Lisinopril Teva: ntuziaka maka ojiji, analogues, emeputa, nyocha

- ọbara mgbali elu (na monotherapy ma ọ bụ yana ọgwụ ndị ọzọ na - egbochi mmiri),

- nkụda obi na-adịghị ala ala (dịka akụkụ nke ọgwụgwọ njikọta),

- ọgwụgwọ mbụ nke ọrịa myocardial infarction (na awa iri abụọ na anọ mbụ jiri ụdị ọrịa ọ na - eme ka ọ dịgide na - egbochi ọsịsọ na nkụchi obi).

- nepatropathy na-arịa ọrịa mamịrị (na-agbadata albuminuria na ndị ọrịa nwere ụdị ọrịa shuga 1 nke nwere ọbara mgbali nkịtị, yana ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa obi mgbali elu).

Ihe ngbanwe

- Hypersensitivity na lisinopril, ihe ndị ọzọ nke ọgwụ ma ọ bụ ndị ọzọ na-egbochi ACE,

- akụkọ ihe mere eme nke anakpaedeede (gụnyere ojiji nke ihe ndị ọzọ ACE inhibitors),

- amụba amụba na Quincke edema na / ma ọ bụ idiopathic angioedema,

- gbara afọ 18 (agbadobeghị ịdị irè na nchekwa),

- Ime ime na oge inye nwa ara.

Ihe akpachara anya: akwara ọnya akwara ma ọ bụ stenosis nke otu akụrụ akwara na-enwe ọganihu azotemia, ọnọdụ mgbe akụrụ, akụrụ, akwara na-eji ọnya ọgbụgba dị elu (AN69R), azotemia, hyperkalemia, stenosis nke aortic orifice, hyperomolosse cardifatipe hypotension, ọrịa ụbụrụ (gụnyere ọrịa ụbụrụ), akwara obi, ọrịa obi, ọrịa obi na-efe efe. anụ ahụ na - ejikọ ọnụ (gụnyere scleroderma, system lupus erythematosus), mgbochi nke ụmị ọkpụkpụ, ọnọdụ na-agbadata na mbelata ọbara (BCC) (gụnyere n'ihi afọ ọsịsa, ọgbụgbọ), na-eji ndị ọrịa nri nri amachibidoro. nnu tebụl, n’ebe ndị ọrịa agadi nọ, iji ọgwụ ndị a na-eme n’otu oge eme ihe n’otu, ihe ndị na-eme ka a na-eme ya, ọgwụ ndị ọzọ, antihypertensive ọgwụ, NSAIDs, lithium, antacids, colestyramine, ethanol, insulin, nkwadebe hypoglycemic ndị ọzọ. Tami, allopurinol, procainamide, gold preparations, antipsychotics, tricyclic antidepressants, barbiturates, beta-blockers, calcium ọwa blockers ngwa ngwa.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

A na-ewere ọgwụ Lisinopril-Teva n'ọnụ ọnụ 1 / ụbọchị, n'agbanyeghị oge nri, ọkacha mma n'otu oge ahụ. A na-ahọrọ dose ahụ n’otu n’otu. Site na ọbara mgbali elu, ndị ọrịa anaghị anata ọgwụ mgbochi ọgwụ ndị ọzọ na - eji ọgwụ mgwu mmiri 5 mg / ụbọchị. Na enweghị ọgwụgwọ ọgwụgwọ, a na-amụba dose ahụ kwa ụbọchị 2-3 site na 5 mg na dose nke 20-40 mg / ụbọchị (ịba ụba dose ahụ karịa 40 mg / ụbọchị anaghị ebute mgbadawanye n'ọbara.)

Onu ogugu mmezi nke ubochi niile bu 20 mg. Oke kachasị kwa ụbọchị bụ 40 mg. Mmetụta ọgwụgwọ na-etolite mgbe izu 2-4 gachara site na mbido ọgwụgwọ, nke ekwesịrị ịtụle mgbe ị na-abawanye dose ahụ. Site na mmetụta na-ezughị ezu, iji otu oge eji ọgwụ ahụ na ọgwụ ndị ọzọ na-egbochi mkpịsị ugodi.

Ọ bụrụ na onye ọrịa ahụ natara ọgwụgwọ mbido site na diuretics, mgbe ahụ, a ga-akwụsị ị theụ ọgwụ ndị a ụbọchị 2-3 tupu mmalite nke iji ọgwụ ahụ Lisinopril-Teva. Ọ bụrụ na nke a agaghị ekwe omume, mgbe ahụ ọgwụ mbụ nke Lisinopril-Teva ekwesịghị gafere 5 mg / ụbọchị. N'okwu a, mgbe ị takingụsịrị ọgwụ nke mbụ, a na-atụ aro ịlele ahụike maka ọtụtụ awa (a na-enweta nsonaazụ kachasị mgbe ihe dị ka awa 6), ebe ọ bụ na mbelata ọbara mgbali elu nwere ike ime.

Omume ọgwụ

ACE inhibitor, na-ebelata nguzobe nke angiotensin II site na angiotensin I. Mbelata nke ọdịnaya nke angiotensin II na-eduga na mbelata nke mbuputara nke aldosterone. Na-ebelata mmebi nke bradykinin ma mee ka njikọ nke prostaglandins dịkwuo elu. Na -eme ka ngụkọta akwara vaskụla mkpokọta (OPSS), ọbara mgbali elu, bute nrụgide, na -eme ka mkpụrụ ndụ mwepụta na -ewepụta mmụba nkeji oge ma nwekwuo ndidi mmega ahụ dị n'ime ndị ọrịa nwere nkụchi obi. Ọ na-eme ka akwara akwara dị elu karịa akwara. Ejiri mmetụta ụfọdụ na ikpughe na sistemụ renin-angiotensin-aldosterone (RAAS). Site n'iji ogologo oge, hypertrophy nke myocardium na mgbidi nke akwara ndị dị n'ụdị resistive na-ebelata. Ọ na - eme ka ọkpụkpụ ọbara na ischemic myocardium dị mma.

Lisinopril na-ebelata albuminuria. Ọ naghị emetụta ịta glucose ọbara na ndị ọrịa nwere ọrịa mellitus ma ọ dịghị ebute mmụba na ikpe nke hypoglycemia.

Nsonaazụ

Site na sisitemu obi: oge ​​- mbelata akara ọbara mgbali, orthostatic hypotension, infrection - acre myocardial infarction, tachycardia, palpitations, Raynaud's syndrome, adịkarịghị - bradycardia, tachycardia, ihe nrịba ama nke mgbaàmà obi dara ada, ụbụrụ na - enweghị isi, obi mgbu.

Site na akwara dị n’etiti: oge ​​ụfọdụ - akpịrị ọgbụgba, isi ọwụwa, ugboro ugboro - ike mmụọ, paresthesia, nsogbu ịrahụ ụra, ọnya afọ, adịkarịghị - ọgba aghara, ọrịa asthenic, na - agbatị akwara nke aka na egbugbere ọnụ ya, ihi ụra.

Na akụkụ nke sisitemu hematopoietic na lymphatic sistemu: adịkarịghị - mbelata hemoglobin, hematocrit, ọ dịkarịghị - leukopenia, neutropenia, agranulocytosis, thrombocytenia, eosinophilia, erythropenia, hemolytic anaemia, lymphadenopathy, ọrịa na-arịa ọria.

Ntụziaka pụrụ iche

Ọtụtụ mgbe, mbelata ọbara mgbali elu na-apụta na mbelata na BCC kpatara ọgwụgwọ ọrịa, mbelata ọdịnaya nke sodium chloride na nri, usoro ọgwụgwọ, afọ ọsịsa ma ọ bụ vomiting. N'okpuru nlekọta nke dọkịta, a na-atụ aro ka ọ jiri ọgwụ Lisinopril-Teva mee ọgwụ na ndị ọrịa nwere ọrịa akwara ọbara, ụbụrụ nri, n'ime oke mbelata ọbara mgbali elu nwere ike ibute infarction myocardial ma ọ bụ ọrịa strok. Ojiji nke ọgwụ Lisinopril-Teva nwere ike ibute ọrụ ezumike nkwekọ, nnukwu akụrụ renal, nke a na - agbanwe agbanwe ọbụlagodi mgbe ịkwụsị ọgwụ ahụ. Ọgwụ hypotension ọbara dị obere abụghị ọgwụ mgbochi maka ị furtherụ ọgwụ ọzọ.

N'ihe banyere stenosis nke akwara gbasara akụrụngwa (ọkachasị na stenosis nke abụọ ma ọ bụ ọnụnọ akwara nke otu akụrụ), yana yana oke mmebi akwara sitere na hyponatremia na hypovolemia, iji ọgwụ Lisinopril-Teva nwere ike bute ọrụ nsogbu gbasara akụrụngwa, nnukwu nsogbu gbasara akụrụ, ọ na - agbanwe agbanwe mgbe ọ kwụsịrị ọgwụ.

Mmekorita

Iji kpachara anya, ekwesịrị iji lisinopril mee ihe n'otu oge na potassium-sparing diuretics (spironolactone, triamteren, amiloride, eplerenone), nkwado potassium, ntụgharị nnu nke nwere potassium, cyclosporine - ịba ụba nke hyperkalemia, karịsịa na arụ ọrụ ezigharị arụmọrụ. Ya mere, ekwesịrị iji ọgwụ ndị a mee ihe naanị dabere na mkpebi otu dọkịta na-elele ya mgbe niile na -emepụta ya ọbara na ọrụ akụrụ. Iji otu oge eji ya na diuretics na ọgwụ ndị ọzọ antihypertensive, a na-eme ka mmetụta antihypertensive nke lisinopril dịkwuo mma.

N'iji NSAIDs eme ihe n'otu oge (gụnyere ndị na-egbochi cyclooxygenase-2 (COX-2) inhibitors), acetylsalicylic acid na dose nke ihe karịrị 3 g / ụbọchị, estrogens, yana kwa ọmịiko, a na-ebelata mmetụta antihypertensive nke lisinopril. Ndị NSAID, gụnyere COX-2, na ndị na-egbochi ACE na-abawanye potassium ọbara ma nwee ike imebi ọrụ akụrụ. Mmetụta a na-agbanwegharị. Lisinopril na-eji nwayọ nwayọ nke nkwadebe lithium, yabụ, n'iji n'otu oge, mmụba na-abawanye na ntinye ya na plasma ọbara, nke nwere ike ime ka ohere nke ịmalite ihe ọghọm, ya mere, a ga-enyocha nlebara anya nke lithium serum mgbe niile.

Site na iji ọgwụ antacids na colestyramine na-eme n'otu oge, ntinye nke lisinopril si eriri afọ na-ebelata.

Ajuju, azịza, nyocha banyere ọgwụ Lisinopril-Teva

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke oma banyere ogwu a di na ntuziaka ndi emeputara na nkwakọ. Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.

Kedu mgbe ewere ọgwụ jiri nlezianya mee ya?

Dịka iwu, iji nlezianya jiri "Lisinopril Teva" gosipụtara n'okwu ndị a:

• Nnukwu akwara gbasara akwara yana ọnya ọgbụgba akwara na - enwe nsogbu na azụmazụ ihe ana - eme n'ahụ mmadụ na - emegidekwa ọnọdụ ahụ mgbe enwere akụkụ ya.
• Site na hyperkalemia, stenosis nke aorta, ọbara na-egbochi ọbara ọgbụgba.
• Na-emegide nzụlite hyperaldosteronism nke mbụ, hypotension arterial na ọrịa cerebrovaskụla (gụnyere ọdịda ọbara na ụbụrụ).
• Na ọnụnọ ọnya obi, akwara na - akpata ọrịa, autoimmune systemic ọrịa nke akwara njikọ (gụnyere scleroderma, system lupus erythematosus).
• Bụrụ na mgbochi nke ụmị ọkpụkpụ.
• Na nri nwere oke nnu.
• Na - emegide usoro ọnọdụ hypovolemic n'ihi afọ ọsịsa ma ọ bụ ọria.
• N’oge agadi.

Ntụziaka maka ojiji

Mpempe akwụkwọ "Lisinopril Teva" na-eji ọnụ ekwu okwu otu ugboro n'ụbọchị, n'ụtụtụ, n'agbanyeghị nri nri, ọkacha mma n'otu oge ahụ. Na ọnụnọ nke ọbara mgbali elu, ndị ọrịa na-anabataghị ọgwụ mgbochi ọgwụ ndị ọzọ ka a na-edenye milligram 5 ugboro otu ugboro n'ụbọchị. Ọ bụrụ na enweghi mmetụta ọ bụla, usoro onunu ogwu ahụ na-ebili kwa ụbọchị atọ site na milligrams 5 ka usoro ọgwụgwọ ogo 40 milligrams (mmụba karịa nke olu a anaghị ebutekarị mgbali elu ọzọ). Ego a na-akwadokarị maka ọgwụ ahụ bụ milligram 20.

Mmetụta zuru oke, dịka iwu, na-etolite mgbe izu anọ gachara site na mmalite ọgwụgwọ, nke ekwesịrị ịtụle mgbe ị na-abawanye ụba nke ọgwụ. Na-emegide mmetụta na-ezighi ezi nke ụlọ ọgwụ, nchikota ọgwụ a na ọgwụ ndị ọzọ na - egbochi ihe mgbu. Ọ bụrụ na onye ọrịa eburula ọgwụ ịba ọcha n’anya, yabụ ojiji ha dị mkpa ịkwụsị ụbọchị atọ tupu mmalite nke "Lisinopril Teva." N'ọnọdụ nke a agaghị ekwe omume, mgbe ahụ usoro ọgwụgwọ mbụ ekwesịghị gafere milligrams 5 kwa ụbọchị. Mgbe usoro izizi nke mbụ, a na-atụ aro ka ọ rụọ ọrụ nlekọta ahụike ruo ọtụtụ awa (a na-enweta nsonaazụ kachasị mgbe ihe dị ka ọkara otu ụbọchị), n'ihi na enwere ike ịhụta mgbali elu.

Na ọnụnọ nke ọbara mgbali elu ma ọ bụ ọnọdụ ndị ọzọ nwere oke ọrụ nke sistemụ renin-aldosterone, ọ dịkwa mma ịkọwa obere ọgwụ mbido nke 5 milligrams n'okpuru nchịkwa dọkịta. Ekwesịrị ikpebi ego mmezi nke ọgwụ ahụ dabere na nrụgide nrụgide.

Na-emegide usoro mgbali elu na-adịgide adịgide, a na-egosipụta ọgwụgwọ ọgwụgwọ ogologo oge na milligrams 15 nke ọgwụ kwa ụbọchị. Na nkụda obi na-adịghị ala ala, ha na-ebu ụzọ 2.5ụọ mmiri 2.5 nwere mmụba nwayọ mgbe ụbọchị ise gachara 5 ma ọ bụ 10 milligrams. Oke kachasị kwa ụbọchị bụ milligram abụọ.

Na nnukwu myocardial infarction (dị ka akụkụ nke usoro njikọta ọgwụ), mmanya na-egbu milligram 5 n'ụbọchị mbụ, otu ahụ ka ọ gachara awa iri abụọ na anọ na iri mgbe ụbọchị abụọ gasịrị. Wee were milligram iri 10 otu ugboro n'ụbọchị. Usoro ọgwụgwọ dịkarịa ala izu isii. N'ihe banyere nrụgide dị ogologo karịa, a ga-akwụsị ị treatmentụ ọgwụ ịchọrọ.

Na-emegide nzụlite nke nephropathy na ndị ọrịa nwere ọrịa shuga 2, a na-eji milligram 10 eme otu ugboro n'ụbọchị. Ọ bụrụ na ọ dị mkpa, a ga-abawanye ọgwụ ahụ ka ọ rụọ ọrụ iri abụọ ka o wee nwee ike ị nweta nrụgide diastolic n'okpuru 75 millimeters nke mercury na ọdụ. Maka ndị ọrịa nwere ụdị oria 1, ọnụọgụ ọgwụ bụ otu.

Dodoụbiga ya ókè

Mgbaàmà nke ịdoụbiga ihe ókè bụ nkwupụta nke nrụgide yana nkụ nke mucosa ọnụ, nrụgide mmiri elektrik, mmụba ume na tachycardia. Etuputara nke a site na ntuziaka maka ojiji na nyocha. “Lisinopril Teva” nwere ike ibute mmetụta nke palpitations yana bradycardia, nkụda mmụọ, ụjọ, iwe, ụra, njide urinary, afọ ntachi, ndakpọ, hyperventilation obi.

Ọgwụgwọ ga-achọ n'ụdị gastric lavage, ojiji nke enterosorbents na laxatives. A na-egosipụta sodium chloride intraven. Ọ na-achọ nchịkwa nke nrụgide na nguzozi electrolyte. Usoro ọgwụgwọ ga - adị irè.

Ọnụ ego ọgwụ a na usoro onunu ogwu nke 10 mg dị ugbu a ihe dịka 116 rubles. Ọ dabere na mpaghara na netwọọ ahịa ọgwụ.

Analogues nke "Lisinopril Teva"

Stomi ọgwụ nke a na-enyocha bụ Diroton, Irumed, na Lysinoton. Ọ dị mkpa ịghọta na naanị dọkịta kwesịrị ịnye ọgwụ ọ bụla kama ịgachaa nke anyị kọwara.

N’okwu ha, ndị mmadụ na-ekwu na “Lisinopril Teva” bụ ezigbo ọgwụgwọ maka ọbara mgbali elu. Achọpụtara na ọ dabara adaba maka monotherapy, yana yana njikọta ọgwụ ndị ọzọ na - alụ ọgụ.

Na mgbakwunye na ịlụ ọgụ ọbara mgbali elu, ọgwụ ahụ na-enyere ndị ọrịa nwere nkụchi obi na-adịghị ala ala, yana dịka akụkụ nke ọgwụgwọ mbụ nke nkụchi obi obi.

Na nyocha nke "Lisinopril Teva" enwere mkpesa nke mmetụta ndị ọzọ n'ụdị ịsụsọ dị elu na ọdịdị nke rashes na anụ ahụ. Mana ma ọ bụghị ya, ndị ahịa na-enwe mmasị na ọgwụ a maka arụmọrụ ya na ọnụ ego dị ọnụ ala.

Mpempe usoro onunu ogwu

5 mg, 10 mg, mbadamba 20 mg

Otu mbadamba ihe

ihe nọ n'ọrụ bụ lisinopril dihydrate 5.44 mg, 10.89 mg ma ọ bụ 21.78 mg, nke lisinopril anhydrous 5 mg, 10 mg, 20 mg,

ndị mgbe ochie: mannitol, calcium hydrogen phosphate dihydrate, starch pregelatinized, pB-24823, croscarmellose sodium, magnesium stearate.

Mbadamba nkume ndị ahụ dị ọcha, gburugburu, biconvex, nwere oghere n'otu akụkụ (maka usoro nke 5 mg).

Mbadamba ụrọ ahụ bụ pink na agba, gburugburu, biconvex, nwere ihe ọghọm n'otu akụkụ (maka onunu ogwu nke 10 mg).

Mbadamba nkume ndị ahụ bụ pink, okirikiri, biconvex nwere ogbontarịrị n'otu akụkụ (maka usoro onunu ogwu nke 20 mg).

Ngwongwo ogwu

Nleta kachasị na plasma ọbara ruru ihe ruru elekere asaa mgbe nchịkwa ọnụ. Iri nri anaghị emetụta ọnụego nnabata nke lisinopril. Lisinopril anaghị ejikọ protein protein. Ihe ndị a na-etinye na ihe ndị dị ndụ na-arụ ọrụ kpamkpam na-agbanweghi site na akụrụ. Ndụ ọkara arụmọrụ bụ awa 6.6. Lisinopril na-agafe Plasenta.

Lisinopril-Teva bụ onye na-egbochi enzyme angiotensin - na - agbanwe ihe mgbochi (ACE inhibitor). Mwepu nke ACE na-eduga n'ịbelata mmebi nke angiotensin II (yana mmetụta vasoconstrictor) yana mbelata nzuzo nke aldosterone. Lisinopril-Teva na-egbochikwa mbibi bradykinin, ike vasodepressor peptide.N'ihi ya, ọ na-ebelata ọbara ọgbụgba, ngụkọta akwara akwara, ngụgụ na mgbe ebidoro obi, na-abawanye olu nkeji oge, iwepụta obi na -eme ka nnabata myocardial nwee ibu ma mekwaa ka ọbara bute n’ochemic myocardium. N'ime ndị ọrịa nwere nnukwu myocardial infarction, Lisinopril-Teva, yana nitrates, na-ebelata nguzobe nkụji aka ekpe ma ọ bụ nkụda obi.

- nkụda obi na-adịghị ala ala (dịka akụkụ nke usoro ọgwụgwọ dị mgbagwoju anya na diuretics na cardiac glycosides)

- nnukwu ọrịa myocardial infarction na ndị ọrịa nwere hemodynamics kwụ chịm na-enweghị ihe ịrịba ama nke ezughi oke akwara.

Usoro onunu ogwu na nhazi

Ọgwụgwọ kwesịrị ịmalite na 5 mg kwa ụbọchị n'ụtụtụ. Ekwesịrị ịtọ dose ahụ n'ụzọ ga - enye njikwa ọbara mgbali elu. Oge etiti oge n’etiti ịrị elu kwesịrị ịdịkarị izu atọ. Ọgwụ a na-arụkarị bụ 10-20 mg nke lisinopril 1 oge kwa ụbọchị, yana kacha sọ kwa ụbọchị bụ 40 mg 1 oge kwa ụbọchị.

Edebere Lisinopril-Teva na mgbakwunye na usoro ọgwụgwọ dị ugbu a yana diuretics na digitalis. Ọgwụ nke mbụ bụ 2.5 mg n'ụtụtụ. Ekwesịrị ịhazi usoro mmezi ya na ọkwa nke mmụba nke 2.5 mg na etiti oge nke izu 2-4. Ọgwụ a na-eme bụ 5-20 mg otu ugboro kwa ụbọchị. Eferela ọgwụ kachasị nke 35 mg nke lisinopril / ụbọchị.

Nnukwu myocardial infarction na ndị ọrịa nwere hemodynamics kwụ chịm:

Ọgwụgwọ na lisinopril-Teva nwere ike ịmalite n’ime awa iri abụọ na anọ mgbe mmalite nke mgbaàmà, nyere hemodynamics kwụsịrị (mgbali ọbara systolic karịrị 100 mmHg, na-enweghị akara nke akwara renal), na mgbakwunye na usoro ọgwụgwọ maka nkụchi obi (ndị nnọchi thrombolytic, acetylsalicylic acid, beta-blockers, nitrates). Usoro izizi bụ 5 mg, mgbe awa 24 gasịrị - 5 mg ọzọ, mgbe awa 48 gasịrị - 10 mg. Mgbe ahụ ọgwụ a bụ 10 mg nke lisinopril 1 oge kwa ụbọchị.

Ndị ọrịa nwere mgbali ọbara systolic dị ala (≤ 120 mm Hg) tupu ọgwụgwọ ma ọ bụ n'ime ụbọchị 3 mbụ mgbe nkụchi obi kwesịrị ịnata ọgwụgwọ dị ala nke 2.5 mg nke Lisinopril-Teva maka ọgwụgwọ. Ọ bụrụ na nrụgide systolic erughị 90 mm Hg. Art. kariri elekere 1 kwesịrị ịhapụ lisinopril-Teva.

Ekwesịrị ịga n'ihu maka ọgwụgwọ maka izu isii. Obere mmezi kacha nta bụ 5 mg kwa ụbọchị. Ọrịa lisinopril-Teva na-agwọ ndị ọrịa nwere ihe mgbaàmà nke nkụda obi. Enwere ike inye ọgwụ ahụ n'otu oge na nitroglycerin (intravenously ma ọ bụ n'ụdị nkwado anụ ahụ).

N'ihe banyere infarction myocardial, ekwesịrị inye lisinopril na mgbakwunye na usoro ọgwụgwọ a na-ejikarị (ndị nnọchianya thrombolytic, Acetylsalicylic acid, beta-blockers), ọkacha mma na nitrates.

N'ime ndị ọrịa merela agadi, ekwesịrị idozi usoro ọgwụgwọ ahụ na-eburu n'uche nke creatinine (iji chọpụta ọrụ akụrụ), nke usoro Cockroft na-agbakọ:

Iri afọ (140)

0.814 × serin creatinine (μmol / L)

(Maka ụmụ nwanyị, nsonaazụ enwetara site n'ụkpụrụ a kwesịrị ka amụba site na 0.85).

Usoro onunu ogwu na ndi oria na aru oru ya na oke ubara ya (nyefee nwuta 30 - 70 ml / min):

Usoro izizi bụ 2.5 mg n'ụtụtụ, oge mmezi bụ 5-10 mg kwa ụbọchị. Kariri ogo nke 20 mg nke lisinopril kwa ụbọchị.

Enwere ike iwere Lisinopril-Teva n'agbanyeghị nri, mana enwere nnukwu mmiri mmiri, 1 oge kwa ụbọchị, ọkacha mma n'otu oge ahụ.

Mkparịta ụka ọgwụ ọjọọ

Site n'iji mbadamba ụrọ Lisinopril-Teva na:

- Enwere ike belata lithium excretion site n'ahụ ya, yabụ, ọ dị mkpa iji nlezianya nyochaa mkpokọta lithium na ọbara ọbara.

- analgesics, ọgwụ mgbochi mkpali na - abụghị steroidal (dịka ọmụmaatụ, acetylsalicylic acid, indomethacin) - ọ ga - ekwe omume ịbelata mmetụta hypoensive nke lisinopril.

- baclofen - enwere ike ịkwalite utịpị hypotensive nke lisinopril-diuretics - ọ ga - ekwe omume ịbawanye ike nke lisinopril.

-A na-eme ka ọnụọgụ potassium na-enye ọnya (spironolactone, triamteren ma ọ bụ amiloride) na mgbakwunye potassium na-eme ka ohere nke hyperkalemia dịkwuo elu.

ọgwụ antihypertensive - nwere ike ịkwalite mmetụta hyisensive nke lisinopril

- ọgwụ mgbochi, ọgwụ, ọgwụ ụra - ikekwe mbelata nke ọbara mgbali elu

- allopurinol, cytostatics, immunosuppressants, corticosteroids systemic, procainamide - ihe egwu nke imepe leukopenia na-abawanye

- ọgwụ antidiabetic ọgwụ (nke dị n'ụkpụrụ sulfonylurea, biguanides) na insulin - ọ ga - ekwe omume iwelie mmetụta hypotensive, karịsịa na izu mbụ nke ọgwụgwọ njikọta.

- amifostine - enwere ike ịbawanye hypotensive

- antacids - belata bioavailability nke lisinopril

- sympathomimetics - hypotensive uto nwere ike ịbawanyewanye

- mmanya - ikekwe ị ofụ mmanya bara ụba

- sodium chloride - adịghị ike nke mmetụta hyisensive nke lisinopril na ọdịdị nke ihe mgbaàmà nke nkụda obi.

Mpempe mwepụta

Ọgwụ dị n'ụdị mbadamba. N'agbanyeghị ntinye uche, ha dị n'ụdị biconvex oval na agba ọcha. Enwere ihe ọghọm dị n'otu akụkụ nke ọgwụ, n'akụkụ nke ọzọ bụ ihe osise “LSN2.5 (5, 10, 20)”.

Njirimara nke mmejuputa a dabere na ntinye uche nke ihe na-eme ihe n'ime ogwu. Na agbanyeghị ihe a, ekwesịrị mbadamba ihe ndị a na paịlị 10. Na usoro onunu ogwu nke 2.5 mg, a na-etinye 3 ụdị efere n'otu ngwungwu, 5 mg - 1 ma ọ bụ 3 iberibe. A na-ere mkpụrụ ọgwụ 10 na 20 mg na blisters 1, 2 ma ọ bụ 3 kwa otu.

Iji ọgwụ ọjọọ eme ihe

Lisinopril na - egbochi enzyme angiotensin na - agbanwe, nke bụ ihe na - akpata nkwụsị nke angiotensin I rue angiotensin II. N'ihi ya, a na-ebelata njikọta aldosterone na mgbochi akwara olu, yana ịmụrụ prostaglandin. Mmetụta a na-eduga n'ịbelata ọbara mgbali elu, nrụgide na akwara nke akpa ume na mbubata mbido, mmụba nke olu nkeji.

Theakingụ ọgwụ ahụ na-eme ka ọkpụkpụ obi nwere ike ịmịnye mmadụ ọbara. Ọgwụ ogologo oge nwere ike belata myocardial hypertrophy. N'ime ndị ọrịa nwere ọrịa obi na-adịghị ala ala, ogologo ndụ na-abawanye. Ọ bụrụ na enwere nkụchi obi ọgụ, mana anaghị egosipụta ọghọm nke ọgwụ, mgbe ahụ ị useụ ọgwụ, ọny ụsọ mmụọ aka ekpe ji nwayọ nwayọ.

N’ụbọchị mbụ nke ọgwụgwọ, a na-ahụta mmetụta hypotensive nke ọgwụ ahụ. Ọ na-eru nkwụsi ike n'ime ọnwa 1-2 nke ị theụ ọgwụ mgbe niile.

Okwesiri iburu n'uche na ụfọdụ ọrịa nwere ike imetụta ọgwụ nke ọgwụ:

• mbelata, mkpofu na bioavailability (16%) n'ihu ọnya obi na-adịghị ala ala,
• mụbara mgbe ụfọdụ ịta lisinopril na plasma na ọdịda akụrụ,
• Ibelata plasma ugboro 2 n'oge agadi,
• 30% belata na bioavailability na mkpochapụ 50% megide cirrhosis.

Mmetụta ọghọm, ịdoụbiga ya ókè

Mmeghachi omume na-adịghị mma mgbe ị na-ewere Lisinopril-Teva na-ekewa n'ime otu dị ka oge ngosipụta ha. Ọtụtụ mgbe, ụdị ọgwụgwọ ahụ na-eduga nsonaazụ ndị a:

• orthostatic hypotension,
• kpọpụtara nrụgide,
• Anya isi, isi ọwụwa,
• ụkwara
• vomiting
• afọ ọsịsa
• arụ ọrụ ezumike.

O kwesịrị ka onye okacha mara họrọ usoro ọgwụgwọ ya. N'ihe banyere usoro ejiri ahọrọ nke ọma ma ọ bụ karịa na akwadoro olu, enwere ike ọtụtụ nsonaazụ mmetụta.

Ọtụtụ mgbe, ịdoụbiga mmanya ókè na-egosi site na mgbaàmà ndị a:

• mgbali mgbali elu,
• ọnụ kpọrọ nkụ
• mmiri eleghara anya,
• gbasara akwara
• iku ume ngwa ngwa
• palpitations
• anya ntughari
• nchegbu
• ụba oke iwe
• iro ụra
• bradycardia
• ụkwara
• njigide urinary
• afọ ntachi
• hyperventilation nke ngụgụ.

Enweghị ọgwụ mgbochi akọwapụtara maka ọgwụgwọ nke ịdoụbiga mmanya ókè. Ọ dị mkpa ịsụ nsị ahụ, iji hụ na mmiri nke enterosorbent na laxative. Usoro ọgwụgwọ ahụ gụnyekwara ọgwụ nnu n'ime. Ọ bụrụ na bradycardia na-eguzogide ọgwụgwọ, gaa ịwụnye pacemaker. Jiri usoro hemodialysis rụọ ọrụ nke ọma.

Ndakọrịta na ọgwụ ndị ọzọ, mmanya

O kwere omume na usoro nke lisinopril na-eji ọgwụ ọgbụgba oge ma ọ bụ nlekọta nke ọgwụ antihypertensive ndị ọzọ. Vasodila etinyere, barbiturates, tricyclic antidepressants, ndị na-emegide calcium, β-blockers nwere ike ibute nsonaazụ yiri ya. A na-ahụta nsonaazụ nke ọzọ mgbe ejikọtara ya na acetylsalicylic acid, sympathomimetics, estrogens ma ọ bụ ọgwụ nke otu na-emegide steroidal anti-inflammatory.

Nlekọta nke Lisinopril-Teva na-emekọ ihe ọnụ na nhazi nke potassium ma ọ bụ nkwado potassium nwere ike ibute hyperkalemia. Njikọ ya na insulin ma ọ bụ onye na-ahụ maka hypoglycemic nwere ike ibute hyperglycemia.

Mmanya na-egbu egbu ma ọ bụ ọgwụ nwere ethanol na-eme ka mmetụta nke lisinopril pụta.

Ndụ shelf, ọnọdụ nchekwa

Ichekwa ọgwụ a ga-ebu ụzọ rute ụmụaka na-enweghị ogo ogo ogo 25. Ọ bụrụ na ezute ọnọdụ a, enwere ike iji ọgwụ ahụ mee ihe n'ime afọ 2 site na ụbọchị nke emepụtara ya.

Ọnụ ego dị n'otu mkpọ Lisinopril-Teva 2.5 mg ma ọ bụ 5 mg bụ 125 rubles. Ọgwụ 10 mg na-efu nkezi nke 120 rubles maka mbakara 20 na 135 rubles maka iberibe 30. Otu ọgwụ ọgwụ 20 mg ga-efu ihe dịka 150 rubles maka mbadamba 20 na 190 rubles maka ọgwụ 30.

Purchasezụta, ịkwesịrị inye dọkịta ọgwụ ọgwụ dọkịta.

Lisinopril-Teva nwere ọtụtụ analogues. Ha nile dabere na otu ihe eji arụ ọrụ - lisinopril. Ọgwụ ndị a gụnyere:

• Aurolyza,
• Diroton
• Egburu
• Vitopril
• Lysoryl
• Lizi Sandoz,
• Zonixem
• Lysinokol
• Lisopril
• Dapril
• Lysigamma
• Scopril
• Mkpesa
• Lisighexal
• Solipril
• Linotor.

Lisinopril-Teva na - egbochi enzyme angiotensin-na - agbanwe mmetụta dị mgbagwoju anya. Were ọgwụ a kwesịrị ka dọkịta dechaa ya n’otu olu akọwapụtara, ma ọ bụrụ na ị doụbiga ya ókè. Mgbe ejikọtara ya na ọgwụ ndị ọzọ, ike nke lisinopril nwere ike ịdị iche.

Andzọ na atụmatụ ngwa

A na-eji ọgwụ ahụ Lisinopril-Teva eme ihe site na ilo ilo ọgwụ ndị chọrọ ka ọ bụrụ ọgwụ ọ bụla ga-ezu ezu. Bọchị a na -eme kwa ụbọchị bụ otu mbadamba, nke a ga-eripịa n’oge a na-agwọ ya otu ugboro n’ụbọchị, n’otu oge ahụ, na-ebughị n’obi iri nri. Ọ bụ dọkịta na-abịa ihe niile ka ahọpụtara usoro onunu ogwu ọ bụla.