Ọgwụ Hinapril ọgwụ: ntuziaka maka ojiji

Ọgwụ antihypertensive, ACE inhibitor.

Quinapril hydrochloride bụ nnu nke quinapril, ethyl ester nke ACE inhibitor quinaprilat, nke na-enweghị ìgwè sulfhydryl.

Quinapril na-apụ ngwa ngwa na usoro nke quinaprilat (quinapril diacid bụ metabolite bụ isi), nke bụ ihe na-egbochi ike ACE. ACE bụ peptidyldipeptidase nke na-ejigide ntụgharị nke angiotensin I na angiotensin II, nke nwere mmetụta vasoconstrictor ma na-etinye aka na njikwa ụda olu na ọrụ site na usoro dị iche iche, gụnyere mkpali nke mmepụta aldosterone site na cortex adrenal. Quinapril na-egbochi ọrụ mgbasa na anụ ahụ ACE ma si otú ahụ belata ọrụ vasopressor na mmepụta nke aldosterone. Mbelata ogo angiotensin II site na usoro nzaghachi na-eduga n'ịbawanye n'ihe nzuzo ma na-arụ ọrụ na plasma ọbara.

A na-ahụta usoro kachasị mma nke mmetụta antihypertensive nke quinapril dị ka mgbochi nke ọrụ RAAS, agbanyeghị, ọgwụ ahụ gosipụtara mmetụta ọbụna na ndị ọrịa nwere ọbara mgbali ala. ACE bụ otu ihe ahụ na kininase nke abụọ, enzyme nke na-akụda bradykinin, peptide nwere akụrụngwa vasodilating siri ike. Ọ ka amabeghị ma mmụba nke ọkwa bradykinin dị mkpa maka ọgwụgwọ ọgwụgwọ quinapril. Ogologo oge antihypertensive mmetụta nke quinapril dị elu karịa oge nke inhibitory mmetụta ya na-agagharị ACE. E kpughere njikọ dị nso n'etiti mgbochi anụ ahụ ACE na oge nke ọgwụ antihypertensive.

Ndị na - egbochi ACE, gụnyere quinapril, nwere ike ịbawanye ohere insulin.

Ojiji nke quinapril na ọnụọgụ 10-40 mg na ndị ọrịa nwere nnukwu mgbali elu na-eduga n'ọbara dị elu ma na-anọdụ ala ma na -echekwa ma na-enwe ntakịrị mmetụta na ọnụego obi. Mmetụta antihypertensive na-egosipụta onwe ya n'ime otu elekere 1 ma na-ebutekarị ihe kachasị n'ime awa 2-4 mgbe ị takingụsịrị ọgwụ ahụ. N'ime ụfọdụ ndị ọrịa, a na-ahụkarị ọgwụ mgbochi oke ka izu abụọ gachara ịmalite ọgwụgwọ.

Mmetụta antihypertensive nke ọgwụ ahụ mgbe ejiri ọgwụ ndị a tụrụ aro ya na ọtụtụ ndị ọrịa na-ewe awa 24 ma na-adịgide n'oge ọgwụgwọ ogologo oge.

Ọmụmụ ihe metụtara akụrụngwa na ndị ọrịa nwere ọbara mgbali elu gosipụtara na mbelata ọbara mgbali n'okpuru mmetụta nke hinapril na-esonyere mbelata OPSS na nkwụghachi vaskụla, ebe ọnụego obi, ntụgharị obi, usoro ọbara gbasara akụrụ, ọnụego mkpo na mkpo ma na - agbanwe agbanwe ntakịrị ma ọ bụ agbanweghị.

Mmetụta ọgwụgwọ nke ọgwụ ahụ n'otu usoro onunu ogwu kwa ụbọchị nwere ike iji tụnyere ndị okenye (karịa 65) na ndị ọrịa nke okenye, na ndị okenye ugboro ole nke ihe ọjọọ adịghị arị elu.

Ojiji nke hinapril n’ime ndị ọrịa nwere nkụda mmụọ na-adịghị ala ala na-eduga na mbelata na OPSS, pụtara ọbara mgbali, systolic na ọbara mgbali, mmachi nke capillaries pulmonary na mmụba na mmepụta obi.

N'ime ndị ọrịa 149 na-arịa ọrịa akwara na-agagharị agagharị, ọgwụgwọ na quinapril na kilogram 40 kwa ụbọchị ma e jiri ya tụnyere placebo mere ka mbelata ugboro ugboro nsogbu ọgbụgba na-akpata nsogbu n'ime otu afọ mgbe a wasịrị ya ahụ.

N'ime ndị ọrịa nwere atherosclerosis akwara ozi nwapụtara na-enweghị ọbara mgbali elu ma ọ bụ nkụchi obi, quinapril na-eme ka ọrụ ngwụcha akwara dị na akwara ozi na akwara ike.

Nsonaazụ nke quinapril na ọrụ endothelial na-emetụta mmụba na mmepụta nitric oxide. A na-ahụta ọrịa endothelial dị ka usoro dị mkpa maka mmepe nke atherosclerosis. Egobeghi ihe nlebara anya nke imezi ọrụ endothelial.

Mlọ ọgwụ

Absorption, nkesa, metabolism

Mgbe abanyechara Cmax nke quinapril na plasma, a na-enweta ya n'ime otu awa 1. Ogo ogo ọgwụ a bụ ihe dịka 60%. Iri nri anaghị emetụta ogo mmịpụta, mana ọnụego na ogo nnabata nke quinapril belata ntakịrị mgbe ị na-eri nri abụba.

Quinapril bụ metabolized na quinaprilat (ihe dị ka 38% nke ọgwụ ọnụ) yana ọnụ ọgụgụ dị nta nke metabolites ndị ọzọ na-adịghị arụ ọrụ. T1 / 2 nke quinapril sitere na plasma dị ihe dị ka elekere 1. Cmax nke quinaprilat dị na plasma erutela ihe dị ka awa 2 mgbe ịpụsịrị quinapril. Ihe dị ka 97% nke quinapril ma ọ bụ quinaprilat na-agbagharị na plasma n'ụzọ ejikọtara protein. Hinapril na metabolites ya abanyeghị na BBB.

A na-apụtakarị Quinapril na quinaprilat na mmamịrị (61%) yana yana feces (37%), T1 / 2 bụ ihe dị ka awa 3.

Usoro usoro onunu ogwu

Mgbe ị na - eme monotherapy maka ọbara mgbali elu, ọgwụ a na - atụ aro ka ọ bụrụ nke Accupro® na ndị ọrịa na - anabataghị ọgwụ mkpirisi bụ 10 mg ma ọ bụ 20 mg otu ugboro n'ụbọchị. Dabere na nsonaazụ ụlọ ọgwụ, enwere ike ịba ụba (okpukpu abụọ) gaa na ndozi nke 20 mg ma ọ bụ 40 mg kwa ụbọchị, nke a na-edekarị na 1 dose ma ọ bụ ekewa n'ime akụkụ 2. Dịka iwu, ekwesịrị ịgbanwe dose ahụ na etiti oge izu anọ. N'ime ọtụtụ ndị ọrịa, enwere ike ịchịkwa ọbara mgbali zuru oke n'oge ọgwụgwọ ogologo oge site na iji ọgwụ 1 oge kwa ụbọchị. Oke kachasị kwa ụbọchị bụ 80 mg.

N'ime ndị ọrịa na-aga n'ihu na-a diụ mkpụrụ ọgwụ, a na-atụ aro ọgwụ mbụ nke Accupro® bụ 5 mg, n'ọdịniihu ọ ga-abawanye (dịka akọwara n’elu) ruo mgbe arụpụtara oke.

Na nkụda obi na-adịghị ala ala, eji ọgwụ a gosipụtara ka ọ bụrụ mgbakwunye ọgwụgwọ na diuretics na / ma ọ bụ cardiac glycosides. Usoro ọgwụgwọ akwadoro ka ndị ọrịa nwere nkụda mmụọ na-adịghị ala ala bụ 5 mg 1 ma ọ bụ ugboro abụọ kwa ụbọchị, mgbe ị takingụ ọgwụ ahụ, a ga-ahụrịrị onye ọrịa ahụ iji chọpụta hypotension art Symomatomat. Ọ bụrụ na nnabata nnabata mbụ nke Accupro® dị mma, mgbe ahụ enwere ike ịbawanye ya n ’ụzọ dị irè, nke na-abụkarị 10-40 mg kwa ụbọchị n’ime usoro ọnụọgụ abụọ nha n’ usoro ọgwụgwọ concomitant.

N'ọnọdụ ọrụ mmerụ ahụ na-adịghị mma, usoro ọgwụgwọ mbụ nke Accupro® bụ 5 mg na ndị ọrịa nwere CC karịa 30 ml / min na 2.5 mg na ndị ọrịa nwere CC na-erughị 30 ml / min. Ọ bụrụ na ịnagide ọgwụ mbụ ahụ dị mma, mgbe ahụ echi ọgwụ Accupro® ka a ga - edenye ya 2 Ọ bụrụ na enweghị nsogbu hypotension ma ọ bụ nnukwu nsogbu na ọrụ mkpo ya, enwere ike ịbawanye ọnụọgụ ahụ na oge izu, na-eburu n'uche ọgwụgwọ ahụ na mmetụta hemodynamic.

Nyere n ’data banyere ụlọ ọgwụ na ọgwụ ọgwụ n’ụlọ ọgwụ ndị ọrịa nwere nsogbu gbasara akụrụngwa, a na-atụ aro ka ebido ịhọrọ dịka ndị a.

Ofzọ nke ngwa

Dabere na nsonaazụ ụlọ ọgwụ, enwere ike ịba ụba (okpukpu abụọ) gaa na ndozi nke 20 ma ọ bụ 40 mg / ụbọchị, nke a na-edekarị na 1 ma ọ bụ 2 usoro. Dịka iwu, ekwesịrị ịgbanwe dose ahụ na etiti oge izu anọ. N'ime ọtụtụ ndị ọrịa, ị Hụ ọgwụ Hinapril-SZ 1 oge kwa ụbọchị na-enye gị ohere ịnweta nzaghachi ọgwụgwọ kwụsiri ike. Oke kachasị kwa ụbọchị bụ 80 mg / ụbọchị.
Obere oge iji diuretics: usoro a tụrụ aro ya nke Hinapril-SZ n’ebe ndị ọrịa na-aga n’ihu na-a diụ ọgwụ bụ 5 mg otu ugboro n’ụbọchị, emesịa ọ na-abawanye (dịka akọwara n’elu) ruo mgbe arụpụtara ezigbo ọgwụgwọ ọgwụgwọ.
CHF
Usoro akwadoro mbụ Hinapril-SZ bụ 5 mg 1 ma ọ bụ ugboro abụọ kwa ụbọchị.
Mgbe ọ takingụsịrị ọgwụ ahụ, onye ọrịa ahụ kwesịrị ịnọ n'okpuru nlekọta ahụike iji chọpụta hypotension arterial hypotension. Ọ bụrụ na anabatakarị ọgwụ mbụ nke Hinapril-SZ, enwere ike ịbawanye ya gaa 1040 mg / ụbọchị site na nkewa n'ime abụọ.
Renrụ ọrụ na-arụ ọrụ na ụlọ
Nyere n ’ụlọ ọgwụ na ụlọ ọgwụ ọgwụ gbasara ndị ọrịa nwere nsogbu gbasara akụrụngwa, a na-atụ aro ka ebido ịhọrọ ọgwụ ndị a:
Mgbe Cl creatinine karịrị 60 ml / min, ọgwụ a na-atụ aro ka ọ bụrụ 10 mg, 30-60 ml / min - 5 mg, 10-30 ml / min - 2.5 mg (1/2 tab. 5 mg).
Ọ bụrụ na ịnagide ọgwụ mbụ ahụ dị mma, mgbe ahụ enwere ike iji ọgwụ Hinapril-SZ mee ihe ugboro abụọ n'ụbọchị. Enwere ike ịba ụba nke Hinapril-SZ nke nta nke nta, ọ bụghị ihe karịrị otu ugboro n'izu, na-eburu n'uche ụlọ ọgwụ, mmetụta metụtara akụrụngwa, yana ọrụ akụrụ.
Ndị okenye na-arịa ọrịa
Thezọ mbụ a tụrụ aro Hinapril-SZ n’ebe ndị agadi nọ dị 10 mg otu ugboro n’ụbọchị, n’ọdị n’ihu ọ ga-abawanye ruo mgbe arụpụtara ezigbo ọgwụgwọ ọgwụgwọ.

Nsonaazụ

Ihe omume ojoo na quinapril na-adịkarị nwayọ ma nweekwa oge. Ọtụtụ mgbe, isi ọwụwa (7.2%), dizzness (5.5%), ụkwara (3.9%), ike ọgwụgwụ (3.5%), rhinitis (3.2%), ọgbụgbọ na / ma ọ bụ vomiting (2.8%) na myalgia (2.2%). Okwesiri iburu n’uche n’otu ihe atụ, ụkwara anaghị arụ ọrụ, na-adịgide, ma na-apụ n’anya mgbe ọ kwụsịrị ọgwụgwọ.
A chọpụtara ugboro ole mwepụ quinapril n'ihi nsonaazụ ya na 5.3% nke ikpe.
Ihe ndị a bụ ndepụta mmeghachi omume na-adịghị mma nke ndị sistemụ akụrụngwa kesara na oge ihe omume (nhazi ọkwa WHO): ọtụtụ mgbe karịa 1/10, ọtụtụ mgbe karịa 1/100 ruo ihe na-erughị 1/10, ugboro ugboro site na 1/1000 ruo ihe na-erughị 1 / 100, adịkarịghị - site na ihe karịrị 1/10000 erughị 1/1000, dịkarịsịrị obere - site na erughi 1/10000, gụnyere ozi nkeonwe.
Site n'akụkụ nke sistemụ akwara: mgbe mgbe - isi ọwụwa, dizziness, ehighị ụra nke ọma, paresthesia, ike ọgwụgwụ, adịghị ala ala - ịda mba, ịba ụba oke iwe, iro ụra, vertigo.
Site na ngwe nri: otutu oge - ọgbụgbọ na / ma ọ bụ ọgbụgbọ, afọ ọsịsa, dyspepsia, mgbu nke afọ, na - adịghị ala ala - akpukpo ahihia nke ọnụ ma ọ bụ akpịrị, flatulence, pancreatitis *, angioedema nke eriri afọ, ọbara ọgbụgba, ọnya afọ - obere ịba ọcha n'anya.
Ọrịa na nkwarụ izugbe na ebe a na-agbanye: enweghi mkpali - edema (akụkụ ma ọ bụ ịgbasa), ọrịa, ọrịa nje.
Site na sistem ọbara na lymphatic sistem: obere oge - hemolytic anaemia *, thrombocytopenia *.
Na akụkụ nke CVS: mgbe mgbe - mbelata ọbara mgbali elu, ugboro ugboro - angina pectoris, palpitations, tachycardia, nkụchi obi, myocardial infarction, ọrịa strok, ọbara mgbali elu, ujo cardiogenic, ọbara ọgbụgba *, nkụda mmụọ *, akara nke vasodilation.
Site na sistem iku ume, obi na akụkụ ahụ nke etiti: mgbe - ụkwara, dyspnea, pharyngitis, mgbu obi.
N’akụkụ anụ ahụ na akwara dị n’ime ala: ugboro ugboro - alopecia *, exfoliative dermatitis *, ịba ụba nke mmiri, pemphigus *, mmeghachi omume nke mkpụrụedemede *, itching, ihe ngbu.
Site n'akụkụ akwara na uru ahụ: oge ​​- mgbu azụ, ugboro ugboro - arthralgia.
Site na akụrụ na urinary tract: ugboro ugboro - urinary tract na-efe efe, nnukwu gbasara akụrụ odida.
Site na akụkụ ahụ anụ ahụ na gland mammary: ugboro ugboro - mbelata ikike.
Site n'akụkụ akụkụ ahụ nke ọhụ ụzọ: ọhụhụ - ọhụhụ ụzọ.
Site n'akụkụ akụkụ ahụ ji alụso ọrịa ọgụ: ugboro ugboro - mmeghachi omume anaphylactic *, adịkarịghị - angioedema.
Ndị ọzọ: adịkarịghị - eosinophilic pneumonitis.
Ihe ngosi nke ulo-akwukwo: ihe anaghi ahu anya - agranulocytosis na neutropenia, obu ezie na enwebeghi nsogbu bu ihe eji hinapril eme.
Hyperkalemia: lee "Ntụziaka pụrụ iche."
Creatinine na nitrogen urea ọbara: mmụba (karịa 1.25 ugboro ma e jiri ya tụnyere VGN) nke serum creatinine na ọbara urea nitrogen hụrụ na 2 na 2% nke ndị ọrịa na-anata monotherapy quinapril, karị. Ihe puru omume mmụba na paramita ndị a n’otu oge a na-anata ọgwụ n’otu n’otu karịa na iji quinapril naanị. Site na usoro ọgwụgwọ ọzọ, ndị na-egosi ihe na-alaghachikarị.
* - Mkpesa dị njọ ugboro ugboro ma ọ bụ mara n'oge nyocha na-azụ ahịa.
N'iji oge nke ACE inhibitors na nhazi ọla edo (sodium acurothiomalate, iv), akọwara ihe mgbaàmà, gụnyere ịkpụpụ ihu, ọgbụgbọ, ọgbụgbọ, na mbelata ọbara mgbali.

Ngwakọta na ụdị ọgwụ ahụ

Isi ihe dị na ọgwụ Hinapril bụ quinapril hydrochloride.

Ọzọkwa na mejupụtara ya enwere ụfọdụ ihe inyeaka:

• mmiri ara ehi shuga (lactose monohydrate),
• carbon magnesium dị mkpa
• primellose (skwọum croscarmellose),
• povidone
• stereta magnesium,
• aerosil (silloon silicon dioxide).

Ofdị ntọhapụ nke ọgwụ Hinapril bụ mbadamba okirikiri, nke mkpuchi ya na-acha odo odo na-ekpuchi. Ha bụ biconvex ma nọrọ n'ihe ize ndụ. Na mpaghara obe, isi ahụ nwere agba ọcha, ma ọ bụ nke na-acha ọcha.

A gosipụtara ọgwụ a na ngwugwu ọnya nwere 10 ma ọ bụ 30 mbadamba. Enwekwara ya na ite na karama ejiri ihe eji eme polymer.

Ihe ngosi maka ojiji

Edere mbadamba ihe Hinapril maka ịgwọ ọrịa dịka:

Enwere ike iji ọgwụ a ma na ọgwụgwọ ọgwụ mono, yana yana yana beta-blockers na thiazide diuretics.

Mmekọrịta na ụdị ọgwụ ndị ọzọ

Ka ị na-a medicationụ ọgwụ Hinapril na nkwadebe nke lithium, ndị ọrịa nwere ike ịbawanye ọdịnaya lithium na ọbara ọbara. Ihe ize ndụ nke mmanya ịhiụ mmanya na-abawanye n'ihe banyere njikwa nkwonkwo ya na ndị ọrụ diuretic.

Ihe jikọtara ọnụ na quinapril na ọgwụ hypoglycemic na-eduga n'ịbawanye n'ọrụ ha.

A nabataghị iji mbadamba ihe ndị a na nkwadebe nwere ethanol. Nsonaazụ ọjọọ nke mmekọrịta a bụ mmụba dị ukwuu na mmetụta antihypertensive.

Dodoụbiga ya ókè

Ọ bụrụ na onye ọrịa ewere ihe dị elu karịa ọgwụ mgbochi Hinapril nke nwere ike ime, nke a nwere ike ibute mbelata nke ukwuu n'ọbara ọbara, arụ ọrụ ọhụhụ, adịghị ike izugbe na anya mmiri.

N'ọnọdụ ndị dị otú a, ọ dị mkpa ịme ọgwụgwọ ọrịa Symptomatic ozugbo na nwa oge jụ ị .ụ ọgwụ.

Inwere ike ịmalitegharịa oge a naanị mgbe ị gachara dọkịta.

Ihe ngbanwe

Mpempe akwụkwọ Hinapril na-contraindicated na:

• anabataghị akụkụ nke ọgwụ ahụ,
• ọrụ ezughi oke,
• hyperkalemia
• akụkọ banyere anakedeede,
• angioedema, nke bu ihe ekere eke ma obu ihe anakpo ya na odidi,
• ọrịa shuga
• ime na lactation.

Na mgbakwunye, ọgwụ a ka edeghị maka ọgwụgwọ nke ndị ọrịa na-erubeghị afọ 18.

Usoro na ọnọdụ nchekwa

Ndụ nchekwa nke mbadamba nkume Hinapril bụ afọ atọ site na ụbọchị a rụpụtara. Ọ na-atụ aro ịchekwa ha na okpomọkụ ruo ogo 25 +, n'ebe ụmụaka anaghị enweta ya, na-atụkwasị obi na ọkụ na mmiri.

Na ụlọ ahịa ọgwụ Russia ịzụta ọgwụ Hinapril, ị ga-eweta ọgwụ. Ọnụ ego nke mbadamba nkume ndị a dị ala ma dị 80-160 rubles n'otu ngwugwu.

Na Ukraine Ọnụ ego nke Hinapril dịkwa ala - ihe dịka 40-75 hryvnia.

N'ime ụlọ ọrụ na-emepụta ọgwụ ọgbara ọhụrụ, a na-ewepụta ọtụtụ analogues ọgwụ nke hinapril. Ndị kachasị ewu ewu ma chọọ ha gụnyere:

A naghị atụ aro ka ị jiri ụdị nke Hinapril mata aha ya. Maka ebumnuche ndị a, ị ga-agakwuru dọkịta ruru eru nke ga-edenye nhọrọ kachasị mma dabere na mgbaàmà ahụike yana njirimara onye ọrịa niile.

Hinapril ọgwụ ahụ na-enweta nyocha dị mma n'ihi ịdị elu ya, ọnụ ala ọnụ na ntachi obi dị mfe site na ọtụtụ ndị ọrịa.

Ndị ji ọgwụ ndị a maka ebumnuche prophylactic na ọgwụgwọ, rịba ama na hinapril n'ụzọ dị mfe ma belata ọbara mgbali n'ụzọ dị mfe ma na-ebelata ọnọdụ ahụ na nkụchi obi na-adịghị ala ala. Obere nsonaazụ na - ejikọkarị yana enweghị nrube isi n'iwu nke ị theụ ọgwụ.

Inwere ike iguta ihe banyere okwu na ihe nlele na njedebe nke edemede a.

Ọ bụrụ na ị maara ọgwụ ahụ Hinapril nke ọma, were obere oge wee hapụ nyocha gị gbasara ya. Nke a ga - enyere ndị ọrụ ndị ọzọ aka mgbe ị na - ahọrọ ọgwụ.

Mmechi

Ọ bụrụ na ị na-eme atụmatụ ị theụ ọgwụ ahụ Hinapril maka ebumnuche ọgwụgwọ ma ọ bụ prophylactic, jide n'aka na ị ga-eburu n'uche njirimara ya.

1. Hinapril dị n'ụdị mbadamba maka iji ọnụ.
2. Dabere na nchoputa na ọnọdụ onye ọrịa, ọgwụ mbụ nke ọgwụ a bụ 5 ma ọ bụ 10 mg. Ka oge na-aga, n'okpuru nlekọta dọkịta, enwere ike ịbawanye elu site na nkerisi n'ụzọ abụọ.
3. Ihe kachasị ị dailyụ ọgwụ kwa ụbọchị bụ 80 mg.
4. Anabataghị ị takeụ ọgwụ a maka ụmụ nwanyị n'oge ime na lactation.
5. Ọ bụrụ na ị doụbiga ọgwụ ike ókè, mbelata ọbara mgbali elu na mbelata adịghị ike n'ozuzu enwere ike. Iji wepu onodu a, achoro usoro ọgwụgwọ Symptomatic.
6. Edeghị Hinapril maka ndị ọrịa na-eto eto na-erubeghị afọ 18.
7. Nchịkọta ojiji nke mbadamba nkume Hinaprir na ọgwụ nwere lithium na ethanol bụ ihe anabataghị.

Ogwu ogwu

Dịka anyị kwurula, ekwesịrị ị takenụ ọgwụ ahụ ọnụ. Awingụ mbadamba ihe dị oke mma. Jiri mmiri ọ Drinkụ Drinkụ itụọ ya. Usoro onunu ogwu a dabere na oria onye oria ya na ya na-agha.

Site n'ọbara mgbali elu, a na - enye monotherapy ọgwụ. N'okwu a, ịkwesịrị ị takeụ 10 mg nke “Hinapril” otu ugboro n'ụbọchị. Mgbe izu 3 gasịrị, a na-anabata mmụba nke usoro kwa ụbọchị ruo 20-40 mg. Enwere ike ekewa ya n'ime usoro onyonyo abụọ mgbe oge nke ruru.

Ọ bụrụ na achọrọ, ka ọgwụ a nye onye ọrịa nwere ọbara mgbali elu ka ọ gbagoro 80 mg. Usoro ndị a na-adịkarị mkpa ma ọ bụrụ na, mgbe izu atọ gachara ịmalite ọgwụgwọ, ahụghị mgbanwe dị mma.

N'ihe banyere ọrịa obi na-adịghị ala ala ma ọ bụ nnukwu olu, a na-atụ aro ịmalite iji Hinapril na 5 mg. N'oge usoro ọgwụgwọ, a chọrọ ka ọ nọrọ n'okpuru nlekọta nke ọkachamara iji chọpụta oge mmepe nke hypotension na onye ọrịa.

Ọ bụrụ na ọnọdụ ahụ na nkụchi obi anaghị agbanwe agbanwe, usoro ị increasedụ ọgwụ ahụ na-abawanye 40 mg kwa ụbọchị. Ndị dọkịta na-ede nyocha banyere ọgwụ na-egosi mgbanwe n'ọnọdụ ahụ ka ọ ka mma karịa ngbanwe dị otú ahụ na usoro ọgwụgwọ.

Ọ dị mkpa ịillsụ ọgwụ n’otu oge.

Jiri na nwata na nká

A machibidoro ị medicationụ ọgwụ ahụ maka ndị na-erubeghị afọ 18. Ya mere, eji ya eme ihe n’oge nwata di ka ihe anakwere.

Ndị ọrịa dị ihe karịrị afọ 65 kwesịrị ibido were ọgwụ were 10 mg. Mgbe nke a gasịrị, a na-anabata mmụba ya ruo oge oge egosipụtara ọgwụgwọ dị mma.

Tupu ịmalite usoro ọgwụgwọ ahụ, onye ọrịa merela agadi ga-enyocha ule n'ụlọ ọgwụ. Nke a bụ ihe ga-eme gị obi ike na nchekwa nke ọgwụgwọ ya na Hinapril.

Ọ dị mkpa ka e nyochaa ndị ọrịa agadi tupu ịmalite ọgwụgwọ

Pathology nke imeju na akụrụ

Ndị ọrịa nwere ọrịa imeju na akụrụ nwere ike ị theụ ọgwụ ahụ, mana n'okpuru nlekọta zuru oke nke dibịa na-aga. Usoro ọgwụgwọ dị otú a ga - anabata naanị maka ọrịa ụfọdụ na - akpaghasị ọrụ nke akụkụ ahụ dị n'ime. Ọ bụrụ n’ịdị, ịchọrọ iji nlezianya nyochaa usoro onodu ogwu nke "Hinapril" na agbanyeghị iji mee ka ọ dịkwuo elu na-enweghị mkpa yana ịnweta ikike ọkachamara.

Ntụziaka pụrụ iche

Ntụziaka maka ojiji nke “Hinapril” nwere ntuziaka pụrụ iche a ga-eburu n'uche mgbe ị na-ede usoro ọgwụgwọ dabere na ọgwụ a.

Enweghị ike iji ọgwụ ahụ n’oge ọ bụla dị ime. Ndi nwanyi nke omumu, o ghaghi iwere ogwu mgbochi oge a n’oge inwe nmeko. Ọ bụrụ na ime mere ozugbo n'oge nchịkwa Hinapril, onye ọrịa ahụ kwesịrị ịhapụ ịhapụ iji ya ọzọ. Ngwa ngwa ogwula ogwu ahu, ihe ojoo o gha eme ga-emere nwa ebu n’afọ na nne di ime.

Edere ikpe mgbe a mụrụ nwatakịrị n’enweghi nsogbu ọ bụla. N'ọnọdụ dị otú ahụ, a na-eji nlezianya nyochaa ụmụaka ndị nne ha drugụrụ ọgwụ a. Ndị dọkịta nwere mmasị karịsịa n'ọbara ọbara nwa ọhụrụ.

N'iji nlezianya na -eme ọgwụ, a na-enye ndị ọrịa a chọpụtara na ha nwere nsogbu gbasara akụrụngwa ma ọ bụ ọrụ hepatic. A na-ewere ọgwụ ndị dị n'ọrịa ndị dị otú ahụ naanị na usoro usoro akọwadoro. Ọzọkwa, a na-elebara onye ọrịa ahụ anya oge ụfọdụ, nke na-enye ohere ịchọpụta oge nbilata nke ọnọdụ nke akụkụ ahụ dị na ya nke nsogbu n'ihi ọgwụgwọ Hinapril.

Mkparịta ụka ọgwụ ọjọọ

Ọ bụrụ na iji ọgwụ ahụ na tetracycline were otu oge, ị nwere ike nweta nnukwu mbelata na nnabata ihe nke abụọ. Mmetụta a bụ n'ihi ọrụ pụrụ iche nke magnesium carbonate, nke na-arụ ọrụ dị ka ihe inyeaka na Hinapril.

Ọ bụrụ na onye ọrịa ahụ ewere lithium ya na ndị na - egbochi ACE, mgbe ahụ ọdịnaya nke ihe izizi na ọbara ọbara na-abawanye. Ihe ịrịba ama nke ịxụbiga mmanya ókè na - ebilite site na ụba uto sodium. Ya mere, achọrọ iji ọgwụ ndị a na-akpachapụ anya ma ọ bụrụ na ọ dị mkpa, nchịkwa nkwonkwo.

A na-ahapụ ka o jiri ya mee ihe n’otu n’otu na Hinapril. Ma n'otu oge ahụ enwere mmụba na mmetụta hypotensive. Yabụ, achọrọ iji nlezianya họrọ usoro ọgwụ abụọ ahụ iji zere nsogbu ahụike nke ọrịa onye ọrịa.

Cakpachara anya ma nwee ike ịchịkwa ọkwa nke potassium na ọbara, n’otu oge ị aụ ọgwụ na ọgwụ nke ndị otu ọgwụ na-eme ka potassium pụta. Ihe ndị na-enye mmadụ n’ahụ́ na ihe ndị na-enye nnu, na-enwekwa nnu, bụ otu.

Site na nhazi oge nke ọgwụ na mmanya, a na-achọpụta mmụba nke ihe ahụ na-arụ ọrụ “Hinapril”.

Mbadamba ụbụrụ na-eme ka ọgwụ a dị ike ugboro ugboro, nke ya na ị isụbiga mmanya ókè

Ọgwụgwọ na inhibitors ACE nwere ike iduga n'ọrịa hypoglycemia na ndị ọrịa. A na-ahụkarị ihe ịtụnanya a na ndị nwere ọrịa shuga na-a insụ insulin ma ọ bụ ọgwụ hypoglycemic maka ojiji nke ime. Ogwu a ga - eme ka ha nwekwuo mmetụta.

Ugboro ugboro iji ọgwụ ahụ na ọnụọgụ 80 mg yana atorvastatin na usoro nke 10 mg anaghị eduga mgbanwe dị ukwuu na ọrụ nke ihe nke abụọ.

Ogwu nwere ike ime ka o nwekwuo udiri oria leukopenia n’ime ndi oria n’otu oge n’eji allopurinol, immunosuppressants, ma obu ogwu cytostatic.

Ime ka ihe siri ike dị na Hinapril pụta bụ nke a na-ahụ anya mgbe ejikọtara ya na analgesics narcotic, ọgwụ anesthesia izugbe na ọgwụ antihypertensive.

Ihe mgbochi RAAS nke okpukpu abuo na-ebute ochichi nke aliskiren ma obu ACE inhibitors n’otu oge. A na-ahụkarị mmetụta na-adịghị mma megide mmalite nke ọbara mgbali elu, yana mmepe nke hyperkalemia.

Ọkachamara na-akwado ike ndị ọrịa ka ha zere ijikọ ọgwụ na aliskiren na ọgwụ nwere ọgwụ a, yana ọgwụ ndị na-egbochi RAAS n'ọnọdụ ndị a:

1. Na ọnụnọ nke ọrịa shuga mellitus mebiri akụkụ ahụ, yana enweghị ụdị nsogbu ahụ.
2. Ọ bụrụ na arụ ọrụ ezughi oke ọrụ,
3. Site na mmepe nke steeti hyperkalemia, nke ndị na-egosi ihe karịrị 5 mmol / l,
4. Site na nkụchi obi na-adịghị ala ala ma ọ bụ mmepe nke ọbara mgbali elu.

Ọgwụ ndị na-eduga n'ịbido ọrụ ụmị ọkpụkpụ na-eme ka ohere nke agranulocytosis ma ọ bụ neutropenia nwee ike.

Ndị ọrịa na-agwakọta ọgwụ ahụ na estramustine ma ọ bụ DPP-4 inhibitors nọ n'ihe ize ndụ nke ịmalite ọrịa angioedema.

Analogs na ọnụahịa

Otu analogues nke hinapril nwere otu ihe eji eme ihe

Purchasezụta Hinapril n'ụlọ ahịa ọgwụ, ị ga-ewetara ndị dọkịta ọgwụ ndenye ọgwụ sitere na dọkịta. Ọnụahịa ya dabere na ọnụ ọgụgụ mbadamba na ngwugwu a zụrụ. Onu ogugu nke ogwu a nwere ego di ka 80-160 rubles. Enwere ike ịchọta ndepụta ọnụahịa zuru ezu maka ọgwụ ahụ n'ụlọ ahịa ọgwụ.

Maka ụfọdụ ebumnuche, ndị dọkịta gbanwere ọgwụ edepụtara onye ọrịa ahụ ka ọ na-analog. A na-enye ọgwụ ndị a iji dochie Hinapril:

Analogs nwere ike ịhọrọ naanị dọkịta na-abịa. Onye ọrịa ahụ ekwesịghị ime nke a n'onwe ya, ebe ọ nwere ike imehie ihe nke ga-emetụta ọgwụgwọ na ahụike ya n'ozuzu ya.

Ọ bụrụ na n'ihi ihe ụfọdụ, onye ọrịa ahụ adabaghị ọgwụgwọ maka Hinapril, ọ kwesịrị ịgwa dọkịta na-aga ya banyere ya. Ọ ga-anwa ịhọrọ ọgwụ dabara adaba maka ya, na-elekwasị anya na nsogbu onye ọrịa na ọnọdụ ahụ ike ugbu a. Dịka iwu, ụdị agụụ ahụ na-ebilite ma ọ bụrụ na onye ọrịa nwere contraindications iji were ọgwụ ma ọ bụ mmepe nke mmeghachi omume na-adịghị mma site n'ahụ ahụ na-arụ ọrụ nke ọgwụ ahụ.

Khinapril bidoro ịnata ya ọbụlagodi mgbe a na-agwọ ya n'ụlọ ọgwụ. Dọkịta ahụ na-enyocha ọnọdụ m mgbe niile, ebe ọ na-atụ egwu nsonaazụ ọjọọ n'ihi nsogbu akụrụ. Ọ dabara nke ọma, enweghị nsogbu gosipụtara onwe ha. N’ozuzu, agara m were ọgwụ ahụ ihe dị ka ọnwa isii. Ọtụtụ mgbe, na nkwado nke dọkịta, mụbara usoro ọgwụgwọ ya. Ihe “Khinapril” zuru ezu, ebe ọ bụ na o nyere aka idozi nsogbu ahụ na ọbara mgbali elu, nke na-enye nsogbu n'oge na-adịbeghị anya. Ọ bụ ezie na oge ụfọdụ, ọbara mgbali ka na-ebili, ọ bụ ezie na ọ bụghị karịa tupu ịmalite ọgwụgwọ ọgwụ.

Amalitere m inwe nsogbu na nrụgide n’oge. Ọ bụ ezie na ọ na-abụkarị ọrịa ndị dị otú ahụ na-enye ndị agadi nsogbu. Dọkịta tụrụ aro ka ya na Hinapril lụso ha ọgụ. Ọ dọrọ aka ná ntị ozugbo banyere ihe ọ bụla nwere ike ịba na ya pụta, ya mere, o depụtara obere ọgwụ ọ bụla. Ejiri m ọgwụ a dịka ọgwụgwọ mmezi. Ihe niile na-aga nke ọma. Mana n'oge na-adịbeghị anya, ụra efu na-enweghị isi malitere ichegbu onwe m, ọ bụ ezie na m na-achọ inweta ụra zuru oke. Nke a bụ naanị mmetụta dị n'akụkụ nke merela onwe ya. Ọ bụrụ na ọnọdụ ahụ agbakeghị, a ga m arịọ dọkịta ka o nye m aha ana - akpọ "Hinapril," ebe mmeghachi ahụ nke ụdị ahụ adabaghịrị m ma ọlị.

Nhazi ọkwa nosological (ICD-10)

Mlọ ọgwụ

ACE bụ enzyme nke na - egbochi ntụgharị nke angiotensin I na angiotensin II, nke nwere mmetụta vasoconstrictor ma na - abawanye ụda olu, gụnyere n'ihi mkpali nke nzuzo nke aldosterone site na cortex adrenal. Quinapril na-asọmpi na-egbochi ACE ma na-eme ka mbelata ọrụ vasopressor na nzuzo nke aldosterone.

Kpochapu ihe ojoo anakpo angiotensin nke abuo na renin secretion site na nzaghachi nzaghachi na-eduga nbawanye na oru plasma renin. N'otu oge ahụ, mbelata ọbara mgbali so na mbelata obi obi na iguzogide akụrụ, ebe mgbanwe mgbanwe n'ọbara obi, mmepụta obi, obara ọbara gbasara ọnụego yana Mpekere nke mgbaze adịghị obere ma ọ bụ anọghị ya.

Hinapril na-abawanye nnagide mmega ahụ.Site n'iji ogologo oge mee ihe, ọ na-akwalite mgbanwe mgbanwe nke ọbara mgbali myocardial na ndị ọrịa nwere ọbara mgbali elu, na-eme ka ọbara nwetaghachi ischemic myocardium. Na-eme ka ọbara na -akpata ọbara na akwara. Na-ebelata nchịkọta platelet. Mmalite nke ị afterụchara otu ọgwụ dị ka elekere 1 gachara, nke kachasị mgbe awa 2-4 gachara, oge ihe a ga -eme dabaa n of ọgwụ ole enyerela (ruo awa 24). A na - enwe mmetụta dị n'ụlọ ọgwụ na-amalite ọtụtụ izu mgbe ịmalite ọgwụgwọ.

Ime na lactation

A na - egbochi ọgwụ iji Hinapril-SZ mee ọgwụ n'oge afọ ime, n'ime ụmụ nwanyị na - eme atụmatụ ịtụrụ ime, yana na ụmụ nwanyị toro afọ na - ejighị ụzọ ntụkwasị obi nke igbochi.

Womenmụ nwanyị dị afọ iri na ụma na-ewere Hinapril-SZ kwesịrị iji ụzọ ịtụkwasị obi nke igbochi afọ ime.

Mgbe a na-achọpụta afọ ime, ekwesịrị ịkwụsị ọgwụ Hinapril-SZ ozugbo enwere ike.

Ojiji nke ACE n’oge ịtụrụ ime ya sokwa ihe ọghọm nke njọ n’aka sistem na akwara ozi nke nwa ebu n’afọ. Na mgbakwunye, megide ndabere nke ị inụ ọgwụ mgbochi ACE n'oge afọ ime, akọwapụtara ikpe gbasara oligohydramnios, ịmụ nwa, ọmụmụ ụmụaka (hypotension hypotension), akụrụ gbasara akwara (gụnyere ọrịa akwara siri ike), hypoplasia cranial, nkwekọrịta aka na ụkwụ, ọrịa craniofacial, ọrịa hypoplasia, retraation intrauterine. mmepe, emepe ductus arteriosus, yana ọnwụ nwa ebu n'afọ na ọnwụ nke amụrụ ọhụrụ. Ọtụtụ mgbe, a na-achọpụta oligohydramnios mgbe nwa ebu n'afọ mebiri emebi nke ukwuu.

A ga-elebara ụmụ amụrụ ọhụrụ ndị ekpughere ACE na utero anya iji chọpụta hypotension, oliguria na hyperkalemia. Mgbe oliguria pụtara, ekwesịrị idobe ọbara mgbali elu na mmanu isi akụrụ.

Ekwesighi ịde ọgwụ ahụ Hinapril-SZ n'oge ị na-enye nwa ara n'ihi eziokwu ahụ bụ na ndị na-egbochi ACE, gụnyere hinapril, na-abanye n'ime mmiri ara. Nyere ohere nke imeputa ihe ojoo di ime n’ime nwa amuru ohuru, ogwu ogwu Hinapril-SZ aghaghi igbari inye ara ara ma obu kwusi inye umu ara.

Mpempe mwepụta

Mbadamba ihe eji etinye fim, 5 mg, 10 mg, 20 mg, 40 mg. 10 ma ọ bụ mbadamba 30. na ngwugwu mpempe akwụkwọ. 30 mbadamba na karama polymer ma ọ bụ n'ime karama polymer. Iberibe ite ọ bụla na mbadamba 10, 3, 6. ma ọ bụ mbadamba 1, 2 nke mbadamba 30. enịm ke kaadiboodu igbe.