Holetar: ntuziaka maka ojiji, analogues, ọnụahịa, nyocha

Ọba ụba nke lipids n’ahụ nwere ike kpalite ịdị njọ na ịrụ ọrụ nke sistem ọbara, obi, akụrụ na umeji. Enwere otutu ntuziaka na ndi mmadu na ogwu iji luso cholesterol di elu. Otu ọgwụ dị otú ahụ bụ Holetar. Taa, anyị ga-atụle arụmọrụ nke Holetard, ntuziaka maka ojiji na uru maka ego.

Ihe ngosi maka ojiji

Edere mbadamba ihe ndị ọzọ dị ka ntuziaka ndị a si dị:

• IIa na hybcholesterolemia nke IIb nke hypercholesterolemia nwere mmụba nke lipids na klas LDL (njupụta dị ala bụ ụdị cholesterol nke na-emetụta ahụ mmadụ na nke nwere ike ibute akwara na atherosclerosis). N'ọnọdụ a, a na-enye Holetar ike arụ ọrụ, ma ọ bụ na-ezughi nsonaazụ usoro ọgwụgwọ nri.
• Ebuli elu triglycerides na hypercholesterolemia agwakọta
• Ndozi nguzozi na ndi oria nwere oria mellitus n’agaghari uzo abuo a
• Site na hyperlipoproteinemia, nke mmega ahụ na-adịghị edozi ahụ na nri kwesịrị ekwesị.
• Maka ọgwụgwọ nke atherosclerosis

Ngwakọta na usoro onunu ogwu

Ndị otu ọgwụ ọgwụ Holetar bụ statins. Ọ na-emetụta ọgwụ ndị na-eme ka anwụ dị nfe, ya bụ na ndị na - egbochi HMG-Coenzyme reductase. Ihe na-arụ ọrụ nke Holetar bụ lovastatin. Ofdị ntọhapụ ya dị n'ụdị mbadamba nkume, ibe 20 kwa ngwugwu. Mbadamba ụrọ nke ọ bụla nwere 20 mg nke ihe bụ isi ọrụ (lovastatin), yana ihe ndị ọzọ - butyl hydroxyanisole, siteri pregelatinized, lactose monohydrate, magnesium stearate, agba agba E131 na microcrystalline cellulose.

Ihe ngbanwe

Ntụziaka nke ọgwụ ahụ na-ekwu na n'ọtụtụ ọnọdụ, Holetar na-egbochi ọgwụgwọ nke ọrịa cholesterol.

Ghara ịhapụ nhọpụta ya n'okwu ndị a:

• Nnukwu eriri afọ na ọrịa imeju - mmụba nke enzymes imeju (transaminases) na - enweghị ihe kpatara ya, ọrịa imeju, ọrịa ndị ọzọ nke imeju na usoro nri.
• Ahụhụ anya. Holetar nwere ike inwe nsogbu n'akụkụ ma na-emebi ọrịa ahụ dịnụ.
• Akuko banyere mmegharia nke aru.
• Mmanya na-aba n'anya nke ụdị adịghị ala ala.
• Ọkụ akwara afọ n’ala.
• Ọnọdụ ọjọọ nke mmadụ.
• Oge ime na lactation.
• Surgerywa ahụ mberede mberede.

Ngwakọta, ụdị ntọhapụ

Holetar bụ mbadamba okirikiri, ihe dị ntakịrị convex, nwere ọkwa maka nkewa dị mfe. Otu mbadamba nkume nwere milligrams 20 ma ọ bụ 40 nke arụ ọrụ. Ha dị mfe ịmata: usoro 20 mg bụ acha anụnụ anụnụ, 40 mg bụ akwụkwọ ndụ akwụkwọ ndụ. Otu igbe nwere mbadamba iri abụọ.

Ọrụ ukpa nke Holetar - lovastatin. Ihe ndị ọzọ mejupụtara mejupụtara aka inyeaka. Ndị a bụ lactose monohydrate, butyhydroxyanisole, stachi, cellulose, magnesium stearate. Ngwakọta nke Holetar 20 mg site na Holetar 40 mg dị iche na ntutu. Otu mbadamba 20 mg nwere E131 na-acha anụnụ anụnụ, 40 mg nwekwara odo odo E104 odo.

Omume ọgwụ

Ofkpụrụ nke ime ihe nke lovastatin dị mfe. N’ụdị ya, ọ dị ka enzyme HMG-CoA reductase dị mkpa maka njikọta cholesterol. Lovastatin na-ewere ọnọdụ ya na mmeghachi nke kemịkal nke sterol synthesis, na-akwụsị ya. Imebi nke cholesterol na - eduga nbelata ọkwa ya.

Ahụ mmadụ na-anwa imegwara maka ụkọ ihe ahụ site na ịkụda lipoproteins nwere obere protein. Ọnụ ọgụgụ ha na-agbada. Mmetụta nke abụọ nke iwere Holetar bụ mmụba nke lapoproteins dị elu “dị mma” (HDL).

Nsonaazụ nke ịgbanye uche nke cholesterol, lipoproteins - na - ebelata ohere nke ibute ọrịa atherosclerosis. Ọrịa a na-eme ihe megidere ọkwa dị larịị dị na ngwaahịa nke abụba metabolism.

Mmetụta antiatherosclerotic nke lovastatin na-eme ka ikike ya kawanye mma:

• mee ka arụ ọrụ dị n’ọbara arịa - endothelium,
• gbochie mmepe nke ọbara ọgbụgba,
• belata mbufụt.

A na-ahụta mmezi nke ọkwa cholesterol mgbe izu abụọ gachara. A na-eme nkwubi okwu ikpeazụ mgbe izu isii isii site na oge were mbadamba lovastatin (ọrụ kachasị). Site na kagbuo Holetar, ọkwa nke cholesterol na lipoproteins malitere ịba ụba, na-alaghachi na nke mbụ. Njirimara nke ogwu a bu ihe ejiri mara ya.

E jiri ya tụnyere ndị ọzọ na-egbochi HMG-CoA reductase inhibitors, lovastatin na-ewere nwayọ nwayọ. Oke nlele kacha elu nke Holetar edere n'ime awa 2-4. Mbelata nke ọkwa ahụ ruo 10% pụtara na otu ụbọchị. O di nwute, nke a abụghị naanị nsogbu nke ọgwụ. Ahụ na-emekwa ya nke ọma. Dabere na ntuziaka ahụ, ọnụọgụ mmịpụta bụ naanị 30%.

A napụrụ ọgwụ ahụ site na ahụ mgbu, mmamịrị. Holetar na-enwe ike ịbanye n'ime mgbochi placental. Ebe ọ na-arụ ọrụ imeju / akụrụ arụrụ ọrụ, ọ na-agbakọ n'ime ahụ.

Holetar: ngosipụta maka ojiji

Edere Lovastatin maka ndị ọrịa nwere nsogbu metabolism na-arịa ọrịa bụ ndị nri nri, mmega ahụ oge niile, na ịba ụba. Ọ ga-adị mkpa mmechu ihu ndị chọrọ iwere mbadamba ihe odide Holetar iji dozie nsogbu nke ịmalite ọrịa atherosclerosis, mana adịghị njikere ịgbanwe ụdị ndụ ha. Nsonaazụ ọgwụ ahụ ga-ekwe omume naanị ma ọ bụrụ na ị na-eso usoro nri n'oge usoro ọgwụgwọ.

Dịka ntuziaka ahụ si dị, a na-ewere Holetar iji mezie cholesterol, LDL, triglycerides maka:

• heterozygous familial hypercholesterolemia,
• hypercholesterolemia ІІва, ІІв dị ka Fredrickson si kwuo,
• gwakọtara hypertriglyceridemia na nnukwu ihe ize ndụ nke ibute ọrịa eriri afọ na atherosclerosis.

A na-atụ aro Lovastatin iji gbochie / mee ka ọ daa ngba nke nsogbu ndị a:

• atherosclerosis,
• Ọrịa ọrịa obi,
• obi ọgụ
• ọrịa strok
• anya nke angina ọgụ.

Ofzọ nke ngwa, usoro onunu ogwu

Iji dozie mmebi nke cholesterol metabolism, o zuru ezu iji otu nri mbadamba ihe nke Holetar na mgbede. Na oke doses, dọkịta nwere ike ịkwado imebi usoro ọgwụgwọ kwa ụbọchị gaa usoro abụọ.

Na hypercholesterolemia na-erughị ala, usoro izizi bụ 10-20 mg. Agbanyeghị, ọ bụrụ na kọlestrọl karịrị 7.8 mmol / L, ọgwụgwọ malitere na 40 mg. Mgbe izu isii isii gasịrị, nyochazie mmezi nke imebi. Ọ bụrụ na cholesterol ka dị elu, mụbaa usoro onunu ogwu. Ọkwa usoro nguzozi bu 20-40 mg, nke kachasi elu bu 80 mg. Na usoro onunu ogwu kachasi elu, onu ogugu doses di abuo.

Ntuziaka maka Holetar na-atụ aro belata dose ahụ ma ọ bụrụ na ọkwa cholesterol dara n'okpuru akara 3.6 mmol / L, na LDL - 1.94 mmol / L.

Usoro ọgwụgwọ Atherosclerosis na-amalite site na 20-40 mg. Ọ nwere ike ịbawanye usoro onunu ogwu nke Holetar ruo 80 mg. Ọ bụrụ na enweghi ike nweta nsonaazụ achọrọ, a na-eji ọgwụ ike ka dochie ọgwụ ahụ.

Tupu ịmalite were mbadamba lovastatin, ị ga-enyocha ọbara maka kọlestrọl ọnụ, LDL, VLDL, HDL. A na-eme nyocha ugboro ugboro n'oge usoro ọgwụgwọ iji nyochaa arụmọrụ ya.

Ọ bụrụ na onye ọrịa ahụ na-ewere cyclosporine, fibrates, vitamin PP (karịa 1 g / ụbọchị), oke ọgwụ Holetar agaghị agafe 20 mg.

N'ime oke mmebi imeju (iwepu CPK na-erughị 30 ml / min), a na-ewere Holetar na dose nke ruru 20 mg / ụbọchị.

Ntuziaka maka ojiji nke Holetar, nkọwa, analogues, ọnụahịa, nyocha

1. Ngwakọta na usoro onunu ogwu
2. Ihe na-egosi
3. Ihe ngbanwe
4. Nsonaazụ
5. Dodoụbiga ya ókè
6. Mmekọrịta na ọgwụ ndị ọzọ
7. Holetar - ntuziaka maka ojiji
8. Holetar - ọnụahịa
9. Holetar - analogues
10. Holetar - nyocha

Ndị na-agụ akwụkwọ anyị ejirila Aterol belata cholesterol. Thehụ ihe ndị ama ama n’ahịa a, anyị kpebiri inyefe ya n’aka gị.

Site na mmụba nke ịba ụba n'ime ahụ, ọrụ nke obi na akwara ọbara na-akawanye njọ, imeju na akụrụ na-ata ahụhụ. Iji belata itinye uche n'ihe ndị a na - emerụ ahụ na ahụ, ịkwesịrị ị drinkụ ọgwụ dị iche iche. Otu n'ime ọgwụ kachasị dị irè bụ choletar.

Nsonaazụ

Enwere ike inwe isi ọwụwa, anya ilu, mgbu afọ

• site na eriri afọ: mgbu afọ, afọ ọsịsa ma ọ bụ afọ ntachi, ọgbụgbọ, anorexia,
• sistemu ụjọ: isi ọwụwa, ọgbụgbọ, mgbu mgbu na ure, ike ọgwụgwụ, nsogbu ehighị ụra, ọhụhụ na uto,
• site na imeju: mmụba na bilirubin, ọkwa transaminases, alkaline fascatase ga-ekwe omume. Na mgbakwunye na nsonaazụ ndị edepụtara, enwere ike ịhụ mmeghachi omume nfụkasị. Mmepe myopathy na rhabdomyolysis na-esote bụ ụdi.
• sistem mọzụlụ nwekwara ike bụrụ ihe ejiri ọghọm ya. Ikekwe ọdịdị nke myalgia, ihe nro mgbu, myopathy, myositis, dermatomyositis. Ọ na-adịkarị ụke rhabdomyolysis nwere ike ịmalite,
• allergies nwere ike ime na ọrịa hypersensitivity, toxic epidermal necrolysis, itching akpụkpọ, ihe ọkụ.

Ike nwere mgbe ụfọdụ na-adalata, nnukwu akwara na-ada ada, akwara ozi, obi na-eto eto.

Dodoụbiga ya ókè

N'ihe banyere ịdoụbiga mmanya ókè, a na-akwụsị ọgwụ ahụ ozugbo. A na-eme ihe iji jigide ọrụ dị mkpa nke ahụ onye ọrịa ma kwụsị ị absorụ ọgwụ ahụ. Iji mee nke a, jiri unyi na-arụ ọrụ ma ọ bụ ọgwụ ike nri, mepụta gastric lavage.

Ọ bụrụ na enwere ihe ọghọm nke ịmalite myopathy na rhabdomyolysis, yana ọdịda akụrụ, a na-enye sodium bicarbonate intravenous na diuretic. Mgbe hyperkalemia mere, a na-a calụ calcium chloride ma ọ bụ calcium gluconate intravenously. A na-enye glucose na insulin, na n'ọnọdụ ndị ọzọ siri ike, hemodialysis.

Mmekọrịta na ọgwụ ndị ọzọ

Iji ọgwụ ahụ anticoagulants mee ihe oge ụfọdụ na-abawanye oge prothrombin, ya bụ, ohere nke ọbara ọgbụgba na-abawanye.

Ojiji nke niacin, ọgwụ mgbochi macrolide, yana ketoconazole, clofibrate, gemfibrozil na cyclosporine na-amụba ohere nke myopathy.

Nnukwu mkpụrụ osisi mkpụrụ osisi greepu na-eme ka uche nke lovastatin dị n’ọbara, nke nwere ike ibute mmepe nke myopathy.

Ọnụ ego na analogues

Analogs bụ ọgwụ ndị a:

• Cardiostatin
• Lipoford
• Atorvastatin - Teva,
• Lovastatin,
• Apextatin.

A na-emepụta Cardiostatin site na ụlọ ọrụ Russia Nizhpharm. Ihe na-arụ ọrụ bụ lovastatin.

Emebere Apextatin site na Canonfarm Production (Russia). Ọgwụ ahụ nwere ọtụtụ statins. Nke a na-abawanye arụmọrụ ya nke ukwuu.

Emebere Lovastatin site na Lekpharm, ụlọ ọrụ Belarus. Isi ihe na - arụ ọrụ bụ lovastatin.

Ọnụahịa nke statins na ụlọ ahịa ọgwụ dị iche iche nwere ike ịdị iche. Nke a bụ n'ihi ntinye uche nke ihe na-arụ ọrụ, ọnụ ọgụgụ mbadamba dị na ngwugwu yana oke azụmahịa.

Ekele Holetar na-eme ka ahụike dị mma

Dabere na ndị ọrịa, Holetar na-enyere aka belata nchịkọta nke cholesterol n'ime ọbara. Site na nsonaazụ ọgwụ ahụ, ọdịmma mmadụ na-adịwanye mma na ịrụ ọrụ ya na-abawanye.

Nsonaazụ

Ojiji Holetar, dị ka ọgwụ ọ bụla ọzọ, nwere ike ibute mmetụta ndị ọzọ na-achọghị na ahụ. Dịka ntuziaka ahụ si dị, usoro ahụ dị iche iche nwere mgbaàmà ha na usoro ha na - ahụkarị na statin a nwere ike ịkpasu.

• N’akụkụ nke usoro nri: ọgbụgbọ, nsogbu stool, obi mgbawa, ọnụ kpọrọ nkụ, mkparị ma ọ bụ ibelata agụụ na uto, mmetụta nke erughị ala na ihe mgbu n’afọ (na -eme n’ime afọ), ịba ụba ọrụ nke enzymes imeju - transaminases, pancreatitis, hepatitis.
• Ọrịa akwara ozi.
• Ọkpụkpụ akwara: n’ime ndị ọrịa n’otu oge eji agwọ ọrịa cyclosporine ma ọ bụ vitamin PP (nicotinic acid) na Holetar, rhabdomyolysis nwere ike ịmalite. Ọnọdụ a bụ myopathy dị egwu, nke a na-emebi mkpụrụ ndụ anụ ahụ. Mgbaàmà gụnyere ọgbụgbọ, ọgbụgbọ, na ọgba aghara obi, gụnyere coma.
• Site n'akụkụ onye nyocha ahụ: n'ihu anya enwere mmetụta nke “fogging”, cataract, degeneration na atrophy nke optic nerve fibers, mgbanwe mgbanwe nke oghere ya na ya na-eme ka ọ dịkwuo mma.
• Ọrịa Hematopoietic: Choletar nwere ike ibute anaemia na thrombocytopenia.
• Mmeghachi omume nfụkasị: ọnya anụ ahụ, urticaria, edema nke nfụkasị, ọrịa Lyell.
• Mgbanwe nke ụlọ nyocha na nyocha: ịba ụba nke lipids, alkaline phosphatase, creatine phosphokinase, bilirubin, enzymes imeju,
• Ihe ozo: mmepe nke akwara itu mgbe rhabdomyolysis, tachycardia, mgbu obi.

Jiri n’oge ime

Dị ka akọwara na ntuziaka dị na ngalaba mgbochi ahụ, n'oge ime ime, mgbe a na-enye nwa ara, a naghị eji Holetar.

Emebeghi nchekwa na ohere nke ọgwụ a emere ụmụaka. Ya mere, ekenyeghi Holetar n’aka umuaka.

Mmekọrịta na ọgwụ ndị ọzọ

Na mmekorita ya na ogwu ndi ozo, Holetar gosiputara uzo. Ntụziaka ahụ kọwara na mgbe ejikọtara ya na ọgwụ nje ọgwụ nke macrolide otu, nicotinic acid, ohere nke rhabdomyolysis na-abawanye. Cyclosporin nwere mmetụta nke ịba ụba ọnụ ọgụgụ nke statin metabolites na ọbara, na-abawanye nsị ha. Mgbe ejikọtara ya na ọgwụ anticoagulants, enwere ọghọm ọbara na ọbara ọgbụgba, ebe Holetar na-abawanye oge prothrombin nke coagulation ọbara.

Ọnụ ahịa ọgwụ ọjọọ

N'agbanyeghị ojiji a na-ahụ ebe niile na ọnụnọ oge niile na ntuziaka maka ahụike nke ndị ọrịa Holetar, ọnụahịa ọgwụ a abụghị nke kachasị ala. E jiri ya tụnyere ndị ọzọ statin, ọnụ ahịa ya dị n'etiti etiti ọnụahịa. Dabere na mpaghara ahụ, enwere ike ịzụta Kholetar na oke sitere na 290 ruo 350 rubles kwa otu, yana usoro nke 20 mg yana site na 350 ruo 400 rubles kwa otu nwere 40 mg. Maka ndị bi na Ukraine, ọnụahịa ahụ dịgasị iche na onu ogugu 250 na 350 UAH, otu obula, maka ịchikota doses nke 20 mg na 40 mg. Ọ dị mma ịmara na ịdị irè nke ọgwụ a zuru oke na-egosi na iwu usoro ọnụahịa dị otú a.

Analogs nke Holetar

N'ime ụlọ ahịa ọgwụ ị nwere ike ịchọta ọgwụ nke, site na ihe ha nwere, bụ analogs nke Cholethar nwere ọdịiche dị ntakịrị na njirimara na usoro ọgwụ nke ime ihe na ntuziaka. Ọgwụ ndị a gụnyere Cardiostatin, Lovastatin, Atorvastatin-Teva. Ndi dibia tozuru oke, na eme ihe ndi ozo, nyocha ya na inyocha ihe ndi ozo di iche iche banyere ogwu nke inyelata ahuhu.

Nyocha Nyocha

Fọrọ nke nta ndị ọrịa niile na-a Hoụ Holetar dịka ntuziaka dọkịta si hazie iji kwado nguzozi nke ịba oke, cholesterol na ọrịa ndị ọzọ cholesterol na-achọpụta mmetụta ọgwụgwọ dị mma na enweghị mmetụta ọ bụla. Dabere na nyocha ha, ụfọdụ nyeere ọgwụ ahụ ihe fọrọ nke nta ka ọ bụrụ ozugbo, ma ugbua n'oge mmalite nke ọgwụgwọ, nnwale ndị ahụ malitere ịlaghachi na nkịtị, akara nke hypercholesterolemia malitere ibelata. Ndị ọzọ na-ekwu na nsonaazụ ahụ pụtara oge ụfọdụ, oge ụfọdụ naanị n'izu nke abụọ ma ọ bụ nke atọ ọgwụgwọ.

Agbanyeghị, n'ọnọdụ abụọ, Holetar lowers mkpokọta cholesterol ma kwalite ịdị mma nke ndụ na ahụike nke ndị ọrịa na usoro nlele ziri ezi nke ndụmọdụ na ntụziaka niile nke dọkịta na-aga.

Ọgwụ kachasị mma iji belata cholesterol: ndepụta na ọnụahịa

Iko oke cholesterol n'ime ọbara mmadu bu ezigbo ihe ojoo nye ahu ike ya.

Mkpụrụ ahụ na-agagharị n'okirikiri ọbara, ma nwee ike idozi na akwara vaskụla, na-akpụ ihe akpọrọ cholesterol. Ha, n'aka nke ha, na-eyi egwu ikpuchi oghere nke ọbara na mmepe nke ọrịa ndị dị ize ndụ dịka nkụchi obi na ọrịa strok.

N'ime ndị agadi, ndị ọrịa nwere ọrịa vaskụla, yana ndị mmadụ nweburu nkụchi obi ma ọ bụ ọrịa strok, imechi arịa ndị ahụ nwere ike ibute nnukwu nsogbu ahụike, ma kpatara mmepe nke ọrịa ndị ọzọ nke usoro akwara obi. Iji belata ihe egwu a, ọ dị mkpa iji ọgwụ ndị belata cholesterol ọbara.

Agbanyeghị, ekwenti cholesterol ka ndi okacha mara amara kwesiri ya. Ojiji ha a na-achịkwaghị achịkwa na nleghara anya nke contraindications nwere ike ibute nsonaazụ na-enweghị atụ, ma na-agbagha ọnọdụ onye ọrịa. Mana echefula na yana usoro ọgwụgwọ na-achọghị nchegharị, ma ọ bụ na enweghị mkpa maka ndị dị otú ahụ, onye ọrịa ahụ kwesịrị ịtụle menu ya ma mee mgbanwe ụfọdụ n'ụzọ ndụ ya.

Etu esi wedata cholesterol di elu?

Iji belata cholesterol ọbara, nke mbụ, onye ọrịa kwesịrị ịhapụ nri kachasị emerụ ahụ. Nọgide na-enwe ụda nkịtị nke arịa ọbara dịkwa ezigbo mkpa, yabụ, anyị ekwesịghị ichefu abamuru nke egwuregwu na ịga n'èzí.

Usoro ọgwụgwọ na-achọghị mgbanwe na cholesterol dị ogologo dị ogologo, onye ọrịa kwesịrị ịdị njikere maka nke a. N'okwu a, ọ dị mkpa ka onye ọrịa ahụ mee ihe nhọpụta na ntuzi aka nke dibịa na-aga iji wee mee ka ọnọdụ ahụ ka njọ, n’emerụghị ahụike ya aka.

Yabụ, iji belata cholesterol ọbara, ị ga - emerịrị:

• hapụ ihe ọjọọ,
• belata oriri nnu,
• iwepu ma ọ bụ iwetulata oke abụba oriri riri,
• nye anụ abụba anụ kama anụ,
• mee ka ihe jupụta na menu na ngwaahịa sitere na fiber nke osisi,
• na-eri carbohydrates zuru ezu,
• Gbalịsie ike itinye nri bara ụba nke acid polyunsaturated na nri gị.

Ndepụta ngwaahịa amachibidoro gụnyere:

• ụdị sausages dị iche iche (gụnyere saus na sausages),
• kuki
• bred,
• achịcha
• na-apụta.

Nkewa

1. Nchịkwa mgbanwe nke Anion na ọgwụ ndị na -ebelata mmịcha (nnabata) nke cholesterol na eriri afọ.
2. Nicotinic acid
3. Probukol.
4. Fibrates.
5. Statins (3-hydroxymethyl-glutaryl-coenzyme-A-reductase inhibitors).

Dabere na usoro eji eme ihe, enwere ike ike ọgwụ iji belata cholesterol ọbara dị iche iche.

Ọgwụ ndị na-egbochi njikọ lipoproteins atherogenic ("cholesterol ọjọọ)":

• akpụ
• fibrates
• nicotinic acid
• probucol
• benzaflavin.

Nke pụtara na ọ na -ewe iwelata cholesterol na nri n'ime eriri afọ:

• usoro nke bile acid,
• njigide.

Ndị na-edozi metabolism nke na-abawanye “ọkwa cholesterol dị mma”:

Ndị na - eme usoro nke bile acids

Ọgwụ Bile acid na-ejikọ mkpụrụ ọgwụ (cholestyramine, colestipol) bụ mkpogharị mgbanwe anion. Ozugbo n'ime eriri afọ, ha "na - ejide" bile acid ma wepụ ya n'ahụ. Ahụ mmadụ malitere enweghị acid bile, nke dị mkpa maka ịrụ ọrụ nkịtị. Ya mere, n'ime imeju, a na-amalite usoro ịwakọta ha na cholesterol. A na - ewere cholesterol "n'ọbara, n'ihi nke a, itinye uche ya ebe ahụ na - agbada.

Cholestyramine na colestipol dị n'ụdị akwa. A ga-ekewa ọgwụ kwa ụbọchị ka ọ dị ntụtụ 2 ruo 4, na-eri site na dilring ọgwụ na mmiri mmiri (mmiri, ihe ọ juiceụ )ụ).

Anaghị etinye mkpụrụ osisi mgbanwe iji abanye n'ọbara, na-eme naanị na eriri afọ. Ya mere, ha dị mma nchekwa mana enweghị nnukwu mmetụta anaghị achọ ya. Ọtụtụ ndị ọkachamara kwenyere na ọ dị mkpa ịmalite iji ọgwụ ndị a agwọ hyperlipidemia.

Nsonaazụ gụnyere nsị, ọgbụgbọ na afọ ntachi, oche na-adịghị ala ala. Iji gbochie ụdị mgbaàmà ndị a, ọ dị mkpa iwelie oriri nke mmiri na nri (fiber, bran). Site na iji ọgwụ ndị a ogologo oge na oke doses, enwere ike imebi nnabata na eriri afọ nke folic acid na ụfọdụ vitamin, tumadi abụba.

Ọgwụ ndị na-egbochi ịmịnye mkpụrụ ndụ cholesterol

Site n’ibelata iwere cholesterol n’ihe oriri n’ime eriri afọ, ọgwụ ndị a na-ebelata itinye uche n’ime ọbara. Nke kacha dị irè n ’ị nweta ego a bụ guar. O bu ihe ndi ozo sitere na nkpuru nke hyacinth agwa. O nwere polysaccharide mmiri na-agbanye mmiri, nke na-akpụ jelii mgbe kọntaktị na mmiri nwere eriri afọ.

Guarem na - ewepu cholesterol ụmụ irighiri mgbidi na eriri afọ. Ọ na - eme ka mkpocha acid na - eme ka ihe ghara ịdị ike, na - eduga n'ịba ụba nke kọlesterol site n'ọbara banye na imeju maka njikọ ha. Ọgwụ na-egbochi agụụ iri nri ma na -ebelata oke nri ị na-eri, nke na-eduga n’ibelata oke ibu na oke oke mmiri. A na -emepụta Guarem na granules, nke ekwesịrị ịgbakwunye ya na mmiri mmiri (mmiri, ihe ọ juiceụ ,ụ, mmiri ara ehi). Shouldakingụ ọgwụ ahụ kwesịrị ijikọ ya na ọgwụ ndị ọzọ antiatherosclerotic.

Mmetụta ndị ọ na-enwe na-agụnye ịmịcha mmiri, ọgbụgbọ, mgbu n'ime eriri afọ, na mgbe ụfọdụ oche tọgbọ. Agbanyeghị, ha na-egosipụta obere, ọ na - adịkarị, na - aga n'ihu na - agafe onwe ha.

Holetar - ntuziaka maka ojiji

Holetar were ya:

• Ana mburu mbadamba nkume ndị ahụ ma were mmiri were hichaa ya.
• A na-ekpebi usoro onyonyo na oge ọgwụgwọ site n'aka ndị dibia bekee. Ọtụtụ mgbe, dọkịta na-edepụta mbadamba 1 n'otu oge nri, ọ bụrụ na ọ dị mkpa, dọkịta nwere ike ịbawanye usoro onunu ogwu (mana ọ bụghị ihe karịrị 80 mg nke lovastatin kwa ụbọchị).
• Site na ibelata cholesterol (rue 1400 mg kwa 1 lita) ma ọ bụ lipoproteins dị ala (ihe ruru 750 mg kwa 1 lita), ọ dị mkpa iji belata usoro ọgwụ choletar.
• Iji nweta oke ọgwụgwọ ọgwụgwọ kachasị, onye ọrịa ahụ ga-agbaso nri pụrụ iche na-ala ala cholesterol.
• Mgbe ị na-ewere choletar, mgbanwe na-arụ ọrụ nke enzymes imeju na-apụta, agbanyeghị, mgbanwe ndị a na-abụkarị obere ọgwụ. Agbanyeghị, ọtụtụ ndị dọkịta na-enye ndụmọdụ na agbanyeghị ka ha nyochaa ọrụ nke enzymes n'oge ọgwụgwọ site na enyemaka nke choletar, iji zere mmepe nke mmetụta ndị ọzọ.
• Ọ bụrụ na nsonaazụ ọ bụla apụta, mbelata ọgwụ ma ọ bụ ịkwụsị ya were choletar ga-ekwe omume.
• Holetar anaghị emetụta ọnụego mmeghachi omume, yabụ enwere ike iburu ya ndị ọkwọ ụgbọ ala, ndị ọkwọ ụgbọ ala na ndị ọzọ ndị ọrụ ha chọrọ ime ngwa ngwa.

Holetar - ọnụahịa

A na-ere Holetar na obere ngwugwu nwere plọg 2 nke mbadamba iri. Ọnụahịa ahụ dabere na mpaghara na ụdị mbadamba:

• Ndị bi na Moscow ga-akwụ ụgwọ 290 (20 mg nke lovastatin) na 350 rubles (40 mg nke lovastatin) maka ngwugwu 1,
• Ndị bi na St Petersburg maka ngwugwu 1 ga-akwụ ụgwọ 330 (20 mg nke lovastatin) na 360 rubles (40 mg nke lovastatin),
• Ndị bi na Novosibirsk ga-akwụ 350 (20 mg nke lovastatin) na 400 rubles (40 mg nke lovastatin) maka mkpọ 1,
• Ndị bi na Ukraine maka ngwugwu 1 ga-enye 250 (20 mg nke lovastatin) na 350 hryvnia (40 mg nke lovastatin).

Holetar - analogues

E nwere ọgwụ ndị a dị yiri holitar:

• Apextatin. A na-arụpụta mmemme site na ụlọ ọrụ Russia Canonfarm Production. Ihe mejupụtara ọgwụ a gụnyere ọtụtụ statins, nke na -ebelata oke cholesterol n'ime ọbara. Maka mbadamba 20, ị ga-enye 230-280 rubles.
• Cardiostatin. A na-eme mmepụta site n'aka ụlọ ọrụ Russia Nizhpharm. Isi ihe na - arụ ọrụ bụ lovastatin. Maka mbadamba 20, ị ga-akwụ 250-300 rubles.
• Lovastatin. Companylọ ọrụ Belarus Lekpharm na-arụ ọrụ na mmepụta. Isi ihe na - arụ ọrụ bụ lovastatin. Maka mbadamba 20, ị ga-akwụ ụgwọ 150-300 rubles.

Tulip - ntuziaka maka ojiji

Tulip bu ogwu nke nwere ogwu uda di ala: statins (reductase inhibitors) nke ano. Na agbanyeghi ojuju nke nkenke nke umu anumanu site na ndi ohuru ohuru nke ogwu n’ihi otu ihe ahu si aru mmadu, tulip n’obere uzo ulo ogwu kariri oru nke otutu na egbochi ya. Ihe omuma atu: 20 mg nke tulip kwekọrọ 35 mg nke lovastatin ma obu 40 mg nke fluvastatin. Akụkụ a dị mkpa ịtụle mgbe ị na-ede ọgwụ ị .ụ ọgwụ.

N'okpuru, aga-enye ntuziaka maka iji ọgwụ Tulip ọgwụ, nke na-enye ohere ikpebi ohere nke iji mbadamba ọgwụ maka ọrịa dị iche iche na ọnọdụ nje na-ejikọ na / ma ọ bụ na-eme ihe megide ọkwa dị elu nke cholesterol ọjọọ.

Ngwakọta na ụdị ntọhapụ

Tulip bụ ọgwụ iji ọgwụ mee ihe n'ụdị mbadamba ọgwụ dị iche iche. Usoro onunu ogwu nke mbadamba: 10 mg, 20 mg, 40 mg. Ọnụ ọgụgụ mbadamba na ngwugwu: 30 PC., 60 PC., 90 PC. Usoro onunu ogwu na onunu na aghazi ka ekwuputa ihe omuma.

Ngwakọta ọrụ: atorvastatin n'ụdị nnu nke calcium. Ndị nwere ihe mejupụtara mbadamba ụrọ na akpụkpọ ahụ ihe nkiri: lactose monohydrate, cellulose n'ọtụtụ ụdị, polysorbate, titanium dioxide (enwere ike iji agba agba ma ọ bụ ihe mejupụtara dị iche, dabere na onye mepụtara ọgwụ ahụ).

Pharmacodynamic na ọgwụ pharmacostatic

Orkpachara anya na oghere ọnụ na esophagus dị ntakịrị (ọ baghị elu karịa 2%) n'ihi ọnụnọ nke ihe nkiri na-enye nchebe. Nke dịkarịa ala, 98% na - aputa ihe na eriri afọ. Ọ bụ nke otu ọgwụ ọjọọ nwere nnukwu ogo nke absorption. Site na iwelata usoro iwere ihe a mgbe ị na-a theụ ọgwụ ahụ na nri, ma ọ bụ n'ime nkeji iri atọ na-esote mgbe ị risịrị nri.

Iri nri enweghi ihe di nkpa, ebe obu na o metaghi oke itinye uche n’ihe di n’ime ahu. Elebara anya atorvastatin kachasị na plasma ọbara dị ka ihe dị ka awa 1.5 mgbe ị theụsịrị ọgwụ ahụ.

Nke a bụ n'ihi eziokwu ahụ bụ na ntinye uche nke ihe na - eme ihe na - arụ ọrụ na plasma ọbara mgbe ị na - ewere mbadamba ná mgbede bụ ihe na - erughị otu ihe ngosi mgbe ị na - a theụ ọgwụ n'ụtụtụ, site na 25-35%. Ọ bụrụ na onye ọrịa ahụ nwere ọrịa imeju (nke kacha egbu egbu ma ọ bụ etiology ọgwụ), mkpokọta atorvastatin kachasị na plasma ọbara nwere ike ịgafe iwu ahụ ugboro 16, nke dị ize ndụ maka ndụ na ahụike. Na agbanyeghị, imeju nke imeju abụghị ihe mgbochi zuru oke na iwere Tulip, mana ọ dị mkpa ka ịdebe elekere mgbede nke iri nri mgbe ị risịrị ya na usoro kachasị mma.

A na-enweta njikarịcha mmịpụta site na ọnụnọ nke ihe nkiri eji egbusi nwayọ nwayọ na mbadamba ihe. A naghị atụ aro imebi mbadamba nkume ndị a, n'ihi na nke a nwere ike mee ka usoro mmịba ahụ maawanye ma mee ka nkesa na - arụ ọrụ na - arụ ọrụ na plasma ọbara, nke nwere ike ịkpalite mkpokọta ihe ndị na - adịghị mma. Usoro ị hasụ ọgwụ nwere mmetụta ọfụma na ọnụego absorption: ka ọnụọgụ ahụ dị elu, karịa ogo gị.

Ka muorusastatin nke eriri afọ na-amị atorvastatin, ihe na-arụ ọrụ na-abanye na plasma ọbara, ebe ọ na-ejikọ njikọ na protein. Mgbe ahụ enwere njem site na ahụ gị site n'ọbara ọbara ma kesaa akwara akụkụ. Tulip nwere oke nke na-ejikọ protin plasma - ihe ruru 99%.

Na-emegide ihe dị na mmetụta inhibitory na mbelata (HMG-CoA) na mkpokọta cholesterol njikọ, enwere mmụba n'ọnụ ọgụgụ ndị na-anabata imeju na-enwe mmetụta dị ala lipoproteins dị ala (LDL). Ndị na-anabata ihe, na-enye aka na mbugharị nke LDL, nke na -ebelata nchịkọta nke cholesterol ọjọọ n'ahụ ahụ mmadụ. Site na nhazi oge, enwere ike igosipụta arụmọrụ nke usoro biochemical nke na - eme n'okpuru atorvastatin dị ka ndị a:

• Onu ogugu nke onu ogugu cholesterol n’aru: 28 - 45%.
• Onu ogugu onu ogugu nke LDL n’ogugu: 40 - 65%.
• Onu ogugu onu ogugu nke mgbadata nke apoliprotein B ke aru: 30 - 50%.
• Onu ogugu nchikota nke TG n’aru: 12 - 35%.
• Onu ogugu onu ogugu na-abawanye na mkpocha nke lipoproteins di elu (HDL) na aru: 10 - 35%.
• Onu ogugu nke ịrị elu na mkpokọta apiloprotein A na ahụ: 12 - 35%.

Ihe ka ukwuu n'ime ọgwụ na-arụ ọrụ na-arụ ọrụ na-emetụta usoro metabolic na imeju. Mmezi extrahepatic anaghị abụkarị 10%. Nkeji ọkara bụ awa iri na anọ. Agbanyeghị, mgbasa nke metabolites, na-enye ohere iji nọgide na-enwe mmetụta ọgwụgwọ na-egbochi mmachi mbelata, na-adịgide ruo awa 20 ruo 30. A na - eme ezumike site na feces (ihe karịrị 96%) na mmamịrị (ihe ruru 4%). Umumikota ihe pere mpe ma a na-ahụkarị ya na usoro ọgwụgwọ gafere ọnwa isii. Ọ bụ ihe karịrị 1%.

Usoro onunu ogwu na nhazi

Ekwesịrị ịgwọ ọrịa ahụ, dịka otu usoro anaghị enye ọgwụgwọ dị egwu. A họrọ oge ọgwụgwọ ahụ dabere n'ụdị ọrịa / ọrịa, ebumnuche ebumnuche (usoro ọgwụgwọ na mgbochi) yana njiri mara onye ọrịa. Enwere ike ịnọchite anya oge ọrịa ahụ, dabere n'ụdị ọrịa ahụ na ebumnuche ebumnuche dị ka ndị a:

• Usoro Ọrịa obi: ọnwa 12 ruo 48
• Mgbochi ọrịa obi: site na ọnwa atọ ruo ọnwa iri atọ na isii.
• Usoro ọgwụgwọ nke ọrịa shuga: site na ọnwa 12 ruo 26.
• Mgbochi ọrịa shuga: site na ọnwa isii ruo ọnwa iri na asatọ.
• Usoro ọgwụgwọ nke ọbara mgbali elu: site na ọnwa 3 ruo ọnwa iri na asatọ.
• Mgbochi ọbara mgbali elu: site na ọnwa 2 ruo ọnwa iri na abụọ.
• Usoro ọgwụgwọ nke egbugbere ọnụ nke ụdị dị iche iche, nke ọrịa ndị ọzọ na-adịghị agbakọ ma ọ bụ ọrịa: site na ọnwa isii ruo ọnwa iri isii na isii.
• Mgbochi nke ụdị dị iche iche nke lipids, nke ọrịa ndị ọzọ na-adịghị na-arịa ma ọ bụ ọrịa na-arịa ya: site na izu abụọ ruo ọnwa atọ.
• Usoro ọgwụgwọ maka oke ibu: dabere na ọkwa ahụ site na ọnwa 6 ruo ọnwa 48.
• Mgbochi oke ibu na ọnụnọ nke ọnọdụ n'ihi usoro metabolic na-adịghị ala ala ma ọ bụ nguzozi mmiri-electrolyte na ahụ: site na ọnwa 3 ruo 24.

Denye ọgwụ a otu ugboro ma ọ bụ ugboro abụọ n'ụbọchị. Nhọpụta nke "Tulip" abụghị ihe ngosipụta maka iwepụ usoro ọgwụgwọ na-abụghị ọgwụ. Ebumnuche "Tulip" bụ ịkwalite ịdị mma nke ịgwọ ọrịa egbugbere ọnụ na -eme ka usoro mmega ahụ dị mma yana usoro mmega ahụ. Site na usoro ọgwụgwọ ogologo oge, a na-atụ aro ịmalite site na usoro onunu ogwu nke 10 mg wee rịa 80 mg site na nlele oge nke plasma cholesterol na hepatic transaminases. Site na usoro prophylactic ogologo, a na-atụ aro ịmalite iji ọgwụ ahụ na 10 mg, mana ịba ụba usoro onyunye karịa 80 mg adịghị mma. Usoro onunu ogwu nke Tulip dabere na oria a nwere ike igosiputa ya dika ndi a:

• Hyperlipidemia nke ụdị dị iche iche (ma e wezụga maka hyzycholesterolemia homozygous), nke ọrịa ndị ọzọ na-adịghị ma ọ bụ ọrịa metụtara: izu abụọ mbụ, otu ọgwụ Tulip na usoro onunu ogwu nke 10 mg. Na-esote, a ga-eme ule nyocha iji nyochaa mmetụta ọgwụgwọ. N'ihe gosipụtara zuru ezu, usoro ịba ụba ahụ agbagoro ruo 20 mg ma na-eme nchọpụta ahụ ka izu abụọ ọzọ gasịrị.Dabere na data enwetara: a na-edebe usoro on 20 mg (yana ọgwụgwọ zuru oke), a na-abawanye ọgwụ ahụ ruo mg 40 (na-ezighi oke ọgwụgwọ), a na-ebelata dose ahụ ruo 10 mg (ma ọ bụrụ na mmetụta ndị na-eso ya apụta). N'ime oke onunu ogwu nke 80 mg otu ugboro kwa ụbọchị, a na-enye Tulip iwu tupu ọnwa atọ ka mmalite ọgwụgwọ gasịrị.
• Homozygous hypercholesterolemia nke ụdị ketara eketa. Denye ma dozie usoro ogwu ahụ n'oge ọgwụgwọ - 80 mg. Obere obere adịghị enye ọgwụgwọ zuru oke. A na-atụ aro otu ọgwụ Tulip na mgbede obere oge tupu ịlakpu ụra. N'ihe banyere mmetụta dị iche iche na ichebe ha ruo ihe karịrị izu abụọ, ọ dị mkpa ịkagbu ọgwụ ahụ ma jiri ọgwụ analogues dochie ya.
• Ọrịa nke sistemụ mmadụ. Usoro ọgwụgwọ mbụ bụ 10 mg otu ugboro kwa ụbọchị n'ụtụtụ mgbe ị tetara. Mgbe otu ọnwa gasịrị, a na-ahapụ ị increaseụ ọgwụ ike ruo 20 mg - ugboro abụọ na-a drugụ ọgwụ kwa ụbọchị maka 10 mg n'ụtụtụ na mgbede. Ekwesịrị inyocha cholesterol na hepatic transaminases otu ugboro n'ọnwa. Dabere na ndị egosipụtara enwetara, a na-agbazi dose ahụ. Usoro ọgwụgwọ kachasị: 80 mg na usoro onyonyo kewara abụọ kwa ụtụtụ na mgbede.
• Mgbochi ọrịa dị iche iche na ọnọdụ pathologies: usoro ọgwụgwọ nke mbụ - 10 mg. Usoro onunu ogwu kacha bu Tulip 20 mg. A na-ahapụ ọgwụ a na usoro onunu ogwu nke 20 mg tupu ọnwa agaa mgbe usoro ọgwụgwọ gasịrị.

Mmekọrịta na ọgwụ ndị ọzọ

• Ọgwụ ndị na-egbu egbu “Erythromycin” na “Clarithromycin.” N'otu oge ị takingụ ọgwụ ndị a na Tulip na-eduga n'ịba ụba nke mkpokọta atorvastatin na plasma ọbara mmadụ dị ihe dị ka 50%. Ọ bụrụ na ọ dị mkpa ịde ọgwụ mgbochi usoro a, usoro ọgwụgwọ Tulip ga-ebelata.
• Ọgwụ hypolipidem nke otu ọgwụ ọgwụ na-abụghị statins. Ihe ọghọm nke ịrịa myopathy na rhabdomyolysis na-abawanye.
• Ihe mgbochi oral nke nwere ethinyl estradiol ma obu norethisterone. Enwere mmụba na mkpokọta ihe ndị na - arụ ọrụ nke ọgwụ mgbochi ahụ n'ime ahụ site na 20 - 40%, nke nwere ike ịkpalite enweghị usoro homonụ. Agbanyeghị, mbenata etu esi egbochi ọgwụ igbochi ọgwụ nwere ike kpasu oke nchebe ịbanye na ịtụrụ ime. N'akụkụ a, a na-atụ aro ịhọrọ ọgwụ mgbochi ndị ọzọ n'oge ọgwụgwọ Tulip.
• Ọgwụ antimycotic nke otu sozole. Enwere mmụba nke mkpokọta atorvastatin na plasma ọbara n'ihe dị ka 35%.
• Ọgwụ nke otu antacids. Nchoputa mbuba nke atorvastatin n'ime aru mmadu site na 30-40%.
• Cyclosporin. Iji otu oge eji Tulip mee ihe, o nwere ike kpalite mmụba nke atorvastatin n’ahụ mmadụ ugboro 6 ruo 10, dabere n’usoro nke ọgwụ. Anaghị anabata nchikota ọgwụ ndị a.
• Ndị na-egbochi nje HIV, nkwadebe nicotinic acid, fibrates - na-amụba ohere nke myopathy.
• Ihe ọ juiceụ Graụ mkpụrụ osisi grape. Iji ihe ọ juiceụpeụ mkpụrụ osisi na-eji mmiri ọgwụ eme ihe n’ime otu lita kwa ụbọchị maka ụbọchị 5 ma ọ bụ lita 0,5 kwa ụbọchị maka otu izu nwere ike ime ka ịta ụta nke mkpụrụ osisi nọ n'ọrụ "Tulipa". N'akụkụ a, a na-atụ aro ya maka oge ọgwụgwọ "Tulip" ịhapụ ị juiceụ mmiri mkpụrụ osisi grape.

Mmetụta akụkụ na ị andụbiga mmanya ókè

Ohere nwere ike ịdị n'akụkụ 10%: mmeghachi omume nfụkasị nke ụdị dị iche iche (ihe ngbu, itching, nkụda mmụọ na-adịghị ala ala nke akụkụ iku ume, wdg), isi ọwụwa, isi ọwụwa, mgbaàmà dyspeptik, ọgbụgbọ, afọ ntachi ma ọ bụ afọ ọsịsa, azụ mgbu, mgbu nkwonkwo (mgbe ụfọdụ ufe nta), hyperglycemia.

Ohere nke nsonaazụ akụkụ site na 1% ruo 10%: nsogbu ehighị ụra, ọnọdụ asthenic, adịghị ike nke izugbe, ọnwụ nke uto mmetụta, ọrịa ịba ọcha n'anya, ahụkarị na ọnọdụ ndị yiri ya, mkpọchi na tinnitus, mbelata ọhụụ nwa oge, hypoglycemia, fever, Secondal renal ọdịda. .

Ohere nke nsonaazụ ndị ọzọ ruru 1%: ujo anaphylactic, mfu ncheta, ọrịa shuga, mbibi akwara (na-ejikọkarị ya na azụ), mmebi imeju.

Ọ bụ obere. N'ihi nnwekọrịta dị elu nke ọgwụ ike na protein ndị na-enye plasma, ojiji nke hemodialysis anaghị enye arụ ọrụ dị mkpa. A na-eme ọgwụgwọ Symptomatic.

Anastasia, 34 afọ, nwunye

N'ehihie ọma Achọrọ m ịhapụ nyocha m banyere mbadamba Tulip. Agakwuuru m onye na-ahụ maka nri na-edozi ahụ nwere nsogbu oke ibu. Nri achụrụ esiteghị na nsonaazụ kwesịrị ekwesị - na mbụ o furu efu kilogram ole na ole, mana mgbe obere oge lọghachiri. N'ihi nke a, ezigara m maka nyocha zuru oke nke nyocha, nke nyere nkọwa zuru oke karịa - enwere m ị nweta oke cholesterol ọtụtụ oge karịa nke nkịtị. Edere m ụdị nri dị iche - na-emesi ike maka nri dị na cholesterol dị ala na nri ndị na-enyere aka belata cholesterol. Nsonaazụ nsonaazụ mechara bụrụ ihe adịghị mkpa. Ọkachamara na-abịa ihe a kwuru ka emee ọgwụ ọnwa isii nke ọgwụ Tulip. Ejiri m mg 10 ugboro abụọ n’ụbọchị. Anaghị m a theụ ọgwụ edenye m. Ka ọnwa atọ gachara, enwere ike ịgafe ebe kilogram laghachiri. Mgbe ezumike ọnwa gasịrị, a họpụtara usoro ọgwụgwọ ahụ kwa afọ "Tulip", ịga n'ihu na nri na usoro mmega ahụ. Ruo taa, a edozila nsogbu nke oke ibu, mana m na-aga n'ihu na ọgwụgwọ maka ndụmọdụ nke dọkịta, ebe ọ ka dị ihe dị ka ọnwa atọ.

Dmitry Ivanovich Krasnov, 67 afọ, lara ezumike nká

Kọmishọn nyere m ọgwụ Tulip, mgbe Lovastatin dị nkọ nke na-ewetaghị nsonaazụ kwesịrị ekwesị. Tulip nyere aka belata cholesterol, dọkịta kwuru. Enwere m obi iru ala nke usoro ISHB. Mwakpo ahụ belatara ugboro ugboro n'ọnwa nke anọ nke ị theụ ọgwụ ọjọọ. Mkpokọta, m were metaprolol bụrụ na enwere mmetụta nke ọnọdụ ịchụ nta ego. Uru ọzọ bụ na a nabatara ọnụahịa ahụ.