Etu esi eji ọgwụ Durogezik? > Ọgwụgwọ na mgbochi

Usoro Durogezic nke nwere ebe nchekwa fentanyl ezubere maka ọgwụgwọ ogologo oge nke mgbu na-adịghị ala ala kachasị ndị ọrịa cancer. Mmetụta ndị bụ isi ihe mgbu na ogwuura. Fentanyl sịntetik na-emekọrịta ihe na ndị na-anabata opioid. Na-emebi iwu nnyefe nke oge na-egbu mgbu n'okporo ụzọ nke thalamus na hypothalamus. Ọ bụ ihe siri ike (ugboro 100) analgesic karịa morphine.

Oge ngụkọta nke kwachie elekere 72. Ọnụego ihe ewepụtara na sistemụ sistemụ na-esite na mpaghara kwachie ya bụ 25, 50, 75 ma ọ bụ 100 μg kwa elekere.

Na mgbakwunye, ọgwụ ahụ na-egbochi etiti iku ume, na-eme ka etiti vomiting wee dajụọ obi obi. Fọrọ nke nta ọ nweghị mmetụta ọ bụla na ọbara mgbali. Na-abawanye ụda sphincter, belata motility eriri afọ na usoro ọbara gbasara akwara. Na-akpata obi ụtọ ma na-akwalite mmalite nke ụra.

Mlọ ọgwụ

A na-ahapụ Fentanyl na ọnụego oge niile. Mgbe idechara ya, ihe mmụta plasma na-abawanye karịa awa iri abụọ na abụọ ruo iri abụọ na anọ, wee na-adịgide oge niile awa iri anọ na asatọ fọdụrụ Ọle ọ -bụru bụkota iwhe dụkota l'echilabọ. A na-akwado ịha nhatanha site na ngwa ugboro nke TTS nke otu nha.

Mgbe ewepụchara TTC, ịta ahụ ga-eji nwayọ belata. T1 / 2 bụ nkezi nke awa 17. Site nwayọ pụọ na plasma ọbara, ka nnabata nke fentanyl si anụ ahụ na-aga n'ihu. N’ebe ndị ọrịa dara ada, belata ka ewepụlata ma T1 / 2 gbasaa. Metabolism pụtara na imeju, akụrụ, eriri afọ. 75% nke ọgwụ na-abụba mmamịrị na mmamịrị, 9% na feces.

Ihe ngosi maka ojiji

mgbu kansa
ihe mgbu neuropathic (ya na polyneuropathy na-arịa ọrịa mamịrị, syringomyeliammerụ ahụ otutu sclerosis),
enwere mgbu ọrịa ogbu na nkwonkwo na ogbu na nkwonkwo.

Ihe ngbanwe

Mgbu postolowo
mmegbu nke etiti iku ume,
pseudomembranous colitismere ị takingụ ọgwụ nje (cephalosporins, penisilini, linksamides),
akpịrị na-egbu egbu,
tụụrụ ime
akpụkpọ ahụ mebiri emebi na saịtị ahụ,
afọ ruo afọ 18.

N'iji nlezianya dee ọgwụ a mgbe ụbụrụ ụbụrụ, ọrịa ngụgụ na-adịghị ala alaubara mgbali intracranial, mmerụ ahụ ụbụrụ, gbasara akwara na imeju imeju, ọrịa gallstone, hypothyroidism, hyperplasia prostaticọnọdụ dị oke njọ, warara nke urethra, alisụrụma, njiri chọrọ igbu onwe onye ọrịa, iwere insulin, MA inhibitors, GKSọgwụ antihypertensive.

Nsonaazụ

iro ụra ịda mba, hallucinations, nchekasị, isi ọwụwa, ọgba aghara, enweghị nke ọ bụla yuphoria, ehighi ura, amnesia, paresthesia,
hypoventilationume iku ume bronchospasm, mkpụkpu ume,
ọgbụgbọ afọ ntachi, biliary colicakpọọ nkụ obere oge afọ ọsịsa,
bradycardia ma obu tachycardia, ọbara mgbali elu ma obu hypotensionnjigide urinary
ịdabere na anụ ahụ na nke uche
mmeghachi omume mpaghara n'ụdị ihe ọkụ ọkụ, itching na hyperemiana - agafe otu ụbọchị mgbe mwepụ nke TTC gasịrị.

Bụrụ na ọ na-akwụsị akwụsị ọgwụgwọ na-amalite "Mwepu ọrịa": ọgbụgbọ, ọgbụgbọ, akpata oyi, afọ ọsịsa, ụjọ. Ọrịa a na-anaghị ekwupụta ma ọ bụrụ na-eji nwayọ belata nwayọ.

Durogezik, ntuziaka maka ojiji (Usoro na usoro onunu ogwu)

A na-etinye nkwado ịmachi Durogezik n'ụzọ, na-etinye aka na anụ ahụ nke anụ ahụ ma ọ bụ ogwe aka n'akụkụ nke elu. Ebe ahụ kwesịrị ịdị n ’ntutu dị ntakịrị, nke a na-egbutu tupu ngwa. Tupu itinye patch ahụ, akpụkpọ ahụ ga-abụrịrị nkụ, ejila ncha, mmanụ ma ọ bụ ude mmiri.

Nkwado a na-amịkọta ọnụ ozugbo ewepụrụ ya na ngwungwu ahụ, a na-eji aka gị agbagide ya ruo ebe a na-etinye ya maka sekọnd iri atọ. - Ihu kwesịrị dabara n'anụ akpụkpọ. Usoro ohuru ahụ na - glued na mpaghara ọzọ nke anụahụ. N'ime ndị ọrịa na-ewereghị opioids, ọgwụ dịkarịsịrị ala bụ 25 μg / h. Mgbe ị na-aga Nkwalite A na-ejikwa ọgwụ a. Mgbe ị na-agbanwe site na ọgwụ ọgwụ ọjọọ, a na-agbakọ mkpa nyocha kwa ụbọchị maka ọgwụ ọgwụ gara aga. Ọ bụ dọkịta ga-eme nhọpụta ndị a niile.

Mgbe ngwa nke mbụ gasịrị, ntinye uche nke ihe na-arụ ọrụ ji nwayọọ nwayọọ na-abawanye karịa awa iri na abụọ ruo iri na abụọ, ya mere, onye ọrịa chọrọ nyocha dị obere. Ọ bụrụ na n’ụbọchị nke atọ onye ọrịa ahụ ka chọkwuru ọgwụ mgbu, mgbe ahụ, a na-eme ka usoro ọgwụgwọ ọzọ nke TTC mụbaa site na 25 μg / h. Mgbe etinyere TTS, mkpokọta ọgwụ na-agbadata nwayọ, yabụ edepụtara ọgwụ opioids ndị ọzọ na mmụba nwayọ.

Matrix Durogezik N'adịghị ka pater reservoir, ọ jikọtara ọnụ - nrapado na fentanyl nwere. Yabụ na ọ dị aghụghọ karịa, ọ na-agbanwe agbanwe, akọwaghị ya ma dịkwa mma iji ya. Na mgbakwunye, ọ na-emeziwanye ihe nrapado. Ọnụnọ nke esite na fentanyl yana ngwakọta nke ihe eji arụ ọrụ na-eme ka nchekwa nke ọgwụ ahụ dịkwuo elu, ebe ọ bụ na patch mebiri, ịhapụ ọgwụ a na-achịkwaghị achịkwa na ịdoụbiga ya ókè agaghị ekwe omume. Ọ dị na nsụgharị dị iche iche nwere ikike dị iche iche. Mgbe ejiri ya na sistemu sistem, a na-ahapụ 12.5, 25, 50, 75 ma ọ bụ 100 μg nke ihe na-arụ ọrụ kwa elekere n'otu n'otu. Dị ka ị pụrụ ịhụ, usoro usoro usoro ọgwụgwọ ahụ dị obosara, nke na-eme ka usoro ịhọrọ nhọrọ dịkwuo mma.

Dodoụbiga ya ókè

Eweputara bradypnea na nsogbu ahunkụda mmụọ nke akụkụ iku ume, bradycardia, mgbaka ike, iwetulata ọbara. Wepu TTC ma ọ bụrụ na ọ dị mkpa - enyemaka ikuku, nchịkwa mgbochi naloxone. Ọrịa Symptomatic: iwebata akwara anụ ahụ, atropine ya na bradycardia.

Mmekorita

Ihe ọghọm nke hypoventilation, ịationụ ọgwụ oke na mbelata ọbara mgbali mgbe ị na-eji ọgwụ ọjọọ na-abawanye, na-akụda ọrụ nke sistemụ akwara etiti: nyocha opioid, ihe nchoputa, ogwugwo ya naọgwụgwọ ụlọ, phenothiazines, ọgwụ mgbochi, ntụgharị akwara dị n’etiti.

A na-achọpụta mmụba na ndọta plasma na oge ịmachi ahụ ka a na-ewere ya Ndị na-egbochi CYP3A4 (ritonavir, Ketoconazole, troleandomycin, clarithromycin, itraconazole, Nelfinavir, Amiodarone, Verapamil, Nefadozone, diltiazem).

Durogezik na-eme ka mmetụta ahụ kawanye mma ọgwụ antihypertensive.

Belata mmetụta analgesic nke ọgwụ buprenorphine, pentazocine, nalbuphine, naltrexone, naloxone.

Atụrụ jụụ kpochapu isi ike. Oge izu ike akwara nwere ọrụ vagolytic na - belata ihe egwu bradycardia na hypotension, mmega ahụ na - abụghị vagolytic na - ebulite ohere nke mmeghachi omume ọjọọ site na CCC.

O gha emelata belata fentanyl mgbe ejiri ya GKS, insulin na ọgwụ antihypertensive.

Mwepụta wepụtara ya na ihe mejupụtara

A na-emepụta Durogesic n'ụdị usoro ọgwụgwọ ọrịa transdermal (TTC): akụkụ nwere akụkụ anọ nwere nkuku gburugburu, translucent, na-ejigharị ya, nwere jelii transperent, jel na-enye ohere ọnụnọ nke mkpu na ikuku na-egosipụta, ihe e dere na shei mpụta: pink, 0.025 mg / h, 0.05 mg / h - ahịhịa ndụ, 0.075 mg / h - acha anụnụ anụnụ, 0.1 mg / h - isi awọ (1 pc. N'ime akpa jikọtara ọnụ, akpa 5 n'ime igbe kaadi).

Ngwakọta nke usoro 1 gụnyere:

Ihe eji arụ ọrụ: fentanyl - 2.5 mg, 5 mg, 7.5 mg ma ọ bụ 10 mg,
Ihe inyeaka: cellulose hydroxyethyl, mmanya etyl, mmiri dị ọcha.

Ngwakọta nke arụmọrụ nke patch:

Ihe mpụga nke ọzọ: copolymer nke ethylene vinyl acetate na polyester,
Ihe ndozi: ethanol (0.1 ml / 10 cm 2) na fentanyl (2.5 mg / 10 cm 2) dị ka gallulose hydroxyethyl mmiri,
Akpụkpọ agba na-ahapụ: ethylene vinyl acetate (na-achịkwa ọnụego ntọhapụ nke ihe ahụ nọ n'ọrụ),
A na-eji mkpuchi mkpuchi silicone kpuchie ihe nkiri nchebe na-echebe: polyester na fluorocarbon diacrylate.

Usoro onunu ogwu na nhazi

Dọkịta ahụ na-ahọrọ usoro nke Durogezik n'otu n'otu dabere n'ọnọdụ onye ọrịa yana nyocha oge niile maka mgbanwe mgbe etinyere TTC.

A na-etinye kwachie a n'elu anụ ahụ nke ogwe aka elu ma ọ bụ ogwe aka ya. Maka ngwa, ịkwesịrị ịhọrọ ebe nwere obere ntutu isi. Tupu ojiji, a ga-ebipụ ntutu dị na ntinye akwụkwọ (emela ntutu). Ọ bụrụ na ọ dị mkpa ịsacha anụ ahụ tupu itinye ya n'ọrụ, ejila ncha, mmanụ, lotions ma ọ bụ ụzọ ndị ọzọ maka nke a, ka ị ghara ịkpasu iwe ma ọ bụ mgbanwe na akụrụngwa ya. Tupu ngwa ahụ, akpụkpọ ahụ ga-adịrị asị kpamkpam.

A na-etinye gluiggege ozugbo a na-ewepụtacha ya na akpa ejikọtara ya, na-eji nkwụ ya na-etinye ya n’ime sekọnd iri atọ n’ebe a na-etinye ya. Ikwesiri igba mbọ hụ na akpachasị ahụ dabara na anụ ahụ, ọkachasị n'akụkụ ya.

Emere Durogezik maka ojiji na-aga n'ihu ruo awa 72. Enwere ike ịmịnye usoro ọhụrụ n'akụkụ anụ ahụ naanị mgbe ewepụchara glued mbụ. N’otu ebe na otu akpụkpọ ahụ, enwere ike ịmịchaa ịmachi ahụ site na izu ike ọtụtụ ụbọchị.

Na ntinye izizi, a na-ahọpụta usoro onodu ogwu (nha nke sisitemu) dabere na ọnọdụ onye ọrịa, ojiji mbụ na nyocha opioid yana ogo nnagide. Ọ bụrụ na emebeghị opioids edeburu, ekwesịrị iji 25 μg / h mee ihe dịka usoro ọgwụgwọ mbụ. A na-atụkwa otu usoro ahụ ma ọ bụrụ na onye ọrịa ahụ enwetara ya na Promedol na mbụ.

N'ime ndị ọrịa nwere nnabata opioid, mgbe ha na-agbanwe site na parenteral ma ọ bụ ụdị nke opioids gaa Durogesic, a na-agbakọ usoro ahụ dabere dabere na awa 24 gara aga nke analgesia.

Maka ntụgharị nke ọma site n'otu ọgwụ gaa na ọzọ, ekwesịrị ịkagbu ọgwụgwọ izizi nke mbụ ya na ntinye ọgwụ nke Durogezik.

Ọ bụrụ na enwetaghị ihe enyemaka mgbu zuru oke mgbe etinyere ọgwụ mbụ, mgbe ụbọchị 3 nwere ike ịbawanye usoro onwa site na 25 μg / h, agbanyeghị, ekwesịrị iburu ọnọdụ onye ọrịa ahụ na mkpa mgbakwunye mgbu ọzọ (ọnụọgụ ọgwụ morphine nke 90 mg / ụbọchị dị ihe kwekọrọ na 25 μg / h Durogesic) . Iji mezuo ọnụọgụ karịrị 100 μg / h, enwere ike iji ọtụtụ TTC n’otu oge.

Ọ bụrụ na mgbu “na-egbu”, ndị ọrịa nwere ike ịchọ ọgwụ ndị ọzọ na-adịghị adịte aka. Patientsfọdụ ndị ọrịa nwere ike ịchọ ụzọ ọzọ ma ọ bụ ụzọ ndị ọzọ ha si eji nchịkwa opioid mgbe ha na-eji usoro gafere 300 mcg / h.

Ntụziaka pụrụ iche

Ọrịa ndị mepụtara mmetụta dị oke njọ kwesịrị ịnọ na nlekọta ahụike maka otu ụbọchị mgbe ewepụchara Durogezik.

Ọgwụ ahụ, tupu ma ọ bụ mgbe ejiri ya, ga-echekwa ya ebe ụmụaka agaghị eru.

Enwere ike imebi patch ahụ n'ụzọ ọ bụla ma kewaa ya na akụkụ ma ọ bụ bee, n'ihi na nke a nwere ike ibute ntọhapụ nke fentanyl.

Ọ bụrụ na ọ dị mkpa ịkwụsị iji Durogezik, ndochi ya na opioids ndị ọzọ kwesịrị ịmalite nwayọọ nwayọọ iji zere mmepe nke ọrịa nloghachi.

Ọgwụ a nwere ike imetụta ọrụ nke uche na nke anụ ahụ dị mkpa mgbe ị na-arụ ọrụ ihe egwu, dị ka ịnya ụgbọ ala ma ọ bụ ịrụ ọrụ. N'oge usoro ọgwụgwọ, mmadụ kwesịrị ịhapụ ịnya ụgbọ ala na ịrụ ụdị ọrụ egwu nwere ike ịchọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor site na onye ọrịa.

Mgbe emesachara ya, ekwesịrị ịrakọta ya na akụkụ ahụ rapara na ya n'ime ọkara ma gaghachi na nke dọkịta maka mbibi ọzọ n'ụzọ enyere n'iwu. Ekwesịrị ịlaghachi dọkịta ahụ ihe ndị ọzọ na-ejighị.

Site na ihe na - arụ ọrụ - Durogezik Matrix, Lunaldin, Fendivia,
Site na usoro nke ime ihe - Bupranal, Ultiva, Prosidol, Dipidolor, Morphine, Palexia, Nopan, Promedol, Scanan, Fentanyl na nyocha ọgwụ opioid ndị ọzọ.

Ntuziaka maka iji Durogesic: usoro na usoro onunu ogwu

A na-etinye Durogezik n'usoro. Ekwesịrị itinye TTS na ala akọrọ kpamkpam nke akpụkpọ ahụ nke ogwe aka elu ma ọ bụ ogwe. Maka ngwa, a na-atụ aro ịhọrọ ebe nwere obere ntutu isi. A ga-ebipụ ntutu n’ebe a na-etinye ngwa (emela ntutu). Ọ bụrụ na saịtị a ga-achọ ịsa ahụ tupu iji Durogezik, ekwesịrị iji mmiri dị ọcha mee nke a na-ejighị ncha, lotions, mmanụ ma ọ bụ ụzọ ndị ọzọ, n'ihi na ha nwere ike ibute mgbakasị anụ ahụ ma ọ bụ mgbanwe na akụrụngwa ya.

Gluu mkpọchi Durogezik ozugbo ewepụsịrị ya na akpa akara. Ekwesịrị iji aka gị pịa TTS na ntinye ngwa ahụ maka sekọnd 30. Ikwesiri igba mbọ hụ na akpachasị ahụ dabara na anụ ahụ, ọkachasị n'akụkụ ya.

Emere Durogezik ka elekere 72 were iji ya rụọ ọrụ. Enwere ike ịmịnye usoro ọhụrụ ahụ n'akụkụ ọzọ nke anụ ahụ ma wepụsịa oghere mmachi ahụ. Naanị ihe ị ga-eme bụ ịgbanye TTS n'otu mpaghara ahụ naanị mgbe ezumike ọtụtụ ụbọchị.

A na-ahọrọ dose nke ọgwụ ahụ n'otu n'otu dabere n'ọnọdụ onye ọrịa (a ga-enyochagharị ya mgbe ngwa TTC ọ bụla gasịrị).

Mgbe ị na-eji Durogezic maka oge izizi, ahọpụtara oke nke sistemụ ahụ (ọnụọgụ) dabere na ojiji mbụ nke ndị nyocha opioid, ọnọdụ onye ọrịa na ogo ndidi. N'ime ndị ọrịa na-ewerebeghị ọgwụ opioids mbụ, a na-enye ọgwụ kachasị dị ka ọgwụ mbido - 0.025 mg / h. A na-eji otu ọgwụ ahụ eme ihe maka ndị ọrịa nwetagoro Promedol.

Mgbe ị na-agbanwe n'ụdị opioids na parenteral ma ọ bụ nke ọnụ ka ọ bụrụ Durogesic na ndị ọrịa nwere nnabata opioid, a na-agbakọ dose ahụ n'otu n'otu.

Agaghị eme nyocha nyocha kachasị maka ọgwụ ọgwụ gafere tupu elekere iri abụọ na anọ mgbe etinyere ngwa ahụ, n'ihi mmụba nwayọọ nwayọọ na ịba ụba nke fentanyl na ọbara.

Maka mgbanwe na-aga nke ọma site na otu ọgwụ gaa na ọzọ, a ga-akagbu ọgwụgwọ ọgwụgwọ gara aga ka ejiri nwayọ kwụsịges.

Ọ bụrụ na egbochighị ahụ mgbu zuru oke mgbe etinyechara usoro ọgwụgwọ mbụ, ka ụbọchị atọ gasịrị, enwere ike ịbawanye dose ahụ. Ọzọkwa, ọ ga-ekwe omume ịbawanye ọgwụ ahụ kwa ụbọchị 3. N'otu oge, a na-agbakarị ọgwụ ahụ site na 0.025 mg / h, agbanyeghị, a ga-elebara ọnọdụ onye ọrịa ahụ anya na ịchọrọ nyocha ọzọ (ọgwụ ọnụ kwa ụbọchị nke 90 mg morphine dị ihe kwekọrọ na Durogesic dose nke 0.025 mg / h). Iji mezuo ọnụọgụ karịrị 0.1 mg / h, enwere ike iji ọtụtụ TTC mee otu oge. Site n'oge ruo n'oge, mgbe ihe mgbu “na-agbawa”, ndị ọrịa nwere ike ịchọ ọgwụ ndị ọzọ na-adịghị adịte aka. Patientsfọdụ ndị ọrịa, mgbe ị na-eji ọgwụ Durogesic karịa 0.3 mg / h, nwere ike ịchọ usoro ọzọ ma ọ bụ ụzọ ọzọ nke na-eduzi nyocha opioid.

Ime na lactation

A na-ele ozi banyere iji Durogesic n'ime ụmụ nwanyị dị ime ezughị ezu. Ekwesighi ịkọ ya n'oge afọ ime, belụsọ n'ọnọdụ mkpa dị ngwa.

Eji ọgwụ a na-amụ nwa mgbe amụ nwa, ebe ọ bụ na fentanyl na-emeri ihe mgbochi placental ma nwee ike iduga mgbochi nke akụkụ okuku ume na nwa amụrụ ọhụrụ.

A na-ahụ Fentanyl na mmiri ara, na-agwọ ya ọgwụ ma nwee ike ịkpasu nsogbu iku ume na ụmụaka. N'akụkụ a, a naghị akwadoro maka ojiji n'oge a na-enye ya ara.

Mkparịta ụka ọgwụ ọjọọ

Site n'otu oge iji Durogezic na ọgwụ ụfọdụ, mmetụta ndị a nwere ike ime:

Ọgwụ ndị ọzọ nwere mmetụta nkụda mmụọ na sistemụ akwara na-esite, gụnyere opioids, hypnotics na mgbochi, phenothiazines, ọgwụ akwara, akwara umeji, akwara, antihistamines nwere mmetụta akụrụngwa, ihe ọ alcoụ alcoụ na-aba n’anya: ịba ụba nke mmepe na ịba ụba hypoventilation, belata akwara akwara. nrụgide, ịationụ ọgwụ oke (ọgwụgwọ nkwonkwo chọrọ nlekọta pụrụ iche maka ọnọdụ onye ọrịa ahụ),
Ihe nwere ike ịbụ Cytochrome P Inhibitors₄₅₀ CYP3A4 (ritonavir): mmụba na mkpokọta fentanyl na plasma, nke na - eme ka enwere ike ịkwalite ma ọ bụ ịgbatị mmetụta ọgwụgwọ na omume nke nsonaazụ ndị ọzọ (ọ naghị atụ aro ka nkwonkwo a),
Nitrous oxide: ubara akwara siri ike,
Buprenorphine: mbelata na nsonaazụ Durogesic,
Monoamine oxidase inhibitors: ohere nke nnukwu nsogbu.

Mgbe ejikọtara ya na insulin, glucocorticosteroids na ọgwụ antihypertensive, ọ dị mkpa iji belata dose nke fentanyl.

Ihe atụ nke Durogezik bụ: Lunaldin, Fendivia, Dolforin, Fentadol Reservoir, Fentadol Matrix, Dolforin, Durogezik Matrix.

Nyocha banyere Durogezik

N'ụzọ bụ isi, netwọk ahụ na-eweta nyocha dị mma banyere Durogezik. Ndị ọrịa na-akọ na ịdị mfe nke iji ya ma dị irè na ogologo oge (ọgwụ ahụ na-adịgide ruo ụbọchị 3) enyemaka nke mwakpo ihe mgbu, nke na-atụnye ụtụ na njiri dị elu na ogo ndụ. Usoro a nke analgesia bu ihe ndi mmadu anabataghi nke oma nye otutu ndi ọrịa ma e jiri ya tunyere ya igba ndi na egbu egbu.

Ọrịa ndị burula ụzọ jiri morphine kwuo okwu na Durogezic anabataghị. Ọ na - enyere gị aka iwepu afọ ntachi, nke bụ oge mmeghachi omume ị takingụ ọgwụ nwere morphine. Agbanyeghị, ọgwụ ahụ nwekwara mmetụta ndị ọ na-akpata, n’ime nke ọgbụgbọ na ọgbụgbọ na-ekwukarị, n’ihe ndị dịpụrụ adịpụ, afọ ntachi. Nausea na-apụkarị naanị n'ime ụbọchị 5-7, mana oge ụfọdụ ndị ọrịa na-ewere ọgwụ mgbochi obere obere. Dependdabere na iji ọgwụ ọjọọ eme ihe anaghị etolite. Mgbe ụfọdụ, mgbe etinyere Dyurogezik, a na-ahụ mmeghachi omume nfụkasị ahụ n'ụdị hyperemia, nke na-agabiga onwe ya ma ọ bụ mgbe ọ takingụsịrị ọgwụ antihistamines.

Ntuziaka maka iji Durogezik (usoro na usoro onunu ogwu)

A họrọ dose nke Durogezik n’otu n’otu dabere n’ọnọdụ onye ọrịa ahụ.

A họrọ usoro mbu (ọnụọgụ nke sistemụ) maka ojiji izizi dabere na ojiji mbụ nke nyocha opioid, ọnọdụ onye ọrịa na ogo ndidi.

N'ime ndị ọrịa na-ewerebeghị ọgwụ opioid mbụ, a na-eji ntakịrị 25 μg / h dị ka ọgwụ mbụ. Ọ bụrụ na onye ọrịa ahụ anatalarịrị Promedol, etinyere Durogesic n’otu usoro ahụ.

Mgbanwe sitere na parenteral ma ọ bụ nke ọnụ nke nyocha nke opioid na Durogesic na ndị ọrịa nwere ntachi obi na opioids ga-emerịrị n'usoro ndị a:

Gbakọọ mkpa elekere iri abụọ na anọ gara aga maka analgesia.
Gbanwee ego a na ọgwụ morphoine na mkpokọ kwekọrọ na tebụl 1. Niile ọnụ na IM nke nyocha nke opioid nke egosiri na tebụl ahụ kwekọrọ na mmetụta analgesic ruo 10 mg IM morphine.
Họrọ ogwu a chọrọ awa 24 nke morphine maka onye ọrịa na ọgwụ kwekọrọ na Durogesic.

Aha ọgwụ ọjọọ	n'ime / m	Ngwọta nyocha kwesiri ya (mg), site na ọnụ
Morphine	10	30 (iji ya na-achịkwa mgbe niile), 60 (ya na ndị ọzọ na-elekọta ya)
Omnopon	45	-
Hydromorphone	1,5	7,5
Methadone	10	20
Oxycodone	15	30
Levorphanol	2	4
Igwefoto	1	10 (n'ụzọ nkịtị)
Diamondphine	5	60
Petidine	75	-
Codeine	130	200
Buprenorphine	0,3	0.8 (asụsụ n’asụsụ abụọ)

Usoro ntụgharị na usoro ọgwụgwọ mmezi

A ga-eji TTS Durogezik dochie ya na nke ọ bụla n'ime awa iri asaa na asaa.

Ọ bụrụ na egbochighi izizi ahụ ka etinyere ọgwụ nke izizi, emesịa mgbe ụbọchị atọ gasịrị, enwere ike ịbawanye dose ahụ. Mgbe ahụ enwere ike ịbawanye dose ahụ n'etiti nkeji atọ. Ọtụtụ mgbe, a na-amụba dose ahụ site na 25 mcg / h n'otu oge.

Iji mezuo uzo kariri 100 μg / h, enwere ike iji ọtụtụ TTC mee ihe nke ọma.

Site n'oge ruo n'oge, ndị ọrịa na-achọ usoro ọgwụgwọ ndị ọzọ dị mkpirikpi oge ihe mgbu na-apụta. Patientsfọdụ ndị ọrịa chọrọ ụzọ ọzọ ma ọ bụ ụzọ ndị ọzọ ha si eji nchịkwa opioid mgbe ha na-a aụ ọgwụ Durogesic karịa 300 mcg / h.

Nsonaazụ

Ojiji nke Durogezik nwere ike ibute nsogbu ndị a:

Sistemụ akwara na akụkụ ahụ: isi ọwụwa, iro ụra, nchekasị, ọgba aghara, ihe ndọrọndọrọ, anorexia, ịda mba, oge ụfọdụ paresthesia, akwara, amnesia, ehighi ura, ọgba aghara, nsogbu.
Usoro obi: wedata ọbara mgbali elu, bradycardia, ọbara mgbali elu, tachycardia.
Usoro nri: ala akọrọ, ọgbụgbọ, afọ ntachi, vomiting, dyspepsia, biliary colic (na ndị ọrịa nwere akụkọ banyere ha), oge ụfọdụ - afọ ọsịsa.
Usoro iku ume: bronchospasm, hypoventilation na nkụda mmụọ (yana oke ị overụ ọgwụ), na obere oge - mkpụmkpụ ume.
Mmeghachi omume mpaghara: erythema, rashes akpụkpọ ahụ na itching na saịtị nke ngwa.
Ndị ọzọ: ọsụsọ na-abawanye, njigide nke urinary, akwara dị mkpụmkpụ mkpụmkpụ (gụnyere pectoral), itching, ndidi, yana ntinye uche na anụ ahụ, n'ọnọdụ ndị dị ụkọ, dysfunction mmekọahụ, asthenia na syndrome syndrome.

Nhapụ eweputara Durogezik, nkwakọ ọgwụ na ihe mejupụtara.

Usoro transdermal ọgwụgwọ (TTC) nwere mpaghara kọntaktị nke 10 cm2 na fentanyl mgbapụta nke 25 μg / h bụ akụkụ anọ translucent patch nwere akụkụ gbara ya gburugburu, nwere jelii transperent, ihe ederede "25 μg / h" bụ pink na mpụga nke patch. 1 TTC fentanyl 2.5 mg
Ndị ọkachamara: cellulose hydroxyethyl, ethanol, mmiri dị ọcha.
Ngwakọta nke mpụga ihe nchebe TTC: copolymer nke polyester na ethylene vinyl acetate.
Ngwakọta nke olulu nwere ihe eji arụ ọrụ: jel aqueous based based hydroxyethyl cellulose.
Ngwakọta nke akpụkpọ ahụ mwepụta nke TTC, na-achịkwa usoro ntọhapụ nke fentanyl: ethylene vinyl acetate.
A na-eji ihe mkpuchi silikoni mee ka ọ bụrụ nke a na-ahụ maka ihe nkiri ahụ na - ewepu mmiri:
1 pc - akpa (5) - ngwugwu nke kaadiboodu.
Usoro transdermal ọgwụgwọ (TTC) nwere mpaghara kọntaktị elu nke 20 cm2 na fentanyl mgbapụta nke 50 μg / h, bụ translucent rectangular patch nwere akụkụ gbara ya gburugburu, nwere jelii transperent, na mpụga nke patch ahụ enwere ederede akwụkwọ ndụ akwụkwọ ndụ dị "50 lightg / h". 1 TTC fentanyl 5 mg
Ndị ọkachamara: cellulose hydroxyethyl, ethanol, mmiri dị ọcha.
Ngwakọta nke mpụga ihe nchebe TTC: copolymer nke polyester na ethylene vinyl acetate.
Ngwakọta nke olulu nwere ihe eji arụ ọrụ: jel aqueous based based hydroxyethyl cellulose.
Ngwakọta nke akpụkpọ ahụ mwepụta nke TTC, na-achịkwa usoro ntọhapụ nke fentanyl: ethylene vinyl acetate.
A na-eji ihe mkpuchi silikoni mee ka ọ bụrụ nke a na-ahụ maka ihe nkiri ahụ na - ewepu mmiri:
1 pc - akpa (5) - ngwugwu nke kaadiboodu.
Usoro transdermal ọgwụgwọ (TTC) nwere mpaghara kọntaktị elu nke 30 cm2 na fentanyl tọhapụ nke 75 μg / h, bụ translucent akụkụ anọ nwere akụkụ gbara ya gburugburu, nwere jelii transperent, ihe edere “75 μg / h” dị na mpụga nke patch. 1 TTS fentanyl 7.5 mg
Ndị ọkachamara: cellulose hydroxyethyl, ethanol, mmiri dị ọcha.
Ngwakọta nke mpụga ihe nchebe TTC: copolymer nke polyester na ethylene vinyl acetate.
Ngwakọta nke olulu nwere ihe eji arụ ọrụ: jel aqueous based based hydroxyethyl cellulose.
Ngwakọta nke akpụkpọ ahụ mwepụta nke TTC, na-achịkwa usoro ntọhapụ nke fentanyl: ethylene vinyl acetate.
A na-eji ihe mkpuchi silikoni mee ka ọ bụrụ nke a na-ahụ maka ihe nkiri ahụ na - ewepu mmiri:
1 pc - akpa (5) - ngwugwu nke kaadiboodu.
Usoro transdermal ọgwụgwọ (TTS) nwere mpaghara kọntaktị nke 40 cm2 na fentanyl mgbapụta nke 100 μg / h, bụ translucent rectangular patch nwere akụkụ gbara ya gburugburu, nwere jelii transperent, na mpụga nke patch ahụ, e nwere ihe odide isi awọ "100 μg / h". 1 TTC fentanyl 10 mg
Ndị ọkachamara: cellulose hydroxyethyl, ethanol, mmiri dị ọcha.
Ngwakọta nke mpụga ihe nchebe TTC: copolymer nke polyester na ethylene vinyl acetate.
Ngwakọta nke olulu nwere ihe eji arụ ọrụ: jel aqueous based based hydroxyethyl cellulose.
Ngwakọta nke akpụkpọ ahụ mwepụta nke TTC, na-achịkwa usoro ntọhapụ nke fentanyl: ethylene vinyl acetate.
A na-eji ihe mkpuchi silikoni mee ka ọ bụrụ nke a na-ahụ maka ihe nkiri ahụ na - ewepu mmiri:
1 pc - akpa (5) - ngwugwu nke kaadiboodu.

Nkọwa ọgwụ a sitere na ntuziaka masịrị iwu maka iji ya eme ihe.

Eme ihe banyere ọgwụ Durogezik

Ihe nyocha opioid maka transdermal. Fentanyl bụ analgesic analgesic nke na - emekọrịta ihe kachasị na ndị na-anabata mu-opioid. Ọ bụ ndepụta nke ọgwụ ọgwụ ọjọọ II, ọgwụ psychotropic na usoro ha, nke Iwu Iwu nke gọọmentị Russia Nọmba 681 nke 06/30/98 kwadoro. Na-abawanye ọrụ nke usoro antinociceptive, na-eme ka ọnụ ụzọ nke mmetụta ihe mgbu dịkwuo elu. Ọ na-emebi mgbasa nke mkpachapụ anya n'okporo ụzọ ihe mgbu na nke anaghị akọwapụtakwa ya gaa na akwara nke thalamus, hypothalamus, na amygdala.
Mmetụta ọgwụgwọ bụ isi nke ọgwụ ahụ bụ ọgwụ na-akụ ọgwụ. Obere nyocha kachasị dị mma nke fentanyl na plasma n'ime ndị ọrịa na-ejitabeghị ọgwụ opioid mbụ bụ 0.3-1.5 ng / ml. Oge ngụkọta ọgwụ ahụ bụ awa 72
Ọ nwere mmetụta na-akụda mmụọ na mpaghara okuku ume, na-agbada ụda obi, na-eme ka akwara ahụ ike na etiti ọgbụgbọ na-agbọpụta. Na –eme ka ụda olu dị nro nke biliary tract, sphincters (gụnyere urethra, eriri afo, sphincter nke Oddi), belata motility eriri afọ, na - eme ka mmịpụta nke mmiri dị na mpe mpeze. Fọrọ nke nta ọ nweghị mmetụta ọ bụla na ọbara mgbali, na-ebelata usoro ọbara gbasara akwara. N'ime ọbara na-abawanye ọdịnaya nke amylase na lipase.
Na-akwalite mmalite nke ụra. Na-akpata obi ụtọ.
Ugo nke mmepe nke ịdabere na ọgwụ na ndidi maka mmetụta analgodi mara ọdịiche dị iche iche nke mmadụ.

Usoro onunu ogwu na uzo icho ogwu a.

Ekwesịrị ịhọrọ dose nke Durogezic n'otu n'otu dabere n'ọnọdụ onye ọrịa yana izu oke ya mgbe nyochachara ngwa TTC.
A họrọ usoro mbu (ọnụọgụ nke sistemụ) maka ojiji izizi dabere na ojiji mbụ nke nyocha ọgwụ opioid, ogo nnabata na ọnọdụ onye ọrịa.
N'ime ndị ọrịa na-ewerebeghị ọgwụ opioid mbụ, a na-eji ọgwụ mgbochi Durogesic dị ala, 25 μg / h dị ka ọgwụ mbụ. Edere ọgwụ ahụ otu ọgwụ ma ọ bụrụ na onye ọrịa ahụ enwetala ọgwụ ọgwụ na mbụ.
Mgbanwe sitere n'ụdị ọnụ ma ọ bụ nke parenteral nke nyocha nke opioid na Durogesic na ndị ọrịa nwere ntachi obi na opioids kwesịrị ịme usoro n'usoro.
1. Gbakọọ mkpa elekere iri abụọ na anọ gara aga maka analgesia.
2. Gbanwee ego a ka ọnụego morphine ọnụ nke kwekọrọ na tebụl 1. Niile IM na ọnụọgụ nke opioid analgesics enyere na tebụl a dabara na mmetụta analgesic ruo 10 mg IM morphine.
3. Na tebụl nke abụọ, chọta awa nke ọgwụ morphine chọrọ awa 24 maka onye ọrịa na ọnụọgụ kwekọrọ na Durogesic.
Tebụl 1. Nyefee na ọgwụ analgesic hà aha ọgwụ ọgwụ nha analgesic dose (mg) m / m * ọnụ Morphine 10 30 (yana nchịkwa oge) ** 60 (nwere otu ma ọ bụ otu oge) Omnopon 45 - Hydromorphone 1.5 7.5 Methadone 10 20 Oxycodone 15 30 Levorphanol 2 4 Oxymorphone 1 10 (akwara) diamorphine 5 60 Petidine 75 - Codeine 130 200 Buprenorphine 0.3 0.8 (asụsụ sublingual)

* A na-atụ aro usoro onunu a site na ịgbanwo ya site na parenteral gaa n'ụzọ ọnụ nke nchịkwa.

** Oru nke ike nke ihe nke morphine n’uzo oru intramuscular / onu nke ochichi, ra ka 1: 3, dabere na nnabata nke ulo ogwu nke enwetara n’ilebara ndi oria obi mgbu.
Tebụl 2. Ngwọta ọgwụ tụrụ aro Durogesic (ọ dabere na ọgwụ ọnụ kwa ụbọchị nke morphine) * dosebọchị a na-aralụ ọgwụ morphine (mg / ụbọchị) Dose nke Durogesic (μg / h) 2013-03-20

International Nonproprietary Aha

Ọtụtụ mgbe, dọkịta na-ede ọgwụ maka ọgwụ na Latin. Phentanylum (fentanyl) - aha nke ihe eji eme ihe.

Durogezik bụ otu n'ime ọgwụ ndị nwere ọgwụ na-akụ ọgwụ na ọgwụ mgbu.

N02AB03 - koodu maka anatomical na ọgwụgwọ kemịkalụ kemịkalụ.

Weputara udi ya na ihe mebere ya

A na-eme ọgwụ ahụ n'ụdị akụkụ nwere akụkụ anọ nwere ya na gel transperent dị na ya.

Ngwakọta ọgwụ a nwere fentanyl. Ọnụego ntọhapụ nke ihe psychotropic bụ 25 μg / h na 50 μg / h.

A na-eme ọgwụ ahụ n'ụdị akụkụ nwere akụkụ anọ nwere ya na gel transperent dị na ya.

Jiri nlezianya

Ọ na-atụ aro iji transdermal patch n'ọtụtụ ọnọdụ dị otú a:

Ọnụnọ nke ọrịa nkuume na-adịghị ala ala.
Ọ bụrụ na nrụgide intracranial dịkwuo elu.
Site na mbelata nke mgbali ọbara.
Na ọdịda akụrụngwa ma ọ bụ ịba ọcha n'anya.
A na-eji Durogesic mee ihe maka ihe mgbu neuropathic nke na-apụta na ọtụtụ sclerosis na polyneuropathy na-arịa ọrịa shuga (mgbanwe degenerative na eriri akwara).
Edere ọgwụ ahụ maka oke ihe mgbu n'ihu ọnya cancer.
A na-atụ aro Durogezik maka ụdị mgbu ọgbụgba maka ọrịa nke usoro akwara.
A akwadoghị Durogesic maka ojiji maka ọnụnọ nke ọrịa nkuume na-adịghị ala ala.
Ejighị patch ahụ mee ihe mgbe enwere ike nrụgide intracranial.
A naghị akwado Durogezik maka iweda ọbara mgbali elu.

Ebee gluu

A ga-etinyere ngwaahịa a ruo n’ala akpịrị nke akpati ma ọ bụ ubu. Ọ dị mkpa tupu ịkpụ ntutu n'isi. Can nweghị ike iji ọgwụ ịchọ mma niile dị iche iche tupu ị na-eji patch zere mmeghachi ahụ nfụkasị ma ọ bụ belata nsonaazụ ọgwụgwọ ọgwụgwọ ọgwụ.