Etu esi eji Cozaar? > Ọgwụgwọ na mgbochi

Ihe na-arụ ọrụ bụ onye irondị na-anabata ya angiotensin 2. Ihe a na - egbochi mmetụta niile. antiotensin, n'agbanyeghị ụzọ nke ahụ enzyme sitere na ya, ma obu site na nke esiri nweta ya. A maara nke ahụ angiotensin 2(ike vasoconstrictor) bụ ihe dị mkpa mmepe ọbara mgbali ike. Na mgbakwunye, ihe na-arụ ọrụ adịghị arụ ọrụ dị ka onye anakpo angiotensin.

Ihe owuwu ahụ na-esoro nke ọma Ndị na-anabata AT1n’agaghị emetụta ndị na - anabata ndị ọzọ ọhụhụ na homonụ. Losartan enweghị mmetụta ọ bụla na ya kininase 2 na bradykinin. E gosiputara na ihe di n’ime ogwu ahu abughi ihe kpatara ya edema.

Mgbe ị theụsịrị ọgwụ ahụ, mmekọrịta dị n'etiti mkpesa na-apụ n'anya angiotensin 2 na nzuzo reninihe omume ARPna-abawanye.

Mgbe ọgwụgwọ ya gachara ọgwụ maka izu isii, ịta ahụ angiotensin 2 na-abawanye site na ugboro 2-3. Ihe mgbochi dị mma nke ndị na-anabata ya na-ewere ọnọdụ, nke na-egosipụta onwe ya kpamkpam ụbọchị 14-48 ụbọchị mgbe ịmalite ị theụ ọgwụ ahụ.

E gosiputara na ogwu ahu enweghi ike ya ahịhịa n.s. na ukpụhọde, ịta shuga n'ime ọbara. Losartan dị nnọọ iche na ọgwụ Ihe mgbochi ACEọ na - egbochi mmetụta angiotensin 1 na 2na-enweghị emetụta bradykinin(Ihe mgbochi ACE mee ihe n'uzo ozo).

Na-abawanye na usoro ị theụ ọgwụ, mmetụta ya hypotensive na-abawanye.

Mgbe ị na-enwe ọmụmụ ihe na ụmụ nwoke dị mma, mgbe ha takingụsịrị ọgwụ ọgwụ 100, belata nnu ma ọ bụ nnukwu nnu nriọsọ ịlọ ụwa,mpekere nnabatana ọrụ akụrụ n’ozuzu agbanwebeghị. Agbanyeghị, ịdị ike nke urinary acid napụrụ excretion nke akụrụ na ọdịnaya nke sodium na mmamịrị mụbara.

N'ime ụmụ nwanyị nọ menopause oge nke ịta ahụhụ site n'ịba ụba ọbara mgbalina ị dailyụ ọgwụ kwa ụbọchị 50 nke ọgwụ ọgwụ maka ọkwa otu ọnwa PGagbanweghi.

N’ime ule dị iche iche, ebumnuche ya bụ ịtụle dabere ọdịmma, onwu na oge nkụchi obi, n’ebe ndị ọrịa nọ CNS si usoro ubochi nile losartan, ekwuputala na ogwu n’eji otu ogwu gwo ogwu nke oma kariri 50 mg. A mụwo ọmụmụ ihe afọ anọ.

Mbadamba mbadamba Ọkpụkpụ afọ, akụrụngwa Cozaar na-arụ ọrụ na-arụ ọrụ nke ọma ma na-agbakarị ọsọ ọsọ, na-abanye na sistem sistemụ metabolized (14%) na anụ ahụ nke imeju. Losartan ụdị arụmọrụ (ebulana) na-adịghị arụ ọrụ (N-2-tetrazole-glucuronide) metabolites. Bioavailability bụ ihe dịka 30%. A na-ahụta nsonaazụ kachasị nke losartan mgbe minit 60 gasịrị, metabolites ya - mgbe awa 3.5 gachara. Pharmacokinetic paramita anaghị akwụ ụgwọ maka nri nri.

Ọgwụ nwere oke nkwado dị na protein na plasma - ihe dị ka 99%. Ihe nọ n'ọrụ anaghị abanyemgbochi mgbochi ụbụrụ.

Ọgwụ ahụ dị n'ụdị metabolites ma ọ bụ akụrụ na feces na-agbanweghi, na nkeji 120 na awa 5-6, n'otu n'otu. Mgbe ị na-ewere 100 mg ọgwụ ọjọọ kwa ụbọchị, ọ naghị enwekarị ike ịgbakọta na ahụ.

Pharmacokinetic parameters atụkwasịla afọ ndụ. Agbanyeghị, na ụmụ nwanyị, plasma ịta n'ihe arụ ọrụ ji okpukpu abụọ karịa nke ụmụ nwoke.

N'ime ndị ọrịa nwere ọrịa imeju (ya na cirrhosis) plasma ịta bụ ọtụtụ ugboro elu karịa na ahụ ike.

Nanwechapụ ihe karịrị 10 ml kwa nkeji, n'ime mmadụ anaghị ịba ọcha n'anya, ndị na-egosi ọgwụ adịghị iche nke ukwuu. A naghị ewepụ ngwaahịa ahụ n'oge ịba ọcha n'anya.

Ihe ngosi maka ojiji

ndị mmadụ na-ata ahụhụ site na ọbara mgbali ike,
iji chebe akụrụ mgbe ọrịa shugaỤdị 2 ya na proteinuria,
iji belata ihe ize ndụ nke ịmalite nkụchi obi (ọrịa obi, nkụchi obi) ma ọ bụ onwu na ndị ọrịa nwereaka ekpe ventricular hypertrophy na abawanye EGO,
na nkụda obi na-adịghị ala ala, ya na ntachi obi ma ọ bụ enweghị ịdị irè Ihe mgbochi ACE,
iji belata omume mmepe Ọkụ akwara afọ n’ala (na ọkwa ọnụ, ọ bụrụ na achọrọ ntụgharị ma ọ bụ ịba ọcha n'anya).

Ihe ngbanwe

na allergies n'ihe ndị mejupụtara ya,
na anagideghi lactose,glucose galactose malabsorption syndromema obu enweghi ike lactases,
Ndị mmadụ na-arịa ajọ ọrịa imeju
n'okpuru afọ 18,
na njikọta na Aliskiren,
womenmụ nwanyị dị ime na ndị na-actụ nwa.

Ekwesịrị ịkpachara anya:

na stenosis nke abụọ gbasara akwara ma ọ bụ stenosis akwara (ọ bụrụ na onye ọrịa nwere otu akụrụ)
na-arịa ọrịa oke obi iketumadi na nchikota na gbasara akwara,
naỌrịa ọrịa obi Ischemic ma obu obi arrhythmias,
mgbe amuchara akụrụ,
na mitral ma obu aortic stenosis,
ndị ọrịa nwere ọrịa ụbụrụ, Udeme nke Quincke, gụnyere akụkọ ihe mere eme nke
na mbenata Bcc.

Nsonaazụ

Ọrịa na-abawanye EGO a na-anabata ọgwụ ahụ kpamkpam. Mmeghachi omume ọjọọ bụ ọdịdị dị adị, gafee oge, achọghị ọgwụ iwere ọgwụ.

Ọtụtụ gosipụtara: anya ntughariakpukpo aru orthostatic mmeghachi omume.

nsogbu ịrahụ ụra, isi ọwụwa, asthenia,
palpitations, mgbu obi, adịghị ike, ike ọgwụgwụ, akụkụ azụ,
tachycardiamgbu n'ime mpaghara epigastric,
afọ mgbuọgbụgbọ afọ ọsịsa,
ahu nro, azu mgbu,
rhinitisụkwara sinusitis, pharyngitis na ọrịa ndị ọzọ nke akụkụ okuku ume na elu nke ọrịa na-ebute.

Na ụdị ọrịa shuga 2 akachasikarị: ike adịghị ike, anya ntughari, hyperkalemia, hypotension akwara.

Ugboro na ọdịdị nke mmeghachi omume na-emetụta usoro ịgwọ ọrịa kwa ụbọchị onye ọrịa ahụ na-ewere. Yabụ, mgbe ị na-ewere 150 mg nke Cozaar kwa ụbọchị karịa ugboro ugboro: hyperkalemiaọdịda gbasara akwara, belata EGOmmụba larịị creatininepotassium na urea n’ime ọbara.

N'ime oge ịdebanye aha ọgwụ ahụ, a chọpụtara ihe ndị na-esote mmetụta:

vomiting, imeju ọdịda, ịba ọcha n'anya,
thrombocytopenia, myalgia,
dysgeusia na migraine,
anaemia, arthralgia,
mbelata libido na enweghi ike,
urticariaacha uhie uhie na rashes na akpụkpọ, anụ ahụ anụ ọkụ.

Ntụziaka maka iji Cozaar (usoro na usoro onunu ogwu)

Edere ọgwụ a ọnụ, n'agbanyeghị nri.

Onye dọkịta bịara ya ga-ekpebi usoro onyonyo na usoro a, ebe ọgwụ nwere ike ijikọ ya na ọgwụ ndị ọzọ maka ọbara mgbali elu.

Ntụziaka maka iji Cozaar

Site n'ịbawanye ọbara mgbali elu, usoro izizi = 50 mg kwa ụbọchị.

21bọchị 21-42 gachara ọgwụ malitere, ọgwụ gwọchara arụmọrụ kachasị.

Ọ bụrụ na ọ dị mkpa, enwere ike ịba ụba usoro ọgwụ ahụ ruo 100 mg kwa ụbọchị.

Maka ndị ọrịa na-abawanye EGO soro ya aka ekpe ventricular hypertrophy ma obu ụdị ọrịa shuga 2 usoro onunu ogwu bukwara = 50 mg kwa ubochi (emesiri ya rue na 100 mg).

Ndị mmadụ na- CHF na usoro ọgwụgwọ mbụ, ị nwere ike ị 12ụ ọgwụ ọgwụ 12.5 nke ọgwụ otu ugboro n'ụbọchị. A na-abawanye usoro onunu ogwu kwa ubochi asaa (25 mg, 50 mg, 100 mg na 150 mg) dika onye oria di.

Na ala ọbara na - ekusa(mgbe ewerechara diuretics) Usoro izizi bụ 25 mg kwa ụbọchị.

Ọzọkwa, mmezi dose dị mkpa maka ọrịa ọrịa imeju siri ike.

Dodoụbiga ya ókè

Onweghi ihe akaebe banyere ịdoụ ọgwụ. Echere na ị takingụ nnukwu ọgwụ ọgwụ ahụ ga-eduga nbelata nke ọma EGOna tachycardia.

Dịka ọgwụgwọ, ọ na-eduzi usoro ọgwụgwọ na-akwado ahụ. Ahụ ikeadighi ike.

Mmekorita

Agaghị ejikọ ọgwụ a Aliskirenna ọrịa shuga ma ọ bụ site na akụrụ.

Mgbe agwakọtara nhọrọ ndị na-egbochi COX-2, ọgwụ mgbochi-anaghị egbochi steroidal ya na Losartan ịdị irè nke ìgwè abụọ nke ọgwụ na-ebelata.

Nchikota cozaar na Spironolactone, Amiloride, Triamterenna ndị ọzọ potassium na-eme ka ọnụọgụna-eduga n'ọbara nke potassium n'ime ọbara.

A maara nke ahụ Rifampicin nwee ike belata ịta plasma nke ọgwụ a.

Losartan na-agbagide usoro iwepu lithium n’ahụ.

Na akpachapụ anya, ọgwụ yana PNVS, nke a nwere ike iduga (ọkachasị n’ebe ndị agadi nọ, ndị ọrịa nwere akpịrị ịkpọ nkụ) ịba ụba ibu na akụrụ. A na-atụgharị mgbanwe, na-apụkarị mgbe ịkagbu otu ọgwụ ọ bụla.

Ntụziaka pụrụ iche

Ọgwụ ahụ adịghị arụ ọrụ iji belata ugboro ugboro nkụchi obi maka ndị ọrịa agbụrụ Negroid. N'okwu a, atenolol dị irè karị. Nke a na-eduga ná nkwubi okwu ahụ Ihe mgbochi ACE na ndị anakpo angiotensinọfụma na ndị ọrịa agbụrụ Negroid.

Ogwu a enweghi uche mgbe edere ya hyperaldosteronism, ọ naghị ebelataEGO.

N'ihi eziokwu ahụ bụ na ụfọdụ n'ime mmetụta ndị na-adịghị mma nwere ike imetụta ọsọ na izizi nke mmeghachi omume psychomotor, a na-atụ aro ịkwụsị ịkwọ ụgbọala mgbe ị na-eji ọgwụ ahụ.

Analogs nke Cozaar

Ogwu izizi nwere otutu analogues nwere otutu ihe mejuputara ya:Angizar, Cardomin-Sanovel, Giperzar, Ksartan, Lozap, Closart, Lozartin, Lorista, Losar, Presartan, Pulsar, Erinorm.

Ọzọkwa analogues nke ọgwụ bụ: Advantan, Votum, Aprovel, Vasar, Valsacor, Vanatex, Diovan, Diocor, Irbetan, Candesar, Cantab, Kasark, Mikardis, Teveten, Firmasta, Hizart, Edarbi.

Ngwá ọgwụ nke ọgwụ Cozaar

Mlọ ọgwụ
Angiotensin II bụ vasoconstrictor dị ike, homonụ na-arụ ọrụ nke sistemụ renin-angiotensin na otu ihe dị mkpa na pathophysiology nke ọbara mgbali elu. Angiotensin II na-ekekọta ihe nnabata nke AT1 nke a hụrụ n'ọtụtụ anụ ahụ (dịka ọmụmaatụ, akwara vascular, akaral gland, akụrụ, na obi), ma na-ekpebi ọnụọgụ nke mmetụta ndu dị mkpa, gụnyere vasoconstriction na ntọhapụ aldosterone. Angiotensin II na - akpalitekwa ịbawanye uru akwara dị mma. Na ọnọdụ in vitro na na vivo losartan na ọgwụ ogwu ya na - arụ ọrụ na - arụ ọrụ na - carbonxylic acid (E-3174) na - egbochi mmetụta physiologically pụtara nke anigotensin II na agbanyeghị isi iyi ya. Losartan ahọrọ nke ọma na onye na-anabata AT1, anaghị ejikọ ma ọ bụ gbochie ndị na-anabata homonụ na ụzọ ion. Losartan adịghị egbochi ACE (kininase II), enzyme nke na-akwalite mbibi nke bradykinin. N'ihi ya, nsonye na-emetụtaghị mmechi nke nnabata nke AT1 (dịka ọmụmaatụ, mmụba na mmetụta nke bradykinin) emetụtaghị iji losartan.
Ojiji nke losartan nwere ike belata onwu oke site na ọrịa obi, ọnụ ọgụgụ nke ọrịa strok na infarction myocardial na ndị ọrịa nwere ọbara mgbali elu (mgbali mgbali akwara) na ọbara mgbali ventricular, nwere mmetụta nephroprotective na ndị ọrịa nwere ụdị ọrịa shuga II nke ọrịa mellitus na proteinuria.
Mlọ ọgwụ
Orkpachara anya
Mgbe nchịkwa ọnụ gasịrị, losartan na-agbaso nke ọma ma na-eme metabolism mbụ ya na nguzobe nke metabolic acid na-arụ ọrụ na metabolites na-adịghị arụ ọrụ. The systemic onu bioavailability nke losartan bụ ihe dịka 33%. Ibute oke losartan na metabolite na-arụ ọrụ ya bụ mgbe elekere 1 na awa 3-4 gachara, ị Tụ ọgwụ ahụ na nri anaghị emetụta ịta ahụ losartan na plasma ọbara.
Nkesa
Njikọ nke losartan na metabolite na-arụ ọrụ ya na protein ndị na-edozi plasma, nke kachasị na albumin, karịrị 99%. Olu nkesa - 34 l. Nnyocha ahụ chọpụtara na losartan na-adaghị BBB ma ọ bụ na ọ dịghị abanye ma ọlị.
Mwepu
Mkpochapu Plasma maka losartan na metabolite na-arụ ọrụ ya bụ ihe dịka 600 na 50 ml / min, n'otu n'otu. Mkpochapu nke losartan na metabolite ya na-arụ ọrụ bụ ihe dịka 74 na 26 ml / min, n'otu n'otu. Mgbe nchịkwa ọnụ gasịrị, ihe fọrọ nke nta ka ọ bụrụ 4% nke ọgwụ a na-agbanwegharị na mmamịrị yana ihe dịka 6% nke dose ahụ dị ka metabolite na-arụ ọrụ. Site na nchịkwa ọnụ nke potassium losartan na dose nke ruru 200 mg, ọgwụ ọgwụ nke ọgwụ na metabolite na-arụ ọrụ bụ ahịrị.
Mgbe nchịkwa ọnụ gasịrị, ịta ọgwụ ahụ na metabolites na-arụ ọrụ na plasma ọbara na-agbada nke ukwuu na ọkara ndụ ikpeazụ nke awa 2 maka losartan na awa 6-9 maka metabolite na-arụ ọrụ. Mgbe nchịkwa ọnụ nke C14 kpọrọ akara losartan, ihe dị ka 35% nke redioaktivu na-achọpụta na mmamịrị, 58% na feces.
Pharmacokinetics na otu ọrịa ọrịa pụrụ iche
Ndị okenye na-arịa ọrịa
Sata ahụ nke losartan na metabolite na-arụ ọrụ na plasma ọbara nke ndị agadi nwere ọrịa ọbara mgbali elu (ọbara mgbali elu) adịghị iche na nke ndị ọrịa nwere ọbara mgbali elu (artial pressure) nke ndị okenye.
Okike
Ọbara nke losartan na plasma ọbara dị okpukpu abụọ karịa ndị ọrịa nwere ọbara mgbali elu (ọbara mgbali nwanyị) karịa nke nwanyị. Ntinye uche nke metabolite nọ n'ọrụ n'ime plasma ọbara n'ime ụmụ nwanyị na ụmụ nwoke adịghị iche. Ọdịiche ụlọ ọrụ ọgwụ a abụghị ihe dị mkpa banyere ọgwụ.
Ndị ọrịa nwere ọrịa imeju na akụrụ
Mgbe a na-ewere ya okwu ọnụ na ndị ọrịa nwere ọria mmanya na-egbu egbu na-egbu egbu ruo obere oge, a na-ekpebi ịta ahụ nke losartan na metabolites na-arụ ọrụ na plasma ọbara ugboro 5-1.7, n'otu n'otu, ma e jiri ya tụnyere ndị ọrụ afọ ofufo ụmụ nwoke.
Ntinye uche nke losartan na plasma ọbara n'ime ndị ọrịa nwere nhichapụ ihe karịrị 10 ml / min adịghị iche na nke ahụ ndị nwere ọrụ ezumike nkịtị. AUC na ndị ọrịa na-enyocha hepatialysis dị okpukpu abụọ karịa nke ndị ọrịa nwere ọrụ gbasara mkpo nkịtị. Ntinye uche nke metabolite na-arụ ọrụ na plasma ọbara adịghị agbanwe n’ebe ndị ọrịa nwere ọrụ mkpata na-enweghị ọrụ ma ọ bụ n’arụ ndị ọrịa na-arịa hemodialysis. Losartan na metabolite na-arụ ọrụ ya adịghị ama jijiji site na hemodialysis.

N'oge ime na lactation

Amachibidoro ọgwụ a ịre n'oge nke afọ ime. Ọ ga-agbanwe ya ọgwụ ndị ọzọ antihypertensive.

Ọ bụchaghị ọgwụ a ka a inụ n ’mmiri ara ara. Ya mere, n'oge ọgwụgwọ Cozaar inye ara tụrụ aro ịkwụsị.

Mwepụta wepụtara ya na ihe mejupụtara

Mpempe usoro cozaar - mbadamba ihe eji eme ihe nkiri: mbadamba ọcha, ụdị oval nwere ụdị nkewa nwere akụkụ nkewa ma kpụọ "952" n'akụkụ nke ọzọ, n'ụdị nwere - ịkpụ "960" n'otu akụkụ na elu dị larịị n'akụkụ nke ọzọ (dịka 50 mg maka pcs 14, 100 mg maka 7 ma ọ bụ pcs 14. Na blisters, na ngwungwu kaadiboodu 1 ma ọ bụ blisters abụọ).

Ihe dị n'ọrụ bụ potassium losartan, na mbadamba 1 - 50 ma ọ bụ 100 mg.

Ihe inyeaka: ọka ọka pregelatinized, lactose monohydrate, cellulose microcrystalline, magnesium stearate.

Ihe mejupụtara Shell: hypromellose, hyprolose (ya na 0.3 silicon dioxide), carnauba wax, titanium dioxide.

Ojiji Cozaar di ogwu

Enwere ike iburu Cozaar n'elebara nri anya. Enwere ike ibunye Cozaar n'otu oge iji ọgwụ mgbochi ndị ọzọ.
AH (ọbara mgbali akwara)
Ọgwụ mbụ na usoro eji arụ ọrụ maka ọtụtụ ndị ọrịa bụ 50 mg 1 oge kwa ụbọchị. A na-enweta mmetụta antihypertensive kachasị mma n'ime izu 3-6 site na mmalite ọgwụgwọ. N'ime ụfọdụ ndị ọrịa, iji mepụta nsonaazụ akpọ akpọ, ọ nwere ike ịdị mkpa ka iwelie ọgwụ ahụ ka 100 mg otu ugboro n'ụbọchị.
Mgbe ị na-edepụta ọgwụ ahụ maka ndị ọrịa nwere BCC belatara (dịka ọmụmaatụ, maka ọgwụgwọ yana ị doụ nnukwu mgbatị), ọgwụ mbụ nwere ike ịbụ 25 mg otu ugboro kwa ụbọchị (lee AKSTRUCTIONKỌ AK SPKỌ BECBARA).
Enweghị mkpa ịhọrọ usoro izizi maka ndị ọrịa agadi ma ọ bụ ndị ọrịa nwere ọdịda gbasara ọrịa, gụnyere ndị ọrịa na hemodialysis. Enwere ike inye ndị ọrịa nwere ọrịa imeju obere obere karịa oge ọ bụla.
Iji belata ihe egwu na nsogbu maka ihe kpatara ọrịa obi na ndị ọrịa nwere ọbara mgbali elu (hypertension) na mgbali ventricular.
Ọgwụ mbụ Cozaar na-agbakarị bụ 50 mg 1 kwa ụbọchị. Dabere na mgbanwe ọbara ọgbụgba, a na-eji mmiri ọgwụ hydrochlorothiazide ọzọ na / ma ọ bụ na-eme ka Cozaar na-abawanye ruo 100 mg otu ugboro n'ụbọchị.
Nephroprotection na ndị ọrịa nwere ụdị ọrịa shuga nke II nke nwere proteinuria
Ọgwụ mbụ a na-ebido bụ 50 mg otu ugboro kwa ụbọchị. Enwere ike ịbawanye ọgwụ ahụ na 100 mg otu ugboro kwa ụbọchị, dabere na mgbanwe mgbanwe ọbara mgbali. Enwere ike ịnye Cozaar n'otu oge yana ọgwụ ndị ọzọ antihypertensive (diuretics, ndị na-egbochi calcium, α- ma ọ bụ β-adrenoreceptor blockers na ọgwụ ndị na-eme ihe), yana insulin na ọgwụ hypoglycemic ndị ọzọ ejirila (dịka eg sulfonylureas, glitazones na glucosidase inhibitors).

Mmekorita nke Cozaar nke ogwu

N'ime ọmụmụ ọgwụ pharmacookinetic, ọ nweghị mmekọrịta dị oke mkpa nke losartan nwere hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital, ketoconazole na erythromycin. A kọwo Warfarin na fluconazole na-agbadata ọkwa nke metabolite na-arụ ọrụ nke losartan. Agabatabeghị ọgwụgwọ ọrịa mmekọrịta ndị a.
Dị ka ọ dị ndị ọzọ na-egbochi angiotensin II, ojiji a na-ejikọ ya na mmiri ọgwụ (spirinolactone, triamteren, amiloride) nke nwere ihe na-akpata potassium, nwere ike ibute hyperkalemia.
Ndị NSAID, gụnyere ndị na-egbochi COX-2 na-egbochi, nwere ike belata nsonaazụ diuretics na ọgwụ ndị ọzọ na-egbochi mmiri. Ya mere, mmetụta antihypertensive nke ọgwụ ọjọọ - angiotensin II receagonor antagonists nwere ike belata site na iji NSAID n'otu oge, gụnyere ndị na-egbochi COX-2.
N'ime ụfọdụ ndị ọrịa nwere ọrụ mgbazinye nsogbu na ọgwụgwọ nke NSAIDs (gụnyere ndị na-egbochi COX-2), njikwa ọnụ nke ndị na-emegide ndị nnabata angiotensin II nwere ike ibute mbelata ọrụ ọrụ na nha. A na - atụgharị mmetụta ndị a.

Nyocha maka Cozaar

Na forums na thentanetị banyere ọgwụ ọjọọ na-ekwu okwu nke ọma. Site na nhazi usoro, ọgwụ a na - eme ka ọ̀tụ̀tụ̀ ọbara ji erugharị ókè ma ghara inwe mmetụta ndị ọzọ. Ọ dị mma, oriri ya na nri oriri adịghị.

Nyocha banyere Cozaar:

"Ọgwụ nkịtị, ma ọ nyeghị aka ozugbo, kama ọ bụ naanị ebe dị ka izu nke 3 nke nchịkwa",

“Mgbe a wasịrị m ahụ, m na-a Coụ Cozaar otu izu. Nrụgide belatara site na 220 116 ruo 130 87. Mmetụta dị n'akụkụ bụ adịghị ike, mana m na-emehie na usoro izizi. Tupu m nwaa ọgwụ ndị ọzọ - ha enyereghị m aka. ”

Mlọ ọgwụ

Mgbe a na -ekwu ya ede, losartan na-etinye obi gị dum ma na-eme ya nke ọma. Ejiri ya na nsonaazụ nke "ụzọ mbụ" site na imeju na ịmepụta nguzo nke hydroxylated metabolites na ọrụ ọgwụ, yana metabolites na-adịghị arụ ọrụ. Sistemụ bioav adị nke ihe dị n'ụdị mbadamba ihe dịka 33%. Edekọtara mkpokọta kachasị nke losartan na metabolite na-arụ ọrụ na nkezi mgbe awa 1 na awa 3-4 gachara nchịkwa. Mgbe ị na-eri Cozaar n'oge nri ọkọlọtọ, ntinye uche nke ihe ndị mejupụtara n'ọbara plasma na-agbanwe agbanwe.

Ogo ogo nke losartan na metabolite na-arụ ọrụ ya na protin plasma (ọkachasị ya na albumin) ruru 99%. Olu nke nkesa losartan bu lita 34. Nnyocha ndị mere pụta gosiri na ihe mgbochi ụbụrụ ọbara dị n'ihe ahụ.

Odika 14% nke Cozaar, mgbe a na -ewere ya ọnụ ma ọ bụ n’olu, gafere metabolite na-arụ ọrụ ya. Na mgbakwunye na ya, achoputara metabolites na-adịghị arụ ọrụ metabolites, n'etiti nke 2 metabolites dị ukwuu na-achịkwa, bụ nke etolite n'ihi hydroxylation nke akụkụ butyl yinye, yana otu metabolite abụọ - N-2-tetrazole-glucuronide.

Mkpochapụ plasma nke ihe Cozaar na-arụ ọrụ na metabolite ya na-arụ ọrụ bụ ihe dịka 600 ml / min na 50 ml / min, n'otu n'otu. Nwepụ nke mkpokọta ogige ndị a bụ ihe dịka 74 ml / min yana 26 ml / min, n'otu n'otu. Site na nchịkwa ọnụ nke losartan, ihe dị ka 4% nke ọgwụ aewere na-agbanwe na mmamịrị yana ihe dị ka 6% nke dose ahụ na-apụ apụ n'otu ụzọ ahụ n'ụdị metabolite nọ n'ọrụ. Maka losartan na metabolite na-arụ ọrụ, linearity nke ọgwụ pharmacokinetic nwere nchịkwa ọnụ nke Cozaar na doses ruo 200 mg bụ njirimara.

Mgbe nchịkwa ọnụ gasịrị, ọdịnaya nke losartan na metabolite na-arụ ọrụ na plasma na-ebelata nke ukwuu, na ọkara ndụ ikpeazụ nke ihe dịka awa 2 na 6-9, n'otu n'otu. Mgbe ị na-ewere Cozaar na usoro onunu ogwu nke 100 mg otu ugboro kwa ụbọchị, ahụghị mkpo losartan ma ọ bụ metabolite na-arụ ọrụ n'ime ahụ. A na-eme mkpụcha nke losartan na metabolites ya na-arụ ọrụ site na akụrụ, yana site na eriri afọ ya. Mgbe nchịkwa ọnụ nke losartan mara akara 14 C, n'ime ndị ọrịa ụmụ nwoke, ihe dịka 35% nke isotope redioaktivu na-ahụ na mmamịrị, yana 58% na feces. Site na nchịkwa intravenous nke 14 C nke losartan, ihe dị ka 43% nke redioacacacacia na-ekpebi na mmamịrị ma 50% na feces.

Plasma losartan ọkwa n'ime ụmụ nwanyị nwere ọbara mgbali elu ruru ugboro abụọ karịa ụmụ nwoke nwere otu ọnọdụ. Theta ahụ metabolite nọ n'ọrụ na ndị ọrịa nke nwoke na nwanyị inwe ihe fọrọ obere. Agbanyeghị, ihe ịtụnanya a enweghị ihe ọria.

N'ime ndị ọrịa nwere ọria ị alcoụ mmanya na-egbu egbu na obere nchịkwa nke Cozaar, ọdịnaya nke losartan na metabolite na-arụ ọrụ na plasma ọbara dị elu 5 na 1.7 karịa, karị, karịa ụmụ nwoke na-eto eto nwere ahụike ji aka wepụta onwe ha na nnwale ahụ.

Ntụziaka maka iji Cozaar: usoro na usoro onunu ogwu

A na-ewere ọnụ ọnụ cozaar ọnụ otu ugboro n'ụbọchị, n'oge ọ bụla dabara adaba, n'agbanyeghị nri.

Ọ bụ dọkịta na-ahụ maka ị basedụ ọgwụ ọ basedụ basedụ ahụ dabere na ngosipụta nyocha nke ụlọ ọgwụ.

Usoro akwadoro nke usoro Cozaar:

Ọbara mgbali akwara: 50 mg dị ka ọgwụ mbido na mmezi, ọ bụrụ na ọ dị mkpa, iji rụpụta nsonaazụ ka ukwuu, enwere ike were 100 mg. Mmetụta hypotensive kwụ ọtọ na-apụta mgbe izu 3-6 nke ọgwụgwọ gasịrị. Maka ndị ọrịa nwere BCC belatara, a na-atụ aro mbido ọgwụ ahụ na ọnụọgụ 25 mg. Ọ bụrụ na e gosipụtara akụkọ banyere ọrịa ọrịa akwara, ị shouldụ ọgwụ ahụ kwesịrị ibelata. Ndị ọrịa nke afọ agadi na akwara gbasara akụrụngwa, gụnyere ndị ọrịa on diaals, anaghị achọ ndozi ọgwụ usoro mbụ.
Ọrịa obi na-adịghị ala ala: mkpụrụ ọgwụ mbụ bụ 12.5 mg, a na-atụ aro titration otu ugboro n'izu, na-ewetara onye na-elekọta ya (12.5 mg, 25 mg ma ọ bụ 50 mg),
Elldị nke abụọ nke ọrịa shuga mellitus nwere proteinuria: usoro mbụ bụ 50 mg, na-eburu n'uche mbelata ọbara mgbali elu (BP), a ga-eji nwayọ bulie ya ruo 100 mg. Mkpokọta ojiji nke ọgwụ ahụ na diuretics, alfa na beta adrenoblockers, calcium channel blockers, Central na-eme ọgwụ, ndị ọzọ hypoglycemic elekọta mmadụ (glitazones, sulfonylureas, glucosidase inhibitors) na insulin,
Ọbara mgbali akwara na ọnya ọgbụgba ventricular aka ekpe: Usoro izizi iji belata ọrịa ọrịa obi na ịnwe anwụ bụ 50 mg. N'inye ogo ogo mbelata ọbara mgbali elu, usoro ọgwụgwọ ọzọ na-agụnye ịba ụba nke dose ka 100 mg ma ọ bụ ịkọwa usoro nke hydrochlorothiazide dị ala.

Nsonaazụ

Nyocha ndị ụlọ ọgwụ a na-achịkwa banyere Cozaar, a rụpụtara mmetụta ndị na-esote:

Site na sisitemu obi: tachycardia, palpitations,
Site na sistem iku ume: ọzịza nke mualsa imi, ụkwara, ọrịa akụkụ okuku ume na ala, pharyngitis, sinusitis,
Site na usoro digestive: ọgbụgbọ, dyspepsia, afọ ọsịsa,
Site na usoro ụjọ ahụ: ehighị ụra nke ọma, isi ọwụwa, isi nri,
Site na usoro mọzụlụ: olu mgbu, azụ mgbu,
Site na anụ ahụ n'ozuzu ya: ike ọgwụgwụ na adịghị ike, mgbu n'ime obi na / ma ọ bụ afọ, ọzịza,
N'akụkụ nke ụlọ nyocha: hyperkalemia (ọkwa dị elu nke alanine aminotransferase mgbe iwere ọgwụ na-apụtakarị na nkịtị).

Mmeghachi omume ọjọọ na nchịkwa Cozaar kwuru na usoro ọgwụgwọ dị obosara:

Usoro nri: ọrụ imeju na-arụ ọrụ, ọria ịba ọcha n'anya.
Usoro nke Hematopoietic: thrombocytopenia, anaemia,
Usoro akwara: arthralgia, myalgia, adịkarịghị - rhabdomyolysis,
Usoro ụjọ: migraine, dysgeusia adịkarịghị,
Usoro akụkụ okuku ume: ụkwara,
Mmeghachi omume oria: itching, urticaria, flushing skin,
Mmeghachi omume nfụkasị: ọ na - adịkarịghị - vasculitis, ọrịa Shenlein-Genoch, angioedema, gụnyere mbufụt nke glottis, larynx, nwere ihe mgbochi nke akụkụ iku ume, yana / ma ọ bụ mkpịsị nke egbugbere ọnụ, ihu, ire na / ma ọ bụ pharynx (ụfọdụ n'ime ndị ọrịa ahụ nwere mmeghachi omume hyperensitivity site na iji dose gara aga. Ihe mgbochi ACE).

Na mkpokọta, Cozaar na-anabata nke ọma, nsonaazụ ya na-adịte aka ma na-egosipụta n ’ụdị dị nwayọ nke anaghị achọ ịkwụsị ọgwụ.

Emere ọgwụ nke Cozaar

Ntụziaka a nyere Cozaar na-egosi na ọgwụ a nwere ike belata akwara akwara, na-enwe oke mgbali ọbara na-erugharị, ọbara ọgbụgba, na-ebugharị, ma na-enwekwa ọria diuretic.

Na mgbakwunye, dị ka nyocha si Cozaar gosipụtara, ọgwụ a anaghị ekwe ka ọnọdụ nke hypertrophy myocardial. Maka ndị ọrịa nwere nkụchi obi, a na-enye Cozaar maka inyefe mmega ahụ ka mma.

Dabere na nyocha banyere Cozaar, ị theụ ọgwụ ahụ naanị oge 1, mgbe awa 6 gachara, systolic na ọbara mgbali belata. Mmetụta yiri nke ahụ na-adịgide ruo awa 24. Usoro ọgwụgwọ ị withụ ọgwụ ahụ iji rụpụta nsonaazụ kacha mma ekwesịghị ịbụ ihe na-erughị izu 3-6.

Usoro onunu ogwu na nhazi

Dika ekwuru na ntuziaka nye Cozaar, a na-a takenụ ọgwụ tupu, mgbe ma ọ bụ mgbe nri ahụ gasịrị. Maka ọgwụgwọ nke otu ọrịa, naanị Cozaar ka enwere ike iji ya ma ọ bụ enwere ike ijikọ ya na ọgwụ ndị ọzọ na-alụ ọgụ ọbara mgbali elu.

Ọ bụrụ na onye ọrịa na-arịa ọbara mgbali elu, ekwesịrị ịmalite ọgwụgwọ Cozaar site na iji ọgwụ nke 50 mg na-erughị 1 oge kwa ụbọchị. Mmetụta kachasị mma nke ị thisụ ọgwụ a pụtara izu 3-6 mgbe ojiji nke ọgwụ mbụ. Ọ bụrụ na ọ dị mkpa, dọkịta nwere ike ịbawanye usoro ọgwụ kwa ụbọchị ruo 100 mg (oge 1 na awa 24).

Na nyocha nke Cozaar, egosiputara na ndị ọrịa nwere oke ọbara na-agagharị agagharị kwesịrị ịmalite ọgwụgwọ were ọnụọgụ ọgwụ 25 mg naanị 1 oge kwa ụbọchị.

Ndị okenye, yana ndị ọrịa enweghị ụkọ akwara, bụ ndị ka na-arịa ọrịa akwara, anaghị achọ mgbanwe iji usoro ọgwụgwọ egosipụtara na ntuziaka ahụ na Cozaar.

Ekwesịrị ka enye ndị ọrịa nwere oke ịba ọcha n'anya Cozaar belata obere ụbọchị.

Ijibelata ọrịa nke metụtara ọrịa obi, yana belata ọnwụ na ndị nwere ọbara mgbali elu aka ekpe na ọbara mgbali elu, maka ndị ọrịa niile, na-enweghị mgbakwunye, usoro ọgwụ nke 50 mg nke Cozaar ka edepụtara ọ bụla karịa 1 oge n'ime awa 24. Nyocha banyere Cozaar na-egosi na mgbe oge ụfọdụ gasịrị, dọkịta ahụ na-atụkwa obere ọgwụ hydrochlorothiazide, ma ọ bụ na ị nwere ike iwelie oriri Cozaar nke ukwuu (ihe ruru 100 mg otu ugboro n'ụbọchị). N'okwu a, ọ dị mkpa iburu n'uche ihe ngosipụta nke belata ọbara mgbali elu.

Iji kwado ọrụ akụrụ dị mma na ndị ọrịa nwere ụdị shuga na proteinuria, ekwesịrị ịmalite iji ọgwụ nke 50 mg otu ugboro kwa ụbọchị. Mgbe nke a gasịrị, iji Cozaar kwa ụbọchị na-abawanye ruo 100 mg, mgbe ị na-eleba mbelata ọbara mgbali elu. Enwere ike ijikọ ọgwụ a nyochara na insulin, diuretics, ndị nnọchi etiti, yana ọgwụ hypoglycemic dị iche iche.

Ọ bụrụ na onye ọrịa na-arịa ọrịa obi na-adịghị ala ala, ọgwụ mbụ nke Cozaar enweghị ike karịa 12.5 mg n'oge ụbọchị, nke a na-aga n'ihu kwa ụbọchị n'izu mbụ nke ọgwụgwọ. N'izu nke abụọ, usoro onunu ogwu a na-abawanye ruo 25 mg kwa ụbọchị, n'ọkwa nke atọ - ruru 50 mg kwa ụbọchị.

Ngwakọta na ụdị ntọhapụ

Usoro onunu ogwu 25 nwere ihe dika 25 mg nke potassium losartan. Mbadamba ọcha ọ bụla bụ nke oval, nke nwere ihe nkiri, nke akara 951 dị n'otu akụkụ.

Mbadamba ọgwụ nwere ọgwụ iri ise dị iche na ọgwụ 25 na-esighị ike site na ịbe ya na ego nke ihe na-arụ ọrụ na 50 mg nke losartan potassium. Mkpụrụ ọgwụ ọ bụla na-acha ọcha nwere otu oval, ihe mkpuchi na ya, akara akara 952

Mbadamba ọgwụ ndị nwere ọnụọgụ ọgwụ grasa 100 nke losartan nwere ọdịdị pill na-acha ọcha n'ụdị dobe nwere akara 960

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Ọmụmụ ihe iji chọpụta mmetụta nke Cozaar na ike ịkwọ ụgbọala na ịrụ ọrụ na usoro mgbagwoju anya emebeghị. Agbanyeghị, mgbe ị na - eme ọgwụ antihypertensive, a na - adụ ọdụ mgbe ị na - akwọ ụgbọala ma ọ bụ na - arụ ọrụ nwere ike ịdị mkpa chọrọ ịbawanye ụba na mmeghachi omume psychomotor ozugbo. Ejikọtara nke a na ihe isi ike nke akpịrị ịkpọ nkụ na iri ụra mgbe ị na-a drugụ ọgwụ, karịsịa na mmalite nke ọgwụgwọ ma ọ bụ na-abawanye na dose.

Andzọ na njirimara ngwa

A na-eji Cozaar agbanyeghị oge nri, ọ dị naanị mkpa iji gbasoo ụzọ a họọrọ isi were mbadamba ụbọchị niile. Ntụziaka ahụ na-atụ aro ị swallowụ ọgwụ n'iwe mmiri.

Dabere n’ọnọdụ onye ọrịa ahụ, a na-ahọrọ ọgwụ achọrọ kwa ụbọchị. Ihe nmalite mbu bu itinye ogwu nke Cozaar 50 ma obu 100 n’ime awa iri n’abuo. Ọnọdụ ndị na-edekọ ntakịrị ị lowerụ ọgwụ ahụ na 25 mg kwa ụbọchị ka amaara. Soro ntuziaka maka ojiji ịghara ịgafe 100 mg na awa 24. Onu ogwu g’eme ka ndi dibia bekee mara.

A na-agbakọ ụkpụrụ ọkọlọtọ maka ndị ọrịa si afọ isii ruo afọ iri na isii dabere na ogo ahụ nwatakịrị.

20-49 n'arọ nke iwu ị theụ ọgwụ bụ 25mg kwa ụbọchị, enwere ike ịbawanye 50 mg maka otu ọgwụ kwa ụbọchị.
50 n'arọ na karịa - 50 mg kwa ụbọchị, nwere ike ịba ụba na 100 mg kwa ụbọchị.

Enweghị mkpa ịgbanwe usoro mmalite maka ndị ọrịa nwere ọdịda akụrụngwa na ndị nọ n'ọrịa hemodialysis.

Ọ bụrụ na enwere mmebi nke ikejuju na akụrụngwa nke ahụike nke onye ọrịa, a ga-atụle nke ga-agbadata obere usoro.Ahụmịhe ogwu gosipụtara n'ụzọ dị mma na ojiji nke Cozaar ọgwụ na ndị ọrịa nwere nnukwu akụrụ siri daa, ya mere, atọrọ ọfụma ndị otu a.

N'ime ndị ọrịa karịrị afọ 75, enwere ike ịtụle usoro mbụ nke 25 mg, ọ bụ ezie na idozi dose adịghị adịkarị mkpa maka ndị ọrịa a.

Ime na lactation

Dabere na ntuziaka ahụ, a machibidoro Cozaar iwu ka ọ tụrụ ime n'oge ime. Drugsụ ọgwụ ogwu n’oge nke II na III nke afọ ime na-emetụta sistemụ angninensin nwere ike bute oke ntụpọ ma ọ bụ ọbụna ọnwụ nke nwa ebu n’afọ na-etolite, ya mere, ọgwụ a ga-akagbu ozugbo o gosipụtara eziokwu na ịtụrụ ime. Mpempe mmerụ ahụ na -eme ka mmepe nke usoro renin - angiotensin na - aputa n'ime nwa ebu n'afọ na ọkara nke abụọ. Ihe ize ndụ dị n’ebe nwa ebu n’afọ nọ na-abawanye ma ọ bụrụ na ewere Cozaar n’oge nke abụọ ma ọ bụ atọ nke afọ ime.

A naghị akwado ọgwụgwọ Cozaar n'oge ị na-enye nwa ara. Ahụmahụ nke iji losartan na ụdị ndị ọrịa a ezughi, a maghịkwa ma ihe ahụ ọ̀ banyere n'ime mmiri ara. Yabụ, ọ dị mkpa ịkọwa uru ọrụ ọgwụgwọ dịịrị nne na ihe ọghọm ndị ọ bụla nwere ike ịbara nwa ahụ ma kpebie nkwụsị nke inye nwa ara ma ọ bụ mwepụ nke Cozaar.

Mkparịta ụka ọgwụ ọjọọ

Mmekorita di egwu nke Cozaar nwere dika digoxin, warfarin, hydrochlorothiazide, cimetidine, ketoconazole, phenobarbital, erythromycin.

Emebeghị ka uto nke mbelata nke ihe na-eme ihe ma na-ewere fluconazole na rifampicin na ogwu a.

Nlekọta oge nke potassium mmeju, triamteren, spironolactone, amiloride na ọgwụ ndị ọzọ na-egbochi ihie angiotensin nke abụọ, nnu nwere potassium, nwere ike inye aka na-abawanye na ọkwa nke potassium na ọbara.

Mgbe ejikọtara ya na nhazi lithium, losartan na-ebelata excretion ma na-eme ka itinye uche ya dịkwuo elu.

Ọgwụ mgbochi steroidal anti-inflammatory (NSAIDs), ndị na-egbochi cyXlooxygenase inquitors COX-2 cyclooxygenase na -ebilata mmetụta hypotensive nke ọgwụ ahụ.

N'ime ndị ọrịa nwere ọrụ mgbazinye nsogbu, iji ọgwụ a eme ihe na NSAIDs, gụnyere ndị na - egbochi COX-2 inhibitors, nwere ike ịbawanye ọrụ ezumike. Mmetụta nke mmekọrịta a na-atụgharị.

Mbelata nke ume plasma nke metabolite na-arụ ọrụ n'oge eji fluconazole na njikọ Cozaar na-eme ka ịba ụba nke losartan na plasma ọbara.

Ihe analogues Cozaar bu: Blocktran, Lozap, Losartan, Lorista, Angizar, Kardomin-Sanovel, Giperzar, Ksartan, Klosart, Lozartin, Losar, Presartan, Pulsar, Erinorm, Advantan, Votum, Aprovel, Vazar, Valsacor, Vanatex, Vanatex Irbetan, Candesar, Cantab, Kasark, Mikardis, Teveten, Firmasta, Hizart, Edarbi.

Iji Oge ime

Womenmụ nwanyị dị ime ekwesịghị iburu Cozaar n'ihi na ị theụ ọgwụ ahụ nwere ike ịdị ize ndụ maka nwa ebu n'afọ. Ọ bụrụ n’ịkpa ime ịtụrụ ime, kpọtụrụ dọkịta gị ọgwụ ndị ọzọ ị nwere ike ị ga - eme iji chịkwaa ọbara mgbali elu gị. Ọ bụrụ na ime amalite mgbe ị na-a theụ ọgwụ, kwusi usoro ọgwụgwọ ozugbo ma chọọ ndụmọdụ ahụike.

Amaghi ma losartan banye n’ime mmiri ara. N’inye ihe egwu nke imetụta ndị ọrịa ụmụaka na-erubeghị afọ 6, ịkwesịrị ịkwụsị inye nri maka oge iji ọgwụ ahụ.

Ọnọdụ nchekwa

Debe ọgwụ ahụ ka anwụ ghara ịdị ya site na okpomọkụ mgbe ọ na-akarịghị ogo 30 Celsius n'ebe ụmụ na anụmanụ na-enweghị ike inweta ya.

Mbadamba nke ọ bụla na-ejigide 25, 50, ma ọ bụ 100 mg nke potassium losartan na-arụ ọrụ. Dika ihe ndi ozo, microcrystalline cellulose na hydrated lactose, stgelatinized starch, magnesium stearate na hydroxyproxy cellulose na hydroxyproxy methyl cellulose, titanium dioxide, carnauba wax eji.