Amikacin sulfate (Amikacini sulfas)

Ngwakọta ntụ ntụ maka imepụta usoro ezubere maka nchịkwa ma ọ bụ nchịkwa intramuscular na-acha ọcha mgbe niile ma ọ bụ dị nso na ọcha, hygroscopic.

1000, 500 ma ọ bụ 250 mg nke ntụ ntụ dị na karama dị 10 ml, 1, 5, 10 ma ọ bụ 50 nke karama dị otú ahụ na otu mpempe akwụkwọ.

Ngwọta ahụ (intravenous, intramuscular) na-apụtakarị, ahịhịa na-acha ma ọ bụ na-enweghị ụcha.

Ofdị ntọhapụ na mbadamba ihe adịghị.

Mlọ ọgwụ

Amikacin (aha ya na uzommeputa ya na Latin Amikacin) bu nke eji eme ya aminoglycoside (ọgwụ nje) ime ihe banyere otutu oria. Ndi nwere ọgwụ nje emereme. Ọ na-abanye ngwa ngwa site na mgbidi sel nke pathogen, na-ejikọ ya ike na mpaghara nke 30S ribosome nke mkpụrụ ndụ nje ma na-egbochi proteinsynthesis protein.

Ihe ekwuputara na mmetụta gram na-adịghị mma aerobic pathogens: Salmonella spp., Enterobacter spp., Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, Shigella spp., Serratia spp., Providencia stuartii.

Ngwa ngwa ike megide bacteria gram-positive: Staphylococcus spp. (gụnyere ụdọ na-eguzogide ọgwụ methylene), ọtụtụ ụdị Ike kọmputa spp.

Bacteriamụ nje aerobic enweghị mmetụta na amikacin.

Mlọ ọgwụ

Mgbe nchịkwa intramuscular, ọ na-etinye obi gị dum na ọkwa zuru oke nke enyere ya. Na-abanye n'ime akwara niile na site na mgbochi. Indrachi protein na-emetụta ọbara ruru 10%. Onweghi mgbanwe. Ọ na-apịpụta ya n’aka akụrụ na-agbanweghi. Iwepu ọkara ndụ na-abịarute awa 3.

Ihe ngosi Amikacin

Ngosipụta nke iji Amikacin bụ ọrịa na-efe efe na-akpata ọrịa microorganisms (gram-negative gram). gentamicin, kanamycin ma obu sisomycin) ma ọ bụ n'out oge gram-nke oma na gram-microorganisms:

• akụkụ okuku ume na ọrịa (ka oyi baa, ọgbụgba nke pleura, bronchitis, ọnya afọ),
• sepsis,
• na-efe efe endocarditis,
• ụbụrụ ụbụrụ (gụnyere meningitis),
• urinary tract na-efe efecystitis, pyelonephritis, urethritis),
• afọ ime (gụnyere peritonitis),
• anụ ahụ dị nro, anụ ahụ dị n'okpuru ala na akpụkpọ ahụ nke agwa purulent (gụnyere ọnya afọ, ọnụnọ, nsogbu ọnya),
• ọrịa nke sistemụ hepatobiliary,
• nkwonkwo na ọnya nkwonkwo (gụnyere osteomyelitis),
• merụrụ ọnya
• ọrịa na-efe efe postolowo.

Nsonaazụ

• Mmeghachi omume nfụkasị ahụ: ahu ọkụ, ihe nwu, itching, angioedema.
• Ihe mmezi usoro mmeghachi omume: hyperbilirubinemiaya hepatic transaminases, ọgbụgbọ, ọgbụgbọ.
• Mmeghachi omume site na sistemu hematopoietic: leukopenia, granulocytopenia, anaemia, thrombocytopenia.
• Mmeghachi omume sitere na usoro ụjọ ahụ: mgbanwe mgbanwe nke akwara ozi, iro ụra, isi ọwụwa, ntị ịnụ ihe (ntị nwere ike), ọgba aghara nke ngwa agha vestibular.
• Site na usoro mkpụrụ ndụ: proteinuria, oliguria, microhematuriagbasara akwara.

Ntụziaka maka iji Amikacin (Usoro na usoro onunu ogwu)

Gbanye ntuziaka Amikacin maka iji enye gị ohere ịnye ọgwụ ahụ intramuscularly ma ọ bụ intravenously.

Formdị usoro ọgwụgwọ a dị ka mbadamba maka nchịkwa ọnụ adịghị adị.

Tupu ntụtụ, ọ dị mkpa ịrụ nnwale intradermal maka ịdị nkọ nke ọgwụ, ma ọ bụrụ na enweghi contraindications maka arụmọrụ ya.

Kedu otu esi esi azụta Amikacin? A kwadebere ihe ngwọta nke ọgwụ ahụ tupu nchịkwa site na iwebata 2-3 ml nke mmiri distilled nke achọrọ ntụtụ n'ime ihe vial ahụ. A na-ahazi azịza ya ozugbo ịkwadebe ya.

Usoro onodu odi nma maka ndi okenye na umuaka site na otu onwa bu 5 mg / kg ugboro ato kwa ubochi ma obu 7.5 mg / kg ugboro abuo maka ubochi iri.

Oke kachasị maka ndị okenye kwa ụbọchị bụ 15 mg / n'arọ, kewara abụọ na injections. N'okwu dị oke njọ na ọrịa nke Pseudomonas kpatara, a na-ekewa usoro kwa ụbọchị gaa na nchịkwa atọ. Usoro kachasị elu nke enyere maka usoro ọgwụgwọ dum ekwesịghị ịdị karịa gram 15.

Emere umu ohuru n’ime 10 mg / n'arọ, ma ghazie 7.5 mg / kg maka ubochi iri.

Mmetụta ọgwụgwọ na-apụtakarị n'ime ụbọchị 1-2, ma ọ bụrụ na mgbe ụbọchị 3-5 gasịrị mmalite ọgwụgwọ, a hụghị mmetụta nke ọgwụ ahụ, ọ ga-akwụsị ma jiri usoro ọgwụgwọ gwọọ ya.

Dodoụbiga ya ókè

Ihe ịrịba ama: ataxiaokfu nụ anya ntughari, akpịrị ịkpọ nkụ, ọgba aghara nke urination, vomiting, ọgbụgbọ, tinnitus, okuku ume.

Ọgwụgwọ: maka ịkwụsị nsogbu mbufe akwara ịba ọcha n'anyannu kalshial, ndị na - anticholinesterase, A na-eme ka ikuku na-arụ ọrụyana usoro ọgwụgwọ ọrịa Symptomatic.

Mmekorita

Mmetụta Nephrotoxic ga-ekwe omume mgbe ị na-eji vancomycin, amphotericin B, methoxyflurane,X-ray ndị na-ahụ maka ọdịmma, ọgwụ mgbochi-anaghị egbochi steroidal, enflurane, cyclosporine, cephalotin, cisplatin, polymyxin.

Ototoxic enwere ike mgbe ị na-eji ya ethaclates acid, furosemide, cisplatin.

Mgbe ejikọtara ya na penisilini (ya na mmebi akụrụ) nsonaazụ antimicrobial belatara.

Mgbe ị na-eso ya neuromuscular blockers na ethyl ether enwere ike ịda mbà nke iku ume na-abawanye.

Anabataghị Amikacin ka agwakọta ya na usoro ya na cephalosporins, penisilini, amphotericin B, erythromycin, chlorothiazide, heparin, thiopentone, nitrofurantoin, tetracyclines, vitamin sitere na B, acid nke ascorbic na potassium chloride.

Amikacin analogues

Analogs: Sọlfọ Amikacin (ntụ ntụ maka ihe ngwọta) Ambiotic (ịgba ntụtụ) Amikacin-Kredofarm (ntụ ntụ maka ihe ngwọta) Loricacin (ịgba ntụtụ) Flexelite (ihe ngwọta maka injection).

N'ihi nnabata nri niile aminoglycosides Amikacin analogues adịghị na eriri afọ dị na mbadamba.

Mụaka na-erubeghị afọ isii ka a na-ekenye ụzọ izizi nke 10 mg / kg, mgbe ahụ 7.5 mg / kg ugboro abụọ n'ụbọchị.

Ihe na-egosi Amikacin sulfate

Ọrịa siri ike nke microorganisms nwere mmetụta maka ọgwụ ahụ: sepsis, meningitis, peritonitis, septic endocarditis, ọrịa na-efe efe na akụkụ nke akụkụ okuku ume (oyi baa, akwara umeji, ọnya afọ), akụrụ na urinary tract na-efe efe, nke ka njọ ma na-enwekarị ọria (pyelonephritis, urethritis) ọrịa cystitis), ọnya na-ere ọkụ, wdg.

Usoro onunu ogwu na nhazi

Na / m ma ọ bụ na / n'ime (ntapu). Ndi okenye na ndi toro eto ndi nwere akuko gbasara aru - 15 mg / n'arọ / ubochi (5 mg / n'arọ obula obula ma obu 7.5 mg / n'arọ obula iri na abua), umuaka nwere nkpuru mbu - 10 mg / kg, mgbe ahu 7.5 mg / n'arọ kwa awa 12. Oke kachasị kwa ụbọchị bụ 1.5 g, ngụkọta oge a na-eme ọgwụ agaghị karịa 15. g Ọ bụrụ na enweghị mmetụta ọ bụla, ha na-atụgharị na ọgwụgwọ na ọgwụ ndị ọzọ maka ụbọchị 5. Ogologo oge ọgwụgwọ bụ 7-10 ụbọchị.

Ndị ọrịa nwere ọdịda akụrụngwa chọrọ mbelata dose ma ọ bụ mmụba n'etiti oge n'etiti nchịkwa na-agbanweghị otu usoro. A na-agbakọ oge ahụ site na usoro: serum creatinine concentration x 9. Usoro izizi maka ndị ọrịa nwere nsogbu gbasara akụrụ bụ 7.5 mg / n'arọ, maka mgbako nke usoro ọgwụ na-esote na-eji usoro a: Cl creatinine (mil / min) x mbido ọgwụ (mg) / Cl creatinine nkịtị (ml / min).

Nchedo nchekwa

N'ime ndị ọrịa na-enyocha aminoglycosides ndị ọzọ, mmeghachi omume nfụkasị amikacin nwere ike ịmalite. Mgbe mmeghachi omume nfụkasị ahụ mere, a na-akagbu ọgwụ ahụ ma diplọhydramine, kalsia kloride, wdg. Iji gbochie nsogbu, a na-atụ aro ka ị theụ ọgwụ ahụ n'okpuru nchịkwa akụrụ, ịnụ ntị na ọrụ vestibular (ọbụlagodi 1 oge kwa izu). Ihe banyere ọgba aghara na nha ihu igwe na-abawanye na ọdịda akwara. Ohere inweta mmepe nke oto- na nephrotoxicity na-abawanye site na iji ogologo oge na nnukwu usoro. Na ihe ịrịba ama nke mbụ nke mgbochi nke neuromuscular conduction, ọ dị mkpa ịkwụsị nchịkwa nke ọgwụ ma banye ntụtụ ngwa ngwa iv nke kalsium chloride ma ọ bụ ihe ngwọta nke proserin na atropine, ọ bụrụ na ọ dị mkpa, a na-ebufe onye ọrịa ahụ na iku ume ikuzi.

Ntụziaka pụrụ iche

Tupu ị theụ ọgwụ ahụ, ọ dị mkpa iji chọpụta mmetụta nke microorganisms na ọgwụ nje (jiri diski nwere 30 μg nke amikacin sulfate). Na mpaghara dayameta nke 17 mm ma ọ bụ karịa, a na-ahụ ihe microorganism nwere nlezianya, 15-16 mm nwere mmetụta dị nfe, yana ihe na-erughị 14 mm kwụsiri ike. N'oge ọgwụgwọ, a ga-enyocha ọdịnaya nke ọgwụ nje na plasma ọbara (nyocha ahụ ekwesịghị gafere 30 μg / ml).

Maka nchịkwa intramuscular, a na-eji ihe edozi kwadebere na mbụ site na lyophilized ntụ ntụ na mgbakwunye nke 2-3 milimita mmiri iji gbue ọdịnaya nke vial (250 mg ma ọ bụ 500 mg ntụ ntụ). Maka nhazi iv, wụsa na 200 ml nke 5% gluuze ma ọ bụ 0.9% sodium chloride solution. Ntinye uche nke amikacin na mmezi maka ochichi iv ekwesịghị gafere 5 mg / ml.

Ihe ngbanwe

Hypersensitivity (gụnyere akụkọ ihe mere eme nke aminoglycosides ndị ọzọ), auditory irighiri akwara neuritis, nnukwu akwara na-adịghị ala ala na azotemia na uremia, ịtụrụ ime. Myasthenia gravis, parkinsonism, botulism (aminoglycosides nwere ike ịkpata mmebi nke neuromuscular, nke na-eduga n’ihu na-eme ka uru ahụ ndị ọzọ na-eme ka ọkpụkpụ ghara ịdị gara gara), nkụda mmụọ, ọdịda akụrụ, oge ịmụ nwa, ịmụghị aka nke ụmụaka, ime agadi, lactation.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

V / m, iv (n'ime jet, maka nkeji 2 ma ọ bụ ntapu mmiri), 5 mg / kg kwa awa 8 ma ọ bụ 7.5 mg / n'arọ kwa awa iri na abụọ, nje na-efe efe nke ọnya ọnya (anaghị agbakọ) - 250 mg kwa awa 12 ọ bụla, mgbe emesiri ịba ọcha n'anya, ị nwere ike inye ọgwụ mgbochi ọzọ nke 3-5 mg / kg. Oke kachasị maka ndị okenye dị ihe dị ka 15 mg / kg / ụbọchị, mana ọ karịghị 1.5 g / ụbọchị maka ụbọchị 10.

Ogologo oge ọgwụgwọ ya na a / na ntinye bụ ụbọchị 3-7, yana ụbọchị / m - 7-10.

Maka ụmụ amụrụ, ọgwụ izizi bụ 10 mg / kg, mgbe ahụ 7.5 mg / kg kwa elekere 18-24, maka ụmụ amụrụ ọhụrụ, ọgwụ mbụ bụ 10 mg / n'arọ, mgbe ahụ 7.5 mg / kg kwa awa 12 ọ bụla maka ụbọchị 7-10.

Ndị ọrịa nwere nsogbu gbasara akụrụngwa chọrọ mgbazi nke usoro usoro onunu ogwu.

Ndị ọrịa nwere apa ọkụ nwere ike ịchọ ọgwụ nke 5-7.5 mg / kg kwa awa 4-6 n'ihi obere T1 / 2 (awa 1-1.5) dị mkpụmkpụ n'ime ndị ọrịa a.

Maka nchịkwa intramuscular, a na-eji ihe edozi kwadebere ya na mbụ site na lyophilized ntụ ntụ na mgbakwunye nke 2-3 ml mmiri iji gbue ihe dị na vial (0.25 ma ọ bụ 0,5 g ntụ ntụ). Maka nchịkwa m / v, a na-eji otu ngwọta ahụ eme ihe maka m / m, mgbe ejiri dil 200 m nke dextrose 5% ma ọ bụ 0.9% NaCl ngwọta. Ntinye uche nke amikacin na mmezi maka ochichi iv ekwesịghị gafere 5 mg / ml.

Omume ọgwụ

Mpempe ọgwụ na-acha uhie uhie na-egbu egbu, nje. Site na ịgbanye subS nke 30S nke ribosomes, ọ na-egbochi ịmepụta njem nke ụgbọ njem na onye ozi RNA, na-egbochi mkpokọ protein, ma na-ebibakwa mkpụrụ ndụ nje.

Arụ ọrụ nke ukwuu megide microorganisms nke aerobic gram-Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Salmonella spp., Shigella spp., Grafọdụ micromgangan gram-positive-staphylococcus (gụnyere iguzogide penisilini, ụfọdụ cephalosporins),

arụ ọrụ nwa oge megide Streptococcus spp.

Site na nchịkwa nke oge a na benzylpenicillin, ọ nwere mmetụta synergistic megide njikọta Enterococcus faecalis.

Ọ dịghị emetụta microorganisms anaerobic.

Amikacin anaghị arụ ọrụ n'okpuru ọrụ nke enzymes na-eme ka aminoglycosides ndị ọzọ na-arụ ọrụ, ma nwee ike ịnọgide na-arụ ọrụ megide ụdị Pseudomonas aeruginosa na-eguzogide tobramycin, gentamicin na netilmicin.

Ọgwụ ndị yiri ya:

• Mpempe akwụkwọ nke Augmentin (Augmentin)
• Augmentin ntụ ntụ maka nkwụsị ọnụ
• Mbadamba ụrọ Orzipol (ORCIPOL)
• Dioxidin (Dioxydin) Mouthwash
• Mbadamba nkume nke Tsifran OD (Cifran OD)
• Ọkpụkpọ Gentamicin (Gentamicin)
• Mbadamba ụrọ Amoxicillin Sandoz (Amoxicillin Sandoz)
• Augmentin EU (Augmentin ES) ntụ ntụ maka iji gwọọ ọnya
• Sumamed Aerosol
• Hiconcil Capsule

** Ntuziaka ọgwụgwọ bụ maka ebumnuche ọhụụ. Maka ozi ndị ọzọ, biko rụtụ aka na nkọwapụta onye nrụpụta. Ejila onwe gi ogwu, tupu ịmalite iji Amikacin Sulfate, ikwesiri gakwuru dọkịta. EUROLAB abụghị onye na-ata ahụhụ nsonaazụ ya site na iji ozi ezigara na portal. Ozi ọ bụla dị na saịtị a anaghị agbanwe ndụmọdụ nke dọkịta ma ọ nweghị ike ịbụ nkwa maka mmetụta dị mma nke ọgwụ ahụ.

Interested nwere mmasị na Amikacin Sulfate? Want chọrọ ịmatakwu nkọwa zuru ezu ma ọ bụ ịchọrọ ịhụ dọkịta? Ka ịchọrọ nyocha? Nwere ike gi na dọkịta gharia - Euro ọgwụ ụlọ nyocha mgbe niile n’ozi gị! Ndị dọkịta kachasị mma ga-enyocha gị, nye ndụmọdụ, nye enyemaka dị mkpa ma mee nchoputa. I nwekwara ike kpọọ dọkịta n'ụlọ. Euro Clinic ụlọ nyocha gheghe gi oghe.

** Ntị! Ihe omuma a gosiputara n’ime ndu ogwu a bu ndi okacha amara nke aru ike ya abughi ihe ndabere maka inyocha ogwu. A na-enye nkọwa nke ọgwụ Amikacin sulfate maka akwụkwọ ntụgharị maka ebumnuche ya maka nhọpụta ọgwụgwọ na-ejighi dọkịta. Ndị ọrịa chọrọ ndụmọdụ ọkachamara!

Ọ bụrụ na ị ka nwere mmasị na ọgwụ na ọgwụ ndị ọzọ, nkọwa ha na ntuziaka maka ojiji, ozi gbasara ihe mejupụtara na ụdị ntọhapụ, ihe ngosi maka ojiji na nsonaazụ, ụzọ ojiji, ọnụahịa na nyocha nke ọgwụ, ma ọ bụ nwere nke ọ bụla ajụjụ ndị ọzọ na ntinye - dee anyị akwụkwọ, anyị ga-anwa inyere gị aka.

Mmetụta akụkụ

Site na iji ogologo oge ma ọ bụ ịdoụ mmiri amikacin sulfate nwere ike ịnwe mmetụta pụrụ iche- yana nephrotoxic. Mmeghachi omume ototoxic nke amikacin sulfate ka a na-egosipụta n'ụdị ntị ịnụ (na-adalata elele nke nnukwu azụmaahịa) nke ọgba aghara ngwa. Ihe banyere ọgba aghara na nha ihu igwe na-abawanye na ọdịda akwara. Mmetụta nephrotoxic nke amikacin sulfate bụ mmụba na mkpokoro nitrogen nke ọbara ọbara, mbelata na nwebi nke creatine na, ya na guria, protein with uria, cylindruria and

na-atụgharịkarị. Iji gbochie nsogbu ma belata ugboro ole ha tolitere, a na-atụ aro ka eji ọgwụ eme ihe n’okpuru nchịkwa akụrụ, ịnụ ihe na ngwa ọrụ vestibular (opekata mpe otu izu).

Complicdị nsogbu mgbagwoju anya bụ mgbochi neuromuscular. Usoro nke nsonaazụ a dị nso na ọrụ nke antidepolarizing type muscle relaxants. Na akara mbụ nke mgbochi neuromuscular na-egbochi, ọ dị mkpa ịkwụsị nchịkwa nke amikacin sulfate ma duzie ngwa ngwa klọọkụ chloride ma ọ bụ ọgwụ subcutaneous nke proserin na atropine. Ọ bụrụ na ọ dị mkpa, a na-ebufe onye ọrịa ahụ na iku ume.

Mgbe ị na-eji amikacin sulfate, mmeghachi omume nfụkasị na-enwekwa ike (ọnya anụ ahụ, ahụ ọkụ, isi ọwụwa, wdg). Mgbe ha gosipụtara, a na-akagbu ọgwụ ahụ ma dezie ọgwụ ọgwụgwọ (diphenhydramine, calcium chloride, wdg). Site na nchịkwa nke intravenous nke ọgwụ nje, mmepe nke phlebitis na peripheralitis ga-ekwe omume.

Ajuju, azịza, nyocha banyere ọgwụ Amikacin sulfate

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke kachasi banyere ogwu ahu di na ntuziaka nke ndi emeputaworo.Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.