Lisinoton® (Lisinoton®)

Mpempe usoro onunu ogwu - mbadamba (pcs iri. N’ime panyo oyuyo, 3 blisters n’ime kaadiboodu, pọọki 14. N’ime ngwugwu ogbe, iko dị abụọ n’ime kaadiboodu, mkpọ nke ọ bụla nwekwara ntuziaka maka iji Lysinotone):

• onunu ogwu nke 5 mg: okirikiri, dị larịị, ọcha, nke nwere ihe egwu n'akụkụ abụọ,
• usoro onunu ogwu nke 10 mg: gburugburu, biconvex, pink dị na agba (ikekwe ụcha marbling), na nsogbu,
• onunu ogwu nke 20 mg: okirikiri, biconvex, pink (o nwere ike ibute ahihia), nwere nsogbu.

Ngwakọta 1 mbadamba:

• ihe na-arụ ọrụ: lisinopril (n'ụdị mmiri mmiri) - 5, 10 ma ọ bụ 20 mg,
• ihe inyeaka: silium croscarmellose, calcium hydrogen phosphate dihydrate, magnesium stearate, mannitol, ọka ọka pregelatinized. Mpempe mkpụrụ 10 mg nwekwara ngwakọta nke na-acha pink pink PB-24823, mbadamba 20 mg nwere ngwakọta na-acha pink pink PB-24824.

Mlọ ọgwụ

Ngwurugwu ọrụ nke lisinotone - lisinopril, bụ ihe mgbochi ACE. A kọwara usoro nke mmetụta ya n’arụ site na ikike iji belata nguzobe nke angiotensin II angiotensin II, nke na-eduga n’ibelata na mwepụta nke aldosterone. Effectsfọdụ mmetụta nke ọgwụ ahụ bụ n'ihi nsonaazụ ya na sistemụ renin-angiotensin anụ ahụ.

Lisinopril na-ebelata mbibi nke bradykinin, na-eme ka njikọ nke prostaglandins dịkwuo elu. Ọ na-eme ka akwara akwara dị elu karịa akwara. Na-ebelata ọbara mgbali (BP), ngụkọta akwara olu (OPSS), mgbali elu nke akwara nke mbu. Na-eme ka ọ̀tụ̀tụ̀ ọbara ji erugharị na ntachi obi myocardial nwee nchegbu n'ime ndị ọrịa nwere nkụchi obi na-adịghị ala ala.

Site na usoro ọgwụgwọ ogologo oge, lisinopril na-eme ka ọkọnọ ọbara ọbara nke isyomic myocardium belata, na-ebelata ọbara mgbali nke myocardium na mgbidi nke akwara ndị dị n'ụdị resistive.

Lysinotone na-eme ka ogologo ndụ nọrọ na ndị ọrịa nwere nkụda mmụọ na-adịghị ala ala, na-emekwa ka ọsịganụ nke njọ ventricular dysfunction na ndị ọrịa mgbe myocardial infarction na enweghị ọnya ngosipụta nke ahụike obi.

Mgbe otu Lysinotone na-agbaso, mmetụta hypotensive na-amalite mgbe elekere 1 gachara, rute oke n'ime awa 6, na-adịgide ruo awa 24. Ogologo nsonaazụ ahụ dabakwara na oke ọgwụ. Site n'ọbara mgbali elu, nsonazụ ahụ gosipụtara onwe ya n’ụbọchị mbụ mgbe mmalite ọgwụgwọ, mmetụta kwụsiri ike na-amalite mgbe ọnwa 1-2 gachara.

N'ihe banyere mwepu nke Lysinotone na mberede, egotabeghị mmụba nke ọbara mgbali elu.

Lisinopril na-ebelata albuminuria. Na-arịa hyperglycemia, ọ na-enyere aka rụọ ọrụ nke endothelium glomerular mebiri emebi. Ọ nweghị mmetụta ọ bụla na ọkwa nke glucose n'ọbara nke ndị ọrịa nwere ọrịa mellitus, n'otu n'otu, abụghị ihe kpatara mmụba na ngosipụta nke hypoglycemia.

Mlọ ọgwụ

Ozugbo n'ime eriri afọ, a na-etinye lisinopril n’ihe dị ka 30%. Iri nri anaghị emetụta ogo nnabata nke lysinotone.

Bioavailability bụ 29%. A na-erute itinye uche kacha elu n'ime awa 7 wee bụrụ 90 ng / ml.

Lisinopril ihe fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Na-agafe ụbụrụ ọbara na ihe mgbochi placental na mkpo ala.

Ọ bụghị biotransformed. Ọ bụ akụrụ na-agbanweghi agbanwe. Oge iwepu ọkara ndụ bụ awa iri na abụọ.

Ihe ngosi maka ojiji

• ọgwụgwọ nke nnukwu ọrịa myocardial infarction na paradaịs hemodynamic kwụsiri ike n'oge mbụ - iji nwee ike ịbelata oke ọcha ma gbochie mmepe nke dysfunction ekpe na nkụda obi.
• monotherapy ma ọ bụ ọgwụgwọ ọgwụgwọ nke ọbara mgbali elu,
• ngwakọta ọgwụgwọ nke nkụda obi na-adịghị ala ala (yana mgbakwunye na diuretics na / ma ọ bụ nhazi digitalis).

Ihe ngbanwe

• isi nkọlọ nke Quincke,
• akụkọ banyere ọrịa anioedema (n'agbanyeghị ihe kpatara ya),
• afọ ruo afọ 18
• ime na lactation
• hypersensitivity na mpaghara ọ bụla nke ọgwụ ma ọ bụ ndị ọzọ na-egbochi ACE.

Ejiri mbadamba nkume Lysinotone jiri usoro ndị a:

• nnukwu nsogbu gbasara akụrụ, nsogbu akụrụ, stenosis nke otu akụrụ ya na akwara ozi na-aga n'ihu ma ọ bụ akwara azụ akwara, ọnọdụ mgbe akụrụ gbasara akụrụ,
• azotemia, hyperkalemia,
• Ọnọdụ hypovolemic (gụnyere n'ihi afọ ọsịsa ma ọ bụ vomiting),
• mgbochi nke ụmị ọkpụkpụ,
• ọrịa obi, akwara ọbara, hypotrophic obstructive cardiomyopathy, stenosis nke aortic orifice, coronary insufficiency,
• hyperaldosteronism,
• ọrịa autoimmune systemic nke anụ ahụ na - ejikọta ya (gụnyere scleroderma na system lupus erythematosus),
• Ọrịa ụbụrụ (gụnyere ụbụrụ nke ụbụrụ),
• nká
• na-arapara n'ihe oriri nke nwere sodium pere mpe.

Lisinoton, ntuziaka maka ojiji: usoro na usoro onunu ogwu

Ekwuru mbadamba nkume Lysinotone maka nchịkwa ọnụ.

Site na ọbara mgbali elu, dị ka otu ọgwụ, a na-enye Lysinoton ọgwụ 5 ugboro otu ugboro n'ụbọchị. Ọ bụrụ na mmetụta hypotensive ezughi oke, a na-abawanye ọgwụ ahụ site na 5 mg kwa ụbọchị 2-3 ruo mgbe arụpụtara nsonaazụ achọrọ, mana ọ bụghị ihe karịrị 40 mg kwa ụbọchị (mmụba ọzọ na dose ahụ anaghị ebute mbelata ọbara dị elu). Usoro nlekọta kwa ụbọchị bụ 20 mg. Nsonaazụ zuru oke na-etolite mgbe izu 2–4 nke ọgwụgwọ gasịrị, nke a ga-enyocha ya n'oge oge ịtụle. Ọ bụrụ ọbụlagodi mgbe ị theụchara ọgwụ kwa ụbọchị, ọbara mgbali anaghị adalata nke ọma, gwa ọgwụ ngwakọta.

A ga-akagbu ndị ọrịa natara ọgwụ dijeri ụbọchị abụọ tupu mmalite ị ofụ Lysinotone. Ọ bụrụ na nke a agaghị ekwe omume, ọgwụ mbụ nke lisinopril kwesịrị ịbụ 5 mg. N'ime awa ole na ole (ihe dị ka awa 6) mgbe ọ takingụsịrị ọgwụ nke mbụ, dọkịta kwesịrị ilebara onye ọrịa ahụ anya nke ọma nke ga-enyocha usoro iji belata ọbara mgbali elu (iji gbochie mbupute mgbali elu).

N'ihe banyere ọbara ọgbụgba mgbagha na ọnọdụ ndị ọzọ na ọrụ na-arịwanye elu nke sistemụ renin-angiotensin-aldosterone (RAAS), a na-atụ aro ịmalite ịmalite Lisinoton n'okpuru nlekọta nke dọkịta (nyochaa ọbara mgbali, ọrụ akụrụ na ịta ọka potassium) na obere mmalite mbụ - 2.5-5 mg kwa ụbọchị. A na-ekpebi ogo mmezi sitere na nsonaazụ nke ike nke wedata ọbara mgbali elu.

N'ime ndị ọrịa nwere akụrụ gbasara akwara, a na-ekpebi ụzọ ọgwụ mbụ nke Lysinotone dabere na nhichapụ ikike creatinine (CC). A na-edobere mmezi ahụ dabere ogo nke nsonaazụ n'okpuru nleba anya mgbe niile gbasara ọrụ akụrụ yana ịta ọka potassium.

Usoro a tụrụ aro ka amalite maka ndị ọrịa nwere ọdịda akụrụngwa:

• KK 30-70 ml / min - 5-10 mg,
• KK 10-30 ml / min - 2.5-5 mg,
• QC

Ngwakọta na ụdị ntọhapụ

na ngwugwu bliri nke 10 ma ọ bụ 14 PC, na ngwugwu kaadiboodu 3 ma ọ bụ 2, n'otu n'otu.

na ngwugwu bliri nke 10 ma ọ bụ 14 PC, na ngwugwu kaadiboodu 3 ma ọ bụ 2, n'otu n'otu.

na ngwugwu bliri nke 10 ma ọ bụ 14 PC, na ngwugwu kaadiboodu 3 ma ọ bụ 2, n'otu n'otu.

Nkọwa nke ụdị usoro onunu ogwu

5 mg mbadamba: okirikiri, biconvex mbadamba, na notch, na-acha ọcha.

10 mg mbadamba: okirikiri, mbadamba biconvex, nwere ọchichiri, pink dị ọkụ.

Mbadamba 20 mg: gburugburu, mbadamba biconvex, nwere ọkwa, pink, marbling ka ekwe.

Ngosipụta nke ogwu Lysinoton ®

Ọbara mgbali elu (na monotherapy ma ọ bụ ijikọ ya na ndị ọzọ na - ahụ maka ọgwụ mgbochi), nkụda obi na - adịghị ala ala (dịka akụkụ nke ọgwụgwọ njikọta maka ndị ọrịa na - ewere digitalis na / ma ọ bụ diuretics), ọgwụgwọ oge mbụ nke nnukwu myocardial infarction (na awa iri abụọ na anọ mbụ na - enwe ezigbo hemodynamics maka maintachekwa ihe ndị a ma gbochie nkụda mmụọ na nkụchi obi.

Ime na lactation

Ihe lisinopril na-eme n’oge ime di ime. Mgbe etinyere ime, ekwesịrị ịkwụsị ọgwụ a ozugbo enwere ike. Nnabata nke ndị na - egbochi ACE na oge nke atọ na nke atọ nke afọ ime nwere mmetụta dị njọ na nwa ebu n’afọ (mbelata ọbara mgbali, ọdịda akụrụ, hyperkalemia, hypoplasia cranial, ọnwụ intrauterine). Enweghị data na mmetụta ọjọọ nke ọgwụ ọjọọ na nwa ebu n'afọ ma ọ bụrụ na ejiri ya n'oge ọnwa atọ. Maka ụmụ amụrụ ọhụrụ na ụmụ aka amụrụ ihe na-ebute intrauterine n’ebe ndị na-egbochi ACE, a na-atụ aro ka ejiri nlezianya nyochaa anya oge ịchọpụta mbelata ọbara mgbali elu, oliguria, hyperkalemia. Lisinopril na-agafe Plasenta. Enweghị data na ntopute nke lisinopril n'ime mmiri ara. Ruo oge ọgwụgwọ ọgwụ ahụ, ọ dị mkpa ịkagbu ara.

Nsonaazụ

Nsonaazụ ndị kachasị emetụta bụ ọgbụgbọ, isi ọwụwa (na 5-6% nke ndị ọrịa), adịghị ike, afọ ọsịsa, ụkwara akọrọ (3%), ọgbụgbọ, ọgbụgbọ, hyperension orthostatic, ọnya anụ ahụ, obi mgbu (1-3%).

Nsonaazụ ndị ọzọ (ugboro ole nke ọbara mgbali elu, orthostatic hypotension, ọrụ ezughi oke ọrụ.

Site n'akụkụ nke usoro ụjọ ahụ: ike ọgwụgwụ, ura, agbagọ akwara nke ukwu aka na egbugbere ọnụ.

Site na sistemụ hemopoietic: leukopenia, neutropenia, agranulocytosis, thrombocytopenia ga-ekwe omume, na ọgwụgwọ ogologo oge - ntakịrị mbelata na ịba ọcha n'anya na hematocrit, erythrocytopenia.

Nnyocha ụlọ nyocha: hyperkalemia, azotemia, hyperuricemia, hyperbilirubinemia, ịba ụba nke enzymes "imeju", ọkachasị ma ọ bụrụ na enwere akụkọ banyere ọrịa akụrụ, ọrịa shuga mellitus na ọbara mgbali ala.

Ọrịa a na-enwekarị nsogbu:

Si usoro obi: ọrịa palpitations, tachycardia, infarction myocardial, ọrịa strokrovaskụla ọrịa obi na ọrịa nwere oke ọrịa, n'ihi mbelata ọbara mgbali elu.

Site na ngwara: akpọnwụ akpịrị, anorexia, dyspepsia, mgbanwe uto, afọ mgbu, pancreatitis, hepatocellular ma ọ bụ cholestatic jaundice, ịba ọcha n'anya.

Na akpukpo ahu: urticaria, sweating, akpụkpọ itching, alopecia.

Site na urinary system: adịghị arụ ọrụ ezumike, oliguria, anuria, nnukwu gbasara akụrụ, uremia, proteinuria.

Site n'akụkụ nke usoro ụjọ ahụ: ọrịa asthenic syndrome, ike ọgwụgwụ nke ọnọdụ, ọgba aghara.

Ndị ọzọ: myalgia, ahụ ọkụ, nsogbu nke nwa ebu n’afọ, nwere obere mbelata.

Mmekorita

Ọ dị mkpa ịkpachara anya mgbe ị na-eji ọgwụ ahụ ọgwụ na-enye ọgwụ ọgwụ na-akpata ọgwụ (spironolactone, triamteren, amiloride), potassium, nnu nke nwere potassium (ihe ize ndụ nke ịmalite hyperkalemia na-abawanye, ọkachasị na ọrụ ezigharị arụ ọrụ, ya mere, enwere ike ịkọ ha ọnụ naanị na ndabere nke mkpebi otu onye dọkịta na-enwe mgbe niile. Nyochaa ọkwa potassium na ọrụ akụrụ).

Enwere ike itinye mgbakwunye ọnụ:

- ya na diuretics: ya na njikwa ọzọ nke diuretic na onye ọrịa na - ewere Lisinoton, dịka iwu, mmetụta antihypertensive na - apụta - ihe egwu nke mbelata ọbara mgbali elu. Lisinopril na -ebelata ntụpọ nke potassium site n'ahụ ahụ n'oge ọgwụgwọ ya

- na ihe ndị ọzọ na - eme ihe na - egbochi ihe (uto)

- na NSAIDs (indomethacin, wdg), estrogens, yana adrenostimulants - mbelata mmetụta antihypertensive nke lisinopril,

- na lithium (ikuku lithium nwere ike ibelata, yabụ, a ga-enyocha nlebara lithium anya),

- na antacids na colestyramine - belata mmụcha ahụ na ngụkọ nri.

Mmanya na-abawanye nsonaazụ nke ọgwụ.

Usoro onunu ogwu na nhazi

N'ime. Site n'ọbara mgbali elu, ndị ọrịa na-anabataghị ọgwụ mgbochi ọgwụ ọzọ ka etinyere 5 mg otu ugboro n'ụbọchị. Na enweghị mmetụta, a na-abawanye ọgwụ ahụ kwa ụbọchị 2-3 site na 5 mg gaa na nkezi ọgwụgwọ 20-40 mg / ụbọchị (ịba ụba dose ahụ karịa 40 mg / ụbọchị anaghị ebute mgbadawanye n'ọbara.) Ihe a na-ahụkarị kwa ụbọchị bụ 20 mg. Oke kachasị kwa ụbọchị bụ 40 mg.

Nsonaazụ zuru oke na-etolite mgbe izu 2-4 site na nmalite ọgwụgwọ, nke ekwesiri iburu n'uche mgbe ị na-abawanye dose ahụ. Site na nsonaazụ na-ezighi ezi nke ụlọ ọgwụ, ọ ga-ekwe omume ijikọta ọgwụ na ọgwụ ndị ọzọ antihypertensive.

Ọ bụrụ na onye ọrịa ahụ natara ọgwụgwọ mbido site n’ọrịa diuretics, mgbe ahụ, a ga-akwụsị ị intụ ọgwụ ndị ahụ ụbọchị 2-3 tupu mmalite nke nchịkwa Lysinotone. Ọ bụrụ na nke a agaghị ekwe omume, mgbe ahụ ọgwụ mbụ nke Lysinotone ekwesịghị gafere 5 mg / ụbọchị. N'okwu a, mgbe ị takingụsịrị ọgwụ nke mbụ, a na-atụ aro ịlele ahụike maka ọtụtụ awa (a na-enweta nsonaazụ kachasị mgbe ihe dị ka awa 6), n'ihi mbelata ọbara mgbali elu nwere ike ịda.

Na Ọrịa Renovascular ma ọ bụ ọnọdụ ndị ọzọ na ọrụ na-abawanye nke sistemụ renin-angiotensin-aldosterone, ọ dịkwa mma ịkọwapụta ọgwụ mmalite dị ala nke 2.5-5 mg kwa ụbọchị, na nlekọta nlekọta ahụike (njikwa ọbara mgbali elu, ọrụ akụrụ, ịta ọka potassium). Ekwesịrị ịhọrọ usoro mmezi ahụ, na-aga n'ihu na nlekọta ahụike siri ike dabere na ogo nrụgide ọbara.

Na okukpu okpu n'ihi eziokwu ahụ bụ na a na-ahụpụta akwara lisinopril site na akụrụ, a ga-ekpebi ọgwụ izizi dabere na nhichapụ nke creatinine, mgbe ahụ, na mmeghachi omume ya, ekwesịrị ịkwụ ụgwọ mmezi n'okpuru ọnọdụ nlebara anya ugboro ugboro maka ọrụ gbasara akụrụ, potassium, sodium na ọbara ọbara (gụnyere ndị ọrịa mesoo ya na hemodialysis).

Site na mgbali ọbara ike Ekwadoro ogologo oge ọgwụgwọ mmezi nke 10-15 mg / ụbọchị.

Na nkụda mmụọ obi na-adịghị ala ala - bido na 2,5 mg 1 oge kwa ụbọchị, nke na-esote mmụba nke 2.5 mg mgbe ụbọchị 3-5 gachara, na-akwado kwa ụbọchị nke 5-20 mg. Ọgwụ ahụ agaghị agafe 20 mg / ụbọchị.

N'ime ndị agadi, a na-ahụkarị mmetụta na-adịkarị elu ma na-adị ogologo oge, nke a na-ejikọ ọnụ na mgbakwunye nke lisinopril excretion (a na-atụ aro ịmalite ọgwụgwọ na 2.5 mg / ụbọchị).

Nnukwu myocardial infarction (dịka akụkụ nke ọgwụgwọ njikọta). N’ụbọchị mbụ - 5 mg n’ọnụ, emesia 5 mg kwa ụbọchị, 10 mg mgbe ụbọchị abụọ gachara, 10 mg otu ugboro n’ụbọchị. N'ime ndị ọrịa nwere nnukwu myocardial infarction, a ga-eji ọgwụ ahụ ọ dịkarịa ala izu isii.

Na nmalite ọgwụgwọ ma ọ bụ n’ime ụbọchị 3 mbụ mgbe ọ nwesịrị nnukwu myocardial infarction na ndị ọrịa nwere ọbara mgbali elu (120 mm Hg ma ọ bụ ihe na-erughị ya), a ga-atụ aro obere ọgwụ nke 2.5 mg. N'ihe banyere mbelata ọbara mgbali (SBP dị n'okpuru ma ọ bụ hara Hg nke 100 mm), kwa ụbọchị, 5 mg nwere ike, ma ọ bụrụ na ọ dị mkpa, belata obere oge ruo 2.5 mg.N'ihe banyere mbelata ọbara mgbatị ogologo oge (SBP dị n'okpuru 90 mm Hg. Art. Karịa elekere 1), a ga-akwụsị ịkwụsị ọgwụgwọ na Lisinoton.

Dodoụbiga ya ókè

Ọrịa (ime mgbe ị na-ewere otu ọgwụ nke 50 mg): mbelata nke pụtara ọbara mgbali elu, ọnụ akọrọ, iro ụra, njide urinary, afọ ntachi, nchekasị, oke iwe.

Ọgwụgwọ: usoro ọgwụgwọ symptomatic, nchịkwa mmiri iv, njikwa ọbara ọgbụgba, nguzo mmiri-electrolyte na normalization nke ndị ikpeazụ. Lysinotone nwere ike wepu ya site na hemodialysis.

Ntụziaka pụrụ iche

Hypotension Symptomatic. Ọtụtụ mgbe, mbelata ọbara mgbali elu pụtara na mbelata nke mmiri na-ebute site na ọgwụgwọ diuretic, mbelata nke oke nnu na nri, ọnya afọ, afọ ọsịsa, ma ọ bụ vomiting. N'ime ndị ọrịa nwere ọrịa obi na-adịghị ala ala nke nwere ezigbo akwara akwara ma ọ bụ na-enweghị ya, mbelata ọbara mgbali elu ga-ekwe omume. A na-ahụkarị ya na ndị ọrịa nwere nnukwu nkụda mmụọ nke obi na-adịghị ala ala, n'ihi ojiji nke nnukwu usoro ọgwụgwọ diuretics, hyponatremia, ma ọ bụ ọrụ na-arụ ọrụ na-arụ ọrụ nke ukwuu. N'ime ndị ọrịa dị otú ahụ, ekwesịrị ịmalite ọgwụgwọ na Lisinotone n'okpuru nlezianya nke dibịa (jiri nlezianya họrọ nhọrọ nke ọgwụ na diuretics). Ekwesịrị ịgbaso iwu ndị yiri ya mgbe ị na-edepụta ndị ọrịa nwere ọrịa obi na akwara ụbụrụ yana ụkọ nri ụbụrụ, na oke mbelata ọbara mgbali elu nwere ike ibute infarction myocardial ma ọ bụ ọrịa strok. Mmeghachi azụ hypotensive abụghị ọgwụ mgbochi maka ị theụ ọgwụ ọzọ. Mgbe ị na-eji Lysinotone na ụfọdụ ndị ọrịa nwere nkụda mmụọ na-adịghị ala ala, mana iji ọbara mgbali nkịtị ma ọ bụ nke dị ala, mbelata ọbara mgbali nwere ike ime, nke na-abụkarị ihe kpatara ịkwụsị ọgwụgwọ. Tupu ịmalite ọgwụgwọ na Lysinotone, ọ bụrụ na ọ ga - ekwe omume, mee ka mkpesa sodium na / ma ọ bụ mejupụta mmiri nke furu efu, nyochaa anya mmetụta mbụ nke Lysinotone na onye ọrịa. N'ihe banyere stenosis nke akwara gbasara akụrụngwa (ọkachasị ma ọ bụrụ na ọgbụgba, ma ọ bụ ọnụnọ nke akụrụ), yana n'ihe gbasara okirikiri n'ihi sodium na / ma ọ bụ mmiri, ojiji nke Lysinotone nwere ike ibute ọrụ akwara na-adịghị mma, nnukwu akụrụ nke akwara, nke na-abụkarị A gaghị atụgharị ya ma ịkwụsị ọgwụ ahụ.

Na nnukwu myocardial infarction. Egosipụtara iji usoro ọgwụgwọ (thrombolytics, acetylsalicylic acid, beta-blockers). Enwere ike iji Lysinotone mee ihe na ntinye / ntinye ya ma ọ bụ iji usoro ọgwụgwọ transdermal nke nitroglycerin.

Ntinye aka ịwa ahụ / ọgwụ na-akụnwụ ahụ. Site na usoro ịwa ahụ dị ukwuu, yana iji ọgwụ ndị ọzọ na-eme ka ọbara mgbali elu na-ebelata, lisinopril, na-egbochi oruru nke angiotensin II, nwere ike ime ka akpọlata mbelata ọbara mgbali elu.

N'ime ndị ọrịa agadi otu uzo ahụ na-eduga n'ọtụtụ ọgwụ dị elu n'ọbara, yabụ, achọrọ nlekọta pụrụ iche mgbe ị na-ekpebi dose ahụ, n'agbanyeghị eziokwu adịghị ọdịiche na mmetụta antihypertensive nke Lysinotone n'etiti ndị agadi na ndị na-eto eto. Ebe ọ bụ na enweghị ike iwepụ ihe ize ndụ nke agranulocytosis, a chọrọ nlebara anya oge ihe osise ọbara. Mgbe ị na-eji ọgwụ ahụ eme ihe n’ọnọdụ ọnọdụ akụrụngwa na membrane polyacrylonitrile, ujo anaphylactic nwere ike ime, yabụ, a na-atụ aro ka ụdị ụdị akpụkpọ ahụ dị iche iche wee dialysis, ma ọ bụ nhọpụta ndị nnọchi anya antihypertensive ndị ọzọ.

Enweghị data na nsonaazụ nke lisinopril, etinyere na usoro ọgwụgwọ, na ikike ịkwọ ụgbọala na usoro, agbanyeghị, ekwesịrị iburu n'uche na ọgbụgba ga-ekwe omume, yabụ ekwesịrị ịkpachara anya.

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

Mbadamba ụrọ ndị ahụ bụ okirikiri, biconvex, pink dị na agba, nwere njikwa, yana dayameta nke 7 mm.

Ndị e mere: mannitol, calcium phosphate disubstituted dihydrate, ọka ọka pregelatinized, shịm croscarmellose, magnesium stearate, mmiri (E172).

10 PC - blisters (2) - ngwugwu nke kaadiboodu.
14 pi. - blisters (2) - ngwugwu nke kaadiboodu.

Omume ọgwụ

Ihe mgbochi ACE bụ polypeptidase nke na-egbochi ntụgharị nke angiotensin I na angiotensin II. Angiotensin II na - akpata vasoconstriction ma na - akpali ihe nzuzo nke aldosterone.

Mwepu ACE na-ebute mmebi nke ọrụ vasoconstrictor na mbelata na nzuzo nke aldosterone. N'ihi ya, ntakịrị mmụba na ọkwa potassium dị ka o kwere omume. N'ime ndị ọrịa nwere ọbara mgbali elu na arụ ọrụ akụrụ dịkarịsịrị ala, na-anata naanị lisinopril ruo ihe karịrị izu iri abụọ na anọ, nkezi mmụba na potassium serum dị ihe dị ka 0.1 meq / L. Agbanyeghị, ihe dị ka 15% nke ndị ọrịa gosipụtara mmụba nke ihe karịrị 0,5 meq / l na ihe dị ka 6% gosipụtara mbelata ihe karịrị 0,5 meq / l. N'otu ọmụmụ ụlọ ọgwụ ahụ, ndị ọrịa na-anata lisinopril na hydrochlorothiazide ruo ihe karịrị izu iri abụọ na anọ gosipụtara mbelata nke ogo surukaum nke 0.1 meq / l, ihe dịka 4% n'ime ha gosipụtara mmụba nke ihe karịrị 0,5 meq / l, na ihe dịka 1.2% mbelata ihe kariri 0,5 meq / l.

ACE bụ ihe jikọrọ kininase, enzyme nke na-ebibi bradykinin. Ọrụ nke bradykinin dị elu (ya na akụrụngwa vasodilating akpọpụtara) n'oge ọgwụgwọ na lisinopril aghọtachaghị, ọ chọkwara ịmụkwu ihe. N'agbanyeghị eziokwu ahụ bụ na usoro iji wedata ọbara mgbali elu n'oge ọgwụgwọ na lisinopril bụ ihe kachasị n'ihi mgbochi nke usoro renin-angiotensin-aldosterone, lisinopril nwekwara mmetụta hypotensive na ndị ọrịa nwere ọbara mgbali elu na ala nke renin. Ọ bụ ezie na lisinopril nwere mmetụta antihypertensive na ndị ọrịa nke agbụrụ niile, ndị ọrịa nwere ọbara mgbali elu - ndị nnọchite nke agbụrụ ojii (a na-eji ọnụ ọgụgụ dị ala nke renin) gosipụta azịza dị ala na monotherapy karịa ndị ọrịa so na agbụrụ ndị ọzọ. Ojiji nke lisinopril na hydrochlorothiazide na-ebelata ọbara mgbali na ndị ọrịa - ndị nnọchianya nke ndị isi ojii na agbụrụ ndị ọzọ, n'ihi nke ọdịiche dị na mmetụta antihypertensive n'ihi njirimara agbụrụ.

Ojiji nke lisinopril maka ọbara mgbali elu na-akpata mbelata ọbara mgbali ọ fọrọ nke nta ka ọ bụrụ n'otu oge ahụ na ọnọdụ supine na iguzo, na-enweghị na-akpata tachycardia na-akwụ ụgwọ. A na-ahụtakarị mmeghachi omume Orthostatic, ọ bụ ezie na ihe omume ha ga-ekwe omume, ọkachasị na mmiri na-egbu mmiri ma ọ bụ n'iwelata. Mgbe ejikọtara ya na ihe ọmụmụ thiazide, a na-ekwupụta mmetụta antihypertensive nke ọgwụ ndị ahụ.

N'ime ọtụtụ ndị ọrịa, a na-ahụ mmalite nke ọgwụ antihypertensive 1 awa mgbe nchịkwa ọnụ nke ọgwụ na otu ọgwụ, mmetụta kachasị na-apụta mgbe ihe dị ka awa 7. Mmetụta antihypertensive na-adịgide ruo awa 24 mgbe ị takingụ ọgwụ ahụ kwa ụbọchị. Dabere na ụfọdụ ọmụmụ, na nkezi, mmetụta a na-adịgide adịgide ma na-ekwupụta nke ukwuu mgbe ị na-a theụ ọgwụ ahụ na doses nke 20 mg ma ọ bụ karịa karịa mgbe ị na-ewere ya na obere usoro. Agbanyeghị, na nyochachara usoro ọmụmụ niile, mmetụta antihypertensive mmetụta dị ala na-adịwanye ike ka awa 24 ka nchịkwa gasịrị karịa ka ọ gachara 6 awa.

N'ime ụfọdụ ndị ọrịa, iji mepụta mbelata ọbara dị mma, ọ nwere ike ịdị mkpa ị takeụ ọgwụ ahụ mgbe niile maka izu 2-4.

Mmetụta antihypertensive nke lisinopril anaghị belata n’oge usoro ọgwụgwọ ogologo oge. Mwepu ọgwụ mberede na mberede anaghị ebute mmụba ọbara ma ọ bụ mmụba dị ukwuu (ma e jiri ya tụnyere ọbara mgbali tupu usoro ọgwụgwọ).

Mbelata ọbara mgbali elu na-apụta ngwa ngwa ma na-akpọpụtakwa ya karịa mgbe ị na-a theụ ọgwụ ahụ elu.

Ọdịdị nke lisinopril na mmeghachi omume ya na-emetụta ma ndị ọrịa na-eto eto ma ndị agadi.

Usoro usoro onunu ogwu

Site n'ọbara mgbali elu, ọgwụ mbụ nke ọgwụ maka ndị ọrịa na-enwetabeghị ọgwụ ndị ọzọ na-egbochi ha bụ 5 mg 1 oge / ụbọchị n'ụtụtụ. N'ọdịnihu, dabere na nsonaazụ ọbara ọgbụgba, usoro onunu ogwu maka ọgwụgwọ mmezi bụ 10-20 mg 1 oge / ụbọchị. Enwere ike imepụta ezigbo antihypertensive mmetụta mgbe izu 2-4 gachara site na mbido ọgwụ. Thebawanye usoro nke ihe kariri 40 mg / ụbọchị anaghị ebutekarị mmụba na nsonaazụ ahụ. N'okwu a, a na-atụ aro ọgwụgwọ ngwakọta na ntinye ọzọ nke diuretic na obere ọgwụ (wee nweta mmezi nke ihe). Oke kachasị kwa ụbọchị ekwesịghị ịkarị 80 mg. N'ime ndị ọrịa natara ọgwụ diuretics, ha ga-akagbu ụbọchị 2-3 tupu mmalite nke iji lisinotone. Ọgwụ mbụ kwa ụbọchị na n'ọnọdụ ndị a ekwesịghị ịfe karịa 5 mg / ụbọchị. Mgbe ị theụchara ọgwụ nke mbụ, a na-atụ aro ịgwọ ọrịa ruo mgbe a ga-enweta nkwụsi ike nke ọbara mgbali elu.

Na nkụchi obi, a na-eji ọgwụ ahụ eme ihe dị ka akụkụ nke usoro ọgwụgwọ siri ike n'otu oge na diuretics na / ma ọ bụ cardiac glycosides. Ọgwụ izizi nke Lysinotone bụ 2.5 mg / ụbọchị n'ụtụtụ, n'ọdịniihu ọ ga-eji nwayọ rute 5-10 mg 1 oge / ụbọchị. Oke kachasị kwa ụbọchị bụ 20 mg.

Maka ọgwụgwọ nke infarction na-arịa nnukwu myocardial, ekwesịrị iji lisinotone dị ka njikọta na usoro ọkọlọtọ (gụnyere yana iji ọgwụ nitptomatic). N'ime ndị ọrịa nwere ọrịa metụtara akwara ụkwụ, a pụrụ ịmalite ọgwụgwọ n'ime awa iri abụọ na anọ mbụ mmalite nke mgbaàmà nke nkụchi obi. Usoro izizi nke Lysinotone bụ 5 mg, mgbe ahụ 5 mg mgbe awa 24 gachara, 10 mg mgbe ọ dị awa iri anọ na asatọ, ma ọ bụ 10 mg / ụbọchị.

Maka ndị ọrịa nwere mgbali ọbara systolic dị ala (ihe na-erughị 120 mm Hg) na mmalite ọgwụgwọ ma ọ bụ n'ime ụbọchị 3 mbụ mgbe mmalite nke nkụchi obi, dose ahụ bụ 2.5 mg. Na ọnụnọ nke hypotension arterial (mgbali ọbara systolic n'okpuru 100 mm Hg), usoro mmezi kwa ụbọchị ekwesịghị gafere 5 mg na, ọ bụrụ na ọ dị mkpa, enwere ike belata 2.5 mg. Site na ọgbụgba akwara na-adịgide adịgide (mgbali ọbara systolic erughị 90 mm Hg maka ihe karịrị otu awa), a ga-akwụsị ịkwụsị ọgwụgwọ na lisinotone.

Ogologo oge ọgwụgwọ bụ izu isii. Obere mmezi kacha nta bụ 5 mg / ụbọchị. Ọ bụrụ na enwere ihe mgbaàmà nke nkụda obi, aga-aga n’ihu.

N'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa ezumike, a na-ekpebi dose ahụ dabere na QC.