Sandostatin: ngosipụta maka iji ya na pancreatitis

Nkọwa nke metụtara 05.08.2015

Aha Latin: Sandostatin
Koodu ATX: H01CB02
Arụ Ọrụ: Octreotide
Emeputa: Novartis Pharma (Switzerland)

1 ml nke ihe ngwọta maka nchịkwa iv na s / c nwere 50, 100 ma ọ bụ 500 μg nke ihe na-arụ ọrụ octreotide.

1 vial nke microspheres maka nkwadebe nke nkwusioru maka nchịkwa m / m Sandostatin Lar nwere 10 mg nke akụrụngwa nọ n'ọrụ n'ụdị. octreotide acetate.

Usoro onunu ogwu na nhazi

Edere Sandostatin ndị ọrịa ka ọ gwachara akwara nke ọrịa pancreatitis. Ọgwụ a na-ebelata mmerụ ahụ, ebe ọ bụ na mbelata na ịmepụta enzymes na-akwụsị usoro mbibi anụ ahụ.

N'ụdị ọrịa pancreatitis na-adịghị ala ala, Sandostatin na-eme ka ọnọdụ ndị ọrịa dịkwuo mma, na-enyere aka belata ọnụ ọgụgụ nke ihe ọdịdọ. A na-enye Sandostatin n'ime ampoules ndị ọrịa subcutaneously, intramuscularly, intravenously site infusion ugboro atọ n'ụbọchị. A na-eme ntụpọ n'etiti nri na tupu alakpu ụra. Nmebata nke Sandostatin bụ otu awa tupu arụ ọrụ ahụ yana n’ime ụbọchị asaa mgbe ọ nwụsịrị. Ọ bụ dọkịta na-ahụ maka ịga ọgwụ ka usoro ọgwụ a ga-esi dozie ya, n'otu n'otu dabere n'ụdị ọrịa ahụ. Ọgwụ na-amalite ime 5 nkeji mgbe mmalite nke infusion.

Nsonaazụ

Site na usoro ọgwụgwọ Sandrostatin, enwere ike ịme mmetụta. Site na eriri afọ, ọgbụgbọ, ọgbụgbọ, ọgbụgba ọnya, flatulence, cholecystitis, ọdịdị nke okwute na ọnya biliary, mmụba nke ọdịnaya bilirubin na enzymes imeju na ọbara, na ọnya afọ ga-ekwe omume. Ọ nwere ike ịbụ ọrịa obi, akwara na ọrịa endocrine:

hypothyroidism (ezughi oke nke ọrụ thyroid),
metabolic ọrịa nke glucose na ahu,
bradycardia (olu nwayọ nwayọ),
obi palp,
isi ọwụwa.

Na anabataghị mmiri nke Sandostatin, mmeghachi omume nfụkasị nwere ike ime.

Mmekọrịta na ọgwụ ndị ọzọ

N'iji nlezianya, Sandostatin kwesịrị iji ya mee ihe na njikọta beta-mgbochi yana ọgwụ diuretic. Mgbe ejikọtara ya na cyclosporine, mmetụta nke ikpeazụ na-ebelata. Ejiri akpachapụ anya kọchaa Sandostatin nwere insulin. N'okwu a, ọ dị mkpa ịchịkwa glucose ọdịnaya ọbara. Sandostatin na-ebelata nnabata nke cimetidine. Anabataghị ikike mmanya na-egbu egbu. Ọgwụ anaghị enwe mmetụta n’ịkwọ ụgbọala.

Ngwakọta na ụdị ntọhapụ

Ihe na-arụ ọrụ nke ọgwụ ahụ bụ octreotide, nke bụ analog synthetic analog nke homonụ somatostatin. A na-ewepụta ọgwụ ahụ n'ụdị ihe nrịba ama (ampoules) ma ọ bụ lyophilisate, nke a na-akwado ihe ọ bụla.

Otu ampoule nwere olu nke 1 ml nwere ọgwụ 0.05-0.1 mg nke ihe na-arụ ọrụ. Na mgbakwunye na usoro emechara, a na-emepụta ọgwụ ahụ n'ụdị ntụ ntụ, nke a na-agwakọta tupu eji ya na ntinye uche chọrọ.

Mwepụta wepụtara ya na ihe mejupụtara

Dodị usoro ịhapụ Mịkị Sandostatin bụ ihe ngwọta maka nchịkwa intravenous na subcutaneous: na-enweghị ụcha, na-acha ọcha (na ampoules nke 1 ml, na mkpọ kaadi nke 5 ampoules 5 ma ọ bụ 10).

Ngwakọta nke 1 ml nke ihe ngwọta:

ihe na-arụ ọrụ: octreotide (dị ka peptide n'efu) - 50, 100 ma ọ bụ 500 μg,
ihe ndi ozo: sodium bicarbonate, lactic acid, mannitol, carbon dioxide, mmiri maka injection.

Mlọ ọgwụ

Ihe na-arụ ọrụ nke Sandostatin bụ octreotide - octapeptide sịntetik, ntụnyere nke homonụ nke mkpụrụ ndụ sitere na somatostatin, nke nwere mmetụta ọgwụ ọgwụ yiri nke ahụ, mana ogologo oge dị oke ogologo.

Octreotide na - egbochi ọnya hormone nke na - eto eto (GH), ha abụọ mụbara ma na - ebilite n'ihi insulin hypoglycemia, mmega ahụ, yana ikpughe arginine. Sandostatin na - egbochikwa ịmịnye insulin, serotonin, gastrin na glucagon, mụbara nje ma ọ bụ n'ihi nri nri. Na-egbochi mmiri nzuzo nke glucagon na insulin na-akpali site na arginine, yana nzuzo nke thyrotropin nke thyroliberin kpatara.

N'adịghị ka somatostatin, octreotide na-egbochi nzuzo nke GR ruo n'ókè karịrị nnabata insulin. Ọgwụ a adịghị eduga na hyperecretion na-esochi nke homonụ (dịka ọmụmaatụ, homonụ na-eto eto na ndị ọrịa nwere acromegaly). Site na acromegaly, Sandostatin na-ebelata ọkwa plasma nke GH na insulin-like factor development (IGF-1). N'ime 90% nke ndị ọrịa, enwere mbelata mkpokọta nke GH site opekata mpe 50%, ebe enwere ike nweta ọkwa GH n'okpuru 5 ng / ml n'ihe dị ka 50% nke ikpe. N'ime ọtụtụ ndị ọrịa nwere acromegaly, ọgwụ na-ebelata ọzịza nke anụ ahụ dị nro, ogo isi ọwụwa na hyperhidrosis, paresthesia na mgbu nkwonkwo. Site na adenomas buru ibu, Sandostatin nwere ike belata obere akpụ ahụ.

Octreotide nwere ike imeziwanye ọrịa ahụ ma ọ bụrụ na ezughi oke nke usoro ọgwụgwọ (hepatic artery embolism, ịwa ahụ, kemotemosis, gụnyere 5-fluorouracil na streptozotocin) nke mkpụrụ ndụ endocrine mbufụt nke eriri afọ na akwara. Yabụ, na ọnya ọnya ọnya, Sandostatin na-ebelata oke ọnya afọ na mmetụta nke iwepụ ihu, nke na-esokarị mgbada plasma nke serotonin na mpụta nke 5-hydroxyindoleacetic acid na mmamịrị. Site na etuto VIP na hyperproduction nke vasoactive intestinal peptide (VIP), ọgwụ ahụ na-ebelata oke ọgbụgba na -akpata ma, n'ihi ya, na-eme ka ndụ onye ọrịa dịkwuo mma. N'otu oge ahụ, a na-ebelata ọgba aghara na elektrolyte (dịka ọmụmaatụ, hypokalemia), nke na-eme ka o kwe omume ịkagbu nchịkwa parenteral na enteral nke electrolytes na mmiri. N’ebe ụfọdụ ndị ọrịa nọ, Sandostatin na-akwụsịlata, ọbụnadị akwụsịkwa ito ahụ, na-ebelata oke ya, yana oke nke metastases imeju. Mmalite ahụike na-adakarị, dịka iwu si dị, na-esobelata ma ọ bụ ịhazi usoro ịta plasma nke VIP.

Na glucagonomas, octreotide na-ebelata erythema migrans. N'ime ọrịa shuga mellitus, ọgwụ adịghị emetụta ogo ịba ụba hyperglycemia, yabụ mkpa ọ dị maka ndị na-ahụ maka hypoglycemic ma ọ bụ insulin na-agbanwekarị. N'ihi mbelata afọ ọsịsa, mmụba n’arụ ahụ ga-ekwe omume. Na agbanyeghi na mbelata plasma nke glucagon n'okpuru Sandostatin dị mkpụmkpụ na okike, mmelite na ọnọdụ ụlọ ahụ kwụ chịm oge niile ị theụ ọgwụ.

Na ọrịa gastrinomas / Zollinger-Ellison syndrome, iji octreotide dị ka otu ọgwụ ma ọ bụ jikọtara ya na ndị na-egbochi histamine H.₂Ndị na-egbochi mmiri ma ọ bụ ndị na-egbochi protin nke proton nwere ike ibute mbelata nke hydrochloric acid na afọ, mbelata mkpokọta nke gastrin na plasma ọbara na ogo nke ọkụ na-ekpo ọkụ na afọ ọsịsa.

N'ime ndị ọrịa nwere insulinomas, Sandostatin na-enyere aka belata insulin immunoreactive insulin n'ime ọbara (mmetụta a nwere ike ịbụ obere oge, ruo awa 2). Na ọnụnọ nke akpụ akpụ, ọgwụ nwere ike iweghachi ma na-edozi normoglycemia n'oge mkpado. Site n'ọrịa ịba uru na ọnya ọjọọ, njikwa glycemic nwere ike ịbawanye n’anweghị mgbatị insulin na ọbara n’otu oge.

N'ime ndị ọrịa nwere nnukwu ahụrịrị nke na-ebute ihe na-eme ka mkpụrụpụta hormone na-etopụta ihe (somatoliberinomas), Sandostatin na-ebelata ogo mgbaàmà acromegaly, ebe ọ na - egbochi ihe nzuzo nke na - eme ka hormone na - eto uto ya. N’ọ n’ihu, mbelata nke puruwuru nke puruwuru pụtakwara ọgwe omume.

Mgbe ọbara ọgbụgba sitere na varicose veins nke esophagus na afọ n’ime ndị ọrịa nwere ọrịa cirrhosis, mgbakwunye nke octreotide na usoro ọgwụgwọ akọwapụtara (dịka ọmụmaatụ, sclerotherapy) nwere ike ịkwụsị ọbara ọgbụgba ma gbochie ịmalite ọbara ọgbụgba, belata mmịnye ọbara ma mee ka ụbọchị 5 dịkwuo mma. Ekwenyere na usoro nke Sandostatin bụ n'ihi mbelata ọbara anụ ahụ n'ihi mkpochapụ homonụ vasoactive dị ka glucagon na VIP.

N'ime ndị ọrịa e gosipụtara maka ịwa ahụ akwara, Sandostatin, nke ejiri ya rụọ ọrụ na mgbe a wasịrị ya ahụ, belatara ọghọm nsogbu ọrịa postoperative (dịka ọmụmaatụ, nnukwu ọrịa pancreatic, pistula fistula, sepsis, abscesses).

Site na ọrịa shuga na-akpata ọrịa na Acquired Immunodeficiency Syndrome (AIDS), Sandostatin zuru oke ma ọ bụ akụkụ nkịtị na-eme ka oche dị ihe dị ka 30% nke ọrịa shuga na-enweghị ike iji ọgwụ mgbochi zuru oke na / ma ọ bụ ọgwụgwọ ọgwụ zuru oke.

Mlọ ọgwụ

Mgbe nchịkwa subcutaneous gasịrị, a na-etinye octreotide ngwa ngwa na kpamkpam. Oke plasma ịta nwere ruru nkeji iri atọ.

Na protein plasma na - ejikọ aka na 65%. Mata ụbụrụ ọbara dị obere. Olu nkesa - 0.27 l / n'arọ. Nchịkọta zuru ezu bụ 160 ml / min.

Mgbe ogwu ogbugba gachara, ọkara ndụ (T_½) - 100 nkeji Drawepụ ọgwụ ahụ mgbe ebidoro nchịkwa mgbochi n'ime ụzọ abụọ, T_½ bụ 10 na 90 min, n'otu n'otu. Nnukwu ọgwụ a na-adịkarị na feces, ihe dịka 32% - na mmamịrị na-agbanweghi.

Ihe ngosi maka ojiji

acromegaly: na-ezughi oke nke radieshọn / ọgwụgwọ ịwa ahụ iji chịkwaa ihe ngosipụta nke ọrịa na obere ọkwa GR (hormone) na IGF-1 (insulin-like development factor) na plasma, ọ bụrụ na onye ọrịa ahụ jụrụ ịrụ ọrụ ahụ ma ọ bụ ọ bụrụ na enwere contraindications maka mmejuputa ya, mkpụmkpụ. ọgwụgwọ n'etiti oge dị iche iche maka ọgwụgwọ radieshon ruo oge ọ ga-etolite mmetụta ya nke ọma.
na-ezochi azụ endocrine nke eriri afọ (eriri afọ) na pancreas (maka njikwa mgbaze): VIPs, glucagonomas, carcinoid na-eme na ọnya carcinoid, insulinomas (maka ọgwụgwọ mmezi na maka ịchịkwa hypoglycemia n'oge mkpado), somatoliberin , nke eji mara hyperproduction nke na-ahapụ ihe na-akpata GR), gastrinomas / Zollinger - Ellison syndrome (nke a na - ejikọ ọnụ na iji ọgwụ mgbochi histamine H.₂ndị na-anabata ya na ndị na-egbochi mgbapụta proton). Ekwesiri iburu n'uche na Sandostatin abụghị ọgwụ mgbochi, na iji ya adịghị eduga n'ịgwọ ụdị ndị ọrịa a,
refractory afọ ọsịsa na ọrịa AIDS (ịchịkwa mgbaàmà),
nsogbu na-esote ịwa ahụ (maka mgbochi),
ọbara ọgbụgba si na ụbụrụ ụkwara ahụ dịgasị iche iche na ọrịa imeju (ya na usoro ọgwụgwọ akọwapụtara (dịka ọmụmaatụ, sclerotherapy endoscopic) iji kwụsị ọbara ọgbụgba ma gbochie nlọghachi).

Ihe ngbanwe

Ihe mgbochi zuru oke na ọgwụgwọ bụ ọnụnọ nke hypersensitivity nke akụkụ nke ọgwụ ahụ.

Dịka ntuziaka ahụ si dị, ekwesịrị iji nlezianya mee ihe Sandostatin:

cholelithiasis
ọrịa shuga mellitus
ime
oge ịfeụ ara.

Ngwongwo na-agwọ ọrịa

Ọnụahịa: site na 1750 ruo 1875 rubles.

Ọgwụ nwere mmetụta antithyroid n'ahụ ahụ, ebe mmepụta nke homonụ dịka TSH na STH na-ebelata, nke na-eso na ngosipụta nke mmetụta antispasmodic akpọpụtara. Sandostatin nwere mmetụta akọwapụtara na ngụgụ nri - ọ na-ebelata motility na mmepụta ihe ọ juiceụ gastụ gastric. N'okpuru mmetụta nke ọgwụ a, a na-achọpụta mgbochi nke serototin na homonụ na-eto (nke a na-arụpụta nke usoro endocrine kpọmkwem) yana peptides.

Ọgwụ na-emetụta njikọ nke uto uto nke insulin hypoglycemia, na-egbochi ihe nzuzo glucogan, gastrin, ụfọdụ peptides, yana insulin. Octreotide na-akwụsị usoro nke mmepụta thyrotropin n'okpuru mmetụta nke thyroliberin. Mgbe nchịkwa nke azịza dị n'okpuru anụ ahụ, a naghị edekọ hyperecretion homonụ.

N'ime ndị mmadụ na-arịa acromegaly, ọgwụ a na-ebelata ọ bụghị naanị ihe ngosi nke homonụ na-eto, kamakwa somatomedin A n'ọbara. Usoro ọgwụgwọ na-eduzi nwere ike ịme ka ọkwa nke hormone nke na-eto eto na 50% nke ndị ọrịa.

N'ime ndị ọrịa nwere akpụ akpịrị, a na-ebelata ịdị njọ nke mgbaàmà njiri mara, ọgwụ na-achịkwa ọkwa nke serotonin, eriri afọ na-ahazi, na “ọkụ ọkụ” na-ewepụ.

Na pathologies akwara mmiri nke vasoactive intestinal peptide, iwere octreiotide na-eme ka ọdịmma kawanye mma, yana itule electrolyte na-alaghachi na nkịtị na ọgwụgwọ. Ọ dị mma ịmara na n'ọtụtụ ọnọdụ, ọrịa ahụ na - akwụsị, olu nke neoplasm na - ebelata, ohere nke ịgbasa metastases na imeju na-ebelata.

Ndị mmadụ na-arịa ọrịa shuga na-arị elu na-achọpụta mbelata dị ukwuu na ya megide usoro ọgwụgwọ octreotide. N'ihi nke a, ọ ga - ekwe omume ịme ka ịha ahụ dị nkịtị, belata ọnụego glucagon n'ime ahụ. A na-atụkarị Sandostatin ka ejiri ya na ihe mgbochi H2 na-egbochi ya, yana ndị na-egbochi proton pump, nke na-enwe mmetụta dị mma na ogo nke mgbaàmà dị iche iche na ọkwa nke gastrin (a na-achọpụta mbelata).

N'okpuru mmetụta nke ọgwụ, mbelata ọnụego insulin na-egbochi immunoreactive na ndị mmadụ chọpụtara insulinoma (a na-ahụ nsonaazụ dị mma n'ime awa 2). Ndị nwere usoro neoplasm na-ahụ maka mmezi normoglycemia mgbe ọwachara ahụ.

Site na imepụta oke hormone na-eme ka ihe na-emepụta ihe belata, a na-achọpụta mbelata ogo ihe ịrịba ama nke acromegaly. A na - enweta mmetụta a site na igbochi mmepụta hormone, yana ihe ntọhapụ ya. Na-esote, olu nke hyhroprophied gland gland na-ebelata.

Na ọgwụgwọ Sandostatin, a na-ewepụ lethargy, isi ọwụwa achọpụtala na mbụ na-apụ n'anya, ihe mgbaàmà hyperhidrosis, ihe mgbu na ọkpụkpụ na nkwonkwo, yana akụkụ neuropathy akụkụ na-apụ n'anya.

Mmetụta akụkụ na ị andụbiga mmanya ókè

N'oge ọgwụgwọ, mmepe nke mgbu afọ, ọgụ nke ọgbụgbọ, afọ ọsịsa, flatulence, mmụba nke ọkwa microsomal enzymes, steatorrhea, alopecia anaghị achịkwa Ọrịa ịba ọcha n'anya, hyperbilirubinemia, mmụba na ntanetị GGT.

Mgbe ọgwụgwọ agbatịsịrị ogologo oge, ịnagide glucose nwere ike ibelata, nsogbu na pancreatitis, hypoglycemia, mmepe nke cholelithiasis, ngosipụta nfụkasị, yana omume nke hyperglycemia na-adịgide adịgide ga-ekwe omume.

Ọ ga - ekwe omume na mmetụta na - enwu ọkụ, ngosipụta nke ihe mgbu mpaghara, na - emegharị na ebe nbanye.

Ahụ erughi afọ
Ntoputa nke "tides"
Ọkpụkpụ ọgbụgbọ
Mbelata olu obi
Abdominal spastic syndrome.

Egosiputara oria Symptomatic.

F-Synthesis, Russia

Ọnụahịa site na 616 ruo 23800 rub.

Octreotide bụ ọgwụ yiri Sandostatin, nke nwere nsonaazụ somatostatin dị n'ahụ ahụ. E gosipụtara ya maka ọgwụgwọ na mgbochi nke ọrịa nje endocrine dị iche iche. A na-emepụta ya n’ụdị usoro ntụtụ.

Uru:

Enwere ike ịkọwa ya maka ọrịa ọrịa pancreatitis nke na - apụta mgbe a wasịrị ya ahụ
Na-egbochi mmepe nke sepsis postoperative
Na -ebilata afọ ọsịsa na -akpata ọrịa AIDS.

Cons:

Hyperbilirubinemia nwere ike ịmalite n'oge ọgwụgwọ
Enweghi ike ijikọ ya na mmanya.
Relelị site na ndenye ọgwụ.

Ozi ọgwụ

Sandostatin bụ anaparastatik nke mmadụ na-ahụ anya. N'ime ahụ mmadụ, a na-emepụta homonụ protein a na ebe abụọ: hypothalamus na agwaetiti endocrine nke pancreas. Ihe a na - arụ ọrụ n’ime ihe ndị nwere ihe ndị dị ndụ nwere ikike inhibitory na mmepụta nke ọtụtụ homonụ otu mgbe: thyrotropin na homonụ na - eto, ma na - ebelata ihe nzuzo nke insulin, cholecystokinin, gastrin, glucagon.

Ihe bụ isi ọgwụ ọgwụ Sandostatin bụ octreotide, a na-egosipụta analogue nke homonụ ahụ site n'omume ogologo karịa nke somatostatin eke.

A na-eme Sandostatin n'ụdị ihe eji agwọ ọnya ma ọ bụ lyophilisate maka nkwadebe ya. Otu ampoule nwere olu nke 1 ml nwere ike ịnwe ọgwụ nke 0.05 mg ma ọ bụ 0.1 mg nke ihe na-arụ ọrụ.

Aha njirimara iji

Dịka ntuziaka maka ọgwụ a si dị, ndị nrụpụta na-achịkwa iji Sandostatin mee ihe n'okwu ndị a:

Acromegaly.
Ọkpụkpụ homonụ nke endocrine nke akwara nke na-efe efe na eriri afọ (Zollinger-Ellison syndrome, ọnya carcinoid na ọnụnọ ọnya carcinoid, VIPoma, insulinoma, wdg).
Ọbara si na varicose veins nke esophagus (dịka akụkụ nke ọgwụgwọ zuru oke).
Mgbochi nke nsogbu na ndị ọrịa a na-etinye aka.

Ntị! Sandostatin enweghị ihe nke ọgwụ antitumor ma enweghị ike iji ya mee ihe dị ka monotherapy maka ọrịa nje oncological ndị a.

Mmekọrịta na ọgwụ ndị ọzọ

Ebe Sandostatin nwere nsonaazụ sistemu n'ahụ ahụ onye ọrịa, ojiji ya nwere ike ịchọ ndozi nke ọgwụ ụfọdụ ndị ọrịa na-anata ugbu a.

N'ihi ike nke homonụ ahụ nwere ike ị emetụta ọnụego obi na olu olu, a na-achọkarị mgbazi nke antiarrhythmics (beta blockers) na ndị na-ahụ maka antihypertensive (ndị mgbochi calcium, diuretics, wdg).

Ojiji nke bromocriptine na Sandostatin na-eduga na nkwalite bioavailability nke ergot alkaloid a. Ma n'ihe banyere ọgwụ ọjọọ emechighị emezi, nsonaazụ ya bụ kpamkpam: njikọta nke Cyclosporin na Sandostatin na-eme ka mbelata cytostatic.

Ọ dịkwa mkpa ka a degharịa ọgwụ nke belata shuga dị n'ọbara, ọ bụrụ na onye ọrịa enweta insulin injectable, mgbe ahụ ọ ga-achọ nweghachi mmezigharị nke ọgwụ ya.

Sandostatin na-eme ka mmebi ahụ dị na mkpolata cimetidine ma belata usoro metabolic nke ọgwụ cytochrome na-anyụ.

Pancreatitis na ọgwụgwọ ya

Ọrịa pancreatitis (mbufụt nke pancreas) na-apụta n'ihi erighị ihe na-edozi ahụ, ị drinkingụ mmanya na ọtụtụ kọfị, iji ọgwụ ụfọdụ, ọrịa nke sistemụ biliary, na ọtụtụ nsogbu ndị ọzọ. Nosology a nwere ụdị ọgwụgwọ abụọ dị iche iche dị iche iche: nnukwu na-adịghị ala ala, ọgwụgwọ nke dị oke iche.

Ihe dị mkpa nke pancreatitis bụ mbibi nke pancreas site na nri enzymes, nke ọ na-amịpụtakwa. Dị ka ọ na-adị, mmepe nke nsogbu ndị dị otu a na-egbochi igbochi ihe ọreatụreatụ nke palọ na-egbu site na mmiri n'ime obere eriri afọ, nke na-eduga na mkpokọta enzymes n'ime lobules na-emepụta ha, ime ihe ngwa ngwa nke nchebe na mbibi nke anụ ahụ.

Sandostatin nwere mmetụta na-akụda mmụọ na ọrụ nzuzo nke pancreas, yabụ, ndị dọkịta na-awa ahụ na-enyekarị ya ndị ọrịa siri ike bụ́ ndị a wara ahụ maka nnukwu ọrịa ọ na-akpata.

Nke a ga - enyere gị aka belata ihe mgbaàmà mgbu, ebe ọ bụ na mbelata mmepụta nke enzymes diges na - agbadata usoro nke mbibi ọzọ nke akwara nke akụkụ ahụ metụtara.

N'ihe banyere nnukwu ọrịa pancreatitis, olu nke mbibi buru oke ibu, ndị ọrịa dị otú a chọrọ ịbanye n'ụlọ ọgwụ ngwa ngwa n'ụlọ ọgwụ na-eme ihe ike, na-echekwa ma na-ejikarị ọgwụgwọ ịwa ahụ. Ọ bụrụ na ọrịa ahụ dị obere, yana oge iwe na mwepu nke mgbaàmà, mgbe ahụ, ọ nwere ike bụrụ na anyị na-ekwu maka ọrịa na-adịghị ala ala. Ọ nwere ike itolite ruo ọtụtụ afọ na iri afọ, ebe ọ bụ na usoro mkpali na-emetụta obere akụkụ nke pancreas. N'otu oge, na ọrịa pancreatitis na-adịghị ala ala, mbibi nke anụ ahụ pancreatic ga-ekwe omume ọbụlagodi na-enwe ọfụma nke ọrịa ahụ.

N'agbanyeghi eziokwu na ekwughi iji Sandostatin maka pancreatitis ala ala na njiri mara maka ojiji, a na-enye ya ndi ọrịa oge ufodu iwe. Approachzọ ọgwụgwọ dị otú ahụ na-eme ka onye ọrịa nwee ahụ iru ala ngwa ngwa, mana ihe fọrọ nke nta ka ọ ghara imetụta ugboro na oge nke iwe ọkụ n'ọdịnihu. Agbanyeghị, ọtụtụ ndị dọkịta na-ahọrọ ịghara iji Sandostatin mee ihe na ọgwụgwọ nke ndị ọrịa na-arịa ọrịa na-adịghị ala ala, ebe ọ bụ na ọ chọrọ nhọrọ nke usoro ọgwụgwọ zuru oke ma nwee ọtụtụ ọgwụ mgbochi na mmetụta ọjọọ.

Ọgwụ

Sandostatin bụ ọgwụ a na-edenye ọgwụ ọ kwesịrị ka a na-enyocha ya nke ọma. Tupu ịmalite usoro ọgwụgwọ ahụ, a na-atụ aro ka ịnwale ọtụtụ ọbara, yana ịchọrọ nyocha nke ultrasound nke oghere afọ na pancreas. N’ọdịnihu, a ga-eme nyocha ndị a ka inyocha mmetụta Sandostatin na ahụ.

A na-achịkwa Sandostatin subcutaneously, intramuscularly ma ọ bụ dị ka ihe na-akpata nsị nke ugboro atọ kwa ụbọchị, a na-ahapụ ya ka ọ jiri mmiri gwọọ ọgwụ. Ekwesịrị ịkọwa okwu mmeghe n'etiti nri, yana tupu oge ịrahụ ụra, si otú a belata ohere nke ịmalite akụkụ nke mmetụta ndị ọzọ.

A na-ahọrọ ọ̀gwụ nke ọgwụ ahụ kpam kpam, dabere na ọrịa ahụ na ogo ya.

Ogologo oge ọgwụgwọ ya na Sandostatin dabere na nosology ma nwee ike ịdị ụbọchị ise ruo ụbọchị asaa ruo ọtụtụ ọnwa. Yabụ iji gbochie nsogbu ndị ọrịa nwere ọrịa ọria akwara na-awa ahụ nke na-awa ahụ, a na-enye Sandostatin opekata mpe otu awa tupu ọrụ ahụ yana n'ime ụbọchị asaa mgbe ọ gbasịrị ya.

Vidio ahụ na-ekwu maka usoro nke Sandostatin:

Ntụziaka pụrụ iche

Ndọghachi azụ adịkarịghị na ọgwụgwọ ndị ọrịa nwere gastroentero-pancreatic endocrine neoplasms.

N'inyocha neoplasms chọpụtara, a chọrọ nlezianya nyocha nke ndị ọrịa maka ịchọpụta uto tumo na warawara nlele.

N'ime ndị ọrịa nwere ọrịa nyocha insulinomas akara ịrị elu na ogo na oge hypoglycemia. Site na ntinye nke Sandostatin na etiti oge n'etiti nri, yana n'oge ụra, enwere ike belata ogo mmetụta dị na ya site na mgbari nri.

Site na ọgwụgwọ acromegaly ruo ogologo oge, inyocha ultrasound nke ọnọdụ ahụ bụ iwu eriri afọ maka oge nyocha nke ọrịa gallstone. A naghị atụ aro ka ịnye nsị obere oge dị mkpirikpi n'otu mpaghara.

Edere Sandostatin mgbe ị na-enye nwa ma na-atụrụ ime dabere n'ihe ngosipụta zuru oke.

Site na nchịkwa obere obere oge, enwere ike izere ịgbanye glucose na glucose. N'oge ọgwụgwọ, a na-achọ nyocha nke shuga ọbara kwa ụbọchị.

Enweghi ike ịhazi Sandostatin LAR intravenously, a na-achịkwa ya nke ukwuu intramuscularly (ọkacha mma gluteus maximus). A banye na ọdụ ọbara, a ga-achọ dochie agịga na mpaghara ịgba ọgwụ.

Kedu ọgwụ ndị na-agwọ ọnya afọ

Otu n'ime ndị ọgwụ ewu ewu ma jiri ogologo oge bụ ọgwụ antacids. Ọgwụ ndị a gụnyere ndị ọrụ nchekwa mmadụ nke na - egbochi oke acid acid. Nke a gụnyere sodium bicarbonate, ma ọ bụ soda. Uru nke ọgwụ a dị na njikọta acid ahụ ozugbo, ọghọm ya dị na mkpasu iwe nke mgbanwe alkaline n’ime ahụ n’ihi mmụba nke soda a na-emeghị eme.

Calcium carbonate bụ ọgwụ siri ike karịa ọgwụ a kọwara n’elu, mana o nwere otu ụdị mmetụta. Ọgwụ iji ogologo oge eme ihe na-akpata afọ ntachi na nke abụọ.

Ọgwụ antacid maka ọnya afọ gụnyere magnesium oxide, magnesium trisilicate, hydroxide aluminom. Ihe ndị a nwere mmetụta na-adọrọ adọrọ ma na-egbochi. A na-ahụ ihe dị na Alkhay na ọgwụ dịka Vicalin, Bellgin, Bekarbon, Vikair, Almagel, Fosfalugel, Maaloks.

Mmetụta antacid bụ belata obi mgbu na mgbu, gosipụtara n'ihi mbelata acidity nke ọdịnaya nke afọ. Mmetụta nke ọgwụ ndị a dabere na ikike ikike ha ma dịgide ruo minit 20 ruo 60. A na-ewere ọgwụ ndị kachasị mma na obere doses ruo 6 ugboro n'ụbọchị tupu nri yana n'abalị. Na-ewepu ihe mgbaàmà nke ọrịa, antacids na-esighi ike na-eme ka ọgwụgwọ nke ọnya adịghị emetụta ihe kpatara ọrịa ahụ.

Ndị na-egbochi ihe nzuzo

Ọgwụ megide ọnya afọ nke otu a nwere ihe cimetidine. Ọ na-egbochi akwara ndị na-eme ka akwara ndị ahụ pụta na agịga homonụ nke na-akpalite nguzobe nke hydrochloric acid. Dabere na cimetidine, Ranitidine, Nizotidine, Famotidine na ọtụtụ analogues na-emepụta.

N'okpuru ike nke ọgwụ ndị a, a na-egbochi ike pepsin na hydrochloric acid, a na-ewepụ ihe mgbu na afọ mgbu. Omume ahụ na-amalite ozugbo ị takingụsịrị ọgwụ ọjọọ ahụ, ihe mgbu ahụ na-apụ n'anya mgbe ụbọchị 5 gasịrị, vomiting na obi mgbawa - mgbe otu izu gasịrị. Ulcers na-amalite ịgwọ ọrịa n’ime izu isii na isii, nke dị oke ọsọ karịa mgbe ị na-eji ọgwụ ndị ọzọ. Mmetụta ọghọm dị obere.

Ndị na-egbochi ọgwụ ịgbanye ọgwụ ọgwụ

Ọgwụ ndị a maka ọnya afọ nwere mmetụta na-enweghị isi. Na mgbakwunye na igbochi nzuzo, ha na-emetụta usoro ndị ọzọ na akụkụ ahụ. Ọgwụ dị iche iche na-enyere aka n'ịgwọ ọnya. Ọgwụ ahịhịa dị n'okirikiri bụ wepụta belladonna, nke nwere mmiri atropine. Ọ bụghị naanị na ihe a na --emepụta mmepụta hydrochloric acid, mana ọ na - ebelata ọrụ moto nke afọ. Mgbapụta Belladonna bụ akụkụ nke nkwadebe ndị dị ka Bellalgin, Bellastesin, Bekarbon.

Ngwakọta platifillin, yana metacin, nke dịpụrụ adịpụ na akwụkwọ snowdrop, enwechaghị arụ ọrụ. Ha na -eme ka ihe mgbu nke afọ ma jiri nwayọ wedata nzuzo ya.

Gastrocepin ma ọ bụ pirenzepine na - enyere aka igbochi nlọghachi na ọgwụgwọ nke ọnya. Ume a dị irè, ruo ogologo oge na-ebelata acid acid, enweghị ihe ọ bụla na-emetụta ọrụ gastric.

Ọgwụ nke acid na-egbochi mkpụrụ ndụ na - egbochi ọnya afọ - Omeprazole. Ọ na-emepụta mmetụta na-adịgide adịgide, a na-eji ya maka ọgwụgwọ mmezi. Ọgwụ homonụ ọhụrụ “Sandostatin”, “Octreotide”, yana “Diakarb” diure na-eso akpata mbelata nke nzuzo.

Ọnya afọ: ọgwụgwọ na ọgwụ ọgwụ cytoprotective

Otu a gụnyere ọgwụ na-echekwa sel nke gastric mucosa. Ha kachasị dị irè maka ọnya afọ, mgbe a na-ebelata ihe nchebe nke mucous akpụkpọ ahụ. Enwere ọtụtụ ọnụọgụ cytoprotectoral. Fọdụ n'ime ha na - enye aka na - amụba ọmụmụ nke imi na - egbochi. Ndị a bụ ọgwụ dabere na mgbọrọgwụ licorice (Flacarbin granules, extracts, licorice syrup, mbadamba Likvirshpon) na calamus rhizomes (nkwadebe Vikalin na Vikair). Ndị ọzọ na-amụba ihe nchebe nke imi. Nke a bụ ihe eji achọ mma site na mgbọrọgwụ nke elecampane (mbadamba Alantoin), ihe ọ juiceụ ofụ nke kabeeji kabeeji.

Site na ọnya miri emi, ọbara ọgbụgba, ọgwụ ọnya afọ ka egosipụtara - ndị na-eme ihe nkiri (ọgwụ “Ulkogant”, “Carafate”, “Keal”).

Nkwadebe Bismuth

Ọgwụ maka ọnya afọ nke dabere na akụkụ a nwere mmetụta jikọtara ọnụ. Ha na-ekpuchi ntụpọ nke mucosa, na-eke ihe mgbochi. Na mgbakwunye, ha na-egbochi ọrụ nke acid na afọ, na-egbu ụmụ ahụhụ na-akpata ọnya (Helicobacter pylori). Ọgwụ kachasị dị irè bụ De-nol.

N'ime usoro ahụike, enwere ọrịa nke chọrọ nnabata nke ụfọdụ arụ ọrụ ahụ: nzuzo nke enzymes, homonụ. Nke a dị mkpa maka ndụ zuru oke ma ọ bụ n'oge ọrụ ịwa ahụ maka mgbake nkịtị na oge ọrụ. Casesdị nsogbu a gụnyere acromegaly, cancer, usoro nke usoro endocrine, enweghị ike usoro ọgwụgwọ oge (ọgwụgwọ radieshon, ntinye ịwa ahụ).

Ntuziaka maka iji Octreotide

Ọgwụ a na-ezo aka analogues sịntetik ma ọ bụ usoro dị iche iche nke homonụ eke nke mmadụ. Ihe na-arụ ọrụ na-anọchi somatostatin, ọ nwere otu ọgwụ ọgwụ, mana ọ na-enwekwu ogologo. Ọgwụ Octreotide na-egbochi imepụta homonụ nke uto, insulin, serotonin, glucagon, gastrin, nke a na-amịpụta oke karia n'ihi ọrịa ma ọ bụ mgbe erichara nri.

Usoro onunu ogwu na nhazi

Ọgwụ bụ ihe dị ike na-egbochi mmepụta homonụ, yabụ, mgbanwe mgbanwe n’usoro iji ọgwụ ma ọ bụ ndenye ọgwụ n’ejighi ndụmọdụ nke dọkịta. Iji ọgwụ ọjọọ eme ihe n'ụzọ na-ezighi ezi na-eduga na mmepe arụmọrụ nke ọrịa na-akpata, ma ọ bụ ịmalite nke ndị ọhụrụ n'ihi ọkwa homonụ ezughi oke. Edebere usoro na usoro ịgba ọgwụ mgbochi naanị na-eburu n'uche nchoputa na ọnọdụ nke otu onye ọrịa. Ana-edobe ụdị depot na Long dị iche intramuscularly.

Nlele maka onwu nlebara anya maka oria di iche iche bu ndi a:

octreotide maka pancreatitis (nnukwu) - 100 mcg ugboro atọ n'ụbọchị maka ụbọchị 5 subcutaneously (s / c) (ọ ga-ekwe omume ịbawanye ọgwụ ahụ ruo 1200 mcg / ụbọchị site na injection n'ime akwara (iv)),
nkwụsị ọnya afọ - 25-50 mcg / hour iv maka ụbọchị 5,
nkwụsị ọbara ọgbụgba (varicose) ọbara nke esophagus - 25-50 mcg / hour iv maka ụbọchị 5,
prophylactic dose n'oge arụ ọrụ - 100-200 mcg s / c 1-2 awa tupu ịwa ahụ, 100-200 s / c ugboro atọ / ụbọchị - mgbe ịwa ahụ ruo ụbọchị 5-7,
acromegaly ma ọ bụ eriri afọ gastroenteropancreotic - 50-100 mcg 1-2 injections kwa ụbọchị.

Mkparịta ụka ọgwụ ọjọọ

Ọgwụ na-agbado oriri nke cimetidine ma belata nnabata nke cyclosporine. Yiri nke diuretics, beta-blockers, insulin, ọgwụ hypoglycemic nke onyunyo, ndị na - egbochi calcium Channel na - egbochi mmezi dose. Usoro ndu nke bromocriptine na-abawanye. A na-enye ọgwụ ọgwụ nke metabolization nke enzymes nke usoro cytochrome P450 n'okpuru nlekọta siri ike nke ọkachamara.

Dodoụbiga ya ókè

N'oge usoro ọgwụgwọ, enwere ike ịchọpụta ịdoụbiga ihe ọ inụ inụ nke egosipụtara ihe mgbaàmà ya: ọgbụgbọ, nchapu ihu, mmetụta nke afọ efu, mbelata obi, ọnya. Ọ bụrụ na otu n'ime ihe ịrịba ama ndị a emee, kwụsị ọgwụgwọ ma kpọtụrụ dọkịta.

Ọnọdụ nchekwa

Chekwaa ọgwụ ahụ na friji na okpomọkụ nke + 2 ... + 8ºC.Ejikwala ọgwụ ahụ. Wepụ ìhè anyanwụ.

Exbọchị mmebi

Ogologo oge nchekwa - afọ 3.

Ngwakọta na ụdị ntọhapụ

Ihe na-arụ ọrụ bụ okreotide. Thedị mgbapụta ahụ bụ ampoules nwere usoro maka nchịkwa subcutaneous na intravenous na microspheres maka imepụta nkwusioru maka nchịkwa intramuscularly.

Ime na lactation

N’ime afọ ime ma na-a breastụ ara, enyeghị ọgwụ a iwu.

Jiri na nwata

Enweghị ihe omuma banyere iji ọgwụ ahụ maka ụmụaka.

Usoro ahịa ọgwụ ahịa

N’ebe a na-ere ọgwụ, ọgwụ rere ya.

N’okpuru afọ ọnya a g’eji ghọta ntọala nke arụ n’ile n’ahụ n’ime mgbidi. Ọzọkwa, usoro na-adịghị mma na-emetụta isi akpụkpọ anụ mucous. Tupu ịhọrọ ọgwụ maka ọnya afọ, ịkwesịrị ịma ntakịrị ihe gbasara ọrịa ahụ.

Ọrịa ọnya dịgasị iche iche

Dika omimi nke ọnya ahụ siri dị, ọnya bụ ihe na-enweghị isi, na-emetụta nanị akpụkpọ ahụ mucous, na nke miri emi, na-ejide oghere ahụ na uru ahụ. Site na mbibi nke mgbidi nke akụkụ ahụ, ha na-ekwu maka mbibi ọ bụla, ma ọ bụ nke gafere. N'okwu a, a na-awụpụ ihe dị n’ime afọ ahụ n’ime oghere dị n’afọ. Site na ọrịa ahụ ruo ogologo oge, ndị agbata obi nwere ike ịrapara n'ahụ mgbidi nke anụ ahụ gosipụtara site na mpụga, mmetụta ọnya ahụ nwere ike gbasaa na ha. N'ọnọdụ yiri nke ahụ, anyị na-ekwu maka ịbanye, ọnya anụ ahụ.

Kedu ọgwụ ndị na-agwọ ọnya afọ

Calcium carbonate bụ ọgwụ siri ike karịa ọgwụ a kọwara n’elu, mana o nwere otu ụdị mmetụta. Ọgwụ iji ogologo oge eme ihe na-akpata afọ ntachi na nke abụọ.

Ndị na-egbochi ihe nzuzo

Ndị na-egbochi ọgwụ ịgbanye ọgwụ ọgwụ

Ngwakọta platifillin, yana metacin, nke dịpụrụ adịpụ na akwụkwọ snowdrop, enwechaghị arụ ọrụ. Ha na -eme ka ihe mgbu nke afọ ma jiri nwayọ wedata nzuzo ya.

Ọnya afọ: ọgwụgwọ na ọgwụ ọgwụ cytoprotective

Site na ọnya miri emi, ọbara ọgbụgba, ọgwụ ọnya afọ ka egosipụtara - ndị na-eme ihe nkiri (ọgwụ “Ulkogant”, “Carafate”, “Keal”).

Nkwadebe Bismuth

Ntuziaka maka iji Octreotide

Ngwakọta na ụdị ntọhapụ

Octreotide dị naanị na ọnụọgụ maka nchịkwa intramuscular na subcutaneous. Olu nke ampoules bụ 1 na 5 ml. Usoro onunu ogwu di iche n’iche banyere ihe n’oru ihe n’ime 1 ml nke osisa: 50, 100, 300, 600 mcg. Liquid ahụ enweghị odo na isi adịghị. A na-enye ọgwụ a n'ọgwụ bọọdụ kpuchiri ekpuchi. Octreotide-Depot na Octreotide-Long bụ ntụ ntụ lyophilized maka infusion (n'ụdị ụfọdụ, agbakọtara ya na mbadamba) zuru oke na njupụta, nkwụghachi ụgwọ, sirinji pụrụ iche na agịga intramuscular.

Nri n’ime nkwadebe

Mmiri maka ịgba ntụtụ

Octreotide-Depot nwere copolymer nke dl-lactic na glycolic acid, polysorbate-80, mmiri maka ntụtụ, D-mannitol, sodium salt nke carboxymethyl cellulose. Maka ọgwụ ọgwụ Octreotide-Long, carmellose sodium, a na-eji D-mannitol. Ihe dị iche n'etiti ụdị atọ nke ọgwụ bụ:

ọsọ ọsọ,
oge ịchọrọ ịta ahụ ọgwụgwọ nke arụ ọrụ n'ime ahụ,
ụzọ nke mmetụta.

Pharmacodynamics na pharmacokinetics

Emeputara ogwu ahu iji kpochapu homonụ nke aru nke ndi oria meputara n’arughi oke site na nri. Nke a metụtara glucagon, insulin, gastrin, serotonin, insulin. Octreotide na-ebelata mmepụta nke hormone na-akpata site na mgbatị anụ ahụ, arginine, ma ọ bụ insulin hypoglycemia. A na-egbochi ọgwụ nzuzo nkerotrotpin.

A na-eji ọgwụ ahụ eme ihe iji belata ihe ize ndụ nke usoro ịwa ahụ mgbe arụchara ịwa ahụ na pancreas (pancreatic fistula, nnukwu pancreatitis mgbe ịwa ahụ, sepsis, abscesses). A na-eji Octreotide eme ihe, yana ọgwụ ndị ọzọ, iji kwụsị ọbara ọgbụgba yana ọfụma ya na ọrịa ụkwara ume dị iche iche nke afọ na ọrịa eriri afọ.

Site na nchịkwa subcutaneous, a na-etinye ọgwụ ahụ ngwa ngwa o kwere mee: a na-erute itinye uche nke kachasị arụ ọrụ mgbe minit 30 gasịrị. Ihe ahụ mejupụtara protein protein plasma dị na 65%. A na-ewepụ ọgwụ ahụ n'ahụ ya mgbe 100 nkeji jiri nchịkwa subcutaneous. Site na injevenia intravenous, ịhapụ octreotide n'ahụ ya na-arụ n'ọkwa abụọ: mgbe nkeji 10 na 90 gachara. Otutu nke ihe a na-apịpụ eriri afọ, akụrụ na-ewepụ 32% site na akụrụ na-agbanweghi.

Ihe ngosi maka iji Octreotide

O bu ogwu a ka eji egbochi oria homonụ ya nke nwere ọtụtụ ọrịa. Ọzọkwa, a na-eji ọgwụ ahụ eme ihe iji gbochie nsogbu ndị metụtara postolowo na akụkụ nke afọ. Ekwenyere ngwá ọrụ ahụ maka iji ya na ụdị ọgwụgwọ dị iche iche (dịka ọmụmaatụ, endoscopic sclerotherapy). Isi ụzọ eji Octreotide:

nnukwu pancreatitis
Kwụsị ọbara ọgbụgba na ọnya afọ nke duodenum na afọ,
mgbochi na nkwụsị nke varicose veins nwere ọrịa imeju,
ọgwụgwọ na mgbochi nke nsogbu na akpa nwa mgbe ịwa ahụ,
acromegaly, na enweghi ike nke agonists dopamine, enweghi ike ịwa ahụ, ọgwụgwọ radieshon,
eriri afọ endocrine nke eriri afọ nke eriri afọ,
glucagonoma
gastrinoma
refractory (dịghịzi) afọ ọsịsa na ọrịa AIDS.

Usoro onunu ogwu na nhazi

Nlele maka onwu nlebara anya maka oria di iche iche bu ndi a:

octreotide maka pancreatitis (nnukwu) - 100 mcg ugboro atọ n'ụbọchị maka ụbọchị 5 subcutaneously (s / c) (ọ ga-ekwe omume ịbawanye ọgwụ ahụ ruo 1200 mcg / ụbọchị site na injection n'ime akwara (iv)),
nkwụsị ọnya afọ - 25-50 mcg / hour iv maka ụbọchị 5,
nkwụsị ọbara ọgbụgba (varicose) ọbara nke esophagus - 25-50 mcg / hour iv maka ụbọchị 5,
prophylactic dose n'oge arụ ọrụ - 100-200 mcg s / c 1-2 awa tupu ịwa ahụ, 100-200 s / c ugboro atọ / ụbọchị - mgbe ịwa ahụ ruo ụbọchị 5-7,
acromegaly ma ọ bụ eriri afọ gastroenteropancreotic - 50-100 mcg 1-2 injections kwa ụbọchị.

Mkparịta ụka ọgwụ ọjọọ

Nsonaazụ

Ofụ ọgwụ ọjọọ ruo ogologo oge na-akpalite nguzobe nke okwute n'ime otite. Na mgbakwunye na mmeghachi omume nfụkasị na alopecia mgbe ị na-eji ọgwụ ahụ, enwere ike ịdaba na nsogbu dị iche iche. Ọdịdị ha na-adabere n'ịdị ogo nke ọrịa ahụ, ọnọdụ onye ọrịa n'ozuzu ya, yana mmekọrịta ya na ọgwụ. Ekwesịrị ilebara nri anya n'ihi mgbanwe nke nzuzo insulin na homonụ ndị ọzọ. Effects nwere ike inwe mmetụta ọjọọ:

anorexia
ọgbụgbọ, ọgbụgbọ, ọgbụgba, ọkụ, afọ ọsịsa, ọnya afọ, ihe mgbu,
mgbochi eriri afọ (nke na - adịghị ahụkebe)
nnukwu ịba ọcha n'anya na-enweghị cholestasis,
arrhythmia,
bradycardia
hyperbilirubinemia,
hyperglycemia
enwere ikike nnabata glucose,
mmepe nke hypoglycemia na-adịgide adịgide,
itching, na-ere ọkụ, nācha ọbara-ọbara ma ọ bụ akwara na nbanye.

Dodoụbiga ya ókè

Oct useụ ọgwụ Octreotide na oke na-akpalite ịbelata ọnụọgụ obi ruo nwa oge, mmetụ nke ọbara ọgbụgba ruo n'isi na ihu. Iche iche, ịdoụbiga ihe oke ókè nwere ike igosipụta onwe ya na imebi ọrụ eriri afọ: ọgbụgbọ, afọ ọsịsa, mmetụta nke afọ efu (agụụ na mberede), mgbu mgbu. A na-agwọ ọnọdụ ahụ n'ụzọ nnọchi anya, ọ chọghị ịkwụsị ọgwụgwọ (ma e wezụga n'ọnọdụ ndị dị oke mkpa).

Analogs nke Octreotide

Edebere ọgwụ ndị na-edochi ọgwụ maka ịnagide onye nnọchi anya ma ọ bụ na enweghi ike Analogs dịkwa na ndenye ọgwụ, yabụ na usoro iji ha maka onwe ha kama Octreotide agaghị ekwe omume. A ga-echetarịrị na mgbanwe ahụ n’usoro ọgwụgwọ bụ nke ọpụrụiche ọkachamara na-enye na-adabere n’ihe ndị mmadụ na-eme onye ọrịa na usoro ọgwụgwọ. Ihe analogues bu nke Octreotide:

Sandostatin - ntụ ntụ ntụ maka imepụta ihe maka irighiri mmiri nke iv na SC, ihe na-arụ ọrụ bụ octreotide, mmetụta dị n'ahụ ahụ bụ otu ihe,
Somatostatin - ọgwụ nke sitere na ihe dị ọcha nke na - egbochi mmepụta nke homonụ nke ibu, onye na - egbochi serotonin, ụfọdụ peptides,
A na-eji Diferelin, analogue maka nchịkwa subcutaneous na-adabere na tryptorelin acetate, na ọgwụgwọ nke infertility nwanyi, IVF iji gbochie otu homonụ na bekee mgbe enweghi ike iji octreotide,
Ọgwụ Sermorelin - a na - enyocha arụmọrụ na ike arụ ọrụ nke homonụ na - eto (na - enyocha ma ọ ga - ekwe omume ụkọ homonụ nke ụmụaka nwatakịrị).

N'ihi nkọwapụta nke mmepụta, ọgwụ a dị oke ọnụ (analogues adịghị iche nke ukwuu na ọnụahịa ma nwee nkọwa nke aka ha). Ọnụ ego dị elu na ụlọ ahịa ọgwụ na Moscow bụ 1300 rubles. Ọnụ ego ahụ dịgasị iche iche dabere na ụdị ọgwụ, ịta ya, mba mepụtara. Na mpaghara, ngwaahịa mgbe ụfọdụ na-efu 15-30% karịa ọnụ n'ihi ntakịrị ike ya. Nkezi ọnụahịa na Moscow na isi obodo: