Kedu ihe dị iche na atorvastatin na rosuvastatin?

Cholesterol dị elu na-akpata ọtụtụ ọrịa nke obi, ụbụrụ, arịa ụbụrụ. Atherosclerosis (idebe cholesterol na mgbidi nke akwara) bụ ihe kachasị akpata ọnwụ na ụwa na mba ndị bụbu Soviet Union. Statins bụ ọgwụ ndị nwere ike igbochi, yana iji ogologo oge, kwụsị mmepe nke atherosclerosis. Ntụnyere nke Atorvastatin na Rosuvastatin, dịka ndị nnọchite abụọ kachasị mma nke otu a, ga-enye gị ohere ịhọrọ ọgwụ maka nke ọ bụla.

Atorvastatin na rosuvastatin nwere otu ihe eji arụ ọrụ.

Usoro nke ime ihe

Mkpụrụ ọgwụ abụọ ahụ bụ ndị nnọchi anya otu ọgwụ ọgwụ, ya mere usoro ọrụ ha si yie. Ọdịiche dị n’etiti ha dị n’ike nke ime ihe: iji rụpụta otu ụdị nsogbu ọgwụgwọ, ọgwụ Rosuvastatin nwere ike ịbụ ọkara nke Atorvastatin.

Uzo a gha eme bu ogwu i bu ime ka enzyme di n’ime ogu nke cholesterol. N'ihi nke a, a na -ebelata ọkwa nke cholesterol dị ala na obere lipoproteins dị ala (LDL, VLDL). Ha bụ ihe kpatara ihiwe ite n’ime arịa ọbara, nkụchi obi, ọrịa strok, wdg.

E kwesịrị iji ọgwụ abụọ a mee ihe ndị a:

• Oke cholesterol zuru oke,
• Ntọala dị elu nke LDL, VLDL, triglycerides,
• Ọria obi na akwara obi (obara ezughi oke ike obi) ya na ngosipụta ya niile (nkụchi obi, angina pectoris),
• Atherosclerosis nke aorta, arịa nke ala akụkụ ala, ụbụrụ, akwara akwara,
• Site n'ọbara mgbali elu - iji gbochie mmepe nke atherosclerosis.

Ihe ngbanwe

Agaghị eji Atorvastatin mee ihe maka:

• Enwe mmachi megide ọgwụ,
• Ọrịa imeju na-arịa ya,
• Ọrụ imeju na-arụ ọrụ,
• Ime na lactation.

• Enwe mmachi megide ọgwụ,
• Ọrịa imeju na-arịa ya,
• Ọrụ imeju na-arụ ọrụ,
• Nsogbu akwara na-enweghị nsogbu,
• Ọkpụkpụ ọkpụkpụ akwara nke mebiri emebi,
• Iwere cyclosporine,
• Ime na lactation
• Afọ n’afọ iri na asatọ.

Nsonaazụ

Atorvastatin nwere ike ibute:

• Isi ọwụwa
• Adịghị Ike
• Insom
• Obi mgbu
• Ọrụ imeju na-arụ ọrụ,
• Ahụhụ nke akụkụ ENT,
• Iwe na-ewe iwe,
• Akwara na mgbu nkwonkwo
• Uwe
• Mmeghachi omume nfụkasị ahụ.

Mmetụta dị iche iche nke rosuvastatin:

• Mmepe nke ọrịa shuga mellitus (ike carbohydrate metabolism),
• Mgbu n’isi
• Iwe na-ewe iwe,
• Ọrụ imeju na-arụ ọrụ,
• Akwara mgbu
• Adịghị Ike.

Wepụta ụdị na ọnụahịa

Ọnụahịa nke mbadamba nkume Atorvastatin dịgasị iche iche dabere na onye nrụpụta:

• 10 mg, 30 pcs. - 130 - 260 p,
• 10 mg, 60 pcs. - 300 r
• 10 mg, 90 pcs. - 550 - 710 r,
• 20 mg, 30 pcs. - 165 - 420 r,
• 20 mg, 90 PC. - 780 - 1030 r,
• 40 mg, 30 PC. - 295 - 630 p.

Ofgwọ mbadamba rosuvastatin dịkwa iche iche:

• 5 mg, 28 PC. - 1970 p,
• 5 mg, 30 pcs. - 190 - 530 r,
• 5 mg, 90 PC. - 775 - 1020 r,
• 5 mg, 98 pcs. - 5620 r,
• 10 mg, 28 PC. - 420 - 1550 r,
• 10 mg, 30 pcs. - 310 - 650 p,
• 10 mg, 60 pcs. - 620 r
• 10 mg, 90 pcs. - 790 - 1480 r,
• 10 mg, 98 pcs. - 4400 r,
• 10 mg, 126 PC. - 5360 r,
• 15 mg, 30 pcs. - 600 r
• 15 mg, 90 PC. - 1320 r,
• 20 mg, 28 PC. - 505 - 4050 r,
• 20 mg, 30 pcs. - 400 - 920 p,
• 20 mg, 60 pcs. - 270 - 740 r,
• 20 mg, 90 PC. - 910 - 2170 r,
• 40 mg, 28 PC. - 5880 r,
• 40 mg, 30 PC. - 745 - 1670 r,
• 40 mg, 90 PC. - 2410 - 2880 p.

Rosuvastatin ma ọ bụ Atorvastatin - nke ka mma?

Ọ bụrụ n ’ịhọrọ ọgwụ dị mma n’ ọfụma etu esi ele ihe anya, ọ ga-abụ Rosuvastatin. Ebe obu na enwere ike iwere ya na obere usoro onodu ogwu, onu ogugu na ihe ogba n’iru ya erughi nke Atorvastatin. Agbanyeghị, ọ dị oke ọnụ, nke ụlọ ọrụ Teva ma ọ bụ Astrazenek (Krestor) mepụtara. Were ọgwụ kwa ọnwa, nke ga-ewe oke oke ọnụ maka ụfọdụ ndị ọrịa karịrị akarị. N'akụkụ a, atorvastatin ka bụ statin na-ejikarị.

Kedu nke ka mma: atorvastatin ma ọ bụ rosuvastatin? Nyocha

• Enwere m cholesterol dị elu, nna m nwụrụ n'ihi nkụchi obi n'ihe fọrọ obere ka ọ bụrụ afọ 40. Anụrụ m mmanya Atorvastatin ogologo oge, ọ fọrọ obere ka m ruo afọ 40, agaghị m anwụ ma, arịa ndị ahụ adịchabeghị mma, mana anabatacha ihe
• Enweghị m ike ị drinkụ ọgwụ a - ozugbo imeju malitere imi, adịghị ike na-apụta,
• Ogwu di iche di omimi. Achọpụtaghị mmetụta nke ya, mana ndị dọkịta niile na-amanye ya ka ọ were. Ma ule ndị ahụ dị mma mgbe ọ nwụsịrị.

• Enweghị m ike na-emefu ego ahụ kwa ọnwa n'agbanyeghị na ọ masịrị m. Enweghị m ike iguzo Atorvastatin,
• Nnukwu ndochi maka atorvastatin: usoro onunu ogwu di obere, na-anabata nke oma,
• Aghọtaghị m ihe kpatara ị ga-eji kwụọ ụdị ego a na-enweghị isi ma ọ bụrụ na ịnwere ike ị drinkụ analogues dị ọnụ ala.

Gịnị bụ statins?

Statins gụnyere otu nnukwu ọgwụ ọgwụ eji eme ka mbelata LDL na VLDL n'ime ọbara.

N'ime usoro ọgwụgwọ ọhụụ, a pụghị ịnye ihe ọkpụkpụ maka igbochi na ọgwụgwọ nke atherosclerosis, hypercholisterinemia (agwakọta ma ọ bụ homozygous), yana ọrịa obi.

Na mkpokọta, ọgwụ ndị otu a nwere otu ụdị ọgwụgwọ ahụ, i.e. obere LDL na ọkwa VLDL. Agbanyeghị, n'ihi ọtụtụ ihe dị iche iche na-arụ ọrụ na nke inyeaka, enwere ụfọdụ ọdịiche nke ekwesịrị iburu n'uche iji zere mmeghachi omume na-adịghị mma.

A na-ekekarị Statins na nke m (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) na ọgbọ IV (Pitavastatin, Rosuvastatin).

Statins nwere ike ịbụ nke sitere n'okike na sịntetik. Maka onye ọkachamara, nhọrọ nke obere, nke ọkara, ma ọ bụ ọgwụ dị elu maka onye ọrịa bụ isi okwu dị mkpa.

Rosuvastatin na Atorvastatin na-ejikarị belata kọlestrọl. Ọgwụ ọ bụla nwere atụmatụ:

Rosuvastatin na-ezo aka na akpụ nke ọgbọ nke anọ. Onye na-eme ka mmanụ dị nfe na-agwakọta n'ụzọ zuru oke na usoro onunu eji arụ ọrụ. A na-emepụta ya n'okpuru akara ụghalaahịa dị iche iche, dịka ọmụmaatụ, Krestor, Mertenil, Rosucard, Rosart, wdg.

Atorvastatin bụ nke usoro ọgbọ III. Dị ka analog ya, ọ nwere usoro sitere na ya, mana enwere oke nke ihe na-arụ ọrụ.

Enwere ụdị okwu ọgwụ a dịka Atoris, Liprimar, Toovacard, Vazator, wdg.

Ihe ndị mejupụtara ọgwụ ahụ

Mkpụrụ ọgwụ abụọ a dị n'ụdị mbadamba. A na-emepụta Rosuvastatin n'ọtụtụ usoro ọgwụ - 5, 10 na 20 mg nke otu ihe mejupụtara. Atorvastatin eweputara n’usoro ogwu nke 10,20,40 na 80 mg nke ihe eji eme ihe. N'okpuru ebe a bụ okpokoro atụnyere ihe inyeaka nke ndị nnọchite anya ama ama abụọ nke statins.

Isi ihe dị iche na Rosuvastatin na Atorvastatin bụ ngwongwo physicochemical ha. Uru rosuvastatin bụ na ọ na-agbaji ngwa ngwa na ọbara ọbara na mmiri ndị ọzọ, i.e. bụ hydrophilic. Atorvastatin nwere njirimara ọzọ: ọ na-abụ abụba na abụba, i.e. bụ lipophilic.

Site na njikwa ndị a, nsonaazụ Rosuvastatin bụ nke a na-edugoro na sel nke imeju parenchyma, na Atorvastatin - n'ụdị ụbụrụ.

Pharmacokinetics na pharmacodynamics - iche

Atnara mbadamba mbadamba mbadamba, enwere ihe dị iche iche ha nwere. Yabụ, iji rosuvastatin anaghị adabere n'oge ụbọchị ma ọ bụ nri. Ekwesighi iri nri Atorvastatin n'out oge, dika nke a na-emetụta n'ụzọ dị mma maka nnabata nke ihe nọ n'ọrụ. A na-enweta ọdịnaya kachasị elu nke Atorvastatin mgbe awa 1-2 gachara, na Rosuvastatin - mgbe awa ise gachara.

Ihe ozo di iche n'etiti statins bu metabolism ha. N'ime ahụ mmadụ, Atorvastatin na-agbanwegharị na-adịghị arụ ọrụ site na iji enzymes imeju. Yabụ, ọrụ ọgwụ a metụtara ọrụ imeju na-arụ ọrụ.

Ọ na-emetụta ya ọgwụ ndị a na-eji Atorvastatin eme n'otu oge. Ihe analog ya, nke ozo, n'ihi uzo onodu ogwu di ala, ihe fọrọ nke nta ka ọ ghara ị drugsụ ọgwụ ndị ọzọ. Ọ bụ ezie na nke a anaghị azọpụta ya ka ọnụnọ nke mmeghachi omume ọjọọ.

Atorvastatin bụ ihe kachasị nke nwere bile.

N’adịghị ka ọtụtụ akpụ, Rosuvastatin na-abụkarị metabolized na imeju: karịa 90% nke ihe a na-ewepụ na-agbanweghi na eriri afọ na naanị 5-10% site na akụrụ.

Ike na Mkpebi Ahịa

Ọrụ bụ isi nke ọgwụ steatin bụ iji belata mkpokọta LDL n'ọbara ma mee ka ọkwa nke HDL dị elu.

Ya mere, ịhọrọ n’etiti Atorvastatin na Rosuvastatin, anyị ga-atụnyere etu esi wedata cholesterol dị ala.

Otu nnyocha sayensị gosipụtara n'oge gara aga egosila na rosuvastatin bụ ọgwụ ka dị irè.

Nsonaazụ nnwale nke ogwu na-egosi n'okpuru

1. Site na iji usoro ọgwụ nhata, Rosuvastatin belata LDL cholesterol site na 10% karịa nke ọma karịa analog ya. Uru a na-enye ohere iji ọgwụ eme ihe maka ndị ọrịa nwere hypercholesterolemia siri ike.
2. Ugboro nke mmepe nke ọrịa obi na mmalite nke ihe na-egbu egbu dị elu na Atorvastatin.
3. Ọnọdụ nke mmeghachi omume ọjọọ bụ otu maka ọgwụ abụọ ahụ.

Tụnyere uru ịbelata mkpokọta cholesterol “ọjọọ” na-egosi eziokwu na Rosuvastatin bụ ọgwụ ka dị irè. Agbanyeghị, mmadụ ekwesịghị ichefu banyere ihe ndị dị ka ọnụnọ nke contraindications, mmetụta dị iche iche na ọnụ ahịa. E gosipụtara ntụle nke ọgwụ ọgwụ abụọ ahụ na tebụl.

Ya mere, atorvastatin bụ analogue dị ọnụ ala nke ndị na-enweghị ego nwere ike ị nweta.

Nke ahụ bụ ihe ndị ọrịa chere banyere ọgwụ - Rosuvastatin na-anabata nke ọma na enweghị nsogbu. Mgbe ewere ya, cholesterol na-ebelata

Comparisontụle ọgwụ na-enyere aka kwubie na n'oge a nke mmepe nke ọgwụ, ọnọdụ mbụ n'etiti mbadamba cholesterol kacha mma bụ nke ụmụ nke anọ, gụnyere Rosuvastatin.

Banyere ọgwụ Rosuvastatin na analogues ya na vidiyo a kọwara.