Nsonaazụ nke iji Captopril-AKOS na ọrịa shuga

Captopril-AKOS: ntuziaka maka ojiji na nyocha

Aha Latin: Captopril-AKOS

Koodu ATX: C09AA01

Ngwakọta ọrụ: captopril (Captopril)

Onye na-emepụta: Synthesis, Open Society (Russia)

Nkọwa na nwelite: 11/30/2018

Ego dị n'ụlọ ahịa ọgwụ: site na 10 rubles.

Captopril-AKOS bụ onye na - egbochi ọgwụ enzyme (ACE) na inhibitor, ọgwụ na - egbochi ọgwụ mgbochi.

Mwepụta wepụtara ya na ihe mejupụtara

Ọgwụ dị n'ụdị mbadamba mbadamba: flat-cylindrical, nwere chamfer, ihe fọrọ nke nta ka ọ bụrụ ọcha ma ọ bụ na-acha ọcha, nwere isi njirimara, a na-anabata marbling ọkụ, a na-etinye ihe ize ndụ nkewa na mbadamba mbadamba 50 mg (onunu ogwu nke 25 mg: 10 ma ọ bụ 25 PC.) , na ngwungwu nke 1, 2, 3 ma ọ bụ 4 ngwugwu, usoro onunu ogwu nke 50 mg: 10 ma ọ bụ pcs 20 n'ime blisters, na ngwungwu nke 1, 2, 3, 4 ma ọ bụ 5 ngwugwu, 10, 20, 30, 40 , Pọtụ 50, 60, 80 ma ọ bụ 100. N'ime ite plastik, na mkpọ kaadi nke mbụ 1, mkpọ nke ọ bụla nwekwara ntuziaka banyere iji captopril-ICCO).

Otu mbadamba 1 nwere:

ihe na-arụ ọrụ: captopril (na usoro nke akọrọ dị arọ) - 25 ma ọ bụ 50 mg,
ihe inyeaka: usoro onunu ogwu 25 mg - ọka ọka, shuga mmiri ara ehi, magnesium stearate, talc, onunu ogwu 50 mg - lactose monohydrate (shuga mmiri ara ehi), colloidal silicon dioxide (aerosil), microcrystalline cellulose, crospovidone (CL-M collidone, CL collidone), magnesium stearate, talc.

Mlọ ọgwụ

Captopril-AKOS bụ ọgwụ antihypertensive, usoro a na-arụ ọrụ bụ nke na-esite na njirimara nke ihe arụ ọrụ - captopril. Captopril bụ ihe mgbochi ACE nke mbụ nwere mgbochi SH nwere otu (sulfhydryl otu). Site na igbochi ACE, ọ na-ebelata ntụgharị nke angiotensin nke m na angiotensin nke II ma kpochapụ mmetụta vasoconstrictor na arịa venous na art art. Mbelata ogo angiotensin nke II na-akwalite mmụba nke abụọ na ọrụ nke plasma ọbara, na-eme ka mbelata ihe nzuzo nke aldosterone site na kendọm adrenal. Nke a na-eduga na mbelata ngwe ike na -akpata ihe gbasara akwara (OPSS) na mgbali ọbara (BP), nguzogide n’arụ akwara, na mbelata ihe na - ebido n’obi. Mmeputa obi uto, mmega ahụ.

N'okpuru nduzi nke isi akwara, akwara na-agbasa ruo n'ike karịa akwara. Ọzọkwa, iwere Captopril-AKOS na-eduga n'ịbawanye njikọta nke prostaglandin yana mbelata mbibi nke bradykinin.

Mmetụta antihypertensive nke captopril anaghị adabere na ọrụ nke plasma renin. Nsonaazụ ya na sistemụ anụ ahụ renin-angiotensin-aldosterone (RAAS) na-ebute mbelata ọbara mgbali n’oge ọrụ ahụ na-ebelata.

Captopril na - akwalite ọbara ọgbụgba na akwara gbasara ọbara, na - eme ka ịmịnye ọbara bechemic myocardium. Ogologo oge eji ya na-ebute mbelata ogo ọbara myocardial na mgbidi nke resistive arteries, na-egbochi ọganiru nke nkụchi obi, ma na - egbochi mmepe ọgbụgba ventricular ekpe.

Inweta Captopril-AKOS na-eduga n'ịbelata nchịkọta platelet, na nkụda obi - iji belata ọdịnaya nke sodium ion.

Mbelata tonus nke efferent arterioles nke glomeruli nke akụrụ na-enyere aka ime ka akụrụngwa intracubule na-egbochi ọdịdị nke nephropathy mamịrị.

N'ime usoro ọgwụ kwa ụbọchị nke 50 mg, captopril na-egosipụta ihe ngosipụta nke angioprotective megide arịa ọbara nke microvasculature. N'ime ndị ọrịa nwere ọrịa nephroangiopathy nke ọrịa mamịrị, ọ na-eme ka ọ daa mba na ọdịda nke ọdịda akwara dị ala.

N'adịghị ka ndị vasodilaịnụ na-ahụkarị, dị ka hydralazine na minoxidil, mbelata ọbara mgbali mgbe ị na-ewere Captopril-AKOS na-enweghị mgbakwunye tachycardia ma na-enyere aka belata ihe oxygen chọrọ. Ezigbo usoro onyunyo nke ndị ọrịa nwere nkụda obi anaghị emetụta ọbara mgbali.

Mgbe nchịkwa ọnụ gasịrị, mbelata ọbara mgbali elu kachasị na awa 1-2.5. Ogologo oge nke mmetụta hypotensive na-adabere na ọgwụ a na-enweta ya, ọ na-eru ogo kachasị mma mgbe ọtụtụ izu ọgwụ gasịrị.

Cannweghị ike ịkagbu captopril na mberede, nke a nwere ike ibute oke mmụba ọbara ọgbụgba.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, mmịpụta ọ bụla dị ihe dị ka 75% nke Captopril-AKOS weere. Nri oriri na-emekọkwa ọnụ, na -ebelata nnabata nke isi nri site na 30-40%. N'ime ụzọ izizi gafere site na imeju, 35-40% nke ihe na-arụ ọrụ bụ ihe emere. Oke ịta (C_max) n'ime plasma ọbara na-enweta n'ime elekere 0.5-1.5 ma ọ bụ 114 ng / ml.

B dabata na protein plasma ọbara - 25-30% (ọkachasị na albumin).

Ọ na - emeri ụbụrụ ọbara na ihe mgbochi placental na obere ego (erughị 1%). Na mmiri ara ara, ihe ruru 0.002% nke ọgwụ a isụrụ ka zoro ezo.

Captopril bụ metabolized na imeju ya na nguzobe nke ọgwụ na-adịghị arụ ọrụ na-arụ ọrụ ọgwụ - captopril disulfide dimer na captopril-cysteine sulfide.

Ọkara ndụ (T_1/2) captopril bụ ihe dịka awa 2-3. Ihe dị ka 95% nke ọgwụ a nabatara na-apịpụta n’akụrụ akụrụ n’ime awa iri abụọ na anọ izizi (gụnyere 40-50% na-agbanweghi).

Na ọdịda akụrụngwa na-adịghị ala ala, ọgwụ na-agbakọ, T_1/2 nwere ike ịdị site na 3.5 ruo awa 32. Ndị ọrịa nwere ọrụ mgbazinye nsogbu kwesịrị belata otu ọgwụ na / ma ọ bụ nwekwuo etiti oge a na-akwụ ụgwọ maka Captopril-AKOS.

Ihe ngosi maka ojiji

ọbara mgbali ọbara (gụnyere ọbara mgbali ọria),
ọrịa obi na - adịghị ala ala - dị ka akụkụ nke usoro ọgwụgwọ mgbagwoju anya,
dysfunction nke aka ekpe ventricle mgbe myocardial infarction na ndị ọrịa nọ n'ọnọdụ ọnọdụ nọ n'ụlọ ọgwụ,
ọrịa shuga (ọrịa mamịrị) na-arịa ụdị ọrịa shuga mellitus 1 (albuminuria karịa 30 mg / ụbọchị).

Ihe ngbanwe

nnukwu nsogbu gbasara akụrụ, nsogbu akwara gbasara akwara, stenosis, akwara na-enwe nsogbu, hyperkalemia, hyperaldosteronism, ọnọdụ mgbe akụrụ,
nnukwu ọrịa imeju,
nke aliskiren na ndị ọrụ nwere aliskiren nwere ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa mellitus ma ọ bụ ndị ọrịa nwere ọrụ mgbazinye na ikike nwebisiin creatinine (CC) erughị 60 ml / min,
lactose anagide ume, glucose-galactose malabsorption syndrome ma ọ bụ ụkọ lactase,
oge ime
inye ara
afọ ruo afọ 18
hereditary na / ma ọ bụ idiopathic angioedema megide usoro mmalite ọgwụgwọ gara aga yana ndị na - egbochi ACE (gụnyere akụkọ ihe mere eme),
hypersensitivity na ndị ọzọ ACE inhibitors, gụnyere akụkọ ihe mere eme
mmadụ inabata ya na ọgwụ ndị ahụ.

N’eji nlezianya mee, ekwesịrị ịdebe mbadamba ụrọ Captopril-AKOS maka ọrịa hypertrophic obstructive cardiomyopathy, ọrịa obi na-efe efe, mitral stenosis, aortic stenosis na mgbanwe ndị yiri ya na-egbochi mmụba ọbara site na mkpịsị aka ekpe nke obi, bụrụ na ọbara ọgbụgba na-adịghị ala ala, ụkwara akwara na-adịghị ala ala, sistem lupus ma ọ bụ etrymat. ọrịa ụbụrụ, mgbochi nke ụmị ọkpụkpụ, ọrịa ụbụrụ, ọrịa shuga, hyperkalemia, isi ọrụ imeju, mgbochi nri nke sodium chloride, hemodialysis, afọ ọsịsa, ọgbụgbọ, ma ọ bụ ọnọdụ ndị ọzọ na-eme ka mbelata ọbara na-ekesa n'oge ịwa ahụ ma ọ bụ ọrịa izugbe, hemodialysis na-eji membranes dị elu (gụnyere AN69 polyacrylonitrile membranes elu-elu), concomitant desensitizing ọgwụ, apheresis nke lipoproteins dị ala (LDL) dị ala, yana mgbakwunye na-enye mkpụrụ ọgwụ potassium, mkpụrụ nke potassium, nọchiri ndị nwere ihe na-enye potassium. na nnu, nkwadebe lithium, ndị ọrịa nke agbụrụ Negroid, na nká.

Nsonaazụ

A na - ekewa nsogbu ndị na - adịghị mma n'akụkụ nke sistem na akụkụ ahụ (dịka ugboro ole mmepe ha si dị: ọtụtụ mgbe - ≥ 1/10, ọtụtụ mgbe - /1 1/100 na 9 kwa 1 lita na - eduzi ule ọbara n'ozuzu, n'okpuru 1 x 10 9 kwa 1 liter - ọgwụ ahụ Bụrụ na ihe ịrịba ama nke ọrịa na-efe efe, gụnyere akpịrị mgbu ma ọ bụ ahụ ọkụ, a chọrọ nnwale ọbara nyocha nke ọnụ ọgụgụ leukocyte.

Okwesiri iburu n’uche na iwere Captopril-AKOS megide onodu azumahia nke hymenoptera venom na ihe ndi di otu a na –eme ka nsogbu nke anaphylactoid ghari.

N'ihe banyere mmụba nke ọrịa hepatic transaminases ma ọ bụ nrịba ama nke ọrịa jaundice, a ga-akwụsị ịgwọ ya na captopril ozugbo.

N’ebe ndị agbụrụ Negroid nọ, ndị na-egbochi ACE, gụnyere Captopril-AKOS, na-egosipụta mmetụta antihypertensive na-anaghị akpọkarị.

Nnyocha mmamịrị maka acetone na ndị ọrịa na-a theụ ọgwụ nwere ike ịrụpụta nsonaazụ dị mma.

Ime na lactation

Ojiji nke Captopril-AKOS bụ contraindicated n'oge mmegharị ahụ na inye ara.

Womenmụ nwanyị dị ime afọ na-amụ nwa na-eme atụmatụ ịtụrụ ime kwesịrị izere iji ihe ndị ACE inhibitors (gụnyere captopril). Ha kwesịrị ịkwado usoro ọgwụgwọ ọzọ.

Ọ bụrụ na ncheta mere n’oge nchịkwa nke Captopril-AKOS, a ga-achọ ka akagbuo ya ozugbo ma chọọ oge nwa ebu n'afọ na-achọ. Ojiji ovu onwa n’ime onwa mbu n’enwe ike ime ka nsogbu nke imu nwa buru n’uka nwa ebu n’afọ. Ogologo oge iji ọgwụ ahụ na II na III trimesters bụ ihe nsị nye nwa ebu n'afọ ma na-eduga na igbu oge na ossification nke ọkpụkpụ nke okpokoro isi, mbelata ọrụ gbasara akụrụngwa, oligohydramnios, a na-atụ aro ka elelee ọnọdụ nke ọkpụkpụ okpokoro isi na ọrụ akụrụ nke nwa ebu n'afọ site na ultrasound (ultrasound).

N'ime ụmụ amụrụ ọhụrụ, ndị nne ha na-anata isi akwara ogologo oge nke afọ II na III nke afọ ime, mmepe nke akwara amụ nwa, hyperkalemia, hypotension ga-ekwe omume.

Na arụ ọrụ ezumike ọrụ

Ojiji Captopril-AKOS maka ọgwụgwọ nke ndị ọrịa nwere nnukwu nsogbu akụrụ dị ka ọgbụgba akụrụ akwara stenosis, otu akụrụ stenosis nwere azotemia na-aga n’ihu, hyperkalemia refract, isi hyperaldosteronism, na ọnọdụ mgbe akụrụ akụrụ agbagha.

N'iji nlezianya mee, ekwesịrị ịnye ndị ọrịa nwere nsogbu gbasara akụrụ na-emegiri ihe nkpuchi anya.

Site na ogo obere ọrụ ọrụ mkpado na-arụ ọrụ (CC 30 ml / min ma karịa), enwere ike ịkọwa Captopril-AKOS kwa ụbọchị nke 75-100 mg.

Site na nsogbu nwere akụrụkasị siri ike (CC na-erughị 30 ml / min), usoro mbụ kwa ụbọchị ekwesịghị gafere 12.5 mg. Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye dose ahụ, na-achọpụta oge zuru oke oge, mana ndozi kwesịrị ịbụ ihe na-erughị usoro a na-eji na-agwọ ọbara mgbali elu.

Ikekwe ebumnuche ndị ọzọ nke "loop" diuretics, mana ọbụghị mkpụrụ nke usoro thiazide.

Ekwesịrị imeghari usoro usoro onunu ogwu ọ bụrụ na arụ ọrụ ezumike ọrụ na-eme ihe na-eburu n'uche ihe ngosi QC onye ọrịa na usoro a:

CC 40 ml / min: nha mbụ ị na-eme kwa ụbọchị bụ 25-50 mg, ọgwụ kachasị ụbọchị bụ 150 mg,
KK 21-40 ml / min: ihe mbụ ị na-eme kwa ụbọchị bụ 25 mg, ọgwụ kachasị ụbọchị bụ 100 mg,
KK 10-20 ml / min: nha mbụ ị na-eme kwa ụbọchị bụ 12.5 mg, otu kachasị kwa ụbọchị bụ 75 mg,
QC erughị 10 ml / min: nha mbụ ị na-eme kwa ụbọchị bụ 6.25 mg, dose kachasị elu kwa ụbọchị bụ 37.5 mg.

Jiri na agadi

Ekwesịrị ịkpachara anya na captopril-AKOS n’ebe ndị ọrịa agadi nọ.

Ọgwụ izizi maka ndị ọrịa agadi bụ 6.25 mg 2 ugboro n'ụbọchị. Usoro usoro insing a na-egbochi ịrụ ọrụ na-arụ ọrụ nke ukwuu, yabụ, a na-ahụta ya maka ezigbo mmezi. A na-atụ aro idozi ọnụọgụ nke Captopril-AKOS na-eburu n'uche usoro ọgwụgwọ onye ọrịa oge niile, na-ejigide ya na ọkwa kachasị dị ala.

Mkparịta ụka ọgwụ ọjọọ

antagonensin II angagonensin II antagonists (ARA II), aliskiren na ọgwụ ndị ọzọ na-emetụta RAAS: mụbaa ihe ọghọm nke mbelata ọbara mgbali elu, arụ ọrụ ezumike n’akuku (gụnyere ọdịda akụrụ oke), hyperkalemia. N'akụkụ a, ọ bụrụ na ọ dị mkpa, nhọpụta ọgwụ ndị ọzọ na-emetụta RAAS kwesịrị iji nlezianya nyochaa ọbara mgbali, ndị na-egosi ọrụ akụrụ, plasma electrolytes. Site na ezigbo arụ ọrụ na-arụ ọrụ yana ụdị ọrịa shuga 2 nke ọrịa mellitus, a ga-ezere ijikọ ya na aliskiren,
potassium-sparing diuretics (amiloride, triamteren, spironolactone, eplerenone), nkwadebe potassium, mgbakwunye potassium, ihe nnọchianya nnu: mụbaa ihe ize ndụ nke hyperkalemia, ọ dị mkpa iji chịkwaa ọdịnaya plasma potassium,
diuretics (thiazide na "loop"): n'ọtụtụ ọnụọgụgụ na-abawanye ohere nke hypotension akwara,
diuretics, izu ike nke akwara, aldesleukin, alprostadil, cardiotonic, alfa₁-blockers, beta-igbochi, alfa n’etiti₂-adrenomimetics, ngwa mgbochi calcium na-egbochi, nitrates, minoxidil, vasodilators: na -eme ka mmetụta hypotensive nke Captopril-AKOS,
ọgwụ ịrahụ ụra, ọgwụ ọgwụ, anxiolytics, antidepressants: welie mmetụta antihypertensive nke captopril,
ọgwụ mgbochi na - abụghị steroidal anti-inflammatory (NSAIDs), gụnyere indomethacin, ndị na - ahọrọ cyclooxygenase-2 inhibitors, estrogens: site na iji ogologo oge, ha na - ebelata ịdị irè nke captopril. Na mgbakwunye, ngwakọta nke NSAIDs na ndị na-egbochi ACE nwere ike inwe mmetụta dị ukwuu na ịbawanye mkpokọta nke serum potassium megide ndabere nke ngbanye n'otu oge na arụmọrụ gbasara akụrụ (gụnyere nnukwu gbasara akụrụ), ọkachasị na ndị ọrịa nwere akụkọ banyere ọrụ ezumike mkpirikpi, ndị ọrịa agadi, ma ọ bụ iwetulata nke na-ekesa ọbara. ,
ogwugwo izugbe: mbelata ọbara mgbali elu n’oge ana - arụ ọrụ, enwere ike ọfụma, ọkachasị ma ọ bụrụ na ọgwụ izizi ọ bụla nwere mmetụta antihypertensive,
Nkwado lithium: ikuku lithium na-agbadata ma tinye uche ya na ọbara,
allopurinol, procainamide: ịbawanye ụba nke neutropenia na / ma ọ bụ Stevens-Johnson syndrome,
glucocorticosteroids, epoetin, estrogens na ọgwụ mgbochi ọnụ, naloxone, carbenoxolone: na-ebelata ọrụ nke Captopril-AKOS,
nhazi ọla edo: nlekọta ivodi nke sodium aurothiomalate nwere ike ibute mgbawara na onye ọrịa, gụnyere mbelata ọbara mgbali, ihu ihu, ọgbụgbọ, ọgbụgbọ,
ọrịa ọmịiko: nwere ike belata nsonaazụ na-arụ ọrụ nke captopril,
ndị na-ahụ maka hypoglycemic nke nchịkwa ọnụ, insulin: mụbaa ihe ize ndụ nke hypoglycemia,
antacids: belata nnabata nke captopril n'ime eriri afọ,
ethanol: na - akwalite mmetụta hypotensive nke Captopril-AKOS,
probenecid: na - enyere aka belata mkpochapụ mkpocha mkpịsị nke captopril, nke na - eduga na mmụba nke mkpo ya na ọbara,
azathioprine, cyclophosphamide: mụbaa ohere nke ịmalite nsogbu ọgbụgba,
propranolol: bioavailability ya na-abawanye,
cimetidine: na - enyere aka iwelie ịta nke ihe dị n'ọrụ na plasma ọbara,
clonidine: belata ogo mmetụta antihypertensive.

Ihe analogues nke Captopril-AKOS bu: Captopril, Captopril-Ferein, Captopril-FPO, Captopril-UBF, Captopril Velfarm, Kapoten, Katopil, Epsitron, Alkadil, Angiopril-25, Blockordil, Vero-Captopril, Captopril-STI na ndị ọzọ.

Usoro nke ime ihe

Ihe eserese dị n'okpuru na-egosi mmetụta nke onye na - egbochi ACE na usoro ntụgharị ihe abụọ:

Imeghari otu usoro nke anakpo angiotensin II, mbelata nke ịbara ya n’ime ọbara.
Mmebi nke mbibi bradykinin na ogige na-anọpụ iche, nke pụtara inye aka na nchịkọta ya

Usoro nke mmetụta nke onye na - egbochi ACE na usoro ntụgharị ihe abụọ

Na nzaghachi na mbelata ọbara ọgbụgba ma ọ bụ ọnọdụ na - akpata nrụgide, renin peptide amalitere ịhapụ akụrụ ya akụrụ. Ọ na - arụ ọrụ na protein angiotensinogen ma na - agbanwe ya ka ọ bụrụ angiotensin I. N'aka nke ya, ọ bụrụ angiotensin II site na enyemaka nke angiotensin-enzyme ntụgharị. A na-akpọ sistemụ ahụ dum renin-angiotensin-aldosterone (RAAS).

Angiotensin II nwere ihe ndia:

belata akwara nke mgbidi arịa ọbara, na-ebelata lumen. Nke a na - ebute mmụba n'ọbara, na - eme ka ibu dị n'obi, na - eme ka ọbara na - ebute akwara dị n'ime ahụ,
na-abawanye ịta aldosterone. Aldosterone, n’aka nke ya, na-abawanye ụba nke mmiri n’ime ahụ. Nke a na - eduga na edema na nrụgide ndị ọzọ na sistem. Maka nke a, aldosterone dị na ụzọ akụrụ na-a sụ mmiri sodium ma na-ewepu potassium,
na - akwalite njikọta nke ngwa ọgụ dịgasị iche iche - cytokines. Ha na-emebi ma kwalite ọrịa sclerosis nke mgbidi arịa, akwara na anụ ahụ na akụrụ.

Na mgbakwunye na RAAS, ACE na-egbochi usoro kinin-kallikrein. Bradykinin bụ maka usoro abụọ:

ntụrụndụ nke arịa ọbara, i.e. wedata mgbali elu,
mkpali na mmeghachi omume nfụkasị.

Usoro onunu ogwu na nhazi

A na-eji ọnụ ekwu okwu Captopril-AKOS otu awa tupu nri. A na-edobe usoro usoro onunu ogwu ya iche iche. Mgbe ị na-etinye usoro nke captopril dị ka ihe ndị akọwapụtara si dị, ọ dị mkpa iji captopril n'ụdị usoro onunu ogwu: mbadamba 12.5 mg.

Site n'ọbara mgbali elu, ọgwụgwọ na-ebido na nke kachasị dị ala nke 12.5 mg ugboro abụọ n'ụbọchị (adịkarịghị ugboro 6.25 mg ugboro abụọ n'ụbọchị). Ekwesịrị ị paida ntị na ntinye nke akpa ọgwụ n'oge awa mbụ. Ọ bụrụ na hypotension akwara zụlitere na nke a, a ga-ebugharị onye ọrịa ahụ n'ọnọdụ kwụ ọtọ (ụdị mmeghachi omume a na ọgwụ mbụ ekwesịghị ịbụ ihe mgbochi na usoro ọgwụgwọ ọzọ). Ọ bụrụ na ọ dị mkpa, a na-eji nwayọ were dose ahụ (na etiti oge izu 2-4) wee rue mgbe akachasị rụpụta nke ọma. Site n'ọbara mgbali elu dị nwayọ ma ọ bụ na-agabigaghị ókè, oge a na-ahụkarị bụ 25 mg ugboro abụọ kwa ụbọchị, dose kachasị bụ 50 mg ugboro abụọ n'ụbọchị. Na nnukwu ọbara ọgbụgba, ọnụọgụ kachasị bụ 50 mg ugboro atọ n'ụbọchị. Oke kachasị kwa ụbọchị bụ 150 mg.

N'ime ndị ọrịa agadi, ọgwụ izizi bụ 6.25 mg ugboro abụọ kwa ụbọchị.

N’ewepu obi na-adịghị ala ala, e dekọtara ya ya na diuretics na / ma ọ bụ ya na nhazi digitalis (iji zere ịbelata ọbara mgbali elu, a na-akagbu akarị ma ọ bụ belata ọgwụ ahụ tupu nchịkwa nke Captopril-AKOS). Ọgwụ nke mbụ bụ 6.25 mg ma ọ bụ 12.5 mg ugboro atọ kwa ụbọchị, ma ọ bụrụ na ọ dị mkpa, mụbaa dose ahụ nwayọ (na oge dịkarịa ala izu abụọ) na 25 mg ugboro abụọ kwa ụbọchị. Oke kachasị kwa ụbọchị bụ 150 mg.

N'ihe banyere dysfunction nke ventricle aka ekpe mgbe ọ nwesịrị infarction myocardial n'ime ndị ọrịa nọ n'ọnọdụ akwụkwụ ọtọ, ojiji nke Captopril-AKOS nwere ike ịmalite dị ka ụbọchị 3 mgbe ọ gbasasịrị myocardial. Ọgwụ izizi bụ 6.25 mg / ụbọchị, mgbe ahụ enwere ike ịbawanye ọgwụ kwa ụbọchị gaa na 37.5-75 mg na usoro 2-3 (dabere na ndidi nke ọgwụ ahụ). Ọ bụrụ na ọ dị mkpa, a na-amụba dose ahụ ruo ogo kachasị ogologo kwa ụbọchị 150 mg / ụbọchị. Site na mmepe nke hypotension, ike ịbelata nwere ike ịchọrọ. Mgbalị ndị ọzọ ịchọrọ iji ụzọ kachasị elu nke 150 mg kwa ụbọchị kwesịrị ịdabere na nnagide ndị ọrịa nke Captopril-AKOS.

Site na nephropathy na-arịa ọrịa shuga, a na-enye ọgwụ kwa ụbọchị nke 75-100 mg / ụbọchị maka usoro 2-3. N'ihe banyere ọrịa shuga na-akpata insulin na microalbuminuria (mwepụta nke albumin 30-300 mg kwa ụbọchị), dose ahụ bụ 50 mg ugboro abụọ kwa ụbọchị. Site na mkpokọta protein karịa 500 mg kwa ụbọchị, ọgwụ ahụ na-arụ ọrụ na ọnụọgụ 25 mg ugboro atọ kwa ụbọchị.

Site n'ọkwa dị oke ala nke nsogbu akụrụngwa arụrụala (mwepụta creatinine (CC) - opekata mpe 30 ml / min / 1.73 m), enwere ike kenye Captopril-AKOS na ogo 75-100 mg / ụbọchị. Site na ogo ogosi akwara dị elu (CC - erughị 30 ml / min / 1.73 m), usoro izizi ekwesịghị ịbụ ihe karịrị 12.5 mg / ụbọchị, mgbe ahụ, ọ bụrụ na ọ dị mkpa, a na-eji nwayọọ nwayọọ na-abawanye dose of Captopril-AKOS. oge, mana na-eji obere karịa na ọgwụgwọ nke ọbara mgbali elu, ọgwụ kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, a na-edenye loop diuretics, ọ bụghị diuretics nke usoro hyazide.

Mmetụta akụkụ

N'ime ndị ọrịa agadi, ọgwụ izizi bụ 6.25 mg ugboro abụọ kwa ụbọchị.

Dodoụbiga ya ókè

Mgbaàmà: mbelata ọbara mgbali elu, ruo

ida, infarction myocardial, nnukwu ihe ọghọm cerebrovascular, nsogbu nke thromboembolic.

Ọgwụ: tinye onye ọrịa ahụ na aka ya dị ala, nke a na-eme ka iweghachi ọbara ọgbụgba (mmụba na-ekesa olu ọbara, tinyere iv infusion nke 0.9% sodium chloride solution), ọgwụgwọ Symptomatic. Ikekwe, iji usoro ọgwụgwọ a na - eme ihe na - adịghị mma.

Mmekọrịta na ọgwụ ndị ọzọ

Edebere ọgwụ ndị belata ihe ọmịiko n’arụ ndị ọrịa na-elezi anya. Ndị na-egbochi Beta na-enye ntakịrị mmetụta antihypertensive ọzọ mgbe agbakwunyere ha na capropril, mana mmetụta zuru ezu na-erughị ihe a tụrụ anya ya.

A na - eme ka mmetụta antihypertensive ghara ịdị na - egbochi ọgwụ mgbochi mkpali (NSAIDs) (egbubere Na + na ibelata prostaglandin), ọkachasị megide mmalite nke ịdịghachi ala dị ala, na estrogen (agbatị Na +) na-egbu oge. Njikọ ya na thiazide diuretics, vasodilators (minoxidil), verapamil, beta-mgbochi, tricyclic antidepressants, ethanol na-akwalite mmetụta hypotensive.

Ihe jikọtara ya na ọgwụ ndị na-enye potassium (dịka ọmụmaatụ, triamteren, spironolactone, amiloride), nkwado potassium, cyclosporine, mmiri ara ehi nwere nnu (nwere ike ịnwe K + ruo 60 mmol / l), mgbakwunye potassium, ihe nnọchi nnu (nwere nnukwu nke K +) na-abawanye. ihe egwu nke ịba hyperkalemia.

Na-eme ka mkpọtụ nke lithium na-agbada.

Site na nhọpụta nke captopril mgbe ị na-ewere allopurinol ma ọ bụ procainamide, ihe ize ndụ nke ịmalite ọrịa Stevens-Johnson syndrome na immunosuppressive ime ihe na-abawanye. Ojiji nke captopril n'ime ndị ọrịa na-ewere immunosuppressants (dịka ọmụmaatụ, azathioprine ma ọ bụ cyclophosphamide) na-abawanye n'ihe ize ndụ nke ịmalite ọrịa ọgbụgba. Ojiji nke ACE inhibitors na insulin, yana ọgwụ hypoglycemic nke ọnụ nwere ike iduga mmepe nke hypoglycemia. A na-ahụkarị ihe ize ndụ kachasị nke ịmalite hypoglycemia n'izu ndị mbụ nke ọgwụgwọ njikọta, yana ndị ọrịa nwere ọrụ mkpo. Ndị ọrịa nwere ọrịa shuga chọrọ nlezianya nyocha nke glycemia, ọkachasị mgbe ọnwa mbụ nke iji onye na-egbochi ACE nwee ọgwụgwọ.

Njirimara ngwa

Tupu ịmalite, yana kwa ụbọchị mgbe a na-ahụ ya na Captopril-AKOS, ekwesịrị inyocha ọrụ ezumike. N'ime ndị ọrịa nwere ọrịa obi na-adịghị ala ala, a na-eji ha n'okpuru nlekọta ahụike. Na agbanyeghi iji Captopril-AKOS agbago ogologo oge, ihe dika 20% nke ndi oria na-enwewanye mmachi na urea na serum creatinine site karia 20%, ma e jiri ya tuo iwu ma obu uru mbu. Ihe na-erughị 5% nke ndị ọrịa, ọkachasị ndị nwere nnukwu nephropathy, chọrọ ịkwụsị ọgwụgwọ n'ihi mmụba na itinye uche creatinine. N'ime ndị ọrịa nwere ọbara mgbali elu ya na Captopril-AKOS, a na-ahụ hypotension arterial hypotension naanị na ọnọdụ ndị a na-adịghị ahụkebe, ohere nke ịmalite ọnọdụ a na-abawanye site na ụkọ mmiri na oke nnu (dịka ọmụmaatụ, mgbe ejiri ọgwụgwọ kpụ ọkụ n'ọnụ), na ndị ọrịa nwere ọrịa obi na-adịghị ala ala ma ọ bụ na -ebe usoro akwara. . Enwere ike belata nbilata nke ọbara mgbali elu site na kagbuo mbido (ụbọchị 4-7) nke diuretic ma ọ bụ mmụba na sodium chloride oriri (ihe dị ka otu izu tupu mmalite nke nchịkwa), ma ọ bụ site na nchịkwa nke captopril na mmalite ọgwụgwọ na obere doses (6.25- 12.5 mg / ụbọchị). N'oge ọgwụgwọ na outpatient, dọọ onye ọrịa aka na ọdịdị ahụ ga-ekwe omume nke mgbaàmà nke ọrịa, na-achọ ka a na-ahụ nyocha ahụike, nyocha na ụlọ nyocha. Ke akpa ọnwa 3. Usoro ọgwụgwọ kwa ọnwa na-enyocha ọnụ ọgụgụ mkpụrụ ndụ ọbara ọcha, wee - 1 oge n'ime ọnwa 3: n'ime ndị ọrịa nwere ọrịa autoimmune na ọnwa atọ mbụ. - izu ọ bụla 2, mgbe ahụ - ọnwa abụọ. Ọ bụrụ na ọnụ ọgụgụ nke leukocytes dị ala karịa 4000 / μl, egosipụtara nnwale ọbara n'ozuzu ya, n'okpuru 1000 / ,l, a kwụsịrị ọgwụ ahụ. Ọ bụrụ na ihe mgbaàmà mbụ nke ọrịa nke abụọ malitere megide myeloid hypoplasia, a ga-eme nyocha ọbara zuru ezu ozugbo. Ọ dị mkpa wezuga ịkwụsị nnwere onwe nke ọgwụ ahụ yana nnwere onwe dị ịrịba ama na ịdị ukwuu nke mmega ahụ. N'ụfọdụ, megidere ndabere nke iji ndị mgbochi ACE, gụnyere captopril, enwere mmụba na mkpokọta potassium na ọbara ọbara. Ihe ize ndụ nke ịmalite hyperkalemia na iji ACE inhibitors na-abawanye na ndị ọrịa nwere ọdịda akụrụ na mellitus ọrịa shuga, yana ị potassiumụ ọgwụ na-egbu ọgwụ, nhazi nke potassium ma ọ bụ ọgwụ ndị ọzọ na-eme ka mmụba na mkpokọta potassium na ọbara (dịka ọmụmaatụ, heparin). Ekwesịrị izere ịme ojiji nke potassium na-eme ka oge na-aga. Mgbe ị na-eduzi usoro ịba ọcha n'anya na ndị ọrịa na-anata Captopril-AKOS, a ga-ezere ojiji nke membreses dialysis membranes (dịka ọmụmaatụ AN69), ebe ọ bụ na n'ụdị ndị dị otu a, enwere ike ịbawanye mmeghachi omume anaphylactoid. N'ihe banyere mmepe nke angioedema, a na-akagbu ọgwụ ahụ ma na-ahụ maka nlekọta ahụike yana usoro ọgwụgwọ Symptomatic. Mgbe ị na-ewere Captopril-AKOS, enwere ike ịhụ mmeghachi omume adịgboroja mgbe ị na-enyocha mmamịrị maka acetone. Ike nke ọgwụ iji metụta omume ma ọ bụ usoro arụ ọrụ nke ahụ, mmekọrịta ụtaba, mmanya, nri: n'oge ọgwụgwọ, ọ dị mkpa izere ịkwọ ụgbọala na itinye aka n'ihe omume ndị dị ize ndụ nke chọrọ ịba ụba nke nlebara anya na ọsọ nke mmeghachi omume psychomotor, n'ihi enwere ike ịmalite ịda mba, ọkachasị mgbe ị theụchara ọgwụ mbụ.

Nchedo nchekwa

Ihe akpachara anya: iji ọrịa oria autoimmune siri ike (ọkachasị sistemu lupus erythematosus ma ọ bụ scleroderma), mgbochi nke ụmị ọkpụkpụ (ọgụ nke neutropenia na agranulocytosis), ọrịa ụbụrụ, mellitus ọrịa shuga (mmerụ ahụ na-arịa hyperkalemia), na ndị ọrịa nọ n'ọrịa akụrụngwa, nri mgbochi mgbochi sodium, hyperaldosteronism nke mbụ, ọrịa obi na-efe efe, ọnọdụ ndị metụtara yana mbelata olu nke na-ekesa ọbara (gụnyere afọ ọsịsa, vomiting), na nká.

Iji nlezianya kpachara anya, a na-edenye ndị ọrịa nọ ntakịrị nnu ma ọ bụ nri nnu (ma ọ bụrụ na ha nwere ike ibute ọrịa hypotension) na hyperkalemia.

Nrụgide dị a shouldaa ka m kwesịrị iwere?

Elele dị elu karịa ọnụọgụ ọbara mgbali elu karịa 140/90 mm RT. Art. Captopril AKOS bụ ọgwụ dị mkpụmkpụ. Mmetụta ya na-ewe ihe dị ka awa 6. N'ihi ya, ọtụtụ mgbe, ndị dọkịta na-atụ aro maka nsogbu ọbara ọgbụgba, maka iji ya na-aga n'ihu na ọbara mgbali ọgwụ ka enyere ọgwụ ogologo oge.

Nwere ike ị were ọgwụ ahụ na mpụta ọbara mgbali elu akwara, mgbe mmụba nke ọbara mgbali adịghị ntakịrị ma ọ dị ụkọ, wee gwaa dọkịta gị. Mana egosighi ya na ntuziaka maka ojiji nke Captopril AKOS n'oge nrụgide kwesịrị iwere. Yabụ, ọ bụrụ na nsonaazụ nke ọgwụ a dabara na onye ọrịa na onye dibịa bekee, ị nwere ike ịhapụ usoro ọgwụgwọ a maka iji ya na-aga n'ihu.

Ntụziaka maka ojiji

Iji gbochie nsonaazụ ndị ọzọ, ha na-amalite iji obere ọgwụ. Edere ya na 6 ruo 12 mg ugboro atọ n'ụbọchị.
A na-enyocha nsonaazụ ya mgbe ụbọchị ole na ole gasịrị, ọgwụ ọgwụ ga-agbakọ n'ime ahụ.
Ọ bụrụ na usoro onunu ogwu ezughi iji nweta nsonaazụ ahụ, mgbe ahụ, a ga-eji nwayọ belata ahụ ruo ogo 25-50 mg ugboro abụọ n'ụbọchị.
Ka o kwere mee n’ụbọchị, ị nwere ike were ọgwụ ruru ọgwụ ruru ọgwụ ọgwụ ruru iri.
Na nsogbu ọbara ọgbụgba, ya bụ, mgbe ọbara mgbali rute ọnụọgụ dị elu karịa 180/110 mm RT.Art., Were 25 mg nke Captopril chere chere mbelata nrụgide maka ọkara otu awa.
Ọ bụrụ na mmetụta ahụ emeghị, ị ga - emeghachi ọgwụ ọzọ.

Ogologo oge ole ka Captopril AKOS belata nrụgide?

A na-achọta ọgwụ a n'ọbara mgbe nkeji iri na ise gasịrị, ịta kachasị nke ihe ahụ na-apụta n'ime nkeji 60-90, mgbe ahụ jiri nwayọ belata.

Captopril na-arụ ọrụ ihe dị ka awa 6, yabụ, oge nchịkwa ya bụ ugboro atọ.

Nyocha ndị ọrịa na ngwa

Nyocha banyere Katopril AKOS bụ nke kachasị mma.

Uru nke ọgwụ a gụnyere:

Mmalite ngwa ngwa
ọnụ ala
Iche obere mbadamba ụfe, adiri mfe ilo,
na - ewepu ọgbụgbọ, isi ọwụwa,
enwere ike iji ya n'ụlọ dịka enyemaka mbụ,
enwere ike iji ya maka nrụgide adịkarịsịrị na-agbago ọnọdụ.

Ihe ndị a bụ ọghọm nke ọgwụ:

ụtọ uto
obere oge
adabaghị kwa ụbọchị, iji na-adịgide adịgide.
E nwere ọgwụ ndị ka dị irè maka ịgwọ ọbara mgbali elu.

Kedu ihe dị iche na Captopril na Captopril AKOS?

Ntụziaka nke Captopril AKOS adịghị iche na nkuzi nke Captopril. Yabụ kedu ihe dị iche na Captopril na Captopril AKOS? Ihe nganiihu AKOS putara bu na ndi otu Kurgan na-emekorita ihe omuma nke ogwu na emeputa ogwu a. Companylọ ọrụ a arụ ọrụ kemgbe 1958. Osisi ahụ na-emepụta ihe karịrị 3% nke ọgwụ ọgwụ si na ahịa ọgwụ Russia. Ngwaahịa niile na-agafe njikwa mma na ọkwa niile nke mmepụta.

Mmekọrịta na ọgwụ ndị ọzọ

Ọgwụ Diuretic otu na-ebuli ịdị irè nke captopril, na-abawanye itinye uche ya na ọbara ọtụtụ oge. Enweghị A na-achọpụta mmetụta hypotensive mgbe ị na-ewere NSAID ọ bụla, karịsịa indomethacin.

Ọzọkwa, ịdị mma nke iji ọgwụ ahụ ga-ebelata ma ọ bụrụ jikọtara ya na estrogens nke artificially na n'otu oge, a na-eji clonidine eme ihe.

Ngwakọta na-adịghị mma na potassium na sodium salts na-egbu oge nke ikpe-azu na aru, ma na-akpasu egbu egbu.

A na-ahụta mmepe nke ọgbụgbọ, ọgbụgbọ na ọnwụ nke mmụọ site n'otu oge iji captopril na njikere nwere ọla edo.

A machibidoro iwu ijikọ ya na ọgwụ ndị dị ka:

Allopurinol na procainamide - na - eduga na mmepe nke Stevens-Jones syndrome, ma na - emekwa ka ihe egwu dịkwuo ike ma guzobe na neutropenia.
Insulin - okpukpu abuo nke puru ime hypoglycemia (mmụba shuga dị n'ọbara).
Cyclosporins - oliguria na - etolite, nke nsogbu ọdịda na-aga n'ihu.
Azathioprine nke immunosuppressants nke na - eduga n’usoro ọgbụgba ọbara (ọgbụgba ọbara ọbara, ahaghị n ’ala sel).

Ọ bụrụ n’ịchọrọ iji Captopril na ọgwụ ndị ọzọ n’otu oge, ị ga-agakwuru dọkịta gị oge niile banyere ọnụnọ nke mmeghachi omume ọjọọ.

Vidio: Mkpuchi Renal

N’oge ime ime

A naghị eji Captopril agwọ ọrịa na ụmụ nwanyị dị ime, n'ihi na nke a nwere ike imetụta ọnọdụ nwa ebu n'afọ n'ụzọ ọjọọ. na-ebute nsogbu obi obi. Should ga-ajụkwa ịillsụ ọgwụ n’oge a na-a breastụ ara, ebe ọ bụ na akụrụngwa nọ n'ọrụ na-abanye nke ọma n'ime mmiri ara ara ma nwee ike ibute mgbali elu nke nwa amụrụ ọhụrụ.

Usoro na ọnọdụ nchekwa

Ndụ nchekwa nke Captoril Akos bụ ọnwa 24 site na ụbọchị a rụpụtara, nke egosiri na ngwugwu ahụ. Chekwaa n’ebe kpọrọ nkụ, ọchịchịrị, na-enweghị okpomọkụ karịa 25 Celsius.

Ọnụ ego dị na ụlọ ahịa ọgwụ Russia maka Captopril Akos anaghị agafe 25 rubles kwa iko 10 mbadamba. Na Ukraine, enwere ike ịzụta ọgwụ ahụ n'otu ọnụ ala - 25 hryvnia.

N'ime ọgwụ ndị nwere ụdị antihypertensive yiri ya, anyị nwere ike ịmata:

Ọtụtụ nyocha nke ndị ọrịa na-eji Captopril Akos dị ka ọgwụ na-egosi arụmọrụ ya dị elu. Ọrịa ọ bụghị naanị arụmọrụ dị elu, kamakwa akụkụ ndị ọzọ dị mma:

ọnụahịa dị mma
anụ ahụ na-anabata ya nke ọma.
enweghị nsogbu
A na-achọpụta ịdị irè mgbe usoro izizi nke mbụ gasịrị,
enwere ike iji ya dịka akụkụ nke usoro ọgwụgwọ dị mgbagwoju anya.

Naanị n'ihe ndị dịpụrụ adịpụ bụ mmadụ ịnagide ihe a na-ekwu okwu ya n'ụdị mmeghachi ahụ nfụkasị (urticaria).

Mmechi

N'ụzọ dị otú a Captopril Akos na - ejikọ ọnụahịa dị elu na ọnụahịa ọnụ ala, na-enye gị ohere ịzụrụ ọgwụ ahụ n'ahịa ọgwụ ọ bụla. N’okpuru ndụmọdụ na ndụmọdụ dọkịta niile, ọgwụ a ekwughị mmeghachi omume ọjọọ. Na ọnụnọ nke mmeghachi omume nfụkasị, tupu mmalite nke ọgwụgwọ, nnwale ule maka omume nke mmeghachi omume ọjọọ bụ ihe iwu.

Iche-iche, aha, ihe mejupụtara na ụdị ịtọhapụ

Captopril dị ugbu a n'ọtụtụ ụdị ndị a:

Captopril
Captopril Vero
Captopril Hexal,
Captopril Sandoz,
Captopril-AKOS,
Captopril Acre
Captopril-Ros,
Captopril Sar,
Captopril-STI,
Captopril-UBF,
Captopril-Ferein,
Captopril-FPO,
Captopril Stada,
Captopril Egis.

Varietiesdị ọgwụ a dị iche na ibe ha naanị site na ọnụnọ nke mkpụrụ okwu ọzọ na aha, nke na-egosi ndebiri ma ọ bụ aha a ma ama nke ndị na-emepụta otu ụdị ọgwụ. Ma ọ bụghị ya, ụdị Captopril dịcha iche na ibe ha, ebe ọ bụ na e mepụtara ha n'otu usoro onunu ogwu, nwere otu ihe eji arụ ọrụ, wdg. Ọzọkwa, ọtụtụ mgbe ihe dị ike na Captopril iche na-abụkarị otu, ebe ọ bụ na azụrụ ya n'aka nnukwu ndị nrụpụta. China ma ọ bụ India.

Ndi iche n’ime aha Captopril iche bu n’ihi mkpa ụlọ ọrụ ọ bụla na-ede ọgwụ ga-edebanye aha ọgwụ ha na-emepụta n’okpuru aha mbụ, nke dị iche na ndị ọzọ. Ma ebe ọ bụ na n'oge gara aga, n'oge Soviet, osisi ọgwụ ndị a mepụtara otu Captopril na-eji otu teknụzụ eme ihe, ha na-agbakwunye otu okwu ọzọ na aha a ma ama, nke bụ ndebiri nke aha ụlọ ọrụ ahụ, ma, ya mere, a na-enweta aha pụrụ iche site n'ụzọ iwu kwadoro dị iche na ndị ọzọ niile.

Ya mere, enweghị ọdịiche pụtara ìhè n'etiti ụdị ọgwụ ahụ, yabụ, dịka iwu, a na-ejikọ ha n'okpuru otu aha a na-akpọ Captopril. Ọzọkwa na ederede nke ederede anyị ga-ejikwa otu aha - Captopril - gosipụta ụdị ya niile.

Varietiesdị Captopril nile dị na otu usoro onunu ogwu - nke a mbadamba onụ. Dị ka umi ọrụ Mbadamba ụrọ nwere ihe isi okwu, aha nke, nke nyere aha ọgwụ ahụ.

Topdị Captopril dị na usoro dịgasị iche iche, dịka 6.25 mg, 12.5 mg, 25 mg, 50 mg na 100 mg kwa mbadamba. Sdị dos dị iche iche na-enye gị ohere ịhọrọ nhọrọ kachasị mma maka ojiji.

Dika ihe inyeaka Capdị Captopril nwere ike ịnwe ihe dị iche iche, ebe ọ bụ na ụlọ ọrụ ọ bụla nwere ike gbanwee ihe ha mebere, na-anwa imezu ihe ngosipụta nke arụmọrụ dị mma. Ya mere, iji dokwuo anya ihe mejupụtara ọgwụ inyeaka nke ụdị ọgwụ ọ bụla akọwapụtara, ọ dị mkpa iji nlezianya mụọ mpempe akwụkwọ agbakwunye na ntuziaka.

Edekọrịtara ọnụ maka Captopril na Latin dị ka ndị a:
Rp: Tab. Captoprili 25 mg Nke 50
D.S. Were 1/2 - 2 mbadamba ugboro 3 kwa ụbọchị.

Ahịrị nke mbụ nke ndenye ọgwụ mgbe ahọpụtasịrị “Rp” na-egosi ụdị usoro onodu ogwu (n’okwu a Tab. - mbadamba), aha ọgwụ (na nke a, Captoprili) na usoro onunu ogwu ya (25 mg). Mgbe akara ngosi "Ee", ọnụ ọgụgụ mbadamba nkume nke onye na-ere ọgwụ ga-ahapụrịrị onye na-ere ọgwụ ahụ. N’ahịrị nke abụọ nke uzommeputa ahụ mgbe ahịrị okwu “D.S.” Enyere ozi maka onye ọrịa nwere ntuziaka maka otu esi a theụ ọgwụ.

Gịnị na-enyere aka na-arụ ọrụ aka (usoro ọgwụgwọ)

Captopril lowers ọbara mgbali elu ma belata ibu ahụ n’obi. N'ihi ya, a na-eji ọgwụ ahụ na ọgwụgwọ nke ọbara mgbali elu akwara, ọrịa obi (nkụda obi, infarction myocardial, myocardial dystrophy), yana nephropathy mamịrị.

Ihe dị na Captopril bụ ịkwụsị ọrụ nke enzyme, nke na-eme ka nchegharị nke angiotensin I ruo angiotensin nke abụọ, yabụ, ọgwụ ahụ bụ ndị otu nke ndị na - egbochi ACE (ndị na - eme ka enzyme angiotensin). N'ihi omume nke ọgwụ ahụ, e guzobeghị angiotensin II n'ime ahụ - ihe nwere mmetụta vasoconstrictor dị ike ma, n'ihi ya, na-eme ka ọbara mgbali elu. Mgbe angiotensin nke abụọ etoliteghị, akwara ọbara na-adịwanye ala, ma, yabụ, ọbara mgbali ahụ bụ nke dịkarịsịrị elu ma ghara ịdị elu. Site na nsonaazụ Captopril, mgbe a na-ewere ya mgbe niile, ọbara mgbali na-ebelata ma na-edebe ihe ọ bụla ịnabata. Oke nrụgide kachasị na - apụta 1 - 1.5 awa mgbe ị nwesịrị Captopril. Mana iji nweta nrụgide na-adịgide adịgide, a ghaghị ị theụ ọgwụ ahụ ma ọ dịkarịa ala ọtụtụ izu (4-6).

Ọzọkwa ọgwụ na-ebelata nrụgide n’obi, na-agbasa oghere nke arịa, n'ihi nke akwara obi chọrọ obere mgbalị iji tinye ọbara n'ime akwara na akwara. Yabụ, isi mmalite nke mmụọ na-eme ka nnagide nke nrụgide anụ ahụ na nke mmetụta uche dị na ndị mmadụ na-arịa nkụchi obi ma ọ bụ ndị nwere nnukwu myocardial. Akụ dị mkpa nke Captopril bụ enweghị mmetụta na uru ọbara mgbali bara mgbe ejiri ya na ọgwụgwọ nke nkụda obi.

Ọzọkwa okpokoro isi na-akwalite ọmarịcha ọbara ọbara na akụrụngwa ọbaran'ihi nke a na-eji ọgwụ ahụ eme ihe n'ọtụtụ ọgwụgwọ nke ọrịa obi na-adịghị ala ala na ọrịa nephropathy.

Captopril ruru eru maka itinye ya na nchịkọta dị iche iche na ndị ọzọ ọgwụ antihypertensive. Na mgbakwunye, Captopril anaghị ejigha mmiri n'ime ahụ, nke na-ekewapụ ya na ọgwụ ndị ọzọ na - egbochi ihe mgbochi nwere ihe onwunwe. Ọ bụ ya mere, mgbe ị na-ewere Captopril, ịkwesighi iji ọgwụ mgbakwunye ọzọ iji kpochapụ edema nke ọgwụ antihypertensive na-akpata.

Nchịkọta izugbe na usoro onunu ogwu

Ekwesịrị iwere Captopril otu awa tupu nri, na-elo mbadamba ihe ahụ kpamkpam, na-akọchaghị ya, na-ata ya ma ọ bụ na-akụri ya n'ụzọ ọ bụla, mana site na ọtụtụ mmiri (ọbụlagodi ọkara iko).

A na-ahọrọ usoro onodu ogwu nke aka a n’otu n’otu, malite na nke kacha nta, ma jiri nwayọ weta ya nke ọma. Mgbe ị theụchara ọgwụ mbụ 6,6 mg ma ọ bụ 12.5 mg, ọbara ọbara kwesịrị ịtụle ọkara elekere ọ bụla maka awa atọ iji chọpụta mmeghachi omume na ịdị njọ nke ọgwụ ahụ n'otu onye. N'ọdịnihu, site na iji usoro onunu ogwu na-abawanye, ekwesịrị ịlele nrụgide kwa oge otu elele mgbe ị takingụ ọgwụ ahụ.

A ga-echetarịrị na ogo kachasị anabata ya kwa ụbọchị nke captopril bụ 300 mg. Theụ ọgwụ ahụ n'ihe karịrị 300 mg kwa ụbọchị anaghị eme ka mbelata ọbara mgbali ike karịa, mana ọ na-akpalite mmụba dị ukwuu na mmetụta nke mmetụta. Ya mere, iwere Captopril na usoro onunu ihe kariri 300 mg kwa ubochi adabaghi.

Captopril maka nrụgide (ya na ọbara mgbali elu) bidoro were 25 mg otu ugboro kwa ụbọchị ma ọ bụ 12.5 mg ugboro abụọ n'ụbọchị. Ọ bụrụ na mgbe izu abụọ gasịrị, ọbara mgbali ahụ agbadaghị n'ụkpụrụ ndị a na-anakwere, mgbe ahụ, a na-abawanye usoro ị andụ mmiri ahụ ma were 25-25 mg ugboro abụọ n'ụbọchị. Ọ bụrụ na mgbe ị na-ewere Captopril na usoro ịba ụba a, nrụgide ahụ anaghị agbada na ụkpụrụ a na-anabata, mgbe ahụ ịkwesịrị ịgbakwunye Hydrochlorothiazide 25 mg kwa ụbọchị ma ọ bụ ndị na-egbochi beta.

Site n'ọbara mgbali elu ma ọ bụ nwayọ, oke onunu ogwu nke captopril na-abụkarị 25 mg ugboro abụọ n'ụbọchị. Na oke ọbara mgbali elu, a na-emezi usoro onyonyo nke Captopril na 50-100 mg ugboro abụọ kwa ụbọchị, na-agbagha ya kwa izu abụọ. Nke ahụ bụ, n'ime izu abụọ mbụ, mmadụ na-ewere 12.5 mg 2 ugboro n'ụbọchị, mgbe ahụ karịa izu abụọ na-esote - 25 mg 2 ugboro n'ụbọchị, wdg.

Site n'ọbara mgbali elu n'ihi ọrịa akụrụ, ekwesịrị ịbara Captopril na 6.25 - 12.5 mg ugboro atọ n'ụbọchị. Ọ bụrụ na mgbe izu 1 - 2 gasịrị, nrụgide ahụ anaghị agbadata na ụkpụrụ a na-anakwere, mgbe ahụ, a na-abawanye usoro onunu ogwu ma were 25 mg 3-4 ugboro n'ụbọchị.

Na nkụda mmụọ obi na-adịghị ala ala Ekwesịrị ịmalite ịmalite Captopril na 6.25 - 12.5 mg ugboro atọ n'ụbọchị. Mgbe izu abụọ gachara, ọnụọgụ ọgwụ ga-agbagide okpukpu abụọ, na-ebute kacha 25 mg ugboro 3 kwa ụbọchị, a na-a theụ ọgwụ ahụ ogologo oge. Na nkụpu obi, a na-eji Captopril ya na njikọ diuretics ma ọ bụ cardiac glycosides.
Ihe ozo Banyere Obi adighi

Na myocardial infarction Enwere ike iburu Captopril n'ụbọchị nke atọ mgbe ngwụsị nke oge oke ahụ gasịrị. N'ime ụbọchị 3-4 mbụ, ọ dị mkpa iji 6.25 mg ugboro abụọ kwa ụbọchị, mgbe ahụ, a na-abawanye ọgwụ ahụ ruo 12.5 mg ugboro abụọ kwa ụbọchị ma drunkụọ mmanya ruo otu izu. Mgbe nke a gasị, site na iji ezigbo ọgwụ ọfụma, a na-atụ aro ka ọ gaa na 12.5 mg ugboro atọ n'ụbọchị maka izu 2 ruo atọ. Mgbe oge a gasịrị, n'okpuru ọnọdụ nke ọgwụ ịhapụ ịhapụ ọgwụ nkịtị, ha na-agbanye 25 mg ugboro atọ kwa ụbọchị na njikwa ọnọdụ izugbe. N'oge usoro ọgwụgwọ a, a na-ewere captopril ogologo oge. Ọ bụrụ na usoro onunu ogwu nke 25 mg ugboro atọ n'ụbọchị ezughi oke, mgbe ahụ ka enyere ya ka ọ nwekwuo ya karịa - 50 mg ugboro atọ n'ụbọchị.
More Banyere Myocardial Infarction

Na-arịa ọrịa shuga nephropathy A na akwadoro Captopril ka o were 25 mg ugboro atọ n'ụbọchị ma ọ bụ 50 mg ugboro abụọ n'ụbọchị. Na microalbuminuria (albumin na mmamịrị) karịa 30 mg kwa ụbọchị, a ga-a drugụ ọgwụ ahụ 50 mg ugboro abụọ kwa ụbọchị, yana proteinuria (protein na mmamịrị) karịa 500 mg kwa ụbọchị Captopril na-a 25ụ 25 mg ugboro atọ kwa ụbọchị. Atụmatụ ndị ahụ egosipụtara na-eji nke nta nke nta, na-amalite site na nke kacha nta, ma na-abawanye ugboro abụọ kwa izu abụọ. Obere nke captopril maka nephropathy nwere ike ịdị iche, n'ihi na a na-ekpebi ya site na ogo nke nrụrụ akụrụ. Obere nke usoro ị ga - ebido were Captopril maka ọrịa nephropathy na-arịa ọrịa shuga, dabere na ọrụ akụrụ ya na-egosi na tebụl.

*Mwepu nke creatinine, ml / min (nke nyocha Reberg kpebisiri ike)*	*Imua ubochi mbu nke Captopril, mg*	*Oke kachasị kwa ụbọchị nke captopril, mg*
40 na n’elu	25 - 50 mg	150 mg
21 – 40	25 mg	100 mg
10 – 20	12.5 mg	75 mg
Erughị 10	6.25 mg	37.5 mg

Ekwesịrị ịkewa usoro ị gosipụtara ụbọchị ọ bụla ka o kee mkpụrụ ọgwụ abụọ ruo atọ kwa ụbọchị. Ndị okenye (karịa 65), agbanyeghị ọrụ akụrụngwa, kwesịrị ịmalite ị theụ ọgwụ ahụ na 6.25 mg ugboro abụọ kwa ụbọchị, ma mgbe izu abụọ gasịrị, ọ bụrụ na ọ dị mkpa, mụbaa usoro iji 12.5 mg 2 ruo ugboro 3 kwa ụbọchị.

Ọ bụrụ na mmadụ na-arịa ọrịa akụrụ ọ bụla (ọ bụghị ọrịa mamịrị nephropathy), mgbe ahụ, usoro ọgwụgwọ nke Captopril maka ya ka a na-ekpebikwa site na njikwa nke creatinine ma ọ bụ otu ihe ahụ na nke ọrịa shuga.

Jiri n’oge ime na inye nwa ara

A machibidoro Captopril ime n'oge afọ ime, ebe ọ bụ na nyocha nyocha na ụmụ anụmanụ egosipụtara na nsonaazụ ya nwere n'ahụ nwa ebu n'afọ. Thenweta ọgwụ site na 13th ruo izu nke 40 nke afọ ime nwere ike ibute ọnwụ nwa ebu n’olu ma ọ bụ mmejọ.

Ọ bụrụ na nwanyị na-ewere isi mmiri, ọ ga-akagbu ozugbo, ozugbo ọ matara banyere mmalite ịtụrụ ime.

Captopril banye n'ime mmiri ara ehi, yabụ ọ bụrụ na ọ dị mkpa, ị ga-ajụ inye nwa ara ma nyefee ya na njikọta anụ.

Ntụziaka pụrụ iche

Maka ụmụaka na-erubeghị afọ 18, a na-eji Captopril eme ihe naanị ma ọ bụrụ na ọnọdụ mberede, na-agbakọ usoro onyonyo n'otu n'otu dabere na ahụ dị, dabere na 1 - 2 mg kwa 1 n'arọ nke ibu kwa ụbọchị.

Ọ bụrụ na nwuru ogwu ọzọ, mgbe ọzọ ị ga-achọ iri nke mbụ, ọ bụghị okpukpu abụọ.

Tupu ịmalite captopril, ọ dị mkpa iweghachi olu nke mmiri na ntinye nke electrolytes n'ime ọbara ma ọ bụrụ na achọtara ha dị oke ala n'ihi ọnya afọ, ọnya siri ike, ọgbụgbọ, wdg.

N'ime oge niile nke iji Captopril, ọ dị mkpa ịchịkwa ọrụ nke akụrụ. N'ime 20% nke ndị mmadụ, mgbe ha na-a theụ ọgwụ ahụ, proteinuria (protein na mmamịrị) nwere ike ịpụta, nke na-agafe onwe ya n'ime izu anọ ruo izu isii na-enweghị ọgwụgwọ ọ bụla. Agbanyeghị, ọ bụrụ na itinye uche na protein n'ime mmamịrị ahụ dị elu karịa 1000 mg kwa ụbọchị (1 g / ụbọchị), mgbe ahụ, a ga-akwụsị ọgwụ ahụ.

Ekwesịrị iji Captopril kpachara anya na nlekọta nlekọta ahụike ma ọ bụrụ na mmadụ nwere ọnọdụ ma ọ bụ ọrịa ndị a:

Sistem vasculitis,
Mee ka ọrịa dị iche iche nke njikọta ahụ,
Biinal akwara akwara Stenosis,
Nnabata nke immunosuppressants (Azathioprine, Cyclophosphamide, wdg), Allopurinol, Procainamide,
Therapyme ọgwụgwọ desensitizing (dịka ọmụmaatụ, bee venom, SIT, wdg).

Were nyocha ọbara niile n’otu izu abụọ na ọnwa atọ mbụ nke ọgwụgwọ. Mgbe nke a gasịrị, a na-eme nyocha ọbara kwa oge, ruo na njedebe nke Captopril. Ọ bụrụ na ngụkọta ọnụ ọgụgụ nke leukocytes na-erughị 1 G / l, mgbe ahụ, a ga-akwụsị ọgwụ ahụ. Ọtụtụ mgbe, ọnụ ọgụgụ nkịtị nke mkpụrụ ndụ ọbara ọcha dị na ọbara na-eweghachi izu abụọ ka ịkwụsị ọgwụ ahụ. Na mgbakwunye, ọ dị mkpa iji chọpụta njupụta nke protein na mmamịrị, yana creatinine, urea, protein na potassium na ngụkọta oge oge ị na-ewere Captopril kwa ọnwa. Ọ bụrụ na itinye uche na protein n'ime mmamịrị dị elu karịa 1000 mg kwa ụbọchị (1 g / ụbọchị), mgbe ahụ, a ga-akwụsị ọgwụ ahụ. Ọ bụrụ n ’ịta urea ma ọ bụ creatinine n’ọbara na-abawanye n’ike n’ihu, mgbe ahụ ị ga-belata usoro ị theụ ọgwụ ahụ ma ọ bụ ya ga-akagbu.

Iji belata ihe ọghọm dị ukwuu na nrụgide na mbido captopril, ọ dị mkpa iji kagbuo usoro ọgwụgwọ ma ọ bụ belata ọgwụ ha site na ugboro 2 ruo atọ ugboro anọ ruo ụbọchị asaa tupu mkpụrụ ọgwụ. Ọ bụrụ na, mgbe ị gachara Captopril, ọbara ọgbụgba na-agbada nke ukwuu, ya bụ, hypotension malitere, mgbe ahụ ị ga-edina n’elu azụ gị n’elu ura ma bulie ụkwụ gị elu ka ha wee dị elu karịa isi gị. Na ọnọdụ a, ọ dị mkpa ịgha ụgha maka nkeji 30-60. Ọ bụrụ na hypotension siri ike, mgbe ahụ iji kpochapụ ya ngwa ngwa, ị nwere ike banye saline nkịtị na-enweghị atụ intravenously.

Ebe ọ bụ na usoro ọgwụgwọ Captopril mbụ na-akpatakarị hypotension, a na-atụ aro ka ịhọrọ usoro ọgwụ ahụ wee malite iji ya n'ụlọ ọgwụ n'okpuru nlekọta nke ndị ọrụ ahụ ike mgbe niile.

N ’zụlite iji Captopril, ihe ọ bụla ịwa ahụ, gụnyere eze (dịka ọmụmaatụ, nha nha eze), ka ejiri nlezianya rụọ. Ojiji nke ịkụnwụ ahụ mgbe ị na-ewere Captopril nwere ike ịkpalite mbelata nke nrụgide, yabụ, a ga-adọ ndị na - anesthetist ahụ aka na mmadụ na-a drugụ ọgwụ a.

Site na mmepe nke jaundice, ị kwesịrị ịhapụ ịkwụsị Captopril ozugbo.

Ruo oge ị ofụ ọgwụ ahụ, a na-atụ aro ka ịhapụ ị ofụ mmanya na-aba n'anya kpamkpam.

Na nzụlite ị theụ ọgwụ ahụ, enwere ike ịchọpụta nyocha ziri ezi maka acetone na mmamịrị, nke dọkịta na onye ọrịa ya kwesịrị iburu n'uche.

Ekwesịrị icheta na ọ bụrụ na ihe ịrịba ama ndị a na-apụta na ndabere nke Captopril, ị kwesịrị ịkpọtụrụ dọkịta ozugbo:

Ọrịa ọ bụla, gụnyere oyi, flu, wdg.
Mmụba mmiri na-abawanye (dịka ọmụmaatụ, na ọgbụgbọ, afọ ọsịsa, ịsụsọ nke ukwuu, wdg).

Ojiji nke captopril na-akpata hyperkalemia mgbe ụfọdụ (ogo dị elu nke potassium n'ime ọbara). Nke kachasị dị oke egwu nke hyperkalemia na ndị mmadụ na-arịa ọrịa mkpọnwụ na-adịghị ala ala ma ọ bụ ọrịa mellitus na-arịa ọrịa, yana ndị na-eso nri na-enweghị nnu. Ya mere, megide ndabere nke iji Captopril, ọ dị mkpa ịjụ ị potassiumụ mkpụrụ ọgwụ na-akpata ọgwụ (Veroshpiron, Spironolactone, wdg), nkwado potassium (Asparkam, Panangin, wdg) na heparin.

Na-emegide usoro iji Captopril, mmadụ nwere ike ịmalite ime ahụ ihe, nke na-ewerekarị na izu anọ nke ọgwụgwọ ma na-apụ na mbelata usoro ma ọ bụ na nchịkwa ọgwụ antihistamines (dịka Parlazin, Suprastin, Fenistil, Claritin, Erius, Telfast, wdg). Ọzọkwa, mgbe ị na-ewere Captopril, ụkwara na-adịghị ala ala (na-enweghị nchapu akpa ume), ntanetị uto uto na oke ibu nwere ike ịme, na -eche, mmetụta ndị a niile na-apụ n'anya ọnwa 2 ruo ọnwa atọ kwụsịrị ọgwụ ahụ.

Mmekọrịta na ọgwụ ndị ọzọ

Captopril na-akwalite mmetụta nke ọgwụ hypoglycemic (Metformin, Glibenclamide, Gliclazide, Miglitol, Sulfonylurea, wdg), ya mere, mgbe ha jikọtara ọnụ, a ga-enyocha ọkwa glucose ọbara. Na mgbakwunye, Captopril na-akwalite nsonaazụ ọgwụ maka anesthesia, painkillers na mmanya.

Diuretics na vasodilators, antidepressants, antipsychotics, Minoxidil na Baclofen na-abawanye mmetụta hypotensive nke Captopril, n'ihi nke, mgbe ejikọtara ọnụ, ọbara mgbali nwere ike belata nke ọma. Ndị na-egbochi Beta-blockers, ndị na-egbochi ganglion, pergolide na interleukin-3 na-eme ka mmetụta Captopril dịkwuo ala belata, n'etinyeghị mgbali dị elu.

Mgbe ị na-eji captopril na nitrates (nitroglycerin, sodium nitroprusside, wdg), ọ dị mkpa iji belata usoro nke ikpeazụ.

NSAIDs (Indomethacin, Aspirin, Ibuprofen, Nimesulide, Nise, Movalis, Ketanov, wdg), aluminom hydroxide, magnesium hydroxide, carbonate hydroxide, orlistat na clonidine belata ịdị njọ nke Captopril.

Captopril na - eme ka ị nweta lithium na digoxin n'ime ọbara. N'otu aka ahụ, iji Captopril na-akwadebe lithium nwere ike ịkpasu mmepe nke mgbaàmà nke ịxụ mmanya na-egbu lithium.

Ihe eji emechi ya na captopril na immunosuppressants (Azathioprine, Cyclophosphamide, wdg), Allopurinol, ma obu Procainamide na-abawanye ohere nke neutropenia (iwetulata ọkwa sel ọbara dị ala karịa nke nkịtị) yana ọrịa Stevens-Johnson.

Ojiji nke captopril megide usoro nke usoro ọgwụgwọ desensitizing na-aga n'ihu, yana yana yana estramustine na gliptins (linagliptin, sitagliptin, wdg) na-abawanye ohere nke mmeghachi omume anaphylactic.

Ihe eji eji akuko eji aru eji aru kpuchie oria edo (Aurothiomolate na ndi ozo) na achapu akpukpo aru, ọgbụgbọ, ọgbụgbọ na mbelata ọbara mgbali.

Mmetụta akụkụ nke Captopril

Mbadamba ụrọ Captopril nwere ike ibute nsonaazụ ndị a na - esite na akụkụ na sistem dị iche iche:

1.Sistemerụọkụ na akụrụngwa anụ ahụ:

Ike ọgwụgwụ,
Dizziness
Isi ọwụwa
Mmegbu nke usoro ụjọ ahụ,
Rowsjọ
Mgbagha,
Obi erughị ala
Ataxia (nhazi nke mmegharị).
Mmepo
Paresthesia (mmetụta nke ọnụọgụ, ịsụ ngọngọ, "ọgazị ụkwụ") n'ụkwụ ya ",
Ọhụhụ adịghị n'ọhụụ ma ọ bụ isi,
Ọrịa ire ụtọ
Ike gwụrụ.

2.Usoro obi na ọbara:

Hypotension (ọbara mgbali ala)
Nnukwu nsogbu nke Orthostatic (mbelata nke nrụgide mgbe ị na-esikwa n'ọnọdụ ọdụ ma ọ bụ n'ụgha gaa n'ọnọdụ nkwụnye),
Angina pectoris,
Myocardial infarction
Arrhythmia
Ọkpụkpụ obi
Ọrịa ụbụrụ,
Ime akụkụ ụbụrụ,
Lymphadenopathy
Ọbara
Obi mgbu
Ọrịa Raynaud
Na ebili mmiri
Pallor nke anụ ahụ
Cardiogenic ujo,
Mkpụrụ ọgwụ thromboembolism
Neutropenia (ibelata ọnụ ọgụgụ nke neutrophils n'ime ọbara),
Agranulocytosis (mkpochasị nke basophils, eosinophils na neutrophils n'ọbara),
Thrombocytopenia (ibelata na platelet dị n'okpuru nkịtị),
Eosinophilia (mmụba n'ọnụ ọgụgụ eosinophils karịa nke nkịtị).

3.Usoro okuku ume:

Bronchospasm,
Ntutu ume
Ọrịa ịba ọcha n'anya
Ọrịa afọ
Rhinitis
Ụkwara na - enweghị mkpụrụ (na - ewepụtaghị ekpompụta).

4.Ọkpụkpụ afọ:

Anorexia
Ọrịa ire ụtọ
Stomatitis
Ọ na-eme ka akpụkpọ ahụ mucous nke ọnụ na afọ,
Xerostomia (akọrọ akọrọ n'ihi ezughi oke onu),
Nnukwu oria (mbufụt nke ire),
Hyperplasia Gingival,
Ilo ihe isi ike,
Ahụ erughị ala
Vomiting
Dyspepsia (flatulence, bloating, abdominal mgbu, mmetụta nke oke na afo mgbe eri, wdg),
Ntachi
Ọrịa afọ ọsịsa
Ọrịa mgbu
Cholestasis
Cholestatic ịba ọcha n'anya
Hepatocellular cirrhosis.

5.Usoro uto na omumu:

Ọrụ akụrụngwa na-arụ ọrụ, ruo na nnukwu nnukwu akụrụ oke,
Polyuria (mmụpụta mmụba dị elu karịa nke kwesịrị).
Oliguria (mmeputa mmamịrị mbelata nke nkịtị),
Proteinuria (protein n’ime mmamịrị),
Ugboro ugboro na ọnya ịba ụba
Enweghị ike.

6.Ahụ na anụ ahụ dị nro:

Ọcha na-acha uhie uhie
Ihe nfuta n’ahu
Akpụkpọ ahụ
Exemoliative dermatitis,
Necrolysis na-egbu egbu
Pemphigus
Erythroderma,
Tinea versicolor
Alopecia (isi nkwọcha),
Photodermatitis.

7.Mmeghachi omume nfụkasị ahụ:

Stevens-Johnson Syndrome
Urticaria,
Imeji Quincke,
Anafilactic ujo.

8.Ndị ọzọ:

Ahụ Ikpo Ọkụ
Chi
Sepsis (nsị ọbara),
Arthralgia (nkwonkwo mgbu)
Myalgia (olu mgbu),
Hyperkalemia (mụbara na potassium n'ime ọbara dị elu karịa nkịtị),
Hyponatremia (mbelata ọkwa nke sodium n'ọbara dị ala karịa),
Hypoglycemia (glucose ọbara dị ala) n'ime ndị mmadụ n'otu oge na-a insụ insulin ma ọ bụ ọgwụ hypoglycemic ọzọ,
Gynecomastia
Ọrịa ọbara
Mmụba ọrụ enzymes imeju (AsAT, AlAT, alkaline phosphatase, wdg),
Mmụba nke urea, creatinine na bilirubin n'ọbara, yana ESR,
Hemoglobin na hematocrit belatara
Acidosis
Testgha nyocha dị mma maka ọnụnọ nke ọgwụ nje nuklia.

Captopril - Analogs

Ugbu a, n'ahịa ọgwụ ụlọ, Captopril nwere ụdị analogues abụọ - ihe ndị a bụ nnọchi anya, n'eziokwu, analogues. Mmekorita gunyere ogwu nke nwere otu ihe aru oru di ka Captopril. Analogues gụnyere ọgwụ nwere ihe dị ike dị iche na Captopril, mana so n'òtù ndị na - egbochi ACE na, n'ihi ya, nwere ụdị ọgwụgwọ ahụ.

Ihe jikọrọ ya na Captopril Ọgwụ ndị a:

Mbadamba Angiopril-25,
Mbadamba ụrọ Blockordil
Mbadamba ụrọ Kapoten.

Captopril analogues sitere na otu ndị ACE inhibitors bụ ọgwụ ndị a:

Ọgwụ Acupro
Mbadamba amprilan
Mbadamba Arentopres,
Mbadamba ụrọ Bagopril
Burlipril 5, Burlipril 10, Burlipril 20 mbadamba,
Wazolong Capsules,
Ọgwụ Hypernova,
Hopten okpu,
Mbadamba Dapril
Dilaprel capsules,
Mpekere diropress
Mbadamba Diroton
Zokardis 7.5 na mbadamba 30,
Mbadamba Zonixem
Mbadamba inhibeys,
Mbadamba akwụkwọ
Mbadamba Quadropril
Mbadamba Quinafar,
Mbadamba ụrọ,
Mbadamba nkume Corpril
Mbadamba ụrọ Lysacard,
Mbadamba ụrọ nke Lysigamma,
Mbadamba ụrọ Lisinopril,
Mbadamba nke Lisinotone,
Mbadamba ụrọ Lysiprex
Mbadamba ụrọ Lizonorm,
Mbadamba ụrọ Lysoril
Mbadamba edemede
Mbadamba liten
Mbadamba nke Methiapril,
Mbadamba Monopril
Moex 7.5 na Moex mbadamba 15,
Mbadamba nkume ndị dị na Parnawel,
Mbadamba ụrọ nke Perindopril
Mbadamba ụrọ Perineva na Perineva Ku-tab,
Mbadamba Perinpress
Mbadamba Pyramil
Mbadamba Pyristar,
Ere ọgwụ,
Prestarium na Prestarium mbadamba nkume,
Mbadamba Ramigamma,
Ramicardia okpu,
Mbadamba ụrọ Ramipril
Mbadamba ụrọ,
Mbadamba ụrọ Renipril
Mbadamba Renitec
Mbadamba ụrọ Rileys-Sanovel,
Mbadamba Sinopril
Ere ahịa
Mbadamba ụrọ Tritace,
Mbadamba ụrọ Fosicard,
Mbadamba ụrọ Fosinap,
Mbadamba ụrọ Fosinopril,
Mbadamba ụrọ Fosinotec
Mbadamba Hartil
Mbadamba nke Hinapril,
Mbadamba Ednit
Mbadamba ụrọ Enalapril,
Mbadamba enam
Enap na Enap P mbadamba,
Mbadamba ụrọ enarenal
Mbadamba nke Enapharm,
Ọgwụ Envas.

Ọtụtụ nyocha nke Captopril (ihe karịrị 85%) dị mma, n'ihi ịdị irè nke ọgwụ iji belata ọbara mgbali elu. Nyocha ndị ahụ gosipụtara na ọgwụ ahụ na-eme ngwa ngwa ma kwụsịlata nrụgide, si otú a na-ahụkarị ọdịmma. Nyocha ndị ahụ gosikwara na Captopril bụ ọgwụ kachasị mma maka mbelata ọnọdụ mberede nke mgbali elu. Agbanyeghị, maka iji ọbara mgbali elu ogologo oge, Captopril abụghị usoro ịhọrọ, ebe ọ nwere ọnụọgụ mmetụta dị iche iche na-ahụghị na ọgwụ ọhụụ.

Nyocha ole na ole na-adịghị mma banyere Captopril ha na-abụkarị site na mmepe nke mmetụta ndị nwere nnukwu nsogbu ndị na-akwali ịhapụ ị .ụ ọgwụ ahụ.

Captopril ka ọ bụ Enalapril?

Captopril na Enalapril bụ ọgwụ analogous, ya bụ, ha bụ otu otu ọgwụ ma nwee ụdị ọrụ ọzọ. Nke a pụtara na ma isi ala ma enalapril ọbara mgbali elu ma melite ọnọdụ obi na nkụda obi na-adịghị ala ala. Agbanyeghị, enwere ụfọdụ ọdịiche dị n'etiti ọgwụ ndị ahụ.

Nke izizi, maka ọbara mgbali elu dị nwayọ ruo obere, Enalapril ezuola iji were ya otu ụbọchị kwa ụbọchị, Captopril kwesịrị ị drunkụ mmanya ugboro abụọ n'ụbọchị n'ihi obere oge ọ ga-eme. Na mgbakwunye, enalapril ka na-ejigide nrụgide na ọkwa nkịtị yana iji ogologo oge.

Ya mere, anyị nwere ike ikwubi na enalapril bụ ọgwụ ka akwadoro maka iji ogologo oge iji nọgide na-enwe ọbara mgbali n'ime ụkpụrụ a na-anabata. Na Captopril dabara adaba maka mbelata akụkụ nke nrụgide na-arị elu.

Agbanyeghị, Captopril, ma e jiri ya tụnyere Enalapril, nwere nsonaazụ ka mma na ọnọdụ nke obi na nkụda obi na-adịghị ala ala, na-eme ka ndụ dịkwuo mma, na-abawanye nnabata nke anụ ahụ na nsogbu ndị ọzọ, na-egbochikwa ọnwụ na mberede. Ya mere, n'ihe banyere ọrịa obi na-ekweghị ala ala ma ọ bụ ọrịa obi ndị ọzọ, captopril ga-abụ ọgwụ kachasị amasị.
Ndị ọzọ na Enalapril