Crestor: nyocha nke ndị ọrịa na-a theụ ọgwụ ahụ

ọgwụ	10 mg	28 pcs.	≈ 1950,9 rubles
	10 mg	98 nkp.	≈ 5365.1 rubles
	20 mg	28 pcs.	≈ 4416.5 rub.
	40 mg	28 pcs.	≈ 5890 nkp.
	5 mg	28 pcs.	≈ 2123 rub.
	5 mg	98 nkp.	≈ 5595 nkp.

Ndị dọkịta na-atụle nyocha banyere obe

Rating 1.3 / 5

Irè

Ahịa / mma

Nsonaazụ

Otu n'ime ihe ndị kachasị arụ ọrụ.

Hepatotoxicity. Nke ahụ bụ, site na uru enwere ike, anyị ekwela nkwa mmerụ ahụ.

Kemgbe afọ 70s, a na-agbaso amụma ozi na United States iji zụlite ezigbo ndụ na ndị America. N'ihi ya, ndị na-akwụ ndị America ụgwọ ezumike nká taa na-anabata ALT na AST kwa ọnwa 3 ọ bụrụ na ha na-ewere statins. Ọ dị nwute, anyị enweghị ụdị iwu a.

Ikwu oke 3.3 / 5

Irè

Ahịa / mma

Nsonaazụ

"Crestor" bụ otu n'ime akpụ mbụ mbụ, ebumnuche nke ekwesiri ịtụle ya mgbe ị na - ejikọ nrụrụ erectile na dyslipidemia. Ọ bụghị ihe ọjọọ na-eme profaịlụ egbugbere ọnụ ya. Site na usoro ọgwụgwọ ejikọtara nke ọma, a na-ahụ nsonaazụ ọma izizi nke sistemụ nrụrụ ka ọnwa 2-3 gachara. A na-ahọrọ ọgwụ ahụ n’otu n’otu, dabere na profaịlụ akwara. Nkwanye ọgwụ mgbochi nke antioxidants.

Ọgwụ ahụ dị oke ọnụ, mana o doro anya na Krestor bara uru. Ihe enwere ike ịrụ ọrụ ọrụ imeju.

Rating 4.2 / 5

Irè

Ahịa / mma

Nsonaazụ

Ọ na - enyere aka n'ezie, ọkwa LDL na - agbada, ọ ga - adị irè naanị site na iji usoro ọgwụgwọ ya, yabụ ịkwesighi ịkwụsị ị theụ ọgwụ ahụ mgbe emechara ọgwụgwọ ọgwụgwọ na - enye afọ ojuju.

Ssụ ọgwụ echebara echiche nke ọma na-eme ka ọ dị mfe ma dịkwa mma iji chịkwaa cholesterol ọbara.

Rating 4.6 / 5

Irè

Ahịa / mma

Nsonaazụ

Statin kachasị amasị. Ee, onye m hụrụ n'anya, mana ọ nwere ezi ihe kpatara ya. Ogwu izizi, i.e. nyocha emere nke ọma. Iri oke dị mma, mbelata oke nwere ike ịtụ anya. Elegharala nchịkwa nke enzymes imeju ka ị na-ewere "Crestor" ma ọ bụ statin ọ bụla ọzọ. Ọ dị mma, na, n'ezie, echefula na oriri statin kwesịrị ịdị, na-enweghị atụ, na-adịgide adịgide, ọ bụghịkwa.

Ikwu oke 2.9 / 5

Irè

Ahịa / mma

Nsonaazụ

Ọgwụ ochie, rosuvastastine. Ọ na-eme cholesterol nke ọma. Ngosipụta nke oma maka mgbochi bụ isi nsogbu nsogbu akwara.

Ọgwụ dị oke ọnụ, ọ bụghị mmadụ niile ga-emeli ya.

N'oge nnabata, ịchịkwa profaịlụ akwara na ALT, AST dị mkpa. A na-ewere ya otu oge n’ụbọchị, na mgbede.

Ikwu oke 3.8 / 5

Irè

Ahịa / mma

Nsonaazụ

Krestor bu ezigbo ogwu nke akuko niile. Site n'ihe ndabere. Mgbe ọnwa 1.5-2 nke iji na-aga n’ihu, nsonaazụ pụtara. Edere ya otu oge kwa ụbọchị, a na-ahọrọ usoro onyonyo otu n'otu, mgbe ị na-a theụ ọgwụ ahụ, na-achịkwa oke ahụ dị n'ọbara, ALT, AST.

Ọnụahịa ahụ dị oke elu, ọ bụghị ndị ọrịa niile dị.

Anabataghị ọgwụ a, ana m akwado ya maka ndị ọrịa.

Ikwu oke 3.3 / 5

Irè

Ahịa / mma

Nsonaazụ

Ruo ọnwa abụọ, a họpụtaghị onye na-eme baptizim, karịsịa, "iji gbochie mmepe nke paịlị." Krestor gosipụtara ikike iji belata nha ihe echiche naanị mgbe afọ nchịkwa afọ abụọ gasịrị na 40 mg kwa ụbọchị. Na mkpokọta, ọ bụrụ na akụnụba ego kwere, ọ nweghị ihe dị mma karịa ọgwụ mbụ. Na rosuvastatin mbụ bụ Krestor. Ma ọ bụrụ na ajụjụ a bụ: ma ọ bụ ka a ghara ịgwọ ya ma ọlị, ma ọ bụ iji mejupụta ọnya dị elu, mgbe ahụ, n'eziokwu, ụdị njirimara dị mma ka mma. Ọ dị mma icheta na nsonaazụ niile nke ogologo oge nke rosuvastatin - mbelata ọnwụ, ọnwụ nke infarction myocardial na ọrịa strok - gosipụtara naanị maka Crestor, n'ihi na amụghị ihe ọmụmụ ahụ n'ụzọ dị otu a. Agbanyeghị, dịka ụdị mkpụrụ ndụ dị mma kwesịrị isi mee ka mbelata nke cholesterol dị n'ọbara, ekwesịrị igosipụta nke a n'ọmụmụ ihe ndị dị mkpa.

Nanị ihe ndọghachi azụ bụ ọnụ ahịa ya. Karịsịa ugbu a, mgbe mgbanwe mgbanwe mgbanwe. Onye nwere ike ịkwụ ụgwọ - hapụ ya zụta. Should kwesịrị ịmara na iji ọgwụgwọ ọ bụla emeghị ka cholesterol dị ala, kama iji belata ihe ize ndụ nke infarction myocardial, ọrịa ọnya afọ na ọnwụ site na ihe kpatara ọrịa obi. Ọ bụ ya mere a ga-eji were statins ruo ọtụtụ afọ. Mgbe ahụ ị ga-enwe ntụkwasị obi karịa na nsogbu ndị ae kwupụtara. Ọ bụrụ na obe hụrụ gị n'anya, mgbe ahụ ọ ka mma ịmalite ụdị jenerato ozugbo. N'ihi na a gaghị ahụta uru amamịghe site na iwere ya n’ime ọnwa abụọ na-atọ. O doro anya na cholesterol ga-agbadata, mana, site na nke buru ibu, a na-ewere statins ka ọ ghara belata cholesterol, kama iji belata ihe egwu nke nsogbu n'ụdị infarction myocardial, ọrịa strok, wdg. Ihe egwu a, dịka iwu, malitere ịbelata naanị mgbe ọtụtụ ọnwa gachara site na mmalite nke ịmalite statins.

Ọ bụrụ na nsonaazụ ya mere na otu onye ọrịa, nke a apụtaghị na otu ihe ga-eme ndị ọzọ niile. Yabụ, ebe ị gechara ntị n’otu onye natara obe (ma ọ bụ ihe ọ bụla ọzọ) nke natara ihe na-adịghị mma, n’aghaghị ịnara nke a na akaụntụ gị. Ọ naghị ekwe omume ịkọ ihe ọghọm nsonaazụ n'otu onye ọrịa. Naanị ịchọrọ ịghọta na ọ bara uru ka ejiri obe na-emeso gị mgbe ị ga-enwe ike ịzụta ya ruo ọtụtụ afọ. Ma ọ bụghị ya, zụta ụdị ngwa-ngwa ozugbo ma mesoo ya (dịka ọmụmaatụ, mertenyl, ma ọ bụ roxer, ma ọ bụ tevastor).

Rating 4.2 / 5

Irè

Ahịa / mma

Nsonaazụ

Drugzọ kachasị mma nke statins niile. Ngwa ngwa cholesterol na ọkwa nke a chọrọ. N'adịghị ka analogues, ọgwụgwọ ọgwụgwọ ọbụna na usoro dị ala.

N'ezie, ọnụahịa ahụ buru ibu! Enweghị esemokwu. Ọ bụghị mmadụ niile ga-emeli ya.

Ọgwụ ochie. Ihe akaebe na-atọ ụtọ. Mana ọnụahịa ahụ na-atụ ụjọ ọtụtụ ndị ọrịa chọrọ ya.

Ikwu oke 3.3 / 5

Irè

Ahịa / mma

Nsonaazụ

Ọ na - edozi ọkwa cholesterol ngwa ngwa (n'otu izu ọ nwere ike belata ndị na - egosi ya na nkịtị).

A na-amụ ọgwụ ahụ nke ọma, yana nnukwu ihe akaebe dị na ya, ọmarịcha mma. Ọ na-arụ ọrụ nke ọma na obere doses ma e jiri ya tụnyere ọgwụ ndị ọzọ na otu a. Anabatụrụ nke ọma. N'ọnọdụ ka ukwuu, a na-ewere ya n'ihu.

Ndị ọrịa na-enyocha ihe gbasara obe

Ejuru m Krestor izu abụọ, mọzụlụ ụkwụ m bidoro merụọ ahụ, enweghị m ike ihi ụra, m na-ebu ọgwụ mgbu, otu izu gafere. Mgbe ekpochapụchara ihe mgbu ahụ, a ka nwere ọnya na-egbu mgbu na akpụkpọ ahụ mgbe enwere ya aka, m ga-eche izu ọzọ ruo mgbe ewepụrụ ọgwụ ahụ n'ahụ, ọ bụrụ na ihe mgbu ahụ adịgide, aga m agakwuru dọkịta na-agwọ ọrịa akwara. N'iji ya, ịkwesịrị ị attentiona ntị n'ihe edere na ntuziaka ahụ, amabeghịkwa ọnọdụ ọnya ahụ dị. Kpachara anya, ọ dị ka a chọghị ọgwụ ahụ kpamkpam.

Otu enyi na Canada nwụrụ n'ọrịa kansa. Ihe mbu onye oncologist emechara mgbe ochoputara oria bu ide ogwu nile o na -a. Otu n'ime ha bụ obe. Ọ machibidoro ya iwu ozugbo. Ọ bụrụ na Kanada, ha na-anwa ịghara ịhọpụta ya. Enwere enyo siri ike na ọgwụ a na-akpata ọrịa kansa.

Papa m Kụrụ Krestor afọ atọ. Ogwu a mebere cholesterol belata nke oma. Ha chọrọ ịkwụsị ị theụ ọgwụ ahụ, mana ọ gwụsịrị, kọlestrọl bilitere ọzọ. Ọ bụ ya mere m ga-eji bido ị takingụ ọgwụ. Mgbe nke a gasịrị, papa m malitere ime mkpesa banyere isi ọwụwa, ahụike na-adịghị mma, ụra na-adịghị mma. Anyị chọpụtara ihe kpatara ogologo oge, gafere ule dị iche iche. Na njedebe, ọ bịara bụrụ na nna ya nwere nsogbu imeju. Iji ọgwụ ọjọọ eme ihe aghọwo ihe na-agaghị ekwe omume.

Obi dị m ụtọ na ị theụ ọgwụ a, na-ebelata ngwa ngwa ọ fọrọ obere ka ọ ghara inwe mmetụta ọ bụla. Naanị oge ezumike m na-a Eụ Mkpa Ike Forte N.

Dọkịta ahụ kwụsịrị ọnwa abụọ iji gbochie mmepe nke ihe ncheta. Zụtara (dị ka nke mbụ). Enwetụbeghị ụdị rashes dị otú a na ndụ m! Kindfọdụ ụdị ihe ọkụ ọkụ na-efe efe n'ahụ niile. Anụrụ m a dayụ mmanya ụbọchị 4, maka na echere m na ọ ga-ekwe omume ndị Magnerot jikọrọ aka. Achọpụtara m nke ahụ na Krestor. Ebi esi ebi? Ike na-agwụ tufuo ya pụta.

Myocardial infarction mere ka m chee ma chee ihe m jiri ahụike m! Ọbụna gara simulator. Egotere cholesterol m nke ukwuu, n'ihi ya, ha debere nri siri ike, na sie ma sie steamed naanị, Obi dị m ụtọ na m nwere ike iri mkpụrụ osisi, kwachibidoro ị smokingụ sịga, ọ siri ike ihe a niile. Anwalere m Krestor - Anabatara m ya dị ka enyere n'iwu, mana ahụbeghị m mmeghachi omume nfụkasị ọ bụla. Ọ bịara dị mfe iku ume, gbakwunyere m, m na ndị na-enye ọzụzụ na-agba ọsọ. Erere na-enyere aka, mana mmega ahụ dịkwa mma. Amaghị m, mana m na-emeso ọgwụ ọzọ ka oge na-aga, ka m ghara iji ya mee ihe, m kwụsịtụrụ ọgwụgwọ.

Di m onye ka idere obe tinye ya na obi obi. Ihe nyocha gosiri na o nwere cholesterol dị ukwuu n'ime ọbara ahụ ya mere ọ dị mkpa iji belata ihe ngosi ndị a ngwa ngwa. Site na ị thisụ ọgwụ a mgbe niile yana na nri siri ike, ọkwa cholesterol ji nwayọọ nwayọọ malite iju. Naanị mgbe otu ọnwa gachara nyocha ahụ gosiri na cholesterol ọbara dị larịị. Dọkịta tụrụ aro ka e were ya mgbe nke ahụ mechara, mana ọ bụ ọgwụ dị oke ọnụ ma ọ bụghị mmadụ niile nwere ike ịkwụ ya were ogologo oge.

Nkọwapụta dị mkpirikpi

Krestor (ihe a na-arụ ọrụ bụ rosuvastatin) bụ ọgwụ ọgwụ nwere ike ịmịcha mmiri nke bụ nke otu ndị na-egbochi enzyme HMG-CoA reductase, nke a ka amata na statins. Ebube nke “ebe nguzo nke” ọgbụgba akwara ọbara dịlarịrị mba anyị ogologo oge. Ọbara mgbali elu mechara bụrụ otu ihe na - akpata nkwarụ na ọnwụ site na ọrịa obi. Ọ bụghị ihe nzuzo na mmepe nke ọbara ọgbụgba akwara na-aga ụkwụ na aka n'ọbara ọrịa dị iche iche, dịka glucose anabataghị, hyperinsulinemia (oke insulin insulin), hypeuricemia (oke uric acid n'ime ọbara), oke ibu na dyslipidemia (metabolism lipid metabolism). N'okwu nke abụọ, ọbara ọgbụgba na-esonye na mmụba nke ọdịnaya ụmụ irighiri akwara atherogenic na, n'ihi nke a, mmepe nke atherosclerosis. Dabere na nsonaazụ nyocha, hypercholesterolemia na-aputa ihe kariri 40% nke nsogbu nyocha ọbara mgbali elu. N'ụzọ na-akpali mmasị, n'ime ndị ọrịa nwere oke ọbara, ihe na-eme ka mmiri dị ntakịrị karịa atherogenic ma e jiri ya tụnyere ụmụ nwanyị. Nlebara anya ezughi oke na mgbazi nke ọbara mgbali, yana iwepu ihe ndị nwere ike ibute ọrịa obi, gụnyere dyslipidemia, na - eduga mmepe na ọganihu nke atherosclerosis. N'akụkụ a, mmezi nke metabolism nke anụ ahụ bụ otu n'ime ebumnuche kachasị mkpa nke ijikwa ndị ọrịa nwere ọbara mgbali elu, ụzọ isi nweta nke, yana imeziwanye ụzọ ndụ, bụ ojiji nke statins. Nsonaazụ nke nnwale dị ukwuu nke ụlọ ọgwụ na-egosi nke ọma na akpụ akpụ na-ebelata ihe egwu nke ihe omume obi. Ọnọdụ pụrụ iche n'etiti ndị nnọchite otu a na-ere ọgwụ na rosuvastatin (obe), n'ihi ọnụnọ nke ụwa niile amaara karịa "ndị ọrụ ibe ụlọ ahịa". Krestor bụ ọgwụ na-eme ka ọ pụta ìhè na-eji akụrụngwa kemgbe 2003. A mụọla ọgwụgwọ ya nke ọma n'ọtụtụ ule, jikọtara n'okpuru aha izugbe GALAXY na-ekpuchi ihe karịrị ndị puku iri anọ na ise.

N'ime usoro ihe omume a, mmetụta dị mma nke ọgwụ nwere na profaịlụ anụ ahụ, ihe akara nke mbufụt na-arụ ọrụ, ekwenyela na usoro nke usoro atherosclerotic. Mgbe ị na-eji obe n’oghere usoro onyonyo a tụrụ aro ya, mbelata ọkwa cholesterol (LDL) “nke jọrọ njọ” site na 52-63%, nke kariri ụkpụrụ nha ọzọ maka onyonyo ndị ọzọ. Na mgbakwunye, mgbe a na-eji obe, ọkwa nke cholesterol dị mma (HDL) na-ekwe nkwa ịbawanye - site na nkezi 14%, na-agbada n'otu oge na triglycerides. Nyere na oru ikpere mmeghachi omume mbufụt na pathogenesis nke atherosclerosis abughi onye nwere obi abụọ ugbu a, a na-elebara anya pụrụ iche maka ihe doro anya maka mmetụta mgbochi mkpali nke obe. Emere omumu ihe omumu nke ogwu ahu gosiputara odi nma ya na akwara obi na atherosclerosis: oria abuo n’agha gosiputara uru obughi na ime ka ihe omimi ghara idi ire, ya na ikwuputa atherosclerosis na akwara obi na akwara. Yabụ, a na-ahụ obe n'ụzọ ziri ezi ọgwụ na-ekwe nkwa ọ bụghị naanị n'ihe metụtara nzizi nke profaịlụ lipid, kamakwa igbochi mmepe nke atherosclerosis. Ojiji eji obe eme ihe nke oma na mgbochi nke ukwu nke oria obi. Mmetụta ogwugwo nke ọgwụ ahụ na-amalite n'ime ụbọchị 7, mgbe ọnwa gasịrị n'izu izu nke ọgwụ ọgwụ agbagoro elu.

A na-emepụta obe ahụ na mbadamba ụrọ, nke a ga-elo mmiri kpamkpam, ọ bụghị nke a gweriri ya, were mmiri zuru oke were sachaa ya. Enwere ike ị drugụ ọgwụ ahụ n'oge ọ bụla n'ụbọchị. Tupu na mgbe ọgwụgwọ ya, onye ọrịa ahụ ga-agbaso ụdị nri hypocholesterolemic ọdịnala. A na-ahọrọ ọ̀ka nke obe n’otu n’otu dabere ebumnuche ọgwụgwọ, mmetụta a chọpụtara na nnagide ndidi.

Crestor: ntuziaka maka ojiji

Omume ọgwụ	Krestor belata cholesterol LDL nke "jọrọ njọ" n'ime ọbara, na-egbochi akụkụ nke imeju ya. Ọ na - ebelata mkpụkọ triglycerides, apolipoprotein B, obere lipoproteins dị mkpụmkpụ (VLDL). Na ewelite cholesterol HDL nke “di nma”. Na-ebelata mbufụt nke na-adịghị ala ala n’ime arịa. Na-emezi protein C-reactive na akara ndị ọzọ nke mmerụ ahụ. Nsonaazụ nke nyocha ọbara malitere imeziwanye mgbe izu 1-2 gachara, nsonaazụ kachasị - mgbe izu 2-4 gachara.
Mlọ ọgwụ	Enwere ike iburu mbadamba Rosuvastatin na nri ma ọ bụ na afọ efu, ịdị irè nke a anaghị agbanwe. Rosuvastatin kewapụrụ anụ ahụ site na 90% site na imeju site na eriri afọ, site na 10% - site na akụrụ. Ọ dị obere karịa ihe oyiyi ndị ọzọ, ọ na-ebunye sistem imeju na-etinye aka na nhicha ọbara nke ihe ndị na-arụ ọrụ nke ọgwụ. N'ihi nke a, ya na ndị ọgwụ ndị ọzọ nwere mmekọrịta mmekọrịta na-adịghị mma karịa ọkwa ọgbọ gara aga.
Ihe ngosi maka ojiji	Cholesterol di elu n’etiti ndi okenye na ndi toro eto. Ihe mgbochi nke mmepe nke atherosclerosis. Mgbochi nke nkụchi obi mbụ na nke ugboro ugboro, ọnya afọ ischemic na nsogbu ndị ọzọ nke atherosclerosis. Mgbe a wachara ya ahụ iji weghachi ọbara ọgbụgba n'ime arịa ndị atherosclerosis metụtara. Mmụba protin na-enye ume ọrụ n’ọbara n’ihu ihe ndị ọzọ dị ize ndụ obi, ọ bụrụgodị na kọlestrọl bụ ihe dị mma. Iwere mbadamba Krestor abụghị ihe a ga-eji dochie anya ibi ndụ dị mma. Mụọ isiokwu ahụ bụ "Mgbochi nke nkụchi obi na ọrịa strok" ma mee ihe o kwuru. Ma ọ bụghị ya, ọgwụ ahụ ga-enyere obere aka.

Hụ vidiyo ahụ:

Usoro onunu ogwu	Bido na usoro onunu ogwu nke 5 ma obu 10 mg kwa ubochi. Ka izu anọ gachara, enwere ike ịba ụba nke Krestor, nye etu etu cholesterol si agbanwe ka oge a na etu onye ọrịa si anabata ọgwụgwọ. Mụta cholesterol ọbara maka ụmụ nwoke na ụmụ nwanyị n’afọ. Ọtụtụ mgbe, ndị ọrịa na-ewere rosuvastatin 10-20 mg kwa ụbọchị. A na-atụkarị ọgwụ kachasị maka 40 mg ka ndị mmadụ kọlestrọl dị elu n'ihi nsogbu mkpụrụ ndụ. Ndị okenye, yana ndị ọrịa nwere obere akụrụ ma ọ bụ ọrịa ịba ọcha n'anya, ka a na-atụzi rosuvastatin na usoro onodu a.
Nsonaazụ	Mbadamba nke Krestor, dị ka ihe onyonyo ndị ọzọ, nwere ike ibute mgbu akwara, ike ọgwụgwụ, ike ọgwụgwụ, ncheta na nsogbu iche echiche, ihe ọghọm, na nsogbu.Lelee edemede “Mmetụta akụkụ nke statins” - chọpụta otu esi belata ọrịa ndị na-adịghị mma ma ọ bụ wepu ha kpam kpam. Nkwadebe Rosuvastatin nwere mmetụta dị iche iche ha nwere. Gụkwuo ka nchekwa rosuvastatin dị nchebe. Maka ndị nwere nnukwu nkụchi obi na nkụchi, statins na-eme nke ọma karịa mmerụ ahụ. Ekwesịrị ịhapụ ọgwụ a naanị ma ọ bụrụ na nsonaazụ ya anaghị anabata ya, ọ gaghị ekwe omume belata ya. A na-ekwubiga okwu ókè ihe ize ndụ nke nsogbu imeju. Echegbula onwe gị banyere ha ma ọ bụrụ na ị notụbiga mmanya ókè.
Ihe ngbanwe	Ọrịa imeju na-arụ ọrụ. Mmụba dị ukwuu na enzymes imeju bụ ALT na AST n'ime ọbara. Okpu akwara gbasara akwara siri ike - mwepu creatinine erughi 30 ml / min. Hypersensitivity na rosuvastatin ma ọ bụ ndị ochie nke mebere mbadamba. Na mba ndị na-asụ Russian, a na-ewere afọ iri na asatọ dị ka ihe mgbochi, ọ bụ ezie na mba ofesi, a na-edezi nkwadebe rosuvastatin maka ndị na-eto eto malite na 10 afọ.
Ime na inye nwa ara	Krestor, ọgwụ ndị ọzọ nke rosuvastatin na statins ndị ọzọ na - egbochi contraindicated n'oge ime. Womenmụ nwanyị nọ n'afọ ndụ ịmụ nwa ndị a na-ahụ maka akpụ ga-eji ọgwụ mgbochi ndị a pụrụ ịdabere na ha. Ọ bụrụ na ịtụrụ ime emeghị emebeghị, mgbe ahụ ị ga - eji ọgwụ were cholesterol kwusi ozugbo. Na nzụlite usoro ọgwụgwọ nke ị thisụ ọgwụ a, ị nweghị ike inye nwa ara.
Mkparịta ụka ọgwụ ọjọọ	Mbadamba nke Krestor na-enye mmekọrịta dị obere na ọgwụ ndị ọzọ na-adịghị mma karịa statins gara aga. Mana nsogbu ahụ ka dịgidere. Enwere ike inwe nsogbu ọgwụ, ọgwụ mgbochi ọrịa, ọgwụ mgbochi afọ ime, ndị na-eche ọbara, na ọtụtụ ọgwụ ndị ọzọ. Nke a nwere ike ibute nsonaazụ dị egwu - imeju akụrụ na arụ ọrụ akụrụ. Soro dọkịta gị kwurịta! Tupu ị chikọta ihe oyiyi ahụ, gwa dọkịta gị banyere ọgwụ niile, nri nri, na ọgwụ ị na-a .ụ.
Dodoụbiga ya ókè	Enweghị ọgwụgwọ a kapịrị ọnụ maka ịdoụbiga Krestor ókè. Ndị dọkịta na-enye ọgwụgwọ na usoro nkwado Symptomatic, na-enyocha ọrụ imeju na ogo nke ọrụ phosphokinase. Usoro ọgwụgwọ adịghị enye aka iwepu rosuvastatin n'ahụ.
Ntụziaka pụrụ iche	Na-amalite na-emeso gị na statins, na-agbaso usoro nri ma na-ebi ndụ dị mma. A na-atụ aro ka ileba anya na ọrụ akụrụ oge site na iji ọbara na mmamịrị. Ọ bụrụ na achọpụtara protein na mmamịrị ma ọ bụ itinye uche ya na-abawanye, gee ntị na dọkịta. Ọ bụrụ na enweghi homonụ thyroid, emela ọsọ ọsọ were buru akpụ, mana gwọọ hypothyroidism iji weghachi cholesterol dị ka ọ kwesiri. Krestor na ọgwụ ndị ọzọ nke rosuvastatin na-abawanye shuga n'ọbara n’ebe ndị ọrịa nwere ọrịa shuga na ọrịa kansa nọ.
Mpempe mwepụta	Mbadamba ihe eji etinye fim nke 10, 20 na 40 mg. N'ime blisters sitere na laminate aluminom ma ọ bụ foil, mbadamba 7 ma ọ bụ 14. N'ime mkpọ nke kaadiboodu, blisters 1, 2 ma ọ bụ 4.
Usoro na ọnọdụ nchekwa	Storechekwa na ọkọchị, na-echebe ya site na ìhè, ebe ahụ, ụmụaka adịghị ya, na-enweghị ogo 30 Celsius. Ndụ shelf bụ afọ 3.
Ngwakọta	Ihe na-arụ ọrụ bụ calcium rosuvastatin. Ndị pụrụ iche - lactose monohydrate, MCC, phosphate calcium, crospovidone, magnesium stearate. Ihe mgbo nke mbadamba osisi bu lactose monohydrate, hypromellose, triacetin (glycerol triacetate), titanium dioxide, iron iron dye oxide.

Ọtụtụ ndị ọrịa chọrọ iji dochie ọgwụ Krestor na ụfọdụ analog, karịa ọnụ ahịa, nwere otu ihe eji arụ ọrụ. Vidiyo dị n'okpuru ga - enyere gị aka. Lelee ya iji mee nhọrọ dị mma n'etiti ọtụtụ mbadamba rosuvastatin dị na ụlọ ahịa ọgwụ.

Crestor: nyocha

Na saịtị asụsụ Russian ị ga-ahụ ọtụtụ nyocha banyere Krestor ọgwụ. Mkpụrụ ọgwụ ndị a na-ewu ewu, n'agbanyeghị ọnụahịa ha dị elu. Mgbe ndị mmadụ na-ede nyocha banyere ọgwụ ndị ọzọ rosuvastatin (Mertenil, Roxer, Rosucard), ha na-eme mkpesa na nsonaazụ ha. Nyocha banyere ọgwụ Krestor ọgwụ jupụtara na mkpesa ezi uche dị na ya maka ọnụ ahịa ya dị elu. Ma ọ bụ ndị edemede ole na ole na-ekwupụta nsonaazụ ndị ọzọ. Ndị na-enye nkọwa na saịtị ahụike nwere obi ụtọ na ọgwụ rosuvastatin mbụ ahụ wedara cholesterol ha. Iwe ha bụ naanị n’ihi nnukwu ego a ga-akwụrịrị maka ya.

Ndị ọrịa kwenyesiri ike na ebe ọ bụ na ha na-ewere rosuvastatin ndị kasị dị ọnụ ala, ọ gaghị enwe mmetụta ndị na-adịghị mma ma ọ bụ na ha agaghị adị obere. Kama ịhọrọ ọgwụ Krestor, ịhọrọ analogues dị ọnụ ala - Mertenil, Roxer, Rosucard ma ọ bụ ndị ọzọ - ndị mmadụ na-echekwa ego. Agbanyeghị, ha kwenyesiri ike na n'ihi ịchekwa ego ha ga-enwetakwu nsogbu ndị ọzọ. Ọ bụ ezie na ọmụmụ ihe ndị na-achịkwa ọgwụ isi egosiwo na nke a abụghị eziokwu. Imirikiti nsonaazụ akụkụ nke mmadụ na-eme mkpesa banyere nyocha ha bụ site n'ọdịdị uche nke ndị ọrịa, karịa mmetụta ọjọọ nke ọgwụ ọjọọ.

Ihe ngosi maka ojiji

Fredrickon nke hypercholesterolemia nke mbụ (ụdị IIa, gụnyere ezinụlọ heterozygous hypercholesterolemia) ma ọ bụ hypercholesterolemia agwakọta (ụdị IIb) dị ka mgbakwunye na nri, mgbe nri na usoro ọgwụgwọ ndị ọzọ na-abụghị ọgwụ (dị ka mmega ahụ, ibu na-ezughị ezu),

ezinaụlọ hypercholesterolemia dị ka mgbakwunye nri na usoro ọgwụgwọ belata (dịka ọmụmaatụ, LDL-apheresis) ma ọ bụ n'ọnọdụ ebe ụdị ọgwụgwọ ahụ adịghị arụ ọrụ nke ọma.

hypertriglyceridemia (ụdị nke IV dịka Fredrickson) dị ka mgbakwunye na nri,

na-ebelata oganihu nke atherosclerosis, dika mgbakwunye na nri n’ime ndị ọrịa a gosipụtara ọgwụgwọ iji belata mkpokọta cholesterol na LDL-C,

mgbochi mbụ nke isi ọrịa obi (ọrịa strok, nkụchi obi, ịtụgharị ụbụrụ) na ndị okenye n’enweghi akara ngosipụta nke ọrịa obi, ma ya na nnukwu nsogbu nke mmepe ya (ihe karịrị afọ iri ise gbagoro maka ụmụ nwoke na afọ iri isii maka ụmụ nwanyị, ịba ụba nke itinye ume na C-reactive. protein (≥2 mg / l) n’ihu opekata mpe otu n’ime ihe ndị ọzọ dị ize ndụ, dị ka ọbara mgbali elu, mkpụmkpụ nke HDL-C, ị smokingụ sịga, akụkọ gbasara ezinụlọ n’oge mmalite nke ọrịa obi obi.

Mkparịta ụka nke ọgwụ Crestor na ndekọ nke nne

Maka ntụnyere, ụmụ agbọghọ gbasara ọgwụ mkpụrụ obere klaasị cholesterol Krestor 10 mg mbido Nke 28 - 1337 rubles, ihe na-arụ ọrụ bụ rosuvastatin, onye nrụpụta - AstraZeneca-IPR Pharmaceuticals Tevastor 10 mg mbido No. 30 - 471 rubles, ihe na-arụ ọrụ bụ rosuvastatin, onye na-emepụta - PHVMA TEVA / TEVA ozugbo emere ya. ebe anyị na-akwụfe ụgwọ maka ika ahụ. Data sitere na ụlọ ahịa ọgwụ & n.

. m gụọ ọtụtụ akwụkwọ na isiokwu a ugbu a. Rosehip dị mma ịkwanye na thermos n'abalị, enwere ọtụtụ vitamin, ọ bara uru maka obi na arịa. . na mbụ, ha dụrụ ọgwụ, anyị na-a drinkụ obe.

Anyị nwere Plavix (ugboro abụọ n'ụbọchị), Krestor, Kleksan (injections), echetaghị m ihe ndị ọzọ, ọ na-a drinksụkwa nju aka. Plavix na polycl. na Tatarstan ejiri Zilt dochie ya - na Moscow machibidoro ị toụ ihe nnọchi anya, yabụ ọ na-a everythingụ ihe niile dị na mbụ - anyị nwere otu ebe na mpaghara 20,000 rubles. Ọ na-apụ kwa ọnwa maka ọgwụ.

Were ọgwụ ole na ole Krestor na Tevastor, bụ ụzọ iji belata cholesterol ọbara na ndị ọrịa nwere atherosclerosis. Tevastor bụ ihe mepere emepe nke Krestor ma dabere na Rosuvastatin, Tevastor dị okpukpu atọ karịa nke dị ala karịa Krestor, mana o nwere akara. Lee ya na.

Cholesterol bụ ihe dị elu (ya mere, Krestor na-a )ụkwa), belata nrụgide karịa 100/60 ma ọ bụ 110/70, dị ka nke m. Agba nke mbu nke atherosclerosis n'ime ya. Omega manyere ị drinkụ otu ọnwa gara aga, na-a .ụ. Calcium d3 na-a nyụbiga mmanya ókè. Ana m eche, Krestor ya na Aspirin dị mma?

,Mụ agbọghọ, ọ dị mma na m hụrụ ntụnyere ndị a. Aga m edobe ya. Daalụ maka ozi bara uru. Nna m na-anara obe ma n’uzo obula na odi obere onu nye anyi. Jessica, ị maghị na enwere ike iji Tevastor mee ihe ugbu a na-enweghị ndenye ọgwụ dọkịta, naanị ọnụ ahịa ọnụahịa ka ama ama. Na mmetụta dị a afteraa mgbe etinyechara Tevastor bụ otu ihe ahụ p.

. Oy - nke a dị ezigbo mma. O yiri ka ọ nweghị ihe dị njọ na njikọta ọgwụ abụọ a. Ọ dịkarịa ala, otu ugboro enwere m ọgwụ atherosclerosis na vasilip na ọgwụ mgbu ọnụ. Ma ka m si ghọta ya, obe na vasilip sitere n’otu opera. Eziokwu, a didụghị m - vasilip abụghị ọgwụ ị nwere ike ịtụrụ ime :-)

Nrụpụta nke Tevastor bụ otu ihe ahụ Crestor. ka emechara, ọgwụ abụọ ahụ nwere rosuvastatin nwere arụ ọrụ, mana Anya kwesịrị iwere ya naanị dịka onye dọkịta gwara ya!

Ọ na-a aụ obe (tevastor). mgbochi mbụ nke isi ọrịa obi (ọrịa strok, nkụchi obi, ịtụgharị ụbụrụ) na ndị okenye n’enweghi akara ngosipụta nke ọrịa obi, ma ya na nnukwu nsogbu nke mmepe ya (ihe karịrị afọ iri ise gbagoro maka ụmụ nwoke na afọ iri isii maka ụmụ nwanyị, ịba ụba nke itinye ume na C-reactive. protein (≥2 mg / l) na ọnụnọ ma ọ dịkarịa ala otu n'ime ihe ndị ọzọ dị ize ndụ, dị ka ọbara mgbali elu, mkpụmkpụ nke HDL-C, ise anwụrụ, fam.

Adaghị m ọrịa. Ana m agụ akwụkwọ na ụgbụ, niile ahụ, ya fibrinogen dị elu, ọbụlagodi afọ. anyị niile nwere nsogbu vaskụla n’ime ezinụlọ. onye ọ bụla nwụrụ site na nke a, ma ọ bụ ọrịa kansa. n’adighi ike: (Echere m na anyị nwere ike ịgbakwunye Aspirin-cardio na Krestor? Ọ dịghị afụ ụfụ. Enweghị proromlasis na krestor. Ọ nwere cholesterol dị elu na mmalite atherosclerosis + ọ na-aokesụ sịga.

Ọgwụ Farmacology

Onye na - ahụ maka hypolipPs sitere na otu nke statins, onye na - egbochi HMG-CoA reductase. Dabere na ụkpụrụ ịsọ mpi ịkwa iko, mpekere statin na - ejikọ akụkụ ahụ Coenzyme A receptor ebe enzyme a na - etinye. Akụkụ ọzọ nke statin molecule na-egbochi ntụgharị nke hydroxymethylglutarate na mevalonate, ihe na-etiti na njikọ nke ụmụ irighiri cholesterol. Mgbochi ọrụ HMG-CoA reductase na-eduga n'usoro nke mmeghachi omume nke usoro, na-ebute mbelata ọdịnaya choralerol intracellular yana mmụba ụgwọ ọrụ nke ndị na-anabata LDL ma, ya mere, catabolism nke LDL cholesterol (Xc) na-akpata ike ngwa ngwa.

A na - ejikọta mmetụta hypolipPs nke statins na mbelata ọkwa nke cholesterol zuru oke n'ihi cholesterol LDL. Mbelata nke LDL bụ ihe dabere na nkwụchi ọnweghị akara, kama ọ dị mkpa.

Statins anaghị emetụta ọrụ nke lipoprotein na hepatic lipases, anaghị emetụta njikọ na catabolism nke ọdụdụ abụba n'efu, yabụ, mmetụta ha na ọkwa TG bụ nke abụọ na enweghị isi site na nsonaazụ ha bụ isi dị ala nke LDL-C dị ala. Obere mbelata ogo larịị TG n'oge ọgwụgwọ na anụ ahụ pụtara na ngosipụta nke ndị na-anabata ihe (apo E) ndị na-enweta hepatocytes metụtara catabolism nke STD, nke nwere ihe dịka 30% TG.

Na mgbakwunye na mmetụta mmetụ egbugbere ọnụ, statins nwere ezigbo mmetụta endothelial dysfunction (kpọmkwem akara nke atherosclerosis n'oge), na mgbidi vaskụla, steeti atheroma, melite akụrụngwa ọbara, nwere antioxidant, Njirimara antiproliferative.

A na-egosipụta mmetụta ọgwụgwọ ahụ n'ime izu 1. mgbe mmalite nke ọgwụgwọ na mgbe izu abụọ nke ọgwụgwọ gasịrị bụ 90% nke nsonaazụ kachasị, nke a na-arụpụta site n'izu anọ na mgbe nke ahụ gasịrị na-adịgide.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ C_max plasma rosuvastatin ruru n'ihe dị ka awa 5. Bioavailability dị ihe dịka 20%.

Rosuvastatin na-agbakọ na imeju. Ise_d - ihe dịka 134 lita Indmegide protein ndị dị na plasma (ọkachasị na albumin) bụ ihe dị ka 90%.

Biotransforms ka obere obere (ihe dị ka 10%), ịbụ onye na - abụghị mkpụrụ maka ihe na - anọpụ iche maka isoenzymes nke usoro cytochrome P₄₅₀. Isi isoenzyme tinyere aka na metabolism nke rosuvastatin bụ CYP2C9. Isoenzymes CYP2C19, CYP3A4 na CYP2D6 etinyechaghị aka na metabolism.

Ihe bụ isi metabolites nke rosuvastatin bụ N-dismethyl na lactone metabolites. N-dismethyl dị ihe dị ka 50% na-arụ ọrụ karịa rosuvastatin, metabolic lactone anaghị arụ ọrụ ọgwụ.

Ihe dị ka 90% nke ọgwụ rosuvastatin bụ ndị na-agbanweghi agbanwe na feces. Nke fọdụrụnụ na mmamịrị. Plasma T_1/2 - ihe dị ka awa 19 T_1/2 adịghị agbanwe site na ịba ụba dose. Ibepu onyonyo plasma dị ihe dị ka 50 l / h (ọnụọgụ nke mgbanwe 21.7%).

Dị ka ọ dị n'ihe banyere ndị ọzọ na-egbochi HMG-CoA-reductase, XC nke membrane na-etinye aka na mbido henante rosuvastatin, nke na-arụ ọrụ dị mkpa na mkpochapu hepatic rosuvastatin.

Ihe ngosi usoro nke rosuvastatin na-abawanye na oke na nha.

N'ime ndị ọrịa nwere nnukwu ọdịda gbasara akụrụ (QC niile

Analogs Crestor

Dakọtara dị ka egosi

Ọnụahịa ahụ sitere na 54 rubles. Ihe analogue dị ọnụ ala karịa 606 rubles

Dakọtara dị ka egosi

Ọnụahịa site na 324 rubles. Ihe analogue dị ọnụ ala site na 336 rubles

Dakọtara dị ka egosi

Ọnụahịa ahụ sitere na 345 rubles. Ihe analogue dị ọnụ ala site na 315 rubles

Dakọtara dị ka egosi

Ọnụahịa ahụ sitere na 369 rubles. Ihe analogue dị ọnụ ala site na 291 rubles

Dakọtara dị ka egosi

Ọnụahịa ahụ sitere na 418 rubles. Ihe analogue dị ọnụ ala site na 242 rubles

Dakọtara dị ka egosi

Ọnụahịa ahụ sitere na 438 rubles. Ihe analogue dị ọnụ ala site na 222 rubles

Dakọtara dị ka egosi

Ọnụahịa ahụ sitere na 604 rubles. Ihe analogue dị ọnụ ala site na 56 rubles

Dakọtara dị ka egosi

Ọnụahịa ahụ sitere na 737 rubles. Ihe analogue bu ezigbo ego na 77 rubles

Dakọtara dị ka egosi

Ọnụahịa ahụ sitere na 865 rubles. Ihe analog ahụ dị ọnụ karịa 205 rubles

Usoro onunu ogwu:

Mbadamba ụrọ nke ọ bụla nwere umi arụ ọrụ: rosuvastatin 10, 20 ma ọ bụ 40 mg n'ụdị calcium rosuvastatin.
Ndị e mere: lactose monohydrate 89.50 mg (maka onunu ogwu nke 10 mg), 179.00 (maka onunu ogwu nke 20 mg), 164.72 mg (maka onunu ogwu nke 40 mg), microcrystalline cellulose 29.82 mg (maka onunu ogwu nke 10 mg), 59.64 mg (maka onunu ogwu nke 20 mg), 54.92 mg (maka onodu ogwu nke 40 mg), calcium phosphate 10.90 mg (maka onunu ogwu nke 10 mg), 21.80 mg (maka onunu ogwu nke 20 mg), 20.00 mg (maka onunu ogwu 40 mg), crospovidone 7.50 mg (maka onunu ogwu nke 10 mg), 15.00 mg (maka onunu ogwu nke 20 mg), 15.00 mg (maka onunu ogwu nke 40 mg), magnesium stearate 1.88 mg (maka onunu ogwu nke 10 mg) 3.76 mg (maka onunu ogwu nke 20 mg), 3.76 mg (maka onunu ogwu nke 40 mg), shei mbadamba: lactose monohydrate 1.80 mg (maka onunu ogwu nke 10 mg), 3.60 mg (maka onodu ogwu nke 20 mg), 3.60 mg (maka onodu ogwu nke 40 mg), hypromellose 1.26 mg (maka onunu ogwu nke 10 mg), 2.52 mg (maka onunu ogwu nke 20 mg), 2.52 mg (maka onodu ogwu nke 40 mg), triacetin (glycerol triacetate) 0.36 mg (maka onunu ogwu nke 10 mg), 0.72 mg (maka onunu ogwu nke 20 mg), 0.72 mg (maka onunu ogwu nke 40 mg), titanium dioxide 1.06 mg (maka onunu ogwu nke 10 mg), 2.11 mg (maka onunu ogwu nke 20 mg), 2.11 mg (maka onunu ogwu nke 40 mg), iron dye oxide red 0.02 mg (maka onunu ogwu nke 10 mg), 0.05 mg (maka onodu ogwu nke 20 mg), 0.05 mg (maka onunu ogwu nke 40 mg).

Nkọwa

Mbadamba ụrọ 10 mg: okirikiri, mbadamba biconvex, nke etinyere na mpempe akwụkwọ ihe nkiri pink, kanyere “ZD4522 10” n'otu akụkụ.
Mbadamba 20 mg: mbadamba biconvex gbara okirikiri, nke eserese pink na-acha uhie uhie, kpụrụ na "ZD4522 20" n'otu akụkụ.
Mpempe 40 mg: oval, mbadamba biconvex, kpuchie ya na mpempe akwụkwọ ihe nkiri pink, kanyere “ZD4522” n'otu akụkụ yana 40 n'akụkụ nke ọzọ.

Ngwongwo ogwu

Usoro nke ime ihe
Rosuvastatin bụ ihe na - ahọrọ, na-egbochi asọmpi HMG-CoA reductase, enzyme nke na - agbanwe 3-hydroxy-3-methylglutaryl coenzyme A ka mevalonate, ihe na - achọ cholesterol. Ebumnuche bụ isi nke rosuvastatin bụ imeju, ebe a na-arụ njikọ nke cholesterol (cholesterol) na catabolism nke lipoproteins dị ala (LDL) dị ala.
Rosuvastatin na-abawanye ọnụ ọgụgụ nke ndị na - anabata LDL ndị na - anabata LDL na sel ahụ, na - eme ka nkwalite na catabolism nke LDL na - eme nke a, na - eduga na mgbochi nke mkpokọta lipoproteins dị ala (VLDL), si otú a belata ngụkọta nke LDL na VLDL.

Mlọ ọgwụ
Krestor ® na - ebelata oke mkpokọta nke LDL cholesterol (cholesterol-LDL), cholesterol zuru oke, triglycerides (TG), na - eme ka mkpoprotein cholesterol dị elu (HDL-C) dị elu, ma na - ebelata mkpụkọ nke apolipoprotein B (ApoV), non-HDL cholest -LVONP, TG-VLDLP ma nwekwuo mkpokọta apolipoprotein AI (ApoA-I) (lee tebụlụ nke 1 na nke 2), na-ebelata oke nke LDL-C / HDL-HDL, cholesterol / HDL-C na HDL-C / HDL-C na ApoB / ApoA-I ruru.
Mmetụta ọgwụgwọ na-etolite n'ime otu izu mgbe mmalite ọgwụgwọ na Krestor ®, mgbe izu abụọ nke ọgwụgwọ rutere 90% nke mmetụta kachasị.
Mmetụta ọgwụgwọ kachasị na-enweta site na izu nke 4 nke ọgwụgwọ ma ejiri ya na ọgwụ ahụ mgbe niile.

Isiokwu 1 . Mmetụta ịdabere na dose na ndị ọrịa nwere hypercholesterolemia bụ isi (ụdị IIa na IIb dịka Fredrickson) (nkezi mgbanwe mgbanwe pasent gbanwere ma e jiri ya tụnyere uru mbụ).

Dose	Gb nke ndị ọrịa	HS-LDL	Cholesterol zuru ezu	HS-HDL	TG	HS-abụghị HDL	ApoV	ApoA-I
Ebe	13	-7	-5	3	-3	-7	-3	0
10 mg	17	-52	-36	14	-10	-48	-42	4
20 mg	17	-55	-40	8	-23	-51	-46	5
40 mg	18	-63	-46	10	-28	-60	-54	0

Isiokwu 2 . Mmetụta ịdabere na dose na ndị ọrịa nwere hypertriglyceridemia (ụdị IIb na IV dị ka Fredrickson) (mgbanwe pasent pasent ma e jiri ya tụnyere uru mbụ).

Dose	Gb nke ndị ọrịa	TG	HS-LDL	Cholesterol zuru ezu	HS-HDL	HS-abụghị HDL	HS-VLDLP	TG-lponp
Ebe	26	1	5	1	-3	2	2	6
10 mg	23	-37	-45	-40	8	-49	-48	-39
20 mg	27	-37	-31	-34	22	-43	-49	-40
40 mg	25	-43	-43	-40	17	-51	-56	-48

Igwu arụmọrụ Krestor ® dị mma na ndị okenye nwere hypercholesterolemia nwere ma ọ bụ na-enweghị hypertriglyceridemia, agbanyeghị agbụrụ, okike ma ọ bụ afọ, gụnyere ndị ọrịa nwere ọrịa mellitus na familial hypercholesterolemia. Na 80% nke ndị ọrịa nwere ụdị IIa na IIb hypercholesterolemia dị ka Fredrickson (nkezi ịta LDL-C bụ ihe dị ka 4.8 mmol / L), mgbe ị na-a theụ ọgwụ ahụ na dose 10 mg, ịta LDL-C erughị 3 mmol / L.
N'ime ndị ọrịa nwere heterozygous familial hypercholesterolemia na-anata Krestor ® na ntinye nke 20-80 mg, a hụrụ mgbanwe dị mma nke profaịlụ anụ ahụ (ọmụmụ metụtara ndị ọrịa 435). Mgbe itichara gụrụ ọgwụ kwa ụbọchị nke 40 mg (izu iri na abụọ nke ọgwụgwọ), a na-achọpụta mbelata mgbanye nke LDL-C site na 53%. N'ime 33% nke ndị ọrịa, a na-enweta mkpo LDL-C nke erughị 3 mmol / L.
N'ime ndị ọrịa nwere hypercholesterolemia homozygous familial na-ewere Krestor ® na 20 mg na 40 mg, mbelata nkezi na mkpokọta LDL-C bụ 22%.
N'ime ndị ọrịa nwere hypertriglyceridemia nwere ntụpọ mbụ nke TG sitere na 273 ruo 817 mg / dl onye natara Krestor ® na ọgwụ nke 5 mg ruo 40 mg otu ugboro kwa izu maka izu isii, ọnụ ọgụgụ TG na plasma ọbara dị belatara nke ukwuu (lee okpokoro 2 )
A na-ahụta mgbakwunye mmetụta na fenofibrate n'ihe metụtara mkpokọta triglycerides yana nicotinic acid na usoro mkpolata egbugbere ọnụ n'ihe metụtara ịta nke HDL-C (leekwa mpaghara “Ntuziaka Pụrụ Iche”).
Na omumu ihe omumu METEOR, gbasara ndi oria 984 noo iri-ano n’ato rue iri-ano rue iri isii (154.5) na onodu ojoo nke oria Framingham erughi 10%), LDL cholesterol foduru nke 4.0 mmol / L (154.5) mg / dl) na subheccleical atherosclerosis (nke nyochaworo site na ọkpụrụkpụ carotid artery intima-media complex - TCIM) mụrụ mmetụta rosuvastatin na ọkpụrụkpụ nke ogige intima-media. Ndị ọrịa natara rosuvastatin na dose 40 mg / ụbọchị ma ọ bụ placebo ruo afọ 2.
Usoro ọgwụgwọ Rosuvastatin belatara nke ukwu na TCIM kachasị maka akụkụ 12 nke akwara carotid ma e jiri ya tụnyere placebo nwere ọdịiche nke -0.0145 mm / afọ 95% ntinye ntụkwasị obi site na -0.0196 ruo -0.0093, a naghị atụ aro p ® 40 mg. Ekwesịrị iji ọgwụ were 40 mg mee ihe na ndị ọrịa nwere hypercholesterolemia na nnukwu ihe ize ndụ nke ọrịa obi (CVD).
Nsonaazụ nke omumu ihe omumu nke JUPITER (Ezi uche maka iji ihe eji eme ihe maka mgbochi mbu: omumu ihe omumu na-enyocha rosuvastatin) na 17802 ndi oria gosiputara na rosuvastatin belatara ihe isi ike nke onodu ojoo (252 na otu placebo ma e jiri ya tụnyere 142 na rosuvastatin otu) (p. mgbe ọnwa isii mbụ nke ị theụ ọgwụ ahụ, enwere ọnụ ọgụgụ dị ịrịba ama nke ọnụego 48% gbakwunyere na nchịkọta, gụnyere ọnwụ site na ihe kpatara ọrịa obi, insulin. m na myocardial infarction (odachi ruru: 0,52, 95% obi ike nkeji 0,40-0,68, p ® na ụmụ n'okpuru afọ 18.

Ndị ọrịa nwere ọrịa imeju
Enweghị data ma ọ bụ ahụmịhe banyere iji ọgwụ ahụ eme ihe na ndị ọrịa nwere akara dị elu karịa 9 na ọkwa Child-Pugh (lee akụkụ "Pharmacodynamics" na "Ntuziaka Pụrụ Iche").

Usoro onunu ogwu na nhazi

N’ime ime, anaghị ata ma ọ bụ gwuo mkpụrụ osisi ahụ, loda ihe niile, jiri mmiri kwọọ ya. Enwere ike ịkọ ọgwụ a n'oge ọ bụla n'ụbọchị, n'agbanyeghị nri iri.
Tupu ịmalite ọgwụgwọ na Krestor ®, onye ọrịa kwesịrị ịmalite ịgbaso usoro nri hypocholesterolemic ma nọgide na-agbaso ya n'oge ọgwụgwọ. Ekwesịrị ịhọrọ dose nke ọgwụ ahụ n'otu n'otu dabere na ebumnuche nke ọgwụgwọ yana nzaghachi ọgwụgwọ maka ọgwụgwọ, na-eburu n'uche ugbu a na ebumnuche nke lipids.
Usoro akwadoro ịmalite maka ndị ọrịa malitere ị theụ ọgwụ, ma ọ bụ maka ndị ọrịa ebugharị na ị otherụ ọgwụ mgbochi ndị ọzọ HMG-CoA, kwesịrị ịbụ 5 ma ọ bụ 10 mg nke Krestor ® otu ugboro n'ụbọchị. Mgbe ị na-ahọrọ usoro ọgwụgwọ mbụ, mmadụ kwesịrị ibughari uche nke cholesterol ma chebara ihe ọghọm nke ọrịa obi ọgụ, ọ dịkwa mkpa ịtụle ihe ọghọm dị na nsonaazụ ọ bụla. Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye dose ahụ ka ukwuu ka izu anọ gachara (lee mpaghara “Pharmacodynamics”).
N'ihi mmepe ga - ekwe omume ị effectsụ nsogbu mgbe ị na - a ofụ ọgwụ 40 mg, ma e jiri ya tụnyere obere usoro ọgwụ ahụ (lee akụkụ “Side effects”), ịbawanye dose ahụ gaa na 40 mg mgbe ọgwụ mgbakwunye ahụ dị elu karịa usoro ọgwụgwọ akwadoro maka izu anọ. Enwere ike ịme ọgwụgwọ naanị na ndị ọrịa nwere nnukwu hypercholesterolemia na nnukwu ihe ize ndụ nke ọrịa obi (ọkachasị na ndị ọrịa nwere familial hypercholesterolemia) ndị na-enwetaghị nsonaazụ ha chọrọ ọgwụgwọ mgbe ị na-a takingụ ọgwụ 20 mg, oleekwa onye ga-eme ya? n'okpuru ọkachamara na-elekọta (lee. "Special Ntuziaka" ngalaba).
A na-atụ aro iji nlezianya nyochaa ndị ọrịa na-anara ọgwụ ahụ na ọgwụ 40 mg.
A naghị atụ aro ka a sụọ ọgwụ were 40 mg maka ndị ọrịa na-agabeghị dọkịta.
Ka izu 2-4 gachara eji agwọ ọrịa na / ma ọ bụ mmụba na dose nke nkwadebe Krestor,, ileba anya na metabolism dị mkpa (mmezi dose dị mkpa ma ọ bụrụ na ọ dị mkpa).

Ndị okenye na-arịa ọrịa
Dose ukpụhọde adịghị.

Ọrịa enweghị akụrụ
N'ime ndị ọrịa nwere nsogbu gbasara akụrụ dị obere ma ọ bụ na-adịghị agafe agafe, ọ dịghị mkpa ịgbanwe ndozi dose. N'ime ndị ọrịa nwere nnukwu akụrụ oke (CC erughi 30 ml / min.), Ọgwụ Krestor ® na-egbochi ọgwụ.
Eji ogwu a mee ihe na pacenti iri anọ na iri (40 mg) na ogwu n’onye ndi n’enwe nsogbu igba nkpuru-akwara aru (CC erughi 30-60 ml / min.) (Lee mpaghara “Ntuziaka puru iche” na “Pharmacodynamics”). Maka ndị ọrịa nwere ọrụ mkpali na-adịghị ala ala, a na-atụ aro izizi nke 5 mg.

Ndị ọrịa nwere ọrịa imeju
Krestor ® ka contraindicated na ndị ọrịa nwere ọrịa imeju na usoro ọrụ (lee mpaghara "Contraindications").

Onu ogugu ndi puru iche. Agbụrụ agbụrụ
Mgbe ị na-amụ usoro ọgwụ ọgwụ ọgwụ rosuvastatin na ndị ọrịa nke agbụrụ dị iche iche, mmụba nke usoro nke rosuvastatin n'etiti ndị Japan na ndị China (hụrụ mpaghara "Ntuziaka Pụrụ Iche"). Ekwesiri iburu n'uche eziokwu a mgbe ị na-ede akwụkwọ Krestor ® maka ndị ọrịa a. Mgbe ị na-edepụta usoro onunu ogwu nke 10 na 20 mg, usoro ọgwụgwọ akwadoro maka ndị ọrịa nke agbụrụ Mongoloid bụ 5 mg. Nlekọta ọgwụ maka ị ofụ ọgwụ ọgwụ dị 40 mg maka ndị ọrịa agbụrụ Mongoloid (lee mpaghara "Contraindications").

Polymorphism mkpụrụ ndụ ihe nketa
Ndị na-ebugharị ụdị genotypes SLC01B1 (OATP1B1) c.521CC na ABCG2 (BCRP) c.421AA gosipụtara mmụba na mkpughe (AUC) na rosuvastatin ma e jiri ya tụnyere ndị na-eburu genotypes SLC01B1 c.521TT na ABCG2 c.421CC. Maka ndị ọrịa na-ebu genotypes c.521CC ma ọ bụ c.421AA, ọgwụ a tụrụ aro ka ukwuu nke Crestor ® bụ 20 mg otu ugboro kwa ụbọchị (lee akụkụ "Pharmacokinetics", "Ntuziaka Pụrụ Iche") na "Mmekọrịta na ọgwụ ndị ọzọ na ụdị mmekọrịta ọgwụ ndị ọzọ" )

Ndị ọrịa Myopathy-prone
Nlekọta ọgwụ a na-a aụ ọgwụ nke 40 mg na ndị ọrịa nwere ihe ndị nwere ike igosipụta ihe ga - eduga na mmepe nke myopathy (lee mpaghara "Contraindications"). Mgbe ị na-edepụta usoro onunu ogwu nke 10 na 20 mg, usoro ọgwụgwọ akwadoro maka ìgwè ndị ọrịa a bụ 5 mg (Lee akụkụ "Contraindications")

Usoro ọgwụgwọ na-ekwekọrịta
Rosuvastatin na - ejikọ nchekwa protein dị iche iche (ọkachasị, OATP1B1 na BCRP). Mgbe ejikọtara ya na Krestor ®, yana ọgwụ (dịka cyclosporine, ụfọdụ nje HIV nchebe, gụnyere nchikota ritonavir na atazanavir, lopinavir na / ma ọ bụ tipranavir), nke na-abawanye ịba ụba nke rosuvastatin na plasma n'ihi mmekorita ya na protein nchebe, ihe ize ndụ nke myopathy (gụnyere myopathy (gụnyere gụnyere myopathy) rhabdomyolysis (lee akụkụ "ntuziaka pụrụ iche" na "Mmekọrịta na ọgwụ ndị ọzọ na ụdị mmekọrịta ọgwụ ndị ọzọ"). Youkwesịrị ịgụ ntuziaka maka iji ọgwụ ndị a tupu oge atọrọ na njikọta ọgwụ Krestor ®. N'ụdị ndị a, ịkwesịrị ịtụle ohere nke ịkọwa usoro ọgwụgwọ ọzọ ma ọ bụ ịkwụsịtụ iji ọgwụ Krestor temporarily oge ụfọdụ. Ọ bụrụ na iji ọgwụ ndị dị n'elu dị mkpa, ịkwesịrị ịtụle nha nke uru na ihe ọghọm nke ọgwụ nkwekọ na ọgwụ Crestor and ma chee ohere iji belata ọgwụ ya (lee mpaghara “Mmekọrịta na ọgwụ ndị ọzọ na ụdị mmekọrịta ọgwụ ndị ọzọ”).

Mmetụta akụkụ

Nsonaazụ ndị hụrụ mgbe ị na-a theụ ọgwụ Krestor ® na-adịkarị nwayọ ma na-ala n'onwe ha. Dịka ọ dị na ndị ọzọ na-egbochi HMG-COL, ndị na - egbochi ihe ndị ọzọ na - emetụta ihe ndị ọzọ na - ebute mmetụta ndị ọ na - erite bụkarịrị.
E gosipụtara ọnọdụ nke ihe ojoo dị ka ndị a:
A na-ahụkarị (> 1/100, 1/1000, 1/10000, ®, proteinuria) A na-ahụ mgbanwe mgbanwe nke protein na mmamịrị (site na anọghị ya ma ọ bụ ọnụọgụ abụọ ++ ma ọ bụ karịa) na-erughị 1% nke ndị ọrịa na-anata 10-20 mg ọgwụ ahụ, na ihe dị ka 3% nke ndị ọrịa na-anata 40 mg nke ọgwụ.
A hụrụ ntakịrị mgbanwe na ọnụọgụ protein na mmamịrị mgbe ị na-a aụ ọgwụ 20 mg. N'ọtụtụ oge, proteinuria na-ebelata ma ọ bụ na-apụ n'anya n'oge ọgwụgwọ ma ọ pụtaghị na ọrịa ma ọ bụ ọrịa akụrụ na-aga n'ihu.
Site na usoro akwara
Mgbe ị na-a Kụ ọgwụ Krestor ® na usoro onunu ogwu ọ bụla, na ọkachasị mgbe ị na-a doụ ọgwụ ole gabigara 20 mg, a kọpụtara mmetụta ndị a na sistemụ akwara: myalgia, myopathy (gụnyere myositis), n'ọnọdụ ndị a na-adịghị ahụkebe, rhabdomyolysis na ma ọ bụ na-enweghị nnukwu gbasara akụrụ ọdịda. ya.
A na-achọpụta mmụba dabere na ọrụ nke creatine phosphokinase (CPK) na ọnụ ọgụgụ dị nta nke ndị ọrịa na-ewere rosuvastatin. N'ọtụtụ oge, ọ dị nro, asymptomatic na nwa oge. N'ihe banyere ọrụ ịrị elu nke CPK (ihe karịrị ugboro 5 ma e jiri ya tụnyere oke nke nkịtị), a ga-akwụsịtụrụ ọgwụgwọ (lee akụkụ "Ntuziaka Pụrụ Iche").
Site na imeju
Mgbe ị na-eji rosuvastatin, a na-achọpụta mmụba dabere na ọrụ “mmịnye” transminates n'ọtụtụ ndị ọrịa. N'ọtụtụ oge, ọ dị obere, asymptomatic na nwa oge.
Ihe ngosi ulo oru
Mgbe ị na-eji ọgwụ Krestor ®, achọpụtara mgbanwe ndị a na plọgum lab: a na-abawanye na mkpokọta glucose, bilirubin, ọrụ gamma-glutamyl transpeptidase, alkaline phosphatase, na dysfunction nke thyroid gland.

Ngwa ahia mgbere
A na-akọpụta mmetụta ndị ọzọ na-esote na nzaghachi azụmaahịa nke Krestor ®:
Site na usoro hematopoietic
Oge ekwesighi: thrombocytopenia
Site na ngwe nri
O siri ike: jaundice, ịba ọcha n'anya
Ikebịghike: mmụba nke “transponates” imeju
Oge a na-amaghị ama: ọnya afọ
Site na usoro akwara
Dịkarịsịrị iche: arthralgia
Achọpụtaghị ugboro: immuno-mediated necrotizing myopathy
Site na sistemụ ụjọ
Ọ dị ụkọ: mfu na ebe nchekwa
Oge a na-ejighị n'aka: neuropathy akụkụ
Site na sistem iku ume
Achọghị ugboro ole: ụkwara, ura ume
Site na usoro urinary
O siri ike: hematuria
N'akụkụ nke anụ ahụ na abụba subcutaneous
Uzo akukoputaghi: oria Stevens-Johnson
Site na usoro ọmụmụ na gland mammary
Achọghị ugboro ole: gynecomastia
Ndị ọzọ
Achọghị ugboro ole: edema akụkụ

Mgbe ị na-eji ụfọdụ arụ ọrụ, a na-akọpụta mmetụta ndị ọzọ:
ịda mba, ọgba aghara ụra, gụnyere ehighị ụra nke ọma na nro “ụra abalị”, agụụ mmekọahụ, hyperglycemia, ịbawanye ụba nke hemoglobin glycosylated.
Ekpesarala ihe dị iche iche gbasara ọrịa ngụgụ dị iche iche, ọkachasị na iji ọgwụ ogologo oge (lee mpaghara “Ntụziaka pụrụ iche”).

Dodoụbiga ya ókè

Site na nhazi nke oge a ọtụtụ ọgwụ kwa ụbọchị, usoro ọgwụ ọgwụ nke rosuvastatin anaghị agbanwe.
Enweghị ọgwụgwọ a kapịrị ọnụ maka ị ofụ ọgwụ rosuvastatin. N'ihe banyere ịdoụbiga mmanya ókè, a na-atụ aro ka ọ rụọ ọrụ Symptomatic na usoro iji na-arụ ọrụ nke akụkụ ahụ na sistem dị mkpa. Nyochaa ọrụ nke imeju yana ọkwa CPK dị mkpa. Usoro ọgwụgwọ a na-ahụkarị dị mma ga-adị irè.

Mmekọrịta na ọgwụ ndị ọzọ na ụdị mmekọrịta ọgwụ ndị ọzọ

Nsonaazụ ojiji nke ọgwụ ọgwụ ndị ọzọ na rosuvastatin
Ndị na-egbochi protein na-ebugharị: rosuvastatin na-ejikọ ụfọdụ protein nchebe njem, ọkachasị, OATP1B1 na BCRP. Concomụkọta ọgwụ ndị na - egbochi ihe nchebe na - ebugharị protein ndị a nwere ike ibikọ n'ọbara plasuma nke rosuvastatin yana ohere ị nwere nke myopathy (lee okpokoro 3 na ngalaba “Dozọ na nchịkwa” na “Ntụziaka Pụrụ Iche”).
Cyclosporin: n'iji rosuvastatin na cyclosporine n'otu oge, AUC nke rosuvastatin nọ nkezi nke asaa karịa nke a hụrụ na ndị ọrụ afọ ofufo siri ike (lee okpokoro 3). Ọdịghị emetụta mkpụkọ plasma nke cyclosporine. Krestor ® ka contraindicated na ndị ọrịa na-ewere cyclosporine (lee mpaghara "Contraindications").
Nje virus nke na - egbochi immunodeficiency ብቃት (HIV): ọ bụ ezie na amabeghị usoro a ga-esi na-emekọ ihe ọnụ, nhazi nke ndị na-egbochi nje HIV na-egbochi nchebe nwere ike ibute mmụba dị ukwuu na mgbasa ozi nke rosuvastatin (lee table 3).
Ọmụmụ ọgwụ pharmacokinetic maka ojiji nke 20 mg nke rosuvastatip n'otu oge yana nkwadebe njikọta nke nwere mgbochi nje HIV abụọ (400 mg nke lopinavir / 100 mg nke ritonavir) na ndị ọrụ afọ ofufo dị mma dugara n'ihe dị ka okpukpu abụọ na okpukpu ise na AUC (0-24) na Cmax nke rosuvastatin, n'otu n'otu. Ya mere, akwadoghi ka imeghari rosuvastatin na nje mgbochi nchebe nke HIV (lee akụkụ "Usoro Ọgwụ na Nchịkwa", "Ntuziaka Pụrụ Iche", tebụl 3).
Gemfibrozil na ọgwụ ndị ọzọ na-eweta mmachi: jikọtara rosuvastatin na gemfibrozil na-eduga na mmụba okpukpu abụọ nke rosuvastatin kachasị na plasma ọbara na AUC nke rosuvastatin (lee akụkụ "ntuziaka pụrụ iche"). Dabere na data gbasara mmekorita ndị akọwapụtara, anaghị atụ anya mmekọrịta dị n'etiti ọgwụ na fenofibrate, enwere ike ịmekọrịta ọgwụ ọgwụ.
Gemfibrozil, fenofibrate, fibrates ndị ọzọ, na usoro nke nicotinic acid nwere nsogbu nke mịpathy mụbara ma ọ bụrụ na ejikọtara ya na HMG-CoA reductase inhibitors, ikekwe n'ihi eziokwu ahụ na ha nwere ike ibute myopathy mgbe ejiri ya na monotherapy (lee akụkụ "Ntuziaka Pụrụ Iche") . Mgbe ị na-a theụ ọgwụ ahụ na gemfibrozil, fibrates, nicotinic acid na doses lipid (karịa 1 g / ụbọchị), a na-atụ aro ndị ọrịa ị nweta ọgwụ mbụ 5 mg, a na-egbochi ọgwụ 40 mg na njikọ ya na fibrates (lee akụkụ "Contraindications", ") Usoro ọgwụgwọ na nhazi "," Ntụziaka pụrụ iche ").
Ezetimibe: n'otu oge nke ọgwụ Krestor ® na dose nke 10 mg na ezetimibe na dose nke 10 mg yana mgbakwunye na AUC nke rosuvastatin na ndị ọrịa nwere hypercholesterolemia (lee okpokoro 3). Ọ gaghị ekwe omume iwepu ohere dị ukwuu nke nsonaazụ dị iche iche n'ihi mmekọrịta mmekọrịta ọgwụ na Krestor ® na ezetimibe.
Antacids: n'otu oge eji rosuvastatin na mgbochi nke antacids nwere magnesium na aluminom hydroxide, na-eduga na mbelata plasuma nke rosuvastatin ihe dị ka 50%. Agaghị ekwupụta mmetụta a ma ọ bụrụ na ejiri antacids awa 2 awa mgbe ị roụsịrị rosuvastatin. Emebeghị ka amuta ihe banyere ulo ogwu a.
Erythromycin: n'otu oge eji rosuvastatin na erythromycin na-eduga na mbelata AUC nke rosuvastatin site na 20% na Cmax nke rosuvastatin site na 30%. Mkparịta ụka dị otú a nwere ike ịbawanye ụba n'ihi mgbatị nke eriri afọ nke kpatara erythromycin.
Cytochrome P450 Isofermeitis: nsonaazụ nke vivo na nyocha vitro gosipụtara na rosuvastatin abụghị onye na-egbochi ma ọ bụ onye na-ekepụta isoenzymes nke cytochrome P450. Na mgbakwunye, rosuvastatin bụ mkpụrụ na-adịghị ike maka isoenzymes ndị a. Ya mere, mmekorita nke rosuvastatin na ọgwụ ndị ọzọ na ọkwa metabolic metụtara cytochrome P450 isoenzymes anaghị atụ anya.
Enweghi mmekorita di egwu nke rosuvastatin na fluconazole (onye na-egbochi isoenzymes CYP2C9 na CYP3A4) na ketoconazole (onye na-egbochi isoenzymes CYP2A6 na CYP3A4).
Fusidic acid: Ọmụmụ ihe iji mụọ mmekọrịta nke rosuvastatin na fusidic acid emebeghị. Dika odi na onyunyo ndi ozo, anabatachara banyere nzuko ire ahia nke rhabdomyolysis na mmekorita nke rosuvastatin na fusidic acid. Ọ dị mkpa iji nlezianya nyochaa ndị ọrịa. Ọ bụrụ na ọ dị mkpa, nkwụsị nke rosuvastatin nwa oge ga-ekwe omume.

Mmekorita ya na ogwu nke choro ndozi nke rosuvastatin (lee okpokoro 3)
Ọ kwesiri idozigharị ọgwụ nke Krestor ® ma ọ bụrụ na ọ dị mkpa, ojiji ya na ọgwụ ndị na-abawanye ikpughe rosuvastatin. Youkwesịrị ịgụ ntuziaka maka iji ọgwụ ndị a tupu oge atọrọ na njikọta ọgwụ Krestor ®. Ọ bụrụ na-atụ anya ikpughe ugboro abụọ ma ọ bụ karịa, nnwale mbụ nke nkwadebe Crestor ® kwesịrị ịbụ 5 mg otu ugboro kwa ụbọchị. Okacha nke Krestor ® kwa nke ekwesiri idozigharị ka ndagide anya nke rosuvastatin ghara ịgabiga nke ahụ maka ntụtụ 40 mg ewere na enweghị nchịkwa oge nke ọgwụ na-emekọrịta na rosuvastatin. Dịka ọmụmaatụ, ọgwụ kachasị elu nke ọgwụ Crestor ® nwere otu oge na gemfibrozil bụ 20 mg (mmụba na mkpughe site na oge 1.9), yana ritonavir / atazanavir - 10 mg (mmụba na mkpughe bụ 3.1 ugboro).

Isiokwu 3 . Mmetụta ọgwụgwọ concoitant na mkpughe na rosuvastatin (AUC, egosiri data na-agbada) - nsonaazụ nke nnwale ụlọ ọgwụ bipụtara.

Ọnọdụ metụtara usoro ọgwụgwọ	Ọnọdụ nnabata rosuvastatin	Gbanwee AUC rosuvastatin
Cycloporin 75-200 mg Ugboro abụọ n'ụbọchị., 6 ọnwa.	10 mg 1 oge kwa ụbọchị., 10 ụbọchị	Mmụba 7.1x
Atazanavir 300 mg / ritonavir 100 mg 1 oge kwa ụbọchị., 8 ụbọchị	10 mg otu dose	Mmụba 3.1x
Simeprevir 152 mg 1 oge kwa ụbọchị., 7 ụbọchị	10 mg otu dose	Mmụba 2.8x
Lopinavir 400 mg / ritonavir 100 mg 2 ugboro n'ụbọchị., 17 ụbọchị	20 mg 1 oge kwa ụbọchị., 7 ụbọchị	Oge 2.1 na-abawanye
Clopidogrel 300 mg (na-akwụ ụgwọ dose) mgbe ahụ 75 mg mgbe awa 24 gachara	20 mg otu dose	Mmụba 2x
Gemfibrozil 600 mg Ugboro abụọ n'ụbọchị., 7 ụbọchị	80 mg otu dose	Mmụba 1.9x
Eltrombopag 75 mg 1 oge kwa ụbọchị. 10 ikp	10 mg otu dose	Mmụba 1.6x
Darunavir 600 mg / ritonavir 100 mg Ugboro abụọ n'ụbọchị., 7 ụbọchị	10 mg 1 oge kwa ụbọchị., 7 ụbọchị	Oge 1.5 na-abawanye
Tipranavir 500 mg / ritonavir 200 mg Ugboro abụọ n'ụbọchị., 11 ụbọchị	10 mg otu dose	Oge 1.4 na-abawanye
Dronedarop 400 mg Ugboro abụọ n'ụbọchị.	Enweghị data	Oge 1.4 na-abawanye
Itraconazole 200 mg 1 oge kwa ụbọchị., 5 ụbọchị	10 mg ma ọ bụ 80 mg otu ugboro	Oge 1.4 na-abawanye
Ezetimibe 10 mg 1 oge kwa ụbọchị., 14 ụbọchị	10 mg otu ugboro kwa ụbọchị, ụbọchị iri na anọ	Oge 1.2 na-abawanye
Fosamprenavir 700 mg / ritonavir 100 mg Ugboro abụọ n'ụbọchị., 8 ụbọchị	10 mg otu dose	Enweghị mgbanwe
Aleglitazar 0.3 mg. 7 ikp	40 mg, 7 ụbọchị	Enweghị mgbanwe
Silymarin 140 mg 3 ugboro n'ụbọchị. 5 ikp	10 mg otu dose	Enweghị mgbanwe
Fenofibrate 67 mg 3 ugboro n'ụbọchị., 7 ụbọchị	10 mg, 7 ụbọchị	Enweghị mgbanwe
Rifampin 450 mg Otu ugboro n'ụbọchị. 7 ikp	20 mg otu dose	Enweghị mgbanwe
Ketoconazole 200 mg Ugboro abụọ n'ụbọchị., 7 ụbọchị	80 mg otu dose	Enweghị mgbanwe
Fluconazole 200 mg 1 oge kwa ụbọchị., 11 ụbọchị	80 mg otu dose	Enweghị mgbanwe
Erythromycin 500 mg 4 ugboro n'ụbọchị., 7 ụbọchị	80 mg otu dose	Mbelata 28%
Baikalin 50 mg 3 ugboro n'ụbọchị., 14 ụbọchị	20 mg otu dose	Mbelata 47%

Nsonaazụ nke rosuvastatin na ọgwụ ndị ọzọ
Vitamin K Antagonists: mmalite nke usoro ọgwụgwọ rosuvastatin ma ọ bụ mmụba nke dose na ndị ọrịa na-anata otu vitamin K antagonists (wdg. warfarin) nwere ike ibute mmụba na International Normalized Mmekọrịta (MHO). Drawepu rosuvastatin ma ọ bụ mbelata oke nke ọgwụ nwere ike iduga MHO mbelata. N'ụdị ndị ahụ, a na-atụ aro njikwa MHO.
Ogwu ogwu mgbochi ogwu / holomon nke ogwu: n'otu oge eji rosuvastatin na ọgwụ mgbochi ọnụ na-eme ka AUC nke ethinyl estradiol na AUC nke norgestrel dị 26% na 34%, n'otu n'otu. Ekwesịrị iburu ụdị mgbakwunye plasma a n'uche mgbe ị na-ahọrọ ọgwụ mgbochi ọgwụ a ga-aralụ.
Ihe omuma nke Pharmacokinetic maka ojiji nke ọgwụ Krestor ® na usoro ọgwụgwọ homonụ na-anọghị ya, yabụ, agaghị enwe ike ịgụnye nsonaazụ otu a na iji njikọ a. Agbanyeghị, ejikọtara ngwakọta a n'ọtụtụ oge ule ụlọ ọgwụ yana ndị ọrịa nabatara ya nke ọma.
Ọgwụ ndị ọzọ: Enweghị mmekọrịta dị n'etiti rosuvastatin na digoxin na-atụ anya.

Ntụziaka pụrụ iche

Mmetụta ntaramahụhụ
N'ime ndị ọrịa natara Krestor ® nke ukwuu (ọkachasị 40 mg), a hụrụ protein tubular proteinuria, nke ka n'ọtụtụ oge. Proteindị proteinuria ahụ egosighi ọrịa akụrụ nnukwu ma ọ bụ ọrịa ọrịa akụrụ. N'ime ndị ọrịa na-a theụ ọgwụ ahụ na ọgwụ 40 mg, a na-atụ aro ka nyochaa ndị na-egosi ọrụ akụrụ mgbe ọgwụgwọ.
Site na usoro akwara
Mgbe ị na-a Kụ ọgwụ Krestor ® na usoro onunu ogwu ọ bụla, na ọkachasị mgbe ị na-a doụ ọgwụ ọ bụla karịa 20 mg, a kọpụtara mmetụta ndị a na sistemụ akwara: myalgia, myopathy, n'ọnọdụ ndị a na-adịghị ahụkebe, rhabdomyolysis.
Mkpebi nke phosphokinase
Ekwesighi ime mkpebi nke CPK mgbe mgbatị ahụ siri ike ma ọ bụ ọ bụrụ na enwere ihe ndị ọzọ enwere ike ịme ka mmụba nke CPK, nke nwere ike ibute nkọwa na-ezighi ezi banyere nsonaazụ ahụ. Ọ bụrụ n ’ọkwa mbụ nke CPK na-abawanye ụba (ugboro ise karịa elu nke ụkpụrụ a), ekwesịrị ime ya ugboro ugboro ka ụbọchị nke iri asaa gachara. Agaghị ịmalite usoro ọgwụgwọ ma ọ bụrụ na nnwale ọzọ na-akwado ọkwa CK (ihe kariri ugboro ise karịa ogo dị elu nke nkịtị).
Tupu ịmalite usoro ọgwụgwọ
Mgbe ị na-edekọ Krestor ®, yana mgbe ị na-ede ọgwụ ndị ọzọ na-egbochi HMG-CoA reductase, ekwesịrị iji nlezianya gosipụta ndị ọrịa nwere ihe ndị dị ize ndụ maka myopathy / rhabdomyolysis (lee akụkụ "Nkpachara anya"), ọ dị mkpa ịtụle oke ihe ọghọm na uru omume ọgwụgwọ na nyocha ahụike.
N'oge ọgwụgwọ
Gwa onye ọrịa banyere mkpa ọ dị ịgwa dọkịta ozugbo ozugbo banyere nsogbu mgbu mgbu, ike ọgwụgwụ ma ọ bụ ịkpa oke, ọkachasị yana ịba na ahụ ọkụ. N'ime ndị ọrịa dị otú ahụ, a ga-ekpebi ọkwa nke CPK. Ekwesịrị ịkwụsị usoro ọgwụgwọ ma ọ bụrụ na ọnụego CPK dị elu (karịa ugboro ise ma e jiri ya tụnyere oke nke ụkpụrụ ahụ) ma ọ bụ ọ bụrụ na-egosi nrịba ama nke akwara ma mee ka ahụ erughị ala kwa ụbọchị (ọbụlagodi na ọkwa CPK dị okpukpu ise karịa nke elu. oke nke iwu). Ọ bụrụ na ihe mgbaàmà ahụ apụọ na ọkwa CPK laghachi na nkịtị, ekwesịrị ịtụleghachi iji kọwaa ọgwụ Krestor ® ma ọ bụ ndị ọzọ HMG-CoA reductase inhibitors na obere usoro site na iji nlezianya nyochaa onye ọrịa.
Usoro nlekọta nke CPK na-enweghị mgbaàmà enweghị isi.
A na-ahụkarị ikpe ikpe na-adịghị ala ala nke na-egbochi myopathy na ngosipụta nke ụlọ ọgwụ n'ụdị adịghị ike nke proximal muscle na mmụba nke ọkwa CPK n'ọbara ọbara n'oge ọgwụgwọ ma ọ bụ mgbe a na-ewere statins, gụnyere rosuvastatin. Ọmụmụ ihe ndị ọzọ gbasara akwara na akwara, ọmụmụ serological, yana ọgwụ immunosuppressive nwere ike ịchọ.
Enweghị akara nke mmụba ọ bụla na akwara ọkpụkpụ mgbe ị na-ewere Krestor ® na ọgwụgwọ concomitant. Agbanyeghị, mmụba na myositis na myopathy na ndị ọrịa na-ewere ndị ọzọ inhibitors, HMG-CoA reductase na njikọ fibric acid, gụnyere gemfibrozil, cyclosporin, nicotinic acid, antifungal antifungal, antiase inhibitors na ọgwụ nje macrolide. Gemfibrozil na-abawanye ohere nke myopathy mgbe ejikọtara ya na ụfọdụ ndị na-egbochi Htr-CoA reductase inhibitors. Yabụ, akwadoghị ịmechi ọgwụ nke Krestor ® na gemfibrozil n'otu oge. A ga-eji nlezianya tụọ oke ihe egwu dị na uru ịba uru mgbe ị na-eji nkwadebe Crestor with yana fibrates ma ọ bụ na - belata nicotinic acid. A na-emegide ọgwụ Krestor ® na dose 40 mg yana fibrates. (lee akụkụ "Mmekọrịta na ọgwụ ndị ọzọ na ụdị mmekọrịta ọgwụ ndị ọzọ", "Contraindications").
Izu iri anọ na anọ mgbe mmalite nke ọgwụgwọ na / ma ọ bụ mmụba na dose nke nkwadebe Krestor ®, nlebara anya metabolism dị mkpa (idozi dose dị mkpa ma ọ bụrụ na ọ dị mkpa).
Imeju
A na-atụ aro ikpebi ihe ndị na-egosi ọrụ imeju tupu ịmalite ọgwụgwọ yana ọnwa atọ ka mmalite ọgwụgwọ. A ga-akwụsị iji ojiji nke ọgwụ Krestor ® ma ọ bụ belata ọgwụ a ga-ebelata ma ọ bụrụ na ọkwa nke ọrụ transaminase na ọbara ọgbụgba ahụ dị okpukpu atọ karịa oke nke kwesịrị.
N'ime ndị ọrịa nwere hypercholesterolemia n'ihi hypothyroidism ma ọ bụ ọrịa nephrotic, a ga-ebu ụzọ gwọọ ọrịa ndị na-akpata ọrịa tupu ọgwụgwọ Crestor ®.
Onu ogugu ndi puru iche. Agbụrụ agbụrụ
N'ime usoro ọmụmụ ọgwụ pharmacookinetic n'etiti ndị ọrịa China na ndị Japan, a chọpụtara mmụba nke usoro nke rosuvastatin ma e jiri ya gosipụta ihe ngosi ndị enwetara n'etiti ndị ọrịa Europe (lee akụkụ "Usoro Ọgwụ na Nchịkwa" na "Pharmacokinetics").
Na-egbochi ndị na-egbochi gị
Agaghị akwado ikpokọta ọgwụ a yana ndị na - egbochi ndị na - egbochi ya (lee mpaghara "Mmekọrịta na ọgwụ ndị ọzọ yana ụdị mmekọrịta ndị ọzọ").
Lactose
Ekwesighi iji ọgwụ a mee ihe na ndị ọrịa nwere ụkọ lactase, enweghị ndidi galactose na glucose-galactose malabsorption.
Ọrịa ngụgụ
Mgbe ị na-eji ihe ụfọdụ akpụrụ akpụ, ọ kachasị, ogologo oge, kọọrọ ndị dịpụrụ adịpụ nke ọrịa ngụgụ. Ihe ngosiputa oria a nwere ike itinye mkpirisi iku ume, ukwara nke n’adighi eme, yana odi mma n’adighi ike (adighi ike, ibu na ahu oku). Ọ bụrụ na a na-enyo enyo ọrịa ọrịa ngụgụ, ekwesịrị ịkwụsị usoro ọgwụgwọ statin.
Ọrịa shuga 2dị 2
N'ime ndị ọrịa nwere mgbanye glucose nke 5.6 ruo 6.9 mmol / L, a na-ejikọ ọgwụgwọ Crestor ® na ohere dị ukwuu nke ọrịa shuga 2.

Mmetụta ikike ịkwọ ụgbọala na usoro ndị ọzọ

Enwebeghị ọmụmụ iji mụọ nsonaazụ nke nkwadebe Krestor ® n'ikike ịnya ụgbọ na iji usoro. Agbanyeghị, dabere na Njirimara ọgwụ, Krestor ® ekwesịghị inwe ụdị mmetụta ahụ. Ekwesịrị ịkpachara anya mgbe ị na-anya ụgbọ ala ma ọ bụ na-arụ ọrụ metụtara ịba ụba nke nlebara anya na mmeghachi omume psychomotor (ujo nwere ike ime n'oge usoro ọgwụgwọ).

N'ihi oke cholesterol, dọkịta m depụtara Krestor na mbụ 5

N'ihi oke cholesterol, dọkịta m nyere iwu ka Krestor na mbụ 5 mg, wee mụbaa ọgwụ ahụ ruo 10 mg. Ihe ngosi a ka mma. N'ime afọ 3, ule ọrụ imeju oge niile gosiri na ihe niile dị n'usoro. Mgbe ahụ ọnọdụ ọjọọ bilitere, nke ahụ ọkụ, ọnya mgbu, isi ọwụwa, mmamịrị gbara ọchịchịrị, nsogbu ihi ụra, belatara agụụ. Dọkịta zipụrụ maka nyocha zuru oke - nyocha ọbara, ụzarị ọkụ, ultrasounds na mkpokọta tomography. Ọ bịara doo anya na ihe na-akpata ya esighị na mmiri nkịtị ma ọ bụ flu. Achọpụtara nsogbu na imeju. Akwụsịrị m ị Cụ Crestor ozugbo.

Obe ewedatala cholesterol m na triglycerides. Ma achọpụtara m na mmụba

Obe ewedatala cholesterol m na triglycerides. Ma achọpụtara m na-abawanye ibu, ike ọgwụgwụ, mbelata ume. Enwere mgbu mgbu, mgbu n'aka, mgbu na agba. Dọkịta ahụ mere nyocha ma chọpụta ihe kpatara ọrịa ndị a. Akwụsịrị m ịrestụ Krestor, n'ime izu 2 ruo atọ kwa, ịdị m mma na ahụike laghachiri na nkịtị. Abịara m rie azụ̀ m, wee malite moreaa ntị na nri. Enwere m olile anya na ị gaghị alaghachi azụ were were ihe.

Anọwo m ọgwụ Krestor 10 mg kemgbe ihe karịrị afọ 10. Ọ rụrụ ọrụ dị mma,

Anọwo m ọgwụ Krestor 10 mg kemgbe ihe karịrị afọ 10. Ọ rụrụ ọrụ dị mma, belata cholesterol m na nkịtị. Ma, ruo ọtụtụ afọ, enwere m mgbu mgbu, ndị dọkịta enweghịkwa ike ịkọwa ya. N'ụzọ ụfọdụ, enyi nke akụkọ ahụ na ihe mgbu nke nkwonkwo m nwere ike ịbụ nsonaazụ nke ihe Krestor. Iji lelee echiche ya, m kwụsịrị ị drinkingụ ọgwụ. N'ezie, ọ bụ mgbe ọnwa ole na ole ka nkwonkwo ahụ kwụsịrị. Yabụ ugbu a, anabataghị m Krestor ọzọ.

A na m a 2.5ụ 2.5 mg nke Crestor kwa ụbọchị (nke a bụ ọkara mbadamba 5 mg). Ọ gbadara n'ezie

A na m a 2.5ụ 2.5 mg nke Crestor kwa ụbọchị (nke a bụ ọkara mbadamba 5 mg). Nke a belatara cholesterol m nke ukwuu site na 248 ruo 193. Ọ bụghị ihe ịtụnanya, mana ezigbo ọgwụ zuru oke. Amalitere m ị drinkingụ mmanya 10 kwa ụbọchị, mana enwere ọnya afọ na ịdị elu nke enzymes imeju.Dọkịta gwara m ka m nwalee ihe oyiyi ndị ọzọ, mana ha niile nwere otu mmetụta. Ya mere, anyị belatara ọgwụ nke Crestor ruo mgbe nsonaazụ ya kwụsịrị. Ọ na-arụ ọrụ zuru oke ma enweghị mmetụta dị egwu ọ bụla na-ahụ.

Na mgbakwunye na ịbụ onye na-arịa ọrịa shuga, ana m enwekwa cholesterol dị ukwuu (nke a chọpụtara na-achọpụta)

Na mgbakwunye na ịbụ onye na-arịa ọrịa shuga, enwerekwa m cholesterol dị elu (nke a chọpụtara afọ 12 gara aga). Anọ m erighị nri na-ezighi ezi, anaghịkwa eri àkwá na anụ. Ma, cholesterol m di elu. Achọghị m ịnara statins ọ bụla, n'ihi na enwere m nsogbu site na ihe ọkụ ọkụ na-enweghị atụ mgbe m na-ewere onye na-ekwu okwu. Mana n’oge ọkọchị gara aga, ndị na-egosi ihe jọrọ njọ nke na Krestor .ụrụ mmanya. Agbanyeghị, amalitere m na 5 mg ọtụtụ ugboro n'izu. Ugbu a, ọnwa asatọ ka nke ahụ gasịrị, kọlestrọl m dị ọcha dịkwa ka ihe niile ndị ọzọ na-egosi na-adị. My endocrinologist nwere obi ụtọ ma kwuo na ọ nweghị ihe kpatara ịbawanye ọgwụ ahụ gaa na 10 mg. N’ezie, mgbe ụfọdụ enwere m ihe mgbu na nkwonkwo aka na nkwonkwo aka na nkwonkwo ụkwụ, mana nke a bụ nke a pụrụ ịnagide.

Ngwakọta na ụdị ntọhapụ

Ihe na-arụ ọrụ nke Krestor bụ rosuvastatin. Ihe mejupụtara ọgwụ ahụ nwekwara ihe ndị ọzọ na-enyere aka: lactose, cellulose, magnesium stearate, calcium phosphate, na ndị ọzọ. Crestor dị n'ụdị nke mbadamba pink, ọdịdị gbara agba maka ebumnuche ọnụ. Dabere na akwụkwọ ntuziaka radar, uzommeputa Latin dị ka nke a: Rp.: Rosuvastatini 0.01 D.t.d.N.10 na tab.obd. S. 1.

Ọgwụ dị n'ọtụtụ usoro onunu ogwu:

Crestor 5 mg
Crestor 10 mg
Crestor 20 mg
Crestor 40 mg.

Dabere na usoro onunu ogwu, enwere ihe osise n’elu otu akụkụ nke mbadamba. Dịka ọmụmaatụ, na usoro onyunyo nke 10 mg, ọ na-ekwu "ZD4522 10" na ya. A na-etinye mbadamba na mbadamba ihe dị ka iberibe 7. N'ime otu kaadiboodu enwere ike blister 1, 4, 14.

Ọtụtụ mgbe, a na-azụta ọgwụ nke 10 mg - mbadamba 98, ya bụ, enwere blisters 14 na ngwugwu ahụ. N'iburu n'uche na edepụtara statins maka iji ogologo oge, ọtụtụ na-achọpụta na ọ bara uru ịzụta nnukwu nchịkọta otu mgbe.

Ciplekpụrụ nke ịrụ ọrụ

Obe bu ihe eji ewusi mmiri ike, ya bu, ikwusi ume. Ebumnuche ya na ebido n’ịbelata ọnụọgụ nke lipoproteins nke ogo dị iche iche n’ahụ. Imechi imeju - aru nke mere maka cholesterol, rosuvastatin, ihe eji arụ ọrụ nke ọgwụ ahụ, nwere ihe mgbochi na mmepụta nke ọtụtụ enzymes.

Ma, cholesterol na-abanye n'ọbara abụghị naanị imeju na-emepụta. Akụkụ nke ihe a na-abanye ahụ ahụ nri, ọkachasị abụba, nri ratụ ratụ. Ihe nke ọgwụ ahụ na-enyere aka sachapụ arịa ọbara nke obere lipoproteins dị ala nke ebukalarị. A na-akpọ ọnọdụ a mmalite nke atherosclerosis.

Ọ bụrụ na atherosclerosis amalitelarị ịmalite, akwara ọbara na akwara na-emetụta nkwonkwo cholesterol ma ọ bụ ite, Krestor nwere mmetụta bara uru na ha. Ọ na-abanye n’ime arịa, na-asachapụ ha nkwakọba akụ. N'ihi nke a, lumen n'ime arịa na akwara akwara na-abawanye, obara ọbara na mpaghara ndị emetụtara ya na-akawanye mma.

Otu n'ime nsogbu nke atherosclerotic plaques bụ thrombosis, nke na-eyi mbibi arịa ma ọ bụ akwara akwara. Statins na-egbochi nke a site na ịbawanye nkọwapụta nke ha site na ibelata ogo nke paịlị.

Krestor bụ nke ọgbọ nke anọ, a na-ahụta otu a kachasị arụ ọrụ. Na agbanyeghi eziokwu na nkwadebe ya na-enyere aka belata cholesterol nke “jọrọ njọ” n'ọbara, ha na-amụba arụpụta “nke ọma”. Cholesterol dị mma "bụ ihe dị mkpa maka ịrụ ọrụ nke ọtụtụ akụkụ ahụ dị n'ime, ịmịpụta homonụ, ike nke mkpụrụ ndụ na usoro ndị ọzọ.

Ntụziaka maka ojiji

Ntuziaka maka iji ọgwụ ahụ dị na ngwugwu ọ bụla, ọ dị mkpa ka ndị ọrịa mara onwe ha tupu ha ejiri ọgwụ. Ejiri usoro onunu ogwu na usoro nhazi ka dibịa na-esonye niile n’otu n’otu. Na-abụkarị oge a na-akwụghị ụgwọ, isi ihe bụ ị toụ ọgwụ kwa ụbọchị n'otu oge.

Dabere na ọtụtụ ndị ọkachamara, oge mgbede bụ ihe kachasị adaba maka ịnwe statins, ebe ọ bụ na ka ọ na-erule njedebe nke ụbọchị, ọnụ ọgụgụ kọlestrọl dị n'ọbara karịrị nke ụtụtụ.

Ezubere ngwaahịa a maka nchịkwa ọnụ, were ntakịrị mmiri washedacha. Kwesighi ịta ata. Tupu ị chọpụta usoro onunu ogwu a, a na-enye onye ọrịa ọgwụ nyocha ọfụma iji chọpụta ọnọdụ arịa, ọnụọgụ ọbara, yana akụkụ nke akwara obi.

Ọtụtụ mgbe usoro ọgwụgwọ mbụ bụ 10 mg. Otu ọnwa mgbe ịmalite ọgwụgwọ, onye ọrịa ahụ ga-enyocha nyocha ọbara, ma ọ bụrụ na ọgwụ ahụ dị irè, ọ nweghị mmetụta ọ bụla, enwere ike ịba ụba usoro ọgwụ ahụ ruo 20-40 mg kwa ụbọchị. Mgbe ahụ, n'oge usoro ọgwụgwọ niile, ọ dị mkpa iji nyocha oge niile iji nyochaa nsonaazụ ahụ ma dozie usoro ịha.

Ọ bụrụ na enyere ọgwụ ọgwụ maka mgbochi ọrịa nke akwara ọbara, usoro izizi na-abụkarị 5 mg. Ka oge na-aga, dị ka dọkịta na-eleta kwuru, enwere ike ịba ụba.

Elezie, etinyere statins maka ndụ, ọ bụrụ na ọ baghị, mgbe ahụ ka oge ha ga - ewe ihe dị ka ọnwa 3-4. Gaghị akwụsị ị takingụ ọgwụ n’oge na-adịghị anya, dibịa nọ na-ahụ maka na-edepụta atụmatụ nke a ga-ebelata usoro ị ga -eme kwa ụbọchị, naanị mgbe ahụ ka enwere ike ịkwụsị.

Ihe ngbanwe

Ọgwụ ọ bụla dị na statin otu nwere ọtụtụ contraindications maka iji ya, ebe ọ bụ na ha na-ahụta ike. Enweghị ike iji obe mee ihe maka ihe ngosi ndị a:

afọ ruo afọ 18
ịtụrụ ime na inye ụmụ ara,
nnweghi anabataghị rosuvastatin ma ọ bụ akụrụngwa ọ bụla ọzọ esonye mejupụtara,
ọrịa imeju na-adịghị ala ala n'oge iwe,
myopathy.

Maka ndị ọrịa nọ n'ihe ize ndụ nke ịmalite ọrịa myopathy, a na-egbochi ọgwụ ọgwụ nke 40 mg kwa ụbọchị. Ọtụtụ mgbe, etinyere ha Crestor 20 mg ma ọ bụ 10 mg mbụ.

Na ọgwụ ọjọọ eme ihe na contraindicated na ndị ọrịa na-a excessiveụ oké mmanya. Ebe ọ bụ na ebumnuche nke ihe oyiyi dị iche iche bụ maka imeju, ọ bụrụ na ọ nwere nsị nke ihe ọholicụ ,ụ na-egbu egbu, ọ gaghị egbochi nrụgide dị otú ahụ. Ọ bụrụ na onye ọrịa na-arịa ị alcoụbiga mmanya ókè akwụsị ị drinkingụ mmanya, na -aga usoro ọgwụgwọ na mgbake, enwere ike ịkọwa ọgwụgwọ, mana ọ ga-amalite site na obere usoro.

Nsonaazụ

N'etiti ndị ọrịa na-ewere Krestor, mmetụta ndị na-adịkarị na ndị na-agbasoghị ndụmọdụ dọkịta, na-agafe oke ọgwụ ma ọ bụ na-eleghara iwu nke contraindications. Ihe nwere ike ịmetụta ya gụnyere:

ọrịa dyspeptik, afọ na-egbu mgbu,
isi ọwụwa, nkụda mmụọ,
nhazi
akpụkpọ anụ ahụ, itching,
myalgia
asthenia
anya puff.

Kedu ihe ka mma Krestor ma ọ bụ Rosuvastatin

Nkezi ego rosuvastatin 20 mg 28 PC. bụ ihe dịka 550 rubles, ebe ọnụahịa Crestor fọrọ obere ka ọ bụrụ ugboro isii karịa. Maka nke a, ọtụtụ ndị ọrịa na-ahọrọ ịhọrọ nhọrọ dị ọnụ ala. Kedu ihe dị iche n'etiti ọgwụ ike, belụsọ maka ụdị ọdịiche ahụ na ọnụahịa?

Krestor bụ nke akụkụ nke ọgbọ nke anọ gara aga, nke a bụkwa uru bụ isi nke ọgwụ ahụ. Ọ bụ ụzọ dị mma, nke dị nchebe. Dabere na ọtụtụ ndị dọkịta, ọ bụrụ na ịmalite ịmalite statins, ma ị ga-eme ya ogologo oge, ikekwe maka ndụ, mgbe ahụ nke a kwesịrị ịbụ ezigbo mma nke mbụ. Ọ bụ ọgwụ a bụ Krestor.

Abamuru nke Crestor, nke, n'adịghị ka ụdị mkpụrụ ndụ ihe nketa ya na ihe nnọchi anya egosipụtara na gọọmentị, gụnyere: