Ọgwụ Clindamycin: ntuziaka maka ojiji

A na-emepụta ọgwụ ahụ n'ụdị nke capsules gelatin nwere anụ ahụ na-acha odo odo na okpu uhie. Capsules nwere ntụ ntụ na-acha ọcha ma ọ bụ nke odo. Capsule ọ bụla nwere 150 mg nke akụrụngwa ike nke clindamycin n'ụdị hydrochloride.

A na-eji Talc, lactose monohydrate, magnesium stearate na ọka ọka mee ihe ndị ọzọ.

Ngwongwo ogwu

Clindamycin nwere ọtụtụ mmetụta na ọ bụ nje nke na-egbochi usoro mmepụta protein na microorganisms pathogenic. Akụkụ bụ isi na-arụ ọrụ megide cocci gram-na microaerophilic, yana anaerobic gram-positive bacilli, nke anaghị etolite etisa.

Imirikiti ụdị clostridia na-eguzogide ọgwụ a. N'akụkụ a, ọ bụrụ na onye ọrịa ahụ nwere ọrịa butere ụdị ụdị a, a na-atụ aro ka eburu ọgwụ nje ahụ ụzọ.

Mgbe ojiji, ọgwụ ahụ na-etinye obi gị dum na eriri afọ. Iri nri na - ebelata oke mmado, mana o nweghi ihe gbasara ogwugwo ogwu n’obara. Ogwu ahu nwere ikike adighi nma site na ihe banyere obara obara, kama o na-abanye aru na udu mmiri dika akpa ume, ntu, otuu, pleura, panti, akwara, akwara na akwara, sputum, synovial fluid, bile ducts, gland prostate, ihe odide ntụkwasị. Na ọnụnọ nke usoro mkpali na meninges, ikike nke ọgwụ nje site na mgbochi ụbụrụ ọbara na-abawanye.

A na-ahụta ọgwụ kachasị elu n'ọbara otu elekere iji ọgwụ capsules. Isi akụrụngwa nke ọgwụ ahụ sitere na ahụ ruo ụbọchị anọ yana enyemaka nke akụrụ na eriri afọ.

Ihe ngosi maka ojiji

Edere ọgwụ ahụ maka ọrịa ndị a:

• Mgbochi ọnya afọ na peritonitis mgbe perforation ma ọ bụ mmerụ ahụ,
• Septicemia
• Ọrịa na-efe efe nke anụ ahụ dị nro na anụ ahụ (panaritium, ọnya, ọnya na-efe efe, ihe ọkụ), yana ọnụ na ọnya afọ (ọnụnọ na peritonitis),
• Ọrịa na-efe efe nke elu akụkụ iku ume yana akụkụ ENT (sinusitis, pharyngitis, otitis media and tonsillitis), sistemụ okuku ume (pleural empyema, aspiration pneumonia, bronchitis and abscess in the lung), diphtheria, fever uhie,
• Endocarditis nke ọdịdị nje,
• Osteomyelitis na-adịghị ala ala ma ọ bụ nnukwu ọrịa,
• Ọrịa na - efe efe nke akụkụ ahụ nke sistemụ urogenital (usoro mbufụt tubo-ovaria, endometritis, chlamydia, ọrịa na-efe efe),
• Ọrịa ndị na-efe efe yana usoro mkpali yana microorganisms pathogenic kpatara na-emetụta ọgwụ mgbochi clindamycin.

Usoro usoro onunu ogwu

Capsules bụ maka nchịkwa ọnụ. Edere ya oge ole ị ga-ewere 150 mg na obere oge nke 6 ma ọ bụ 8 awa. Ọ bụrụ na onye ọrịa na-arịa ọrịa siri ike, enwere ike ịba ụba usoro ya ka ọ bụrụ 300 mg ma ọ bụ 450 mg. Mgbe ị na-edenye ụmụaka ọgwụ otu ọnwa, ọgwụ ha gbadoro 8 ma ọ bụ 25 mg kwa kilogram nke ahụ ha. Mgbe ụbọchị kwesịrị 3 ma ọ bụ 4 doses.

Dodoụbiga ya ókè

Mgbe ị na-a theụ ọgwụ ahụ na usoro onunu ogwu akari oke ọgwụgwọ, mmeghachi omume ojoo nwere ike ịka njọ.

Ọ bụrụ na ịdoụbiga ihe ọseụdoụ ókè, a na-akwado ọgwụgwọ iji belata ihe mgbaàmà ahụ. Okwesiri iburu n’uche na ọgwụ a enweghị ọgwụ mgbochi, yana usoro ọgwụgwọ na hemodialysis enweghị ike dị mkpa.

Mkparịta ụka ọgwụ ọjọọ

Nlekọta ọghara nke Gentamicin, streptomycin, aminoglycosides na rifampicin jikọrọ ọnụ na-abawanye arụmọrụ nke ọgwụ dị n’elu na clindamycin.

Ọnụ na izu ike nke akwara ike, izuike akwara, nke ihe anticholinergics na-akpata, nwere ike ịba ụba.

Enweghị ike ị takenụ ọgwụ ọgwụ Clindamycin nwere ọgwụ dịka magnesium sulfate, aminophylline, ampicillin, calcium gluconate na barbiturates.

Egosiputa Antagonism na chloramphenicol na erythromycin.

Ọ bụghị ihe amamihe dị na ya iji ọgwụ ahụ na ọgwụ ndị dị ka phenytoin, vitamin B ogige, aminoglycosides.

Site na ojiji nke ọgwụ antidiarrheal n'ụzọ ọzọ, ohere nke piseudo-membranous colitis na-abawanye.

Iji ọgwụ narcotic eme ihe (opioid) nwere ike ime ka ịda mbà iku ume (ọbụladị tupu apnea).

Nsonaazụ

Ojiji nke ogwu nwere ike iduga n’inweta mmeghachi omume ọjọọ ndị a:

• Usoro obi: obi ilu, mmetụta adịghị ike,
• Akụkụ Hematopoietic: thrombocytopenia, neutropenia, leukopenia, agranulocytosis,
• Usoro nri: dysbiosis, ọrụ imeju na-arịa ya, esophagitis, pseudomembranous enterocolitis, ịba ụba bilirubin, jaundice, nsogbu dyspeptik,
• Ihe ngosi Allergic: eosinophilia, urticaria, ngosipụta anaphylactoid, dermatitis, pruritus, rash,
• Usoro akwara: mgbanwe nke neuromuscular conduction
• Ndị ọzọ: superinfection.

Ihe ngbanwe

Ekwenyeghị ọgwụ a n'ọnọdụ ndị a:

• Nnukwu uche dị n'akụkụ akụkụ ọgwụ ọ bụla,
• Lactation
• Ọnụnọ nke ọrịa ọrịa na - adịghị ahụkebe,
• Asthma bụ ihe ọla kọpa,
• Afọ dị obere karịa afọ atọ (ịdị arọ nwatakịrị ekwesịghị ịbụ ihe na-erughị 25 n'arọ),
• Oge ime
• Stitches n'ihu ọnya afọ
• Myasthenia gravis

Ekwesịrị ịkpachara anya mgbe ị na-edepụta ọgwụ ahụ maka ndị ọrịa agadi, yana ọnụnọ gbasara akụrụ na akwara.

Ntụziaka pụrụ iche

Ọrịa pseudomembranous colitis nwere ike ịpụta ma n'oge ọgwụgwọ yana mgbe ọ kwụsịrị ọgwụgwọ. A na-egosipụta nsonaazụ n'akụkụ n'ụdị afọ ọsịsa, leukocytosis, ahụ ọkụ na mgbu n'ime afọ (na obere oge, feces nwere imi na ọbara).

N'ọnọdụ dị otú a, o zuru ezu iji kagbu ọgwụ ahụ ma depụta resins ọgwụ ion n ’ụdị colestipol na colestyramine. N'ọnọdụ siri ike nke ọrịa a, ọ dị mkpa iji kwụọ ụgwọ maka ọnwụ nke mmiri, protein na electrolytes na ịhọpụta metronidazole na vancomycin.

N'oge ọgwụgwọ, a na - enye ya ọgwụ iji chekwaa motility eriri afọ.

Emebebeghị nchekwa nke iji ọgwụ ọgwụ Clindamycin na ọrịa ụmụaka, yabụ, na usoro ọgwụgwọ ogologo oge na ụmụaka, a ga-enyocha ọkwa nke ọbara na ọnọdụ ọrụ nke imeju.

Mgbe ị na-a theụ ọgwụ ahụ na usoro ị highụ ọgwụ dị elu, ịkwesịrị ijikwa ego nke clindamycin dị n'ọbara.

Ndị ọrịa na-arịa oke imeju kwesịrị inyocha ọrụ ọrụ umeji.

Mwepụta wepụtara ya na ihe mejupụtara

Clindamycin dị n'ụdị ndị a:

• Ude na-acha ọbara ọbara 2% - site na ọcha nwere ude ma ọ bụ nke na-acha odo odo na-acha ọcha, na-esighi ike isi (20 g na 40 g na tub nke alum, 1 tube nke ọ bụla nwere onye na-etinye ya),
• Gelatin capsules - ya na okpu uhie na nke odo, nke no No. 1, ihe di n’ime okpu-agha bu ucha site na odo odo di ocha rue odo na agba (pcs. N’ime blisters, blisters 2 na kaadiboodu, pcs isii 6. Na blisters, 2 n’ime nke ọ bụla, 5 na 10 blisters na kaadiboodu),
• Ngwọta maka ntụtụ (irighiri intramuscular na intramuscular) - transperent, ucha edo edo ma ọ bụ enweghị agba (2 ml na ampoules, 5 ampoules na blisters, ngwugwu 2 na igbe kaadi).

Ihe mejupụtara 100 g nke ude ude gụnyere:

• Ihe na-arụ ọrụ: clindamycin (n'ụdị phosphate) - 2 g,
• Ngwa inyeaka: sodium benzoate, macrogol-1500 (polyethylene oxide-1500), castor oil, emulsifier Nke 1, propylene glycol.

Ngwakọta nke capsule 1 gụnyere:

• Ihe na-arụ ọrụ: clindamycin (n'ụdị hydrochloride) - 0.15 g,
• Ihe inyeaka: ọka ọka, talc, lactose monohydrate, magnesium stearate,
• Ngwakọta nke mkpuchi mkpuchi capsule: etere na-acha oji ọla edo (E151), titanium dioxide (E171), azorubine dai (E122), quinoline acha odo odo (E104), ponce dye Ponceau 4R (E124), gelatin,
• Ihe mejuputara ahu ahu akpukpo ahu: nwa di ocha dika (E151), azorubine di (E122), gelatin.

Ngwakọta nke 1 ml nke ihe ngwọta maka ntụtụ gụnyere:

• Ihe na-arụ ọrụ: clindamycin (n'ụdị phosphate) - 0.15 g,
• Ihe inyeaka: edetate disodium, mmanya benzyl, mmiri maka injection.

Usoro onunu ogwu na nhazi

Maka ọrịa nke oke na-eto eto maka ndị okenye na ụmụaka ndị gbara afọ 15 (na-eru kilogram 50 ma ọ bụ karịa), a na-enye Clindamycin otu capsule (150 mg) ugboro anọ kwa ụbọchị na oge oge niile. N'ime ọrịa dị egwu, enwere ike ịbawanye otu ugboro site na ugboro 2-3.

Ndi umuaka kariri inye iwu:

• Afọ 8-12 (ibu - 25-40 n'arọ): ọrịa siri ike - 4 ugboro n'ụbọchị, capsule 1, kachasị na ụbọchị - 600 mg,
• Afọ 12-15 (ịdị arọ - 40-50 n'arọ): ogo nke ọrịa ahụ bụ ugboro atọ n'ụbọchị maka capsule 1, ogo nke ọrịa ahụ bụ ugboro atọ kwa ụbọchị maka capsules 2, kacha nke ụbọchị bụ 900 mg.

Ọgwụ okenye a tụrụ aro maka nchịkwa intramuscular na intravenous bụ 300 mg ugboro abụọ kwa ụbọchị. N'ime ọgwụgwọ nke ọrịa siri ike, a na-atụ aro 1.2-2.7 g kwa ụbọchị, kewara n'ime 3-4. Achọghị nchịkwa intramuscular nke otu ọgwụ karịrị 600 mg. Otu kachasị maka nchịkwa mgbochi bụ 1.2 g maka elekere 1.

Maka umuaka site na afo ato, a na-enye Clindamycin iwu na 15-25 mg / kg kwa ụbọchị, kewara n'ime ọchịchị atọ hà nhata. N'ime ọgwụgwọ nke ọrịa dị egwu, enwere ike ịbawanye ọgwụ kwa ụbọchị ruo 25-40 mg / kg site na iji ya ugboro ugboro.

N'ime ndị ọrịa nwere nnukwu akụrụ na / ma ọ bụ ọrịa imeju, n'ihe banyere iji ọgwụ a ka ọ dịkarịa ala elekere asatọ, anaghị achọ mgbazi nke usoro onunu ogwu.

Maka nchịkwa intraven, clindamycin kwesịrị ịbụ nke a ga-agwakọta na mkpokọta na-adịghị elu karịa 6 mg / ml. A na-agbanye azịza ya ghaara ya n'ime nkeji 10-60.

Ka akwadoro irighiri irighiri ihe.

Dịka ihe mgbaze, ịnwere ike iji ngwọta: 0.9% sodium chloride na 5% dextrose. A na-atụ aro ka ịgba mmiri na oge infusion dị ka atụmatụ (dose / olu nke ihe mgbaze / oge infusion):

• 300 mg / 50 ml / 10 nkeji
• 600 mg / 100 ml / 20 nkeji
• 900 mg / 150 ml / 30 nkeji
• 1200 mg / 200 ml / 45 nkeji.

A na-etinye ude ude ka a na-etinye intravaginally. Single dose - otu zuru ude ngwa (5 g), ọkacha mma tupu alakpu ụra. Oge eji ya bụ ụbọchị 3-7 kwa ụbọchị.