Mbadamba 30 nke Glyclazide 30 mg: ntuziaka maka ojiji

Ọrịa hypoglycemic, nke bụ usoro nke usoro oyuche sulfonylurea II. Na-akwalite mmepụta nke insulin site na mkpụrụ ndụ-and-ma weghachi profaịlụ nke ahụ. Theakingụ ọgwụ ahụ na -ebelata oge site na oge iri nri ruo na mmalite insulin insulin, ebe ọ na-eweghachi usoro mbu (nke mbụ) ma buliekwa agba nke abụọ. Na -ebelata agbam ume kachasị elu mgbe ị risịrị nri. Ọ na - eme ka anụ ahụ mara insulin.
Na mgbakwunye, ọ na-ebelata ihe egwu. thrombosissite na-ebelata mkpọchi na nrapado ọgụgụ plateletna - eweghachi ọrịa anụ ahụ parietal fibrinolysisna - eme ka microcirculation dịkwuo mma. Mmetụta a dị mkpa n'ihi na ọ na-ebelata ohere ịkpa oke nsogbu - retinopathies na microangiopathies. Site na nephropathy mamịrị, enwere ịbelata proteinuria megide ndabere nke ọgwụgwọ a ọgwụ. Ọ na - egbochi mmepe nke atherosclerosis, ebe ọ nwere ihe anti-atherogenic.

Njirimara nke usoro onunu ogwu Gliclazide MV nye ịta ahụ ọgwụgwọ na njikwa ọkwa glucose dị mma n'ime awa iri abụọ na anọ.

Mlọ ọgwụ

N’itinye ngwa ngwa n’ime ogwara nri, ogo nke nnabata dị elu. A na-ekpebi itinye uche kachasị (mgbe ewere 80 mg) mgbe awa 4. A na-ekwurita mkparịta ụka na protein na ihe dịka 97%. A na-enweta ntinye uche ịlele mgbe nchịkwa gachara ụbọchị abụọ. Metabolized n'ime imeju na-metabolites 8. Ihe ruru 70% bụ akụrụ, akwara - 12%. Mwepu ọkara ndụ nke gliclazide nkịtị bụ awa 8, agbatịwo ruo awa 20.

Ihe ngbanwe

• shuga na-arịa insulin na-arịa ọrịa shuga mellitus,
• ketoacidosis,
• ọrịa mamịrị,
• oke akụrụ gbasara akụrụ / imeju,
• na-arịa ọrịa lactose innerance, ọrịa malabsorption,
• n’otu oge nnabata Danazol ma obu Phenylbutazone,
• afọ ruo afọ 18
• hypersensitivity
• ime, lactation.

Eji nlezianya debe ya na agadi, ya na nri adighi adighi nma. hypothyroidism, hypopituitarismsiri ike Ọrịa ọrịa obi Ischemicwee kpọọ atherosclerosis, adrenal ezughi okeogologo oge ọgwụgwọ glucocorticosteroids.

Nsonaazụ

• ọgbụgbọ, vomiting, afọ mgbu,
• thrombocytopenia, erythropenia, agranulocytosis, hemolytic anaemia,
• nfụkasị vasculitis,
• ọnya ọnyá, itching,
• imeju imeju,
• mmebi anya
• hypoglycemia(bụrụ na ị doụbiga ya ókè).

Glyclazide, ntuziaka maka ojiji (Usoro na usoro onunu ogwu)

Mbadamba nke Glyclazide N'usoro ọgwụ mbido 80 kwa ụbọchị, ugboro 2 n’ụbọchị 30 nkeji tupu nri. N’ọdị n’ihu, a na-agbazi ọgwụ a na-agbaso, kwa ụbọchị ị na-eri kwa ụbọchị bụ 160 mg, ma kacha bụ 320 mg. Mbadamba ụrọ Glyclazide MB nwere ike ịhụ mbadamba mbugharị oge niile. Ọ bụ dọkịta ga-ekpebi ihe ga-ekwe omume ma dochie ya na ọgwụ a.

Glyclazide MB 30 mg iri oge 1 n’oge nri ụtụtụ. A na-amalite ịgbanwe ọgwụ mgbe izu 2 gachara. Ọ nwere ike ịbụ 90 -120 mg.

Ọ bụrụ na ọgwụ gị riri gị ọgwụ, ị gaghị anara ya okpukpu abụọ. Mgbe ị ga-eji nke a dochie ọgwụ belata shuga ọzọ, oge mgbanwe agaghị achọ ya - ha ga - ebido were ya echi. Ikekwe ngwakọta na biguanides, insulinalfa glucosidase inhibitors. Maka nwayọọ gbasara akwara họpụtara n'otu usoro onunu ogwu. N'ime ndị ọrịa nwere ọrịa hypoglycemia, a na-eji ntakịrị ọgwụ.

Dodoụbiga ya ókè

A na - egosipụta njupụta mgbanwe site na mgbaàmà hypoglycemia: isi ọwụwa, ike ọgwụgwụ, adịghị ike siri ike, ịsụgharị, palpitations, ọbara mgbali elu, arrhythmiairo ụra mkpasu iweiwe, oke iwe, mmeghachi omume na-egbu oge, ọhụụ na-enweghị isi na okwu, ịma jijijianya ntughari ogwe, bradycardiaọnwụ nke mmụọ.

Na agafeghị oke hypoglycemiana-enweghị mmụọ ịta ahụhụ, belata dose nke ọgwụ ma ọ bụ nwekwuo ego nke carbohydrates na-enye nri.

Na ọnọdụ hypoglycemic siri ike, ịga ụlọ ọgwụ ozugbo na enyemaka dị mkpa: iv 50 ml nke 20 gụrụ 20-30% gluuze, mgbe ahụ, 10% dextrose ma ọ bụ gluuze mmiri na-atasị. N'ime ụbọchị abụọ, a na-enyocha ọkwa glucose. Dialysis adighi ike.

Mmekorita

Jiri ya mee ihe Cimetidinenke na-abawanye ịta ahụhụ gliclazidenke ahụ nwere ike ibute nnukwu hypoglycemia.

Mgbe etinyere ya na Verapamil ịkwesịrị ijikwa ọkwa nke glucose.

A na - eme ka hypoglycemic mmetụta mgbe ejiri ya salicylatesusoro Pyrazolone, sulfonamides, kafiin, Phenylbutazone, Theophylline.

Ojiji nke ndị na - egbochi beta na - ahọrọ ihe a na - ebute nsogbu ahụ hypoglycemia.

Mgbe itinye akwụkwọ Acarboseakara mmado hypoglycemic akara.

Mgbe ị na-eji GCS (gụnyere ụdị ngwa ọzọ). mgbochi ego, diuretics, estrogenna progestins, Diphenin, Rifampicin mmetụta belata shuga nke ọgwụ a.

Nyocha banyere Gliclazide

Ka ọ dị ugbu a, usoro eji eme ihe n'ọtụtụ ebe.ọgbọ nke abụọ sulfonylureas, nke Gliclazide bụ, n'ihi na ha dị elu karịa ọgwụ ọjọọ nke ọgbọ gara aga na ịdị ike nke mmetụta hypoglycemic, ebe ọ bụ na njikọta nke ndị nabatara β-cell dị ugboro 2-5 karịa, nke na-enye ohere iji nweta nsonaazụ mgbe ị na-edepụta obere usoro. Ọgbọ a ọgwụ adịghị yikarị ịkpata nsonaazụ.

Otu akụkụ nke ọgwụ ahụ bụ na etolite ọtụtụ metabolites n'oge mgbanwe metabolic, na otu n'ime ha nwere mmetụta dị ukwuu na microcirculation. Ọtụtụ ọmụmụ egosila na enwere ihe ọghọm nke nsogbu microvascular (retinopathyna nephropathy) na ọgwụgwọ gliclazide. Ogo-ebelata angiopathy, oriri na-edozi ahụ na-adịwanye mma, na-apụ n'anya vaskụla stasis. Ọ bụ ya mere e ji nye ya ọgwụ maka nsogbu ọrịa shuga mellitus (angiopathy, nephropathyna mbu nwa akuko okpu, retinopathies) a na-akọkwara nke a site n'aka ndị ọrịa bufere nke a, zigara ya ị takingụ ọgwụ a.

Ọtụtụ na-ekwusi ike na a ga-ewere mbadamba mgbe nri ụtụtụ gasịrị, nke nwere carbohydrates zuru oke, agụụ maka ụbọchị adịghị anabata. Ma ọ bụghị ya, megide nri dị kalori dị ala na mgbe ọ gbasasịrị nnukwu ahụ ike, enwere ike mmepe hypoglycemia. Site na nrụgide anụ ahụ, ọ dị mkpa ịgbanwe dose nke ọgwụ. Mgbe ha drinkingụsịrị mmanya, ụfọdụ ụfọdụ nwekwara ọnọdụ nke ịba ụba.

Ndị okenye na-elebara ọgwụ hypoglycemic anya karịsịa, ebe ọ bụ na ihe egwu ha nwere ịba ụba hypoglycemia mụbara. Na njikọ a, ọ kaara ha mma iji ọgwụ adịghị eme ihe (ọ dị mma gliclazide).
Ndị ọrịa na-achọpụta na nyocha ha banyere ịdị mma nke iji mbadamba ihe eji emegharị emezi: ha na-eme nwayọ na nha, yabụ a na-eji ya otu ugboro n'ụbọchị. Na mgbakwunye, ogo ya dị irè ji okpukpu abụọ dị ala karịa ihe ị na-eme gliclazide.

Enwere akụkọ na mgbe ọtụtụ afọ (site na 3 ruo 5 site na mmalite nke oriri), nguzobe malitere - mbelata ma ọ bụ enweghị ọrụ nke ọgwụ ahụ. N'ọnọdụ ndị dị otú ahụ, dọkịta ahụ họọrọ njikọ nke ndị ọzọ hypoglycemic na-elekọta mmadụ.

Usoro onunu ogwu na nhazi

Ọ na-atụ aro ilo mbadamba mbubreyo n'oge nri ụtụtụ ọ bụla na-adịghị ata ata ma ọ bụ nhichapịa. A ga-ahọrọ ọ̀gù n'okwu nke ọ bụla, dabere n'ọkwa glucose dị n'ọbara yana glycosylated haemoglobin.

Ọkwa mbụ akwadoro maka ndị okenye (gụnyere maka ndị agadi years 65 afọ) bụ mg mg 30 / ụbọchị. N'ọnọdụ nchịkwa zuru oke, enwere ike iji ọgwụ a na dose a maka ọgwụgwọ mmezi. Site na nchịkwa nchịkwa na-ezughị ezu, enwere ike ịba ụba kwa ụbọchị ruo 60 mg, 90 mg ma ọ bụ 120 mg. Mmụba ọ̀nwe ga-ekwe omume ọ bụghị tupu mgbe ọnwa 1 gachara ọrịa ọgwụ ae nyere gị na mbụ. Thebọchị kwa ụbọchị bụ 30-120 mg na 1 dose. Oke kachasị atụ aro kwa ụbọchị bụ 120 mg. Ọ bụrụ na ị youụ otu ọgwụ ma ọ bụ karịa, ịgaghị a aụ ọgwụ dị elu na nke na-esote ya, o kwesịrị iwere dose ahụ Agbaghara n’echi ya.

Na-agbanwe site na ị takingụ gliclazide ahaziri ahazi gliclazide 30 mg nke mbadamba emegharị-1 mg. Enwere ike dochie grumlazide 80 mg na mbụ nwere ike iji 1 tab. 30 mg gbanwetụrụ glyclatone. Mgbe ị na-ebufe ndị ọrịa site na ọgwụ gliclazide 80 mg na gliclazide MV 30 mg, a na-atụ aro iji nlezianya nyochaa ọkwa nke glucose ọbara.

Ejikọtara ya na ọgwụ hypoglycemic ọzọ: Glyclazide-Borimed MV 30 mg nwere ike ijikọ ya na biguanidines, alpha-glucosidase inhibitors ma ọ bụ insulin.

Site na nchịkwa nchịkwa zuru oke, a na-eji ọgwụ nlezianya ede ọgwụ insulin ọgwụ.

Ọ dịghị mkpa mmezi nke ọgwụ ọgwụ ọjọọ maka ndị gbara afọ 65, yana ndị ọrịa nwere ajọ akwara dị obere ruo na-agafeghị oke.

Mmetụta akụkụ

Site na nri diges: dyspepsia (ọgbụgbọ, vomiting, afọ ọsịsa, mgbu nke afọ, afọ ntachi) - ogo na-ebelata nri, adịkarịghị - ọnya imeju (ịba ọcha n'anya, cholestatic jaundice - chọrọ ịkwụsị ọgwụ, ịba ụba ọrụ nke transminases “imeju”, alkaline phosphatase).

Site na akụkụ ahụ dị na hemopoietic: mgbochi nke ụmị ọbara ọbara (anaemia, thrombocytopenia, leukopenia, granulocytopenia).

Mmeghachi omume nfụkasị ahụ: akpụkpọ itching, urticaria, ọnya anụ ahụ gụnyere maculopapular na bullov), erythema, vasculitis nfụkasị.

Ngosipụta nke hypoglycemia: dizzness, ike ọgwụgwụ, ụra, isi ọwụwa na ọsụsọ, adịghị ike, ụjọ, ịma jijiji, paresthesia. Ihe mgbaàmà ndi ozo nke hypoglycemia: agụụ, nsogbu ihi ụra, obi mgbawa, oke iwe, ịda ogbenye, ịbelata mmeghachi omume, obi erughị ala, ọgba aghara, ahụrụ anya na nsogbu okwu, aphasia, paresis, ọgba aghara mmetụta, mmetụta nke enweghị ike, enweghị njide onwe onye, ​​iche echiche, nchekasị, ụkwara ume ọkụ, iku ume ugboro ugboro, bradycardia, ihi ura, na mfu nke uche, nke puru ibido coma na onwu.

Na mgbakwunye, akara nke njikwa nchịkwa adrenergic nwere ike ịmalite, dị ka ọsụsọ, akpụkpọ clammy, nchegbu, tachycardia, ọbara mgbali elu, obi palpitations, angina pectoris na obi arrhythmia. N’ezie, ngosipụta ndị a na-adabakarị na-apụ n’anya mgbe ha nwesịrị carbohydrates (sugar). Ndị na-atọgbọ ụtọ anụahụ enweghị mmetụta ọ bụla na ịkwụsị hypoglycemia. Ahụmahụ nke iji nkwadebe ndị ọzọ na-egosi na ọ nwere ike ịlaghachi azụ nke hypoglycemia ọbụlagodi n'ọnọdụ ndị ahụ mgbe usoro nke eburu iji kpochapụ ya yiri ka ọ dị mma. N'ime mwakpo dị egwu hypoglycemia, ọ bụrụgodị na enwere ike iwepụ ya nwa oge site na ị sugarụ shuga, nlekọta ahụike ngwa ngwa ma ọ bụ ụlọ ọgwụ dị mkpa.

Ahụhụ anya: Ọhụhụ anya na - adị n’iru ga - ekwe omume, ọkachasị na mbido ọgwụgwọ, n’ihi mgbanwe nke ọkwa glucose ọbara.

Si na akuko obi: akwara arteritis, obi ọgụ, infarction myocardial, ọrịa ụbụrụ, imi ụbụrụ, akwara akwara bụ ọrịa akwara, hypotension, edema, palpitations, tachycardia, thrombophlebitis.

Njirimara ngwa

Enwere ike ịnye ya naanị ndị ọrịa ahụ nri nri ha bụ oge niile ma nwee nri ụtụtụ. Ọ dị ezigbo mkpa iji nwee nri zuru oke nke nri carbohydrates ihe egwu nke ịbawanye hypoglycemia na-abawanye site na enweghị nri ma ọ bụ erighị ihe na-edozi ahụ, yana oriri nke nri na-adịghị mma na carbohydrate. Hypoglycemia na-etolitekarị obere nri kalori, mgbe ọ gbasịrị ogologo ma ọ bụ mgbatị ahụ siri ike, mgbe ị drinkingụ mmanya na-egbu egbu, ma ọ bụ mgbe ị na-ewere ọtụtụ ọgwụ hypoglycemic n'otu oge. A, mgbaàmà hypoglycemia na-apụ n'anya mgbe ị risịrị nri nwere carbohydrates (dịka shuga). Okwesiri iburu n’uche na iwere ihe uto n’enweghi aka iwepu ihe mgbaàmà hypoglycemic. Hypoglycemia nwere ike ịmaliteghachi n'agbanyeghị ngbanwe mbụ dị irè nke ọnọdụ a. Ọ bụrụ na ọrịa hypoglycemic nwere agwa akpọ ma ọ bụ na-adịte aka, ọbụlagodi n'ihe banyere nkwụghachi nwa oge mgbe iri nri zuru oke na carbohydrates, nlekọta ahụike mberede dị mkpa, ruo ụlọ ọgwụ.

Mgbe ị na-a theụ ọgwụ ahụ, mkpebi siri ike nke ibu ọnụ glucose ọbara ọbara na Hbly glycosylated Hb dị mkpa.

Ọrịa na-efe efe na-arịa ọrịa febrile nwere ike ịchọ nkwụsị nke ọgwụ hypoglycemic nke nwoke na nchịkwa nke insulin.

E kwesiri ịdọ ndị ọrịa aka na ntị gbasara ịba ụba nke hypoglycemia n'ihe banyere ị etụ ọgwụ ethanol na ọgwụ ethanol nwere (gụnyere mmepe nke disulfiram-like mmeghachi omume: mgbu afọ, ọgbụgbọ, vomiting, isi ọwụwa), NSAIDs, na agụụ.

Imeghari otu ọ̀ dị mkpa maka ịghara oke nri anụ ahụ na nke mmetụta uche, mgbanwe nri.

A na-ahụta ihe egwu dị elu nke ịbawanye hypoglycemia n'ọnọdụ ndị a: ọjụjụ onye ọrịa ma ọ bụ enweghị ike (karịchaa ndị agadi) ịgbaso ọgwụ ndị dọkịta ma chịkwaa ọnọdụ ya, nri ezughị ezu na oge ezighi ezi, nri iri nri, ibu ọnụ na ịgbanwe nri, enweghị nhịahụ dị n'etiti arụ ọrụ anụ ahụ na ọnụọgụ sọlfọ were, renal ezughi oke ma ọ bụ oke imeju dara, ịdoụfe ọgwụ MV gliclazide, ụfọdụ ọrịa endocrine (ọrịa thyroid, pituitary na ezughi oke adrenal).

N'ime ndị ọrịa nwere nnukwu ịba ọcha n'anya na / ma ọ bụ ọdịda akụrụngwa, mgbanwe mgbanwe ọgwụ na / ma ọ bụ ọgwụ ọgwụ nke gliclazide ga-ekwe omume. Ọrịa hypoglycemia nke na-etolite na ndị ọrịa a nwere ike ịdị ogologo oge, n'ọnọdụ ndị dị otú a, ọgwụgwọ kwesịrị ekwesị ozugbo dị mkpa.

Ọ dị mkpa ịgwa onye ọrịa ahụ na ndị ezinụlọ ya banyere ihe ize ndụ nke ịmalite ọrịa hypoglycemia, ihe mgbaàmà ya na ọnọdụ ndị metụtara mmepe ya. A ga-agwa onye ọrịa banyere ihe ọghọm na uru ọgwụgwọ ọgwụgwọ chọrọ. Ọrịa ahụ kwesịrị ịkọwa mkpa iri nri, mkpa maka mmega ahụ oge niile na ilele ọkwa glucose ọbara.

N'oge usoro ọgwụgwọ, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike ịdị ize ndụ chọrọ mgbanye uche na ọsọ nke mmeghachi omume psychomotor.

Nchedo nchekwa

Okenye, enweghi usoro na / ma obu ihe oriri na-edozi ahụ, ọrịa siri ike nke akwara obi (gụnyere ọrịa obi na akwara, atherosclerosis), hypothyroidism, adrenal or pituitary insufficiency, hypopituitarism, renal na / ma ọ bụ imeju, ogologo glucocorticosteroid therapy, mmanya , ụkọ glucose-6-phosphate dehydrogenase, ọgwụgwọ concomitant na phenylbutazone na danazole.

Hypoglycemia. Enwere ike inye ọgwụgwọ Gliclazide naanị ndị ọrịa nwere ike inye ha nri oge niile (gụnyere nri ụtụtụ).Ihe ize ndụ nke hypoglycemia na-abawanye site na nri nwere kalori, mgbe ọ gbasịrị ogologo oge ma ọ bụ mgbatị anụ ahụ, ị ​​drinkingụ mmanya na-egbu egbu, ma ọ bụ n'ihe metụtara ojiji nke ọtụtụ ọgwụ hypoglycemic sitere na otu sulfonylurea.

Enweghị umeji ma ọ bụ ọrụ akụrụ. N'ime ndị ọrịa dị otú ahụ, ọrịa nke hypoglycemia nwere ike ịdị ogologo, nke chọrọ itinye usoro zuru oke.

Ofdị irè nke ọgwụ hypoglycemic ọgwụ ọ bụla, gụnyere gliclazide, n'ọtụtụ ndị ọrịa na-ebelata ka oge na-aga: nke a nwere ike ịbụ n'ihi mmụba nke ọrịa shuga ma ọ bụ mmeghachi omume na-adịghị ike maka ọgwụ ahụ.

Mwepụta wepụtara ya na ihe mejupụtara

Sdị usoro onunu ogwu - mbadamba-eji aka ya wepụta: ihe fọrọ nke nta ka ọ bụrụ ọcha ma ọ bụ na-acha ọcha, biconvex, 30 mg na 60 mg oval, 90 mg Capsule-qaab, G90 na-ese n’otu akụkụ (30 mg: 10 PC.) , na kaadiboodu nke 3, 6 ma ọ bụ 9 blisters, 15 pcs ọ bụla na ọnya, na kaadiboodu nke 2, 4 ma ọ bụ 6 blisters, 60 mg nke ọ bụla: 15 PC na blister, na kaadiboodu ukwuu nke 2, 4, 6 ma ọ bụ 8 blisters , 90 mg: pc 10. Na ọnya, na ngwungwu kaadiboodu nke 3, 6 ma ọ bụ 9 blisters).

Otu mbadamba 1 nwere:

• ihe na-arụ ọrụ: gliclazide - 30 mg, 60 mg ma ọ bụ 90 mg,
• ndị na - ahụ maka ọgwụ: hypromellose (100 mPas - viscosity nominal maka ihe ngwọta 2% nke mmiri), lactose monohydrate, colloidal silicon dioxide, magnesium stearate.

Tụkwasị na nke a, na mbadamba 30 mg - hypromellose (4000 mPas), carbonate carbon.

Ihe ngosi maka ojiji

Ekwadoro iji Glyclades maka ọgwụgwọ nke ndị ọrịa okenye nwere ụdị ọrịa shuga 2 nke ọrịa na-adịghị mma na usoro ọgwụgwọ nri, mmega ahụ na oke ibu.

Na mgbakwunye, a na-enye ọgwụ ahụ maka mgbochi nke nsogbu na ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa: belata ihe ize ndụ nke microvascular (retinopathy, nephropathy) na macrovascular (infarction myocardial infarction, stroke).

Usoro onunu ogwu na nhazi

Ana eburu mbadamba nkume ndị a n'oge nri ụtụtụ, otu oge kwa ụbọchị.

A na-atụle usoro nke Glyclades n'otu n'otu dabere na ọkwa nke gemocosylated haemoglobin (HbAlc) na ileba anya ịbanye n'ọbara glucose oge niile.

Sing na-atụ aro ka a na-a dailyụ kwa ụbọchị: ọgwụ mbụ bụ 30 mg, ma ọ bụrụ na ọgwụ a na-enye gị ohere iji nweta nsonaazụ kacha mma nke ụlọ ọgwụ, a na-ewere ya dịka mmezi. Na enweghị nchịkwa glycemic chọrọ, ekwesịrị ịbawanye dose ahụ (na-eburu n'uche nchịkọta nke glucose na ọbara) gaa 60 mg, 90 mg ma ọ bụ 120 mg kwa ụbọchị. Ọ bụrụ na mbelata n'ọbara glucose n'ọbara izu abụọ nke ọgwụgwọ, enwere ike ịbawanye ọnụọgụ ahụ na nkeji nke izu anọ ma ọ bụ karịa. Ọ bụrụ na mgbe izu abụọ nke iji ọgwụ ahụ, ịta nke glucose n'ọbara anaghị ebelata, a ga-abawanye dose ahụ na njedebe nke izu nke abụọ nke ọgwụgwọ.

Ogo kachasị nke ụbọchị bụ 120 mg.

Mgbe ị na-agbanwe na iwere mbadamba ihe ọpụrụiche ozugbo nwere 80 mg nke glyclazide, ekwesịrị iburu n'uche na mmetụta nke otu mbadamba ihe dị ka otu 30 mg nke mbadamba Gliclada. Inggbanwe ọgwụ a ga-esoro jiri nlezianya nyochaa oke nke glucose na ọbara.

Uzo mbu nke ogwu a mgbe ị na - agbanwe site na uzo obula (obuna kachasi) nke aga

Ndị na-enye mmadụ ọgwụ hypoglycemic kwesịrị ịbụ 30 mg. N'okwu a, ọ dị mkpa iburu n'uche usoro, ụzọ dị irè na oge ọrụ nke onye nnọchite gara aga.

Ọ bụrụ na onye nnọchi anya hypoglycemic dị na mbụ nwere T_1/2iji gbochie mmụba mmụba na mmepe nke hypoglycemia, ịkwụsị nwa oge (ọtụtụ ụbọchị) ịkwụsị ọgwụgwọ. Mgbe ịmaliteghachi ọgwụgwọ, ọ dị mkpa ijikọ 1-2 izu iji nlezianya nyochaa ọnọdụ onye ọrịa.

Enwere ike iji ọgwụ a jikọta ya na ngwakọta biguanides, thiazolidinedione, alfa-glucosidase inhibitors ma ọ bụ insulin.

Ibido usoro ọgwụgwọ yana insulin dị mkpa na nlekọta nlekọta ahụike.

Site na ịdị nwayọ nwayọ na nha nrụpụta akwara, idozi creatinine (CC) nke 15-80 ml / min, ọgwụgwọ ndị ọrịa karịrị afọ 65 adịghị mkpa idozi dose.

Iji mezuo ọkwa ebumnuche nke HbAlc, na mgbakwunye na mmụba nwayọọ nwayọọ na ị ofụ ọgwụ ahụ, ọ dị mkpa iji nlezianya soro usoro nri pụrụ iche ma mee mmega ahụ.

Ntụziaka pụrụ iche

N'oge ntinye nke Glyclades, onye ọrịa kwesịrị ịgbaso nri mgbe niile, jide n'aka na ị ga-etinye nri ụtụtụ, ebe ọ bụ na ị irụbiga carbohydrate n'oge nri, nri abalị ma ọ bụ na-ezughị ezu na-abawanye ihe ize ndụ nke hypoglycemia. Ihe mgbaàmà hypoglycemia: agụụ na-egbu, isi ọwụwa, ọgbụgbọ, ọgbụgbọ, ike ọgwụgwụ, mgbakasị ahụ, mgbakasị ahụ, ike ọgwụgwụ, nsogbu ụra, nrụrụaka, enweghị ike itinye uche n'ihe, ọgbụgba, mmeghachi omume oge, nkụda mmụọ, ịma jijiji, aphasia, paresis , nsogbu uche, ọnwụ nke njide onwe onye, ​​nkwarụ, delirium, bradycardia, iku ume, enweghị mmụọ nke mmụọ. Na mgbakwunye, onye ọrịa ahụ nwere ike ịnwe ọsụsọ dị ukwuu, nchekasị, ọbara mgbali elu, tachycardia, palpitations, angina pectoris, cardiac arrhythmias, clammy and skin skin.

Iji kwụsị mmeghachi nke hypoglycemic, ọ dị mkpa iji carbohydrates (shuga), n'ọnọdụ ndị siri ike, achọrọ nlekọta ahụike mberede (glucose intravenous).

Ojiji nke nyocha onwe ya nke ọkwa glucose na plasma ọbara na-enye gị ohere idekọ mgbanwe n'oge ọnọdụ onye ọrịa.

Rictrapagidesi ike na usoro dosing - ị theụ ọgwụ n'oge nri ụtụtụ - na-ebelata ohere nke ịmalite inwe mmetụta achọghị n'ụdị dyspepsia.

Mgbe akara nke cholestatic jaundice pụtara, ekwesịrị ịhapụ mbadamba nkume.

Nnabata na nri kalori, ogologo oge ma ọ bụ nnukwu ahụ ike, n'otu oge ahụ iji ndị ọzọ hypoglycemic, ị alcoholụ mmanya ma ọ bụ ịdoụ ọgwụ oke na-abawanye ohere nke hypoglycemia.

Ihe ndị na-eme ka ịbawanye ụba nke hypoglycemia gụnyere ọrịa ndị metụtara ya: ọdịda akụrụ, ọdịda akwara siri ike, ọrịa thyroid, ụkọ pituitary-adrenal, hypopituitarism. Gbanwe Njirimara nke gliclazide na hepatic ma ọ bụ ọdịda akụrụ oke nwere ike ime ka onye ọrịa nwee ogologo oge nke hypoglycemia.

Gaghị akpatula nguzozi n'etiti oke carbohydrates riri, mmega ahụ na nrụgide obi.

Iji ọgwụ ndị ọzọ eme ihe na-enweghị nkwekọrịta na dọkịta.

Mbelata na nsonaazụ hypoglycemic ọgwụ nwere ike ibute ọrịa febrile, trauma, ọrịa na-efe efe, oke ọkụ, yana ọrụ ịwa ahụ. Ọnọdụ ndị a nwere ike ibute mkpa ịnyefe onye ọrịa na ọgwụgwọ insulin.

Okwesiri iburu n’uche na n’otu oge eji beta-igbochi, reserpine, clonidine, guanethidine nwere ike kpuchie ngosiputa nke akwara hypoglycemia.

Ọ bụrụ na ọgwụgwọ ọgwụgwọ nke ọgwụ ahụ belatara mgbe ọgwụgwọ ogologo oge gasịrị, dọkịta ahụ kwesịrị ijide n'aka na onye ọrịa ahụ na-agbaso ndụmọdụ nke usoro dosing, nri, na mmega ahụ. Ọ bụrụ na onye ọrịa ahụ ejiri nlezianya na-agbaso ha, mgbe ahụ, mbelata njikwa glycemic bụ n'ihi ọganihu nke ọrịa ahụ.

Ojiji nke glycases n'ihe banyere ụkọ glucose-6-phosphate dehydrogenase nwere ike ime ka mmepe nke anaemia hemolytic.

N'oge a na-eji ọgwụ ahụ eme ihe, a na-atụ aro ka ndị ọrịa nwere ọrịa mellitus kpachara anya mgbe ha na-anya ụgbọala na usoro.

Mkparịta ụka ọgwụ ọjọọ

Site n'otu oge eji Glyclades:

• miconazole, phenylbutazone, danazole, ethanol na-ebute mmụba dị ukwuu na mmetụta hypoglycemic nke ọgwụ, na-abawanye ihe ize ndụ nke hypoglycemia, coma,
• insulin, biguanides, acarbose, beta-blockers, sulfonamides, angiotensin na-agbanwe enzyme inhibitors (enalapril, captopril), fluconazole, cimetidine, monoamine oxidase inhibitors, ọgwụ mgbochi mgbochi steroidal, ọgwụ mgbochi clarithromycin
• chlorpromazine dị elu (ihe karịrị 100 mg kwa ụbọchị) doses na-eme ka ọkwa glucose dị n'ọbara, belata insulin,
• tetracosactide, GCS maka sistemu, intraarticular, mpụga na nke akụkụ anọ na-ebulite ihe ize ndụ nke ịmalite ketoacidosis,
• salbutamol, ritodrin, terbutaline na-abawanye glucose ọbara,
• warfarin na anticoagulants ndị ọzọ na-akwalite mmetụta ọgwụgwọ ha.

Ihe atụ nke Gliklad bụ: mbadamba - Diabeton MV, Gliclazide MV, Diabefarm MV, Glidiab.

Mpempe usoro onunu ogwu

30 mg na 60 mg mbadamba mbugharị ndenye

Otu mbadamba ihe nwere:

ike ihe - gliclazide 30.0 mg ma ọ bụ 60.0 mg,

ndị na-ebu ụzọ: silikon dioxide anhydrous colloidal, hydroxypropyl methylcellulose, sodium stearyl fumarate, talc, lactose monohydrate.

Mbadamba ụcha dị ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ na-acha ọcha na agba, na-enwe ọdịdị cylindrical na bevel (maka usoro nke 30 mg).

Mbadamba dị ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ na-acha ọcha na agba, na-enwe ọdịdị cylindrical, facet na notch (maka usoro 60 mg).

Ngwongwo ogwu

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, a na-etinye gliclazide kpamkpam site na eriri afọ. Iri nri anaghị emetụta ogo nke mmịpụta. Nnukwu gliclazide na plasma na-abawanye nwayọ n'oge awa isii mbụ mgbe ọ jesịrị nchịkwa wee rute ala dị larịị nke dị site na 6 ruo awa nke iri na abụọ. Ọdịiche nke abụọ na-adị obere. Mmekọrịta dị n'etiti dose ruo 120 mg na plasma concentration curve of the ọgwụ bụ ịdabere na oge ahịrị. Ihe dị ka 95% nke ọgwụ ahụ na-egbochi protein ndị dị na plasma.

Gliclazide bụ metabolized n'ime akụrụ ma na-abụkarị ya na mmamịrị. A na - emegharị anụ ahụ ọkachasị site na akụrụ n'ụdị metabolites, ihe na-erughị 1% dịpụrụ adịpụ na mmamịrị ya. Ọ dịghị metabolites nọ n'ọrụ na plasma.

Ọkara ndụ (T1 / 2) nke gliclazide a awa 16 (awa 12 ruo 20).

N'ime ndị agadi, enweghị mgbanwe dị ukwuu na pọọmọnokinetic ọgwụ.

Otu ọgwụ kwa ụbọchị nke 60 mg na-enye nsonaazụ dị mma nke gliclazide na plasma maka ihe karịrị awa 24.

Mlọ ọgwụ

Gliclazide MV bụ ọgwụ nke hypoglycemic nke sitere na otu nke usoro II nke usoro sulfonylurea, nke dị iche na ọgwụ ndị yiri ya site na ọnụnọ nke heterocyclic nke N-nwere nwere njikọ njikọ endocyclic.

Gliclazide MB na -ebelata ọkwa nke glucose n'ọbara, na-akpali nzuzo nke insulin site na mkpụrụ ndụ nke agwaetiti nke Langerhans. Mgbe afọ 2 gasịrị ọgwụgwọ, ọtụtụ ndị ọrịa ka nwere mmụba na ọkwa insprandial insulin na zoro ezo nke C-peptides.

Na ụdị ọrịa mellitus nke 2, ọgwụ a na-eweghachi mmalite nke insulin na-emeghachi omume na nzaghachi glucose ma na-eme ka akụkụ nke abụọ nke insulin ahụ dịkwuo elu. A na-ahụta mmụba dị ukwuu na mmiri insulin na nzaghachi mkpali n'ihi nri nri na nchịkwa glucose.

Gliclazide MV nwere mmetụta na microcirculation. Ọ na - ebelata ihe ọghọm nke thrombosis nke obere ọbara, na - emetụta usoro abụọ nwere ike itinye aka na mmepe nke nsogbu na ọrịa shuga mellitus: ịhapụ akụkụ nke platelet na nrapado na mbelata ihe ndị na - eme ka platelet (beta-thromboglobulin, thromboxane B2), yana mweghachi nke ọrụ fibrinolytic vaskụla endothelium na ụba ọrụ nke plasminogen anụ ahụ na-eme ihe.

Mkparịta ụka ọgwụ ọjọọ

Ọgwụ na-eme ka mmetụta nke Gliclazide MV dịkwuo (ohere dị elu nke hypoglycemia)

Miconazole (mgbe ejiri ya rụọ ọrụ ma ọ bụ tinye ya na mucosa ọnụ n'ụdị gel): na-eme ka mmetụta hypoglycemic nke MV Gliclazide (hypoglycemia nwere ike tolite ruo hypoglycemic coma).

Akwadoro maka iji:

Phenylbutazone na - akwalite mmetụta hypoglycemic nke ihe njikọ sulfonylurea (na - ewepụ ha na nkwukọrịta na protein plasma na / ma ọ bụ na - eme ka mkpochapu ahụ ghara ịdị).

Ọ ka mma ka ị useụ ọgwụ mgbochi mbu ọzọ.

Mmanya na-eme ka hypoglycemia kwusi, na-egbochi mmeghachi omume na-akwụghachi ụgwọ, nwere ike itinye aka na mmepe nke hypoglycemic coma.

Ọ dị mkpa ịhapụ ị ofụ mmanya na ị medicationsụ ọgwụ, nke gụnyere mmanya na-egbu egbu.

Njikọ ndị chọrọ ịkpachara anya:

Ojiji nke otu ọgwụ ndị a n’otu oge nwere ike ịka njọ hypoglycemic mmetụta nke ọgwụ Gliclazide MV ma n’ọnọdụ ụfọdụ iduga mmalite nke hypoglycemia:

ndị ọzọ antidiabetic (insulins, acarbose, biguanides), beta-blockers, fluconazole, angiotensin-na-agbanwe enzyme inhibitors (captopril, enalapril), antagonists H2 na-anabata ihe, ndị na-egbochi ọgwụ mgbochi monoamine oxidase (MAO I), sulfonamides na ọgwụ mgbochi mbufụt Steroid.

Ọgwụ ndị na-akụda ike Glyclazide MV

Akwadoro maka iji:

A naghị atụ aro iji ihe oriri ike na danazol n'ihi ihe dị ka mmụba nke glucose ọbara. Ọ bụrụ na ọ gaghị ekwe omume ịjụ ojiji nke danazol, kọwaara onye ọrịa ahụ mkpa ọ dị ịchịkwa mkpokọta glucose na ọbara na mmamịrị. Mgbe ufodu, achoro imeghari onodu nke Gliclazide MV n'oge ọgwụgwọ na mgbe danazol.

Njikọ ndị chọrọ ịkpachara anya:

Chlorpromazine na ọnụọgụ dị elu (karịa 100 mg kwa ụbọchị) na-eme ka glucose dị n'ọbara, na -ebelata ihe nzuzo nke insulin.

Glucocorticosteroids (usoro na ngwa mpaghara: intraarticular, anụ ahụ na njikwa azụ) na tetracosactrin na-abawanye glucose ọbara na mmepe nke ketoacidosis nwere ike, n'ihi mbelata nke nnabata nke carbohydrate site na glucocorticosteroids.

β2-adrenostimulants - ritodrin, salbutamol, terbutaline (ojiji usoro) na-ebute mmụba nke ọkwa glucose.

Lezienụ anya na mkpa ọ dị ịchekwa glucose ọbara. Ọ bụrụ na ọ dị mkpa, nyefee onye ọrịa ahụ ọgwụ insulin.

Ọ bụrụ n’ịchọrọ iji nchịkọta ndị dị n’elu, ịkwesịrị ịkwụ ụgwọ nlebara anya pụrụ iche n'ịchịkwa ọkwa glucose ọbara. Ọ nwere ike ịdị mkpa ịmegharị ọnụọgụ nke MV Glyclazide ma n'oge ọgwụgwọ njikọta na mgbe ịkwụsị ọgwụ ọzọ.

Nchịkọta aka nke Gliclazide MV nwere ọgwụ anticoagulant (warfarin, wdg) nwere ike ibute mmụba na ọgwụ anticoagulant nke ọgwụ ndị dị otú ahụ. Enwere ike ịchọ ndozi ọgwụ Anticoagulant.

Ozi izugbe

Akwụkwọ ikike ndebanye aha maka Gliclazide MV bụ nke ụlọ ọrụ Russia Atoll LLC nyere. Ọgwụ dị n'okpuru nkwekọrịta ahụ bụ ndị ụlọ ọrụ Samara Ozara na-emepụta Ozone. Ọ na-emepụta ma na-etinye mbadamba, ma na-ejikwa njikwa ha. Enweghị ike ịkpọ Gliclazide MV kpamkpam ọgwụ ụlọ, ebe ọ bụ na azụrụ ọgwụ maka ya (otu glyclazide) na China. N’agbanyeghi nke a, enweghi ihe ọjọọ nwere ike ikwu maka ịdị mma nke ọgwụ. Dabere na ndị na-arịa ọrịa shuga, ọ dịghị njọ karịa French Diabeton nwere otu ihe mejupụtara.

Nkpirisi MV nke aha ogwu a gosiputara na ihe ahu no n’ime ya ka eweputara ya, ma obu ogologo oge. Glyclazide na-ahapụ mbadamba mbido ahụ n'oge kwesịrị ekwesị na ebe kwesịrị ekwesị, nke na-ahụ na ọ banyeghị n'ọbara ozugbo, mana na obere akụkụ. N'ihi nke a, a na-ebelata ihe ize ndụ nke mmetụta ndị na-adịghị mma, enwere ike ị drugụ ọgwụ ahụ obere oge.Ọ bụrụ na emebi iwu nke mbadamba ihe, ogologo ọrụ ya ga-efu, yabụ, ntuziaka maka ojiji adịghị atụ aro ka ibepu ya.

A gụnyere Glyclazide na listi ọgwụ ndị dị mkpa, yabụ endocrinologists nwere ohere iji nye ya ndị ọrịa shuga n'efu. Ọtụtụ mgbe, dị ka ọgwụ siri kwuo, ọ bụ MV Gliclazide ụlọ bụ analog nke Diabeton mbụ.

Kedu ka ọgwụ si arụ ọrụ?

All gliclazide tọrọ atọ na ntupo na-abanye n'ime ọbara ma kegide ya na protein ya. Nọmalị, glucose na-abanye n’ime mkpụrụ ndụ beta ma na-akpali ndị na-anabata ndị pụrụ iche nke na-akpali ntọhapụ nke insulin. Glyclazide na-arụ ọrụ site n'otu ụkpụrụ ahụ, na-akpalite njikọta nke homonụ.

Ọ bụghị nanị mmetụta MV Glyclazide na-arụpụta na-emepụta insulin. Ọgwụ nwere ike:

1. Belata insulin iguzogide. A na-ahụ nsonaazụ kachasị mma (ịmụba insulin na-abawanye site na 35%) na anụ ahụ.
2. Belata mkpụkọ glucose site na umeji, si otu a na-ahụ ọ̀ha oke ibu ọnụ ya.
3. Na-egbochi egbochi mkpụkọ ọbara.
4. Na-akpali njikọ nke nitric oxide, nke a na-etinye aka na ịchịkwa nrụgide, belata mbufụt, ma melite inye anụ ahụ n’akụkụ anụ ahụ.
5. Na-arụ ọrụ dịka antioxidant.

Mwepụta ewepụtara na usoro onunu ogwu

Na mbadamba, Gliclazide MV bụ 30 ma ọ bụ 60 mg nke ihe arụ ọrụ. Ihe inyeaka bu: cellulose, nke eji dika bulking, silica na magnesium stearate dika emulsifiers. Mbadamba ụcha ọcha ma ọ bụ ude, edobere na blisters nke 10-30 iberibe. Na ngwugwu nke 2-3 blisters (30 ma ọ bụ mbadamba 60) na ntuziaka. Enwere ike kee Glyclazide MV 60 mg na ọkara, maka nke a enwere nsogbu na mbadamba ihe.

Ọgwụ kwesịrị ị drunkụ mmanya n’oge nri ụtụtụ. Gliclazide na-arụ ọrụ n'agbanyeghị agbanyeghị shuga dị n'ọbara. Yabụ na hypoglycemia apụtaghị, o nweghị nri a ga-egwupụ, onye ọ bụla n’ime ha kwesịrị inwe ihe dị ka carbohydrates n’otu. Ọ bụ ihe amamihe dị na ya iri ugboro isii n'ụbọchị.

Usoro usoro ịhọrọ usoro onunu ogwu:

Ntụziaka zuru ezu maka ojiji

Dika ntuziaka ulo ogwu nke Health nke Russia Federation siri kwuo, ekwesiri inye gliclazide iji mee ka insulin na-enyocha ya. N'ụzọ ezi uche dị na ya, a ga-enyocha enweghị mmezu nke onwe ya site na nyocha nke onye ọrịa. Dabere na nyocha, nke a anaghị eme mgbe niile. Ndị na-agwọ ọrịa na endocrinologists depụtara ọgwụ "site na anya". N’ihi ya, ihe karịrị insulin chọrọ ya bụ nke zoro ezo, onye ọrịa ahụ na-achọ iri nri mgbe niile, ibu ya na-eji nwayọọ nwayọọ na-abawanye, ụgwọ maka ọrịa shuga adịghịkwa ezu. Na mgbakwunye, mkpụrụ ndụ beta nke nwere ụdị ọrụ a na-ebibi ngwa ngwa, nke pụtara na ọrịa ahụ na-aga ọkwa nke ọzọ.

Esi zere ụdị nsonazụ ndị a:

1. Bido nrube isi na nri ndi oria mamiri (table nke 9.)
2. Cemalite mmeghari nke nọ n'ọrụ kwa ụbọchị.
3. Na-atụkwa ibu dị ka o kwesịrị. Abụba gabigara ókè na-elu ọrịa shuga.
4. Na-a gluụ glucophage ma ọ bụ analogues ya. Ogo kachasị mma bụ 2000 mg.

Ma naanị ma ọ bụrụ na usoro ndị a ezughi maka shuga nkịtị, ị nwere ike iche maka gliclazide. Tupu ịmalite ọgwụgwọ, ọ bara uru ịme nyocha maka C-peptide ma ọ bụ insulin iji jide n'aka na njikọta homonụ ahụ nwere nsogbu.

Mgbe glycated haemoglobin dị elu karịa 8.5%, enwere ike inye MV Gliclazide tinyere nri na metformin nwa oge, ruo mgbe a ga-akwụghachi ọrịa shuga ume. Mgbe nke ahụ gasịrị, a na-ekpebi okwu banyere ịhapụ ọgwụ iji n'otu n'otu.

Mpempe akwụkwọ Mpempe akwụkwọ

JLLC “Lekpharm”, Republic of Belarus, 223141, Logoysk, ul. Minskaya, 2a, tel / faksị: +375 1774 53 801, e-mail: [email protected]

Adresị nke nzukọ a na-anabata nnabata n'aka ndị na-azụ ahịa maka otu ngwaahịa dị na mpaghara nke Republic of Kazakhstan

Onye nnọchi anya ụlọ ọrụ nke Lekpharm COOO na Republic of Kazakhstan,

050065, Republic nke Kazakhstan, Almaty, district Alm, ul. Kazybek bi, 68/70, akuku nke st. Nauryzbay batyr, tel. 8 (727) -2676670, faksị 8 (727) -2721178

Aha, adres na kọntaktị nkọwa (ekwentị, faksị, e-mail) nke nzukọ a na mpaghara Republic of Kazakhstan na-ahụ maka ịdebanye aha ndebanye nke nchekwa ọgwụ.

Onye nnọchi anya ụlọ ọrụ nke Lekpharm COOO na Republic of Kazakhstan,

050065, Republic nke Kazakhstan, Almaty, district Alm, ul. Kazybek bi, 68/70, akuku nke st. Nauryzbay batyr, tel. 8 (727) -2676670, faksị 8 (727) -2721178,

Omume ọgwụ

Mgbu na nkesa

Mgbe ị takingụsịrị ọgwụ ahụ n'ime, gliclazide na-abanye kpamkpam na eriri afọ. Nnukwu gliclazide na plasma na-abawanye nwayọ n'oge awa isii mbụ mgbe ọ jesịrị nchịkwa wee rute ala dị larịị nke dị site na 6 ruo awa nke iri na abụọ. Onweghi ike n’otu n’otu di ala. Iri nri anaghị emetụta ogo nke mmịpụta. Olu nkesa kesara odi lita 30. Njikọ protein protein Plasma bụ ihe dịka 95%. Otu ọgwụ kwa ụbọchị nke ọgwụ Gliclada® na-eme ka e nwee ike na - agbakọ uru glyclazide na plasma ọbara ruo ihe karịrị awa 24.

Gliclazide bụ metabolized nke ukwu na imeju. Metabolites ndị a rụpụtara anaghị arụ ọrụ ọgwụ. Mmekọrịta dị n'etiti ọgwụ a were rue 120 mg na ịta ọgwụ na plasma bụ ntinye kwụụrụ n'oge.

Ndụ ndụ ọkara (T1 / 2) nke gliclazide bụ awa 12-20. Ọ na - abụkarị site akụrụ n'ụdị metabolites, ihe na-erughị 1% dị na mmamịrị agbanweghi.

Pharmacokinetics n'ihe gbasara ọrịa

N'ime ndị agadi, enweghị mgbanwe mgbanwe dị egwu a na-achọpụta na ọgwụ ọgwụ.

Gliclada® bụ ọgwụ ọgwụ hypoglycemic nke sitere na usoro nke usoro II nke usoro sulfonylurea dị iche, nke dị iche na ọgwụ ndị yiri ya site na ọnụnọ nke heterocyclic nke N-nwere nwere njikọ nke endocyclic.

Glyclada® na-ebelata glucose ọbara site na-akpali insulin na mmiri site n'agwaetiti Langerhans nwere mkpụrụ ndụ R. Mgbe afọ abụọ nke ọgwụgwọ gasịrị, mmụba nke ọkwa insprandial insulin na nzuzo nke C-peptides na-adịgide. Na ụdị ọrịa mellitus nke 2, ọgwụ a na-eweghachi mmalite nke insulin na-emeghachi omume na nzaghachi glucose ma na-eme ka akụkụ nke abụọ nke insulin ahụ dịkwuo elu. A na-ahụta mmụba dị ukwuu na mmiri insulin na nzaghachi mkpali n'ihi nri nri na nchịkwa glucose.

Na mgbakwunye na emetụta metabolism metabolism, Glyclada® nwere mmetụta na microcirculation. Ọgwụ ahụ na-ebelata ihe ize ndụ nke thrombosis nke obere arịa, na-emetụta usoro abụọ nwere ike itinye aka na mmepe nke nsogbu na ọrịa shuga mellitus: ịhapụ akụkụ nke platelet na nrapado na mbelata ihe ndị na-eme ka platelet rụọ ọrụ (beta-thromboglobulin, thromboxane B2), yana mweghachi nke fibrinolytic vaskụla endothelial ọrụ na ụba ọrụ nke plasminogen anụ ahụ.

Etu ị ga-esi mee n’oge afọ ime

Ntụziaka maka iji gbochie ọgwụgwọ na Gliclazide n'oge ime na lact. Dabere na nhazi FDA, ọgwụ a bụ nke klas C. Nke a pụtara na ọ nwere ike imetụta mmepe nke nwa ebu n’afọ, mana anaghị akpata ọgbụgba. Gliclazide dị mma iji dochie ọgwụ insulin tupu ime ime, n'ọnọdụ ndị dị oke njọ - na mmalite.

Anwalebeghị ohere ị ofụ nwa nwere gliclazide. Enwere ihe akaebe na nhazi sulfonylurea nwere ike ịbanye na mmiri ara ehi ma kpatara hypoglycemia n'ime ụmụ aka, yabụ machibidoro ojiji ha n'ime oge a.

Dọkịta nke Sciences Medical, Isi nke Institute of Diabetology - Tatyana Yakovleva

Agụọla m ọrịa shuga kemgbe ọtụtụ afọ. Ọ na-atụ ụjọ mgbe ọtụtụ mmadụ nwụrụ, nweekwa nkwarụ karịa n'ihi ọrịa shuga.

Emere m ngwa ngwa izisa ozi ọma - Endocrinological Research Center nke Russian Academy of Medical Sciences jikwaa aka ịmalite ọgwụ na-agwọ ọrịa shuga mellitus kpamkpam. N'oge a, ịdị irè nke ọgwụ a na-eru nso 98%.

Ozi ọma ọzọ: Ministri Ahụike echekwaala maka mmemme pụrụ iche nke na-akwụ ụgwọ ọgwụ dị elu. Na Russia, ndị ọrịa mamịrị ruo Mee Mee 18 (isonye) nwere ike inweta ya - Naanị 147 rubles!

Mmetụta akụkụ na ị andụbiga mmanya ókè

Mmetụta kachasị njọ nke MV Glyclazide bụ hypoglycemia. Ọ na - apụta mgbe mmepụta insulin karịrị ihe achọrọ maka ya. Ihe kpatara ya nwere ike bụrụ ịdoụ ọgwụ gabigara ókè, ịalụ mmiri, ma ọ bụ enweghị carbohydrates dị na ya, yana oke mmega ahụ. Ọzọkwa, ịdalata shuga nwere ike ime ka mkpokọta gliclazide n'ọbara n'ihi akụrụ na akụrụ nke imeju, mmụba nke ọrụ insulin na ụfọdụ ọrịa endocrine. Dika nyocha, na ọgwụgwọ nke sulfonylureas na hypoglycemia, ihe fọrọ nke nta ka ọ bụrụ ndị ọrịa mamịrị na-eche ihu. Enwere ike iwepụ ọtụtụ shuga na oge dị mfe.

Dịka iwu, hypoglycemia jikọtara ya na akara akara: oke agụụ, oke nke oke, nsogbu, adịghị ike. Patientsfọdụ ndị ọrịa jiri nwayọ kwụsị inwe mmetụta ndị a, afọ shuga ha na-etinye ndụ n'ihe egwu. Ọ dị ha mkpa ịchịkwa glucose ugboro ugboro, gụnyere n'abalị, ma ọ bụ bufee ya ná mbadamba shuga ndị ọzọ na-enweghị mmetụta dị otú ahụ.

A na-enyocha ihe ize ndụ nke omume ndị ọzọ na-achọghị na Gliclazide dị ka ọ na-adịghị ahụkebe. Omume:

• nsogbu digestive n'ụdị ọgbụgbọ, mmegharị afọ, ma ọ bụ afọ ọsịsa. Nwere ike ibelata ha site na ị Gụ Glyclazide n'oge nri kachasị ọkụ,
• akpụkpọ ahụ, ọ na-adịkarị n'ụdị ihe ọkụ ọkụ na-eso ya na itching,
• mbelata platelet, sel ọbara ọbara, sel ọbara. Ihe mejupụtara ọbara ahụ ga-alaghachi na nke ya mgbe ekpochapụrụ Gliclazide,
• mmụba nwa oge na ọrụ nke enzymes imeju.

Onye glyclazide MV na-contraindicated

Kedu ihe aga-edochi ya

Russian gliclazide bụ ọgwụ dị ọnụ ala, kama nke ahụ, ọ nwere ọgwụ dị elu, ọnụahịa maka ịkwakọ nke Gliclazide MV (30 mg, 60 iberibe) ruru 150 rubles. Dochie ya na analogues bụ naanị ma ọ bụrụ na ereghị mbadamba ndị mbụ.

Originalụ ọgwụ mbụ bụ Diabeton MV, ọgwụ niile ọzọ nwere otu ihe mejupụtara, gụnyere Gliclazide MV bụ mkpụrụ ndụ ihe nketa, ma ọ bụ mbipụta. Ọnụ ego Diabeton ji ihe dị ka okpukpu abụọ dị elu karịa ụdị mkpụrụ ndụ ihe nketa ya.

Glyclazide MV analogues na ndị nọchiri aha Rọshịa (a na-egosi nkwadebe ntọhapụ gbanwetụrụ).

• Glyclazide-SZ nke Severnaya Zvezda CJSC mepụtara.
• Golda MV, Pharmasintez-Tyumen,
• Gliclazide Canon sitere na Mmepụta Canonpharm,
• Glyclazide MV Pharmstandard, Pharmstandard-Tomskkhimfarm,
• Diabetalong, onye na-emepụta MS-Vita,
• Gliklada, Krka,
• Glidiab MV nke Akrikhin,
• Diabefarm MV Pharmacor Production.

Ọnụahịa nke analogues bụ 120-150 rubles kwa ngwugwu. Gliklada mere na Slovenia bụ ọgwụ kachasị ọnụ site na listi a, mkpọ nwere ego ruru 250 rubles.

Nyocha banyere ọrịa mamịrị

Agụrụ m na Galvus na-enye otu mmetụta ahụ, mana dịkwa nchebe karịa na shuga dị ala. Aga m arịọ dọkịta ka ọ jiri Gliclazide dochie ha.

Jikere muta! You chere na nchịkwa ọgwụ ogologo oge na ọgwụ bụ naanị ụzọ eji egbochi shuga? Ọ bụghị eziokwu! Nwere ike ịchọpụta nke a n'onwe gị site na ịmalite iji ya. gụkwuo >>