ohere dịịrị. Ọ bụrụ na oge eruola ị nextụ ọgwụ ọzọ, ha na-a itụ ya otu usoro - 1 mbadamba (anaghị atụ aro mbadamba 2).

Site na iji ọgwụ ogologo oge, a na-enyocha ọkwa nke plasma K. Ọ bụrụ na eji ọgwụ ahụ eme ihe megidere ndabere nke nnukwu ọgwụ diuretics, enwere ihe ize ndụ nke hypotension. Lozarel na-abawanye larịị nke creatinine na urea n'ihe banyere akụrụ akwara akwara nke otu akụrụ, yana yana obere arịa ndị a.

Analogs: Presartan, Lozap, Cozaar, Blocktran, Lorista, Cardomin-Sanovel.

Ihe analogues na-efu: Vazotens, Losartan.

Dabere na ọtụtụ nyocha, Lozarel na-anabata nke ọma na iji ogologo oge, na-achịkwa nrụgide ahụ n'ehihie. Ọ bụ ihe a ma ama n'etiti ndị ọrịa, ọ na-abụkarị ndị ọkachamara na - ede ya - ndị na - agwọ ọrịa, kadiologists, ndị dọkịta ezinụlọ. Nyocha ụfọdụ nwere ihe ngosipụta nke mmeghachi omume ọjọọ.

Nchekwa na ndu

Enwere ike iji ọgwụ ahụ mee ihe n'ime afọ 2 site na ụbọchị nke ewepụtara. A na-echekwa ya n'ime ụlọ nke okpomọkụ ya anaghị agafe 25 Celsius.

A na-atụ aro ọgwụ a ka ewere ya naanị mgbe nyocha, laabu, nyocha ngwa ọrụ, njirimara nke pathology concomitant. Iji Lozarel onwe ya nwere ike bute nsogbu.

Nsonaazụ

Mgbe ị na-emeso Losarel, mmetụta ọ na-adịkarịghị egosipụta, ọ nweghịkwa mkpa ịkwụsị ọgwụ.

N'ime ndị nwere nsogbu na akụrụngwa obi, nsogbu ndị a na-apụta mgbe ụfọdụ:

Site na imebi eriri afọ, ọgbụgbọ, mgbu afọ, afọ ntachi, eze mgbu, ịba ọcha n'anya, gastritis, na nkwarụ uto na-apụtakarị. Ọrịa ndị a anaghị adịkarị na-eto eto.

A bịa na ọnya oria, ọbara ọgbụgba na akpụkpọ ahụ, akpụkpọ akọrọ, na ịchafụ oke nwere ike ọgaghị adị.

N'akuku ọnya, itching, ihe ọnya na akpukpo aru, na hives apụta.

Site n'akụkụ akụkụ akwara ahụ, enwere mgbu na azụ, ụkwụ, obi, ogbu na nkwonkwo, ihe mgbochi.

Site na imebi sistem iku ume, ụkwara, imi mkpọchi, bronchite, na-efe efe.

Na sistemụ urinary - arụ ọrụ akụrụ, ọrịa urinary tract.

Usoro onunu ogwu na nhazi

Ọ dị mkpa iburu mbadamba nkume ndị ahụ n'ime otu ugboro n'ụbọchị, n'agbanyeghị nri ahụ.

Site na ọbara mgbali elu mbido ya na ntinye ya bụ usoro a na-ahụkarị 50 mg otu ugboro kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, enwere ike ibute ya ruo 100 mg.

Maka ndị ọrịa na ọrịa obi na-adịghị ala ala bulie ọgwụ izizi nke 12.5 mg, ma nwezie okpukpu abụọ kwa izu, na-ewetara 50 mg kwa ụbọchị.

Na ụdị ọrịa shuga 2, nke proteinuria na-esonyere, ọgwụ mbụ a tụrụ aro kwesịrị ịbụ 50 mg otu ugboro n'ụbọchị.

Mgbe ị na-eme ọgwụgwọ, dabere n'ọbara ọbara onye ọrịa ahụ, a na-ahapụ ya ka iwelie ọgwụ kwa ụbọchị ka ọgwụ ahụ ruo 100 mg.

N'ihi na belata ihe ize ndụ nke ịmalite ọrịa obi ndagide na ndị mmadụ nwere ọbara mgbali elu, yana ogwe aka ekpe ventricular, a na-ahọrọ ọgwụ mbido 50 mg otu ugboro n’ụbọchị. N'okwu a, a ga-eji nwayọ belata ọgwụ ahụ ruo 100 mg kwa ụbọchị.

Usoro na ọnọdụ nchekwa

Na-echekwa na okpomọkụ agaghị akarị 25 Celsius. Debe ọgwụ ahụ ka ụmụaka ghara iru ya.

Exbọchị mmebi Ọgwụ bụ afọ 2.

Ejila ọgwụ ahụ mgbe ọ gwụchara.

Ọnụ ọnụ ọgwụ ọgwụ Lazorel dịgasị dabere na onye nrụpụta na netwọ nke ụlọ ahịa ọgwụ. na Russia na nkezi ọ na-efu site na 200 rubles.

Na Ukraine ọgwụ ahụ agbasaghị ebe niile ma na-efu ihe dịka 200 UAH.

Ọ bụrụ na ọ dị mkpa, ịnwere iji ọgwụ ọgwụ ndị a dochie "Lozarel":

• Brozaar
• Ngọngọ
• Vero-Losartan
• Vazotens
• Cardomin-Sanovel
• Zisakar
• Cozaar
• Karzartan
• Lozap,
• Lakea
• Losartan A,
• Losartan Canon
• "Losartan potassium",
• Losartan Richter,
• Losartan MacLeods,
• Losartan Teva
• "Lozartan-TAD",
• Losacor
• Lorista
• Presartan
• Lotor
• "Renicard."

Iji ọgwụ analorọ maka ọgwụgwọ ka achọrọ karịsịa n'ọnọdụ ebe onye ọrịa ahụ nwere nnabata onwe ya na ọgwụ ahụ. Agbanyeghị, naanị dọkịta nwere ike inye gị ọgwụ ọ bụla.

Enwere ike ịchọta nyocha nke ọgwụ ahụ na Internetntanetị, dịka ọmụmaatụ, Anastasia dere, sị: “Ọrịa shuga m na-akpata oke nhụjuanya. N’oge na-adịghị anya, achọtara m ihe ngosipụta ọhụrụ nke ọrịa a. Achọpụtara m na nephropathy. Dọkịta ahụ nyere ọtụtụ ọgwụ dị iche iche, gụnyere Lozarel. Ọ bụ ya nyeere aka weghachi ọrụ akụrụ niile na-arụ ọrụ nke ọma. Ọkpụkpụ ụkwụ adịghịzị apụ. ”

Enwere ike ịchọta nyocha ndị ọzọ na njedebe nke edemede a.

A ghọtara Lozarel ọgwụ dị ka ọgwụ dị irè na ọgwụgwọ ọbara mgbali elu na nkụchi obi. O nwere usoro analogues na-agbasawanye nke nwere nnukwu ihe mejupụtara ya, a naghị akwado ya maka nsogbu nke imeju na akụrụ, yana n'oge afọ ime na n'okpuru afọ 18. Iji zere ihe ndị ga - eme, a na - atụ aro ka ị theụ ọgwụ ahụ nke ọma dịka dọkịta nyere n'iwu.

Mpempe usoro onunu ogwu

Mbadamba ihe mkpuchi vidiyo 12.5 mg, 25 mg, 50 mg, 75 mg, 100 mg

Otu mbadamba ihe mkpuchi nwere

ihe na - arụ ọrụ - losartan potassium 12.5 mg ma ọ bụ 25 mg ma ọ bụ 50 mg ma ọ bụ 75 mg ma ọ bụ 100 mg

ndị na-ahụkarị: microcrystalline cellulose, povidone, sodium sitashi glycolate (ụdị A), silicon dioxide colloidal anhydrous, magnesium stearate,

ihe mkpuchi ihe nkiri: opadray ọcha (OY-L-28900), lactose monohydrate, hypromellose, titanium dioxide (E 171), macrogol, indigo carmine (E 132) varnish aluminom (maka onunu ogwu 12.5 mg).

Mbadamba ihe eji etinye ihe nkiri, oval, acha anụnụ anụnụ, nke a kanyere na "1" n'otu akụkụ (maka usoro onunu ogwu nke 12.5 mg).

Mbadamba ụrọ a kpụrụ akpụ bụ oval, na-acha ọcha na agba, na-enwe ọkaibe na akụkụ ọ bụla yana “2” na-ese ihe n'otu akụkụ (maka onunu ogwu nke 25 mg).

Mbadamba ihe eji etinye fim bụ oval, na-acha ọcha na agba, na-enwe ọkaibe na akụkụ nke ọ bụla na ihe osise "3" n'otu akụkụ (maka ọgwụ nke 50 mg).

Ere ọgwụ, nke gbara ihe nkiri, nke gbara ọcha, nwere ihe ọghọm abụọ n’akụkụ ọ bụla ma kọọ “4” n’akụkụ otu (maka ọgwụ nke 75 mg).

Ere ọgwụ, nke a na-egosi n'ihe nkiri, nke gbara agba, na-acha ọcha, nwere ihe egwu atọ n'akụkụ ọ bụla ma kanyere "5" n'otu akụkụ (maka ọgwụ nke 100 mg).

Omume ọgwụ

Mgbe nchịkwa ọnụ gasịrị, losartan na-agbaso nke ọma ma na-emezi usoro metabolism site na nguzobe nke metabolic acid na-arụ ọrụ, yana metabolites ndị ọzọ na-adịghị arụ ọrụ. Akpụrụ bioav adị nke losartan n'ụdị mbadamba ihe dịka 33%. A na-erute nkezi nke losartan na metabolite na-arụ ọrụ ya mgbe elekere 1 gachara ma ọ bụ awa 3-4 gachara.

Losartan na metabolite ya na-arụ ọrụ bụ ≥ 99% na-emetụta protein ndị na-enye plasma, tumadi na albumin. Olu nke nkesa losartan bu lita 34.

Ihe dị ka 14% nke losartan, mgbe a na-elekọta ya n'olu ma ọ bụ mgbe a na-ewere ya ọnụ, na-agbanwe na metabolite na-arụ ọrụ ya. Mgbe nchịkwa intraven ma ọ bụ mmalite nke 14C akpọrọ losartan potassium, redio ahụ nke plasma na-ekesa bụ ihe kachasị na losartan na metabolite na-arụ ọrụ. A hụrụ obere losartan na metabolite ya na-arụ ọrụ na ihe dị ka 1% nke ndị ọrịa n'ọmụmụ ihe ahụ. Na mgbakwunye na metabolite na-arụ ọrụ, a na-akpụkwa metabolites na-adịghị eme ihe.

Mkpochapu plasma nke losartan na metabolite na-arụ ọrụ bụ ihe dịka 600 ml / nkeji na 50 ml / nkeji, n'otu n'otu. Nwepu nke losartan na metabolite ya na-arụ ọrụ bụ ihe dịka 74 ml / nkeji na 26 ml / nkeji, n'otu aka ahụ. Mgbe ị na-abanye losartan, ihe dị ka 4% nke ọgwụ a na-agbanwegharị na mmamịrị yana ihe dị ka 6% nke dose ahụ na-apụ na mmamịrị dị ka metabolite na-arụ ọrụ. Pharmacokinetics nke losartan na metabolite na-arụ ọrụ bụ ahịrị mgbe iwebata potassium losartan na doses ruo 200 mg.

Mgbe imesachara, ihe ndị dị na losartan na metabolite na-arụ ọrụ na plasma ọbara na-ebelata nke ukwuu, ọkara ndụ ikpeazụ bụ ihe dị ka awa 2 na awa 6-9, n'otu n'otu.

Losartan na metabolite na-arụ ọrụ ya anaghị agbakọba ụba na plasma ọbara mgbe a na-eji 100 mg mg otu ugboro kwa ụbọchị.

Losartan na metabolite na-arụ ọrụ ya bụ ihe dị na akwara na mmamịrị. Mgbe nchịkwa ọnụ gachara, ihe dị ka 35% na 43% ka etachara na mmamịrị ahụ, yana 58% na 50% nwere ọnya ndị ọzọ.

Pharmacokinetics na otu ọrịa dị iche iche

N'ime ndị ọrịa agadi nwere arịa ọbara mgbali elu, mkpokọta nke losartan na metabolites na-arụ ọrụ ya na plasma ọbara adịghị iche na nke ndị ọrịa na-eto eto nwere ọbara mgbali elu.

N'ime ndị ọrịa nwere ọbara mgbali ọbara ụmụ nwanyị, ọkwa nke losartan na plasma ọbara dị okpukpu abụọ karịa nke ndị ọrịa nwere ọbara mgbali elu nwoke, ebe ọkwa nke metabolites na-arụ ọrụ na plasma ọbara adịghị iche na ụmụ nwoke na ụmụ nwanyị.

N'ime ndị ọrịa nwere ọria ị alcoụ mmanya na-egbu egbu na-egbu egbu ruo n'ọbara, ọkwa nke losartan na metabolites na-arụ ọrụ na plasma ọbara mgbe nchịkwa ọnụ bụ 5 na 1.7 ugboro, n'otu n'otu, dị elu karịa na ndị ọrịa ụmụ nwoke na-eto eto.

N'ime ndị ọrịa nwere nkọwapụta nke creatinine karịa 10 ml / min, plasma concentrations nke losartan agbanweghị. E jiri ya tunyere ndị ọrịa nwere ọrụ ezumike nkịtị, na ndị ọrịa na hemodialysis, AUC (mpaghara n'okpuru oge ịta ahụhụ) maka losartan dị ihe dị ka ugboro abụọ karịa.

N'ime ndị ọrịa nwere ọdịda akụrụngwa ma ọ bụ na ndị ọrịa na-arịa hemodialysis, ihe ndọpụ plasma nke metabolite na-arụ ọrụ bụ otu.

Losartan na metabolite na-arụ ọrụ ya adịghị ama jijiji site na hemodialysis.

Losartan bụ antagonistin II receptor antagonist (ụdị AT1) maka ọnụ. Angiotensin II - vasoconstrictor dị ike - bụ hormone na-arụ ọrụ nke sistemụ renin-angiotensin na otu ihe dị mkpa na pathophysiology nke ọbara mgbali elu. Angiotensin II na-ejikọ ndị na-anabata AT1, nke a na-ahụ n'ọtụtụ akwara (dịka ọmụmaatụ, na akwara umeji nke arịa ọbara, akwara adrenal, akụrụ na obi), na-ekpebi ọtụtụ mmetụta ndu dị mkpa, gụnyere vasoconstriction na ntọhapụ aldosterone.

Angiotensin II na - akpalitekwa ịbawanye uru akwara dị mma.

Losartan na-egbochi ndị na - anabata AT1. Losartan na metabolcologically na-arụ ọrụ metabolites - carboxylic acid (E-3174) - na-egbochi mmetụta physiologically pụtara nke angiotensin II, n'agbanyeghị isi iyi ma ọ bụ ụzọ nke njikọta.

Losartan enweghị mmetụta na-emegide onwe ya, ọ naghị egbochi ndị ọzọ nnabata homonụ ma ọ bụ ọsịdụ ion na-etinye aka na nhazi nke sistem. Ọzọkwa, losartan anaghị egbochi ACE (kininase II), enzyme nke na-akwalite mbibi nke bradykinin. N'ihi nke a, ọnaghị enwe mmụba na nsonaazụ ndị ọ bụla na-agba ume na bradykinin.

N'oge a na-eji ọgwụ ọgwụ Lozarel kpochapụrụ mmeghachi omume na-adịghị mma nke angiotensin II na renin secretion na-ebute mmụba na ọrụ plasma renin (ARP). Mmụba dị otú ahụ na-eduga n'ịba ụba nke angiotensin II na plasma ọbara. N'agbanyeghị mmụba a, ọrụ antihypertensive na mbelata nke ịhapụ aldosterone na plasma ọbara na-adịgide, nke na-egosi mmachi dị mma nke ndị na-anabata angiotensin II. Mgbe ịkwụsịsịrị losartan, ọrụ plasma renin na ọkwa angiotensin II maka ụbọchị 3 laghachi na ntọala.

Ma losartan na isi metabolite ya nwere mmekọrịta dị elu maka ndị na-anabata AT1 karịa maka AT2. Metabolite nọ n'ọrụ bụ ugboro 10 ruo 40 karịa ike losartan (mgbe a gbanwere ya ka ọ bụrụ oke).

Otu losartan dị na ndị ọrịa nwere mgbali elu site n'ọbara ruo n'ọbara na-egosi mbelata mmụba dị ukwuu na mgbali ọbara systolic na ọbara mgbali. Mmetụta kachasị nke losartan na-etolite 5-6 awa mgbe nchịkwa gasịrị, ọgwụgwọ ọgwụgwọ na-adịgide awa 24, ya mere o zuru iji were ya otu ugboro n'ụbọchị.

Pharmacodynamics na pharmacokinetics

Losartan bụ antagonistin nke abụọ na-anabata ihe nnabata (ụdị AT1).

• na-ejikọ ndị na-anabata AT1, nke dị na akwara umeji akwara nke arịa ọbara, obi, akụrụ yana yana gland adrenal,
• nwere mmetụta vasoconstrictive, wepụtara aldosterone,
• na - egbochi angiotensin nke abụọ
• adịghị enye aka na mmechi nke kinase II - enzyme nke na-ebibi bradykinin.

“Lozarel,” dị ka nkọwa nke ọgwụ ahụ gosiri, na-amalite ime ihe ozugbo. Mgbe otu elekere gasịrị, ịta lazortan ruru ogo ọ kachasị, nsonaazụ ahụ na-adịgide ruo awa 24. Izu ike, nrụgide ahụ na-ebelata awa 6 mgbe ị theụ ọgwụ. A na-ahụkarị ezigbo antihypertensive mmetụta mgbe izu 3-6 gachara. Losartan na-ejikọ akụkụ nke albumin na 99%, site na akụrụ na site na eriri afọ ya.

Dodoụbiga ya ókè

Mgbaàmà: Onwebeghị nsogbu ịdoụ ọgwụ ọ haveụ haveụ a kọrọ. Mgbapu akachaghị anya nke ịdoụbiga mmanya ókè ga-abụ hypotension arterial, tachycardia, bradycardia nwere ike ime n'ihi mkpali parasympathetic (vagal).

Ọgwụgwọ: Mgbe hypotension Symptomatic mere, ekwesịrị ịnye ya nkwado. Ọgwụgwọ na-adabere n'ogologo oge gafechara mgbe ị nwusịrị Lozarel, yana ụdị na mgbaàmà ahụ. E kwesiri inye ihe kachasi mkpa iji dozie obi mmadu. Ebumnuche nke carbon na-arụ ọrụ. Nlekota oru di nkpa. Usoro ịba ọcha n'anya adịghị arụ ọrụ, ebe ọ bụ na losartan ma ọ bụ metabolite na-arụ ọrụ adịghị nke pụtara n'oge a na-agwọ ya.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, losartan na-etinye obi gị dum na eriri afọ. Na ụzọ mbụ gafere, ọ na - eme metabolism site na ntinye ya na ntinye nke CYP2C9 isoenzyme na nguzobe metabolite na - arụ ọrụ. Usoro bioavailability nke losartan dị ihe dịka 33%. Oke ịta (C_max) nke ihe na-arụ ọrụ Lozarel na ọbara ọbara na-eru mgbe ihe dị ka elekere 1 gasịrị, yana metabolite na-arụ ọrụ na-arụ ọrụ mgbe awa 3-4 gachara. Nri oriri na-eme ya n'otu oge emetụtaghị bioav adị nke losartan. N'ihe ruru 200 mg, losartan na-ejikwa ọgwụ ọgwụ linear.

Indmegide protein ndị dị n'ọbara plasma (ọkachasị na albumin) - ihe karịrị 99%.

Ise_d (olu ekesa) bu lita 34.

Ihe fọrọ nke nta ka ọ ghara ịbanye n'ime mgbochi ụbụrụ.

Ihe ruru 14% nke ọgwụ onhu losartan ka agbanwere ka ọ bụrụ metabolite na-arụ ọrụ.

Mkpochapu plasma nke losartan bụ 600 ml / min, mwepụ nke akwara bụ 74 ml / min, metabolite ya na-arụ ọrụ bụ 50 ml / min na 26 ml / min, karị.

Ihe dị ka 4% na-apịpụta site na akụrụ na-agbanweghi, rue 6% nke ịnakwere ụdị n'ụkpụrụ metabolite nọ n'ọrụ. A na-ahapụ izu ike site na eriri afọ.

Ndụ ọkara ikpeazụ nke ihe na-arụ ọrụ mgbe niile bụ ihe dị ka awa 2, metabolite na-arụ ọrụ ya - ruo awa 9.

Na-emegide nzụlite nke Lozarel na ọgwụ kwa ụbọchị nke 100 mg, a na-ahụ ntakịrị nchịkọta nke losartan na metabolite na-arụ ọrụ na plasma ọbara.

Site na ịdị nro dị nro nke ọrịa imeju na-egbu egbu, mkpokọta nke losartan na-abawanye ugboro 5, yana metabolite na-arụ ọrụ - oge 1.7, ma e jiri ya tụnyere ndị ọrịa na-enweghị ọrịa a.

Ntinye uche nke losartan na plasma ọbara na ndị ọrịa nwere njigide creatinine (CC) karịa 10 ml / min yiri nke ahụ na ndị ọrịa nwere ọrụ mkpo nkịtị. N'iji CC erughi 10 ml / min, uru nke mkpokọta ọgwụ (AUC) na plasma ọbara na-ebili ihe dị ka ugboro abụọ.

Site na iji hemodialysis, losartan na metabolite na-arụ ọrụ adịghị ewepụ ahụ.

N'ime ụmụ nwoke nwere ọbara ọgbụgba akwara ọrịa afọ, ogo ịgwọ ọgwụ na plasma ọbara adịchaghị iche na ụdị ụmụ ntorobịa.

Ebe ọbara ọgbụgba na-arịa ọbara nwa dị na ụmụ nwanyị, ihie ugwu nke losartan ji okpukpu abụọ karịa nke ụmụ nwoke. Ọdịnaya nke metabolite nọ n'ọrụ bụ otu ihe ahụ. Ihe ego egosiputara di iche na ogwu adighi adighi mkpa oria ya.

Etu ị ga - esi mee ya, oleekwa ụdị usoro onunu ogwu a

A na - eji "Lozarel", ntuziaka maka ojiji nke kọwaa usoro kachasị mma maka usoro ọrịa dị iche iche, n'agbanyeghị nri. Mbadamba ahụ na-a drunkụbiga mmanya otu oge otu ugboro n’ụbọchị a ga-eme ka dọkịta kwoo.

Site n'ọbara mgbali elu (ọbara mgbali na-ebili elu karịa 140/90 mm Hg), a na-a medicationụ ọgwụ ahụ na 50 mg kwa ụbọchị. Dabere na njiri mara, usoro ịba ụba amụbaala ruru 100 mg. Site na belata BCC, ọgwụgwọ nke ọbara mgbali elu malitere 25 mg. Kedu ụdị ọbara ọbara na-egosi, n'ọrịa ọ bụla dọkịta kpebiri.

A na-agwọ nkụda mmụọ dịka otu atụmatụ. Usoro ọgwụgwọ na-amalite site na ọgwụ ọgwụ 12.5 mg kwa ụbọchị. Kwa izu, a na-amụba okpukpu abụọ: 25, 50, 100 mg. Ọ bụrụ na ọ dị mkpa, ịnwere ike ịnweta 150 mg nke "Lozarel" kwa ụbọchị.

Na ọrịa nephropathy na-eso ụdị ọrịa shuga II, ndị ọrịa na-ewere 50 mg ọgwụ ahụ kwa ụbọchị. Ọ ga-ekwe omume ịbawanye ọgwụ a na ọnụọgụ 100 mg. Otu atụmatụ ahụ dị mkpa maka ndị ọrịa nwere ọbara mgbali elu ventricular.

Dị Mkpa! Maka ndị ọrịa meworo agadi (karịa afọ 75), ndị ọrịa nwere ọrịa dị iche iche nke imeju ma ọ bụ akụrụ, usoro ọgwụgwọ ọgwụgwọ dọkịta site na ntuzi aka belata usoro ubochi kwa ụbọchị.

Mmekorita

Nchikota "Lozarel" na NSAIDs nwere ike ibute odida akụrụ. A na-ebelata ịdị irè nke ọgwụ ọgwụ mgbochi.

Njikọ ya na ọgwụ ndị nwere lithium na-akpata mmụba na lithium plasma.

Mkpụrụ ọgwụ a na-enweta n’ọkụ n’ọkụ na “lozarel” nwere ike ịkpalite ọrịa hyperkalemia.

Ọgwụ a na - akwalite mmetụta na ahụ nke ọgwụ ọgwụ antihypertensive. Mgbe ị na-edepụta "Lozarel" ya na ndị na-egbochi ATP, ọ dị mkpa ka ị na-enyocha ọnọdụ akụrụ oge niile, ebe ọ bụ na ohere nke mmeghachi omume ọjọọ na-abawanye nke ọma.

Enwere ike dochie "Lozarel" na ọgwụ ọzọ nwere ụdị mmetụta a. Omumaatu:

Ọgwụ dịgasị iche na ọnụ ahịa yana onye nrụpụta. Mana ịkwesighi ịgbanwe “Lozarel” nke dọkịta gị depụtara maka ọgwụgwọ ọzọ. Ekwesịrị ịhọpụta analọg onye ọkachamara nke na-enyocha ọnọdụ ahụike nke onye ọrịa yana ogo ịgwọ ọgwụ na nke ọ bụla.

Lozarel, ntuziaka maka ojiji: usoro na usoro onunu ogwu

Miri mbadamba Lozarel ka a na-ewere ọnụ nye ọnụ, n'agbanyeghị nri ahụ.

• ọbara mgbali: usoro mbido na mmezi - 50 mg otu ugboro n'ụbọchị. N’ebe enweghị mmetụta ọgwụgwọ zuru ezu na ụfọdụ ndị ọrịa, a na-anabata mmụba nke ọgwụ ruru 100 mg, na nke a, a na-ewere mbadamba 1 ma ọ bụ ugboro abụọ kwa ụbọchị. Site na ọgwụgwọ concomitant na oke ọnụọgụ nke diuretics, iji Lozarel kwesịrị ịmalite na 25 mg (1/2 mbadamba) otu ugboro n'ụbọchị.
• ọrịa obi na-adịghị ala ala: mkpụrụ ọgwụ mbụ bụ 12.5 mg (1/4 mbadamba) 1 oge kwa ụbọchị, ụbọchị 7 ọ bụla na-abawanye ọgwụ ahụ ugboro abụọ, jiri nwayọ na-abawanye ya na 50 mg kwa ụbọchị, nyere nnabata ọgwụ ahụ.
• ụdị shuga mellitus nke 2 na proteinuria (iji belata ihe ize ndụ nke ịmalite hypercreatininemia na proteinuria): ọgwụ mbụ bụ 50 mg otu ugboro n'ụbọchị. Dabere na ubara mgbali ọbara n'oge ọgwụgwọ, enwere ike ịbawanye dose ahụ ruo 100 mg na 1 ma ọ bụ usoro onunu ogwu,
• ọbara mgbali ọbara na ndị ọrịa nwere mgbali ventricular hypertrophy (na-ebelata ihe ọghọm nke ibute ọrịa obi na onwu): ihe mbido bụ 50 mg otu ugboro n’ụbọchị, ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ya na 100 mg.

Maka ndị ọrịa nwere nsogbu akụrụngwa ezighi ezi (CC na-erughị 20 ml / min), akụkọ banyere ọrịa imeju, akpịrị ịkpọ nkụ, karịa afọ 75 ma ọ bụ n'oge usoro ọgwụgwọ, a ga-edekọ ọgwụ Lozarel nke mbụ kwa ụbọchị na ọnụọgụ 25 mg (1/2 mbadamba).

Na arụ ọrụ ezumike ọrụ

Ekwesịrị igosipụta nlezianya na ọgwụgwọ nke ndị ọrịa nwere akwara gbasara akwara, isi ihe na-emetụta akwara akwara, stenosis nke akwara akụrụ.

Gwọ usoro akwadoro maka ọrụ mkpado na-arụ ọrụ (CC erughi 20 ml / min): mbido mbụ - 25 mg (1/2 mbadamba) otu ugboro n'ụbọchị.

Nyocha na Lozarel

Nyocha banyere ndị ọrịa Lozarel na ndị ọkachamara dị mma. Ndị dọkịta chọpụtara na ọgwụ ahụ, na mgbakwunye na usoro antihypertensive, nwere mmetụta diuretic ọzọ. Mbanye Lozarel na-eme ka nsogbu ahụ kwụsị, ọ na-egbochi mmalite na mmepe nke ọbara mgbali myocardial. Na nkụda obi na-adịghị ala ala, ikike iguzogide mmega ahụ na-abawanye.

N'ime ndị ọrịa nwere ọrịa mellitus na nephropathy, ị Loụ Lozarel na-ahụ maka mwepụ nke edema.