Mbadamba Augmentin 125: ntuziaka maka ojiji

Mbadamba mkpuchi, 500 mg / 125 mg na 875 mg / 125 mg

Otu mbadamba ihe

bekee arụ ọrụ: amoxicillin (dị ka amoxicillin trihydrate) 500 mg ma ọ bụ 875 mg,

acid clavulanic acid (dika potassium clavulanate) 125 mg,

ndị na-ebu ụzọ: magnesium stearate, sodium sitashi glycolate ụdị A, sịlịkọn dioxide colloidal anhydrous, microcrystalline cellulose,

ihe mejupụtara shei: titanium dioxide (E 171), hypromellose (5 cps), hypromellose (15 cps), macrogol 4000, macrogol 6000, mmanụ silicone (dimethicone 500).

Mpempe 500 mg / 125 mg

Mbadamba ụrọ ndị ahụ bụ oval to white to whitish in agba, nke a kanyere “A C” ma ọ bụghị n’otu akụkụ ma dị mma n’akụkụ nke ọzọ.

Mbadamba 875 mg / 125 mg

Mbadamba nkume ndị ahụ na-acha odo odo na-acha ọcha site na ọcha ruo na-acha ọcha na agba, na-enwe mkpọchi n'otu akụkụ yana “A” C na-akanye na ya.

Ngwongwo ogwu

Fogwe aka

Amoxicillin na clavulanate na-agbaze nke ọma na usoro ihe omimi nke nwere pH nke anụ ahụ, ihe abụọ ahụ na - agbari ngwa ngwa ma zuo oke site na eriri afọ mgbe nchịkwa ọnụ. Mwepu nke amoxicillin na clavulanic acid bu ezigbo ihe mgbe ị na-a theụ ọgwụ ahụ na mmalite nri. Mgbe ị theụsịrị ọgwụ ahụ n’ime ya, bioavailability ya bụ 70%. Ihe profaịlụ nke ọgwụ abụọ dị na ọgwụ ahụ yiri ihe ruru ya ma gbaruo ugwu kachasị elu (Tmax) n'ihe dị ka elekere 1. Ntinye uche nke amoxicillin na clavulanic acid n’ime obara obara bu otu ihe n’eji eme ihe ndi ozo n’oru amoxicillin na clavulanic acid, n’otu n’otu n’otu iche.

Njikọ nke amoxicillin na clavulanic acid na protein ndị na-edozi plasma nwere oke: 25% maka clavulanic acid na 18% maka amoxicillin. Ogo o doro anya na nkesa dị ihe dịka 0.3-0.4 l / n'arọ nke amoxicillin na ihe dịka 0.2 l / kg maka clavulanic acid.

Mgbe nlekọta gọọmentị gasịrị, a na-enweta mmiri ọgwụ nke amoxicillin na clavulanic acid n’akwara na akwara dị iche iche, mmiri mmiri (akpa ume, akụkụ ahụ, ọnya afọ, adipose), ọkpụkpụ na akwara ahụ, ihe na-akpali agụụ mmekọahụ, mmiri na -akasị ahụ na akụkụ ahụ, akpụkpọ ahụ, akwara na-apụ apụ sputum). Amoxicillin na clavulanic acid fọrọ nke nta ka ọ ghara ịbanye na mmiri cerebrospinal.

Amoxicillin, dị ka ọtụtụ penisiliniins, ka a na-asọpụrụ mmiri ara ehi. Achọpụtakwala mpaghara nke clavulanic acid na mmiri ara. Ewezuga ihe mmetuta nke mmetụ uche, amoxicillin na clavulanic acid anaghị emetụta ahụike nke ụmụaka a na-enye nwa ara. Amoxicillin na clavulanic acid na-agafe ihe mgbochi placental.

A machibidoro Amoxicillin na mmamịrị n'ụdị Penicillinic acid na-adịghị arụ ọrụ na nha nke 10-25% nke were were. Clavulanic acid dị n’ime ahụ na-enwe ọrịre kpụ ọkụ n’ọnụ ma wepụta ya n’ime mmamịrị na feces, yana n’ụdị carbon dioxide site n’ikuku ikuku jupụtara.

Amoxicillin bụ nke akụrụ ga - abụ nke akụrụ, ebe akwara clavulanic acid na - eme ka mkpụrụedị akụrụ na nke extrarenal. Mgbe otu nchịkwa ọnụ nke otu mbadamba 250 mg / 125 mg ma ọ bụ 500 mg / 125 mg, ihe dị ka 60-70% nke amoxicillin na 40-65% nke clavulanic acid na-apụ apụ na mmamịrị n'ime awa 6 mbụ.

Nnyocha dịgasị iche iche ekwenyela na urinary excretion bụ 50-85% maka amoxicillin na 27-60% maka clavulanic acid n'ime awa 24. Maka clavulanic acid, a na-ewepu ego kachasị n'ime elekere abụọ mbụ ka nchịkwa gasịrị.

Ojiji probenecid na-eji nwayọ mkpụkọ akwara nke amoxicillin, mana ọ naghị akwụsị iweze akịkịkaliki acid na akụrụ ya.

Mlọ ọgwụ

Augmentin® bụ ọgwụ nje nwere ọgwụ amoxicillin na clavulanic acid, nwere ụdị nje nje dị iche iche, na-eguzogide ọgwụ beta-lactamase.

Amoxicillin Ọgwụ nje na - sịntetik (beta-lactam), usoro dị iche iche, na - arụ ọrụ megide ọtụtụ microorganisms gram-gram na gram-gram.

Bacterzọ nje ahụ na - eme ihe nke amoxicillin bụ igbochi biosynthesis nke peptidoglycans nke mgbidi nje ahụ, nke na - eduga na nyocha na ọnwụ nke sel nje.

Amoxicillin nwere ike ibute mbibi site na beta-lactamase nke nje ndị na-eguzogide ọgwụ na-emepụta, yabụ na ụdị ọrụ nke amoxicillin naanị adịghị etinye microorganisms na-emepụta enzyme ndị a.

Clavulanic acid - Nke a bụ beta-lactamate, nke yiri na kemịkal maka penisilini, nke nwere ike ime ka enzymes beta-lactamase nke microorganisms na-eguzogide ọgwụ penicillins na cephalosporins, si otú a na-egbochi irighiri mmiri nke amoxicillin. A na-emepụta Beta-lactamases site na ọtụtụ nje na-egbu egbu na-adịghị mma na gram-gram-gram. Clavulanic acid na-egbochi ọrụ nke enzymes, na-eweghachi uche nke nje na amoxicillin. Karịsịa, ọ nwere nnukwu ọrụ megide plasmid beta-lactamases, nke ọgwụ nje na-ejikọkarị ya, mana ọ na-adịchaghị mma megide ụdị 1 chromosomal beta-lactamases.

Ọnụnọ nke clavulanic acid dị na Augmentin® na-echebe amoxicillin site na mmebi nke beta-lactamases ma na-agbasa ụdị dị iche iche nke antibacterial na ntinye nke microorganisms na-eguzogide ọgwụ penicillins na cephalosporins ndị ọzọ. Clavulanic acid n'ụdị otu ọgwụ enweghị mmetụta ọgwụ nje dị egwu.

Usoro mmegide nguzogide

Enwere usoro abụọ maka mmepe nke iguzogide Augmentin®:

- inacering site na ọgwụ ndị na-akpata beta-lactamases, nke na-enweghị mmetụta maka nsị clavulanic acid, gụnyere klaasị B, C, D

- mmebi nke protein na-ejide penicillin, nke na-eduga n'ịbelata mmekọrita nke ọgwụ nje n'ihe metụtara microorganism.

Ezughị oke nke nje nje, yana usoro nke mgbapụta ahụ, nwere ike ibute ma ọ bụ mee ka mmepe nke nguzogide, ọkachasị microorganisms gram-na-adịghị mma.

Aha ya bụ Augmentin®nwere mmetụta nje na-akpata microorganisms ndị a:

Airabes ọma Bacillius anthracis,Enterococcus faecalis,Gardnerella vaginalis,Listeria monocytogenes, Nocardia asteroides,Staphylococcus aureus (na-emetụta methicillin), coagulase-sta staloloccci (na-emetụta methicillin), Ike komboliscoccus,Ahụ ike na-efe efe1,Ike pyogenes yana beta hemolytic streptococci, otu Nwa agbọghọ na-amaghị nwoke,

Gram-ọjọọ aerobes: Actinobacillusactinomycetemcomitans,Capnocytophagaspp.,Eikenellacorrodens,Haemophilusinfluenzae,Moraxellacatarrhalis,Neisseriagonorrhoeae,Pasteurellamultocida

microorganisms anaerobic: Bacteroides isi,Fusobacterium nucleatum,Prevotellaspp.

Okike ndi nwere ike iguzogide

Airabes ọma Enterococcusfaecium*

Microorganisms nwere nguzogide sitere n'okike:

gram adịghị mmaikuku:Acinetobacterumu,Citrobacterfreundii,Enterobacterumu,Legionella pneumophila, Morganella morganii, Providenciaumu, Pseudomonasumu, Serratiaumu, Stenotrophomonas maltophilia,

ozo: Chlamydia trachomatis,Chlamydophila pneumoniae, Chlamydophila psittaci, Coxiella burnetti, Mycoplasma pneumoniae.

1 Ewezuga ụdọ Ahụ ike na-efe efepenisilini na-eguzogide

* Uche sitere n'okike na enweghị nnabata

Ihe ngosi maka ojiji

- nnukwu nje sinusitis (na nkwenye chọpụtara)

- nnukwu mbufụt nke etiti ntị (nnukwu otitis media)

- oke iwe nke akwara oruru ala (ya na achoputara akara)

- urinary tract na-efe efe (cystitis, pyelonephritis)

- ofufe ọrịa nke anụ ahụ na anụ ahụ dị nro (ọkachasị, cellulite, ụta anụmanụ, nnukwu ọgịga na phlegmon nke mpaghara maxillofacial)

- ọrịa nke ọkpụkpụ na nkwonkwo (ọkachasị, osteomyelitis)

Ekwesịrị ịbanye n'ụdị nkwado maka ojiji kwesịrị ekwesị nke ndị na-egbochi nje bacteria.

Usoro onunu ogwu na nhazi

Nnukwu mmetụta na Augmentin® nwere ike ịdị iche site na ọnọdụ mpaghara na oge. Tupu ịkọwa ọgwụ ahụ, ọ bụrụ na ọ ga - ekwe omume, ọ dị mkpa iji nyochaa nnabata nke eriri ndị ahụ dabere na data mpaghara wee chọpụta nnabata site na iji nlele na nyocha nke otu onye ọrịa, ọkachasị n'ihe banyere oke ọrịa.

Enwere ike iji Augmentin® gwọọ ọrịa nke microorganisms na-akpata amoxicillin, yana ọrịa agwakọrịtara nke njexicillin na-akpata ma na-akpata mkpụrụ osisi na-akpata beta-lactamase.

Usoro usoro onunu ogwu ka edobere n’otu n’otu dabere n’afọ, ọ̀ha ahụ, ọrụ akụrụ, ndị na-efe efe, yana ogo ọrịa ahụ.

Iji belata ihe nwere ike ibute ọrịa eriri afọ, a na-atụ aro ka Augmentin with rie nri na mbido nri maka mmịcha kacha. Ogologo oge ọgwụgwọ na-adabere na nzaghachi onye ọrịa na ọgwụgwọ ahụ. Pathofọdụ ọrịa (ọkachasị, osteomyelitis) nwere ike ịchọ ogologo oge. Agaghị aga n'ihu ọgwụgwọ karịa ụbọchị 14 na-enweghị nyochagharị ọnọdụ onye ọrịa ahụ. Ọ bụrụ na ọ dị mkpa, enwere ike ibute usoro ọgwụgwọ (nke mbụ, nchịkwa mgbochi ọgwụ nke iji ọgwụ na-esote na nchịkwa ọnụ).

Ndị okenye na ụmụaka karịrị afọ 12 ma ọ bụ na-eru ihe karịrị 40 n'arọ

Ọrịa dị nfe na-agafeghị oke (ogo ọkọlọtọ)

1 mbadamba 500 mg / 125 mg 2-3 ugboro n'ụbọchị ma obu 1 mbadamba 875 mg / 125 mg 2 ugboro n'ụbọchị

Ọrịa siri ike (otitis media, sinusitis, obere akụkụ okuku ume na akụkụ nke ọrịa urinary)

1-2 mbadamba 500 mg / 125 mg ugboro atọ ma obu 1 mbadamba 875 mg / 125 mg 2 ma ọ bụ ugboro 3 kwa ụbọchị

Oru kachasị kwa ụbọchị maka ndị okenye na ụmụaka karịrị afọ 12 bụ ndị na-eji mbadamba ọgwụ nke 500 mg / 125 mg bụ 1500 mg nke amoxicillin / 375 mg nke clavulanic acid. Maka mbadamba nkume nwere ọgwụ 875 mg / 125 mg, ọgwụ kachasị ọnụ kwa ụbọchị bụ 1750 mg nke amoxicillin / 250 mg nke clavulanic acid (mgbe a na-ewere ya 2 ugboro n'ụbọchị) ma ọ bụ 2625 mg nke amoxicillin / 375 mg nke clavulanic acid (mgbe a na-ewere ya ugboro atọ n'ụbọchị).

Undermụaka na-erubeghị afọ 12 ma ọ bụ na-erughị kilogram 40

Emebeghi ụdị ogwu a maka ụmụaka na-erubeghị afọ iri na abụọ ma ọ bụ ụmụaka na-erughị kilogram 40. Edere ụmụaka ndị a Augmentin® dị ka nkwusioru maka nchịkwa ọnụ.

Ndị ọrịa nwere ọrụ mgbazinye nsogbu

Imeghari onwere dabere na oke aro akwadoro nke amoxicillin na uru ikike idozi ya.

Usoro Augmentin usoro onunu ogwu®

Odighi ndozi uzo achoro

1 mbadamba 500 mg / 125 mg 2 ugboro n'ụbọchị

30 ml / min. Ọrịa ịba ọcha n'anya

Imeghari onodu dabere na oke ọgwụ akwadoro nke amoxicillin.

Ndị okenye: 1 mbadamba 500 mg / 125 mg kwa awa 24 Nhọrọ A na-ahazi 1 dose n'oge usoro ịka ahụ na usoro ọzọ na njedebe nke nnọkọ (iji kwụọ ụgwọ mbelata nke mkpokọ mmiri nke amoxicillin na clavulanic acid).

Mbadamba ụrọ nwere oke ọgwụ nke 875 mg / 125 mg kwesịrị iji naanị ndị ọrịa nwere nhichapụ nkọcha> 30 ml / min. Ndị ọrịa nwere ọria imeju

A na- eji nlezianya na-agwọ ọgwụgwọ; a na-enyocha ọrụ imeju.

Belata Augmentin Dose® ọ dịghị mkpa, usoro onunu ogwu ahụ bụ maka ndị okenye. N'ime ndị ọrịa agadi nwere nsogbu gbasara mkpo ya, a ga-emezigharị ya dịka akọwara n’elu maka ndị okenye nwere ọrụ ezughi oke.

Nsonaazụ

Nsonaazụ ndị achọpụtara na nnwale ụlọ ọgwụ na oge ịre ahịa ka egosiri n’okpuru ma edepụtara ha dabere na nhazi ọkwa na akụrụngwa na oge ihe mere.

A na-ekpebi ugboro ole ihe a mere: Ọtụtụ mgbe (≥1/10), ọtụtụ mgbe (≥1 / 100 na.)

Mpempe mwepụta

Ọgwụ nwere ụdị nnabata ndị a:

• Mbadamba Augmentin 250 mg + 125 mg, Augmentin 500 mg + 125 mg na Augmentin 875 + 125 mg.
• Powder 500/100 mg na 1000/200 mg, bu n’obi maka nkwadebe nke ihe eji egbu egbu.
• Ntụ maka nkwụsị Augmentin 400 mg / 57 mg, 200 mg / 28.5 mg, 125 mg / 31.25 mg.
• Ntụ ntụ Augmentin EU 600 mg / 42.9 mg (5 ml) maka nkwusioru.
• Augmentin CP 1000 mg / 62.5 mg nwere mbadamba mbugharị ha

Pharmacodynamics na pharmacokinetics

Dika Wikipedia si kwuo, Amoxicillin bu onye nje nje njedị irè megide ọtụtụ pathogenic na enwere ike pathogenic ụmụ nje na nnọchite anya ọgwụ mkpịsị mkpụrụ ọgwụ semisynthetic.

Idochi anya transpeptidase na imeghari usoro nhazi mureina (akụkụ kachasị mkpa nke mgbidi nke mkpụrụ ndụ nje) n'oge nkewa na uto, ọ na-akpasu iwe nyocha (mbibi) nje.

A na-emebi Amoxicillin -lactamasesya mere ihe ogba-ama ya adighi erute ụmụ njena-arụpụta -lactamases.

Na-eme dị ka asọmpi na ọtụtụ ikpe irreversvers inhibitor, acid clavulanic mara na ikike ibanye n’ime mgbidi mgbidi nje ma bute mmerụ ahụ enzymesnke dị ma ime ụlọ ma na nsọtụ ya.

Clavulanate na-etolite ogige ejiri rụọ ọrụ -lactamasesnke a na - egbochi mbibi amoxicillin.

Mkpụrụ ọgwụ Augmentin dị irè megide:

• Aerobes (+) ikuku: pyogenic streptococcus otu A na B, pneumococci, Staphylococcus aureus na epidermal, (ewezuga ụdị nsogbu methicillin na-eguzogide), staflococcus saprophytic na ndị ọzọ
• Ikuku (-) aerobes: Ogwe osisi Pfeiffer, Ukwara-nta, gardnerella vaginalis , cholera vibrio wdg
• Gram (+) na gram (-) nke anaerobes: bacteroid, fusobacteria, preotellaswdg
• Ihe microorganisms ndị ọzọ: chlamydia, spirochete, treponema paịlị wdg

Mgbe ogwachara Augmentin, ngwa ọrụ ya abụọ na-agbadata ngwa ngwa ma zuo ezu na ngọngọ nri. Ibepu abacha ihe zuru oke ma oburu na ị were ogwu ma obu sirop mgbe iri nri (na nmalite nri).

Abụọ mgbe e jiri ọnụ mee ya, yana iwebata ihe ngwọta nke Augmentin nke anọ, a na-ahụta usoro ọgwụgwọ nke ihe ndị na-arụ ọrụ nke ọgwụ ahụ na akwara niile na mmiri.

Ngwaọrụ abụọ ahụ na-arụ ọrụ ike na-esighi ike protin ọbara nke plasma (ihe ruru 25% jikọrọ protein protein) amoxicillin trihydratena ọ dịghị ihe karịrị 18% acid clavulanic) Achọpụtaghị nchịkọta Augmentin na akụkụ ọ bụla dị n'ime.

Amoxicillin kpughere ya metabolization na ahu ma wepuga ya akụrụsite na ngha nke diges na udi nke carbon dioxide tinyere ikuku ekuru. 10 ka 25% nke ọgwụ nataraamoxicillin wepụwa akụrụ n'ụdị penisilloic acidnke bu adighi ike metabolite.

Clavulanate site na akụrụ ya na site na usoro ndị ọzọ.

Ihe ngbanwe

Augmentin n'ụdị usoro onunu ogwu ka contraindicated:

• ndị ọrịa nwere ọgwụ mgbochi otu ma ọ bụ akụkụ abụọ nke ọgwụ ahụ, nye onye ọ bụla n'ime ya, yana -lactam (i.e. to ọgwụ nje site na otu penisilini na cephalosporin),
• ndị ọrịa nwetagogola usoro ọgwụgwọ Augmentin jaundice ma ọ bụ akụkọ banyere arụ ọrụ imeju n'ihi ojiji nke ngwakọta nke ihe ndị na-arụ ọrụ nke ọgwụ ahụ.

Mgbakwunye mgbochi ọzọ na nhọpụta ụrọ maka nkwadebe nke nkwusioru ọnụ yana iji ọgwụ nke ihe arụ ọrụ 125 + 31.25 mg bụ PKU (phenylketonuria).

A na-egbochi ntụ ntụ iji kwadebe nkwusioru nke ọnụ na-eji ya eme ihe (200 + 28.5) na (400 + 57) mg:

• na PKU,
• ndị ọrịa nwere nsogbu akụrụna nke egosiReberg nwale n'okpuru 30 ml kwa nkeji
• ụmụaka na-erubeghị afọ atọ.

Mgbakwunye ọzọ maka iji mbadamba nkume nwere ọgwụ ihe eji eme ihe (250 + 125) na (500 + 125) mg bụ afọ n'okpuru afọ iri na abụọ na / ma ọ bụ ibu na-erughị kilogram 40.

Mbadamba ọgwụ nwere ọgwụ ike 875 + 125 mg na-egbochi ọgwụ:

• mebie ọrụ arụmọrụ akụrụ (ndị na-egosi Reberg nwale n'okpuru 30 ml kwa nkeji)
• ụmụaka na-erubeghị afọ iri na abụọ
• ndị ọrịa nke ịdị arọ ya anaghị agafe 40 n'arọ.

Ntụziaka maka iji Augmentin: usoro nke ngwa, usoro onunu ogwu maka ndị ọrịa okenye na ụmụaka

Otu n'ime ajụjụ ndị ọrịa na-ajụkarị bụ ajụjụ banyere etu esi ewere ọgwụ tupu ma ọ bụ mgbe nri gasịrị. N'ihe banyere Augmentin, ị theụ ọgwụ ahụ na iri nri. Echere na ọ kacha mma ị optụ ọgwụ ahụ. tupu nri.

Nke mbu, o na - enye nnabata ha nma nma Ọkpụkpụ afọ, na nke abuo, o nwere ike belata oke ihe obula eriri afọ dyspeptikọ bụrụ na nke ikpeazụ bụ ikpe.

Etu ị ga-esi gbakọọ ọgwụ Augmentin

Etu ị ga-esi ewere ọgwụ Augmentin maka ndị okenye na ụmụaka, yana usoro ọgwụgwọ ya, dabere na nke microorganism bụru ẹphe, ẹphe ele ẹnya iya ọgwụ nje, ogo na njiri mara ọrịa ahụ, nsonye nke ọrịa na-efe efe, afọ na ịdị arọ nke onye ọrịa, yana otu ahụ ọ dị akụrụ onye ọrịa.

Oge ọ na-anọ n’ọgwụ na-adabere n’otú ahụ onye ọrịa si emeghachi omume na ọgwụgwọ.

Mbadamba Augmentin: ntuziaka maka ojiji

Dabere na ọdịnaya nke ihe ndị na-arụ ọrụ n'ime ha, a na-atụ aro mbadamba Augmentin maka ndị ọrịa toro etozi dịka atụmatụ na-esote:

• Augmentin 375 mg (250 mg + 125 mg) - otu ugboro atọ n'ụbọchị. N'ime usoro ogwu a, a na-egosi ọgwụ ahụ maka na-efe efenke ahụ na-abata mfe ma obu udi aru ike. N'ihe banyere ọrịa siri ike, gụnyere ọrịa na-adịghị ala ala na oge nlọghachi, a na-enye usoro ọgwụgwọ dị elu.
• Mbadamba mbadamba 625 (500 mg + 125 mg) - otu ugboro atọ n'ụbọchị.
• Mbadamba 1000 mg (875 mg + 125 mg) - otu ugboro abụọ n'ụbọchị.

Ogwu a dabere na ndị ọrịa nwere arụmọrụ arụmọrụ. akụrụ.

A na-anabata Augmentin CP 1000 mg / 62.5 mg mbadamba mbugharị ndị ọrịa maka ndị ọrịa karịrị afọ 16. Ihe kachasị mma bụ mbadamba abụọ ugboro abụọ n'ụbọchị.

Ọ bụrụ na onye ọrịa enweghị ike ilo mbadamba ihe niile, o kewara abụọ na ụzọ adịghị mma. A na-ewere halves abụọ n'otu oge.

Ndi nwere oria akụrụ Ọ bụ ọgwụ ka etinyere naanị ọgwụ ikpe ebe egosi Reberg nwale karịrị 30 ml kwa nkeji (ya bụ, mgbe achọrọghị mmezi usoro usoro usoro onunu ogwu).

Ntụ ntụ maka iji gwọọ ntụtụ: ntuziaka maka ojiji

Dabere na ntuziaka ahụ, a na-agbanye mgbakwunye n'ime akwara: site na jet (a ga-emejupụta ọgwụ niile na nkeji 3-4) ma ọ bụ site na usoro nfe (oge infusion - site na ọkara otu awa ruo nkeji 40). Ebumnuche a abụghị ka etinye ya n’akwara.

Ọkwa ọkọlọtọ maka onye ọrịa okenye bụ 1000 mg / 200 mg. Ọ na-atụ aro ịbanye na ya awa asatọ ọ bụla, yana maka ndị nwere nsogbu na-efe efe - isii n’ime awa isii ma ọ bụ anọ ọ bụla (dịka ihe gosiri).

Ọgwụ nje n'ụdị ihe ngwọta, enyere 500 mg / 100 mg ma ọ bụ 1000 mg / 200 mg maka mgbochi nke mmepe bu oria mgbe ogwachara ya. N'ọnọdụ ebe oge ịwa ahụ na-erughị otu awa, o zuru ezu ịbanye onye ọrịa otu oge tupu ahu izizi dose nke Augmentin 1000 mg / 200 mg.

Ọ bụrụ na echere na arụmọrụ ahụ ga-ewe ihe karịrị otu elekere, ruo ihe onunu anọ nke 1000 mg / 200 mg ka a na-enye onye ọrịa ahụ n’ụbọchị gara aga maka awa 24.

Nkwụsị Augmentin: ntuziaka maka ojiji

Ntụziaka maka iji Augmentin maka ụmụaka na-atụ aro ịhapụ nkwụsị nke ọgwụ mgmg mg / mg mg 25,25 na mmeri nke 2,5 ruo 20 ml. Otutu nnabata - 3 n’ehihie. Olu nke otu uzo dabere n’afọ na ogo nwata.

Ọ bụrụ na nwatakịrị ahụ etoola ọnwa abụọ, etinyere ọgwụ mgbochi nke 200 mg / 28.5 mg n'ọtụtụ nhata 25 / 3.6 mg na 45 / 6.4 mg kwa 1 n'arọ nke ahụ. Ekwesịrị ịkewapụta usoro ahụ ka ọ bụrụ ntụtụ abụọ.

Egosiputara ya na iji usoro onodu ogwu 400 mg / 57 mg (Augmentin 2) gosiputara maka ojiji malite n’afọ. Dabere na afọ nwata na ịdị arọ nwatakịrị ahụ, otu ụzọ dịgasị si 5 na 10 ml. Otutu nnabata - 2 n'ehihie.

E nyere Augmentin EU iwu site na ọnwa atọ. Ogo kachasị mma bụ 90 / 6.4 mg kwa 1 n'arọ nke ịdị ahụ kwa ụbọchị (a ga-ekewa dose ahụ ka ọ bụrụ usoro 2, na-edebe oge awa 12 n'etiti ha).

Taa, ọgwụ n'ụdị usoro dịgasị iche iche bụ otu n'ime ndị akachasị idebere maka ọgwụgwọ. ọnya afọ.

Augmụaka Augmentin nwere akpịrị mgbu Edebere ya na usoro nke kpebisiri ike dabere nha ahụ na afọ nwata ahụ. Na angina n'ime ndị okenye, a na-atụ aro iji Augmentin na 875 + 125 mg ugboro atọ n'ụbọchị.

Ọzọkwa, ha na-ejikarị nhọpụta nke Augmentin sinusitis. A na-agbakwunye ọgwụgwọ a site na iji nnu nnu n'oké osimiri na-ehicha imi na iji spalys nke nasal Rinofluimucil. Usoro kachasị mma maka sinusitis: 875/125 mg 2 ugboro n'ụbọchị. Oge ihe ọmụmụ ahụ na-abụkarị 7 ụbọchị.

Dodoụbiga ya ókè

Ceedgafe ogo nke Augmentin na-eso:

• mmepe nke imebi site na ngwe nri,
• imebi nguzo nke nnu-mmiri,
• kristalia,
• gbasara akwara,
• ọdịda (ọdịda) nke amoxicillin na urinary catheter.

Mgbe mgbaàmà ndị dị otú ahụ pụtara, a na-egosi onye ọrịa n'ọrịa nkwarụ, gụnyere, n'etiti ihe ndị ọzọ, mgbazi nke nguzozi-nnu mmiri. Dradọrọ Augmentin si kanhazi usoro na-emekwa ka usoro a dịrị ịba ọcha n'anya.

Mmekorita

• na-enyere aka belata tubular secretion nke amoxicillin,
• na-akpalite mmụba nke ịta amoxicillin n'ime ọbara plasma (mmetụta ahụ dịruru ogologo oge),
• anaghị emetụta Njirimara na ọkwa nke ọdịnaya plasma nke clavulanic acid.

Njikọ amoxicillin ya na allopurinol na-abawanye ohere nke mmepe na-apụta allergies. Data Mmekọrịta allopurinol N'otu oge ahụ akụkụ abụọ nke na-arụ ọrụ nke Augmentan anaghị anọ.

Augmentin nwere mmetụta dị n’ime ya microflora eriri afọ nke eriri afọnke ahụ na-akpalite mbelata nke reabsorption (iweghachi azụ) estrogen, yana mbelata na arụmọrụ jikọtara ọnụ ogwu mgbochi diri onu.

Ọgwụ a ekwekọghị n'ihe ngwaahịa ọbara na mmiri nwere protein, gụnyere gụnyere whey protein hydrolysates na abụba emulsion chọrọ itinye n’ime akwara.

Ọ bụrụ na edepụtara Augmentin n'otu oge ọgwụ nje klaasị aminoglycosides, agwaghị ọgwụ ndị ahụ n'otu sirinji ma ọ bụ arịa ọ bụla ọzọ tupu nchịkwa, ebe ọ bụ na nke a na-eduga n'ịgba ume aminoglycosides.

Analogs nke Augmentin

Analogs Augmentin bụ ọgwụA-Klav-Farmeks, Amoxiclav, Amoxil-KBetaclava Clavamitin, Medoclave, Teraclav.

Nke ọ bụla n'ime ọgwụ ndị dị n'elu bụ ihe Augmentin nwere ike dochie ya na enweghị ya.

Ọnụahịa analogues dị iche iche site na 63.65 ruo 333.97 UAH.

Augmentin maka ụmụaka

A na-eji Augmentin eme ihe n'ọtụtụ ụmụaka. N'ihi eziokwu ahụ bụ na o nwere ụdị ntọhapụ ụmụaka - sirop, enwere ike iji ya na-emeso ụmụaka ruo otu afọ. N'ụzọ dị mkpa na-eme ka oriri nnabata na eziokwu na ọgwụ nwere ụtọ uto.

Maka umuaka ọgwụ njena-akọwakarị maka akpịrị mgbu. A na-ekpebi usoro onyonye nke ụmụaka ahụ site afọ na ibu. A na-eke oke elele dị ka onyonyo abụọ, nke hà 45 mg / n'arọ kwa ụbọchị, ma ọ bụ ekewa atọ, usoro nke 40 mg / kg kwa ụbọchị.

Etu ị ga-esi theụọ ọgwụ ahụ maka ụmụaka yana ugboro ole usoro onunu ogwu dabere na usoro usoro onunu ogwu enyere.

Maka umuaka nke aru ha kariri 40 n'arọ, ka edeputara Augmentin otu ogwu ahu dika ndi oria okenye.

A na-eji Augmentin sirop maka ụmụaka ruo otu afọ na dosages nke 125 mg / 31.25 mg na 200 mg / 28.5 mg. Ekwuputara ọgwụ ọnụọgụ 400 mg / 57 mg maka ụmụaka karịrị otu afọ.

Aremụaka nọ n’agbata afọ isii na isii ruo iri isii (ihe dị ka kilogram 19) na-ahapụ ka ha depụta ma nkwusioru yana Augmentin na mbadamba. Usoro onunu ogwu nke udiri ogwu a di otu a:

• otu mbadamba 250 mg + 125 mg ugboro atọ n'ụbọchị,
• otu mbadamba 500 + 125 mg ugboro abụọ n'ụbọchị (ụdị usoro a bụ ezigbo).

Edebere ụmụaka gafere afọ 12 ka ha were otu mbadamba ụrọ nke 875 mg + 125 mg ugboro abụọ n'ụbọchị.

Iji tụọ dose nke ngwụcha Augmentin nke ọma maka ụmụaka na-erubeghị ọnwa 3, a na-atụ aro iji ụdị sirinji dee sirinji. Iji mee ka nkwusioru nke ụmụaka na-erubeghị afọ abụọ gbadata, a na-ahapụ ya ka ọ jiri mmiri wee ghee syrup ahụ na ogo 50/50

Ihe atụ nke Augmentin, nke bụ ọgwụ ya, bụ ọgwụ Amoxiclav, Flemoklav Solutab, Arlet, Rapiclav, Ecoclave.

Mmanya ndakọrịta

Augmentin na mmanya abụghị ndị na-emegide ya n'okpuru ị ofụ mmanya na-aba n'anya ọgwụ njeanaghị agbanwe Njirimara ọgwụ ya.

Ọ bụrụ n’ịzụlite usoro ọgwụgwọ ọgwụ ọjọọ, ọ dị mkpa ị drinkụ mmanya, ọ dị mkpa ịlele ọnọdụ abụọ: imeru ihe n’ókè na ịdị nfe.

Maka ndị na-arịa ị alcoholụbiga mmanya ókè, ị simụ ọgwụ ahụ n'otu oge iji mmanya nwere ike ịnwe nsonaazụ ka njọ.

Abuse abuseụbiga mmanya ókè n'ụzọ na-akpata ọgba aghara dị iche iche na-arụ ọrụ imeju. Ndi nwere oria imeju Ntụziaka ahụ na-atụ aro ka ejiri ọgwụ akpachara anya dezie Augmentin, ebe ọ bụ na eburu amụma etu akụkụ ahụ na-arịa ọrịa ga-esi akpa agwa ndị chọrọ ịnagide ya.xenobioticsiri ezigbo ike.

Ya mere, iji zere ihe ize ndụ na-ezighi ezi, a na-atụ aro ka ịhapụ ị alcoholụ mmanya n'oge oge ịgwọ ya na ọgwụ ahụ.

Augmentin n'oge afọ ime na lactation

Dị ka ọtụtụ ọgwụ nje penisilini otu, amoxicillin, nke ekesara n’arụ ahụ, na-abanyekwa n’ime mmiri ara. Ọzọkwa, ị ga-achọta ịta mmiri na mmiri ara ehi. acid clavulanic.

Agbanyeghị, ọ nweghị mmetụta dị njọ na ahụike ekwenyeghị na ọnọdụ nwatakịrị ahụ. N'ụfọdụ, nchikota acid clavulanic ya na amoxicillin nwere ike kpasuo nwa afọ ọsịsa na / ma ọ bụ candidiasis (thrush) nke akpụkpọ ahụ mucous n'ime oghere olu.

Augmentin so n ’ụdị ọgwụ eji eme nwa ara. Ọ bụrụ, n'agbanyeghị nke a, site na usoro ọgwụgwọ nne ji Augmentin, nwatakịrị ahụ nwere mmetụta uto na-adịghị mma, a na-akwụsị inye nwa ara.

Nnyocha ụmụ anụmanụ egosila na ihe ndị na-arụ ọrụ nke Augmentin nwere ike ịbanye mgbochi hematoplacental (GPB). Agbanyeghị, ọ nweghị mmetụta dị njọ na mmepe nwa ebu n’afọ ka amatapụtara.

Ọzọkwa, teratogenic mmetụta adịghị na ma parenteral ma nchịkwa nke ọgwụ.

Ojiji nke Augmentin n'ime ụmụ nwanyị dị ime nwere ike iduga mmepe nke nwa amụrụ ọhụrụ necrotizing enterocolitis (NEC).

Dịka ọgwụ ndị ọzọ niile, a naghị akwado Augmentin maka ụmụ nwanyị dị ime. N'oge ọmụmụ nwa, a ga-anabata ya naanị n'ọnọdụ ebe, dịka nyocha dọkịta si dị, uru dịịrị nwanyị gafere karịa ihe egwu nwatakịrị ya nwere.

Nyocha banyere Augmentin

Nyocha nke mbadamba na nkwụsị nke ụmụ Augmentin maka akụkụ kachasị nke oma. Ọtụtụ na-enyocha ọgwụ ahụ dị ka ọgwụgwọ dị irè na nke a pụrụ ịtụkwasị obi.

N'ọmụmụ ihe ebe ndị mmadụ na-ekwupụta mmetụta ha banyere ọgwụ ụfọdụ, nkezi ọgwụ akara bụ 4.3-4.5 n'ime 5 isi.

Nyochaa banyere Augmentin nke nne nke ụmụ na-eto eto na-egosi na ngwaọrụ ahụ na-enyere aka ngwa ngwa ịnagide ọrịa ndị dị ka nwata dị ka ọla kọpa ma obu akpịrị mgbu. Na mgbakwunye na ịdị mma nke ọgwụ, ndị nne na-ahụkwa ụtọ uto ya, nke ụmụaka nwere mmasị.

Ngwá ọrụ dịkwa irè n'oge afọ ime. N'agbanyeghị eziokwu ahụ na nkuzi ahụ anaghị atụ aro ka a na-emeso ụmụ nwanyị dị ime (karịchaa na 1st ọkara), a na-edekarị Augmentin na ọkara nke abụọ na nke atọ.

Dabere na ndị dọkịta, isi ihe mgbe ị na-eji ngwá ọrụ a bụ ịlele usoro onunu ogwu ma soro ndụmọdụ niile nke dọkịta gị.

Ọnụahịa Augmentin

Ọnụahịa Augmentin na Ukraine dịgasị iche dabere na ụlọ ahịa ọgwụ akọwapụtara. N'otu oge ahụ, ọnụ ahịa ọgwụ dị ntakịrị na ụlọ ahịa ọgwụ na Kiev, a na-ere mbadamba nkume na sirop na pharmacies na Donetsk, Odessa ma ọ bụ Kharkov na ọnụ ala dị ala.

A na-ere mbadamba 625 mg (500 mg / 125 mg) na ụlọ ahịa ọgwụ, na nkezi, na 83-85 UAH. Ọnụ ọnụ nke Augmentin mbadamba 875 mg / 125 mg - 125-135 UAH.

Can nwere ike ịzụta ọgwụ mgbochi n'ụdị ntụ ntụ maka nkwadebe nke ihe ngwọta maka injection ya na iji ọgwụ nke 500 mg / 100 mg nke ihe ndị na-arụ ọrụ, na nkezi, maka 218-225 UAH, ọnụ ahịa Augmentin 1000 mg / 200 mg - 330-354 UAH.

Ọnụahịa nkwụsị nke Augmentin maka ụmụaka:
400 mg / 57 mg (Augustmentin 2) - 65 UAH,
200 mg / 28.5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

Usoro nke ime ihe

Amoxicillin bụ ọgwụ mgbochi ọgwụ nke na-eme ka mmiri dị nro dị n'ọtụtụ ọgụ na -emegide ọtụtụ gram-positive na gram-microorganisms. N'otu oge ahụ, amoxicillin nwere ike ibute mbibi site na beta-lactamases, yabụ kwa ụdị ọrụ nke amoxicillin anaghị erute microorganisms nke na-emepụta enzyme a.

Clavulanic acid, ihe dị na beta-lactamase inhibitor n'ihe metụtara penisilini, nwere ike ịhapụ ịgbatị ọtụtụ beta-lactamases ndị a hụrụ na penisilini na cephalosporin na-eguzogide ọgwụ. Clavulanic acid nwere arụmọrụ zuru ezu megide beta-lactamases nke plasmid, nke na-ekpebikarị iguzogide nje bacteria, ọ dịghịkwa arụ ọrụ megide ụdị chromosomal beta-lactamases 1, nke ọgwụ clavulanic na-egbochi.

Ọnụnọ nke clavulanic acid dị na nkwadebe Augmentin na-echebe amoxicillin site na mbibi site na enzymes - beta-lactamases, nke na-enye ohere ịbawanye ụzarị ọgwụ nje nke amoxicillin.

Nkesa

Dika ihe ndi n’emekorita ogwu nke amoxicillin na clavulanic acid, a na acho acho ihe omimi nke amoxicillin na clavulanic acid n’ahu di iche iche na arua di iche iche (n’ime otite, akpo nke nkpuru ime, akpukpo aru, adipose na akwara akwara, synovial and peritoneal fluid, fluid, and purulent fluid). .

Amoxicillin na clavulanic acid nwere ogo na-esighi ike nke na-ejikọ protein protein. Nnyocha e mere egosiwo na ihe dị ka 25% nke ngụkọta nke clavulanic acid na 18% nke amoxicillin na plasma ọbara na-emetụta protein protein plasma.

N'ime ọmụmụ anụmanụ, enweghị nchịkọta nke ngwa nkwadebe Augmentin® na akụkụ ọ bụla achọtara. Amoxicillin, dị ka ọtụtụ penisiliniins, na-abanye n'ime mmiri ara. A nwekwara ike ịchọta akụkụ nke clavulanic acid na mmiri ara. Ewezuga ohere nke ọgụgụ isi, afọ ọsịsa, ma ọ bụ candidiasis nke akpụkpọ ahụ mucous, enweghị mmetụta ndị ọzọ nke amoxicillin na clavulanic acid na ahụike nke ụmụ a na-enye nwa ara.

Ọmụmụ banyere ọmụmụ ụmụ anụmanụ egosila na amoxicillin na clavulanic acid na-agafe ihe mgbochi placental. Agbanyeghị, ọ nweghị mmetụta dị njọ na nwa ebu n’afọ achọpụtara.

Metabolism

10-25% nke ọgwụ mbu nke amoxicillin bụ nke akụrụ na-eme ka ọ bụrụ metabolite na-adịghị arụ ọrụ (penisilloic acid). Clavulanic acid bụ metabolized nke ukwuu ruo 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1 H-pyrrole-3-carboxylic acid na 1-amino-4-hydroxybutan-2-otu ma kpụrụ ya na akụrụ site na ngọngọ diges, yana ikuku kubie ume n'ụdị carbon dioxide.

Dị ka ọgwụ penicillins ndị ọzọ, amoxicillin na-apụkarị site na akụrụ, ebe a na-ahụ ọgwụ clavulanic acid site na usoro gbasara akụrụ na extrarenal.

Ihe dị ka 60-70% nke amoxicillin na ihe dị ka 40-65% nke clavulanic acid bụ nke akụrụ na-agbanweghi agbanwe n’ime awa 6 mbụ ka nchịkwa ọgwụ ahụ gasịrị. Usoro nlekọta nke probenecid na-eme ka ahụmịlị nke amoxicillin pụọ, mana ọ bụghị clavulanic acid.

Usoro onunu ogwu na nhazi

Maka nchịkwa ọnụ.

A na-edobe usoro usoro onunu ogwu n'otu oge dabere na afọ, oke ahụ, ọrụ akụrụ nke onye ọrịa, yana ogo ọrịa ahụ. Iji belata nsị nke eriri afọ nwere ike iwepụta ma mee ka mmịpụ nke ọma, a ga-a drugụ ọgwụ ahụ na mbido nri. Obere oge nke ọgwụ mgbochi bụ ụbọchị 5.

Ọgwụ ekwesịghị ịga n’ihu karịa ụbọchị iri na anọ na-enweghị nyocha banyere ọnọdụ ụlọ ọgwụ.

Ọ bụrụ na ọ dị mkpa, a ga - enwe ike ịme ọgwụgwọ na - nzọụkwụ (nke mbụ, nchịkwa intravening nke nkwadebe Augmentin a n'ụdị usoro onunu ogwu; ntụ ntụ maka nkwadebe nke ihe ngwọta maka nchịkwa intravenous na ntinye nke ọzọ na nkwadebe Augmentin in n'ụdị usoro ọgwụgwọ).

Ekwesịrị icheta na mbadamba 2 nke Augmentin® 250 mg + 125 mg abụghị otu mbadamba Augmentin® 500 mg + 125 mg.

Ọrịa ịba ọcha n'anya

Imeghari usoro onunu ogwu dabere na oke ọgwụ a tụrụ aro ya. 1 mbadamba mbadamba 500 + 125 mg n’otu ọgwụ n’ime awa iri abụọ na anọ ọ bụla

N’oge usoro omumu ihe omimi, ihe onwa ozo (otu mbadamba) na mbadamba ihe ozo na ngwucha okwu a (iji kwụọ ụgwọ mbelata nke ihe ogugu nke amoxicillin na clavulanic acid).

Ime

N'ime omumu banyere oru omumu na anumanu, onu na ochichi nke Augmentin® emeghi teratogenic. N'ime otu nnyocha ụmụ nwanyị nwere membranes akatabeghị aka, achọpụtara na ọgwụ ọgwụ prophylactic nwere ike ịnwe n'ihe egwu dịkwuo elu nke necrotizing enterocolitis n'ime ụmụ amụrụ ọhụrụ. Dị ka ọgwụ niile, a naghị atụ aro Augmentin® maka oge a dị ime, belụsọ na uru nne elere anya nne ga-akacha n'ihe nwa ebu n’afọ.

Oge ara

Enwere ike iji ọgwụ Augmentin® mee ihe n’oge a na-enye nwa ara. Ewezuga ohere nke nghọta, afọ ọsịsa, ma ọ bụ candidiasis nke akpụkpọ ahụ mucous n'ụdị metụtara nnabata ọnya ọgwụ nke ọgwụ a n’ime mmiri ara, ọ nweghị mmetụta ọjọọ ndị ọzọ ka amụtara n’ime ụmụ ara ara. N'ọnọdụ nke mmetụta ọjọọ n'ime ụmụ a na-enye nwa ara, a ga-akwụsị ịhapụ inye ụmụaka ara.

Ntụziaka pụrụ iche

Tupu ịmalite ojiji nke Augmentin, achọrọ akụkọ banyere ahụike nke onye ọrịa ka amata mmeghachi omume hypersensitivity nwere ike ịhapụ penicillin, cephalosporin na akụkụ ndị ọzọ.

Mkpesa Augmentin nwere ike imebi ezé onye ọrịa. Iji zere mmepe nke mmetụta dị otú ahụ, ọ zuru ezu iji debe iwu nke usoro ịdị ọcha nke ọnụ - ịzọpụ ezé gị, na-eji nsị.

Nnabata Augmentin nwere ike ibute ọgbụgba, yabụ maka oge ọgwụgwọ ahụ kwesịrị ịhapụ ịkwọ ụgbọala na ịrụ ọrụ chọrọ nlebara anya ka ukwuu.

Agaghị enwe ike iji Augmentin ma ọ bụrụ na enyo ụdị mononucleosis na-efe efe.

Augmentin nwere ezigbo ntachi obi na obere nsí. Ọ bụrụ na ọgwụ a chọrọ ogologo oge, ọ dị mkpa ịlele oge ọrụ nke akụrụ na imeju.

Nhazi ọkwa nosological (ICD-10)

1 N'ime mmepụta ọgwụ, a na-edobe ọgwụ clavulanate potassium na ngafe 5%.

A na-ewepụ mmiri dị ọcha n'oge mkpuchi ihe nkiri.

Nkọwa nke ụdị usoro onunu ogwu

Ntụ ntụ: ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha, nwere njirimara na-esi isi. Mgbe diluted, etisasị na-acha ọcha ma ọ bụ ihe fọrọ nke nta ọcha. Mgbe ị kwụ ọtọ, ihe na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke ọma na-eji nwayọọ nwayọọ.

Mbadamba ụrọ, 250 mg + 125 mg: kpuchie ya na ihe nkiri site na ọcha ruo ihe fọrọ nke nta ka ọ bụrụ ọcha, oval ke udi, ya na ihe odide a bu "AUGMENTIN" n'otu akụkụ. N'oge kink: site na ọcha na-acha odo odo ruo ihe fọrọ nke nta ka ọ bụrụ ọcha.

Mbadamba ụrọ, 500 mg + 125 mg: kpuchie ya n'ọbọ ihe nkiri site na ọcha rue ihe fọrọ nke nta ka ọ bụrụ ọcha na agba, oval, nke e dere ihe akpọrọ "AC" yana ihe egwu dị n'otu akụkụ.

Mbadamba ụrọ, 875 mg + 125 mg: kpuchie ya n'ọbọ ihe nkiri site na ọcha rue ihe fọrọ nke nta ka ọ bụrụ ọcha, na oval n'ụdị ya, ya na mkpụrụedemede "A" na "C" n'akụkụ ya na ahịrị mmebi dị n'otu akụkụ. N'oge kink: site na ọcha na-acha odo odo ruo ihe fọrọ nke nta ka ọ bụrụ ọcha.

Mlọ ọgwụ

Ngwakọta ọrụ niile dị na nkwadebe Augmentin - - amoxicillin na clavulanic acid - na - ewebata ngwa ngwa site na eriri afọ mgbe nchịkwa ọnụ gasịrị. Ntinye nke ihe aru oru n’ime ogwu Augmentin ® di ezigbo nma ma oburu ị takingụ ogwu n’oge mbido nri.

E gosipụtara usoro ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid na ọmụmụ dị iche iche n'okpuru, mgbe ndị ọrụ afọ ofufo ahụike dị afọ 2-12 na afọ efu weere 40 mg + 10 mg / kg / ụbọchị nke ọgwụ Augmentin ®, ntụ ntụ maka nkwụsị ọnụ, na usoro atọ. Mg mg + 31,25 na 5 ml (156.25 mg).

Ihe puru iche gbasara ogwu

Amoxicillin

Augmentin ®, mg mg + 31.25 mg na 5 ml

Clavulanic acid

Augmentin ®, mg mg + 31.25 mg na 5 ml

A na-egosi usoro ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid dị na ọmụmụ dị iche iche n'okpuru, mgbe ndị ọrụ afọ ofufo ahụike dị afọ 2-12 afọ na afọ efu weere Augmentin ®, ntụ ntụ maka nkwụsị ọnụ, 200 mg + 28.5 mg na 5 ml (228 , 5 mg) na nha nke 45 mg + 6.4 mg / kg / ụbọchị, kewara abụọ.

Ihe puru iche gbasara ogwu

E gosipụtara usoro ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid na ọmụmụ dị iche iche n'okpuru, mgbe ndị ọrụ afọ ofufo nwere ahụike weere otu ọgwụ Augmentin ®, ntụ ntụ maka nkwusi ọnụ, 400 mg + 57 mg na 5 ml (457 mg).

Ihe puru iche gbasara ogwu

Thelọ ọgwụ ọgwụ pharmacookinetic nke amoxicillin na clavulanic acid, enwetara n'ọmụmụ ihe dị iche iche, mgbe ndị ọrụ afọ ofufo na-ebu ọnụ na-arịa ọrịa were:

- 1 taabụ. Augmentin ®, 250 mg + 125 mg (375 mg),

- 2 mbadamba Augmentin ®, 250 mg + 125 mg (375 mg),

- 1 taabụ. Augmentin ®, 500 mg + 125 mg (625 mg),

- 500 mg nke amoxicillin,

- 125 mg nke clavulanic acid.

Ihe puru iche gbasara ogwu

Amoxicillin na nchịkọta nke ọgwụ Augmentin ®

Clavulanic acid n'ime ihe mejupụtara ọgwụ Augmentin drug

Mgbe ị na-a Augụ ọgwụ Augmentin pla, ihe ndị na-enye nsogbu na plasma nke amoxicillin yiri nke ndị na-ahụ maka nchịkwa ọnụ nke amoxicillin hà.

Thelọ ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid, enwetara n'ọmụmụ akwụkwọ dị iche iche, mgbe ndị ọrụ afọ ofufo na-ebu ọnụ na-arịa ọrịa were:

- 2 mbadamba Augmentin ®, 875 mg + 125 mg (1000 mg).

Ihe puru iche gbasara ogwu

Amoxicillin na nchịkọta nke ọgwụ Augmentin ®

Augmentin ®, 875 mg + 125 mg

Clavulanic acid n'ime ihe mejupụtara ọgwụ Augmentin drug

Augmentin ®, 875 mg + 125 mg

Dịka ọ dị na nchịkwa iv nke ngwakọta nke amoxicillin na clavulanic acid, a na-ahụta ọgwụgwọ amoxicillin na clavulanic acid n'ọtụtụ anụ ahụ na ọnya ọnya dị iche iche (eriri afọ, ọnya afọ, anụ ahụ, abụba na akwara anụ ahụ, ọnya synovial na peritoneal fluid, fluid, fluid) )

Amoxicillin na clavulanic acid nwere ogo na-esighi ike nke na-ejikọ protein protein. Nnyocha e mere egosiwo na ihe dị ka 25% nke ngụkọta nke clavulanic acid na 18% nke amoxicillin na plasma ọbara na-emetụta protein protein plasma.

N'ime ọmụmụ anụmanụ, enweghị nchịkọta akụkụ nke nkwadebe Augmentin in na anụ ahụ ọ bụla achọtara.

Amoxicillin, dị ka ọtụtụ penisiliniins, na-abanye n'ime mmiri ara. A nwekwara ike ịchọta akụkụ nke clavulanic acid na mmiri ara. Ewezuga enwere ike ịmalite ọrịa afọ ọsịsa na candidiasis nke akpụkpọ ahụ mucous, ọnweghị mmetụta ndị ọzọ nke amoxicillin na clavulanic acid na ahụike nke ụmụ a na-enye nwa ara.

Ọmụmụ banyere ọmụmụ ụmụ anụmanụ egosila na amoxicillin na clavulanic acid na-agafe ihe mgbochi placental. Agbanyeghị, ọ nweghị mmetụta dị njọ na nwa ebu n’afọ achọpụtara.

10-25% nke ọgwụ mbu nke amoxicillin bụ nke akụrụ na - eme ka metabolite na - adịghị arụ ọrụ (penisilloic acid). Clavulanic acid bụ metabolized nke ukwuu ruo 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-3H-pyrrole-3-carboxylic acid na amino-4-hydroxy-butan-2-otu ma wepụta ya site na akụrụ Ọkụ afọ, yana ikuku kubie ume n'ụdị carbon dioxide.

Dị ka ọgwụ penicillins ndị ọzọ, amoxicillin na-apụkarị site na akụrụ, ebe a na-ahụ ọgwụ clavulanic acid site na usoro gbasara akụrụ na extrarenal.

Ihe dị ka 60-70% nke amoxicillin na ihe dị ka 40-65% nke clavulanic acid bụ nke akụrụ na-agbanweghị na aka elekere isii mbụ ka emesịrị 1 tebụl. 250 mg + 125 mg ma ọ bụ mbadamba 1 500 mg + 125 mg.

Oge nlekọta probenecid na-eme ka a kwụsịlata amoxicillin, mana ọbụghị clavulanic acid (lee "Mmekọrịta").

Na-egosi Augmentin ®

E gosipụtara nchikota nke amoxicillin na clavulanic acid maka ọgwụgwọ nke nje na-efe efe nke ọnọdụ ndị na-esonụ nke microorganisms nwere mmetụta na nchikota nke amoxicillin na clavulanic acid:

ọrịa elu akụkụ akụkụ iku ume (gụnyere ọrịa ENT), dịka ọmụmaatụ tonsillitis, sinusitis, otitis media, na-ebutekarị Ahụ ike oyi na-akpata prọdia, Hemophilus influenza 1, Moraxella catarrhalis 1 na plogenes nke Symptococcus, (ewezuga mbadamba Augmentin 250 mg / 125 mg),

Ọrịa dị ala nke akụkụ okuku ume na akwara, dị ka nkụda mmụọ nke ụkwara ume ọkụ, ụkwara ume ọkụ, na ọnya na-efe efe, bụ́ nke na-akpatakarị. Ahụ ike oyi na-efe efe nke Hemophilus 1 na Moraxella catarrhalis 1,

ọrịa ọnya na-efe efe, dị ka cystitis, urethritis, pyelonephritis, ọrịa nke akụkụ nke akụkụ nke nwanyị, nke na-akpatakarị ụdị ezinụlọ. Enterobacteriaceae 1 (nke ka nke Escherichia coli 1 ), Staphylococcus saprophyticus na umu Enterococcusyana gonorrhea kpatara Neisseria gonorrhoeae 1,

Akpịrị anụ ahụ na anụ ahụ dị nro na-ebutekarị Staphylococcus aureus 1, pyogenes Streptococcus na umu Bacteroides 1,

Ọkpụkpụ nke ọkpụkpụ na nkwonkwo, dịka osteomyelitis, na-ebutekarị Staphylococcus aureus 1, ọ bụrụ na ọ dị mkpa, ọ ga-ekwe omume ịgwọ ọrịa ogologo oge.

ọrịa odontogenic, dịka ọmụmaatụ periodontitis, odontogenic maxillary sinusitis, ọnụnọ ezé siri ike na mgbasa cellulite (naanị maka mkpụrụ osisi Augmentin, ọnụọgụ 500 mg / 125 mg, 875 mg / 125 mg),

ọrịa ndị ọzọ jikọtara ọnụ (dịka ọmụmaatụ, afọ ime septic, postpartum sepsis, serais intraabdominal) dị ka akụkụ nke usoro ọgwụgwọ (naanị maka mbadamba Augmentin onunu ogwu 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),

1 Ndị nnọchite anya nke ụdị microorganisms akọwapụtara na-emepụta beta-lactamase, nke na-eme ka ha bụrụ ndị na-enweghị mmetụta na amoxicillin (lee. Pharmacodynamics).

Ọrịa Augmentin be nwere ike ịgwọ ọrịa ndị microorganisms na-emetụta amoxicillin, ebe ọ bụ na amoxicillin bụ otu n'ime ihe ndị dị na ya. Augmentin ® ka egosiri maka ọgwụgwọ nke ọrịa nje jikọtara nke microorganisms nke nwere amoxicillin, yana microorganisms na-emepụta beta-lactamase, na-emetụta nchikota nke amoxicillin na clavulanic acid.

Nzuzo nke nje na nchikota nke amoxicillin na clavulanic acid dịgasị dabere na mpaghara na oge. N'ebe enwere ike, ekwesiri iburu n'uche ọgụgụ data mpaghara. Ọ bụrụ na ọ dị mkpa, a ga-anakọta ma nyocha microbiological maka ịchọpụta ihe banyere nje.

Ime na lactation

Na nyocha nke omumu omumu na anumanu, onu na ochichi nke Augmentin cause emeghi teratogenic.

N'ime otu nnyocha ụmụ nwanyị nwere membranes akatabeghị aka, achọpụtara na ọgwụ mgbochi Augmentin be nwere ike ibute oke ihe egwu nke ọrịa enterocolitis n'ime ụmụ amụrụ ọhụrụ. Dịka ọgwụ niile, a naghị atụ aro ọgwụ Augmentin iji mee n'oge afọ ime, belụsọ na uru nne elere anya nne ga-akacha n'ihe nwa ebu n’afọ.

Enwere ike iji ọgwụ Augmentin ® mee ihe n’oge a na-enye nwa ara. Ewezuga nke enwere ike ịmalite afọ ọsịsa ma ọ bụ candidiasis nke akpụkpọ ahụ mucous nke oghere a na-ejikọta ya na ntinye ọnya ọnya nke ọgwụ a n'ime mmiri ara, ọ nweghị mmetụta ọjọọ ndị ọzọ hụrụ na ụmụ a na-enye ụmụ ara. N'ọnọdụ mmetụta ọjọọ na ụmụaka ndị na-enye nwa ara, ọ dị mkpa ịkwụsị ị breastụ ara.

Emeputa

SmithKlein Beach P.C. BN14 8QH, West Sussex, Vorsin, Clarendon Road, UK.

Aha na adresị nke ụlọ ọrụ iwu nke aha ya nyere akwụkwọ ikike idebanye aha ya: GlaxoSmithKline Trading CJSC. 119180, Moscow, Yakimanskaya nab., 2.

Maka ama ndị ọzọ, kpọtụrụ: GlaxoSmithKline Trading CJSC. 121614, Moscow, St. Krylatskaya, 17, bldg. 3, ala 5. Ogige Azụmaahịa "Ugwu Krylatsky."

Ekwentị: (495) 777-89-00, faksị: (495) 777-89-04.

Irationbọchị mmechi nke Augmentin

mbadamba ihe mkpuchi fim 250 mg + 125 mg 250 mg + 125 - afọ 2.

mbadamba ihe mkpuchi 500 mg + 125 mg - afọ 3.

mbadamba ihe mkpuchi fim 875 mg + 125 mg - 3 afọ.

ntụ ntụ maka nkwusioru maka nchịkwa ọnụ 125mg + 31.25mg / 5ml - afọ 2. Nkwado a kwadebere bụ ụbọchị asaa.

ntụ ntụ maka nkwusioru maka nchịkwa ọnụ 200 mg + 28.5 mg / 5 ml 200 mg + 28.5 mg / 5 - afọ 2. Nkwado a kwadebere bụ ụbọchị asaa.

ntụ ntụ maka nkwusioru maka nchịkwa ọnụ 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - afọ 2. Nkwado a kwadebere bụ ụbọchị asaa.

Ejila oge emechara ka egosiputara na ngwugwu ahụ.