Ntuziaka tricor maka ojiji, contraindications, nsonaazụ akụkụ, nyocha

Onye na - ahụ maka hypolipPs sitere na njirisi nke fibroic acid.
Nkwadebe: TRICOR
Ọrụ umi nke ogwu: fenofibrate
Ihe ntinye ATX: C10AB05
KFG: Ọgwụ hypolip Ebola
Nọmba ndebanye: LSR-002450/08
Registrationbọchị ndebanye: 04/03/08
Ndi nwe reg. doc.: Laboratoires FOURNIER S.A.

Ntọhapụ ewepụtara Tricor, nchịkọta ọgwụ na ihe mejupụtara.

A na-eji mbadamba ụrọ na-acha ọcha kpuchie mbadamba ihe ndị ahụ, na ihe odide ahụ bụ "145" n'otu akụkụ yana akara ụlọ ọrụ na nke ọzọ. Mbadamba ihe mkpuchi fim 1 tab. fenofibrate (micronized) 145 mg
Ndị ọkachamara: sucrose, sodium lauryl sulfate, lactose monohydrate, crospovidone, microcrystalline cellulose, colloidal silicon dioxide, hypromellose, sodium docusate, magnesium stearate.
Ihe mejupụtara Shell: Opadry OY-B-28920 (mmanya polyvinyl, titanium dioxide, talc, soy lecithin, xanthan gum).
10 PC. - blisters (1) - ngwugwu nke kaadiboodu.
10 PC. - blisters (2) - ngwugwu nke kaadiboodu.
10 PC. - blisters (3) - ngwugwu nke kaadiboodu.
10 PC. - blisters (5) - ngwugwu nke kaadiboodu.
10 PC. - blisters (9) - ngwugwu nke kaadiboodu.
10 PC. - blisters (10) - ngwugwu nke kaadiboodu.
14 pi. - blisters (2) - ngwugwu nke kaadiboodu.
14 pi. - blisters (6) - ngwugwu nke kaadiboodu.
14 pi. - blisters (7) - ngwugwu nke kaadiboodu.
10 PC. - blisters (28) - igbe kaadiboodu (ichota ulo ogwu).
10 PC. - blisters (30) - igbe kaadiboodu (ichota ulo ogwu).
Nkọwa ọgwụ a sitere na ntuziaka masịrị iwu maka iji ya eme ihe.

Ngwa ogwu ọgwụ Tricor

Onye na - ahụ maka hypolipPs sitere na njirisi nke fibroic acid. Fenofibrate nwere ikike ịgbanwe ihe dị n'ime ahụ mmadụ site na mmụba nke ndị na-anabata PPAR- (ndị na-anabata ndị na-eme ihe na-akpali akpali nke peroxisome proliferator).
Fenofibrate na-eme ka lipolysis plasma na mwepụ nke atherogenic lipoproteins nwee nnukwu ọdịnaya nke triglycerides site na ịgbalite ndị na-anabata PPAR-,, lipoprotein lipase ma belata njikọta nke apoprotein C-III. Mmetụta ndị akọwapụtara n’elu na-eduga na mbelata ọdịnaya nke mkpokọta LDL na VLDL, nke gụnyere apoprotein B (apo B), yana mmụba nke ọdịnaya HDL, nke gụnyere apo A-I na apo A-II. Na mgbakwunye, n'ihi mgbazi nke mmebi nke njikọta na catabolism nke VLDL, fenofibrate na-eme ka mmụpụ nke LDL belata ma belata ọdịnaya nke obere LDL (mmụba na LDL ndị a nwere ọrịa anherogenic lipid phenotype ma jikọtara ya na nnukwu ihe ize ndụ nke CHD).
N'oge ọmụmụ gbasara ọgwụgwọ, achọpụtara na iji fenofibrate belata ọkwa nke cholesterol ngụkọta site na 20-25% na triglycerides site na 40-55% na mmụba nke ọkwa HDL-C site na 10-30%. N’ime ndị ọrịa nwere hypercholesterolemia, ebe eji ewelata ọkwa Chs-LDL site na 20-35%, ojiji nke fenofibrate butere mbelata nke oke: mkpokọta Chs / Chs-HDL, Chs-LDL / Chs-HDL na apo B / apo A-I, nke bụ ihe nrịbama nke atherogenic ihe egwu.
Ideringtụle nsonaazụ fenofibrate na ọkwa nke LDL-C na triglycerides, iji ọgwụ ahụ arụ ọrụ bara uru na ndị ọrịa nwere hypercholesterolemia, ha abụọ na-esoghị na hypertriglyceridemia, gụnyere hyperlipoproteinemia nke abụọ, dịka ọmụmaatụ, na ụdị ọrịa mellitus nke 2. nkwụnye ego Xc (tendon na tubeantant). N'ime ndị ọrịa nwere fibrinogen dị elu nke a na-emeso fenofibrate, a chọpụtara mbelata dị ukwuu na ihe ngosi a, yana ndị ọrịa nwere oke lipoproteins. Na ọgwụgwọ fenofibrate, a na-achọpụta mbelata nke protein C-reactive na akara ndị ọzọ nke mbufụt.
Maka ndị ọrịa nwere dyslipidemia na hyperuricemia, uru ọzọ bụ na fenofibrate nwere mmetụta uricosuric, nke na-eduga n'ịbelata uric acid n'ihe dị ka 25%.
N'ime ọmụmụ ụlọ ọgwụ na nyocha anụmanụ, egosipụtara fenofibrate iji belata nchịkọta platelet nke adenosine diphosphate, arachidonic acid, na epinephrine.

Pharmacokinetics nke ọgwụ.

Egwu
Site na nchịkwa ọnụ nke Tricor, a na-enweta ọgwụ mgabia 145 nke Cmax mgbe awa 2-4 gachara Cmax na plasma na ngụkọta nke micronized fenofibrate n'ụdị nanoparticles (Tricor 145 mg) nwere onwe ya na nri oriri (ya mere, enwere ike ị drugụ ọgwụ ahụ n'oge ọ bụla, n'agbanyeghị nri nri. )
Nkesa
Fenofibroic acid siri ike na ihe karịrị 99% dị na plasma albumin. T1 / 2 - ihe dị ka awa 20. Ọgwụ anaghị agbakọta mgbe otu ọgwụ na iji ogologo oge.
Metabolism
Mgbe nchịkwa ọnụ gachara, mmiri ọgwụ fenfibrate na-enweta mmiri ngwa ngwa site na esterases. Naanị metabolite dị ike nke fenofibrate, fenofibroic acid, dị na plasma. Site n'iji ogologo oge, mkpocha fenofibroic acid dị na plasma na-adịgide, n'agbanyeghị àgwà onye ọrịa ahụ nwere. Fenofibrate abụghị mkpụrụ maka CYP3A4, anaghị etinye aka na metabolism metabolism.
Ojiji
Emere ya ka ọ dị ka mmamịrị n'ụdị fenofibroic acid na glucuronide conjugate. N'ime ụbọchị isii, a na-ewepụ fenofibrate kpamkpam.

Ozi izugbe, ihe mejupụtara na ụdị ịtọhapụ

Dabere na radar, Tricor bụ ọgwụ na - agbada egbugbere ọnụ - si na cholesterol n'ime ọbara. Ojiji ya na-enyere aka belata oke abụba n’ahụ ma na-egbochi imepụta atherosclerosis.

A na-eme ntọhapụ ya na France, ebe a na-ere ọgwụ a n'ụdị mbadamba. Mmetụta nke ọgwụ ahụ bụ n'ihi akụrụngwa bụ isi, nke bụ fenofibrate.

Can nwere ike iji ya naanị nke dọkịta nyere gị, ebe ọ nwere mmetụta siri ike n'ahụ ahụ. O nwere ike ịdị njọ ma ọ bụrụ na erechaghị ya. Ya mere, enwere ike ịzụta ya naanị site na ndenye ọgwụ.

A na-emepụta ego iji na mbadamba. Ihe kachasị dị mkpa nke ọgwụ ahụ bụ fenofibrate. A gunyere ya na mbadamba ihe dika iri aro 145.

Na mgbakwunye na ya, enwere ihe ndị dịka:

emecha
hypromellose,
sodium docusate,
stereị magnesium,
microcrystalline cellulose,
lactose monohydrate,
sodium laurisulfate,
silloon dioxide colloidal.

Ihe ndị a na-enye gị ohere inye ọgwụ ahụ ụdị achọrọ. Mbadamba ụrọ bụ ihe mkpuchi (bp).

Enwekwara mbadamba nkume nke nwere ihe mejuputara ihe ntinye aka nke 160 mg. Ha nwere otu ihe ozo ndi ozo nke ogwu a.

Nchịkọta ọgwụ nwere nhazi dị iche iche. Ha nwere ike tinye site na mbadamba 10 ruo 300 (usoro nke 145 mg) ma ọ bụ site na 10 ruo 100 iberibe (dose nke 160 mg).

Emere ọgwụ ọgwụ na ọgwụ ọgwụ

Iji ghọta ihe achọrọ ọgwụ a, ịkwesiri ịchọpụta atụmatụ nke omume ya.

Fenofibrate nwere mmetụta na triglycerides, belata ego ha. Ọ na - enyere aka belata cholesterol n'ime ọbara. Nke a bụ n'ihi mmebi nke njikọ nke ọdụdụ asịd.

Ojiji nke ọgwụ nwere ike belata ọnụ ọgụgụ fibrinogen. Akụkụ ike na-esighi ike na-arụ ọrụ na glucose, na-enyere aka belata ọkwa ya. Njirimara ndị a na-eme ka Tricor dị irè maka ịgwọ ndị ọrịa atherosclerosis nwere ebumnuche ịmalite shuga.

Fenofibrate ruru ihe kachasị arụ ya mgbe elekere ise gasịchara (nke a na-emetụta njiri ahụ mmadụ niile).

Akụkụ dị ukwuu na ya na-ejikọ ya na albumin, protein protein, na-emepụta acid fenofibroic. A na-eme metabolism ya na imeju. Ihe ahụ nwere mmetụta na-adịgide adịgide - ọ dị ihe dị ka awa iri abụọ iji wepụ ọkara ya. Ọ na-ahapụ ahụ n'ahụ site na eriri afọ ya na akụrụ.

Ihe ngosi na contraindications

Nwere ike ịchọpụta ihe akụrụngwa a na-enyere aka site na ịmụ ntuziaka na ngosipụta maka ebumnuche ya.

A na-atụ aro ka iji ya maka mmebi iwu ndị dị ka:

Site n'ọrịa ndị dị otú ahụ, a na-eji Tricorr mee ihe ma ọ bụrụ na usoro ọgwụgwọ na-abụghị ọgwụ adịghị eweta nsonaazụ.

Ọzọkwa, dọkịta ahụ nwere ike ịkọ ọgwụ a iji merie ọrịa ndị ọzọ dịka akụkụ nke usoro ọgwụgwọ siri ike, ma ọ bụrụ na omume ndị dị otú ahụ kwesịrị ekwesị.

Ekwesịrị icheta na ọnụnọ nke ihe ndị na-egosi na ndenye ọgwụ apụtaghị iji mmanye eji ọgwụ a. Nchọpụta nke contraindications na-amanye gị ịhapụ iji ya.

Ndị a gụnyere:

nnukwu ọrịa imeju
nnukwu nsogbu akụrụ
anabataghị ihe mejupụtara ahụ,
lactation
ọrịa ọnya afọ
afọ ụmụaka.

Enwerekwa ikpe ebe enwere ike iji Tricor mee ihe, mana achọrọ oke ịkpachara anya:

a .ụrụma
hypothyroidism
nká
imebi imeju na akụrụ.

Nke a pụtara na ị ga - a takeụ ọgwụ a naanị dịka onye ọkachamara si gwara gị. Ngwọta onwe gi nwere ike iduga na nsogbu.

Ihe ngosi maka ojiji:

- hypercholesterolemia na hypertriglyceridemia dịpụrụ adịpụ ma ọ bụ agwakọta (ụdị dyslipidemia IIa, IIb, IV) na arụmọrụ nke usoro ọgwụgwọ na - abụghị ọgwụ (nri hypolipPs, oke ibu, mmega ahụ na - abawanye ụba), ọkachasị na ọnụnọ ihe ọghọm dyslipidemia dị ka ọbara ọgbụgbọ na anwụrụ ọkụ,
- Secondary hyperlipoproteinemia, n'ọnọdụ ebe hyperlipoproteinemia na-adịgide, n'agbanyeghị ọgwụgwọ dị mma nke ọrịa na-akpata (dịka ọmụmaatụ, dyslipidemia na ọrịa shuga mellitus).

Usoro onunu ogwu na uzo icho ogwu a.

Emere ndi okenye 1 tab. 1 oge / ụbọchị
Ndị ọrịa na-ewere okpu 1. fenofibrate 200 mg nwere ike ịga na taabụ 1. Tricorra 145 mg na-enweghị mgbakwunye dose ọzọ. Ndị ọrịa na-ewere otu taabụ. fenofibrate 160 mg / ụbọchị, nwere ike ịga were tab 1. Tricorra 145 mg na-enweghị mgbakwunye dose ọzọ.
A na-adụ ndị okenye ọrịa ndị okenye ka ha depụta usoro ọgwụgwọ maka ndị okenye.
Edebeghi iji ogwu a na ndi oria bu oria imeju.
A na-ewere ọgwụ Tricor 145 mg n'oge ọ bụla n'ụbọchị, n'agbanyeghị nri a ga-eri, a ga-elo mbadamba ihe niile, na-enweghị ịta ata, na iko mmiri.
Ekwesịrị ị Theụ ọgwụ ahụ ogologo oge, ka ọ na-aga n'ihu na-eso usoro nri onye ọrịa na-eso tupu ịmalite ọgwụgwọ Trikor.

Ntụziaka maka ojiji

A na-eji Tricor eme ihe naanị n'ime. Mgbe ị na-a theụ ọgwụ ahụ na usoro nke ọgwụ ọgwụ mg 145, ị nwere ike ị drinkụ ya n'agbanyeghị nri. Ọ bụrụ na etinyere ọgwụ ọgwụ ruru 160 mg, ekwesịrị ị withụ ọgwụ a. Ọ dịghị mkpa ịka nkata ma taa ata ahụ, ọ bụ ihe amamihe dị na ya iji mmiri zuru oke.

Usoro onunu ogwu na usoro nhazi ka ndi okacha mara ka emechara ya mgbe omumuchara ihe onyonyo a na oria ndi ozo. Ọ bụrụ n ’ọnọdụ chọrọ mgbazi ya anọghị, a na-atụ aro onye ọrịa ka ọ were 145 ma ọ bụ 160 mg (1 mbadamba) kwa ụbọchị.

A na-ekpebi oge ọ ga-eji usoro ọgwụgwọ ahụ n’otu n’otu. Ọtụtụ mgbe, ọ na-ewe ogologo oge. Na mgbakwunye na ya, a na-atụ aro nri. A na-ekpebi ịdị irè nke ọgwụgwọ site na nsonaazụ nke ule iji chọpụta ego cholesterol na triglycerides.

Ọ bụrụgodị na ọ bụ ọkachamara depụtara ọgwụ ahụ, onye ọrịa ahụ kwesịrị iji nlezianya nyochaa mgbanwe na ọnọdụ ya. Ọdịdị nke mmeghachi omume ojoo ma ọ bụ enweghị mmetụta pụtara na Tricor adịghị mma maka ọnọdụ a. O nwekwara ike igosipụta mkpa ọ dị maka mmezi usoro onunu ogwu ma ọ bụ ọnụnọ nke contraindications zoro ezo.

Vidiyo gbasara cholesterol na ọrụ ya n’arụ:

Ndị Ọrịa na Nduzi Pụrụ Iche

Onu ogugu ndi oria a ka akwadoro nlezianya puru iche mgbe eji Tricor bu ndi mmadu ndi a:

Womenmụ nwanyị n’oge ime. A na - agbanye ọgwụ ike nke ọgwụ ahụ, ya mere, amachibido iji ya n'oge a.
Ndị nne mụrụ nwa. Edebeghi ihe Fenofibrate na aru nke mmiri ara ara ya na nke nwa. N'akụkụ a, ndị dọkịta anaghị eji Trikor maka ndị ọrịa dị otú ahụ.
Childrenmụaka. N’agbata afọ 18, a naghị eji ọgwụ a eme ihe, n’ihi na a maghị etu ihe mejupụtara ya nwere ike isi metụta ahụ ụmụaka.
Ndị okenye. Maka ụdị ndị ọrịa a, a na-ele iji ọgwụ ahụ anya dị ka ihe na-anabata. Mana tupu nhọpụta ya, ndị ọrịa chọrọ nyocha iji zere nsogbu ndị nwere ike ibute ya. A na-akụkwa usoro onunu ogwu.

Ndị ọzọ (na enweghị ọgwụ mgbochi) nwere ike iji ọgwụ dịka dọkịta nyere ha iwu.

Ekwesịrị ịkpachara anya mgbe ị na-eji Traicor na ọnụnọ nke nsogbu ndị na-esonụ n'ime ahụ:

Ọrịa akụrụ. N'ime ọrịa dị njọ nke akụkụ a, a machibidoro iji ọgwụ a iwu. Obere uzọ ihe dị iche iche na-arụ n’ọrụ akụrụ chọrọ nleba anya mgbe niile n’usoro ọgwụgwọ ji ya.
Ọrịa imeju. Maka obere nsogbu imeju, dọkịta nwere ike ịkọ ọgwụ Tricor mgbe nyochachara. Nnukwu mmebi bụ ihe kpatara ịhapụ ọgwụ ahụ.

Fenofibrate nwere ike imetụta ọrụ nke imeju, yabụ ọbụlagodi na enweghị nsogbu na mpaghara a, ịkwesịrị ịlele ọnọdụ ya oge ụfọdụ. Ọzọkwa, n'okpuru mmetụta nke ọgwụ ahụ, usoro ịmịnye ọbara ọbara nwere ike ịgbanwe - ọ dịkwa mkpa ịchịkwa nke a.

Mmetụta akụkụ na ị andụbiga mmanya ókè

Mgbe ị na-eji Tricorr, enwere ike ịme mmetụta. Site n'ike dị ukwuu, ị ga-ajụ ị withụ ọgwụ a.

Isi mmetụta dị na ọgwụ ahụ gụnyere:

ọgbụgbọ
isi ọwụwa
akwara mgbu
ịmụba ọnụ ọgụgụ ọbara na-acha ọcha
ịba ụba gas,
afọ ọsịsa
mgbu afọ
myositis
urticaria
ọria aru
itching
akpụkpọ anụ ahụ,
gallstones
alopecia
mmebi nwoke na nwanyi.

Ọ bụrụ na ọ dị mkpa, dọkịta kwesịrị ịgwa ha. Enweghị ọgwụ mgbochi akọwapụtara, ya mere, a na-enye ndị ọrịa Symptomatic ọgwụgwọ.

Edebeghị ihe ndekọ overdose. A na-atụ aro na ọgwụgwọ symptomatic kwesịrị inye aka na nchọpụta ya.

Njikọ Ọgwụ na Analogs

Ọgwụ nkwanye ugwu gụnyere njikọta ọgwụ ziri ezi ejiri. Ọ bụrụ na otu usoro agbanwe agbanwe mmetụta nke onye ọzọ, nsonaazụ ya nwere ike ịbụ nke a na-atụghị anya ya. Ya mere, ịkwesịrị ịtụle otú Tricor nwere ike isi metụta ọgwụ ndị a na-eji ya na ya.

Ihe ị ga - eme bụ ijikọ ọgwụ a na:

anticoagulants (fenofibrate na-eme ka mmetụta ha dịkwuo elu, nke na-akpata ihe ize ndụ ọbara ọgbụgba),
Cyclosporine (akụrụ nwere ike ịrụ ọrụ),
akwara (enwere ihe ojoo ojoo na aru ojoo).

N’ihe metụtara ọgwụ ndị ọzọ, a naghị achọpụta mgbanwe dị iche iche. Ka o sina dị, onye ọrịa ahụ ga-agwa dọkịta banyere ọgwụ niile ọ na-eji ka ọkachamara ahụ nwee ike ịkọwa ọgwụgwọ zuru oke.

Ihe kpatara iji ngwaọrụ analog nwere ike ịdị iche. Ọtụtụ mgbe, ndị ọrịa na-achọ ọgwụ analogues dị ọnụ ala karịa, ebe ọ bụ na ị drugụ ọgwụ dị oke ọnụ na-aga n'ihu bụ ọrụ dị oke ọnụ.

Ndị ọzọ na-enwe nchegbu banyere mmetụta ndị na-eme ka o siere ha ike ịrụ ọrụ nke ọma. N'akụkụ a, ndị ọkachamara na-ahọrọkarị ọgwụ nwere mmetụta yiri ya.

Ndị a gụnyere:

Offọdụ n'ime ego edepụtara nwere ihe dị ka nke Traicor. Maka ndị ọzọ, mmetụta yiri ya bụ njirimara, n'agbanyeghị ọdịiche dị na ngwa.

Iji jiri mmemme ahụ, ị ga-agakwuru dọkịta gị. Medication -ụ ọgwụ onwe gị dị ize ndụ mgbe niile, yabụ ịkwesịrị ijide n'aka na ọgwụ ahọrọ bụ nke kwesịrị ekwesị maka otu onye ọrịa.

Echiche onye ọrịa

Nyocha banyere ọgwụ Tricor na-adịkarị mma - ọtụtụ na-achọpụta mmetụta bara uru ya n'ahụ yana iwetulata cholesterol ọbara.

Saw Tricor ọnwa isii gara aga dịka otu dọkịta siri depụta ya. N'ihi ya, ọ kwụsịrị mgbu mgbu n'ụkwụ ya na ikpere ya. Ọbara ọbara m belatakwara, ọrịa m na-agbadakwa agbada. Obi dị ya mma ruo mgbe ọ kwụsịrị ị .ụ ya. Aria nile weghachiri, yabụ ana m eche ịrịọ dọkịta maka nkuzi nke abụọ.

Ọgwụ nyeere m aka iwepụ nsogbu nke cholesterol dị elu. Mana n'ihi ya, etolitere m ọrịa ọla kọpa - o doro anya, ọ nwere ụdị mmetụta ọ bụla. Ọ dị mkpa ịjụ iji ya.

Anọwo m na-eji ngwaahịa ahụ ọnwa 3 ugbu a. Na mbu enweghi mmetụta dị mma, ọ bụ naanị adịghị ike na isi ọwụwa. Mgbe ahụ ihe niile laghachiri na nkịtị, ule ahụ kara. Ihe mgbu na ogwe aka ya kwụsịkwara, ihe mgbochi ndị ahụ na-apụ n'anya. M na-eteta n'abalị n'ihi ha, mana ugbu a, nke a anaghị eme. Ahụ adịkwuola m ike - dịka a ga-asị na m tụgharịrị.

Ọnụ ego ọgwụ a na-akwụ na-adabere na usoro nke ihe eji arụ ọrụ dị n'ime ya na ọnụọgụ mbadamba ihe dị na ngwugwu ahụ. Maka ngwugwu nwere mbadamba 30 (145 mg) ịkwesịrị inye site na 750 ruo 900 rubles. Na usoro onunu ogwu nke 160 mg na ngwugwu yiri ya, ọnụahịa maka Tricor ga - abụ 850 ruo 1100 rubles.