Mikardis Plus > Ọgwụgwọ na mgbochi

Nkọwa nke metụtara 24.08.2014

Aha Latin: Micardisplus
Koodu ATX: C09DA07
Arụ Ọrụ: Hydrochlorothiazide + Telmisartan (Hydrochlorothiaz>

Otu mbadamba Micardis Plus nwere 40 ma ọ bụ 80 mg telmisartan na 12.5 mg hydrochlorothiazide.

Ndị e mere: sodium hydroxide, meglumine, povidone, sorbitol, magnesium stearate, lactose monohydrate, iron oxide acha ọbara ọbara microcrystalline cellulose, sodium carboxymethyl stachi,ọka ọka.

Pharmacodynamics na pharmacokinetics

Mlọ ọgwụ

Mikardis Plus bụ ngwakọta telmisartan (ihe mgbochi ngọngọ angiotensin ụdị nke abụọ) na hydrochlorothiazide (diuretic ụdị thiazide). Ngwakọta ndị a jikọtara ọnụ na-eme ka sie ike mmetụta antihypertensivekarịa iji ha otu otu. Theakingụ ọgwụ 1 otu oge kwa ụbọchị na-eduga n'ịbelata mgbali elu nwayọ.

Telmisartan - ihe na - ahọrọ ihe nnabata angiotensinụdị nke abụọ. Nwere mmekọrịta dị elu maka ndị na-anabata ya ụdị angiotensin II AT1. Ọ chịpụrụ mmadụ angiotensin II sitere na onye nnabata. Idochi mmadu aru ogologo oge. Telmisartan anaghị egbochi ndị ọzọ nnabata (gụnyere ATdị AT2ndị nnata) angiotensin. Telmisartanna - ebelata njikọta aldosterone.

N'ime ndị mmadụ na- ọbara mgbali ike 80 mg telmisartan Kwa ụbọchị na - egbochi mmetụta angiotensinII. Mmalite nke usoro a na-apụta awa atọ mgbe ị ofụ ọgwụ ahụ. Omume ahụ dị otu ụbọchị. Na-adịgide adịgide mmetụta antihypertensive idozi otu ọnwa mgbe ejiri ya mgbe niile telmisartan.

Hydrochlorothiazide bụ diuretic ụdị thiazide. Ọ na - emetụta ntụgharị nke electrolytes na tubules nke akụrụ, na - abawanye excretion nke sodium na chlorides. Nke a na-eme ka mbelata mgbasa ọbara, mmeba ụba ọrụ reninmụbaa njikọ aldosterone.

Mgbe emechara hydrochlorothiazide diureis na-ebili mgbe awa abụọ gachara, a na-enweta nsonaazụ kasịnụ mgbe awa anọ gachara were awa 6-12.

Mlọ ọgwụ

Telmisartan.Anọrọ ngwa ngwa si na nri diges. Rationta oke telmisartanna-abata n’ime otu awa. Bioavailability bụ 50%.

Nzaghachi na protein protein - karịa 99.5%. Metabolized site na mmekọrịta ya na acid glucuronic. Nchịkwa telmisartan ọgwụ anaghị arụ ọrụ.

Ọkara ọkara bụ ihe dịka awa iri abụọ. E wepụrụ ya na ahịhịa n'ụdị ya dị mbụ yana yana akụrụ - ihe ruru 2%.

Mlọ ọgwụ telmisartann'ime ndị agadi, ọ dịghị iche na ndị ọrịa dị obere. Achọghị ịhọrọ dose.

Hydrochlorothiazide. Mgbe nchịkwa ọnụ hydrochlorothiazide a na-enweta ntinye uche kachasị mgbe awa 1-2 gachara. Bioavailability ruru 60%.

Nzaghachi na protein plasma - 64%. Ọ bụ metabolized ma dọpụ ya site na akụrụ na-agbanweghi.

Mlọ ọgwụ

Telmisartan

Mgbe ị na-a theụ ọgwụ ahụ, ọ na-amịkọrọ site na eriri afọ n'ime ọbara nwa obere oge. Ọ dị mkpa ịmata ọdịiche dị n'etiti ọgwụ na nri. Ọ bụrụ na ejikọtara ihe omume abụọ a, bara uru ogo ọgwụ a na-efu, arụmọrụ belata pasent iri ise. Centta ahụ ruru ọkwa atọ achọrọ ka awa techara mbadamba mmanya ahụ.

Mgbe oge ụfọdụ gasịrị, ọgwụ ahụ egosiri Site na eriri afọ na-agbanweghi.

A naghị eme mgbanwe ndozi dabere na afọ onye ọrịa dị. N'ime ahụ ụmụ nwoke na ụmụ nwanyị n'ọmụmụ ihe, a na-ahụta ihe dị iche iche nke ihe ahụ, nke a nwere ike ịdabere na ntinye nke ihe ndị dị na ya na ọsọ ọsọ nke nnabata.

N'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa, ọgwụ a ji nwayọ nwayọ karịa karịa ndị ọzọ. Mana enwere ike ịnwe ụdị ọgwụgwọ iche na ọgwụ nwoke na nwanyị.

Enyere Ọgwụ Mikardis na-abụkarị nchọpụta nke ọrịa dịka:

Ọbara ọbara,
Obi n’ọkpụkpụ obi,
Iji belata ọrịa obi na ọrịa n’arịa ndị ọrịa gaferela afọ iri isii.

Ihe ngbanwe

Ọgwụ Mikardis emela maka ọgwụgwọ n'ọnọdụ ndị a:

O buru na achoputara onye oria na anagide isi ya ma obu ihe inyeaka ya.
Ime na inye nwanyi ara,
Ndị ọrịa na-erubeghị afọ iri na asatọ
Ọ bụrụ na achọpụtara egbochi mọzụkọ ma ọ bụ ọrịa ndị ọzọ yiri ya,
Site n'ịrụ ọrụ ọrụ imeju.
Ọ bụrụ na achọpụtara anabataghị fructose,
Na isi aldosteronism.

N'iji nlezianya, ejiri Mikardis mee ihe imebi:

Ọrụ umeji
Biinal akwara akwara Stenosis,
Potassium dị elu
Sodium ụkọ
Ọrịa obi na-adịghị ala ala
Na ọtụtụ nsogbu ndị ọzọ gbasara ahụ.

Ofzọ nke ngwa

Mpempe Mikardis ka a na-ewere ọnụ. Ezigbo usoro ị theụ ọgwụ ahụ bụ otu mbadamba, yana ịta 40 mg otu ugboro kwa ụbọchị. Ọ bụrụ na nke a ezughi, ọnụọgụ ọgwụ nwere ike okpukpu abụọ, mana ọ gaghị aba. Mmetụta site na ọgwụgwọ, enwere ike ọ gaghị enweta ya ozugbo, yabụ ọsọ ọsọ ịbawanye usoro onunu ogwu. Ikwesiri ichere maka oge ọgwụgwọ akọwapụtara, nke bụ izu anọ na asatọ.

Ndị ọrịa na-anwale usoro ịba ọga ala mgbe niile agaghị agafe usoro ọgwụ dọkịta họọrọ n'ọnọdụ ọ bụla.

N'ime ndị ọrịa nwere ọrịa imeju na-adịghị ala ala ma dị nro, usoro ọgwụgwọ kwa ụbọchị anaghị agafe 40 mg kwa ụbọchị.

Maka ndị okenye, ọnụọgụ ọgwụ kwesịrị ịdị ntakịrị ka ọ ghara imerụ ahụ.

Mwepụta wepụtara ya na ihe mejupụtara

A na-emepụta Mikardis Plus n'ụdị mbadamba - biconvex, oval, oyi akwa abụọ:

usoro onunu ogwu 40 / 12.5 mg na 80 / 12.5 mg - otu akwa nke agba pink-beige na agba, nke abuo - agba ocha n’enwe ocha nke nwere agba pink-beige, n’elu uchadi enwere ihe “H4” (40 / 12.5 mg) ma ọ bụ “H8” (80 / 12.5 mg), na akara ụlọ ọrụ (7 PC. na ọnya, na otu kaadiboodu nke 2, 4 ma ọ bụ 8 blisters),
usoro onunu ogwu 80/25 mg - otu akwa di ocha, nke nwere oghe edo edo, nke abuo bu odo odo, n’elu ucha ocha enwere “H9” na akara ngosi nke ulo oru (7 onye obula n’ime ngwugwu ocha, na ngwugwu nke 1, 2 ma obu 4 blisters).

Otu mbadamba 1 nwere:

bekee na-arụ ọrụ: telmisartan - 40/80 mg + hydrochlorothiazide - 12.5 mg ma ọ bụ telmisartan - 80 mg + hydrochlorothiazide - 25 mg,
ihe ndị ọzọ: povidone, sodium hydroxide, meglumine, magnesium stearate, sorbitol, microcrystalline cellulose, lactose monohydrate, stachi ọka, sodium carboxymethyl stachi, iron oxide red (40 / 12.5 na 80 / 12.5), iron oxide odo ( 80/25).

Telmisartan

Telmisartan bụ onye na - ebuso ya agha (mgbochi) nke ndị na - anabata A-II (AT₁ subtype) na-egosi mmetụta antihypertensive na iji ọnụ. Ọ nwere mmekọ dị elu maka AT₁ ụdị nke nnata nke A-II, nke sitere na nzaghachi nke ikpeazu. Ọ naghị egosipụta mmetụta agonistic ọ bụla na onye na-anabata ihe, site na nke A-II chụpụrụ. Ngwaọrụ nọ n'ọrụ na-ahọta na AT₁ ụdị nke ndị na-anabata A-II, ebe enweghị ya mmekọrita maka AT₂ ụdị ụdị, yana ndị ọzọ na-anabata angiotensin. Amụghị uru ọrụ nnabata ndị a na nsonaazụ nke ike ha ga-agbasa n'ihi mmetụta nke A-II, nke ogo ya na-abawanye na telmisartan. Akụkụ dị ike na-eme ka mbelata aldosterone n'ọbara, anaghị egbochi ụzọ ion ma ọ dịghị egbochi ọkwa renin na plasma ọbara. Telmisartan anaghị egbochi enzyme angiotensin-ACNAN (ntụgharị) - kininase nke abụọ, nke na-emebi bradykinin, yabụ, ịbawanye n'ihe ize ndụ nke mmeghachi omume achọghị n'ihi bradykinin.

Na ọnụnọ nke ọbara mgbali elu, ojiji nke telmisartan na dose nke 80 mg kpamkpam na-egbochi mmetụta nke A-II. Ọrụ antihypertensive nke ihe ahụ mgbe nchịkwa ọnụ mbụ ya pụtara ìhè n'ime awa 3. Mmetụta nke ọgwụ ahụ na-adịgide ruo awa 24 ma na-adịgide ruo 48 awa. Ọ na-adịkarị mfe ịnweta nsonaazụ hypotensive ụbọchị 28 mgbe mmalite nke usoro ahụ, ọ bụrụhaala na a na-ewere Mikardis Plus.

N'ime ndị ọrịa nwere ọbara mgbali elu, telmisartan na-ebelata ma mgbagha ọbara systolic na diastolic na-enweghị na-agbanwe mgbanwe mkpụrụ obi (HR). Ọ bụrụ na ọ dị mkpa ịkagbu ngwa ahụ, ọbara mgbali jiri nwayọ laghachi n'ụzọ mbụ ya na-enweghị ihe ọghọm nke ibute ọrịa.

Na nyocha nke telmisartan, a na-enyocha ọnọdụ nke ọnwụ obi, ọrịa strok na-adịghị egbu egbu, ọrịa infarction na-adịghị egbu egbu, ma ọ bụ ụlọ ọgwụ n'ihi ọrịa obi na-adịghị ala ala (CHF). Ndị ọrịa toro afọ 55 n'ọrịa isi ọwụwa, ọrịa obi akwara akwara, ọrịa akwara ma ọ bụ ọrịa mellitus nwere mmerụ ahụ akụkụ akwara mkpụrụedemede (ogwe aka ekpe ventricular, retinopathy, akụkọ ihe mere eme nke macro-ma ọ bụ microalbuminuria) gosipụtara mbelata nke ọrịa obi na ọnwụ.

Hydrochlorothiazide

Hydrochlorothiazide bụ thiazide diuretic. Akụrụngwa, dịka ndị nnọchite ndị ọzọ nọ na klas a nke na - egbochi ọgwụ, na - emetụta usoro nke reabsorption nke electrolytes na teliles renal, na - amụba mkpịsị nke sodium na chlorides (ihe ruru, nha anya) Nsonaazụ nke ihe diuretic nke ọgwụ bụ mbelata olu nke inye ọbara (BCC), mmụba na ọkwa plasma nke renin n'ime ọbara, mmụba nke mmepụta aldosterone na mmụba na-esote ọdịnaya nke potassium na bicarbonates na mmamịrị, nke na-eduga na mbelata mkpokọta nke potassium na plasma ọbara.

Site na iji ihe eji eme ihe na telmisartan, ikekwe n'ihi mgbochi nke sistemụ renin-angiotensin-aldosterone (RAAS), belata potassium na-ejikọ ya na diuretic a. Mgbe nchịkwa ọnụ nke hydrochlorothiazide, a na-achọpụta ụba diuresis mgbe elekere 2 gachara, na nsonaazụ kachasị bụ ihe dị ka awa anọ. A na-ahụta ọrụ akwara Mikardis Plus ihe dị ka awa 6-12.

Iji hydrochlorothiazide ruo ogologo oge na-ebelata ohere ihe ọghọm nke ọnya obi na ọnwụ site na ha.

Mmetụta antihypertensive nke Mikardis Plus, dị ka a na-achị, na-eru izu asatọ 4-8 mgbe mmalite ọgwụgwọ.

Dodoụbiga ya ókè

Ọnọdụ nke ịdoụbiga mbadamba ókè nke Mikardis Plus adịghị edozi.

Mgbaàmà nke oke nnyefere nke ọgwụ ndị na - arụ ọrụ nwere ike ịbụ:

telmisartan: bradycardia, tachycardia, mbelata ọbara mgbali elu,
hydrochlorothiazide: hypokalemia, hypochloremia na nsogbu ndị ọzọ nke mmiri-electrolyte ọbara, mbelata na BCC, na-eme ka mmerụ ahụ na / ma ọ bụ na-ebute nsogbu nke usoro obi (arrhythmias n'ihi otu oge nke iji glycosides cardiac ma ọ bụ ụfọdụ ọgwụ antiarrhythmic ọzọ).

Site na mmepe nke mmeghachi omume ndị a, a na-enye usoro ọgwụgwọ Symptomatic, telmisartan anaghị ewepụ ọbara site na iji hemodialysis. Hydrochlorothiazide sitere na ahụ site na hemodialysis, agbanyeghị, ekwenyebeghị ogo iwepụ ya. Ọ dị mkpa ilele ọkwa nke creatinine na itule electrolyte n'ọbara ọbara.

Ntụziaka pụrụ iche

N'ọnọdụ ụfọdụ, n'ihi mmachi nke ọrụ RAAS n'oge ọgwụgwọ na ọgwụ, tumadi na iji ọgwụ a na-ejikọ ọnụ na ọgwụ ndị na-emetụta usoro a, ọrụ ezumike na-emebi emebi (gụnyere mmepe nke nnukwu gbasara akụrụ ọdịda). N'ihi nke a, aga-ejikwa ọgwụgwọ nwere njikọ mgbochi abụọ nke RAAS (dịka ọmụmaatụ, yana nchikota Mikardis Plus na ACE inhibitors ma ọ bụ aliskiren), ejiri nlezianya nyochaa usoro ọrụ akụrụ (gụnyere nyochaa ọkwa nke potassium na creatinine n'ọbara ọbara).

N'ime ndị ọrịa nwere ọrịa obi (CHD) na ọrịa shuga mellitus mgbe ha na-anara ndị na-anabata A-II, ohere dị ukwuu na-egbu egbu myocardial infarction na ọnwụ obi mberede. Ebe ọ bụ na ọnụnọ nke ọrịa mellitus nke ọrịa shuga, enwere ike ịchọpụta ọrịa obi na-arịa ọrịa obi n'ihi usoro asymptomatic, maka nchọpụta ya na ọgwụgwọ tupu ọgwụgwọ, Mikardis Plus chọrọ nyocha kwesịrị ekwesị (gụnyere nnwale na mmega ahụ).

Hydrochlorothiazide bụ ihe dị n'ụdị sulfonamide ma nwee ike ibute mmepe mmeghachi omume idiosyncratic, gosipụtara n'ụdị nnuku nkuku -emechi glaucoma na nnukwu oge myopia. Ihe mgbaàmà nke nsogbu ndị a gụnyere mgbu anya ma ọ bụ mbelata nke nhụsianya anya, nke n'ihe ka ọtụtụ na - apụta site na awa ole na ole ruo ọtụtụ izu mgbe ịmalite Mikardis Plus. Enweghị ọgwụgwọ, glaucoma nwere nnukwu ọrịa mepụtara nwere ike ibute ọhụhụ. Maka ọgwụgwọ nke mmeghachi omume a, nke mbụ, achọrọ ya ozugbo ịkwụsị hydrochlorothiazide. Ọ bụrụ na nrụgide intraocular na-anọgide na-enweghị nchịkwa, ọgwụgwọ ngwa ngwa ma ọ bụ ọgwụgwọ ịwa ahụ nwere ike ịdị mkpa. Ihe ndị dị ize ndụ maka glaucoma nnukwu ọrịa nwere ike ịbụ akụkọ ihe mere eme nke penisilini ma ọ bụ sulfonamides.

Hydrochlorothiazide, dị ka ọgwụ thiazide ndị ọzọ, nwere ike ibute ọgba aghara na mmiri-electrolyte na steeti acid-base (hyponatremia, hypokalemia, na hypochloremic alkalosis). Ihe ịrịba ama nke nsogbu a nwere ike ịgụnye akpịrị ịkpọ nkụ, akpọnwụ akpọnwụ, adịghị ike n'ozuzu, nchekasị, ụra ụra, adịghị ike akwara, myalgia ma ọ bụ ntigbu akwara nke nwa ehi (crumpi), mbelata ọbara mgbali elu, ọgbụgbọ, vomiting, tachycardia, oliguria.

Egwu nke hypokalemia na-abawanye tumadi na ndị ọrịa nwere ọrịa imeju, na-emegide nrịba diuresis, na nri nnu na-enweghị n ’ọnọdụ nke njikọta Mikardis Plus na gluco-na mineralocorticosteroids ma ọ bụ corticotropin.

N'agbanyeghi eziokwu na enweghi hyperkalemia ogwu di egwu banyere ọgwụgwọ Mikardis Plus, ekwesiri iburu n'uche na ihe ndi nwere ike ibute ya bu oria mellitus, obi na / ma obu akuko.

Ihe omuma nke gosiputara ikike nke Mikardis Plus iji belata ma obu gbochie mmepe nke hyponatremia nke riri diuretali adighi. Achọpụtara hypochloremia, dị ka iwu, enweghị ihe ọ bụ na ọ chọghị ọgwụgwọ.

Ihe akwara nke Thiazide na-eme ka ohere nke klọọkụ belata belata site na akụrụ na mpụta oge dị ntakịrị na mmụba dị ukwuu na ọkwa calcium. Mmepe nke hypercalcemia siri ike nwere ike ịbụ ihe mgbaàmà nke hyperparathyroidism latent. Ọ bụrụ na achọrọ nyocha banyere ọrụ parathyroid, ekwesịrị ịkwụsị thiazide diuretics.

Omume Mikardis Plus abaghị uru ọ bụla na ndị ọrịa agbụrụ Negroid.

Nsonaazụ

Site na sistem iku ume: mkpụmkpụ ume, nsogbu iku ume iku ume.
Site na sistemụ mgbasa: tachycardia, arrhythmias, bradycardia, mgbada nrụgide siri ike.
Site na sistem ụjọ: nkụda mmụọ, paresthesiaanya ntughari ehighi uranchegbu ịda mbamgbakasị ahụ, isi ọwụwa.
Site na nri digestive: flatu, afọ ọsịsa,n’ọnụ, afọ na-egbu mgbu, afọ ntachigastritis, hypercholesterolemia, hyperglycemia, pancreatitis,jaundice dyspepsia.
N’akuku anụ ahụ: ọsụsọ.
Site na usoro mọzụlụ: uru ahụ, arthralgia, myalgia, ọrịa ogbu na nkwonkwoobi mgbu.
Site na sistemụ hemopoietic: leukopenia, eosinophilia, anaemia, neutropenia, thrombocytopenia, thrombocytopenia.
Site na mpaghara mkpụrụ ndụ: ọdịda akwara, nephritis, glucosuria.
Site n'anya: enweghi ike ịhụ ụzọ, glaucoma, xanthopsia, oke myopia.
Ọrịa: sepsisakụkụ okuku ume na ọrịa (pharyngitis, bronchitis, sinusitis), mbufụt nke gland.
Ọrịa metabolism: mmụba creatinine, enzymes imeju, creatine phosphokinase, uric acid n’ime ọbara hypertriglyceridemia, hyperkalemia, hypokalemia, hypoglycemia, hyponatremia, iju haemoglobin.
Mmeghachi omume nfụkasị ahụ: akpụkpọ ahụ, angioedemaihe odide erythema, mmeghachi omume anaphylactic, eczema, vasculitis system, necrotic vasculitis.

Mmekorita

Mgbe ị na-ekekọrịta telmisartan ya na:

ọgwụ mgbochi ndị ọzọ na - egbochi ike - mmụba nke ike ga - ekwe omume mmetụta antihypertensive,
ọgwụ lithium - mmụba nwa oge na ọdịnaya ga - ekwe omume lithium n’ime ọbara
ọgwụ mgbochi anaghị agwọ ọrịa - enwere ike ịpụta nnukwu akwara ọdịda n'ime ndị ọrịa nwere ọ̀tụ̀tụ̀ ọbara ji erugharị,
digoxin - ịba ụba na itinye uche ga - ekwe omume digoxin n'ọbara site na 20%.

N'iji oge eme ihe hydrochlorothiazide ya na:

barbiturates, ethanol ma obu opioid ndị na - egbu mgbu - mmepe ga - ekwe omume orthostatic hypotension,
Metformin - mmepe enwere ike lactic acidosis,
ndị ọrịa hypoglycemicna insulin - oghaghari dose ọgwụ hypoglycemic,
cholestyramine na colestipol- igbochi nnabata ga - ekwe omume hydrochlorothiazide,
anaghị eme ka akwara dị jụụ - enwere ike ime ka mmetụta ha ka mma,
obi glycosides - mmepe enwere ike hypokalemiama obu hypomagnesemia,
ndị na - egbochi anti gout - enwere ike iwelie afọ ojuju uric acid n’ime ọbara.
nhazi nke calcium- enwere ike ịbawanye na ịta kalshial n'ime ọbara n'ihi egbochi ya iwere site na akụrụ.
amantadineOria nwere nsogbu nke mmetụta na - achọghị amantadine,
m-anticholinergic na-egbochi(atropine, biperiden) - enwere ike imebi umeji eriri afọ, mụbaa bioavailability thiazide diuretics,
ọgwụ mgbochi anaghị agwọ ọrịa - ike kwere omume diuretic na mmetụta antihypertensive.

1. Ntuziaka maka mbanye

N'ime edemede ị nwere ike ịchọta data na ihe ngosi, usoro nchịkwa ma ọ bụ usoro ọgwụgwọ achọrọ (ọ bụrụ na achọrọ ya, otu esi agbakọ ya), ihe mejupụtara, ụdị a ga-esi mepụta ọgwụ a, jikọta ọgwụ a na ọgwụ ndị ọzọ, ọnọdụ nke ọ na-anabataghị. na-a medicineụ ọgwụ, ọnụego ọnụahịa, analogues, yana nyocha nke ndị ọrịa na-a thisụ ọgwụ a.

Na mgbakwunye, ebe a ị nwekwara ike ịchọta data maka ihe ị ga-eme ma ọ bụrụ na ị na - enwebiga ihe oke ókè. Ekwesiri iji nlezianya nyochaa ozi a ka ị ghara ihu nsonaazụ na-adịghị mma.

Nsonaazụ

N'oge ọgwụgwọ na Mikardis, ndị dị otú ahụ ngbako mmetụta:

Sistemụ akwara Central - nkụda mmụọ, vertigo, nchekasị, ehighị ụra nke ọma, nkụda mmụọ,
Ọrịa - cystitis, ọrịa akụkụ okuku ume na elu, sepsis,
Sistem: Ọbara (thrombocytopenia), anaemia, mbelata nke Hemoglobin dị elu,
Ọhụụ - nghọta dị omimi nke ihe osise ma ọ bụ nsogbu ndị ọzọ nwere ike ịpụta,
Usoro nri - akpọnwụ akpịrị, afọ mgbu, ọgbụgbọ, ọgbụgbọ,
Akwara na ọkpụkpụ - azụ mgbu, myalgia, mgbu dị nkọ na akwara na nkwonkwo, ọnọdụ ihe mgbu,
Mmeghachi omume ndị ọzọ nwekwara ike ime, dịka ọmụmaatụ, adịghị ike nke izugbe, ụra ụra, ma ọ bụ ihe mgbu n'akụkụ ụfọdụ nke ahụ.

Ndakọrịta na ọgwụ ndị ọzọ

Ihe na - arụ ọrụ nke ọgwụ Mikardis nwere ike ịbawanye nsonaazụ nke ọgwụ ndị ọzọ, nke n'aka nke ya, belata ọbara mgbali elu.

Ọzọkwa ịta ahụ digoxin n'ime ahụ na-abawanye, n'ihi nke ọ dị mkpa iji nyochaa nyocha niile.

site na iji ọgwụ Mikardis ruo ogologo oge, ọnụego mgbochi nwere ike ịgbanwe vasoconstrictor ọgwụ ọjọọ, ma na-agbanwezi ihe gbasara mmeghachi omume akwara.

Ọnọdụ nchekwa

Ekwesịrị ịchekwa ọgwụ ahụ ka ụmụaka ghara iru ya. Nwere ike ịnwe ya n'ime ụlọ ebe okpomọkụ anaghị agafe ogo iri nke okpomoku. Mbadamba, ma ọ bụrụ na agbajighi, a na-echekwa nkwakọ ngwaahịa nke ha ihe dị ka afọ atọ, mgbe emesịrị iji ya akwadoro.

Ọbụna na ogbo nke ịhọrọ ọgwụ ahụ, a gwara m na Mikardis nwere mmetụta ọgwụgwọ na-arụ ọrụ. Ekpebiri m ịnwale ya n'onwe m, ọkachasị ebe ihe akaebe ahụ dị oke mkpa. Were ọgwụ, dọkịta nyere ọtụtụ izu iji belata mmetụta ha. Ma ọgwụgwọ ahụ amalitela. N'ezie ọnụ ahịa ahụ dị elu maka m, mana m kpebiri na analọg nwere ike ọ gaghị enwe otu mmetụta ahụ Mikardis n'onwe ya ma theụọ ihe mbụ. N’ime otu izu, ahụ bịara dị m mma. Ekele diri ndi dibia na Mikardis.

Mgbe nne m na-arịa ọrịa, anyị nwara ọtụtụ ọgwụ, na-anwa ime ka ọnọdụ ya ka njọ, mana ha enyereghị aka ogologo oge. Mgbe anyị nyochachara dọkịta na ụlọ ọgwụ, anyị kpebiri ịnwale atụtụ ọnụ dị oke ọnụ nke Mikardis. N'ụzọ dị ịtụnanya, ọgwụ malitere ime ihe ọ bụla ozugbo. Enwere m mmasị na eziokwu ahụ bụ na a nabatara ọnụahịa ahụ yana ihe mejupụtara ihe ndị dị ike mejupụtara kpamkpam. Ekele diri onye obula mere anyi otu udiri ogwu a.

Dọkịta nyere m iwu ị Mikụ ọgwụ Mikardis gbakwunyere. Mgbe m gụchara nyocha dị iche iche banyere nsonaazụ ya na anụ ahụ, m kpebiri ịnwale analogues. Ha dị m ka ha anaghị emerụ ahụ m ahụ. Mana mgbe oge ụfọdụ gasịrị, ọgwụgwọ ọgwụgwọ pere mpe ma ekpebiekwa iji ọgwụ a kpọrọ micardis. Ọ ka mma.

Ngwakọta na ọgwụ ọgwụ ọgwụ

Ihe kachasị dị mkpa nke ọgwụ bụ telmisartan. Otu mbadamba ihe mejupụtara a nwere milligram 80, 40, na 20. Ndi dibia ogwu n’eme ka nnabata nke ihe mejuputara ya bu: meglumine, sodium hydroxide, polyvidone, sorbitol na steeti magnesium. Ogwu a, na mgbakwunye telmisartan, nwere ihe ozo di milili iri 12.5 nke hydrochlorothiazide - ihe bu ihe diure. Nchikota nke diuretics na antiotensin antagonist na-eme ka o kwe omume inweta ihe ndi ozo di egwu. Mmetụta ahụ na-eme ka ọ dị ihe dị ka awa abụọ mgbe ọ .ụchara ọgwụ ahụ.

Mikardis Plus bụ onye na - emegide ihe ndị na - anabata ya maka angiotensin homonụ. Homonụ a na - eme ka ụda olu nke akwara ozi dịkwuo ala, nke na - eduga n'ịbelata oghere ọbara. Telmisartan bụ otu ihe mejupụtara ya na kemịkalụ nke ndị na - anabata ndị na - anabata angiotensin.

Mgbe ọ batasịrị ahụ, ọgwụ a na-emekọrịta mmekọrịta n'etiti ndị na-anabata ya, nke na-eduga na ngbanwe nke angiotensin, si otú a wepụ isi ihe kpatara mmụba ọbara mgbali. Telmisartan na-eduga ná mbelata systolic na, na mgbakwunye, nrụgide diastolic, mana ihe a anaghị agbanwe ike ya n'ụzọ ọ bụla yana ọnụọgụ nke akwara obi. Gịnị ka akwụkwọ akụkọ Mikardis Plus na-agwa anyị?

First theụ ọgwụ mbụ na - eduga n'ọgwụ nwayọ nwayọ: ọ na - agbada nwayọ nwayọ nwayọ ugboro ole na ole. Mgbe enwere mbadamba mbadamba mbadamba mkpụrụ ọgwụ ga-ahụ ihe dị ka otu ụbọchị. N'ihi ya, iji mee ka nrụgide ahụ dị nkịtị ma na-achịkwa ya, a chọrọ ị drinkụ ọgwụ ahụ naanị otu ugboro n'ụbọchị. Ihe kachasị, ma n'otu oge ahụ, nrụgide na-adịgide adịgide na-apụta mgbe ọnwa gasịrị site na ịmalite ọgwụgwọ na ọgwụ a ọkọnọ. N'ọnọdụ ebe a kagburu ọgwụ ahụ na mberede, nsonaazụ mwepu anaghị eme, ya bụ, nrụgide ahụ na-alaghachi na njirimara mbụ ọ bụghị nke ọma, mana, dịka iwu, nke a na-eme n'ime izu ole na ole.

Akụkụ niile dị na Mikardis Plus, mgbe a na -ewere ya ọnụ site na eriri afọ, ana-abanyekwa ngwa ngwa, bioavailability nke ọgwụ ahụ ruru ihe dị ka pasent iri ise. A na-ekpebi mgbakwunye akụkụ ahụ na-arụ ọrụ na plasma mgbe awa atọ gachara. Usoro metabolization na-aputa ihe site na mmeghachi omume nke telmisartan na glucuronic acid. Metabolites ndị a na-arụpụta anaghị arụ ọrụ. Ọkara ndụ nke ọgwụ ahụ karịrị awa iri abụọ. Ọkpụkpọ ọgwụ eji eme nri na-apụ apụ n'anya. Banyere mmamịrị, ihe na-erughị pasent abụọ nke ọgwụ na-apụta.

Mbadamba Mikardis Plus dị na atọ atọ: 80, 40 na 20 milligram nke telmisartan. Na agbanyeghị oke ngwa eji eme ihe, mbadamba nkume niile nwere ọdịdị ya na agba ọcha. Edere ihe osise nke ụlọ ọrụ ahụ n'otu akụkụ nke mbadamba. Mbadamba 40 milligram nwekwara 51N embossed. Ndị ahụ bụ milligram iri asatọ na ise ka-kanyere ya na uru 52N. N'ime otu ngwugwu enwere plisters abụọ ruo asatọ, nke ọ bụla nwere mbadamba asaa.

Kedu mgbe ị ga-eji ọgwụ ahụ?

Dabere na ntuziaka ahụ, e mepụtara Mikardis Plus (80 + 12, 5 mg) maka ọgwụgwọ ọbara mgbali elu. Doctorsfọdụ ndị dọkịta depụtara ọgwụ a maka ndị ọrịa gafere afọ iri ise na ise, ndị a chọpụtara na ha nwere ohere dị elu nke ọrịa obi ọfụma na-emetụta ọbara mgbali elu. Ọ dị mma ịmara na edere ọgwụ ahụ na ikpe ahụ mgbe ọ na-enweghị ike ịnweta mbenata nrụgide achọrọ ka ị na-ewere ụdị ọgwụ a.

A naghị atụ aro ịkọ ọgwụ a maka onwe gị wee họrọ usoro ọgwụgwọ ya, ebe ọ bụ naanị dọkịta nwere ike ịchọpụta ọgwụ mgbochi ọ bụla site na nyochaa nyocha nke onye ọrịa ahụ n'ụzọ ziri ezi. Ohere nke nsonaazụ ndị ọzọ dabere na etu esi ahọrọ usoro ọgwụgwọ ọfụma.

Kedu mgbe a na-ewere ọgwụ ka contraindicated?

Ọgwụ ekwesịghị iji ọgwụ a mee ihe ndị a:

N'ọnọdụ ebe enwere hypers na isi ma ọ bụ ihe ndị ọzọ nke ọgwụ a.
Ọgwụ a adabaghị maka ụmụ nwanyị nọ n'ọnọdụ, mana, na mgbakwunye, ọ bụrụ na a na-enye nwa ara.
Ọgwụ a adịghị mma ọbụlagodi mgbe ndị ọrịa nwere ọrịa biliary traktị na-emetụta ikike ha n'ozuzu ha.
Ọnụnọ nke nnukwu nsogbu n’ọrụ akụrụ na akụrụ.
N'ọnọdụ ebe enwere ọnwụ ekweghị fructose.

Ekwesịrị ịhọrọ analogs na ọgwụgwọ ọbara mgbali elu na ụmụaka ma ọ bụ ndị na-eto eto. Nke a bụ isi n'ihi eziokwu ahụ bụ na etinyere telmisartan na otu anụ ahụ emebeghi nke ọma. Ntụziaka maka iji ya na Mikardis Plus na-egosi na, na mgbakwunye na contraindication niile a dị n'elu, enweghị ike inye ya ndị ọrịa na-arịa hypercalcemia refractory, na nke ọzọ, ọ bụ adịghị mma maka hypokalemia, erughi n'ihi ntinye nke galactose na lactose.

A na-enyekwa ọgwụ mgbochi contraindications nye Mikardis Plus ọgwụ (80 mg). Dịka ọmụmaatụ, ndị dọkịta kwesịrị ịkpachara anya ma depụta usoro ọgwụgwọ dị ala n'ihe banyere ọnọdụ ndị ọrịa nwere oke ọbara, enwere ọrịa ndị a:

Mmepe nke hyponatremia ma ọ bụ hyperkalemia.
Ọnụnọ nke ischemia cardiac n'ime ndị ọrịa.
Mmepe nke ọrịa obi dị iche iche, dịka ọmụmaatụ, n'ụdị oke ume ala, valve stenosis ma ọ bụ cardiomyopathy.
Ọdịdị nke stenosis nke akwara abụọ nke akụrụ. N'ọnọdụ ebe onye ọrịa nwere naanị otu akụrụ, a ga-elebara anya pụrụ iche n'oge nchịkwa ọgwụ mgbe enwere stenosis nke naanị akwara na-arụ ọrụ nke inye ọbara.
Mmepe nke akpịrị ịkpọ nkụ, nke ọrịa na-esonye na vomiting ma ọ bụ afọ ọsịsa na-akpata.
Usoro ọgwụgwọ diuretic gara aga.
Mgbake nke ndi oria mgbe amuchara akuru.

Na mgbakwunye na ọrịa ndị dị n'elu, na nhọpụta Mikardis Plus, onye ahụ kwesịrị ịkpachara anya karịsịa ma ọ bụrụ na ndị ọrịa nwere ọrịa shuga na gout.

Enwere ike ịlele nsonaazụ n'oge ọchịchị

Nyocha banyere "Mikardis Plus" anaghị egosipụtakarị ya na ọkwa dị mma. Patientsfọdụ ndị ọrịa na-akọ banyere ngbanwe nke mgbanwe dị iche iche na-adịghị mma na ọdịmma ha. Ekwesiri ime ka ọ pụta ìhè ozugbo na mmepe nke mmetụta ndị na-adịghị mma na-adabere kpọmkwem na usoro ị theụ ọgwụ ahụ, yana, na mgbakwunye, na afọ ndị ọrịa na ọnụnọ nke ọnya ọnya. Yabụ, enwere ike ịlele mgbanwe ndị a mgbe ị na-a thisụ ọgwụ a:

Ọdịdị nke oge iwe, isi ọwụwa, ike ọgwụgwụ na nchekasị tinyere ọnọdụ dara mbà n'obi, ehighị ụra nke ukwuu, na n'ọnọdụ ka ọ dịkarịsịrị, a naghị agụpụ ihe ịmịcha iwe.
Nnukwu mmụba na nkwụsi ike site na sistem iku ume rue ọrịa nje, nke n'aka nke ya bụrụ isi ihe na-akpata pharyngitis, sinusitis, bronchitis, paroxysmal ụkwara na ihe ndị ọzọ.
Ọdịdị nke dyspeptik n'ụdị ọgbụgbọ, colic, na mgbakwunye, afọ ọsịsa. N'ime ụfọdụ ndị ọrịa, nnwale nwekwara ike igosi mmụba nke enzyme hepatic.
Ọdịdị hypotension - mgbu n'ime mpaghara obi. Ọzọkwa, mmepe nke tachycardia ma ọ bụ, na nke ọzọ, bradycardia anaghị agụpụ.
Ihe omume mgbu na akwara. Ọdịdị nke ihe mgbu na mpaghara lumbar.
Mmepe nke ọnya na-efe efe nke ọnya mkpụrụ ndụ yana njigide mmiri na ahụ.
Ihe omume nke mmeghachi omume nfụkasị ahụ n'ụdị ụdị rashes, urticaria, yana angioedema, itching ma ọ bụ erythema.
Dịka akụkụ nke nyocha ụlọ nyocha, enwere ike ịchọpụta hyperkalemia nke nwere akara anaemia.

Na usoro nke usoro ọmụmụ gbasara ọgwụ "Mikardis Plus", etinyere mmetụta fetotoxic nke ọgwụ. Nyere nke a, ekwesighi ị thisụ ọgwụ a n'oge afọ ime. N'ọnọdụ nke akwadoro ime, mgbe ahụ nwanyị a, dị ka nkwanye dọkịta ahụ si dị, kwesịrị ịgbanwe ka ọgwụ mgbochi ọgwụ na-adịghị ala ala. N'ọnọdụ ịtụrụ ime, a na-akwụsị iji ọgwụ a ozugbo.

Atụmatụ eji

Ọgwụ a kwesịrị ịkọwa ọgwụ "Mikardis Plus" nke dọkịta naanị. Enwere ike iji ya mee ihe naanị ma ọ bụ ya na ọgwụ ọgwụ ndị ọzọ, nsonaazụ nke ebumnuche iji melite arụ ọrụ nke usoro obi. Onye na-emepụta ọgwụ na-atụ aro ịnweta Mikardis Plus kwa ụbọchị ka ọ bụrụ naanị ya na mbadamba ihe ọ withụ aụ nke 40 milligrams nke ihe na-arụ ọrụ.Ma n'otu oge ahụ, ọ dị mkpa ịtụle na na ndị ọrịa na-arịa ụdị ọbara ọgbụgba dị nro, mmetụta hypotensive na-adịgide adịgide nwere ike ịmalite mgbe ụfọdụ mgbe ị na-a aụ ọgwụ ịka-milligram.

A na-eme nhọrọ nke ọgwụgwọ ọgwụgwọ maka izu anọ. Ọ dị ọtụtụ oge ka ọgwụ a iji gosipụta ọgwụgwọ ọgwụgwọ zuru oke. Na mmemme na arụpụtaghị ihe ndị ha chọrọ n'oge a, a na-adụ onye ọrịa ọdụ ka ọ were Mikardis Plus na usoro ọgwụ nke 80 milligrams. Na ọnụnọ nke ụdị ọbara mgbali siri ike karị, a na-anabata nchịkwa nke ọgwụ na ọnụọgụ 160 milligrams nke telmisartan, ya bụ, ya mere, achọrọ mbadamba nkume abụọ nke 80 milligrams. Okwesiri iburu n’uche na n’ihi ihe mmerụ ahụ bụ akụkụ nke Mikardis Plus (80 + 12, 5 mg), nrụgide n’ime ndị ọrịa na-ebelata ngwa ngwa ma dị mma karịa mgbe ị na-ewere ụdị ọgwụ a.

N'ihi ya, dọkịta na-ahọpụta usoro ọgwụ ejikọtara na-adabere n'ịdị ogo nke ọbara mgbali elu. Nyocha banyere "Mikardis Plus" na-akwadokarị mmetụta akpọrọ hypotensive. Ọgwụ a na-ewepụtara bụ oge ọ bụla n'ụbọchị. N'okwu a, iji nri anaghị emetụta digestibility nke ihe ọgwụ ahụ. Dọkịta kpebisiri ike ịgụta ọnụ oge niile, dabere n'ọnọdụ onye ọrịa ahụ, dọkịta ahụ nwere ike ịkwado ịgbanye na usoro mmezi nke 20 milligrams.

Ọrịa ekwesịghị inwe ndị ọrịa nwere akụrụ gbasara akụrụ. N'ọnọdụ na enwere mgbanwe mgbanwe n'ọbara na akwara ọrụ na anamnesis, ọ bụ naanị usoro “40” ka achọrọ. Okwesiri iburu n’obi na mmụba ọ bụla na-eduga ná mbibi nke ọrụ ahụ. Banyere ndị ọrịa agadi, ha anaghị achọ mmezi dose.

Nsonaazụ nke akụrụngwa dị ike nke ọgwụ na ike nke ndị ọrịa ịchịkwa usoro

Ntụziaka agbakwunyere maka iji ọgwụ ahụ "Mikardis Plus" (40 na 80 milligrams) na-akọ na ọ nweghị nnwale ọ bụla emerela banyere mmetụta ọgwụ a na-etinye na ntinye uche, yana ọsọ nke mmeghachi omume. Mana, agbanyeghị, ka ị na-a drugsụ ọgwụ ọgwụ nwere mmetụta dị omimi nke ekpughe, mmadụ kwesịrị iburu n’uche mgbe niile na nhazi ọgwụ nke otu a nwere ike bute iro ụra na oge iwe. N'ọnọdụ ebe ndị ọrụ metụtara ọrụ na-arụ ọrụ nwere ụdị ihe mgbaàmà a, mgbe ahụ, ekwesịrị kenye ha analogues nke Mikardis Plus (80 ma ọ bụ 40 mg).

Njirimara nke ịchekwa ọgwụ na ọnụ ahịa ya

Ekwesịrị ịchekwa ọgwụ a ebe ewezuga ohere ụmụaka. Ọnọdụ okpomọkụ dị n'ime ụlọ nchekwa ahụ ekwesịghị gafere ogo iri atọ. Dịka iwu, enwere ike idobe mbadamba ọgwụ nwere ọgwụ nke 40 na 80 na-enweghị ihe na-emebi emebi ọnya ahụ ihe karịrị afọ anọ site na mgbe amịpụtara ha. Mbadamba 20 milligram nwere ndụ nchekwa dị mkpụmkpụ karịa afọ atọ. Ọnụahịa ọgwụ "Mikardis Plus" na ụlọ ahịa ọgwụ na-adabere kpọmkwem na usoro nke ihe ndị na-arụ ọrụ n'ime ọgwụ ahụ:

Nwere ike ịzụta ọgwụ maka milligram 40, na mbadamba iri na anọ, maka ihe dị ka narị ruble ise.
Mikardis Plus 80 milligrams na mbadamba iri abụọ na asatọ na ụlọ ahịa ọgwụ na-efu nkezi narị iteghete na iri ise.
Ọnụ ego maka idozi mbadamba nkume iri abụọ na asatọ na-amalite site na narị ruble asatọ na iri ise.

Eziokwu, ozi a adịghị na ntuziaka maka iji ya na Mikardis Plus.

Analogues nke ọgwụ

Nyocha banyere ọgwụ a na-abụkarị nke ọma, ebe ọ bụ na ndị jiri ọgwụ a na-achọpụta ihe na-adịghị ahụkebe nke mmetụta ndị ọzọ na-akọ na ọgwụ a dị mma, na, nke kachasị, na-ebelata nrụgide ngwa ngwa. N’eziokwu, ọtụtụ ndị na-azụta ngwa ọrụ a ka ọ kwụsịrị ịdị ọnụ ala. Ekwesịrị ikwu ozugbo na dọkịta ahụ kwesịrị ịhọrọ analogues dị ọnụ ala nke ọgwụ Mikardis Plus. Yabụ, ọgwụ ndị na-esote ọgwụ ndị a ma ama bụ ndị nwere otu ụdị mmetụta na nsonaazụ ahụ: Telmisartan, Teveten, Teseo, Hipotel na Pritor.

Ọnụ ego analogues nke "Mikardis Plus" na-adabere na onye nrụpụta ha, na mgbakwunye, na nhazi nke mbadamba. N'ihe dị ala ma ọ bụ nke dị ala karịa, ị nwere ike ịzụta, dịka ọmụmaatụ, ọgwụ dịka Angiakand, Valz na Blocktran. Ntụziaka maka iji analogues kwesịkwara ịmụ, ebe ọ ga - eme ka ọ kwe omume ịchọpụta contraindications niile na nuances eji.

Ime na lactation

Womenmụ nwanyị dị ime na-eji Mikardis Plus eme ihe. Agaghị anabata nnabata ndị nabatara ndị na-anabata A-II n’oge ọnwa atọ nke mbụ. Maka nkwenye nke afọ ime, a ga-akwụsị iji ọgwụ ndị a ozugbo. Ọ bụrụ na ọ dị mkpa, a na-enye ndị ọrịa ọgwụ ọgwụ mgbochi ọzọ nwere aha nchekwa nchekwa n'oge afọ ime.

Na II - III trimesters, ọgwụgwọ na A-II nnabata ihe mgbochi na-contraindicated, n'ihi na n'oge ọmụmụ ọmụmụ a chọpụtara na n'oge ndị a oge nke ime ha nwere ike ime ka fetotoxicity na mmadụ (egbu oge ossification nke okpokoro isi, oligohydramnion, isi akụrụ ọrụ mkpịsị), yana nke amụba toonity (hyperkalemia, hypotension, renal ọdịda). Ọ bụrụ na enyere ndị antagonists nke A-II ọrụ ka ekwuputara n’oge ọnwa nke abụọ nke ịtụrụ ime, a ga-eme nyocha nke ultrasound nke ọkpụkpụ nke okpokoro isi na ọrụ akụrụ n’afọ nwa ebu n’afọ. Ndi amuru ohuru ndi nne ya drugsuru ogwu a kwesiri ileba anya nke oma.

Ahụmịhe nke iji hydrochlorothiazide n'ime ụmụ nwanyị dị ime, ọkachasị n'oge ọnwa atọ. A maara na ihe a na - agafe site na mgbochi nke placental ma, na - eburu n'uche usoro ọgwụ nke ihe omume ya, enwere ike ịtụ anya na iwere Mikardis Plus na II - III trimesters nke afọ ime nwere ike ịkpasu mmebi nke nsị nke fetoplacental ma kpata mmetụta ndị na - adịghị mma na akpa nwa na nwa ebu n'afọ, dịka thrombocytopenia, jaundice, elektrọnte elektrik. Ekwesighi iji Hydrochlorothiazide maka ọbara ọgbụgba na edema n'ihi afọ ime, maka preeclampsia (n'ihi ngbanwe nke iyi egwu nke mbelata olu plasma na mbelata nke ọgbụgba placental), na enweghị enweghị mmetụta dị mma n'ọnọdụ ọnọdụ ndị a.

Maka ọgwụgwọ nke ọbara ọgbụgba dị oke mkpa na ụmụ nwanyị dị ime, enwere ike ịkọ hydrochlorothiazide naanị n'ọnọdụ ndị dịkarịsịrị ala, mgbe ọ gaghị ekwe omume iji ọgwụgwọ ọzọ.

Mikardis Plus n'oge na-enye nwa ara bụ nke a machibidoro iwu.

Emebeghị nnyocha banyere ọgwụ ọgwụ ahụ na ọmụmụ ụmụ mmadụ.

Ndi dibia nyocha

Dika ndi okacha mara si kwuo, ogwu a di ezigbo uto. Ọ na - enyere aka ngwa ngwa, adịkarịghị akpata mmeghachi omume anụ ahụ. N'ezie, enwere analogues dị ọnụ ala karịa. Ma ọ bụrụ na inwale ogo dị na ọnụahịa, mgbe ahụ ọgwụ akọwapụtara na nke a na-egosi n'ụzọ zuru oke n'onwe ya.

Anyị enyochaala ntuziaka ngwa na nyocha maka Mikardis Plus.

Na arụ ọrụ ezumike ọrụ

Na ọnụnọ oke nrụrụ akụrụ (CC n'okpuru 30 ml / min), Mikardis Plus na-contraindicated.

Na mkpachapụ anya, a na-atụ aro ka iji ọgwụ hypotensive megide nzụlite akwara akwara nke otu akụrụ ma ọ bụ akụrụ akwara akwara stenosis na ọnọdụ ka ọ gbasesịrị akụrụ. N'ime ndị ọrịa nwere nsogbu nrụrụ akwara dị obere / agafeghị oke (CC dị ka 30 ml / min), a chọghị ịgbanwe Mikardis Plus, mana ha kwesịrị ilebara ọrụ gbasara akụrụ oge ụfọdụ.

Na arụ ọrụ imeju

Na ọnụnọ nke mmebi imeju siri ike (klas C n'ihe banyere -mụaka-Pugh), a machibidoro iji Mikardis Plus ike.

Ndị ọrịa nwere nsogbu imeju na-arụ ọrụ ma ọ bụ ọrịa imeju na-aga n'ihu (Childmụaka na Pugh klas A na B) kwesịrị iji ọgwụ na-akpachara anya, ebe ọ bụ na n'agbanyeghị obere mgbanwe na nguzo mmiri-electrolyte, enwere ohere nke ịmalite ọrịa hepatic. N'ihe banyere ọrụ imeju na-arụ ọrụ nke ogo / obere ogo, oke ọgwụ kwa ụbọchị Mikardis Plus ekwesịghị gafere 40 / 12.5 mg.

Mgbapụta Mikardisplyus, nkwakọ ngwaahịa ọgwụ na ihe mejupụtara.

Mbadamba nkume ndị ahụ bụ oval, biconvex, okpukpu abụọ (otu oyi akwa bụ pinkish-beige na agba, nke ọzọ na-acha ọcha na agba yana enwere ogbe ya na agba pinkish beige), akara ya bụ “H4” na akara ụlọ ọrụ dị na elu ọcha. Taabụ 1 telmisartan 40 mg hydrochlorothiazide 12.5 mg
Ndị pụrụ iche: povidone, meglumine, sodium hydroxide, sorbitol, magnesium stearate, microcrystalline cellulose, iron ironide, sodium sitos glycolate, lactose monohydrate, ọka ọka.
7 pcs - blisters (2) - ngwugwu nke kaadiboodu.
7 pcs - blisters (4) - ngwugwu nke kaadiboodu.
7 pcs - blisters (8) - ngwugwu nke kaadiboodu.
7 pcs - blisters (12) - ngwugwu nke kaadiboodu.
Mbadamba nkume ndị ahụ bụ oval, biconvex, okpukpu abụọ (otu oyi akwa bụ pinkish-beige, nke ọzọ na-acha ọcha na enwere ike iburu pinkish-beige), n’elu ala ọcha bụ akara "H8" na akara ụlọ ọrụ. Taabụ 1 telmisartan 80 mg hydrochlorothiazide 12.5 mg
Ndị pụrụ iche: povidone, meglumine, sodium hydroxide, sorbitol, magnesium stearate, microcrystalline cellulose, iron ironide, sodium sitos glycolate, lactose monohydrate, ọka ọka.
7 pcs - blisters (2) - ngwugwu nke kaadiboodu.
7 pcs - blisters (4) - ngwugwu nke kaadiboodu.
7 pcs - blisters (8) - ngwugwu nke kaadiboodu.
7 pcs - blisters (14) - ngwugwu nke kaadiboodu.

Nkọwa ọgwụ a sitere na ntuziaka masịrị iwu maka iji ya eme ihe.

Ihe ndị a na-ahụ maka ọgwụ na Mikardisplyus

Ọgwụ antihypertensive. Ọ bụ nchikota nke telmisartan (onye anakpo angiotensin II) na hydrochlorothiazide - thiazide diuretic. N'otu oge, ejikọtara ihe ndị a n'otu n'otu na-eduga n'ịba ụba antihypertensive karịa iji otu n'ime ha iche iche. Mbanye MikardisPlyus 1 oge / ụbọchị na-eduga na mbelata ọbara mgbali elu.
Telmisartan bụ onye na - emegidekarị ndị nnabata angiotensin II. Ọ nwere oke mmekọrịta maka AT1 receptor subtype nke angiotensin II, site na nke a na-ahụ ihe omume nke angiotensin II. Telmisartan na-ewepu angiotensin II site na njikọ ya na onye na-anabata ya, na-enweghị ọrụ onye na-ahụ maka nnwere onwe n'ihe metụtara onye nnabata a. Telmisartan na-ejikọ naanị na AT1 receptor subtype nke angiotensin II. Bgba agba na-aga n'ihu. Telmisartan enweghị mmekọrịta maka ndị na-anabata ndị ọzọ (gụnyere ndị na-anabata AT2) nke angiotensin. Amamịghe ọrụ nke ndị nnabata ndị a, yana nsonaazụ nke ike ha nwere na angiotensin nke abụọ, amụchaghị nke na-abawanye na nhọpụta nke telmisartan. Telmisartan na-eduga n'ịbelata ọkwa aldosterone dị n'ọbara. Telmisartan anaghị egbochi renin n'ime ọbara na ọsị ion, anaghị egbochi ACE, anaghị egbochi bradykinin.
N'ime ndị ọrịa nwere ọbara mgbali elu, telmisartan na-ebelata systolic na ọbara mgbali, na-enweghị emetụta mmetụ obi.
Telmisartan na dose 80 mg kpamkpam egbochi mmetụta ọbara mgbali nke angiotensin II. Omume ya dị ihe karịrị awa 24, gụnyere awa anọ ikpeazụ gara aga tupu ị takingụọ ọgwụ ọzọ. A na-achọpụta mmalite nke hypotensive n'ime ọnwa 3 mgbe nchịkwa izizi nke telmisartan. N'ihe banyere kagbuo telmisartan na mberede, ọbara mgbali jiri nwayọ laghachi ọkwa mbụ ya na-enweghị mmepe nke ọrịa mwepụ.
Hydrochlorothiazide bụ thiazide diuretic. Thiazide diuretics emetụta reabsorption nke electrolytes n'ime akụrụ renal, na-abawanye mkpachapụ nke sodium na chlorides (ihe dị ka nha). Mmetụta diuretic nke hydrochlorothiazide na-eduga ná mbelata bcc, mmụba na ọrụ plasma renin, mmụba na nzuzo nke aldosterone ma na-esokwa mmụba na potassium na bicarbonates, yana hypokalemia. Site na nlekọta nke telmisartan n’otu oge, enwere echiche nke ịkwụsị potassium na-akpata site na diuretics ndị a, dịka a ga-eme ka ọ bụrụ ihe gbochiri usoro renin-angiotensin-aldosterone.
Ogologo oge iji hydrochlorothiazide na-ebelata ihe egwu nke ọrịa obi na onwu site na ha.
Mgbe iwere hydrochlorothiazide, diuresis na-abawanye mgbe oge awa abụọ gasịrị, a na-ahụkwa mmetụta kachasị mgbe ọ gachara awa 4. Mmetụta diuretic nke ọgwụ ahụ na-adịgide ruo ihe dịka awa 6-12.
Mmetụta antihypertensive kachasị nke MikardisPlus na-abụkarị izu anọ ka mmalite nke ọgwụgwọ gasịrị.

Usoro onunu ogwu na uzo icho ogwu a.

Ekwesịrị iwere MikardisPlus ọnụ 1 oge / ụbọchị, n'agbanyeghị nri.
Enwere ike inye Mikardis Plus 40 / 12.5 mg maka ndị ọrịa na-eji ọgwụ Mikardis mee ihe na 40 mg ma ọ bụ hydrochlorothiazide adịghị eduga n'ịchịkwa ọbara nke ọma.
Enwere ike inye Mikardis Plus 80 / 12.5 mg maka ndị ọrịa na-eji ọgwụ Mikardis na-eji 80 mg ma ọ bụ Mikardis Plus 40 / 12.5 mg anaghị eduga n'ịchịkwa ọbara mgbali zuru oke.
Site na arụ ọrụ mkpokọta dị nro ma ọ bụ agafeghị oke, a chọghị mgbanwe mgbanwe dose. N'ime ndị ọrịa dị otú a, a ga-enyocha ọrụ ezumike.
N'ime ndị ọrịa nwere ọrịa imeju dị nro ma ọ bụ nke na-adịghị ala ala, ekwesighi iji MikardisPlus mee ihe kwa ụbọchị karịa 40 / 12.5 mg.
Achọghị mgbanwe n’usoro usoro onunu ogwu n’ebe ndị ọrịa nọ.

Mmetụta ọzọ Mikardisplyus:

Nsonaazụ a na-atụ anya na ahụmịhe na telmisartan
Site na sistem iku ume: oria nke akụkụ akụkụ iku ume nke elu (nke gụnyere bronchitis, pharyngitis, sinusitis), mkpụmkpụ ume.
Site na sisitemu obi: bradycardia, tachycardia, mbelata ọbara mgbali elu, mgbu obi.
Site n'akụkụ nke sistemụ akwara na akụkụ ụjọ ahụ: oke egwu, mmetụta nke ụjọ, ịda mba, nkụda mmụọ, nkụ, na ehighị ụra nke ọma.
Site na usoro nri: ọnụ akọrọ, flatulence, vomiting, imeju na-arụ ọrụ.
Site na sistemụ urinary: nnukwu nsogbu gbasara akụrụ.
Site na usoro endocrine: mwepu nke nchịkwa nke hypoglycemia na ọrịa shuga mellitus, nsị nke glucose na-akpata.
Site na sistemụ hemopoietic: eosinophilia, mbelata hemoglobin, thrombocytopenia.
Site na usoro akwara: arthralgia, ogbu na nkwonkwo, azụ mgbu, mgbu mgbu ụkwụ, myalgia, ụdọ na-egbu mgbu mọzụlụ nwa ehi (krampi), ihe mgbaze ndị yiri akwara, adịghị ike.
Site n'echiche ziri ezi: acuity visual achoity, vertigo.
Site n'akụkụ nke metabolism: hypercholisterinemia, hyperuricemia, hypokalemia, hyperkalemia, hypercalcemia, ụba ọkwa uric acid, creatinine, enzymes imeju, CPK ọbara.
Mmeghachi omume nfụkasị: eczema, erythema, pruritus, angioedema, urticaria na mmeghachi omume ndị ọzọ yiri ya (dịka nke iji antagonist II nke antagonist).
Ndị ọzọ: mgbaàmà ndị yiri flu, mmụba ọsụsọ, ikike ibelata.
A na-atụ anya mmetụta ndị ọzọ site na ahụmịhe hydrochlorothiazide
Site na sistem iku ume: dyspnea, nsogbu nke iku ume (gụnyere oyi baa na ure).
Site na usoro akwara obi: arrhythmias, hyperension orthostatic, negiros necrotic.
Site n'akụkụ nke usoro ụjọ ahụ: excitability, echiche nke ụjọ, nkụda mmụọ, echiche nke ụjọ, ịma jijiji mgbe ị na-eje ije, paresthesia.
Site na usoro nri: afọ mgbu, afọ ọsịsa, dyspepsia, gastritis, anorexia, enweghị agụụ, sialadenitis, afọ ntachi, pancreatitis, ọrụ imeju na - arụ ọrụ, jaundice (hepatocellular ma ọ bụ cholestatic).
Site na usoro endocrine: mwepu nke nchịkwa nke hypoglycemia na ọrịa shuga mellitus, nsị nke glucose na-akpata.
Site na akwara anụ ahụ: oge dị anya na-ahụ ọhụhụ, xanthopsia, vertigo.
N'akụkụ nke metabolism: hypercholisterinemia, hyperuricemia, hypokalemia, hyponatremia, mbelata na BCC, metabolism electrolyte na-akpata, hyperglycemia, mmụba nke triglycerides, glucosuria.
Site na sistemu hemopoietic: ọrịa aplastic anaemia, hemolytic anaemia, mgbochi nke ụmị ọkpụkpụ, leukopenia, neutropenia, agranulocytosis, thrombocytopenia.
Site na usoro urinary: ọrịa nke usoro urinary, nephritis interstitial, ọrụ akwara nwere nsogbu.
Site na usoro akwara: adịghị ike, spasm muscle.
Mmeghachi omume nfụkasị: mmeghachi omume anaphylactic, eczema, lupus-like reaction, vasculitis, photoensitivity reactions, ihe ọkụ ọkụ, iwepụta nke anụ ahụ nke SLE, necrolysis na-egbu egbu, angioedema, urticaria na mmeghachi omume ndị ọzọ yiri ya (dịka ọ dị na ojiji nke angiotensin II antagonists).
Ndị ọzọ: mgbaàmà ndị dị ka ahụ ọkụ, ahụ ọkụ, nwere mbelata.

Ntụziaka pụrụ iche maka ojiji nke Mikardisplyus.

N'ime ndị ọrịa nwere ọrụ imeju na-arịa ọrịa ma ọ bụ ọrịa imeju na-aga n'ihu, ekwesịrị iji MikardisPlus jiri nlezianya mee ihe, ebe ọ bụ na obere mgbanwe na mmiri-electrolyte nwere ike inye aka na mmepe nke hepatic coma.
N'ime ndị ọrịa nwere akwara mkpụrụ ndụ akwara stenosis ma ọ bụ stenosis akwara nke naanị akụrụ na-arụ ọrụ, na-eji telmisartan enwekwu ohere nke nnukwu ọgbụgba ọbara na ọdịda akụrụ.
Enweghị ahụmịhe MikardisPlus n'ime ndị ọrịa nwere nnukwu ọrụ mkpo ya ma ọ bụ na ndị ọrịa mgbe a gbasesịrị akụrụ. Ebe ọ bụ na ahụmịhe nke iji MikardisPlus na ndị ọrịa nwere obere mkpo ya na arụ ọrụ obere obere, n'ọnọdụ ndị dị otú a, a na-atụ aro mkpebi oge nke potassium na ọkwa creatinine. Ojiji hydrochlorothiazide na ndị ọrịa nwere nsogbu gbasara akụrụngwa nwere ike ibute azotemia. A na-atụ aro maka oge ọrụ nke akụrụngwa.
Ndị ọrịa nwere oke BCC na / ma ọ bụ hyponatremia nke sitere na usoro ọgwụgwọ diuretic, igbochi oriri nnu, afọ ọsịsa, ma ọ bụ ọgbụgbọ nwere ike ịmalite hypotension arterial hypotension, karịsịa mgbe ị takingụsịrị ọgwụ mbụ. Tupu iji MikardisPlus, mgbazi nke nsogbu ndị a dị mkpa.
N'ọnọdụ ebe ụda olu na ọrụ akụrụ na-adabere na ọrụ nke sistemụ renin-angiotensin-aldosterone (dịka ọmụmaatụ, na ndị ọrịa nwere nnukwu obi nkụchi ma ọ bụ ọrịa akụrụ, gụnyere akụrụ akwara stenosis), iji ọgwụ eme ihe, nke na-emetụta steeti nke usoro ihe a, enwere ike isoro ya na mmepe nke hypotension hypotension, hyperazotemia, oliguria, ma ọ bụ n'ọnọdụ adịghị adị, nnukwu ọdịda gbasara akụrụ.
N'ime ndị ọrịa nwere ọrịa mbụ aldosteronism, ọgwụ antihypertensive, usoro nke iji gbochie ọrụ nke usoro renin-angiotensin-aldosterone adịghị arụ ọrụ. N'ụdị ndị ahụ, akwadoghị nhọpụta MikardisPlus.
N'ime ndị ọrịa nwere aortic ma ọ bụ mitral stenosis ma ọ bụ mgbochi cardioyopathy hypertrophic, ojiji nke MikardisPlus (dị ka vasodilators ndị ọzọ) chọrọ nlekọta pụrụ iche.
Ojiji nke thiazide diuretics nwere ike belata nnabata glucose.
N'ime ndị ọrịa nwere ọrịa mellitus, enwere ike ịchọrọ mgbanwe insulin ma ọ bụ onodu hypoglycemic ọgwụ. N'oge ọgwụgwọ hydrochlorothiazide, ụdị ọrịa shuga nwere ike ịmịpụta.
N'ọnọdụ ụfọdụ, ojiji nke hydrochlorothiazide nwere ike ịmalite hyperuricemia na gout.
Mgbe ị na-eji MikardisPlus, mkpebi oge nke ogo electrolytes n'ọbara ọbara dị mkpa.
Thiazide diuretics, incl. hydrochlorothiazide, nwere ike ịkpata ọgba aghara na electrolyte itule na KShchR (hypokalemia, hyponatremia na hypochloremic alkalosis). Ihe mgbaàmà nke nsogbu ndị a bụ ọnụ akpịrị, akpịrị ịkpọ nkụ, adịghị ike nke izugbe, ịda mbà, ụra, ụjọ, myalgia ma ọ bụ ntanetị akwara nke nwa ehi, ike ọgwụgwụ, hypotension, oliguria, tachycardia, ọgbụgbọ, ma ọ bụ ọgbụgbọ.
Mgbe ị na-eji hydrochlorothiazide, hypokalemia nwere ike ịmalite, mana telmisartan n'otu oge nwere ike belata nsogbu a. Ihe ize ndụ nke hypokalemia kachasị na ndị ọrịa nwere ọrịa cirrhosis, na ịba ụba diuresis, yana ụgwọ ezughi oke nke electrolytes, yana n'ihe banyere n'otu oge nke GCS ma ọ bụ ACTH. Telmisartan, nke bụ akụkụ nke MikardisPlus, na ntụle, nwere ike ibute hyperkalemia n'ihi antagonism na angiotensin II. Agbanyeghị na enwebeghị akuko hyperkalemia dị n'ụlọ ọgwụ site na iji Mikardis Plus, ekwesịrị iburu n'uche na ihe ndị dị ize ndụ maka mmepe ya gụnyere akụrụ gbasara akwara na / ma ọ bụ nkụda obi na ọrịa shuga mellitus.
Enweghị ihe akaebe na MikardisPlus nwere ike belata ma ọ bụ gbochie hyponatremia nke diuretics kpatara. Enweghị kloride na-adịkarị obere ma ọ chọghị ọgwụgwọ.
Hydrochlorothiazide nwere ike belata excretion nke calcium na ihe kpatara (na enweghị nnabata nke metabolic nke ion a) oge dị ntakịrị na mmụba nke ọkwa calcium. Nnukwu hypercalcemia dị ịrịba ama nwere ike ịbụ akara nke hyperparathyroidism na-adịte aka. Tupu ikpebie ọrụ nke glands parathyroid, ekwesịrị ịkagbu thiazide diuretics.
Egosiputara ya na hydrochlorothiazide na-abawanye mmiri nke magnesium na mmamiri, nke nwere ike ibute hypomagnesemia.
N'ime ndị ọrịa nwere ischemic cardiopathy ma ọ bụ ọrịa obi, ọgwụ ọ bụla antihypertensive banyere ikpe mbelata ọbara mgbali elu nwere ike ibute infarction myocardial ma ọ bụ ọrịa strok.
Usoro a na-atụ aro kwa ụbọchị nke Mikardis Plus 40 / 12.5 ma ọ bụ 80 / 12.5 nwere 169 ma ọ bụ 338 mg nke sorbitol, n'otu n'otu. Ya mere, ọgwụ a contraindicated na ndị ọrịa na-eketa fructose ekweghị ibe nọrọ.
Mmeghachi omume hypersensitivity na hydrochlorothiazide nwere ike ịda, ọkachasị ndị ọrịa nwere ọrịa azụ ma ọ bụ ụkwara ume ọkụ.
Enwere ike iji MikardisPlus mee ihe, ma ọ bụrụ na ọ dị mkpa, na njikọ ọgwụ ọzọ na - egbochi ọgwụ mgbochi.
Mgbe ejikọtara ya na Mikardis Plus, a na-atụ aro potassium-diuretics, laxatives, corticosteroids, ACTH, amphotericin, carbenoxolone, penicillin G (sodium salt), salicylic acid na ihe ndị a na-eme, ịgbadochi potassium anya na plasma ọbara.
Site na iji Mikardis Plus na ọgwụ dọkụment na-eme ka ihe na-egbu egbu, na-eme ka potassium sie ike, ọgwụ ndị ọzọ nwere ike ịbawanye ọdịnaya potassium na ọbara ọbara (dịka ọmụmaatụ, sodium heparin), ma ọ bụ mgbe eji ntụ ọka potassium dochie sodium chloride, ị na-agbadochi anya ọkwa nke potassium na plasma ọbara.
Ọ bụrụ n’ịchọrọ iji nkwadebe calcium, ị kwesịrị ị na-enyocha oge ịchekwa calcium n’ọbara na, ọ bụrụ na ọ dị mkpa, gbanwee usoro ọgwụ ndị a.
Iji Ọrịa edimụaka
Emebebeghị ịdị mma na nchekwa nke iji MikardisPlus na ụmụaka na ndị nọ n'afọ iri na asatọ.
Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa
Emebeghị nnyocha omimi nke ọgwụ a nwere ike ịkwọ ụgbọ ala ma jiri ya rụọ ọrụ. Agbanyeghị, mgbe ị na-anya ụgbọ ala ma jiri usoro rụọ ọrụ, mmadụ kwesịrị icheta ohere ọ nwere ịmalite etolite na ura mgbe ị na-eji ọgwụ MikardisPlus.

Ọgwụ Farmacology

Mikardis Plus bụ ngwakọta nke telmisartan na hydrochlorothiazide. Site na nchịkwa ha n'otu oge, mmetụta antihyertonic siri ike na-amalite. N'ihi ya, a na-achọpụta mbelata nke nrụgide.

Telmisartan bụ nhọrọ angiotensin nhọrọ nke 2 nke na-anabata ihe. Bgba agba na-aga n'ihu. Na mgbakwunye, akụkụ a nwekwara ike belata njikọta nke aldosterone.

Hydrochlorothiazide bụ ụdị nwere ahịhịa thiazide. Ọ na - emetụta ntụgharị nke electrolytes na tubules nke akụrụ, na - eme ka mmịpụta nke sodium chloride na-abawanye ozugbo. Nke a na-ebelata oke olu mgbasa ọbara, na-eme ka njikọ nke aldosterone dịkwuo elu, na-eme ka ọrụ renin dịkwuo elu.

Mgbe nchịkwa ọnụ nke hydrochlorothiazide, diuresis na-ebili ọtụtụ oge, a na-enwekwa mmetụta kachasị mgbe awa ole na ole gasịrị wee ruo awa 12.

Mkparịta ụka ọgwụ ọjọọ

Mmekorita nke puru ime na ojiji nke telmisartan na ogwu ndi ozo.

hydrochlorothiazide, warfarin, digoxin, simvastatin, glibenclamide, amlodipine: ahụghị nnyonye anya mmekọrịta dị oke ọnụ, achọtara mgbanye plasma na digoxin n'ime ọbara n'ihe dị ka 20%, na ijikọtara telmisartan na digoxin, a na-atụ aro ka ya chọpụta oge nke ọkwa nke ikpeazụ n’ọbara,
Ngwakọta lithium: n'ọnọdụ ndị dị obere, mmụba a gbanwere na lithium n'ime ọbara ga-ekwe omume, na-aga n'ihu na-egbu egbu, n'ihe metụtara nlezianya ya na ọbara ahụ,
ọgwụ antihypertensive ndị ọzọ: mmetụta antihypertensive nwere ike ịbawanye elu, yana ngwakọta nke telmisartan na ramipril, a chọpụtara mmụba na AUC_0-24 na C_max nke ikpeazu na metabolite ya (ramiprilat) ugboro abụọ 2.5, amabeghị ịdị mkpa nke mmekọrịta a,
ọgwụ mgbochi na - abụghị steroidal anti-inflammatory (NSAIDs), gụnyere acetylsalicylic acid, nke a na - eji dị ka onye na - ahụ maka mbufụt (na a kwa ụbọchị, ọ bụghị ihe karịrị 3 g): NSAID na - ahọpụtaghị ya na cyclooxygenase-2 inhibitors (COX-2) n'ime ndị ọrịa nwere BCC belata nwere ike ibute mmepe nke nnukwu akwara ọdịda. , ndị ọrụ na-emetụta RAAS nwere ike igosipụta mmetụta synergistic, ya na ngwakọta nke telmisartan na NSAIDs na mmalite ọgwụgwọ, ọ dị mkpa iji kwụọ ụgwọ maka bcc ma nyochaa ọrụ renal, ya na njikọ a site inhibiting prostaglandin vasodilator edinam nke telmisartan, a ọnụ mmetụta mgbe jikọtara na paracetamol na ibuprofen clinically ịrịba mmetụta na-adịghị na-ekpughe.

Njikọ mmekọrịta ga-ekwe omume iji jikọtara hydrochlorothiazide na ọgwụ / ọgwụ ndị ọzọ:

ọgwụ antidiabetic na-a andụ na insulin: idozigharị nke ọgwụ ndị a nwere ike ịdị mkpa,
barbiturates, opioid analgesics, ethanol: ihe egwu nke orthostatic hypotension na-akawanye njọ,
colestyramine, colestipol: a na - emebi ọgba aghara nke hydrochlorothiazide,
metformin: na-eme ka ihe ize ndụ nke lactic acidosis,
pressor amines (gụnyere norepinephrine): imebi ihe nke ndị ọrụ a ga - ekwe omume,
cardiac glycosides: ihe egwu nke ịmalite hypomagnesemia / hypokalemia n'ihi turezide diuretics, yana ọdịdị arrhythmias kpatara site na iji glycosides cardiac, na-aka njọ.
ndị na - anaghị eme ka akwara dị jụụ (gụnyere tubocurarine chloride): enwere ike ịkwalite ọrụ nke ndị ọrụ a,
Nkwado nke calcium: ọkwa calcium nwere ike ịbawanye n'ihi mbelata nke akụkụ ahụ ya site na akụrụ, yana jikọtara nke a, ọ dị mkpa ileba anya mgbe niile itinye uche nke kalsel n'ọbara na, ọ bụrụ na ọ dị mkpa, gbanwee dose ya,
ndị na - egbochi ọgwụ gout: mmụba nke ọkwa uric acid na ọbara ọbara ga - ekwe omume, nke nwere ike ịchọ nhazi usoro nke ndị na - ahụ maka ọrịa uricosuric, mmụba ugboro ugboro nke mmeghachi omume hypersensitivity na allopurinol,
biperidine, atropine na ọgwụ m-anticholinergic ndị ọzọ: a na-ebelata eriri afọ, bioavailability nke thiazide diuretics,
diazoxide, beta-mgbochi: nwere ike ịbawanye hyperglycemia nke ọgwụ ndị a kpatara,
laxatives, mkpụrụ osisi na - ewepu potassium, gluco- na mineralocorticosteroids, amphotericin B, corticotropin, benzylpenicillin, carbenoxolone, ọgwụ nke acetylsalicylic acid na ọgwụ ndị ọzọ na - eduga na ike nke potassium na mmepe nke hypokalemia: mmetụta hypokalemic bụ n'ihi hypokalemic bụ mmetụta hypokalemic bụ n'ihi hypokalemic mmetụta dị na hypokalemic na mmetụta ahụ Telmisartan
NSAIDs: enwere ike ịkụda mmụọ antihypertensive na mmetụta diuretic,
Nmekorita nke potassium, ihe ndi na –eme ka ogwu na ihe ndi ozo nke na-ebute mmụba na ọkwa nke potassium n’ọbara ọbara (heparin), dochie sodium na sodium chloride na potassium salts: hyperkalemia nwere ike ime, nlele oge a na-etinye uche gị na mkpokọta plasma nke potassium na ọbara.
ndị nnọchianya cytotoxic (dịka ọmụmaatụ cyclophosphamide, methotrexate): mwepụta nke ndị ọrụ ndị a na-ebelata ma mmetụta myelosuppressive ha na-abawanye,
glycyrrhizic acid (mgbọrọgwụ licorice): mbelata ọkwa nke potassium na ọbara n'ọbara ga - ekwe omume (mmepe nke hypokalemia),
amantadine: nsogbu nke ihe a na-achọghị ka ọ ka njọ.

Ihe analogues nke Mikardis Plus bu: Telzap Plus, Telsartan N, Telpres Plus, wdg.

Ofzọ nchịkwa na usoro onunu ogwu

Ntụziaka maka ị takingụ ọgwụ na-atụ aro ị thisụ ọgwụ a otu mbadamba otu ugboro n'ụbọchị. Iri nri adịghị mkpa, mana na afọ efu, a na-enweta nsonaazụ ahụ ọtụtụ oge ngwa ngwa.

Mmetụta kachasị, dịka iwu, ana - enweta n’ime otu ọnwa ma ọnwa abụọ ebidochara ọgwụ. Ọ bụrụ na enwere ụdị mkpa ahụ, enwere ike ịgbakwunye ọgwụgwọ ahụ na ọgwụ ndị ọzọ na - enyere aka belata ọbara mgbali n'ime obere oge.

Maka ndị ọrịa nwere ọbara mgbali elu, dọkịta nwere ike ịbawanye usoro onunu ogwu ya ruo mg mg 15 kwa ụbọchị.

Ntị! Hydrochlorothiazide nwere ike imetụta ọnọdụ ọzọ nke onye achọpụtala na mbụ mmebi akụrụ. Ọrịa a, ọ kacha mma ịbanye na loop.

4. Njikota na uzo ndi ozo

Na ngwakọta nke ọgwụ a n'otu oge:

Antihypertensive ọgwụ ọjọọ - enwere ike ịchọpụta mmụba na mmetụta antihypertensive,
Nkwadebe Lithium - enwere ike ịhụ mmụba nke nwa oge a na ọbara,
Digoxin - mmụba nwa oge na mkpokọta nke ihe ikpeazụ mejupụtara n'ọbara site n'ihe ruru pasent 20%,
Site na NSAIDs, a na-ahụ ụdị ọrịa ọdịda akụrụngwa na-arịa ndị ọrịa nwere oke ọbara,
Na barbedi, a na-ahụ ọgwụ mgbu opioid - a na-ahụta orthostatic hypotension,
Metformin - lactic acidosis nwere ike ime
Colestipol na colestyramine - a na - achọpụta mgbochi nke mmiri hydrochlorothiazide,
Insulin ma obu hypoglycemic ọgwụ - mmụba na ọrụ nke ndị ọrụ ikpeazụ,
Ọgwụ mgbochi-gout - enwere ike ịhụ mmụba nke uric acid n'ime ọbara mmadụ
Ndị na - anaghị eme ka akwara dị jụụ - enwere mmụba na arụmọrụ ha,
Nkwadebe Calcium - ị nwere ike ịhụ mmụba nke mkpokọta calcium n'ime ọbara,
Ndị na-ahụ maka M-anticholinergic, dịka ọmụmaatụ, biperiden ma ọ bụ atropine - nwere ike ịbawanye bioavailability nke diuretics thiazide.

Etu esi ewere usọbọ a n’oge ịtụrụ ime.

N'oge afọ ime, a ga-ahapụrịrị nchịkwa ọnụ nke Mikardis Plus.

Nke a bụ n'ihi eziokwu ahụ bụ na ihe na-arụ ọrụ nwere ike ịbanye na obere anụ ahụ, na-arụ ọrụ na-adịghị mma na ya. Na mgbakwunye, ọ nwekwara ike imetụta ọnọdụ izugbe nne.

Mgbe ị na-a breastụ ara, ị ga-ahapụ ike nke ị possibilityụ ọgwụ ahụ. Y’oburu na nnabata a ka di nkpa, ma onweghi nke achoro ya kwesiri ekwesi, yabụ ikwusi inye nwa ara.

7. Nchekwa nke ogwu

A na-etinye ọgwụ a ka ọ dị mma n'ime ụlọ gbara ọchịchịrị nke a ga-echebe site na mmiri ma anwụ. Ebe kachasị mma nwere ike ịbụ mkpuchi. Na mgbakwunye, ịkwesịrị ịgba mbọ hụ na ọgwụ ahụ adaghị n'aka ụmụaka.

Ekwesiri ịchekwa ọgwụ a maka afọ atọ. Ọ bụrụ na ọgwụ a agwụla, mgbe ahụ, akwadoghị ka ojiji ya iji ọzọ.

Maka ngwa a, ọnụahịa nwere ike ịdị iche iche site na mpaghara. Nkwupụta ahụ nwere ọnụ ahịa ego agbagoro na Moscow na Kiev.

Na Ukraine, ịkwesịrị ịkwụ ụgwọ hryvnia 450 maka ọgwụ a.

Ekwesịrị iburu n'uche na dọkịta n'onwe ya ga-emeso nhọrọ nke analog, mana ọ bụghị onye ọrịa.

Enwere ike dochie ọgwụ a dịka Diocor, Valzap Plus, Gizaar, Teveten Plus, Co-Diovan, Valsacor, Atakand Plus, Valz N, Lorista N, Lisinopril, Ibertan, Tareg, Blocktran, Cardosten, Vazotens, Losacor, Valsacor, Kandek , Norotivan, Lozarep, Renikard, Angiakand.

Ọ bụrụ na ị nwere ahụmịhe nke iji ngwaahịa a, hapụzie ntụle maka ọgwụ a.

Nyocha nke ndị ọkachamara n'ihe gbasara obi gbasara ọgwụ Mikardis Plus nwere nkọwa dị mma. Ọ bụrụ na imebi usoro onunu ogwu ma nyocha ya maka ọnụnọ ọrịa nwere ike ịbụ ihe mgbochi na ị Mikụ Mikardis Plus, tupu mbido ọgwụ ahụ, nsonaazụ ahụ agaghị adị oge ịbịa.

Na nke a, nsonaazụ ndị ọgaghị adị obere. Cardiologists kwuru ihe di egwu na onodu obi. N'agbanyeghị na ọbara ọgbụgba na-adịghị ala ala, a na-egosipụta mmetụta dị mma. Ogologo oge a na-ewe ihe dị ka awa iri anọ na asatọ.

Nyocha ndị ọrịa dịkwa mma maka ọgwụ. Nanị ọghọm nke ọgwụ a bụ ọnụahịa ya. Nke bụ eziokwu bụ na ọ bụghị mmadụ niile dị njikere ịkwụ ụdị ego a maka ngwá ọrụ a.

Weputara udi ya na ihe mebere ya

A na-eme ọgwụ ahụ n'ụdị mbadamba ụrọ, nke nwere ogige 2 na-arụ ọrụ - telmisartan na hydrochlorothiazide.

Dika ihe ndi ozo ndi n’eme ka osiso di elu na izuzu, anyi bu:

ọka ọka
mmiri ara ehi shuga
microcrystalline cellulose,
sodium hydroxide
iron oxide dyes,
povidone
sorbitol
meglumine.

Mbadamba na-eji oval nwere biconvex elu. A naghị emepụta ihe na - egbochi ọgwụ n'ụdị ịgba, gel, ma ọ bụ usoro parenteral.

A na-eme ọgwụ ahụ n'ụdị mbadamba ụrọ, nke nwere ogige 2 na-arụ ọrụ - telmisartan na hydrochlorothiazide.

Sistemụ akwara Central

Site na nkụda mmụọ nke sistemụ akwara na mmepe nke nsogbu uche mmadụ, ihe omume ahụ gbanwere - ọnọdụ ịda mba, echiche nke ụjọ na-apụta.

Dizziness, isi ọwụwa, paresthesia, adịghị ike nke izugbe, nsogbu ụra nwere ike ịda.

Mmetụta ikike ịchịkwa usoro

Ọgwụ a anaghị emetụta arụmọrụ sistemụ akwara yana ịrụ ọrụ ọfụma. N'otu oge ahụ, ọ dị mkpa iji lelee anya mgbe ị na-arụ ọrụ na usoro mgbagwoju anya yana mgbe ị na-anya ụgbọ ala, n'ihi na ọ ga-ekwe omume ida mmụọ, ọdịdị nke nsonaazụ ndị ọzọ (iro ụra, nkụda mmụọ). Mmetụta na-adịghị mma nwere ike ibute ịta ụta na ọsọ nke mmeghachi omume psychomotor dị mkpa maka ịnya ụgbọ ala.

Jiri n'oge ime na lactation

Prohibitedmụ nwanyị nọ n’oge ime ka amachibido iwere Mikardis n’ihe gbasara nsogbu dị n’afọ nke nwa ebu n’afọ.

N'ime usoro nke ẹmbrayo, ịtọlite oghere nke akwara na akwara.

Mgbe ị na-anara ọgwụgwọ ọgwụ, ọ dị mkpa ịkwụsị ị breastụ ara.

Mgbe ị na-anara ọgwụgwọ ọgwụ, Mikardis Plus ga-akwụsị ịfeụ ara.

Ndi Okacha Cardio

Elena Bolshakova, dibia bekee, Moscow

Emere m ọmụmụ ihe dị ka akụkụ nke akwụkwọ nyocha na nsonaazụ nke ọgwụ, ya mere enwere m ike iji obi ike kwuo banyere ịdị irè nke Mikardis. Ọgwụ na-enyere aka ime ka nrụgide etiti ọdụ dị belata ma belata mgbasa nke ebili mmiri, nke na-akpalite mmepe nke ọrịa obi. Ọgwụ a dị irè ma ndị na-eto eto ma ndị agadi. Nsonaazụ ndị ga-achọ ọgwụgwọ ọzọ, na amabeghị. Ọgwụ anaghị emetụta ịta.

Sergey Mukhin, dibia bekee, Tomsk

Echere m na ọgwụ ahụ bụ ụzọ dị mma iji belata ọbara mgbali elu. Mgbe ewere ya otu ugboro n’ụbọchị, ọgwụgwọ ahụ na-adịgide otu ụbọchị. Ọnụahịa ahụ dị elu. Ndepụta contraindications buru ibu. Mana ọgwụ dị irè maka ụdị ọrịa shuga 2, ọrịa obi na -akpata. Amachibidoro iji ndị ọrịa ọrịa obi na-adịghị ala ala. A na-ahụtakarị ihe nfụkasị ahụ na omume m.

Enwere ike dochie Mikardis Plus na Pritor, nke edobere ya na ebe dịpụrụ iche na radieshon ultraviolet na okpomọkụ nke + 8 ... + 25 Celsius.

Dmitry Gavriilov, 27 afọ, Vladivostok

Ọbara mgbali elu bidoro, n'ihi nke n'uhuruchi ahụ ike adịghị mma, enweghị ikuku mgbe niile, na arrhythmia bidoro. Ndị dọkịta depụtara mbadamba Mikardis. Ọgwụ malitere ime ihe n’ụbọchị mbụ. Mgbe awa atọ gachara mbadamba nkume ndị ahụ, nsogbu ahụ kwụsịrị maka awa 20 na-esote. N'okwu a, ọ dị mkpa ị medicationsụ ọgwụ ndị ọzọ ga-enyere aka ịnọgide na-enwe mmetụta a. Ana m akwado ịkpọ dọkịta gị maka ọgwụ nri ndị ọzọ ọgwụ nje ndị ọzọ.

Alexandra Matveeva, onye gbara afọ 45, St. Petersburg

Ọbara mgbali agbago agbachachara ịwa ahụ. Ọkpụkpụ akwara ahụ nyere mbadamba MikardisPlus mbadamba ọrụ ogologo oge. Ọ masịrị m ọgwụ ahụ, ọ na-eji nwayọ wedata ọbara ọgbụgba. Nsonaazụ nke ọgwụ anaghị emetụta ahụ ma ọ dịghị akpata nfụkasị, mmeghachi omume anaphylactic. Nrụgide ahụ erutela 130/80 ma nọgide na ọkwa a. Ana m adụ gị ọdụ ka ị were oge izu abụọ tupu ị whenụọ ọgwụ.