Ọgwụ Telzap 40: ntuziaka maka ojiji > Ọgwụgwọ na mgbochi

Ọgwụ ahụ dị n'ụdị mbadamba ihe eji eme ihe nkiri: site na edo edo ruo ihe fọrọ nke nta ka ọ bụrụ ọcha, oblong, biconvex, 40 mg nke ọ bụla nwere ahịrị n ’akụkụ ọ bụla, 80 mg nke ọ bụla - nke a na-etinye“ 80 ”(10 PC.). na blisters, na ngwungwu 3, 6 ma ọ bụ 9 blisters na ntuziaka maka iji Telzap).

Otu mbadamba 1 nwere:

ihe na-arụ ọrụ: telmisartan - 40 mg ma ọ bụ 80 mg,
ihe inyeaka: povidone 25, meglumine, sodium hydroxide, sorbitol, magnesium stearate.

Mlọ ọgwụ

Telzap bụ ọgwụ antihypertensive, ihe na - arụ ọrụ ya bụ telmisartan - onye na - emegide ya nke nnabata angiotensin II (subtype AT)₁) Telmisartan nwere mmekọrịta dị elu maka AT₁ (angiotensin) - ndi nwere ncheghari nke eji enyocha ihe anakpo angiotensin II. Na-enweghị ihe onye na - akpata ihe gbasara agonist na-anabata onye na - anabata ya, ọ na - eme ka angiotensin nke abụọ ghara ịdị na njikọ ya ma kechie naanị AT₁ndị na-anabata angiotensin II. Maka ndị ọzọ na-anabata ndị na-anabata angiotensin (gụnyere AT₂ndị na-anabata ya) telmisartan enweghị mmekọrịta. Emebeghị ka ha mata uru ọrụ ha na nsonaazụ nke mkpali nwere ike ime na angiotensin II. Telmisartan na-ebelata ọkwa plasma aldosterone, anaghị egbochi ọwa ion, ọ naghị ebelata ọrụ ntanetị, ọ naghị egbochi ọrụ nke enzyme angiotensin (kininase II), nke na-eweta mbibi nke bradykinin. Nke a na - egbochi mmepe nke ụkwara akọrọ na mmetụta ndị ọzọ na - emetụta ya n'ihi ọrụ nke bradykinin.

Site n'ọbara dị mkpa, ịre Telzap na ọgwụ nke 80 mg na-enye aka igbochi mmetụta ọbara mgbali elu nke angiotensin II. Mmetụta antihypertensive mgbe nchịkwa izizi nke telmisartan pụtara n'ime awa 3 wee dịgide ruo awa 24, na-anọgide na-adịkarị mkpa ruo awa 48. A na - enweta mmetụta antihypertensive ka emesịrị ụbọchị 28-56 nke nchịkwa ọgwụ mgbe niile.

Na ọbara mgbali elu, telmisartan lowers systolic na diastolic ọbara mgbali (BP) na-enweghị emetụta mmetụ obi (HR).

Mkagbu siri ike nke iwere Telzap adịghị eso ya na mmepe nke ọrịa mwepụ, ọbara mgbali jiri nwayọ laghachi ọkwa mbụ ya n'ime ọtụtụ ụbọchị.

Mmetụta antihypertensive nke telmisartan bụ nke a tụnyere ọrụ nke ndị ọrụ antihypertensive dị ka amlodipine, enalapril, hydrochlorothiazide, atenolol, na lisinopril, mana site na iji telmisartan nwere obere okpukpu okpukpu okpukpo na iche na angiotensin na-agbanwe enzyme (ACE) inhibitors.

Ojiji nke telmisartan maka mgbochi ọrịa obi na ọrịa okenye (afọ 55 gbagoro) na ọrịa transient ischemic ọgụ, ọrịa obi na-efe efe, mbibi akwara mkpụrụ obi, ọnya afọ ma ọ bụ nsogbu nke ọrịa shuga 2 (gụnyere ọrịa ọrịa retinopathy, hypertrophy በግራ, akro-maro akụkọ ihe mere eme nke microalbuminuria) nyere aka na mbenata ebumnuche ejikọtara ọnụ: ụlọ ọgwụ n'ihi ọrịa obi na-adịghị ala ala, ọrịa obi ọgụ, infarction myocar. ma ọ bụ a na-abụghị ndị na-egbu egbu ọrịa strok. Mmetụta nke telmisartan yiri ramipril n'ihe banyere ibelata ugboro ole nke isi ihe: ọnwụ obi, infarction myocardial, ma ọ bụ ọrịa strok na-enweghị nsonaazụ na-egbu egbu. N'adịghị ka ramipril, nke telmisartan, ihe kpatara akpịrị akọrọ na ọrịa angioedema dị ntakịrị, ọnya ọgbụgba akwara dị elu.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, nnara nke telmisartan site na eriri afọ na-apụta ngwa ngwa, bioavailability ya bụ 50%. Imekọ nri ọnụ n’otu oge na -ebelata AUC (mkpokọta ụbara plasma), mana n’ime elekere atọ atụnyere telmisartan n’ọbara plasma na-arụkọ ọrụ.

Tụnyere ndị nwoke na ụmụ nwanyị, C_max (ntinye uche kachasị na plasma ọbara) bụ okpukpu atọ dị elu, yana AUC - ihe dị ka ugboro 2, mana nke a anaghị emetụta oke arụmọrụ nke Telzap.

Onweghi nmekorita nke n’agbata ogwu na ogwe ogwu nke ogwu. Mgbe ị na-eji usoro ọgwụ kwa ụbọchị karịa 40 mg C_max na AUC dịgasị iche iche na mmụba ọ̀tụ̀tụ̀.

Ihe ndi ozo n’agbata protein plasma nke ọbara (karisia albumin na alfa)₁acid glycoprotein) - kariri 99.5%.

Ọdịdị pụtara ogo nke ọkara bụ lita 500.

Metabolism nke Telmisartan na-eme site na conjugation na glucuronic acid; conjugate enweghị ọrụ ọgwụ.

Ndi_1/2 (iwepu ọkara ndụ) - ihe karịrị elekere iri abụọ. Ọ na - adịkarịghi agbanwegharị (99%) site na eriri afọ, akụrụ na - erughi 1%.

Mkpochapu plasma zuru oke ruru 1000 ml / min, ọbara ịba ọcha n'anya - ruru 1500 ml / min.

Site n'ịrụ ọrụ mkpado nwere obere, yana ndị ọrịa karịa afọ 65, ọgwụ anaghị agabigaghị ọgwụ, n'ihi ya ọ naghị achọ nhazigharị dose.

Na nnukwu nsogbu akụrụngwa na maka ndị ọrịa ịba n'ọrịa, usoro izizi ekwesịghị gafere 20 mg kwa ụbọchị.

Telmisartan adịghị agwọ ọrịa.

Maka obere nsogbu ịba ọcha n'anya na-agafe agafe (ịhapụ Amụaka-Pugh nke A na B), ekwesịrị iji ọgwụ ruru 40 mg kwa ụbọchị.

Ihe ngosi maka ojiji

ọbara mgbali elu,
mbelata ugboro ugboro ọrịa obi na ọrịa na ndị okenye nwere ọrịa nke ọrịa obi nke ọrịa atherothrombotic etiology (ọrịa obi na-efe efe, mbibi akwara akwara ma ọ bụ akụkọ ọnya isi) yana mmebi anụ ahụ na ụdị ọrịa shuga 2.

Ihe ngbanwe

oke nsogbu ịba ọcha n'anya (Ahụike Childmụaka P),
ọrịa biliary tract ọrịa cholestasis,
n'otu oge ahụ aliskiren na oke mkpọnwụ akụrụngwa GFR (ọnụego nhicha nke ụwa) ihe na-erughị 60 ml / min / 1.73 m 2 nke ahụ dị elu ma ọ bụ bụrụ ọrịa mellitus,
concomitant therapy with angiotensin-converting enzyme (ACE) na-egbochi ndị ọrịa nwere ọrịa nephropathy,
n'ihi na mmadụ nwere ike inweta mkpụrụ osisi
oge ime
inye ara
afọ ruo afọ 18
hypersensitivity na ọgwụ nke ọgwụ.

Ekwesịrị iji ya kpachara anya ma ọ bụrụ na ọ nwere ọrịa obi na-adịghị ala ala, ọbara ọgbụgba hyperrophic, mgbochi na mitral valve stenosis, ọrụ akwara nwere nsogbu, akwara mkpọnwụ akwara, ọnya akwara nke otu akụrụ na-arụ ọrụ, dị nwayọ ruo na-adịghị ala ala ịba ọcha ume, belatara agbasa olu ọbara. ) megide nzụlite nwere obere sodium chloride, afọ ọsịsa, vomiting ma ọ bụ ị diụ ọgwụ, hyperkalemia, hyponatremia, hyperaldost ronism n'oge emesịa ịwa ahụ akụrụ, ojiji nke ndị ọrịa nke agbụrụ Negroid.

Telzap, ntuziaka maka ojiji: usoro na usoro onunu ogwu

Miri mbadamba Telzap ka a na-ewere ọnụ mmiri nwere ọnụ zuru ezu, n'agbanyeghị nri.

Ọtụtụ ọgwụ ị theụ ọgwụ ahụ bụ oge 1 kwa ụbọchị.

Na-atụ aro dosing kwa ụbọchị:

ọbara mgbali ọbara: usoro izizi bụ 20-40 mg. Na enweghị oge zuru oke hypotensive mgbe 28-56 ụbọchị ọgwụgwọ, enwere ike ịba ụba nke mbụ. Oke kachasị kwa ụbọchị bụ 80 mg. Dika ozo, egosiputara ngwakọta nke Telzap na thiazide diuretics (tinyere hydrochlorothiazide),
mbelata onwu na ugboro ole ọrịa obi: 80 mg, na mbido ọgwụgwọ ọ dị mkpa ijikwa ọkwa ọbara mgbali. Ọ bụrụ na ọ dị mkpa, ekwesịrị idozi ọgwụ mgbochi.

Na mmebi akwara siri ike ma ọ bụ ndị ọrịa ịba ha n'ọbara, a na-atụ aro ka ha jiri ọgwụ izizi nke ụbọchị ọ bụla erughi 20 mg.

Maka ịrụ ọrụ ahazi oruru na-agbanwe agbanwe, ọchọghị usoro iji gbanwee ya.

Na obere ọrịa ịba ọcha n'anya na-agafe agafe (nhazi nke ụmụaka-Pugh nke klas A na B), kwa ụbọchị, Telzap agaghị agafe 40 mg.

Nsonaazụ

nkwarụ izugbe: nke oge - asthenia, obi mgbu, ọ na - adịkarịghị - ọrịa na-efe efe,
ọrịa na-efe efe na nje: na - adịghị ala ala - ọrịa urinary tract (gụnyere cystitis), ọrịa okuku ume na elu (gụnyere sinusitis, pharyngitis), adịkarịghị - sepsis (gụnyere ọnwụ),
sitere na akwara obi: ugboro ugboro - bradycardia, hyperension orthostatic, mbelata ọbara mgbali elu, adịkarịghị - tachycardia,
sitere na sisitemu ọbara na ọbara: adịkarịghị - anaemia, adịkarịghị - thrombocytopenia, eosinophilia,
si dịghịzi usoro: adịghị - hypersensitivity mmeghachi omume, anaphylactic Jeremaya,
sitere na psyche: enweghi oge - ịda mba, enweghi nsogbu, ura - nchekasị,
site na akụkụ nke metabolism na nri nri: nke oge - hyperkalemia, adịkarịghị - hypoglycemia megide ọrịa shuga mellitus,
site na akwara afọ: ugboro ugboro - mgbu afọ, ọgbụgbọ, dyspepsia, flatulence, afọ ọsịsa, adịkarịghị - akpọnwụ akpọnwụ, uto na-egbu mgbu, ahụ erughị ala na afọ,
site na sistemụ ịba ọcha n'anya: adịkarịghị - mmebi imeju, nsogbu nke imeju.
site na sistem ụjọ: nwa oge - ada mba, obere oge - ụra ụra,
n’akụkụ akụkụ anụ ahụ na-anụ ihe, ọgba aghara labyrinth: ugboro ugboro - vertigo,
na akụkụ ahụ nke ọhụụ: ọgba aghara a na-ahụ anya,
site na sistem iku ume, obi na akụkụ akụkụ ahụ: n'ime oge - ụkwara, mkpụmkpụ ume, ọ dịkarịsịrị - ọrịa ngụgụ,
mmeghachi omume nke akpụkpọ ahụ: ugboro ugboro - itching, ọnya anụ ahụ, hyperhidrosis, adịkarịghị - ọgwụ ọkụ, urticaria, erythema, eczema, akpukpo aru aru, angioedema (gụnyere nke na-egbu egbu)
sitere na sistemụ urinary: ugboro ugboro - arụ ọrụ ezumike ọrụ na-arụ ọrụ nke ukwuu, akụrụ gbasara akụrụ,
site na mọzụlụ na akwara anụ ahụ: adịghị ala ala - olu mgbu, azụ mgbu (sciatica), myalgia, adịkarịghị - mgbu na nsọtụ, ogbu na nkwonkwo, mgbu akwara (mgbu akwara dị ka ọrịa),
ndị na-egosi ụlọ nyocha: ugboro ugboro - mmụba na plasma plainma, adịkarịghị - mbelata hemoglobin na plasma ọbara, mmụba na ọrụ nke enzyme hepatic na creatine phosphokinase, mmụba nke mkpokọta uric acid na plasma ọbara.

Dodoụbiga ya ókè

Mgbaàmà: mbelata nke ọbara mgbali, tachycardia, dizziness, bradycardia, ịba ụba nke serum creatinine, nnukwu gbasara akụrụ.

Ọgwụ: lavage gastric ozugbo, vomiting nke mmadụ, na-ewere unyi arụ ọrụ. E kwesịrị iji nlezianya nyochaa ịdị njọ nke mgbaàmà ya na ọnọdụ onye ọrịa ahụ. Denye symptomatic na nkwado ọgwụ. Ọ dị mkpa iji hụ na nyocha ọbara mgbe niile maka plasma electrolytes na creatinine. Site n'ịbelata ọbara mgbali elu, a ga-etinye onye ọrịa ahụ site n'ịwelite ụkwụ ya. Na-eme ihe omume iji mejupụta bcc na electrolytes.

Ojiji nke akụrụngwa akwara adịghị mma.

Ntụziaka pụrụ iche

Mgbe ị na-ahọpụta Telzap ndị ọrịa nwere akwara azụ akwara ma ọ bụ stenosis akwara nke akụrụ na-arụ ọrụ, ekwesịrị iburu n’uche na ị theụ ọgwụ ahụ nwere ike ibute oke nsogbu nke nnukwu akwara ike ọgwụgwụ na ọdịda akụrụ.

Bido gwọọ ọgwụ ọgwụ naanị mgbe ị kpochasịrị erughi bcc na / ma ọ bụ sodium dị na plasma ọbara.

A na-atụ aro iji Telzap na ndị ọrịa nwere ọrụ gbasara akụrụngwa ka a na-agbaso ya site na inyocha oge nke ọdịnaya potassium na creatinine na plasma ọbara.

Mgbochi nke RAAS (usoro renin-aldosterone-angiotensin) nwere ike ịdakwasị ndị ọrịa ahụ buru amụma na nke a ma na-ewere telmisartan na ndị ọzọ na-emegide RAAS. Ọ nwere ike ibute ọgbụgba akwara anụ ahụ, nkụda mmụọ, mmepe nke hyperkalemia, yana arụ ọrụ na-arụ ọrụ na-arụ ọrụ (gụnyere nnukwu gbasara akụrụ oke).

Na nkụda obi na-adịghị ala ala, ọrịa akụrụ, ma ọ bụ ọrịa ndị ọzọ nwere oke ịdabere na ọrụ RAAS, nchịkwa Telzap nwere ike ime ka mmepe nke nnukwu akwara hypotension, hyperazotemia, oliguria, na n'ọnọdụ ndị obere, nnukwu ọdịda gbasara akụrụ.

Na hyperaldosteronism bụ isi, ojiji nke ọgwụ adịghị arụ ọrụ.

N'oge ọgwụgwọ na telmisartan na ndị ọrịa na-arịa ọrịa shuga mellitus na-anata insulin ma ọ bụ onodu hypoglycemic na-arịa mmadụ, hypoglycemia nwere ike ime, ya mere achọrọ nlezianya ịchọrọ ọkwa glucose ọbara. Ọ bụrụ na ọ dị mkpa, ekwesịrị imeghari insulin ma ọ bụ ọgwụ hypoglycemic.

Ekwesịrị ilebara anya nke ọma ma ekwesịrị ilebara anya pụrụ iche mgbe a na-ekwupụta Telzap ndị ọrịa nwere oria akwara dịka ọdịda akwara, ọrịa shuga, ndị ọrịa na-a therapyụ ọgwụ ọgwụ na ọgwụ ndị na-akpata oke ụba nke potassium na plasma ọbara, ndị ọrịa agadi (karịa afọ 70), ebe ndị a ụdị dị iche iche nke ndị ọrịa nọ n'ihe egwu dị elu nke ịmalite hyperkalemia, gụnyere ọnwụ.

N'oge ịgwọ ọgwụ ahụ, otu oge nke ọgwụ ndị ọzọ ka aga-eme naanị dị ka dọkịta na-aga ya kwuru.

Mbelata nke ọbara mgbali elu n'oge ọrịa ischemic cardiomyopathy ma ọ bụ ọrịa obi obi nwere ike iduga mmepe nke infarction myocardial infarction ma ọ bụ ọrịa strok.

N'ime ndị ọrịa nke agbụrụ Negroid, a na-ahụta mbelata ọbara na-adịchaghị mma.

Ime na lactation

Ihe ndị dị na mbadamba ụrọ Telzap n'oge mmebi na inye ara na-egbochi imebi.

Mgbe emechara eziokwu nke ịtụrụ ime, ndị ọrịa na-a Telụ Telzap kwesịrị ịkwụsị ọgwụgwọ telmisartan ozugbo ma gbanwee usoro ọgwụgwọ ọzọ antihypertensive ọgwụ nwere profaịlụ nchekwa iji maka n'oge ime na lactation.

Ndepụta nke okwu na analogues nke Telzap

Telpres (mbadamba) → synonym Rating: 29 Isi

Ihe analogue dị ọnụ ala site na 77 rubles.

Emeputa: -
Mwepụta Mwepụta:

Mbadamba ụrọ, 20 mg, Nke 28

Ọnụ ego maka Telpres na ụlọ ahịa ọgwụ: site na 187 rubles. ihe ruru 855 rub. Onyinye (795)
Telpres (synonym) - nke emepụtara na Spen na Saịprọs. Ọ nwere otu ihe eji arụ ọrụ na sistemụ arụmọrụ dị ka telzap. A na - eji ya na ndị ọrịa nwere ọbara mgbali elu, yana ndị mmadụ nọ n'ihe ize ndụ dị elu nke ọrịa obi na - akpata ọrịa atherothrombotic (ischemic stroke, transient ischemic Attack, nnukwu myocardial infarction, ọrịa nke akwara nke ala ala) maka isi ha na mgbochi nsobe, mbelata nkwarụ na ọnwụ. ọrịa ndị a. A na-eji ya egbochi akwara vaskụla nke abụọ na mmepe nke ischemia nke abụọ n’ebe ndị ọrịa nwere ọbara ọbara intracerebral. Ihe ojoo dị nfe dị na anụ ahụ ọkụ na itching, angioedema, mmeghachi omume anaphylactic, ụkwara akọrọ, ọgbụgbọ, ọgbụgbọ, ahụ erughị ala, imi na afọ mgbu, iwetulata ọbara ọgbụgba, ọgbụgba, adịghị ike, ịba ụba ọrụ nke transaminases, urea na creatinine, anaemia, thrombocytopenia. Enweghi ike iji ya mee ihe anagide ya, ihe mgbochi nke biliary tract, hypotension, kelal na hepatic insufficiency, ikike nke akwara nke akwara gbasara akwara obi, ndi anakpo fructose, ndi mmadu noo n’agbata afọ iri na asatọ, ndi nwanyi ndi nwere umu aka na ndi nne.

Ihe analogue dị ọnụ ala site na 70 rubles.

Lorista bụ analogue, onye rụpụtara ya bụ ụlọ ọrụ Slovenian KRKA na ụlọ ọrụ nnọchite anya Russia nke KRKA-RUS. Emepụtara ya n'ụdị mbadamba ụrọ n'ime shei nke 12.5 mg (Nke 30), 25 mg (Nke 30), 50 mg (Nke 30, 60 na 90) na 100 mg (Nke 30, 60 na 90). Ọ na - egbochi ndị na - anabata ndị na - anabata AT1 maka angiotensin-2, na - egbochi guzobe nke angiotensin-2 site na angiotensin-1, si otú a na - egbochi mmetụta vasoconstrictor nke angiotensin nke ụdị nke abụọ. Ọgwụ na-ebelata ọbara mgbali, na-enweghị emetụta mmetụ obi. A na - eji ya maka ọbara mgbali dị mkpa, yana iji belata ihe egwu nke nkụchi obi na atherothrombotic ụdị ọnya ọgbụgba na ischemic na mmadụ na - ebute ọrịa ndị a, na - enwe ọbara ọbara intracranial iji gbochie spasm nke abụọ nke arịa ụbụrụ, nke na - eduga ná nhụjuanya nke ọnọdụ onye ọrịa. Na-a theụ ọgwụ ahụ otu ugboro n'ụbọchị. Ọ nwere ike ibute allergies, dyspepsia, hypotension, gbasara akụrụ na ọrịa imeju, adịghị ike, dizziness, mgbanwe na usoro ọbara, hyperkalemia, olu mgbu. Contraindicated bụrụ nke anagidee, hypotension, ọrịa nke ọrịa imeju na akụrụ, ụmụaka, ndị ime na ndị na-ete nwa.

Telsartan (mbadamba) → synonym Rating: 17 Up

Ihe analogue dị ọnụ ala site na 14 rubles.

Emeputa: -
Mwepụta Mwepụta:

Mbadamba ụrọ, 40 mg, Nke 30

Ọnụahịa Telsartan na ụlọ ahịa ọgwụ: site na 232 rubles. ruo 556 rub. Onyinye (577)
Telsartan bu okwu ndi India maka telzap. Mwepụta weputara - mbadamba 40 na 80 mg (Nke 30). O bu ihe anabataghi nke ndi anakpo angiotensin-2. A na - eji ya na ndị ọrịa nwere ọbara mgbali elu (dị mkpa), yana ndị mmadụ karịrị afọ 55 bụ ndị nwere nnukwu ihe egwu nke ọrịa obi na atherothrombotic sitere na mgbochi nke mbibi abụọ na --ebi ugboro ugboro na ọrịa ọgbụgbọ na ọnya ọgbụgba, ọnụnọ mgbu azụ, ọrịa ọgụ. nsọtụ ala, belata ọghọm nkwarụ na ịnwụ site na ọrịa ndị a. A na-eji ya eme ihe n'ọtụtụ akwara na akwara ozi maka ịmị mkpụrụ nke ọnya ụbụrụ na-akpata oge na ọnụnọ na ọnya ọgbụgba maka mgbochi nke spasm nke abụọ, nke na-eduga ná nhụjuanya nke ọnọdụ onye ọrịa. Ihe ogwu ahu di na ogwu ya, ma ya na umu aka ya, tinyere onodu ya na hypotension, ya na akuko, ma obu ya na akwara ya, ma o bu enweghi ike imu ya, ma o bu inye ya ara, maka umu aka na umu aka.

Ihe analog dị ọnụ karịa 6 rubles.

A na - emepụta Telmista (okwu maka Telzap) - na Slovenia na mbadamba 40 mg (Nke 28 na 30) na 80 mg (Nke 28). Ihe na-arụ ọrụ bụ telmisartan. Usoro ihe eji eme ya yiri ọgwụ ndị a dị n’elu. A na-ewere otu mbadamba otu ugboro n'ụbọchị maka ogologo oge. A na-eji ha mee ihe na ndị ọrịa nwere ọbara mgbali elu akwara dị mkpa na ndị mmadụ nọ n'ihe egwu dị elu nke ọrịa obi nke mmalite athero-thrombotic sitere (nkụchi obi, ọnya, na-ekpochapụ ọrịa nke arịa nke ala ala) maka mgbochi mbụ ha na nke abụọ, mbelata nkwarụ na ọnwụ na usoro a. A na-eji ya mee ihe n'ebe ndị ọrịa nwere ọria ụbụrụ iji gbochie vasoconstriction nke abụọ na mpaghara a na necrosis nke anụ ụbụrụ gburugburu n'ọbara. Mgbe ị na-a ,ụ ọgwụ, mmeghachi omume nfụkasị ahụ, ụkwara, dịka oria, dyspepsia, hypotension, dizziness, adịghị ike, usoro ọbara, akụrụ na imeju, edema nwere ike ime.

Ihe analog dị ọnụ karịa 227 rubles.

Edarbi - a na-emepụta analogue nke Telzap, na Denmark, Japan, Ireland na USA na mbadamba 40 na 80 mg (Mba. 28). Ihe na-arụ ọrụ bụ azilsartan. Ọ na - egbochi ndị na - anabata angiotensin-2, na - egbochi ọrụ nke usoro renin-angiotensin-aldosterone, nke na - akpata mmetụta antihypertensive. A na - eji ya na ndị ọrịa nwere nnukwu ọbara ọgbụgba (dị ezigbo mkpa), ndị mmadụ nwere nnukwu ihe mberede nke ọrịa obi maka mgbochi ha na nke sekọndrị, yana ibelata ihe ize ndụ nke nkwarụ na ịnwụ site na ọrịa ndị a. A na-eji ya maka ọnya ọgbụgba na ọnya ọbara intracerebral maka mgbochi nke spasm nke arịa ụbụrụ. Nsonaazụ (ọ na-adịkarị nro ma ọ bụ agafeghị oke) nwere ike ịda n’ụdị mmeghachi ahụ nfụkasị, nrịanrịa dyspeptik, dizzness, adịghị ike izugbe, CPK nke ọbara, hypotension, edema n'ụba, ọrụ na-abawanye nke imeju, urea, na transinases creatinine. Ihe mgbochi megide iji ọgwụ ahụ bụ ntachi obi ya, nchịkwa ọnụ ya na aliskiren na ndị na - egbochi ACE na ndị ọrịa nwere ọrịa mellitus, oge nwata na oge uto, ime na lactation.

Ihe analogue dị ọnụ karịa 249 rubles.

Mikardis (okwu a na-akpọ maka Telzap) bụ ọgwụ ndị German mepụtara na mbadamba 40 mg (Nke 14 na 28) na 80 mg (Nke 28). Ọ nwere otu ihe arụ ọrụ dị ka telzap yana usoro arụmọrụ yiri ya. A na-eji ya agwọ ọbara mgbali elu, yana iji belata ihe ọghọm ọrịa obi (dịka ọrịa obi obi ụbụrụ, nnukwu myocardial infarction, atherothrombotic subtype of ischemic stroke, transient ischemic Attack, obere ọrịa akwara akwara, wdg) na ndị mmadụ nwere ike ịbelata ma belata ohere. nkwarụ na ịnwụ site na ọrịa ndị a. A na-ejikwa ya maka ọnya ọgbụgba ọbara, ọbara ọgbụgba na-egbu oge na ọnya ọnya ọgbụgba maka mgbochi nke vasospasm nke abụọ, nke na-eduga n’ịkpụbe mpaghara mpaghara necrosis na mpaghara anya nke ọbara na-eleba anya ma na-ebute mmụba nke akwara ozi na njọ nke ọnọdụ onye ọrịa. Can nweghị ike iji ọgwụ ahụ ya na ntachi obi ya, ihe mgbochi nke biliary tract, ọrịa imeju na akụrụ, ọnya ọgbụgba akwara na-arịa ọrịa ọgbụgba akwara na ndị ọrịa ACE inhibitors na aliskiren, nke nwere mkpụrụ osisi fructose, na ụmụaka na ndị na-eto eto, ụmụ nwanyị dị ime na ndị na-actụ nwa.

Mpempe usoro onunu ogwu

Otu mbadamba ihe

bekee arụ ọrụ: telmisartan 40,000 ma ọ bụ 80,000 mg, karị,

hydrochlorothiazide 12.500 mg ma ọ bụ 25,000 mg, n'otu n'otu,

ndị na-ebu ụzọ: sorbitol, sodium hydroxide, povidone 25, magnesium stearate

Mbadamba mbadamba ụrọ nke nwere biconvex dị n’elu ala site na ọcha ruo odo, nke nwere nọmba “41” n’akụkụ otu mbadamba ahụ, ihe dịka 12 mm n’ogologo na ihe dịka 6 mm sara mbaramaka usoro onunu ogwu 40 mg / 12.5 mg).

Mbadamba ụrọ nke nwere biconvex dị elu nwere agba site na ọcha ruo odo, nke nwere nọmba “81” n'otu akụkụ mbadamba ụrọ ahụ, ihe dịka 16.5 mm n'ogologo, ihe dịka 8.3 mm n'obosara.maka onunu ogwu nke 80 mg / 12.5 mg).

Mbadamba mbadamba ụrọ nke nwere biconvex dị n’elu ọcha ruo na odo, nke nwere “82” n’otu akụkụ mbadamba ihe ahụ, ihe dịka 16 mm n’ogologo, ihe dịka 8 mm sara mbara (maka onunu ogwu nke 80 mg / 25 mg).

Ngwongwo ogwu

Mlọ ọgwụ

Ojiji nke hydrochlorothiazide na telmisartan anaghị emetụta ọgwụ ọgwụ nke ọgwụ ndị a.

Telmisartan: Mgbe nchịkwa ọnụ gasịrị, a na-enweta ọnụ ọgụgụ kachasị elu nke telmisartan mgbe awa 0,5 - 1.5. Nnukwu bioavailability nke telmisartan na dose 40 mg na 160 mg bụ 42% na 58%, otu. Mgbe ị na-ewere telmisartan n'otu oge na nri, mbelata na AUC (mpaghara n'okpuru oge ịta ahụhụ) sitere na 6% (na dose 40 mg) ruo 19% (na dose 160 mg). Mgbe awa 3 a malitesịrị ịbanye n'ọbara plasma ọbara, ọ gụpụrụ nri. Mbelata nke obere na AUC anaghị ebute mbelata nke arụmọrụ ọgwụgwọ. Thelọ ọgwụ ọgwụ ọgwụ telmisartan nke a na-ekwu okwu bụ ihe edoghị anya na ọnụọgụ nke 20-160 mg yana mmụba dị ukwuu n'ọbara plasma (Cmax na AUC) na-abawanye ụba. Onweghi otutu mkpocha egwu telmisartan achoputara.

Hydrochlorothiazide: Mgbe nchịkwa ọnụ nke Telzap Plus, oke nke hydrochlorothiazide eruola ihe dị ka awa 1.0 ruo 3.0 mgbe ị theụsịrị ọgwụ ahụ. Dabere na mkpịsị mkpụrụ mmiri nke hydrochlorothiazide, bioavailability zuru oke bụ ihe dịka 60%.

Telmisartan dabere na protein ndị dị na plasma (karịa 99.5%), ọkachasị nwere albumin na alfa-1-acid glycoprotein. Olu nkesa nkesa bụ ihe ruru 500 L, nke na-egosi ijikọ anụ ahụ ọzọ.

Hydrochlorothiazide Ihe nchebe 68% na protein plasma na olu nke nkesa bụ 0.83 - 1.14 l / n'arọ.

Telmisartan metabolized site na njiko nke acylglucuronide na-arụ ọrụ ọgwụ. Glucuronide nke ogige nne na nna bụ naanị metabolite nke ahụrụla n’ime ụmụ mmadụ. Mgbe otu ọgwụ 14C nke akara telmisartan kpọrọ akara, glucuronide bụ ihe dịka 11% nke redioachibidoro plasma tụọ. Cytochrome P450 na isoenzymes anaghị esonye na metabolism nke telmisartan.

Hydrochlorothiazide adịghị metabolized na mmadụ

Telmisartan: Mgbe ọgwụgwọ intravenous ma ọ bụ nke ọnụ ọgụgụ 14C kpọrọ akara telmisartan, a na-apụtakarị ọtụtụ ọgwụ (> 97%) na feces site na mpụta biliary. A hụrụ obere mpịakọta na mmamịrị.

Mkpokọta plasma nke telmisartan mgbe nchịkwa ọnụ bụ> 1500 ml / min. Nkeji ọkara ndụ bụ> 20 awa.

Hydrochlorothiazide N'ime ihe dị na mmamịrị agbanwebeghị. Ihe dị ka pasent 60 nke ọgwụ a na-apụ apụ n'ime awa 48. Mkpochapu ntaramahụhụ dị ihe dị ka 250 - 300 ml / min. Nkeji ọkara ndụ bụ 10 ka awa iri na ise.

Ndị okenye na-arịa ọrịa

Aclọ ọgwụ ọgwụ telmisartan adịghị iche na ndị agadi na ndị ọrịa na-erubeghị afọ 65.

Ihe plasma nke telmisartan ruru ugboro abụọ n'ime ụmụ nwanyị karịa nke ụmụ nwoke. Na omumu ihe omumu ihe banyere ogwu, enweghi oke mmetuta nke nzaghachi obara ma obu otutu onodu orthostatic n’ime ndi nwanyi. Dose ukpụhọde adịghị. A chọpụtara na ụmụ nwanyị na-enwekarị oghere Plasma nke hydrochlorothiazide karịa ụmụ nwoke. O nweghi ihe di nkpa.

Ọrịa enweghị akụrụ

Rezọ ịgba ụgwọ adịghị emetụta mwepụ telmisartan. Dabere na nsonaazụ nke obere ahụmịhe na Telzap Plus n'ime ndị ọrịa nwere obere mkpụkọ akwara nwa obere (ikike idozi 30-60 ml / min, nkezi nke ihe dị ka 50 ml / min), ndozi dose adịghị mkpa na ndị ọrịa nwere obere ọrụ gbasara ọrụ. A naghị ewepụ Telmisartan n'ọbara site na hemodialysis. N'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa, ọnụego mkpochapu hydrochlorothiazide belatara. N'ime ihe omumu na ndi ọrịa nwere ikike okike okike 90 ml / min, ọkara nke hydrochlorothiazide mụbara. N'ime ndị ọrịa nwere akụrụ na-anaghị arụ ọrụ, iwepu ọkara ndụ bụ ihe dịka 34 awa.

Ndị ọrịa nwere ọrịa imeju

N'ime ndị ọrịa nwere oke ịba ọcha n'anya, bioavailability zuru oke nke telmisartan na-abawanye na 100%. Ndụ ọkara nke imeju anaghị agbanwe agbanwe.

Farmakodinamika

Telzap Plus bụ ngwakọta nke antagonistin II receptor antagonist (ARAII), telmisartan, na thiazide diuretic, hydrochlorothiazide. Nchikota nke ihe ndi a nwere uto antihypertensive, na-wedata obara mgbali elu karie ihe obula mebere ya. Telzap Plus mgbe ewere ya otu ugboro n’ụbọchị na-eduga n'ịbelata ọbara mgbali elu nke ọma.

Telmisartan bụ nti angiotensin II angagonensin II receagonor antagonist (ụdị AT1) maka nchịkwa ọnụ. Telmisartan nwere nnukwu ihe yiri nke a na - achụpụ angiotensin nke II site na saịtị ya na-anabata ndị nabatara ụdị subtype 1 (AT1), bụ ndị na-ahụ maka mmetụta a maara nke angiotensin II. Telmisartan anaghị egosipụta ọrụ agonist ọ bụla na-emegide onye na-anabata AT1. Telmisartan ahọrọ nke ọma na onye na-anabata AT1. Idochi mmadu aru ogologo oge. Telmisartan egosighi ịdị ka ibe ya maka ndị nnabata ndị ọzọ, gụnyere ndị nnabata AT2 na ndị ọzọ, ndị na-anabataghị ndị na-anabata AT.

Amamịghe ọrụ nke ndị nnabata ndị a, yana nsonaazụ nke ike ha nwere na angiotensin nke abụọ, amụchaghị nke na-abawanye na nhọpụta nke telmisartan.

Telmisartan na-ebelata ọkwa Plasma aldosterone, anaghị egbochi renin na plasma na ion nke mmadụ.

Telmisartan anaghị egbochi enzyme angiotensin na-agbanwe agbanwe (kinase II), nke na-ebelata mmepụta bradykinin. Yabụ, enweghị nkwanye ugwu nke mmetụta ọ bụla metụtara ihe bradykinin.

Mkpụrụ 80 mg nke telmisartan, nke enyere ndị ọrụ afọ ofufo ahụike ahụ ike, ihe fọrọ nke nta ka ọ bụrụ na ọ na-egbochi mmụba nke nrụgide sitere na ikpughe na angiotensin II. Mmetụta inhibitory na-adịgide karịa 24 awa (ruo awa 48).

Mgbe ị takingụsịrị ọgwụ mbụ nke telmisartan, ọbara mgbali na-ebelata mgbe awa 3 gachara. Mbelata kachasị na mgbali ọbara, dịka iwu, a na-enweta izu 4-8 mgbe mmalite ọgwụgwọ wee dịgide maka ọgwụgwọ ogologo oge.

Mmetụta antihypertensive na-ewe awa 24 mgbe ị theụsịrị ọgwụ ahụ, gụnyere 4 awa tupu ị doseụ ọgwụ ọzọ, nke nkwenye ọbara na-enyocha ya, yana ọgwụ kwụsiri ike (karịa 80%) nke kacha nta na oke nke ọgwụ ahụ mgbe ịghasịrị 40 na 80 mg nke telmisartan na placebo-achịkwa. omumu akwukwo.

N'ime ndị ọrịa nwere ọbara mgbali elu, telmisartan na-ebelata ma mgbagha ọbara systolic na diastolic na-enweghị na-emetụta ọnụego obi. Antidị arụmọrụ antimispertensive nke telmisartan bụ ihe yiri ndị nnọchianya nke klas ndị ọzọ nke antihypertensive (dị ka egosiri na ọmụmụ ụlọ ọgwụ na-atụnyere telmisartan na amlodipine, atenolol, enalapril, hydrochlorothiazide, na lisinopril).

N'ime nnwale ihu abụọ gbara okpukpu abụọ, ọgwụ a na-achịkwa (N = 687 ndị ọrịa na-enyocha maka arụmọrụ), ndị mmadụ anabataghị mgbakwunye 80 mg / 12.5 mg gosipụtara mmetụta nwayọ nke iweda ọbara mgbali elu nke njikọ 80 mg / 25 mg ma e jiri ya tụnyere ọgwụgwọ ogologo oge na dose 80 mg / 12.5 mg 2.7 / 1,6 mmHg (SBP / DBP) (ọdịiche na mgbanwe mgbanwe agbadoro agbakwunyere na ntọala otu). N'ime ọmụmụ ya na ngwakọta 80 mg / 25 mg, ọbara mgbada belatara, na-ebute mbelata ihe dịka 11.5 / 9.9 mmHg. (GARDEN / DBP).

Nnyocha zuru oke nke izu abụọ yiri nke 8 kpuru ìsì abụọ, ọnwụnwa a na-ejikwa ọgwụ na-atụnyere valsartan / hydrochlorothiazide 160 mg / 25 mg (N = 2121 ndị ọrịa nyochachara maka arụmọrụ) gosipụtara mmetụta ka ukwuu nke wedata ọbara mgbali elu 2.2 / 1.2 mm Hg . (SBP / DBP) (ihe dị iche na mgbanwe pụtara mgbanwe site na ntanetị, otu dị iche iche) iji kwado nchikota nke telmisartan / hydrochlorothiazide 80 mg / 25 mg.

Mgbe etinyere ọgwụgwọ nke ọma na telmisartan, ọbara mgbali ji nwayọọ nwayọọ laghachi uru mbụ ya n'ime ọtụtụ ụbọchị na-enweghị ihe ịrịba ama nke ọbara mgbali elu.

N'ime nyocha ụlọ ọgwụ na-atụnyere ọgwụgwọ abụọ ahụ, ọnọdụ ụkwara dị ala belatara nke ukwuu na ndị ọrịa na-anata telmisartan karịa ndị na-anata enzyme enzyme enzyme.

Ihe omumu ihe omumu nke PRoFESS mere na ndi oria karia iri-ise n’enweghi oria gosiputara na-abawanye sepsis na telmisartan ma e jiri ya tụnyere placebo, 0.70% ma e jiri ya tụnyere 0.49% MA 1.43 (nkeji oge ntụkwasị obi 95% na 1.00 - 2.06), ugboro ole ọnwụ sitere na sepsis dị elu na ndị ọrịa na-ewere telmisartan (0.33%) ma e jiri ya tụnyere ndị ọrịa na-ewere placebo (0.16%) MA 2.07 (95% nkeji oge ntụkwasị obi 1.14 - 3.76). Mmụba a chọpụtara na oghere nke metụtara sistemu nke telmisartan nwere ike ịbụ ihe efu ma ọ bụ nwere ike jikọtara ya na usoro a na-amaghị ugbu a.

Amaghi ihe nsogbu nke telmisartan na onwu na akwara. Hydrochlorothiazide bụ thiazide diuretic. Amaghị usoro nke antihypertensive mmetụta nke thiazide diuretics. Thiazides na-emetụta usoro sistemụ nke reabsorption nke electrolytes na tubules, na-abawanye mkpirisi nke sodium na chloride na mkpokọ nha. Mmetụta diuretic nke hydrochlorothiazide na-ebelata oke olu nke plasma, na-eme ka ọrụ plasma renin dịkwuo elu, na-eme ka mkpụrụ ndụ nke aldosterone na-esochi, mmụba na potassium na mmamịrị, mfu nke bicarbonate na mbelata na protein nke serum. Achọpụtara site na mgbochi nke sistemụ renin-angiotensin-aldosterone, njikwa nke telmisartan, dịka iwu, na-egbochi mfu nke potassium metụtara diuretics ndị a. Mgbe ị na-eji hydrochlorothiazide, mmalite nke diuresis na-apụta mgbe elekere abụọ gachara, mmetụta kachasị elu na-apụta mgbe ihe dị ka awa anọ gasịrị, ebe mmetụta ahụ na-adịgide ruo ihe dịka awa 6-12.

Ọmụmụ Epidemiological egosila na ọgwụgwọ ogologo oge na hydrochlorothiazide na-ebelata ihe ize ndụ nke ọnwụ obi na ọrịa.

Usoro onunu ogwu na nhazi

Mbadamba Telzap Plus bụ maka iji ọnụ mee ihe, n'agbanyeghị nri a na-eri, a na-ewere ya otu ugboro n’ụbọchị ma ekwesịrị iji mmiri saa ya.

Edebere Telzap Plus maka ndị ọrịa na-ejighị ike zuru oke na telmisartan monotherapy. A na-atụ aro inye mkpụrụedemede ọ bụla nke ihe abụọ meghere tupu ịgbanye na ngwakọta ọ bụla edobere. Na nnabata nke ụlọ ọgwụ, enwere ike ịtụle ntụgharị aka site na monotherapy rue na njikọta ofu.

Enwere ike ịgwọ Telzap Plus 40 mg / 12.5 mg otu ugboro kwa ụbọchị maka ndị ọrịa na-ejideghị ikike 40 mg telmisartan monotherapy nke ọma.

Enwere ike ịgwọ Telzap Plus 80 mg / 12.5 mg otu ugboro kwa ụbọchị maka ndị ọrịa ọbara ọbara na-achịkwaghị ike site na telmisartan monotherapy 80 mg.

Enwere ike ịgwọta Telzap Plus 80 mg / 25 mg otu ugboro kwa ụbọchị maka ndị ọrịa na-achịkwa ọbara mgbali nke ọma mgbe ị na-etinye Telzap Plus 80 / 12.5 mg ma ọ bụ na ndị ọrịa ọbara mgbali elu ha nwere mbụ na telmisartan na hydrochlorothiazide iche.

Jiri na ndị agadi

Dose ukpụhọde adịghị.

Ọrịa enweghị akụrụ

A na-atụ aro maka oge akụrụngwa maka ọrụ akụrụ (lee “Ntuziaka Pụrụ Iche”)

Ndị ọrịa nwere ọrịa imeju

N'ime ndị ọrịa nwere ọrịa ịba ọcha ọwụwa ruo obere ruo oge, usoro onunu ogwu ekwesịghị gafere Telzap Plus 40 mg / 12.5 mg otu ugboro n'ụbọchị. Achọpụtaghị Telzap Plus maka ndị ọrịa nwere nnukwu ọrụ imeju. Ekwesịrị iji Thiazides jiri nlezianya mee ihe na ndị ọrịa nwere ọrụ imeju na-arụ ọrụ (lee akụkụ "ntuziaka pụrụ iche").

Emebebeghị nchekwa na arụmọrụ nke Telzap Plus na ụmụaka na ndị nọ n'afọ iri na asatọ. Data adịghị.

Na arụ ọrụ ezumike ọrụ

Ojiji nke Telzap bụ contraindicated na ndị ọrịa nwere akụrụ akwara (GFR erughị 60 ml / min / 1.73 m 2) ndị na-eji ọgwụ ahụ emekọ ihe ọnụ na aliskiren.

N'iji nlezianya mee, a ga-edobe Telzap maka ọrụ akụrụ nwere nsogbu, akwara akwara stenosis akwara akwara, arter stenosis nke naanị akụrụ na-arụ ọrụ.

Na mmebi akwara siri ike na ndị ọrịa ịba n'ọrịa ka a na-atụ aro ka ha jiri ọgwụ izizi nke ụbọchị ọ bụla erughi 20 mg.

Maka ịrụ ọrụ ahazi oruru na-agbanwe agbanwe, ọchọghị usoro iji gbanwee ya.

Ọbara Mgbali Dị Mkpa

N'ime ndị ọrịa, telmisartan na ọgwụ nke 80 mg kpamkpam egbochi mmetụta ọbara mgbali nke angiotensin II. A na-ahụ mmalite mmalite nke ọgụ ọgwụ mgbochi n'ime awa 3 mgbe nchịkwa izizi nke telmisartan. Mmetụta nke ọgwụ ahụ na-adịgide ruo awa 24 ma na-adị ọrịka dị ka awa 48. Mmetụta antihypertensive na-ebikarị izu anọ 4-8 mgbe ị regularụsịrị ya.

N'ime ndị ọrịa nwere ọbara mgbali elu, telmisartan lowers systolic na ọbara mgbali ọbara (BP) na-enweghị emetụta mmetụ obi (HR).

N'ihe banyere njiri siri ike nke telmisartan, ọbara mgbali ji nwayọọ nwayọọ na-alaghachikwa n'ọkwa mbụ ya karịa ọtụtụ ụbọchị na-enweghị mmepe nke ọrịa "ndọrọpụ".

Dika nsonaazụ nke ihe omumu ihe omumu gosiputara, mmetụta antihypertensive nke telmisartan nwere ike imetụta mmetụta antihypertensive nke ọgwụ nke klas ndị ọzọ (amlodipine, atenolol, enalapril, hydrochlorothiazide na lisinopril).

Ọnụnọ nke okpukpu okpukpu dara nke ukwu na telmisartan ma e jiri ya tụnyere ndị na-egbochi ACE.

Mgbochi Ọrịa Obi

Ndị ọrịa dị afọ iri ise ma ọ bụ karịa nwere ọrịa obi, ọrịa strok, ọrịa ọnụnọ, ọrịa ọgụ, ma ọ bụ nsogbu nke ọrịa shuga 2 (dịka ọmụmaatụ, retinopathy, hypertrophy ekpe, macro- ma ọ bụ microalbuminuria) na akụkọ ihe mere eme nke ihe egwu obi. emume-egwu, telmisartan nwere mmetụta yiri nke ramipril n'ibelata njedebe ejikọtara ọnụ: mkpụrụ ndụ akwara sitere na infarction myocardial na-enweghị nsonaazụ na-egbu egbu, ọrịa strok. enweghị ọnwụ ma ọ bụ ụlọ ọgwụ n'ihi na-adịghị ala ala obi ọdịda.

Telmisartan rụpụtara ọrụ dị ka ramipril n'ibelata ugboro ole isi ihe: ọnwụ obi, infarction myocardial na-adịghị egbu egbu. A naghị akọwakarị ọkọchị akpịrị na angioedema na telmisartan ma e jiri ya tụnyere ramipril, ebe hypotension arterial na-adịkarịkarị na telmisartan.

Egwu

Mgbe etinyere ya, a na-etinye telmisartan ngwa ngwa site na eriri afọ. Bioavailability bụ 50%. Mgbe ewere nri n'otu oge, mbelata na AUC (mpaghara dị n'okpuru usoro ịta ahụhụ) sitere na 6% (na dose 40 mg) ruo 19% (na dose 160 mg). Mgbe awa 3 gachara nlekọta ahụ, a na-etinye uche ịta ahụ na plasma ọbara n’onweghị onwe, a na-ewere telmisartan n’otu oge ahụ ka nri ma ọ bụ. Enwere ọdịiche na mkpokọta plasma na ụmụ nwoke na ụmụ nwanyị. Stach (ntinye kachasị) na AUC dị ihe dịka ugboro atọ na ugboro abụọ, otu n'otu, ọ kachasị elu na ụmụ nwanyị ma e jiri ya tụnyere ụmụ nwoke na-enweghị nnukwu mmetụta na arụmọrụ.

Enweghị mmekọrịta kwụ ọtọ n'etiti ị theụ ọgwụ ahụ yana ịta ụbara plasma ya. Stach na, ruo ntakịrị dị nta, AUC na-abawanye nke ukwuu na ịba ụba dose ahụ mgbe ị na-eji ọgwụ dị elu karịa 40 mg kwa ụbọchị.

Metabolism

A na-agagharị ya site na conjugation na glucuronic acid. Na conjugate enweghị ọrụ ọgwụ.

Ọkara ndụ (T. / 2) karịrị awa 20. Ọ gafere site na eriri afọ na - agbanweghi, site na akụrụ ya - erughi 1%. Nchịkọta zuru oke nke plasma dị elu (ihe dị ka 1000 ml / min) ma e jiri ya tụnyere ọbara ọbara "ọria" (ihe dị ka 1500 ml / min).

Jiri nlezianya

Ekwesịrị iji ọgwụ ndị Telzap dezie ya na ọnọdụ ndị a:

Stenosis abụọ akụrụngwa akwara ma ọ bụ stenosis nke otu akụrụ na-arụ ọrụ,
ọrụ ezughi oke,
obere ịba ọcha n'anya.
mbelata n'ọbara ọbara (BCC) megide nrịgo iribiga nri nke gara aga, mgbochi nke sodium chloride, afọ ọsịsa ma ọ bụ vomiting,
hyponatremia,
hyperkalemia
Ọnọdụ mgbe akụrụgharị akụrụ (enweghị ahụmịhe iji ya),
obi ike ọgwụgwụ,
stenosis nke aortic na valvụ valve,
ike obara nke obara,
isi hyperaldosteronism (oru adighi na nchekwa guzobere)

Ọbara ọbara

Ọgwụ mbụ a tụrụ aro Telzap bụ 1 mbadamba (40 mg) otu ugboro n'ụbọchị. N'ime ụfọdụ ndị ọrịa, 20 mg kwa ụbọchị nwere ike ịdị irè. Enwere ike inweta 20 mg site na ịkekọrịta mbadamba 40 mg na ọkara n'ihe ize ndụ. N'ọnọdụ ebe enweghị ọgwụgwọ ọgwụgwọ, enwere ike ịba ụba dose a tụrụ aro nke Telzap ruo 80 mg otu ugboro n'ụbọchị.

Dika ozo, enwere ike iburu Telzap yana aru oyuzu nke thiazide, dika imaatu hydrochlorothiazide, nke, mgbe ejikọtara ya, nwere ihe mmetuta ozo. Mgbe ị na-ekpebi ma ịbawanye ọgwụ ahụ, ekwesịrị iburu n'uche na mmetụta antihypertensive kachasị na-arụkarị n'ime izu 4-8 mgbe mmalite nke ọgwụgwọ.

Ndị ọrịa nwere ọrụ mgbazinye nsogbu

Ahụmịhe na telmisartan na ndị ọrịa nwere nnukwu akụrụ okpu ma ọ bụ ndị ọrịa na-agwọ ọrịa metụtara akwara dị oke. A na-atụ aro ka ndị ọrịa a obere mbido ọgwụ nke 20 mg kwa ụbọchị (lee mpaghara "Nlekọta pụrụ iche"). Maka ndị ọrịa nwere nnukwu ọrụ mkpado na-adịghị ala ala, a naghị achọ ndozi ya.

Ikwe ntinye ọnụ nke Telzap na aliskiren bụ contraindicated na ndị ọrịa nwere ọdịda akụrụ.

Inwe oge eji eme Telzap ya na ndị na - egbochi ACE na ndị ọrịa nwere ọrịa nephropathy.

Ndị ọrịa nwere ọria imeju

A na-eke Telzap na ndị ọrịa nwere nnukwu ahụ ọria ya ịba ọcha n'anya (klas C dịka nhazi nke nwatakịrị). N'ime ndị ọrịa nwere obere ịba ọcha n'anya ruo na obere (klaasị A na B dị ka nhazi ụmụaka-Pugh, dị iche iche), a na-eji ọgwụ akpachara anya iji ọgwụ ahụ, ọnụọgụ ekwesịghị ịfe 40 mg otu ugboro n'ụbọchị.

Ime

Ugbu a, ozi a pụrụ ịdabere na nchekwa nke telmisartan na ụmụ nwanyị dị ime adịghị. N'ime ọmụmụ anụmanụ, achọpụtawo nsị na ọgwụ ọjọọ nke ọgwụ. Ihe eji eme Telzap contraindicated n'oge ime (lee mpaghara “Contraindications”).

Ọ bụrụ na ọ dị mkpa ịgwọ ọrịa ogologo oge na Telzap, ndị ọrịa na-eme atụmatụ ịtụrụ ime kwesịrị ịhọrọ ọgwụ mgbochi ọgwụ ọzọ na profaịlụ nchekwa enwetara maka iji n'oge afọ ime. Mgbe emechara eziokwu banyere afọ ime, a ga-akwụsị ọgwụgwọ na Telzap ozugbo, ma ọ bụrụ na ọ dị mkpa, ekwesịrị ịmalite usoro ọgwụgwọ ọzọ.

Dị ka nsonaazụ nke nyocha ụlọ ọgwụ gosipụtara, ojiji nke ARAP n'oge ọnwa nke abụọ na nke atọ nke afọ ime nwere mmetụta na-egbu egbu na nwa ebu n'afọ (ọrụ ezigharị nke arụ ọrụ, oligohydramnios, igbu oge okpokoro isi) na nwa amụrụ ọhụrụ (ọdịda akụrụ, ọdịda hypotension na hyperkalemia). Mgbe ị na-eji ARAN n’oge ọnwa nke abụọ nke ịtụrụ ime, a na-atụ aro inyocha ultrasound nke akụrụ na okpokoro isi nke nwa ebu n’afọ.

Shouldmụaka ndị nne ha buru ọgwụ ARAP n'oge afọ ime kwesịrị ka ejiri nlezianya nyochaa ha niile.

Oge ara

Ihe omuma banyere ojiji nke telmisartan n'oge inye umu ara adighi adi. Telnara Telzap n'oge inye ara ara, a ga-eji usoro ọgwụ mgbochi ọzọ nke nwere ezigbo nchekwa nchekwa, ọkachasị mgbe ị na-enye nwa amụrụ ọhụrụ ma ọ bụ amụtaghị nwa.

Mmetụta akụkụ

N'oge ị Orụ ọgwụ Ordiss, mmetụta ndị ọzọ ga-ekwe omume:

Ọrịa na-efe efe na nje: na - adịghị ala ala - ọrịa urinary tract, gụnyere cystitis, ọrịa akụkụ okuku ume na elu, gụnyere pharyngitis na sinusitis, adịkarịghị - sepsis.
Site na sistemụ hemopoietic: nwa oge - anaemia, adịkarịghị - eosinophilia, thrombocytopenia.
Site na usoro ahụ ji alụso ọrịa ọgụ: adịkarịghị - mmeghachi omume anaphylactic, hypersensitivity.
Site n'akụkụ nke metabolism: ugboro ugboro - hyperkalemia, adịkarịghị - hypoglycemia (na ndị ọrịa nwere ọrịa mellitus).
Nsogbu uche: n ’enweghị oge - ehighi ura, ịda mba, na - adịkarịghị - ụjọ.
Site na sistem ụjọ: nwa oge - ada mba, obere oge - ụra ụra.
Site n'akụkụ akụkụ ahụ nke ọhụụ: a na - adịghị ahụkebe - mgbarụ anya.
N'akụkụ akụkụ nke ntị ịnụ na nsogbu labyrinth: ugboro ugboro - vertigo.
Site na usoro obi: ugboro ugboro - bradycardia, mbelata ọbara mgbali elu, orthostatic hypotension, adịkarịghị - tachycardia.
Site na usoro iku ume: obere oge - ume iku ume, ụkwara, adịkarịsịrị - ọrịa ngụgụ.
Site na eriri afọ: ugboro ugboro - mgbu afọ, afọ ọsịsa, dyspepsia, flatulence, vomiting, adịkarịghị - akpọnwụ akpịrị, ahụ erughị ala na afo, imebi ihe ụtọ.
Site na imeju na traktị nke biliary: adịkarịghị - arụ ọrụ imeju / mmebi imeju.
N’akụkụ anụ ahụ na akwara dị n’okpuru: n’oge na - adịghị mma - itching skin, hyperhidrosis, friji akpụkpọ, adịkarịghị - angioedema (yana egbu egbu), eczema, erythema, urticaria, fashfish ọgwụ, ihe nfụkasị anụ ahụ.
Site na usoro akwara: n'adịghị ala - mgbu azụ (sciatica), olu mgbu, myalgia, adịkarịghị - arthralgia, ihe mgbu na aka, ihe mgbu na akwara (ihe mgbawara dịka akwara).
Site na sistemụ urinary: ọrụ obere ọrụ na-arụ ọrụ akwara, gụnyere nnukwu akụrụ gbasara akụrụ.
Na mpaghara nyocha na akụrụngwa: ugboro ugboro - mmụba na mkpokọta nke creatinine na plasma ọbara, adịkarịghị - mbelata ọdịnaya nke hemoglobin, mmụba nke ọdịnaya uric acid na plasma ọbara, mmụba na ọrụ nke enzymes imeju na CPK.
Ndị ọzọ: oge na - adịghị ala ala, mgbu obi, asthenia, adịkarịghị - ọrịa na-efe efe.

Mkparịta ụka ọgwụ ọjọọ

Site n'iji telmisartan na digoxin, n'otu oge, ịrị elu na Cmax nke digoxin na plasma ọbara site na 49% na Cmin site na 20%. Na nmalite ọgwụgwọ, mgbe ị na-ahọrọ otu ọgwụ na ịkwụsị ọgwụgwọ na telmisartan, a ga-elezi anya itinye uche nke digoxin na plasma ọbara iji kwado ya n'ime usoro ọgwụgwọ ahụ.

Ihe mgbochi abụọ nke RAAS

Oge telmisartan na aliskiren ma ọ bụ ọgwụ nwere aliskiren bụ contraindicated na ndị ọrịa na-arịa ọrịa shuga mellitus na / ma ọ bụ agafeghị oke na nnukwu akụrụ odida (GFR erughị 60 ml / min / 1.73 m2 nke akụkụ elu ahụ) na akwadoghị ndị ọrịa ndị ọzọ.

A na - egbochi contraindial iji telmisartan na ACE inhibitors na ndị ọrịa nwere ọrịa nephropathy na - akwadoghị maka ndị ọrịa ndị ọzọ.

Omumu ihe omumu gosiputara na okpukpu abuo nke RAAS site na iji oru ACE inhibitors, angiotensin II antagonor antagonist, ma obu aliskiren nwere otutu ihe nke ihe ojoo dika akwara hypotension, hyperkalemia, na oru mkpuru akuko (tinyere akuko gbasara akwara). ọgwụ na-eme ọgwụ na RAAS.

Hyperkalemia

Ihe ọghọm nke ịba hyperkalemia nwere ike ịbawanye elu mgbe ejiri ọgwụ ndị ọzọ nwere ike ime ka hyperkalemia (mgbakwunye nri nri na mgbakwunye nnu nke nwere potassium, spredinolactone, eplerenone, triamterene ma ọ bụ amiloride), NSAIDs (gụnyere nhọrọ COX-2 inhibitors) , heparin, immunosuppressants (cyclosporine ma ọ bụ tacrolimus) na trimethoprim).

Ọnọdụ nke hyperkalemia sitere na ihe ndị dị n'ihe ize ndụ metụtara. Ọba ka a na-abawanye mgbe ị na - eji mkpokọ ndị dị n’elu, ọ kachasị elu mgbe ejiri ya mee ihe n’otu oge na -echekarị ọgwụ potassium na nnu nnu nwere potassium. Ojiji telmisartan na ACE inhibitors ma ọ bụ NSAID nwere ihe ọghọm ma ọ bụrụ na-akpachapụ anya.

Ọrụ imeju na-arụ ọrụ

Ojiji nke Telzap bụ contraindicated na ndị ọrịa nwere cholestasis, mgbochi nke biliary ma ọ bụ ọrụ imeju na-arụ ọrụ nke ọma (Child-Pugh klas C), ebe ọ bụ na telmisartan kachasị na bile. Ekwenyere na n'ime ndị ọrịa dị otú a, a na-ebelata mkpochapu hepatic nke telmisartan. N'ime ndị ọrịa nwere ogo imeju dị nwayọ ma ọ bụ na-agafe agafe (klas A na B dabere na nhazi nke Child-Pugh), ekwesịrị iji nlezianya mee ihe Telzap.

Mbelata ọbara dị ala (BCC)

Sympotomatic artpot hypotension, ọkachasị mgbe nchịkwa izizi mbụ gasịrị, nwere ike ịdakwasị ndị ọrịa nwere BCC dị ala na / ma ọ bụ sodium na plasma ọbara na-emegide usoro ọgwụgwọ gara aga yana mmachi, mmachi na iri nnu, afọ ọsịsa ma ọ bụ vomiting.

Ọnọdụ ndị yiri ya (mmiri na / ma ọ bụ ụkọ sodium) kwesịrị iwepụ tupu iwere Telzap.

Ọnọdụ ndị ọzọ metụtara mkpali nke RAAS

N'ime ndị ọrịa olu vaskụla olu na akụrụ ọrụ ya dabere na ọrụ RAAS (dịka ọmụmaatụ, ndị ọrịa nwere ọrịa obi na-adịghị ala ala ma ọ bụ ọrịa akụrụ, gụnyere ọrịa akwara ma ọ bụ stenosis nke otu akụrụ), iji ọgwụ na-emetụta usoro a, enwere ike ijikọ ya na mmepe nke hypotension hypotension, hyperazotemia, oliguria, na n'ọnọdụ ndị obere, nnukwu ọdịda akwara.

Na arụ ọrụ imeju

Nkwekọ nke Telzap maka ịgwọ ndị ọrịa nwere oke ịba ọcha n'anya (klas C dị ka nhazi nke nwatakịrị).

N'iji nlezianya mee, ekwesịrị iji mbadamba ụrọ na nwayọ nwayọ nwayọ gbadaa na-aga (obere klas ụmụaka A na B). Bọchị kwa ụbọchị nke telmisartan ekwesịghị gafere 40 mg.

Mmetụta ikike ịkwọ ụgbọala

Eduzi omumu ihe omumu nke puru iche iji hu ihe ogwu riri na ike inya ugboala. Mgbe ị na-anya ma na-arụ ọrụ n'ụba ndị chọrọ nlebara anya nlebara anya, ekwesịrị ịkpachara anya, ebe ọ bụ na ure na ura nwere ike ọ gaghị adịkarị site na iji Telzap.