Mpempe akwụkwọ analog glibenclamide

Hypoglycemia (nke megidere usoro ị regụ ọgwụ na nri ezughị oke), oke ibu, ahụ ọkụ, ọrịa arthralgia, proteinuria, mmeghachi omume nfụkasị (ọnya anụ ahụ, itching), dyspepsia (ọgbụgbọ, afọ ọsịsa, mmetụta nke oke ibu na epigastrium), nsogbu akwara ozi (paresis, ọrịa uche) , hemopoiesis (hypoplastic ma ọ bụ hemolytic anaemia, leukopenia, agranulocytosis, pancytopenia, eosinophilia, thrombocytopenia), arụ ọrụ imeju (cholestasis), mbubreyo cutaneous porphyria, mgbanwe na uto, polyuria, foto ensibilizatsiya, isi ọwụwa, ike ọgwụgwụ, adịghị ike, dizziness.

Ngwa na usoro onunu ogwu

Ọgwụ a na-adabere na afọ, ogo nke ọrịa shuga, ịta nke glucose ọbara na-ebu ọnụ na awa 2 mgbe ị risịrị nri. Ogologo ubochi ubochi sitere na 2.5 ruo 15 mg. Oge nchịkwa dị ugboro 1-3 kwa ụbọchị maka nkeji 20-30 tupu eri. Usoro onyonye ihe kariri 15 mg / ụbọchị anaghị ebido ogo mmetụta hypoglycemic. Ọgwụ izizi n’ebe ndị ọrịa agadi dị 1 mg / ụbọchị.

Mgbe ị na-eji ụdị ọrụ a dochie ọgwụ hypoglycemic, glibenclamide ka edepụtara dịka atụmatụ dị n’elu, a na-akwụsị ị canceụ ọgwụ ochie. Mgbe ị na-agbanwe site na biguanides, usoro mbụ kwa ụbọchị bụ 2.5 mg, ọ bụrụ na ọ dị mkpa, a na-amụba kwa ụbọchị kwa ụbọchị 5-6 site na 2.5 mg ruo mgbe a ga-akwụ ụgwọ ụgwọ. Na enweghị ụgwọ n'ime izu 4-6, ọ dị mkpa ikpebi na usoro njikọta ọgwụ.

Ntụziaka pụrụ iche

Ọ dị mkpa ilebara ọkwa glucose anya mgbe niile n'ọbara na afọ efu na mgbe ị risịrị nri, usoro ụbọchị niile nke ọdịnaya glucose n'ọbara na mmamịrị.

N'ihe banyere usoro ịwa ahụ ma ọ bụ oria shuga, enwere ike ịtụle iji insulin eme ihe.

E kwesiri ịdọ ndị ọrịa aka na ntị gbasara ịba ụba hypoglycemia n'ihe banyere ethanol oriri (gụnyere mmepe nke mmeghachi omume disulfiram-: mgbu afọ, ọgbụgbọ, ọgbụgbọ, isi ọwụwa), NSAIDs, na agụụ.

N'oge ọgwụgwọ, a naghị atụ aro ka ọ nọrọ n’anyanwụ ogologo oge.

Imeghari otu ọ̀ dị mkpa maka ịghara oke nri anụ ahụ na nke mmetụta uche, mgbanwe nri.

A ga-ekpuchi ngosipụta nke ọrịa hypoglycemia mgbe ị na-ewere beta-blockers, clonidine, reserpine, guanethidine.

N'oge usoro ọgwụgwọ, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike ịdị ize ndụ chọrọ mgbanye uche na ọsọ nke mmeghachi omume psychomotor.

Mmekorita

ACE inhibitors (captopril, enalapril), H2-histamine receptor blockers (cimetidine), ọgwụ antifungal (miconazole, fluconazole), NSAIDs (phenylbutazone, azapropazone, oxyphenbutazone), fibrates (clofibrate, ọgwụ anti-agonamides, anti-agonamides anti, usoro, anabolic steroid, beta-mgbochi, MAO inhibitors, sulfonamides na-eme ogologo oge, cyclophosphamides, biguanides, chloramphenicol, fenfluramine, acarbose, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubule blockers oh secretion, reserpine, bromocriptine, disopyramide, pyridoxine, insulin, allopurinol welie mmetụta.

Barbiturates, corticosteroids, adrenostimulants (epinephrine, clonidine), ọgwụ antiepileptik (phenytoin), BMKK, carbonic anhydrase inhibitors (acetazolamide), thiazide diuretics, chlortalidone, furosemide, triamterene isinazinazinazinazina bụ ndị na-adịghị ike. salbutamol, terbutaline, glucagon, rifampicin, homonụ thyroid, Li + nnu, na oke ọnụọgụ - nicotinic acid, chlorpromazine, mgbochi ogwu na ọgwụ.

Idnweta ọgwụ mmamịrị (ammonium chloride, CaCl2, ascorbic acid na nnukwu usoro) na-eme ka mmetụta ahụ dịkwuo elu site na ibelata ogo nke dissociation na ịba ụba reabsorption nke glibenclamide.

Ọgwụ ndị na-egbochi ụmị ọkpụkpụ, na-eme ka ihe myelosuppression dịkwuo elu.

Diabetologist: "Ka imezi ọkwa shuga dị n'ọbara."

Analogs nke ọgwụ Glibenclamide

Ihe atụnyere dị oke ọnụ karịa 145 rubles.

Emeputa: Onye na-ere ọgwụ (Russia)
Mwepụta Mwepụta:

• Tab. 2 mg, 30 PC., Ọnụ ahịa site na 191 rubles
• Tab. 3 mg, 30 PC., Ọnụ ahịa site na 272 rubles

Ọnụ ahịa Glimepiride na ụlọ ahịa ọgwụ dị n'ịntanetị
Ntụziaka maka ojiji

Glimepiride bụ ọgwụ ụlọ maka ịgwọ ụdị ọrịa shuga 2. Ọ dị n'ụdị mbadamba nkume nwere ihe dị otu arụ ọrụ n'ime usoro nke 2 ruo 4 mg kwa mbadamba.

Ihe analog ahụ dị ọnụ karịa 82 rubles.

Emeputa: A na-akọwa
Mwepụta Mwepụta:

• Tab. ya na MV 30 mg, 30 PC., Ọnụ ahịa site na 128 rubles
• Tab. 3 mg, 30 PC., Ọnụ ahịa site na 272 rubles

Diabetalong na ahịa ọgwụ dị n'ịntanetị
Ntụziaka maka ojiji

Diabetalong bụ ọgwụ mbadamba ọgwụ maka ịgwọ ụdị ọrịa shuga dị n'ọrịa 2 nke gliclazide dị na 30 mg. Edebere ọgwụ ahụ na arụmọrụ arụ yana nri adịghị ezu. Enwere ọgwụ mgbochi na mmetụta ọ na-akpata.

Ihe analog si dị ọnụ karịa 73 rubles.

Emeputa: Akrikhin (Russia)
Mwepụta Mwepụta:

• Mbadamba 80 mg, 60 PC., Ọnụ sitere na 119 rubles
• Tab. 3 mg, 30 PC., Ọnụ ahịa site na 272 rubles

Ọnụ ahịa Glidiab n'ụlọ ahịa ọgwụ dị n'ịntanetị
Ntụziaka maka ojiji

Glidiab bụ otu n'ime ndị bara uru dochie anya gliclazide. E nwekwara ya n'ụdị mbadamba, mana usoro nke DV dị elu ebe a, nke a ga-elebara anya tupu ịmalite ọgwụgwọ. E gosipụtara ya maka ụdị ọrịa shuga withdị nke 2 na nri adịghị arụ ọrụ na mmega ahụ.

Ihe atụnyere dị oke ọnụ karịa 83 rubles.

Emeputa: Farmakor (Russia)
Mwepụta Mwepụta:

• Mbadamba ụrọ 30 mg, 60 PC., Ọnụahịa site na 129 rubles
• Tab. 3 mg, 30 PC., Ọnụ ahịa site na 272 rubles

Diabefarm MV na-ere ọgwụ n'ịntanetị
Ntụziaka maka ojiji

Akrikhin (Russia) Glidiab bụ otu n'ime ndị bara uru dochie anya gliclazide. E nwekwara ya n'ụdị mbadamba, mana usoro nke DV dị elu ebe a, nke a ga-elebara anya tupu ịmalite ọgwụgwọ. E gosipụtara ya maka ụdị ọrịa shuga withdị nke 2 na nri adịghị arụ ọrụ na mmega ahụ.

Ihe atụnyere dị oke ọnụ karịa 81 rubles.

Emeputa: A na-akọwa
Mwepụta Mwepụta:

• Mbadamba ụrọ 30 mg, 60 PC., Ọnụahịa site na 127 rubles
• Tab. 3 mg, 30 PC., Ọnụ ahịa site na 272 rubles

Ọnụ ahịa Gliclazide MV n'ụlọ ahịa ọgwụ dị n'ịntanetị
Ntụziaka maka ojiji

Gliclazide MV bụ mbadamba mbadamba maka ọgwụgwọ nke ụdị ọrịa shuga mellitus nke 2 dabere na otu ihe ahụ na - arụ ọrụ na usoro nke 30 mg. Edere ya maka nri adịghị mma na mmega ahụ. A na-egbochi ndị mmadụ Gliclazide MV n'ime ndị ọrịa nwere ọrịa shuga 1 (insulin-based).

Ihe analogue dị ọnụ karịa 263 rubles.

Emeputa: Sanofi-Aventis S.p.A. ()Tali)
Mwepụta Mwepụta:

• Tab. 1 mg, 30 PC., Ọnụ ahịa site na 309 rubles
• Tab. 2 mg, 30 PC., Ọnụahịa site na 539 rubles

Ọnụ ahịa Amaryl na ụlọ ahịa ọgwụ dị n'ịntanetị
Ntụziaka maka ojiji

Amaryl bụ ọgwụgwọ maka ụdị shuga 2 n'ụdị mbadamba nkume ezubere maka ojiji nke ime. Dị ka ihe na-arụ ọrụ, a na-eji glimepiride na usoro nke 1 ruo 4 mg. Enwere ọgwụ mgbochi na mmetụta ọ na-akpata.

Ihe analog si dị ọnụ karịa 93 rubles.

Emeputa: Berlin-Chemie / Menarini Pharma (Germany)
Mwepụta Mwepụta:

• Mpempe 5 mg, pọọpu 120., Ọnụ ahịa site na 139 rubles
• Tab. 2 mg, 30 PC., Ọnụahịa site na 539 rubles

Ahịa maka Maninil 5 na ụlọ ahịa ọgwụ dị n'ịntanetị
Ntụziaka maka ojiji

Ọgwụ mbadamba ọgwụ maka ịgwọ ọrịa shuga dabere na glibenclamide (n'ụdị micronized) na usoro onunu ogwu nke 1.75 mg. E gosipụtara ya maka iji ụdị ọrịa shuga ụdị ọrịa shuga 2 (na adịghị ike nke nri siri ike).

Ihe atụnyere dị ọnụ ọnụ karịa 140 rubles.

Emeputa: Canonpharma (Russia)
Mwepụta Mwepụta:

• Tab. 2 mg, 30 PC., Ọnụ ahịa site na 186 rubles
• Tab. 4 mg, 30 PC., Ọnụ ego site na 252 rubles

Canon glimepiride ọnụ ahịa na ahịa ọgwụ dị n'ịntanetị
Ntụziaka maka ojiji

Glimepiride Canon bụ otu n'ime ọgwụ kachasị baa uru maka ịgwọ ụdị ọrịa shuga mellitus nke 2 dabere na glimepiride na usoro ọgwụgwọ. Edere ya maka enweghi ike iri nri na mmega ahụ.

Ihe analogue dị ọnụ karịa 164 rubles.

Emeputa: Akrikhin (Russia)
Mwepụta Mwepụta:

• Tab. 1 mg, 30 PC., Ọnụ ahịa site na 210 rubles
• Tab. 2 mg, 30 PC., Ọnụahịa site na 319 rubles

Ọnụ ahịa ọla kọpa na ụlọ ahịa dị n'ịntanetị
Ntụziaka maka ojiji

Canonpharma (Russia) Glimepiride Canon bụ otu n'ime ọgwụ kachasị baa uru maka ọgwụgwọ nke ọrịa shuga ụdị ọrịa shuga 2 nke glimepiride na usoro ọgwụgwọ yiri ya. Edere ya maka enweghi ike iri nri na mmega ahụ.

Ihe analogue dị ọnụ karịa 256 rubles.

Emeputa: Krka (Slovenia)
Mwepụta Mwepụta:

• Mbadamba 60 mg, 30 PC., Ọnụahịa site na 302 rubles
• Tab. 2 mg, 30 PC., Ọnụahịa site na 319 rubles

Ọnụ ahịa Gliclada n'ụlọ ahịa ọgwụ n'ịntanetị
Ntụziaka maka ojiji

Nkwadebe mbadamba Slovenian maka ọgwụgwọ nke ọrịa shuga 2. Dị ka ihe na-arụ ọrụ, a na-eji gliclazide na usoro nke 30 ma ọ bụ 60 mg kwa mbadamba. Enwere ọgwụ mgbochi na mmetụta ndị ọ na-akpata.

Ntụnyere dị ọnụ karịa 350 rubles.

Emeputa: Beringer Ingelheim International GmbH (Germany)
Mwepụta Mwepụta:

• Tab. 30 mg, 60 PC., Ọnụahịa site na 396 rubles
• Tab. 2 mg, 30 PC., Ọnụahịa site na 319 rubles

Ọnụ ahịa glurenorm na ụlọ ahịa ọgwụ dị n'ịntanetị
Ntụziaka maka ojiji

Glurenorm bụ nkwadebe mbadamba maka ọgwụgwọ nke ụdị shuga mellitus 2 dị na glycidone na usoro nke 30 mg. Contraindicated n'ụdị 1 ọrịa shuga, lactation, ịtụrụ ime, imeju na ọrịa akụrụ. Enwere ike ịchọta ndepụta zuru oke nke contraindications na ntuziaka ahụ.

Ngwakọta, nkwakọ ngwaahịa, ụdị ntọhapụ

Kedu ụdị ọgwụ a na-eme "Glibenclamide"? Akwụkwọ ntuziaka na-akọ na ngwaahịa a dị n'ụdị mbadamba ndị etinyebere n'ime akpa plastik (mkpụrụ ndụ contour) na igbe kaadiboodu, karị.

Ihe mejupụtara ọgwụ a na ajụjụ ahụ gụnyere 5 mg nke glibenclamide, yana ihe ndị ọzọ na-enye aka dị ka stachi nduku, lactose monohydrate, magnesium stearate, croscarmellose sodium, indigo carmine E 132, colloidal silicon dioxide na povidone 25.

Iji ọgwụ ọjọọ eme ihe

Gini bu ogwu "Glibenclamide"? Ntụziaka maka ojiji na-ekwupụta na nke a bụ mmetụta hypoglycemic n'ahụ ndị mmadụ na ndị ọrịa nwere ụdị shuga 2.

Ofdị irè nke ọgwụ a bụ n'ihi ike ya ịbawanye ụba insulin site na mkpụrụ ndụ beta nke pancreas n'ihi mkpali ha. Dika ndi okacha mara si kwuo, mmetuta ogwu a na - eme ka enwekwukwa ike mmanu.

Atụmatụ Kinetic nke ọgwụ ọgwụ

Ihe njirimara nke pharmacokinetic bu ihe emere maka ogwu Glibenclamide? Ntụziaka eji eme ihe na-ekwu na mgbe mbadamba ụrọ nke ejiri akara, ihe ha na-arụ ọrụ ngwa ngwa ma ọ fọrọ nke nta ka ọ banye kpamkpam na ngọngọ nri.

Oge nri na-eme n'otu oge na-eduga n'ịbelata mkpokọta nke glibenclamide na plasma ọbara (ma e jiri ya na-ebu ọnụ). Njikọ nke akụkụ a na albumin karịrị 98%.

N'ime imeju onye ọrịa, a gbanwere glibenclamide n'ime metabolites ndị a: 3-cis-hydroxy-glibenclamide na 4-trans-hydroxy-glibenclamide. A na-ekewa ha n'otu aka ahụ akụrụ yana feces.

Nkezi ọgwụ ọkara ọkara bụ awa 2-3.5. N'ime ndị nwere ọrụ imeju na-ebelata, ihe ngosi a belatara nke ọma.

Amachibido iji

Enwere ọgwụ mgbochi ọ bụla maka Glibenclamide? Ntuziaka maka iji na-ekwu na ekwesighi inye ndị ọrịa nwere ọgwụ a:

• oke oku
• hypersensitivity na ihe nọ n'ọrụ, yana thiazide diuretics ma ọ bụ sulfonamides,
• ketoacidosis,
• ọrịa mamịrị na preatotous ọnọdụ
• mmepe nke hypoglycemia,
• ịwa ahụ na mmerụ ahụ ndị ọzọ,
• paresis nke afọ na eriri afọ mgbochi,
• tụụrụ ime
• ụdị shuga 1
• inye ara.

Ọgwụ "Glibenclamide": ntuziaka maka ojiji

Ọgwụ ọ nwere ajụjụ kwesịrị ka ọ bụrụ dọkịta doro anya ga-edenye ya. Iwere ọgwụ a kwesiri ijikọ ya na nri siri ike. Naanị na nke a ka ọ ga-adị irè. Usoro usoro usoro onunu ogwu dabere na nsonaazụ nyocha nke onye ọrịa (shuga ọbara, ihe ndị egosipụtara enwetara site na nyocha nke mmamịrị, wdg).

Yabụ kedu ka ị ga - esi were ọgwụ “Glibenclamide”? Usoro ọgwụgwọ a nwere usoro amalite site na obere doses. Nke a bụ eziokwu bụ eziokwu maka ndị nwere ọrịa hypoglycemia na ịdị arọ anụ ahụ erughị kilogram 50.

Dị ka ọ dị, usoro ị ofụ ọgwụ mbụ bụ mbadamba 0.5-1 kwa ụbọchị. Nke a kwekọrọ na 2.5-5 mg nke ihe na-arụ ọrụ. Site na mmetụta adịghị mma nke ọgwụ ahụ, enwere ike ịba ụba nke ego ahụ gosipụtara ka ọ bụrụ mbadamba atọ kwa ụbọchị, nke kwekọrọ na 15 mg nke ihe ndị na-arụ ọrụ. Ekwesịrị ime nke a site na oge ruo ọtụtụ ụbọchị ruo otu izu ruo mgbe a rụpụtara ihe achọrọ.

Etu esi ebufe onye ọrịa site na ọgwụ ọzọ na ọgwụ Glibenclamide? Ojiji nke ọgwụ n’okwu a ga-eme nke ọma. Nke mbu, a na-enye onye ọrịa ahụ mbadamba mbadamba 0,5 kwa ụbọchị, mgbe ahụ, a na-eji nwayọọ nwayọọ mụbaa ọgwụ ahụ ruo n’ọrụ kachasị arụ ọrụ.

Maka ndị agadi, yana ndị ọrịa nwere nkwarụ ma ọ bụ ndị ọrịa na-ezighi ezi nri na imeju ma ọ bụ ọrụ akụrụ, ọ ga-adị mma ka ịbelata mmezi ma ọ bụ usoro ị initialụ ọgwụ ọgwụ ahụ ruo oge o kwere mee n'ihi mmepe nke hypoglycemia. Ọzọkwa, a ga-elebara ajụjụ banyere ịhazigharị ọgwụ ole ọ whenụrụ ọgwụ ya mgbe ogo ahụ onye ọrịa belatara ma ọ bụ mgbe ụzọ ndụ ya na-agbanwe agbanwe.

Ofzọ isi were mbadamba hypoglycemic

Etu esi eji Glibenclamide? Ntuziaka maka ojiji (foto nke ọgwụ a ka egosiri n’edemede a) na-ekwu na a ga-ebu mbadamba ihe a chọrọ n’ihu tupu e rie nri, were iko mmiri a gbanyere wee sachaa ya.

Site na iji usoro onunu ogwu 2 kwa ubochi, a na-atụ aro ka ọgwụ ahụ kee usoro abụọ (n'ụtụtụ na mgbede) na 2: 1.

Ọ dị mkpa iji ọgwụ a n'otu oge. Ọ bụrụ na iyịre ọgwụ a, ekwesighi iburu mbadamba ya na nke ọzọ.

Ogologo oge ọgwụgwọ ya na ọgwụ a dabere na ọrịa ahụ. N'ime oge ọgwụgwọ, achọrọ ileba anya na metabolic steeti onye ọrịa.

Nsonaazụ

Ọgwụ "Glibenclamide", analogues nke edepụtara n'okpuru, nwere ike ibute mmepe nke mmeghachi omume na-emetụta ụjọ, endocrine, akụkụ na nri nri, yana hematopoietic. N'akụkụ a, onye ọrịa ahụ nwere ike ịnwe nsonaazụ ndị ọzọ dị ka ọgbụgbọ, hypoglycemia nke ịdị iche iche, ọrụ imeju na-arịa, afọ ọsịsa, isi ọwụwa, cholestasis, adịghị ike, dizzness na ike ọgwụgwụ.

Okwesiri iburu n’uche n’ebido ị takingụ ọgwụ a, ọdịdị nke akpịrị ịkpọ ụzụ na mmeghachi ahụ nfụkasị ụdị fotoensitivity, itching, nchacha akpụkpọ na ihe ịrịba ama ndị ọzọ adịghị mma.

Hypoglycemic overdose

Kedu ihe mgbaàmà na-apụta mgbe ị na-a highụ ọgwụ dị elu "Glibenclamide"? Ntụziaka ahụ na-ekwu na site doụbiga ya ókè, onye ọrịa ahụ nwere ike ịmalite hypoglycemia, ikekwe yana ike ọgwụgwụ, agụụ, isi ọwụwa, nchekasị, ọsụsọ, oke ibu, ịma jijiji, palpitations, akụkụ ụbụrụ, ahụhụ na nsogbu okwu.

Ọgwụgwọ nke ọnọdụ ndị dị otú a gụnyere nchịkwa ngwa ngwa nke ngwaahịa nwere glucose nwere ngwa ngwa. Dịka ọmụmaatụ, ihe ọ fruitụ fruitụ mkpụrụ osisi, shuga, ọka sirop, tii dị ụtọ ma ọ bụ mmanụ a honeyụ.

N'okwu ndị ka njọ, a na-eji ọgwụ glucose 50%, Dextrose, Glucagon ma ọ bụ Diazoxide were onye ọrịa ahụ. Achọkwara njikwa pụrụ iche nke glycemia, creatinine, urea nitrogen, electrolytes na pH kpebisiri ike.

Ozi puru iche

A ga-eji nnabata hypoglycemic na-atụle ga-akpachara anya na ndị ọrịa na-ata ahụhụ site na akụrụ na hepatic dysfunction, yana ọrụ pathologies nke thyroid na ọrịa adrenal, ọnọdụ febrile na egbu egbu na-egbu egbu.

Maka usoro ọgwụgwọ kwesịrị ka a na-enyocha ọkwa glucose n'ọbara onye ọrịa, yana mwepụ ya.

Ọ bụrụ na onye ọrịa ahụ tolitere hypoglycemia mgbe ọ na-a theụ ọgwụ, mgbe ahụ ka etinyere shuga n'ime (ọ bụrụ na onye ahụ maara). Ọ bụrụ na amataghị mmụọ, a na-eduzi glucose ọbara, a na-ejikwa glucagon subcutaneously, intramuscularly ma ọ bụ intravenously. Mgbe onye ọrịa nwetasịrị onwe ya, ha na-enye ya nri nri nwere nnukwu carbohydrates ozugbo iji zere ịmaliteghachi hypoglycemia.

Akwụ ụgwọ na analogues (synonymousms) nke ego

Họrọ analogues nke ọgwụ a kwesịrị ịbụ naanị ọkachamara nwere ahụmahụ. Ndị dọkịta na-ekwu maka ọgwụ ndị a: "Maninil", "Manin", "Maniglide", "Betanaz" na "Antibet".

Okwesiri iburu n’uche na n’ụlọ ahịa ọgwụ mgbe mgbe ha na-erekarị ọgwụ maka ọgwụ a. Ọtụtụ mgbe a na-eji ha dị ka: Glidanil, Glibex, Glibamide, Gilemal, Glibomet, Glibenclamide. A na-ahọrọ usoro onodu ego ndị a n'otu n'otu.

Maka ọnụahịa ọgwụ "Glibenclamide", ọ dịgasị n'etiti 280-360 rubles.

Nyocha Ọgwụ

Ugbu a ị maara ihe ọgwụ "Glibenclamide" bụ. Ntuziaka maka ojiji, analogues na ụdị mwepụta nke onye nnọchi anya a kọwara n’elu.

Kedu ihe ndị na-azụ ahịa na-ekwu maka ọgwụ a? Dịka iwu, akụkọ niile gbasara ya na-agbadata na mkparịta ụka nke usoro ọgwụgwọ ụfọdụ ka akwadoro maka ndị nwere ọrịa shuga.

Ndị na-azụ ahịa na-ekwu na ọtụtụ mgbe ha na-eji Glibenclamide dị ka monotherapy. Agbanyeghi na enwere ndi oria ahu ndi ederoro ogwu ahu na ọgwụ ndi hypoglycemic.

Dabere na ndị dọkịta, nhọpụta nke ọgwụ a na-enyocha chọrọ mmadụ iji ya mee ihe. N'okwu a, ọkachamara ahụ kwesịrị ịmara nsonaazụ niile nke nyocha na ọmụmụ ndị ọzọ. Takega "Glibenclamide" nye ndị ọrịa n'echiche ha dị oke egwu maka ahụike na ndụ.

Ihe ndị a na-ahụ maka ọgwụ nke glibenclamide

Glibenclamide nwere mmetụta hypocholesterolemic na hypoglycemic n'ahụ mmadụ.

Ihe na-arụ ọrụ bụ glibenclamide. Ngwa inye aka bụ lactose monohydrate, nduku ma ọ bụ ahịhịa ọka, shịum croscarmellose, povidone 25, magnesium stearate, indigo carmine na aerosil.

Dịka ntuziaka ahụ si dị, Glibenclamide nwere mmetụta mkpali kpọmkwem na mkpụrụ ndụ beta nke ngwa islet, ma na - emetụta ọnụnọ ọgwụ insulin. A na-egosipụta ọrụ ọgwụ ahụ ka ọ na-edozi ọrụ insulin-sịntetik nke pancreas. Ngwá ọrụ ahụ na-enyere aka weghachite uche anụ ahụ nke sel beta mebiri glycemic.

Ọgwụ a na -eme ka mmetụta insulin na nke endogenous na-eweta site na ịbawanye ọnụ ọgụgụ ndị na-anabata insulin, na-akpali mmụba nke mmekọrịta insulin-receptor na njikọ nke mweghachi nke nnyefe ihe nnabata post-receptor.

Mmụba plasma na mkpokọta insulin na mbelata glucose adịghị ewere ọnọdụ ozugbo, kama nwayọ. Usoro dị otú a na-eme ka ihe belata ọnọdụ hypoglycemic dị ukwuu.

Ojiji nke glibenclamide nwere mmetụta dị mma na ịbawanye ụba nke ndị na-anabata insulin na-enweta insulin na akwara akụkụ, nke na-akpali mmetụta ndị ọzọ. Ọzọkwa, ekele maka ihe ndị dị na nkwadebe ahụ, ojiji nke glucose na akwara na imeju na-abawanye, usoro glycogen dị na ha na-apụta (ọpụpụ nke glucose site na imeju na-ebelata). Ọgwụ a nwere hypolipPs na mmetụta antidiuretic, na-enyere aka belata arịa nke thrombogenic nke ọbara, na-egbochi ime arrhythmias.

Mmetụta ọgwụ ahụ pụtara ka elekere abụọ ka nchịkwa gasịrị, rute elu ya mgbe elekere asatọ gachara, ọ rụpụtara ihe ruru awa iri na abụọ.

Glibenclamide na-ewe ngwa ngwa ma zuo ezu site na eriri afọ. Mgbe abatachara, a gbanwere ya ka ọ bụrụ metabolites abụọ na-adịghị arụ ọrụ, otu n'ime ha na-apụ apụ na mmamịrị, na nke abụọ ya na ọnya afọ.

Ofzọ eji Glibenclamide na usoro onunu ogwu

A na -ekwu okwu Glibenclamide mgbe e risịrị nri otu ugboro ma ọ bụ ugboro abụọ n'ụbọchị. Ọ bụ n’usoro ọkpụrụkpụ ọgwụ a ka dọkịta depụtara ya n’otu n’otu, dabere ogo ọrịa ahụ. Bido usoro ọgwụgwọ jiri 2.5 - 5.0 - 10.0 mg kwa ụbọchị. Mgbe emesịrị ọ̀tọ glucose dị n'ọbara, ọ̀ ga-ahazi ihe ndị a na-arụ na ha ka nke 5.0 - 7.5 mg kwa ụbọchị.

Ọ bụrụ na n’ime izu isii kwa ụbọchị ọgwụ kwa 20 mg enyeghị ọgwụ ọgwụ, ọgwụ adịghị arụ ọrụ maka onye ọrịa a. N'okwu a, enwere ike ijikọ Glibenclamide yana analogues ma ọ bụ biguanides ya. Ọ bụrụ na ngwakọta a anaghị enyere aka, ọ dị mkpa ịkọ ọgwụ insulin.

Ọ bụrụ na ntụgharị si na ọgwụ ọzọ na-ebelata ọbara shuga, a na-atụkwa ọgwụ kwa ụbọchị nke 2.5 mg. Ọ bụrụ na ọ dị mkpa, ọ na-ebili kwa ụbọchị 5 site na 2 mg ruo mgbe a ga-akwụ ụgwọ ụgwọ. Mkpụrụ kachasị maka ya bụ 20 mg.

A naghị atụ aro ịhọpụta Glibenclamide n'otu oge na butadione, MAO inhibitors na coumarin. Ekwesịrị ịkpachara anya n'oge nchịkwa nke ọgwụ a yana anabolics, H3-histamine recepor blockers, na chloramphenicol.

Ihe ngbanwe

Dịka ntuziaka ahụ si dị, ekwesighi iwere Glibenclamide na coma na precomatose nke nsụhọ, ketoacidosis, ọrụ akwara na arụ ọrụ ọbara, leukopenia, platelet, yana nwata na oge uto.

A naghị atụ aro iji ọgwụ a maka ụmụ nwanyị n’oge ime na lactation.